SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'GGL'
DrReposER ID / Desc. | Hit PDBID |
Hit Macromolecule |
Res. Matches |
Interface | HETATM | RMSD | Dali Z-score |
Seq. Identity (%) |
View | Dock | |
---|---|---|---|---|---|---|---|---|---|---|---|
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1MXF_A_MTXA1278_1 (PTERIDINE REDUCTASE2) |
5eyf | GLUTAMATE ABCSUPERFAMILY ATPBINDING CASSETTETRANSPORTER, BINDINGPROTEIN (Enterococcusfaecium) | 5 / 10 | ARG A 118TYR A 226ASP A 68TYR A 128THR A 198 | GGL A 301 (-2.9A)GGL A 301 (-4.8A)NoneNoneNone | 1.28A | 1mxfA-5eyfA:undetectable | 1mxfA-5eyfA:21.58 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1MXF_B_MTXB2278_1 (PTERIDINE REDUCTASE2) |
5eyf | GLUTAMATE ABCSUPERFAMILY ATPBINDING CASSETTETRANSPORTER, BINDINGPROTEIN (Enterococcusfaecium) | 5 / 11 | ARG A 118TYR A 226ASP A 68TYR A 128THR A 198 | GGL A 301 (-2.9A)GGL A 301 (-4.8A)NoneNoneNone | 1.32A | 1mxfB-5eyfA:undetectable | 1mxfB-5eyfA:21.58 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1MXF_C_MTXC3278_1 (PTERIDINE REDUCTASE2) |
5eyf | GLUTAMATE ABCSUPERFAMILY ATPBINDING CASSETTETRANSPORTER, BINDINGPROTEIN (Enterococcusfaecium) | 5 / 11 | ARG A 118TYR A 226ASP A 68TYR A 128THR A 198 | GGL A 301 (-2.9A)GGL A 301 (-4.8A)NoneNoneNone | 1.32A | 1mxfC-5eyfA:undetectable | 1mxfC-5eyfA:21.58 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1MXF_D_MTXD4278_1 (PTERIDINE REDUCTASE2) |
5eyf | GLUTAMATE ABCSUPERFAMILY ATPBINDING CASSETTETRANSPORTER, BINDINGPROTEIN (Enterococcusfaecium) | 5 / 11 | ARG A 118TYR A 226ASP A 68TYR A 128THR A 198 | GGL A 301 (-2.9A)GGL A 301 (-4.8A)NoneNoneNone | 1.32A | 1mxfD-5eyfA:undetectable | 1mxfD-5eyfA:21.58 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3AOC_C_ERYC3402_1 (ACRIFLAVINERESISTANCE PROTEIN B) |
6bsz | METABOTROPICGLUTAMATE RECEPTOR 8 (Homosapiens) | 3 / 3 | THR A 179SER A 310LYS A 314 | GGL A 601 (-3.2A)NoneGGL A 601 (-3.0A) | 1.17A | 3aocC-6bszA:undetectable | 3aocC-6bszA:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3EEY_C_SAMC300_0 (PUTATIVE RRNAMETHYLASE) |
5eyf | GLUTAMATE ABCSUPERFAMILY ATPBINDING CASSETTETRANSPORTER, BINDINGPROTEIN (Enterococcusfaecium) | 5 / 12 | GLY A 206GLY A 132LEU A 53THR A 111THR A 113 | NoneNoneNoneGGL A 301 (-3.9A)GGL A 301 (-4.0A) | 1.03A | 3eeyC-5eyfA:undetectable | 3eeyC-5eyfA:24.25 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3EEY_E_SAME300_0 (PUTATIVE RRNAMETHYLASE) |
5eyf | GLUTAMATE ABCSUPERFAMILY ATPBINDING CASSETTETRANSPORTER, BINDINGPROTEIN (Enterococcusfaecium) | 5 / 12 | GLY A 206GLY A 132LEU A 53THR A 111THR A 113 | NoneNoneNoneGGL A 301 (-3.9A)GGL A 301 (-4.0A) | 1.07A | 3eeyE-5eyfA:undetectable | 3eeyE-5eyfA:24.25 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3EEY_F_SAMF300_0 (PUTATIVE RRNAMETHYLASE) |
