SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'GLA'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KYV_A_RBFA501_1
(6,7-DIMETHYL-8-RIBIT
YLLUMAZINE SYNTHASE)		 1pie GALACTOKINASE
(Lactococcus
lactis) 		5 / 12 GLY A 347
GLU A  42
LEU A 136
ILE A  37
LEU A  39
 PO4  A 401 ( 3.9A)
GLA  A 400 (-3.4A)
None
None
None
 1.20A 1kyvA-1pieA:
undetectable
1kyvE-1pieA:
undetectable		 1kyvA-1pieA:
17.53
1kyvE-1pieA:
17.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KYV_D_RBFD504_1
(6,7-DIMETHYL-8-RIBIT
YLLUMAZINE SYNTHASE)		 1pie GALACTOKINASE
(Lactococcus
lactis) 		5 / 12 LEU A  39
GLY A 347
GLU A  42
LEU A 136
ILE A  37
 None
PO4  A 401 ( 3.9A)
GLA  A 400 (-3.4A)
None
None
 1.18A 1kyvC-1pieA:
undetectable
1kyvD-1pieA:
undetectable		 1kyvC-1pieA:
17.53
1kyvD-1pieA:
17.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KYV_E_RBFE505_1
(6,7-DIMETHYL-8-RIBIT
YLLUMAZINE SYNTHASE)		 1pie GALACTOKINASE
(Lactococcus
lactis) 		5 / 12 LEU A  39
GLY A 347
GLU A  42
LEU A 136
ILE A  37
 None
PO4  A 401 ( 3.9A)
GLA  A 400 (-3.4A)
None
None
 1.18A 1kyvD-1pieA:
undetectable
1kyvE-1pieA:
undetectable		 1kyvD-1pieA:
17.53
1kyvE-1pieA:
17.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LQT_A_ACTA1869_0
(FPRA)		 3r4z GLYCOSYL HYDROLASE
FAMILY 32, N
TERMINAL
(Saccharophagus
degradans) 		4 / 4 ASP A 282
HIS A 264
ARG A 235
GLU A 224
 None
GLA  A 375 (-4.0A)
GLA  A 375 (-2.8A)
GLA  A 375 (-2.9A)
 1.30A 1lqtA-3r4zA:
undetectable		 1lqtA-3r4zA:
22.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OSV_B_CHCB201_2
(BILE ACID RECEPTOR)		 1wuu GALACTOKINASE
(Homo
sapiens) 		4 / 5 HIS A 311
ARG A 312
ILE A 285
HIS A  44
 None
None
None
GLA  A 393 (-3.6A)
 1.48A 1osvB-1wuuA:
0.0		 1osvB-1wuuA:
19.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q8J_B_C2FB802_0
(5-METHYLTETRAHYDROFO
LATE S-HOMOCYSTEINE
METHYLTRANSFERASE)		 2dej PROBABLE
GALACTOKINASE
(Pyrococcus
horikoshii) 		5 / 12 GLU A 109
GLY A 146
SER A  81
GLY A  73
ILE A  74
 None
GLA  A 401 (-3.4A)
None
None
None
 1.11A 1q8jB-2dejA:
undetectable		 1q8jB-2dejA:
23.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RTS_B_D16B409_1
(THYMIDYLATE SYNTHASE)		 1pie GALACTOKINASE
(Lactococcus
lactis) 		4 / 7 ILE A 196
ASP A 183
LEU A 182
PHE A 185
 None
PO4  A 401 ( 3.2A)
GLA  A 400 ( 4.3A)
None
 0.87A 1rtsB-1pieA:
undetectable		 1rtsB-1pieA:
22.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RTS_B_D16B409_1
(THYMIDYLATE SYNTHASE)		 2dej PROBABLE
GALACTOKINASE
(Pyrococcus
horikoshii) 		4 / 7 ILE A 162
ASP A 149
LEU A 148
PHE A 151
 None
GLA  A 401 (-3.1A)
GLA  A 401 ( 4.3A)
None
 0.87A 1rtsB-2dejA:
undetectable		 1rtsB-2dejA:
23.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BR4_E_SAME301_1
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 1s4e GALACTOKINASE
(Pyrococcus
furiosus) 		3 / 3 SER A   8
ASP A 151
CYH A 147
 None
GLA  A 500 (-3.0A)
GLA  A 500 (-4.5A)
 1.14A 2br4E-1s4eA:
undetectable		 2br4E-1s4eA:
19.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BR4_E_SAME301_1
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 2dej PROBABLE
GALACTOKINASE
(Pyrococcus
horikoshii) 		3 / 3 SER A   6
ASP A 149
CYH A 145
 None
GLA  A 401 (-3.1A)
GLA  A 401 (-4.6A)
 1.07A 2br4E-2dejA:
undetectable		 2br4E-2dejA:
19.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2C8A_A_NCAA1252_0
(MONO-ADP-RIBOSYLTRAN
SFERASE C3)		 2dej PROBABLE
GALACTOKINASE
(Pyrococcus
horikoshii) 		4 / 7 SER A 105
ARG A   9
GLN A 150
GLU A 109
 APW  A 402 (-2.2A)
GLA  A 401 (-4.1A)
None
None
 1.08A 2c8aA-2dejA:
undetectable		 2c8aA-2dejA:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2E1Q_D_SALD5006_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		 4aw7 GH86A
