SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'GKR'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DHI_A_MTXA161_1
(DIHYDROFOLATE
REDUCTASE)		 3p0w MANDELATE
RACEMASE/MUCONATE
LACTONIZING PROTEIN
(Ralstonia
pickettii) 		5 / 12 ILE A 239
ALA A 237
LEU A 250
LYS A 221
ILE A 204
 None
None
None
GKR  A 472 (-3.0A)
None
 1.02A 1dhiA-3p0wA:
undetectable		 1dhiA-3p0wA:
16.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DHI_B_MTXB361_1
(DIHYDROFOLATE
REDUCTASE)		 3p0w MANDELATE
RACEMASE/MUCONATE
LACTONIZING PROTEIN
(Ralstonia
pickettii) 		5 / 11 ILE A 239
ALA A 237
LEU A 250
LYS A 221
ILE A 204
 None
None
None
GKR  A 472 (-3.0A)
None
 1.02A 1dhiB-3p0wA:
undetectable		 1dhiB-3p0wA:
16.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DHJ_B_MTXB361_1
(DIHYDROFOLATE
REDUCTASE)		 3p0w MANDELATE
RACEMASE/MUCONATE
LACTONIZING PROTEIN
(Ralstonia
pickettii) 		5 / 12 ILE A 239
ALA A 237
LEU A 250
LYS A 221
ILE A 204
 None
None
None
GKR  A 472 (-3.0A)
None
 1.03A 1dhjB-3p0wA:
undetectable		 1dhjB-3p0wA:
15.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DRA_A_MTXA161_1
(DIHYDROFOLATE
REDUCTASE)		 3p0w MANDELATE
RACEMASE/MUCONATE
LACTONIZING PROTEIN
(Ralstonia
pickettii) 		5 / 12 ILE A 239
ALA A 237
LEU A 250
LYS A 221
ILE A 204
 None
None
None
GKR  A 472 (-3.0A)
None
 1.02A 1draA-3p0wA:
undetectable		 1draA-3p0wA:
16.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DRA_B_MTXB361_1
(DIHYDROFOLATE
REDUCTASE)		 3p0w MANDELATE
RACEMASE/MUCONATE
LACTONIZING PROTEIN
(Ralstonia
pickettii) 		5 / 12 ILE A 239
ALA A 237
LEU A 250
LYS A 221
ILE A 204
 None
None
None
GKR  A 472 (-3.0A)
None
 1.01A 1draB-3p0wA:
undetectable		 1draB-3p0wA:
16.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RB3_A_MTXA161_1
(DIHYDROFOLATE
REDUCTASE)		 3p0w MANDELATE
RACEMASE/MUCONATE
LACTONIZING PROTEIN
(Ralstonia
pickettii) 		5 / 10 ILE A 239
ALA A 237
LEU A 250
LYS A 221
ILE A 204
 None
None
None
GKR  A 472 (-3.0A)
None
 0.95A 1rb3A-3p0wA:
undetectable		 1rb3A-3p0wA:
16.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RD7_B_FOLB361_0
(DIHYDROFOLATE
REDUCTASE)		 3p0w MANDELATE
RACEMASE/MUCONATE
LACTONIZING PROTEIN
(Ralstonia
pickettii) 		5 / 12 ILE A 239
ALA A 237
LEU A 250
LYS A 221
ILE A 204
 None
None
None
GKR  A 472 (-3.0A)
None
 1.03A 1rd7B-3p0wA:
undetectable		 1rd7B-3p0wA:
16.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DRC_A_MTXA161_1
(DIHYDROFOLATE
REDUCTASE)		 3p0w MANDELATE
RACEMASE/MUCONATE
LACTONIZING PROTEIN
(Ralstonia
pickettii) 		5 / 12 ILE A 239
ALA A 237
LEU A 250
LYS A 221
ILE A 204
 None
None
None
GKR  A 472 (-3.0A)
None
 0.99A 2drcA-3p0wA:
undetectable		 2drcA-3p0wA:
16.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DRC_B_MTXB161_1
(DIHYDROFOLATE
REDUCTASE)		 3p0w MANDELATE
RACEMASE/MUCONATE
LACTONIZING PROTEIN
(Ralstonia
pickettii) 		5 / 12 ILE A 239
