SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'GIF'


List of Similar Pattern of Amino Acids


Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID
Hit
Macromolecule
Res.
Matches
Interface HETATM RMSD Dali
Z-score
Seq.
Identity (%)
View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RU9_H_ACTH611_0
(IMMUNOGLOBULIN
IGG2A, HEAVY CHAIN
IMMUNOGLOBULIN
IGG2A, LIGHT CHAIN)
5t9g GLYCOSIDE HYDROLASE
(Bacteroides
uniformis)
4 / 6 TRP A 657
ASN A 553
LEU A 554
PHE A 460
GIF  A 901 ( 4.4A)
None
None
None
1.06A 1ru9H-5t9gA:
5.8
1ru9L-5t9gA:
5.1
1ru9H-5t9gA:
12.13
1ru9L-5t9gA:
14.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RUK_L_ACTL611_0
(IMMUNOGLOBULIN
IGG2A, HEAVY CHAIN
IMMUNOGLOBULIN
IGG2A, LIGHT CHAIN)
5t9g GLYCOSIDE HYDROLASE
(Bacteroides
uniformis)
4 / 6 TRP A 657
ASN A 553
LEU A 554
PHE A 460
GIF  A 901 ( 4.4A)
None
None
None
1.08A 1rukH-5t9gA:
5.9
1rukL-5t9gA:
6.3
1rukH-5t9gA:
12.13
1rukL-5t9gA:
14.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F0Z_A_ZMRA381_1
(SIALIDASE 2)
5t9g GLYCOSIDE HYDROLASE
(Bacteroides
uniformis)
5 / 12 GLU A 583
ASN A 390
TYR A 459
GLU A 436
ARG A 352
GIF  A 901 (-2.9A)
GIF  A 901 (-3.7A)
None
GIF  A 901 (-2.9A)
None
1.39A 2f0zA-5t9gA:
undetectable
2f0zA-5t9gA:
17.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V3D_B_NBVB1504_1
(GLUCOSYLCERAMIDASE)
5t9g GLYCOSIDE HYDROLASE
(Bacteroides
uniformis)
5 / 11 ASN A 435
GLU A 436
TYR A 531
GLU A 552
TRP A 575
GIF  A 901 ( 4.0A)
GIF  A 901 (-2.9A)
None
GIF  A 901 (-2.8A)
GIF  A 901 (-4.0A)
0.69A 2v3dB-5t9gA:
14.4
2v3dB-5t9gA:
19.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OWX_B_XRAB233_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])
5t9g GLYCOSIDE HYDROLASE
(Bacteroides
uniformis)
5 / 11 PHE A 460
TRP A 657
GLY A 550
ASN A 508
ILE A 569
None
GIF  A 901 ( 4.4A)
None
None
None
1.28A 3owxA-5t9gA:
undetectable
3owxB-5t9gA:
undetectable
3owxA-5t9gA:
13.92
3owxB-5t9gA:
13.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R94_A_FLRA332_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C3)
5t9g GLYCOSIDE HYDROLASE
(Bacteroides
uniformis)
5 / 12 LEU A 554
SER A 530
TYR A 536
TRP A 461
PRO A 512
None
GIF  A 901 ( 4.7A)
None
None
None
1.48A 3r94A-5t9gA:
9.5
3r94A-5t9gA:
16.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZVM_B_DM2B303_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])
5t9g GLYCOSIDE HYDROLASE
(Bacteroides
uniformis)
5 / 11 PHE A 460
TRP A 657
GLY A 550
ASN A 508
ILE A 569
None
GIF  A 901 ( 4.4A)
None
None
None
1.33A 4zvmA-5t9gA:
undetectable
4zvmB-5t9gA:
undetectable
4zvmA-5t9gA:
13.92
4zvmB-5t9gA:
13.92