BETA-PORPHYRANASE
(Bacteroides
plebeius) 		4 / 5 ARG A  75
THR A 112
LEU A 150
ALA A 200
 GLA  A1608 ( 4.9A)
None
None
None
 1.48A 2e1qD-4aw7A:
undetectable		 2e1qD-4aw7A:
17.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIN_W_CHDW1060_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 1)		 4rk9 CARBOHYDRATE ABC
TRANSPORTER
SUBSTRATE-BINDING
PROTEIN MSME
(Bacillus
licheniformis) 		4 / 6 ILE A 338
ARG A 307
MET A  40
THR A  39
 None
GLA  A 503 (-2.8A)
None
GLA  A 502 ( 3.8A)
 0.91A 2einN-4rk9A:
undetectable
2einW-4rk9A:
undetectable		 2einN-4rk9A:
21.64
2einW-4rk9A:
7.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2TSR_B_D16B409_1
(THYMIDYLATE SYNTHASE)		 1pie GALACTOKINASE
(Lactococcus
lactis) 		4 / 8 ILE A 196
ASP A 183
LEU A 182
PHE A 185
 None
PO4  A 401 ( 3.2A)
GLA  A 400 ( 4.3A)
None
 0.92A 2tsrB-1pieA:
undetectable		 2tsrB-1pieA:
22.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2TSR_B_D16B409_1
(THYMIDYLATE SYNTHASE)		 1s4e GALACTOKINASE
(Pyrococcus
furiosus) 		4 / 8 ILE A 164
ASP A 151
LEU A 150
PHE A 153
 None
GLA  A 500 (-3.0A)
GLA  A 500 ( 4.4A)
None
 0.86A 2tsrB-1s4eA:
undetectable		 2tsrB-1s4eA:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2TSR_B_D16B409_1
(THYMIDYLATE SYNTHASE)		 2dej PROBABLE
GALACTOKINASE
(Pyrococcus
horikoshii) 		4 / 8 ILE A 162
ASP A 149
LEU A 148
PHE A 151
 None
GLA  A 401 (-3.1A)
GLA  A 401 ( 4.3A)
None
 0.93A 2tsrB-2dejA:
undetectable		 2tsrB-2dejA:
23.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2UXP_B_CLMB1211_0
(HTH-TYPE
TRANSCRIPTIONAL
REGULATOR TTGR)		 4aw7 GH86A
BETA-PORPHYRANASE
(Bacteroides
plebeius) 		5 / 11 HIS A  53
ALA A 344
SER A 343
GLY A 282
ILE A 283
 L6S  A1610 (-4.0A)
L6S  A1610 ( 4.5A)
None
None
GLA  A1608 ( 4.7A)
 1.30A 2uxpB-4aw7A:
undetectable		 2uxpB-4aw7A:
14.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VQY_A_PARA1201_2
(AAC(6')-IB)		 4rk9 CARBOHYDRATE ABC
TRANSPORTER
SUBSTRATE-BINDING
PROTEIN MSME
(Bacillus
licheniformis) 		3 / 3 TRP A 224
GLN A 409
TRP A 383
 None
None
GLA  A 503 ( 4.0A)
 1.25A 2vqyA-4rk9A:
undetectable		 2vqyA-4rk9A:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WQ5_A_MIYA1120_1
(PHOSPHOLIPASE A2,
ACIDIC)		 1pie GALACTOKINASE
(Lactococcus
lactis) 		4 / 7 LEU A 327
ALA A 348
GLY A 347
ARG A  36
 None
GLA  A 400 ( 3.6A)
PO4  A 401 ( 3.9A)
PO4  A 401 ( 3.5A)
 0.94A 2wq5A-1pieA:
undetectable		 2wq5A-1pieA:
16.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WQ5_A_MIYA1120_1
(PHOSPHOLIPASE A2,
ACIDIC)		 1s4e GALACTOKINASE
(Pyrococcus
furiosus) 		5 / 7 LEU A 285
ALA A 305
GLY A 304
ARG A  11
PHE A 288
 None
GLA  A 500 (-3.7A)
GLA  A 500 (-4.0A)
GLA  A 500 (-4.3A)
None
 1.36A 2wq5A-1s4eA:
undetectable		 2wq5A-1s4eA:
14.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WQ5_A_MIYA1120_1
(PHOSPHOLIPASE A2,
ACIDIC)		 2dej PROBABLE
GALACTOKINASE
(Pyrococcus
horikoshii) 		5 / 7 LEU A 283
ALA A 303
GLY A 302
ARG A   9
PHE A 286
 None
GLA  A 401 (-3.7A)
GLA  A 401 ( 4.1A)
GLA  A 401 (-4.1A)
None
 1.30A 2wq5A-2dejA:
undetectable		 2wq5A-2dejA:
17.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X45_A_HSMA1162_1
(ALLERGEN ARG R 1)		 3r4z GLYCOSYL HYDROLASE
FAMILY 32, N
TERMINAL
(Saccharophagus
degradans) 		4 / 4 GLU A 309
ASP A 282
HIS A 264
GLU A 265
 None
None
GLA  A 375 (-4.0A)
GLA  A 375 ( 4.4A)
 1.23A 2x45A-3r4zA:
0.0		 2x45A-3r4zA:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZUH_A_CAMA422_0
(CAMPHOR
5-MONOOXYGENASE)		 5d62 AGGLUTININ
(Marasmius
oreades) 		4 / 6 THR A 120
LEU A  73
VAL A  84
VAL A 125
 None
None
None
GLA  A 308 ( 3.7A)
 1.09A 2zuhA-5d62A:
