SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'GGL'


List of Similar Pattern of Amino Acids


Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID
Hit
Macromolecule
Res.
Matches
Interface HETATM RMSD Dali
Z-score
Seq.
Identity (%)
View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MXF_A_MTXA1278_1
(PTERIDINE REDUCTASE
2)
5eyf GLUTAMATE ABC
SUPERFAMILY ATP
BINDING CASSETTE
TRANSPORTER, BINDING
PROTEIN

(Enterococcus
faecium)
5 / 10 ARG A 118
TYR A 226
ASP A  68
TYR A 128
THR A 198
GGL  A 301 (-2.9A)
GGL  A 301 (-4.8A)
None
None
None
1.28A 1mxfA-5eyfA:
undetectable
1mxfA-5eyfA:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MXF_B_MTXB2278_1
(PTERIDINE REDUCTASE
2)
5eyf GLUTAMATE ABC
SUPERFAMILY ATP
BINDING CASSETTE
TRANSPORTER, BINDING
PROTEIN

(Enterococcus
faecium)
5 / 11 ARG A 118
TYR A 226
ASP A  68
TYR A 128
THR A 198
GGL  A 301 (-2.9A)
GGL  A 301 (-4.8A)
None
None
None
1.32A 1mxfB-5eyfA:
undetectable
1mxfB-5eyfA:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MXF_C_MTXC3278_1
(PTERIDINE REDUCTASE
2)
5eyf GLUTAMATE ABC
SUPERFAMILY ATP
BINDING CASSETTE
TRANSPORTER, BINDING
PROTEIN

(Enterococcus
faecium)
5 / 11 ARG A 118
TYR A 226
ASP A  68
TYR A 128
THR A 198
GGL  A 301 (-2.9A)
GGL  A 301 (-4.8A)
None
None
None
1.32A 1mxfC-5eyfA:
undetectable
1mxfC-5eyfA:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MXF_D_MTXD4278_1
(PTERIDINE REDUCTASE
2)
5eyf GLUTAMATE ABC
SUPERFAMILY ATP
BINDING CASSETTE
TRANSPORTER, BINDING
PROTEIN

(Enterococcus
faecium)
5 / 11 ARG A 118
TYR A 226
ASP A  68
TYR A 128
THR A 198
GGL  A 301 (-2.9A)
GGL  A 301 (-4.8A)
None
None
None
1.32A 1mxfD-5eyfA:
undetectable
1mxfD-5eyfA:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AOC_C_ERYC3402_1
(ACRIFLAVINE
RESISTANCE PROTEIN B)
6bsz METABOTROPIC
GLUTAMATE RECEPTOR 8

(Homo
sapiens)
3 / 3 THR A 179
SER A 310
LYS A 314
GGL  A 601 (-3.2A)
None
GGL  A 601 (-3.0A)
1.17A 3aocC-6bszA:
undetectable
3aocC-6bszA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EEY_C_SAMC300_0
(PUTATIVE RRNA
METHYLASE)
5eyf GLUTAMATE ABC
SUPERFAMILY ATP
BINDING CASSETTE
TRANSPORTER, BINDING
PROTEIN

(Enterococcus
faecium)
5 / 12 GLY A 206
GLY A 132
LEU A  53
THR A 111
THR A 113
None
None
None
GGL  A 301 (-3.9A)
GGL  A 301 (-4.0A)
1.03A 3eeyC-5eyfA:
undetectable
3eeyC-5eyfA:
24.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EEY_E_SAME300_0
(PUTATIVE RRNA
METHYLASE)
5eyf GLUTAMATE ABC
SUPERFAMILY ATP
BINDING CASSETTE
TRANSPORTER, BINDING
PROTEIN

(Enterococcus
faecium)
5 / 12 GLY A 206
GLY A 132
LEU A  53
THR A 111
THR A 113
None
None
None
GGL  A 301 (-3.9A)
GGL  A 301 (-4.0A)
1.07A 3eeyE-5eyfA:
undetectable
3eeyE-5eyfA:
24.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EEY_F_SAMF300_0
(PUTATIVE RRNA
METHYLASE)
5eyf GLUTAMATE ABC
SUPERFAMILY ATP
BINDING CASSETTE
TRANSPORTER, BINDING
PROTEIN