ALA A 237
LEU A 250
LYS A 221
ILE A 204
 None
None
None
GKR  A 472 (-3.0A)
None
 0.95A 2drcB-3p0wA:
undetectable		 2drcB-3p0wA:
16.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DRC_A_MTXA161_1
(DIHYDROFOLATE
REDUCTASE)		 3p0w MANDELATE
RACEMASE/MUCONATE
LACTONIZING PROTEIN
(Ralstonia
pickettii) 		5 / 12 ILE A 239
ALA A 237
LEU A 250
LYS A 221
ILE A 204
 None
None
None
GKR  A 472 (-3.0A)
None
 1.00A 3drcA-3p0wA:
undetectable		 3drcA-3p0wA:
16.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DRC_B_MTXB361_1
(DIHYDROFOLATE
REDUCTASE)		 3p0w MANDELATE
RACEMASE/MUCONATE
LACTONIZING PROTEIN
(Ralstonia
pickettii) 		5 / 12 ILE A 239
ALA A 237
LEU A 250
LYS A 221
ILE A 204
 None
None
None
GKR  A 472 (-3.0A)
None
 0.97A 3drcB-3p0wA:
undetectable		 3drcB-3p0wA:
16.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QL3_A_FOLA161_0
(DIHYDROFOLATE
REDUCTASE)		 3p0w MANDELATE
RACEMASE/MUCONATE
LACTONIZING PROTEIN
(Ralstonia
pickettii) 		5 / 12 ILE A 239
ALA A 237
LEU A 250
LYS A 221
ILE A 204
 None
None
None
GKR  A 472 (-3.0A)
None
 1.15A 3ql3A-3p0wA:
undetectable		 3ql3A-3p0wA:
16.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SG9_B_KANB305_1
(APH(2'')-ID)		 1jct GLUCARATE
DEHYDRATASE
(Escherichia
coli) 		4 / 8 ASN A 289
HIS A 368
ASP A 366
GLU A 216
 GKR  A 499 ( 2.9A)
GKR  A 499 (-4.1A)
None
None
 1.03A 3sg9B-1jctA:
0.0		 3sg9B-1jctA:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SG9_B_KANB305_1
(APH(2'')-ID)		 3pfr MANDELATE
RACEMASE/MUCONATE
LACTONIZING PROTEIN
(Actinobacillus
succinogenes) 		4 / 8 ASN A 290
HIS A 369
ASP A 367
GLU A 217
 MG  A 456 ( 2.6A)
GKR  A 457 (-3.8A)
None
None
 1.05A 3sg9B-3pfrA:
undetectable		 3sg9B-3pfrA:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TQ9_A_MTXA2001_1
(DIHYDROFOLATE
REDUCTASE)		 3p0w MANDELATE
RACEMASE/MUCONATE
LACTONIZING PROTEIN
(Ralstonia
pickettii) 		5 / 12 ILE A 239
ALA A 237
LEU A 250
LYS A 221
ILE A 204
 None
None
None
GKR  A 472 (-3.0A)
None
 1.04A 3tq9A-3p0wA:
undetectable		 3tq9A-3p0wA:
17.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P66_A_MTXA201_1
(DIHYDROFOLATE
REDUCTASE)		 3p0w MANDELATE
RACEMASE/MUCONATE
LACTONIZING PROTEIN
(Ralstonia
pickettii) 		5 / 11 ILE A 239
ALA A 237
LEU A 250
LYS A 221
ILE A 204
 None
None
None
GKR  A 472 (-3.0A)
None
 1.00A 4p66A-3p0wA:
undetectable		 4p66A-3p0wA:
16.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4USW_A_ACTA1470_0
(ADENYLATE CYCLASE
TYPE 10)		 1jct GLUCARATE
DEHYDRATASE
(Escherichia
coli) 		4 / 6 LEU A 206
LEU A 191
VAL A 188
PHE A 152
 None
None
None
GKR  A 499 (-4.7A)
 1.03A 4uswA-1jctA:
0.0		 4uswA-1jctA:
22.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4USW_A_ACTA1470_0
(ADENYLATE CYCLASE
TYPE 10)		 3pfr MANDELATE
RACEMASE/MUCONATE
LACTONIZING PROTEIN
(Actinobacillus
succinogenes) 		4 / 6 LEU A 207
LEU A 192