undetectable		 2zuhA-5d62A:
18.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ABK_W_CHDW1059_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 1)		 4rk9 CARBOHYDRATE ABC
TRANSPORTER
SUBSTRATE-BINDING
PROTEIN MSME
(Bacillus
licheniformis) 		4 / 5 ILE A 338
ARG A 307
MET A  40
THR A  39
 None
GLA  A 503 (-2.8A)
None
GLA  A 502 ( 3.8A)
 0.82A 3abkN-4rk9A:
undetectable
3abkW-4rk9A:
undetectable		 3abkN-4rk9A:
21.64
3abkW-4rk9A:
7.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG1_W_CHDW1059_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 1)		 4rk9 CARBOHYDRATE ABC
TRANSPORTER
SUBSTRATE-BINDING
PROTEIN MSME
(Bacillus
licheniformis) 		4 / 6 ILE A 338
ARG A 307
MET A  40
THR A  39
 None
GLA  A 503 (-2.8A)
None
GLA  A 502 ( 3.8A)
 0.89A 3ag1N-4rk9A:
undetectable
3ag1W-4rk9A:
undetectable		 3ag1N-4rk9A:
21.64
3ag1W-4rk9A:
7.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG2_W_CHDW1059_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 1)		 4rk9 CARBOHYDRATE ABC
TRANSPORTER
SUBSTRATE-BINDING
PROTEIN MSME
(Bacillus
licheniformis) 		4 / 7 ILE A 338
ARG A 307
MET A  40
THR A  39
 None
GLA  A 503 (-2.8A)
None
GLA  A 502 ( 3.8A)
 0.83A 3ag2N-4rk9A:
undetectable
3ag2W-4rk9A:
undetectable		 3ag2N-4rk9A:
21.64
3ag2W-4rk9A:
7.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG4_W_CHDW1059_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 1)		 4rk9 CARBOHYDRATE ABC
TRANSPORTER
SUBSTRATE-BINDING
PROTEIN MSME
(Bacillus
licheniformis) 		4 / 7 ILE A 338
ARG A 307
MET A  40
THR A  39
 None
GLA  A 503 (-2.8A)
None
GLA  A 502 ( 3.8A)
 0.82A 3ag4N-4rk9A:
undetectable
3ag4W-4rk9A:
undetectable		 3ag4N-4rk9A:
21.64
3ag4W-4rk9A:
7.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AIA_B_SAMB206_0
(UPF0217 PROTEIN
MJ1640)		 2aj4 GALACTOKINASE
(Saccharomyces
cerevisiae) 		4 / 5 SER A 433
GLY A 467
GLU A 400
CYH A 443
 None
GLA  A 529 ( 4.2A)
None
None
 0.96A 3aiaA-2aj4A:
undetectable
3aiaB-2aj4A:
undetectable		 3aiaA-2aj4A:
17.34
3aiaB-2aj4A:
17.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3J6P_B_TA1B502_1
(TUBULIN BETA CHAIN)		 2dej PROBABLE
GALACTOKINASE
(Pyrococcus
horikoshii) 		5 / 12 GLU A 137
LEU A 300
SER A 105
GLY A 146
LEU A 148
 APW  A 402 ( 4.8A)
None
APW  A 402 (-2.2A)
GLA  A 401 (-3.4A)
GLA  A 401 ( 4.3A)
 1.21A 3j6pB-2dejA:
undetectable		 3j6pB-2dejA:
24.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K13_A_THHA642_0
(5-METHYLTETRAHYDROFO
LATE-HOMOCYSTEINE
METHYLTRANSFERASE)		 1pie GALACTOKINASE
(Lactococcus
lactis) 		5 / 12 ASN A  38
GLY A  41
ARG A 289
VAL A 164
GLY A 180
 None
None
None
None
GLA  A 400 (-3.9A)
 1.28A 3k13A-1pieA:
undetectable		 3k13A-1pieA:
23.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K13_C_THHC643_0
(5-METHYLTETRAHYDROFO
LATE-HOMOCYSTEINE
METHYLTRANSFERASE)		 1pie GALACTOKINASE
(Lactococcus
lactis) 		5 / 12 ASN A  38
GLY A  41
ARG A 289
VAL A 164
GLY A 180
 None
None
None
None
GLA  A 400 (-3.9A)
 1.28A 3k13C-1pieA:
undetectable		 3k13C-1pieA:
23.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3REQ_A_ADNA801_1
(METHYLMALONYL-COA
MUTASE)		 1s4e GALACTOKINASE
(Pyrococcus
furiosus) 		4 / 4 TYR A  21
TYR A 240
GLU A 244
GLY A  16
 GLA  A 500 ( 4.9A)
None
None
None
 1.39A 3reqA-1s4eA:
undetectable		 3reqA-1s4eA:
19.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3REQ_A_ADNA801_1
(METHYLMALONYL-COA
MUTASE)		 2dej PROBABLE
GALACTOKINASE
(Pyrococcus
horikoshii) 		4 / 4 TYR A  19
TYR A 238
GLU A 242
GLY A  14
 GLA  A 401 ( 4.9A)
None
None
None
 1.47A 3reqA-2dejA:
undetectable		 3reqA-2dejA:
18.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VYW_D_SAMD401_1