(Enterococcus
faecium)
5 / 12 GLY A 206
GLY A 132
LEU A  53
THR A 111
THR A 113
None
None
None
GGL  A 301 (-3.9A)
GGL  A 301 (-4.0A)
1.15A 3eeyF-5eyfA:
undetectable
3eeyF-5eyfA:
24.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JUS_B_ECNB602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)
5cni METABOTROPIC
GLUTAMATE RECEPTOR 2

(Homo
sapiens)
5 / 9 TYR A 458
THR A 316
TYR A 468
GLY A 296
ALA A 275
None
None
None
GGL  A 601 ( 4.3A)
None
1.13A 3jusB-5cniA:
undetectable
3jusB-5cniA:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JW3_A_TOPA208_1
(DIHYDROFOLATE
REDUCTASE)
5cni METABOTROPIC
GLUTAMATE RECEPTOR 2

(Homo
sapiens)
5 / 10 ALA A 293
LEU A 279
VAL A 303
TYR A 216
THR A 316
None
None
None
GGL  A 601 (-4.0A)
None
1.09A 3jw3A-5cniA:
3.7
3jw3A-5cniA:
14.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S3N_A_DLUA398_1
(PFV INTEGRASE)
5cni METABOTROPIC
GLUTAMATE RECEPTOR 2

(Homo
sapiens)
4 / 8 ASP A 188
ASP A 295
GLY A 296
ARG A  61
None
GGL  A 601 (-3.0A)
GGL  A 601 ( 4.3A)
GGL  A 601 (-2.9A)
0.98A 3s3nA-5cniA:
2.2
3s3nA-5cniA:
22.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PL1_A_SAMA401_0
(DUAL-SPECIFICITY RNA
METHYLTRANSFERASE
RLMN)
5cni METABOTROPIC
GLUTAMATE RECEPTOR 2

(Homo
sapiens)
5 / 11 PHE A 181
PRO A  39
SER A 167
ILE A 149
ASN A 153
None
CL  A 602 ( 4.0A)
GGL  A 601 (-4.5A)
None
None
1.37A 4pl1A-5cniA:
1.6
4pl1A-5cniA:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PL1_A_SAMA401_0
(DUAL-SPECIFICITY RNA
METHYLTRANSFERASE
RLMN)
6bsz METABOTROPIC
GLUTAMATE RECEPTOR 8

(Homo
sapiens)
5 / 11 PHE A 192
PRO A  53
SER A 178
ILE A 160
ASN A 164
None
None
GGL  A 601 (-4.6A)
None
None
1.34A 4pl1A-6bszA:
1.0
4pl1A-6bszA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UCK_B_SAMB2409_1
(RNA-DIRECTED RNA
POLYMERASE L)
5cni METABOTROPIC
GLUTAMATE RECEPTOR 2

(Homo
sapiens)
4 / 6 GLY A 217
GLU A 218
ASP A 274
ASP A 295
None
None
None
GGL  A 601 (-3.0A)
1.06A 4uckB-5cniA:
undetectable
4uckB-5cniA:
20.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UIL_H_QI9H1223_0
(FAB 314.1)
5cni METABOTROPIC
GLUTAMATE RECEPTOR 2

(Homo
sapiens)
5 / 12 ALA A 166
SER A 143
GLU A 318
GLY A 298
GLN A  60
GGL  A 601 (-3.8A)
CL  A 602 ( 4.1A)
GGL  A 601 ( 4.9A)
None
None
1.13A 4uilH-5cniA:
undetectable
4uilL-5cniA:
undetectable
4uilH-5cniA:
17.14
4uilL-5cniA:
17.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XP9_C_1WEC706_1
(TRANSPORTER)
5cni METABOTROPIC
GLUTAMATE RECEPTOR 2

(Homo
sapiens)
4 / 4 PHE A 269
ASP A 295
GLY A 220
SER A 294
None
GGL  A 601 (-3.0A)
None
None
1.42A 4xp9C-5cniA:
undetectable
4xp9C-5cniA:
23.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XP9_C_1WEC706_1
(TRANSPORTER)
6bsz METABOTROPIC
GLUTAMATE RECEPTOR 8