VAL A 189
PHE A 153
 None
None
None
GKR  A 457 (-4.7A)
 1.12A 4uswA-3pfrA:
undetectable		 4uswA-3pfrA:
22.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E8Q_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 3p0w MANDELATE
RACEMASE/MUCONATE
LACTONIZING PROTEIN
(Ralstonia
pickettii) 		5 / 12 ILE A 239
ALA A 237
LEU A 250
LYS A 221
ILE A 204
 None
None
None
GKR  A 472 (-3.0A)
None
 1.01A 5e8qA-3p0wA:
undetectable		 5e8qA-3p0wA:
16.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KB5_A_ADNA401_2
(ADENOSINE KINASE)		 1jct GLUCARATE
DEHYDRATASE
(Escherichia
coli) 		4 / 4 ASN A 289
LEU A 311
SER A 340
LEU A 148
 GKR  A 499 ( 2.9A)
None
None
None
 1.29A 5kb5A-1jctA:
1.0		 5kb5A-1jctA:
20.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L1F_A_6ZPA902_1
(GLUTAMATE RECEPTOR 2)		 1jct GLUCARATE
DEHYDRATASE
(Escherichia
coli) 		4 / 8 ASP A  22
TYR A 164
PHE A 152
SER A  29
 None
None
GKR  A 499 (-4.7A)
None
 1.12A 5l1fA-1jctA:
undetectable
5l1fB-1jctA:
undetectable		 5l1fA-1jctA:
20.20
5l1fB-1jctA:
20.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X7P_A_ACRA1431_1
(GLYCOSIDE HYDROLASE
FAMILY 31
ALPHA-GLUCOSIDASE)		 3p0w MANDELATE
RACEMASE/MUCONATE
LACTONIZING PROTEIN
(Ralstonia
pickettii) 		4 / 7 HIS A  32
ASP A 251
GLY A 224
ASN A  27
 GKR  A 472 (-3.9A)
MG  A 471 ( 2.6A)
None
GKR  A 472 (-3.5A)
 1.12A 5x7pA-3p0wA:
undetectable		 5x7pA-3p0wA:
17.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X7P_B_ACRB1431_1
(GLYCOSIDE HYDROLASE
FAMILY 31
ALPHA-GLUCOSIDASE)		 1jct GLUCARATE
DEHYDRATASE
(Escherichia
coli) 		4 / 5 HIS A  32
ASP A 235
GLY A 208
ASN A  27
 GKR  A 499 (-4.0A)
MG  A 498 ( 2.6A)
None
GKR  A 499 (-3.5A)
 1.15A 5x7pB-1jctA:
0.0		 5x7pB-1jctA:
15.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X7P_B_ACRB1431_1
(GLYCOSIDE HYDROLASE
FAMILY 31
ALPHA-GLUCOSIDASE)		 3p0w MANDELATE
RACEMASE/MUCONATE
LACTONIZING PROTEIN
(Ralstonia
pickettii) 		4 / 5 HIS A  32
ASP A 251
GLY A 224
ASN A  27
 GKR  A 472 (-3.9A)
MG  A 471 ( 2.6A)
None
GKR  A 472 (-3.5A)
 1.11A 5x7pB-3p0wA:
undetectable		 5x7pB-3p0wA:
17.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X7P_B_ACRB1431_1
(GLYCOSIDE HYDROLASE
FAMILY 31
ALPHA-GLUCOSIDASE)		 3pfr MANDELATE
RACEMASE/MUCONATE
LACTONIZING PROTEIN
(Actinobacillus
succinogenes) 		4 / 5 HIS A  33
ASP A 236
GLY A 209
ASN A  28
 GKR  A 457 (-3.8A)
MG  A 456 ( 2.7A)
None
GKR  A 457 (-3.4A)
 1.15A 5x7pB-3pfrA:
undetectable		 5x7pB-3pfrA:
16.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AZ3_1_PAR11802_1
(RRNA ALPHA
RIBOSOMAL PROTEIN
UL4
RIBOSOMAL PROTEIN
UL15
RIBOSOMAL PROTEIN
EL15)		 1jct GLUCARATE
DEHYDRATASE
(Escherichia
coli) 		3 / 3 ARG A  99
LYS A 207
ARG A 107
 None
GKR  A 499 (-3.1A)
None
 1.40A 6az3C-1jctA:
0.0
6az3L-1jctA:
0.0
6az3M-1jctA:
undetectable		 6az3C-1jctA:
9.86
6az3L-1jctA:
10.02
6az3M-1jctA:
10.54