(MNMC2)		 4rk9 CARBOHYDRATE ABC
TRANSPORTER
SUBSTRATE-BINDING
PROTEIN MSME
(Bacillus
licheniformis) 		4 / 5 GLU A  75
ASP A  92
ASP A 198
GLU A 306
 GLA  A 503 ( 3.1A)
None
GLA  A 503 (-4.4A)
None
 1.33A 3vywD-4rk9A:
undetectable		 3vywD-4rk9A:
20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_B_W9TB502_1
(HEMOLYTIC LECTIN
CEL-III)		 1wuu GALACTOKINASE
(Homo
sapiens) 		4 / 6 GLU A  43
GLY A 346
LEU A 314
TYR A 318
 GLA  A 393 (-3.7A)
GLA  A 393 ( 3.4A)
None
None
 0.82A 3w9tB-1wuuA:
undetectable		 3w9tB-1wuuA:
18.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_E_W9TE502_1
(HEMOLYTIC LECTIN
CEL-III)		 1wuu GALACTOKINASE
(Homo
sapiens) 		4 / 6 GLU A  43
GLY A 346
LEU A 314
TYR A 318
 GLA  A 393 (-3.7A)
GLA  A 393 ( 3.4A)
None
None
 0.82A 3w9tE-1wuuA:
undetectable		 3w9tE-1wuuA:
18.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_F_W9TF503_1
(HEMOLYTIC LECTIN
CEL-III)		 1wuu GALACTOKINASE
(Homo
sapiens) 		4 / 6 GLU A  43
GLY A 346
LEU A 314
TYR A 318
 GLA  A 393 (-3.7A)
GLA  A 393 ( 3.4A)
None
None
 0.80A 3w9tF-1wuuA:
undetectable		 3w9tF-1wuuA:
18.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WG7_W_CHDW101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 4rk9 CARBOHYDRATE ABC
TRANSPORTER
SUBSTRATE-BINDING
PROTEIN MSME
(Bacillus
licheniformis) 		4 / 6 ILE A 338
ARG A 307
MET A  40
THR A  39
 None
GLA  A 503 (-2.8A)
None
GLA  A 502 ( 3.8A)
 0.84A 3wg7N-4rk9A:
undetectable
3wg7W-4rk9A:
undetectable		 3wg7N-4rk9A:
21.64
3wg7W-4rk9A:
7.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WIP_J_ACHJ301_0
(ACETYLCHOLINE-BINDIN
G PROTEIN)		 6eon BETA-GALACTOSIDASE
(Bacteroides
thetaiotaomicron) 		4 / 8 ARG A 275
LEU A 280
TYR A 323
TYR A 297
 None
None
None
GLA  A 801 (-4.5A)
 1.30A 3wipF-6eonA:
undetectable
3wipJ-6eonA:
undetectable		 3wipF-6eonA:
14.25
3wipJ-6eonA:
14.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZOD_A_HQEA1173_1
(FMN-BINDING PROTEIN)		 3r4z GLYCOSYL HYDROLASE
FAMILY 32, N
TERMINAL
(Saccharophagus
degradans) 		4 / 7 HIS A 264
ASP A  52
HIS A 206
HIS A 333
 GLA  A 375 (-4.0A)
None
None
None
 1.20A 3zodA-3r4zA:
undetectable		 3zodA-3r4zA:
19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZQ8_D_DVAD8_0
(VAL-GRAMICIDIN A)		 5fkc BETA-FRUCTOFURANOSID
ASE
(Xanthophyllomyce
s
dendrorhous) 		3 / 3 TRP A  77
VAL A 144
TRP A 105
 None
None
GLA  A3003 ( 3.7A)
 1.16A 3zq8C-5fkcA:
undetectable
3zq8D-5fkcA:
undetectable		 3zq8C-5fkcA:
16.92
3zq8D-5fkcA:
16.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FFW_B_715B801_2
(DIPEPTIDYL PEPTIDASE
4)		 4aw7 GH86A
BETA-PORPHYRANASE
(Bacteroides
plebeius) 		3 / 3 ARG A 217
TYR A 237
ASN A 253
 CL  A1615 ( 4.7A)
GLA  A1608 (-4.0A)
None
 0.70A 4ffwB-4aw7A:
2.0		 4ffwB-4aw7A:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FP9_F_SAMF401_1
(METHYLTRANSFERASE
NSUN4)		 4rk9 CARBOHYDRATE ABC
TRANSPORTER
SUBSTRATE-BINDING
PROTEIN MSME
(Bacillus
licheniformis) 		3 / 3 ASP A 374
ARG A 375
ASP A 384
 GLA  A 503 (-2.9A)
GLA  A 503 (-4.0A)
None
 0.88A 4fp9F-4rk9A:
undetectable		 4fp9F-4rk9A:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GKH_J_KANJ301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 1uas ALPHA-GALACTOSIDASE
(Oryza
sativa) 		4 / 6 ASP A 130
ASP A  51
ASP A 214
ASN A  14
 GLA  A1501 (-2.5A)
GLA  A1501 (-2.9A)
None
None
 1.34A 4gkhJ-1uasA:
2.1		 4gkhJ-1uasA:
22.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IQQ_A_D16A402_1
(THYMIDYLATE SYNTHASE)		 1s4e GALACTOKINASE
(Pyrococcus
furiosus) 		4 / 7 ILE A 164
ASP A 151
LEU A 150
PHE A 153
 None
GLA  A 500 (-3.0A)
GLA  A 500 ( 4.4A)
None
 0.89A 4iqqA-1s4eA:
undetectable		 4iqqA-1s4eA:
22.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KOS_A_4KOA201_1
(UNCHARACTERIZED
PROTEIN)		 4rk9 CARBOHYDRATE ABC
TRANSPORTER
SUBSTRATE-BINDING
PROTEIN MSME
(Bacillus
licheniformis) 		5 / 12 GLY A 143
ILE A 303
PHE A 196
TYR A 372
LEU A 200
 None
None
None
GLA  A 503 (-3.6A)
None
 1.23A 4kosA-4rk9A:
undetectable		 4kosA-4rk9A:
16.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M2X_A_TMQA202_2
(DIHYDROFOLATE
REDUCTASE)		 5d62 AGGLUTININ
(Marasmius
oreades) 		3 / 3 TRP A  44
GLN A  36
THR A  41
 None
GLA  A 303 ( 4.8A)
GLA  A 303 ( 4.8A)
 1.00A 4m2xA-5d62A:
undetectable		 4m2xA-5d62A:
19.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M48_A_21BA704_1
(TRANSPORTER)		 1s4e GALACTOKINASE
(Pyrococcus
furiosus) 		4 / 8 ASP A 151
SER A 105
GLY A 101
ALA A 196
 GLA  A 500 (-3.0A)
MG  A 600 (-4.0A)
ADP  A 400 (-3.2A)
None
 0.84A 4m48A-1s4eA:
undetectable		 4m48A-1s4eA:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MM5_A_SREA603_1
(TRANSPORTER)		 2aj4 GALACTOKINASE
(Saccharomyces
cerevisiae) 		5 / 9 ASP A 217
VAL A 232
ALA A 240
GLY A 214
PHE A 234
 GLA  A 529 (-2.9A)
None
None
GLA  A 529 (-3.9A)
None
 1.21A 4mm5A-2aj4A:
undetectable		 4mm5A-2aj4A:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MME_B_29QB603_1
(TRANSPORTER)		 2aj4 GALACTOKINASE
(Saccharomyces
cerevisiae) 		5 / 9 ASP A 217
VAL A 232
ALA A 240
GLY A 214
PHE A 234
 GLA  A 529 (-2.9A)
None
None
GLA  A 529 (-3.9A)
None
 1.11A 4mmeB-2aj4A:
undetectable		 4mmeB-2aj4A:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MMF_A_29QA603_1
(TRANSPORTER)		 2aj4 GALACTOKINASE
(Saccharomyces
cerevisiae) 		5 / 9 ASP A 217
VAL A 232
ALA A 240
GLY A 214
PHE A 234
 GLA  A 529 (-2.9A)
None
None
GLA  A 529 (-3.9A)
None
 1.19A 4mmfA-2aj4A:
3.2		 4mmfA-2aj4A:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MMF_B_29QB603_1
(TRANSPORTER)		 2aj4 GALACTOKINASE
(Saccharomyces
cerevisiae) 		5 / 9 ASP A 217
VAL A 232
ALA A 240
GLY A 214
PHE A 234
 GLA  A 529 (-2.9A)
None
None
GLA  A 529 (-3.9A)
None
 1.20A 4mmfB-2aj4A:
3.2		 4mmfB-2aj4A:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MUB_A_OAQA302_0
(SULFOTRANSFERASE)		 3h55 ALPHA-N-ACETYLGALACT
OSAMINIDASE
(Homo
sapiens) 		5 / 12 PRO A 279
MET A 253
LEU A 281
GLY A 157
ASP A 156
 None
None
None
None
GLA  A1000 (-3.4A)
 1.42A 4mubA-3h55A:
undetectable		 4mubA-3h55A:
18.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MX0_A_BCZA513_1
(NEURAMINIDASE)		 4rk9 CARBOHYDRATE ABC
TRANSPORTER
SUBSTRATE-BINDING
PROTEIN MSME
(Bacillus
licheniformis) 		3 / 3 ARG A 375
ASP A 374
ARG A 307
 GLA  A 503 (-4.0A)
GLA  A 503 (-2.9A)
GLA  A 503 (-2.8A)
 0.94A 4mx0A-4rk9A:
undetectable		 4mx0A-4rk9A:
22.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P7N_A_GCSA702_1
(POLY-BETA-1,6-N-ACET
YL-D-GLUCOSAMINE
N-DEACETYLASE)		 1uas ALPHA-GALACTOSIDASE
(Oryza
sativa) 		3 / 3 ASP A 130
TYR A  93
TRP A 164
 GLA  A1501 (-2.5A)
GLA  A1501 (-4.4A)
GLA  A1501 (-4.1A)
 1.02A 4p7nA-1uasA:
10.8		 4p7nA-1uasA:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PFJ_A_ADNA502_1
(ADENOSYLHOMOCYSTEINA
SE)		 1wuu GALACTOKINASE
(Homo
sapiens) 		5 / 12 HIS A  44
THR A  45
ASP A 186
GLY A  42
MET A 185
 GLA  A 393 (-3.6A)
None
GLA  A 393 (-3.2A)
None
None
 1.48A 4pfjA-1wuuA:
undetectable		 4pfjA-1wuuA:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QB9_B_PARB500_1
(ENHANCED
INTRACELLULAR
SURVIVAL PROTEIN)		 6eon BETA-GALACTOSIDASE
(Bacteroides
thetaiotaomicron) 		5 / 9 PHE A 722
SER A 720
THR A 235
TYR A 325
GLY A 263
 None
None
None
GLA  A 801 (-4.7A)
None
 1.38A 4qb9B-6eonA:
0.0		 4qb9B-6eonA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R82_A_ACTA207_0
(OXIDOREDUCTASE)		 4uoz BETA-GALACTOSIDASE