(Homo
sapiens)
4 / 4 PHE A 281
ASP A 309
GLY A 231
SER A 308
None
GGL  A 601 (-2.8A)
None
None
1.24A 4xp9C-6bszA:
undetectable
4xp9C-6bszA:
10.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HES_B_032B401_1
(MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE MLT)
6bsz METABOTROPIC
GLUTAMATE RECEPTOR 8

(Homo
sapiens)
6 / 12 GLY A  72
ALA A 177
TYR A 176
ALA A 153
ASP A 104
GLY A 228
None
GGL  A 601 (-3.5A)
None
None
None
None
1.18A 5hesB-6bszA:
undetectable
5hesB-6bszA:
15.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IWU_A_ERYA404_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)
5eyf GLUTAMATE ABC
SUPERFAMILY ATP
BINDING CASSETTE
TRANSPORTER, BINDING
PROTEIN

(Enterococcus
faecium)
4 / 6 GLY A  55
ILE A  97
ARG A  96
TYR A 128
None
None
GGL  A 301 (-3.1A)
None
1.07A 5iwuA-5eyfA:
undetectable
5iwuA-5eyfA:
20.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KVA_A_SAMA301_0
(CAFFEOYL-COA
O-METHYLTRANSFERASE)
5cni METABOTROPIC
GLUTAMATE RECEPTOR 2

(Homo
sapiens)
6 / 12 THR A 270
GLU A 218
GLY A 214
TYR A 216
ILE A 149
ASP A  95
None
None
None
GGL  A 601 (-4.0A)
None
None
1.41A 5kvaA-5cniA:
3.3
5kvaA-5cniA:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L4E_D_EDPD402_1
(PROTON-GATED ION
CHANNEL)
5eyf GLUTAMATE ABC
SUPERFAMILY ATP
BINDING CASSETTE
TRANSPORTER, BINDING
PROTEIN

(Enterococcus
faecium)
4 / 8 THR A 111
SER A  93
THR A 199
SER A 163
GGL  A 301 (-3.9A)
GGL  A 301 (-2.6A)
None
GGL  A 301 ( 4.1A)
0.76A 5l4eA-5eyfA:
undetectable
5l4eB-5eyfA:
undetectable
5l4eC-5eyfA:
undetectable
5l4eD-5eyfA:
undetectable
5l4eE-5eyfA:
undetectable
5l4eA-5eyfA:
24.59
5l4eB-5eyfA:
24.59
5l4eC-5eyfA:
24.59
5l4eD-5eyfA:
24.59
5l4eE-5eyfA:
24.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L4E_D_EDPD402_1
(PROTON-GATED ION
CHANNEL)
5eyf GLUTAMATE ABC
SUPERFAMILY ATP
BINDING CASSETTE
TRANSPORTER, BINDING
PROTEIN

(Enterococcus
faecium)
4 / 8 THR A 199
SER A 163
THR A 111
SER A  93
None
GGL  A 301 ( 4.1A)
GGL  A 301 (-3.9A)
GGL  A 301 (-2.6A)
0.75A 5l4eA-5eyfA:
undetectable
5l4eB-5eyfA:
undetectable
5l4eC-5eyfA:
undetectable
5l4eD-5eyfA:
undetectable
5l4eE-5eyfA:
undetectable
5l4eA-5eyfA:
24.59
5l4eB-5eyfA:
24.59
5l4eC-5eyfA:
24.59
5l4eD-5eyfA:
24.59
5l4eE-5eyfA:
24.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MRA_B_DM2B204_1
(SORCIN)
5cni METABOTROPIC
GLUTAMATE RECEPTOR 2

(Homo
sapiens)
4 / 6 TYR A 216
THR A 168
ASP A 215
GLY A 214
GGL  A 601 (-4.0A)
GGL  A 601 (-3.0A)
None
None
1.22A 5mraA-5cniA:
0.9
5mraB-5cniA:
0.8
5mraA-5cniA:
14.69
5mraB-5cniA:
14.69