SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'GL3'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1NW3_A_SAMA500_0 (HISTONE METHYLTRANSFERASE DOT1L)	3sqg	METHYL COENZYME M REDUCTASE, ALPHA SUBUNIT (uncultured archaeon)	5 / 12	ASP A 330 GLY A 502 ALA A 425 PHE A 334 ASN A 500	None None None 0AF A 333 (-3.5A) GL3 A 464 (-3.1A)	1.25A	1nw3A-3sqgA: undetectable	1nw3A-3sqgA: 21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1NW3_A_SAMA500_0 (HISTONE METHYLTRANSFERASE DOT1L)	3sqg	METHYL COENZYME M REDUCTASE, ALPHA SUBUNIT (uncultured archaeon)	5 / 12	GLY A 502 VAL A 492 ALA A 425 PHE A 334 ASN A 500	None 0AF A 333 ( 4.5A) None 0AF A 333 (-3.5A) GL3 A 464 (-3.1A)	1.21A	1nw3A-3sqgA: undetectable	1nw3A-3sqgA: 21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3TEG_A_DAHA416_1 (PHENYLALANYL-TRNA SYNTHETASE, MITOCHONDRIAL)	5a8r	METHYL-COENZYME M REDUCTASE II SUBUNIT ALPHA (Methanothermobac ter marburgensis)	5 / 12	GLN A 433 PHE A 445 GLY A 400 ALA A 404 GLY A 485	DYA A 452 ( 3.9A) GL3 A 447 (-3.9A) MGN A 402 ( 4.2A) None None	1.17A	3tegA-5a8rA: 3.9	3tegA-5a8rA: 20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3TEG_A_DAHA416_1 (PHENYLALANYL-TRNA SYNTHETASE, MITOCHONDRIAL)	5n28	METHYL-COENZYME M REDUCTASE SUBUNIT ALPHA (Methanotorris formicicus)	5 / 12	GLN A 433 PHE A 445 GLY A 400 ALA A 404 GLY A 485	TRX A 429 ( 4.3A) GL3 A 447 (-4.1A) MGN A 402 ( 4.4A) None TRX A 429 ( 4.5A)	1.14A	3tegA-5n28A: 4.0	3tegA-5n28A: 21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4WNU_C_QDNC602_1 (CYTOCHROME P450 2D6)	3sqg	METHYL COENZYME M REDUCTASE, ALPHA SUBUNIT METHYL-COENZYME M REDUCTASE, BETA SUBUNIT (uncultured archaeon)	5 / 11	LEU A 451 GLY B 350 LEU A 467 GLN A 470 ALA A 473	None None GL3 A 464 ( 4.6A) None None	1.31A	4wnuC-3sqgA: undetectable	4wnuC-3sqgA: 20.71

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["1NW3_A_SAMA500_0","HISTONE METHYLTRANSFERASE DOT1L","3sqg","METHYL COENZYME M REDUCTASE, ALPHA SUBUNIT","uncultured archaeon",5,"ASP A 330;GLY A 502;ALA A 425;PHE A 334;ASN A 500","None;None;None;0AF A 333 (-3.5A);GL3 A 464 (-3.1A)","1.25A","1nw3A-3sqgA:undetectable",null],["1NW3_A_SAMA500_0","HISTONE METHYLTRANSFERASE DOT1L","3sqg","METHYL COENZYME M REDUCTASE, ALPHA SUBUNIT","uncultured archaeon",5,"GLY A 502;VAL A 492;ALA A 425;PHE A 334;ASN A 500","None;0AF A 333 ( 4.5A);None;0AF A 333 (-3.5A);GL3 A 464 (-3.1A)","1.21A","1nw3A-3sqgA:undetectable","1nw3A-3sqgA:21.26"],["3TEG_A_DAHA416_1","PHENYLALANYL-TRNA SYNTHETASE, MITOCHONDRIAL","5a8r","METHYL-COENZYME M REDUCTASE II SUBUNIT ALPHA","Methanothermobacter marburgensis",5,"GLN A 433;PHE A 445;GLY A 400;ALA A 404;GLY A 485","DYA A 452 ( 3.9A);GL3 A 447 (-3.9A);MGN A 402 ( 4.2A);None;None","1.17A","3tegA-5a8rA:3.9","1nw3A-3sqgA:21.26"],["3TEG_A_DAHA416_1","PHENYLALANYL-TRNA SYNTHETASE, MITOCHONDRIAL","5n28","METHYL-COENZYME M REDUCTASE SUBUNIT ALPHA","Methanotorris formicicus",5,"GLN A 433;PHE A 445;GLY A 400;ALA A 404;GLY A 485","TRX A 429 ( 4.3A);GL3 A 447 (-4.1A);MGN A 402 ( 4.4A);None;TRX A 429 ( 4.5A)","1.14A","3tegA-5n28A:4.0","3tegA-5a8rA:20.18"],["4WNU_C_QDNC602_1","CYTOCHROME P450 2D6","3sqg","METHYL COENZYME M REDUCTASE, ALPHA SUBUNIT;METHYL-COENZYME M REDUCTASE, BETA SUBUNIT","uncultured archaeon",5,"LEU A 451;GLY B 350;LEU A 467;GLN A 470;ALA A 473","None;None;GL3 A 464 ( 4.6A);None;None","1.31A","4wnuC-3sqgA:undetectable","3tegA-5n28A:21.03"]]