(Bifidobacterium
animalis) 		4 / 4 GLU A 164
GLY A 166
HIS A 168
ARG A 125
 GLA  A 701 (-3.1A)
None
None
GLA  A 701 (-2.7A)
 1.34A 4r82A-4uozA:
undetectable
4r82B-4uozA:
undetectable		 4r82A-4uozA:
14.88
4r82B-4uozA:
14.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RP8_C_ASCC501_1
(ASCORBATE-SPECIFIC
PERMEASE IIC
COMPONENT ULAA)		 1uas ALPHA-GALACTOSIDASE
(Oryza
sativa) 		3 / 3 SER A 160
TYR A 126
ASP A 216
 None
None
GLA  A1501 ( 4.4A)
 0.75A 4rp8C-1uasA:
undetectable		 4rp8C-1uasA:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RYA_A_MTLA501_1
(ABC TRANSPORTER
SUBSTRATE BINDING
PROTEIN (SORBITOL))		 6eon BETA-GALACTOSIDASE
(Bacteroides
thetaiotaomicron) 		3 / 3 GLU A 259
TYR A 323
GLU A 123
 GLA  A 801 (-2.7A)
None
GLA  A 801 (-2.8A)
 0.70A 4ryaA-6eonA:
undetectable		 4ryaA-6eonA:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TWD_H_377H401_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 1pie GALACTOKINASE
(Lactococcus
lactis) 		4 / 6 ASN A 172
GLU A 230
TYR A  46
PHE A 237
 None
None
GLA  A 400 (-4.5A)
None
 1.06A 4twdG-1pieA:
1.2
4twdH-1pieA:
0.0		 4twdG-1pieA:
23.00
4twdH-1pieA:
23.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X3U_B_SVRB101_2
(CHROMOBOX PROTEIN
HOMOLOG 7)		 1pie GALACTOKINASE
(Lactococcus
lactis) 		5 / 10 ARG A 281
LEU A 256
THR A 240
HIS A  43
LEU A 182
 None
None
None
GLA  A 400 (-3.6A)
GLA  A 400 ( 4.3A)
 1.28A 4x3uB-1pieA:
undetectable		 4x3uB-1pieA:
9.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZBQ_A_ACTA605_0
(SERUM ALBUMIN)		 6eon BETA-GALACTOSIDASE
(Bacteroides
thetaiotaomicron) 		4 / 6 TYR A  77
GLY A 117
GLU A 180
ASN A 181
 GLA  A 801 (-4.5A)
None
None
GLA  A 801 (-2.9A)
 1.21A 4zbqA-6eonA:
undetectable		 4zbqA-6eonA:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B1B_W_CHDW101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 4rk9 CARBOHYDRATE ABC
TRANSPORTER
SUBSTRATE-BINDING
PROTEIN MSME
(Bacillus
licheniformis) 		4 / 7 ILE A 338
ARG A 307
MET A  40
THR A  39
 None
GLA  A 503 (-2.8A)
None
GLA  A 502 ( 3.8A)
 0.85A 5b1bN-4rk9A:
undetectable
5b1bW-4rk9A:
undetectable		 5b1bN-4rk9A:
21.64
5b1bW-4rk9A:
7.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B3S_W_CHDW101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 4rk9 CARBOHYDRATE ABC
TRANSPORTER
SUBSTRATE-BINDING
PROTEIN MSME
(Bacillus
licheniformis) 		4 / 7 ILE A 338
ARG A 307
MET A  40
THR A  39
 None
GLA  A 503 (-2.8A)
None
GLA  A 502 ( 3.8A)
 0.87A 5b3sN-4rk9A:
undetectable
5b3sW-4rk9A:
undetectable		 5b3sN-4rk9A:
21.64
5b3sW-4rk9A:
7.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DV4_A_NMYA601_2
(CCR4-NOT
TRANSCRIPTION
COMPLEX SUBUNIT
6-LIKE)		 6eon BETA-GALACTOSIDASE
(Bacteroides
thetaiotaomicron) 		3 / 3 GLU A  48
TRP A 261
ASN A 181
 None
GLA  A 801 (-4.1A)
GLA  A 801 (-2.9A)
 1.03A 5dv4A-6eonA:
undetectable		 5dv4A-6eonA:
19.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GSM_A_GCSA801_1
(EXO-BETA-D-GLUCOSAMI
NIDASE)		 6eon BETA-GALACTOSIDASE
(Bacteroides
thetaiotaomicron) 		5 / 12 TYR A  77
CYH A 121
GLU A 123
GLU A 259
TYR A 297
 GLA  A 801 (-4.5A)
GLA  A 801 (-3.3A)
GLA  A 801 (-2.8A)
GLA  A 801 (-2.7A)
GLA  A 801 (-4.5A)
 0.37A 5gsmA-6eonA:
36.2		 5gsmA-6eonA:
24.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GSM_B_GCSB801_1
(EXO-BETA-D-GLUCOSAMI
NIDASE)		 6eon BETA-GALACTOSIDASE
(Bacteroides
thetaiotaomicron) 		5 / 12 TYR A  77
CYH A 121
GLU A 123
GLU A 259
TYR A 297
 GLA  A 801 (-4.5A)
GLA  A 801 (-3.3A)
GLA  A 801 (-2.8A)
GLA  A 801 (-2.7A)
GLA  A 801 (-4.5A)
 0.36A 5gsmB-6eonA:
36.7		 5gsmB-6eonA:
