SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'GH3'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1SQF_A_SAMA430_1 (SUN PROTEIN)	4xj5	CYCLIC AMP-GMP SYNTHASE (Vibrio cholerae)	3 / 3	PRO A 261 ASP A 345 ASP A 266	GH3 A1013 ( 3.9A) GH3 A1014 ( 4.4A) None	0.77A	1sqfA-4xj5A: undetectable	1sqfA-4xj5A: 21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1SQF_A_SAMA430_1 (SUN PROTEIN)	4xj6	VC0179-LIKE PROTEIN (Escherichia coli)	3 / 3	PRO A 257 ASP A 341 ASP A 262	GH3 A 504 ( 4.1A) None None	0.52A	1sqfA-4xj6A: undetectable	1sqfA-4xj6A: 22.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4FEU_E_KANE301_1 (AMINOGLYCOSIDE 3'-PHOSPHOTRANSFERAS E APHA1-IAB)	4xj5	CYCLIC AMP-GMP SYNTHASE (Vibrio cholerae)	5 / 11	SER A 301 ASP A 291 ARG A 290 GLU A 28 GLU A 129	GH3 A1014 (-2.6A) None EDO A1004 ( 4.2A) None None	1.46A	4feuB-4xj5A: 0.0 4feuE-4xj5A: 0.0	4feuB-4xj5A: 22.22 4feuE-4xj5A: 22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5YBB_A_SAMA601_1 (TYPE I RESTRICTION-MODIFICA TION SYSTEM METHYLTRANSFERASE SUBUNIT)	4xj6	VC0179-LIKE PROTEIN (Escherichia coli)	4 / 5	PHE A 349 THR A 302 ASP A 344 ASN A 176	None None GH3 A 503 (-2.9A) GH3 A 504 ( 4.8A)	1.45A	5ybbA-4xj6A: undetectable	5ybbA-4xj6A: 22.60

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["1SQF_A_SAMA430_1","SUN PROTEIN","4xj5","CYCLIC AMP-GMP SYNTHASE","Vibrio cholerae",3,"PRO A 261;ASP A 345;ASP A 266","GH3 A1013 ( 3.9A);GH3 A1014 ( 4.4A);None","0.77A","1sqfA-4xj5A:undetectable",null],["1SQF_A_SAMA430_1","SUN PROTEIN","4xj6","VC0179-LIKE PROTEIN","Escherichia coli",3,"PRO A 257;ASP A 341;ASP A 262","GH3 A 504 ( 4.1A);None;None","0.52A","1sqfA-4xj6A:undetectable","1sqfA-4xj5A:21.22"],["4FEU_E_KANE301_1","AMINOGLYCOSIDE 3'-PHOSPHOTRANSFERASE APHA1-IAB;AMINOGLYCOSIDE 3'-PHOSPHOTRANSFERASE APHA1-IAB","4xj5","CYCLIC AMP-GMP SYNTHASE","Vibrio cholerae",5,"SER A 301;ASP A 291;ARG A 290;GLU A  28;GLU A 129","GH3 A1014 (-2.6A);None;EDO A1004 ( 4.2A);None;None","1.46A","4feuB-4xj5A:0.0;4feuE-4xj5A:0.0","1sqfA-4xj6A:22.86"],["5YBB_A_SAMA601_1","TYPE I RESTRICTION-MODIFICATION SYSTEM METHYLTRANSFERASE SUBUNIT","4xj6","VC0179-LIKE PROTEIN","Escherichia coli",4,"PHE A 349;THR A 302;ASP A 344;ASN A 176","None;None;GH3 A 503 (-2.9A);GH3 A 504 ( 4.8A)","1.45A","5ybbA-4xj6A:undetectable","4feuB-4xj5A:22.22;4feuE-4xj5A:22.22"]]