SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'GK8'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MXD_A_ACRA734_1
(ALPHA AMYLASE)		 4gk8 HISTIDINOL-PHOSPHATA
SE
(Lactococcus
lactis) 		4 / 6 ASN A 195
HIS A 109
TYR A 157
GLY A 153
 None
ZN  A 301 ( 3.3A)
GK8  A 305 (-4.6A)
None
 1.11A 1mxdA-4gk8A:
2.9		 1mxdA-4gk8A:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MXG_A_ACRA444_1
(ALPHA AMYLASE)		 4gk8 HISTIDINOL-PHOSPHATA
SE
(Lactococcus
lactis) 		4 / 7 ASN A 195
HIS A 109
TYR A 157
GLY A 153
 None
ZN  A 301 ( 3.3A)
GK8  A 305 (-4.6A)
None
 1.15A 1mxgA-4gk8A:
5.3		 1mxgA-4gk8A:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1X70_B_715B801_2
(DIPEPTIDYL PEPTIDASE
IV)		 4gk8 HISTIDINOL-PHOSPHATA
SE
(Lactococcus
lactis) 		3 / 3 PHE A 152
TYR A 135
TYR A 157
 None
None
GK8  A 305 (-4.6A)
 1.06A 1x70B-4gk8A:
undetectable		 1x70B-4gk8A:
17.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VMY_A_GLYA502_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 4gk8 HISTIDINOL-PHOSPHATA
SE
(Lactococcus
lactis) 		4 / 7 HIS A   9
HIS A 230
ARG A 197
TYR A 157
 ZN  A 303 (-3.3A)
ZN  A 302 ( 3.3A)
GK8  A 305 (-3.3A)
GK8  A 305 (-4.6A)
 1.45A 2vmyA-4gk8A:
undetectable
2vmyB-4gk8A:
undetectable		 2vmyA-4gk8A:
20.53
2vmyB-4gk8A:
20.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JD1_A_FCNA202_1
(METALLOTHIOL
TRANSFERASE FOSB 2)		 4gk8 HISTIDINOL-PHOSPHATA
SE
(Lactococcus
lactis) 		5 / 12 HIS A  42
GLU A  81
ARG A 160
HIS A 109
TYR A 161
 ZN  A 302 ( 3.3A)
ZN  A 301 (-2.5A)
GK8  A 305 (-3.0A)
ZN  A 301 ( 3.3A)
None
 0.79A 4jd1A-4gk8A:
undetectable
4jd1B-4gk8A:
undetectable		 4jd1A-4gk8A:
21.99
4jd1B-4gk8A:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JD1_B_FCNB203_1
(METALLOTHIOL
TRANSFERASE FOSB 2)		 4gk8 HISTIDINOL-PHOSPHATA
SE
(Lactococcus
lactis) 		5 / 12 HIS A 109
TYR A 161
HIS A  42
GLU A  81
ARG A 160
 ZN  A 301 ( 3.3A)
None
ZN  A 302 ( 3.3A)
ZN  A 301 (-2.5A)
GK8  A 305 (-3.0A)
 0.94A 4jd1A-4gk8A:
undetectable
4jd1B-4gk8A:
undetectable		 4jd1A-4gk8A:
21.99
4jd1B-4gk8A:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JH3_A_FCNA204_1
(METALLOTHIOL
TRANSFERASE FOSB)		 4gk8 HISTIDINOL-PHOSPHATA
SE
(Lactococcus
lactis) 		5 / 12 HIS A  42
GLU A  81
ARG A 160
HIS A 109
TYR A 161
 ZN  A 302 ( 3.3A)
ZN  A 301 (-2.5A)
GK8  A 305 (-3.0A)
ZN  A 301 ( 3.3A)
None
 0.88A 4jh3A-4gk8A:
undetectable
4jh3B-4gk8A:
undetectable		 4jh3A-4gk8A:
19.01
4jh3B-4gk8A:
19.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P6X_I_HCYI900_2
(GLUCOCORTICOID
RECEPTOR)		 4gk8 HISTIDINOL-PHOSPHATA
SE
(Lactococcus
lactis) 		3 / 3 MET A  50
MET A  82
TYR A 117
 GK8  A 305 ( 3.9A)
None
GK8  A 305 ( 3.9A)
 1.44A 4p6xI-4gk8A:
undetectable		 4p6xI-4gk8A:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A06_A_SORA1341_0
(ALDOSE-ALDOSE
OXIDOREDUCTASE)		 4gk8 HISTIDINOL-PHOSPHATA
SE
(Lactococcus
lactis) 		4 / 7 ARG A 160
PHE A  52
ASP A  17
TYR A 157
 GK8  A 305 (-3.0A)
None
ZN  A 302 ( 2.2A)
GK8  A 305 (-4.6A)
 1.39A 5a06A-4gk8A:
2.0		 5a06A-4gk8A:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A06_C_SORC1341_0
(ALDOSE-ALDOSE
OXIDOREDUCTASE)		 4gk8 HISTIDINOL-PHOSPHATA
SE
(Lactococcus
lactis) 		4 / 7 ARG A 160
PHE A  52
ASP A  17
TYR A 157
 GK8  A 305 (-3.0A)
None
ZN  A 302 ( 2.2A)
GK8  A 305 (-4.6A)
 1.41A 5a06C-4gk8A:
2.0		 5a06C-4gk8A:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A06_D_SORD1342_0
(ALDOSE-ALDOSE
OXIDOREDUCTASE)		 4gk8 HISTIDINOL-PHOSPHATA
SE
(Lactococcus
lactis) 		4 / 7 ARG A 160
PHE A  52
ASP A  17
TYR A 157
 GK8  A 305 (-3.0A)
None
ZN  A 302 ( 2.2A)
GK8  A 305 (-4.6A)
 1.40A 5a06D-4gk8A:
undetectable		 5a06D-4gk8A:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A06_E_SORE1342_0
(ALDOSE-ALDOSE
OXIDOREDUCTASE)		 4gk8 HISTIDINOL-PHOSPHATA
SE
(Lactococcus
lactis) 		4 / 7 ARG A 160
PHE A  52
ASP A  17
TYR A 157
 GK8  A 305 (-3.0A)
None
ZN  A 302 ( 2.2A)
GK8  A 305 (-4.6A)
 1.40A 5a06E-4gk8A:
undetectable		 5a06E-4gk8A:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A06_F_SORF1343_0
(ALDOSE-ALDOSE
OXIDOREDUCTASE)		 4gk8 HISTIDINOL-PHOSPHATA
SE
(Lactococcus
lactis) 		4 / 7 ARG A 160
PHE A  52
ASP A  17
TYR A 157
 GK8  A 305 (-3.0A)
None
ZN  A 302 ( 2.2A)
GK8  A 305 (-4.6A)
 1.38A 5a06F-4gk8A:
undetectable		 5a06F-4gk8A:
21.08