24.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IY5_W_CHDW101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 4rk9 CARBOHYDRATE ABC
TRANSPORTER
SUBSTRATE-BINDING
PROTEIN MSME
(Bacillus
licheniformis) 		4 / 7 ILE A 338
ARG A 307
MET A  40
THR A  39
 None
GLA  A 503 (-2.8A)
None
GLA  A 502 ( 3.8A)
 0.89A 5iy5N-4rk9A:
undetectable
5iy5W-4rk9A:
undetectable		 5iy5N-4rk9A:
21.64
5iy5W-4rk9A:
7.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LG3_F_Z80F401_1
(GAMMA-AMINOBUTYRIC-A
CID RECEPTOR SUBUNIT
BETA-1)		 1urx BETA-AGARASE A
(Zobellia
galactanivorans) 		5 / 10 ILE A 116
ILE A 249
VAL A 120
TRP A 138
ILE A 148
 None
None
None
GLA  A1292 ( 3.4A)
None
 1.30A 5lg3F-1urxA:
undetectable		 5lg3F-1urxA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M66_D_ADND502_1
(ADENOSYLHOMOCYSTEINA
SE)		 1wuu GALACTOKINASE
(Homo
sapiens) 		5 / 12 HIS A  44
THR A  45
ASP A 186
GLY A  42
MET A 185
 GLA  A 393 (-3.6A)
None
GLA  A 393 (-3.2A)
None
None
 1.48A 5m66D-1wuuA:
undetectable		 5m66D-1wuuA:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NZY_A_CE3A1103_1
(DNA CROSS-LINK
REPAIR 1A PROTEIN)		 1s4e GALACTOKINASE
(Pyrococcus
furiosus) 		4 / 8 TYR A  72
ASP A 151
VAL A 143
GLY A 144
 ADP  A 400 (-3.6A)
GLA  A 500 (-3.0A)
None
None
 1.00A 5nzyA-1s4eA:
undetectable		 5nzyA-1s4eA:
23.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NZY_A_CE3A1103_1
(DNA CROSS-LINK
REPAIR 1A PROTEIN)		 2dej PROBABLE
GALACTOKINASE
(Pyrococcus
horikoshii) 		4 / 8 TYR A  70
ASP A 149
VAL A 141
GLY A 142
 APW  A 402 (-3.8A)
GLA  A 401 (-3.1A)
None
None
 1.03A 5nzyA-2dejA:
undetectable		 5nzyA-2dejA:
24.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OGC_B_TA1B601_1
(TUBULIN BETA CHAIN)		 1s4e GALACTOKINASE
(Pyrococcus
furiosus) 		5 / 12 GLU A 139
LEU A 302
SER A 107
GLY A 148
LEU A 150
 MG  A 600 ( 4.9A)
None
MG  A 600 ( 2.1A)
GLA  A 500 (-3.6A)
GLA  A 500 ( 4.4A)
 1.28A 5ogcB-1s4eA:
undetectable		 5ogcB-1s4eA:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5U6N_A_SALA505_1
(UDP-GLYCOSYLTRANSFER
ASE 74F2)		 6eon BETA-GALACTOSIDASE
(Bacteroides
thetaiotaomicron) 		4 / 8 SER A 317
HIS A 267
PHE A 265
THR A 721
 None
None
GLA  A 801 (-4.7A)
CA  A 802 (-3.6A)
 1.31A 5u6nA-6eonA:
3.6		 5u6nA-6eonA:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5U6N_B_SALB504_1
(UDP-GLYCOSYLTRANSFER
ASE 74F2)		 6eon BETA-GALACTOSIDASE
(Bacteroides
thetaiotaomicron) 		4 / 6 SER A 317
HIS A 267
PHE A 265
THR A 721
 None
None
GLA  A 801 (-4.7A)
CA  A 802 (-3.6A)
 1.30A 5u6nB-6eonA:
2.1		 5u6nB-6eonA:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UL4_A_SAMA803_0
(OXSB PROTEIN)		 1s4e GALACTOKINASE
(Pyrococcus
furiosus) 		5 / 12 ALA A 297
GLY A 264
ILE A  15
GLU A  17
LEU A 274
 None
None
None
GLA  A 500 (-3.6A)
None
 1.11A 5ul4A-1s4eA:
undetectable		 5ul4A-1s4eA:
22.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UL4_A_SAMA803_0
(OXSB PROTEIN)		 2dej PROBABLE
GALACTOKINASE
(Pyrococcus
horikoshii) 		5 / 12 ALA A 295
GLY A 262
ILE A  13
GLU A  15
LEU A 272
 None
None
None
GLA  A 401 (-3.5A)
None
 1.12A 5ul4A-2dejA:
undetectable		 5ul4A-2dejA:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X24_A_LSNA502_1
(CYTOCHROME P450 2C9)		 2aj4 GALACTOKINASE
(Saccharomyces
cerevisiae) 		5 / 12 ALA A 229
LEU A  71
MET A 216
VAL A  68
GLY A  58
 None
None
GLA  A 529 ( 4.9A)
None
None
 1.21A 5x24A-2aj4A:
undetectable		 5x24A-2aj4A:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X7P_A_ACRA1431_1
(GLYCOSIDE HYDROLASE
FAMILY 31
ALPHA-GLUCOSIDASE)		 5d62 AGGLUTININ
(Marasmius
oreades) 		4 / 7 ASN A  95
HIS A  97
ASP A  28
GLY A  29
 GLA  A 305 (-3.3A)
GLA  A 305 (-3.9A)
GLA  A 306 ( 4.9A)
None
 0.85A 5x7pA-5d62A:
undetectable		 5x7pA-5d62A:
12.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y7P_G_CHDG401_0
(BILE SALT HYDROLASE)		 1pie GALACTOKINASE
(Lactococcus
lactis) 		5 / 10 LEU A 136
ILE A 355
PHE A  52
ALA A 186
LEU A 182
 None
None
None
None
GLA  A 400 ( 4.3A)
 1.27A 5y7pG-1pieA:
0.0		 5y7pG-1pieA:
22.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z86_W_CHDW101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 4rk9 CARBOHYDRATE ABC
TRANSPORTER
SUBSTRATE-BINDING
PROTEIN MSME
(Bacillus
licheniformis) 		4 / 6 ILE A 338
ARG A 307
MET A  40
THR A  39
 None
GLA  A 503 (-2.8A)
None
GLA  A 502 ( 3.8A)
 0.93A 5z86N-4rk9A:
undetectable
5z86W-4rk9A:
undetectable		 5z86N-4rk9A:
21.64
5z86W-4rk9A:
7.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZCO_W_CHDW101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 4rk9 CARBOHYDRATE ABC
TRANSPORTER
SUBSTRATE-BINDING
PROTEIN MSME
(Bacillus
licheniformis) 		4 / 6 ILE A 338
ARG A 307
MET A  40
THR A  39
 None
GLA  A 503 (-2.8A)
None
GLA  A 502 ( 3.8A)
 0.88A 5zcoN-4rk9A:
undetectable
5zcoW-4rk9A:
undetectable		 5zcoN-4rk9A:
21.64
5zcoW-4rk9A:
7.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FGD_A_D8ZA831_0
(GEPHYRIN)		 1urx BETA-AGARASE A
(Zobellia
galactanivorans) 		5 / 11 ASP A 252
PHE A 276
ILE A  95
TYR A 154
MET A 167
 GLA  A1292 ( 4.2A)
None
None
None
None
 1.35A 6fgdA-1urxA:
undetectable		 6fgdA-1urxA:
14.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6G1P_A_ACTA403_0
(ADP-RIBOSYLHYDROLASE
LIKE 2)		 1urx BETA-AGARASE A
(Zobellia
galactanivorans) 		3 / 3 TYR A 182
ASP A 181
GLN A 183
 None
GLA  A1292 ( 4.8A)
None
 0.89A 6g1pA-1urxA:
undetectable		 6g1pA-1urxA:
20.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNE_B_ACRB602_2
(-)		 2aj4 GALACTOKINASE
(Saccharomyces
cerevisiae) 		4 / 8 VAL A 281
TYR A 441
ASN A 275
TYR A 274
 None
None
None
GLA  A 529 (-4.8A)
 1.34A 6gneB-2aj4A:
undetectable		 6gneB-2aj4A:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6I5Z_D_SAMD401_0
(O-METHYLTRANSFERASE
1)		 1pie GALACTOKINASE
(Lactococcus
lactis) 		5 / 11 GLY A 347
GLY A 349
LEU A 316
VAL A 322
ASP A  45
 PO4  A 401 ( 3.9A)
None
None
None
GLA  A 400 (-2.8A)
 1.09A 6i5zD-1pieA:
undetectable		 6i5zD-1pieA:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6I5Z_D_SAMD401_0
(O-METHYLTRANSFERASE
1)		 1wuu GALACTOKINASE
(Homo
sapiens) 		5 / 11 GLY A 345
GLY A 347
LEU A 314
VAL A 320
ASP A  46
 ANP  A 395 (-3.5A)
None
None
None
GLA  A 393 (-3.0A)
 1.24A 6i5zD-1wuuA:
undetectable		 6i5zD-1wuuA:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6I5Z_D_SAMD401_0
(O-METHYLTRANSFERASE
1)		 2aj4 GALACTOKINASE
(Saccharomyces
cerevisiae) 		5 / 11 SER A 171
GLY A 469
GLY A 467
ASP A 449
LYS A 266
 ANP  A 532 (-3.1A)
None
GLA  A 529 ( 4.2A)
None
ANP  A 532 ( 3.1A)
 1.27A 6i5zD-2aj4A:
undetectable		 6i5zD-2aj4A:
22.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NMF_J_CHDJ101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 4rk9 CARBOHYDRATE ABC
TRANSPORTER
SUBSTRATE-BINDING
PROTEIN MSME
(Bacillus
licheniformis) 		4 / 7 ILE A 338
ARG A 307
MET A  40
THR A  39
 None
GLA  A 503 (-2.8A)
None
GLA  A 502 ( 3.8A)
 0.89A 6nmfA-4rk9A:
undetectable
6nmfJ-4rk9A:
undetectable		 6nmfA-4rk9A:
21.64
6nmfJ-4rk9A:
7.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NMP_J_CHDJ101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 4rk9 CARBOHYDRATE ABC
TRANSPORTER
SUBSTRATE-BINDING
PROTEIN MSME
(Bacillus
licheniformis) 		4 / 7 ILE A 338
ARG A 307
MET A  40
THR A  39
 None
GLA  A 503 (-2.8A)
None
GLA  A 502 ( 3.8A)
 0.96A 6nmpA-4rk9A:
undetectable
6nmpJ-4rk9A:
undetectable		 6nmpA-4rk9A:
21.64
6nmpJ-4rk9A:
7.35