5eyf | GLUTAMATE ABCSUPERFAMILY ATPBINDING CASSETTETRANSPORTER, BINDINGPROTEIN (Enterococcusfaecium) | 5 / 12 | GLY A 206GLY A 132LEU A 53THR A 111THR A 113 | NoneNoneNoneGGL A 301 (-3.9A)GGL A 301 (-4.0A) | 1.15A | 3eeyF-5eyfA:undetectable | 3eeyF-5eyfA:24.25 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3JUS_B_ECNB602_1 (LANOSTEROL 14-ALPHADEMETHYLASE) |
5cni | METABOTROPICGLUTAMATE RECEPTOR 2 (Homosapiens) | 5 / 9 | TYR A 458THR A 316TYR A 468GLY A 296ALA A 275 | NoneNoneNoneGGL A 601 ( 4.3A)None | 1.13A | 3jusB-5cniA:undetectable | 3jusB-5cniA:21.57 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3JW3_A_TOPA208_1 (DIHYDROFOLATEREDUCTASE) |
5cni | METABOTROPICGLUTAMATE RECEPTOR 2 (Homosapiens) | 5 / 10 | ALA A 293LEU A 279VAL A 303TYR A 216THR A 316 | NoneNoneNoneGGL A 601 (-4.0A)None | 1.09A | 3jw3A-5cniA:3.7 | 3jw3A-5cniA:14.09 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3S3N_A_DLUA398_1 (PFV INTEGRASE) |
5cni | METABOTROPICGLUTAMATE RECEPTOR 2 (Homosapiens) | 4 / 8 | ASP A 188ASP A 295GLY A 296ARG A 61 | NoneGGL A 601 (-3.0A)GGL A 601 ( 4.3A)GGL A 601 (-2.9A) | 0.98A | 3s3nA-5cniA:2.2 | 3s3nA-5cniA:22.13 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4PL1_A_SAMA401_0 (DUAL-SPECIFICITY RNAMETHYLTRANSFERASERLMN) |
5cni | METABOTROPICGLUTAMATE RECEPTOR 2 (Homosapiens) | 5 / 11 | PHE A 181PRO A 39SER A 167ILE A 149ASN A 153 | None CL A 602 ( 4.0A)GGL A 601 (-4.5A)NoneNone | 1.37A | 4pl1A-5cniA:1.6 | 4pl1A-5cniA:20.66 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4PL1_A_SAMA401_0 (DUAL-SPECIFICITY RNAMETHYLTRANSFERASERLMN) |
6bsz | METABOTROPICGLUTAMATE RECEPTOR 8 (Homosapiens) | 5 / 11 | PHE A 192PRO A 53SER A 178ILE A 160ASN A 164 | NoneNoneGGL A 601 (-4.6A)NoneNone | 1.34A | 4pl1A-6bszA:1.0 | 4pl1A-6bszA:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4UCK_B_SAMB2409_1 (RNA-DIRECTED RNAPOLYMERASE L) |
5cni | METABOTROPICGLUTAMATE RECEPTOR 2 (Homosapiens) | 4 / 6 | GLY A 217GLU A 218ASP A 274ASP A 295 | NoneNoneNoneGGL A 601 (-3.0A) | 1.06A | 4uckB-5cniA:undetectable | 4uckB-5cniA:20.04 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4UIL_H_QI9H1223_0 (FAB 314.1) |
5cni | METABOTROPICGLUTAMATE RECEPTOR 2 (Homosapiens) | 5 / 12 | ALA A 166SER A 143GLU A 318GLY A 298GLN A 60 | GGL A 601 (-3.8A) CL A 602 ( 4.1A)GGL A 601 ( 4.9A)NoneNone | 1.13A | 4uilH-5cniA:undetectable4uilL-5cniA:undetectable | 4uilH-5cniA:17.144uilL-5cniA:17.37 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4XP9_C_1WEC706_1 (TRANSPORTER) |
5cni | METABOTROPICGLUTAMATE RECEPTOR 2 (Homosapiens) | 4 / 4 | PHE A 269ASP A 295GLY A 220SER A 294 | NoneGGL A 601 (-3.0A)NoneNone | 1.42A | 4xp9C-5cniA:undetectable | 4xp9C-5cniA:23.16 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4XP9_C_1WEC706_1 (TRANSPORTER) |
6bsz | METABOTROPICGLUTAMATE RECEPTOR 8 (Homosapiens) | 4 / 4 | PHE A 281ASP A 309GLY A 231SER A 308 | NoneGGL A 601 (-2.8A)NoneNone | 1.24A | 4xp9C-6bszA:undetectable | 4xp9C-6bszA:10.69 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5HES_B_032B401_1 (MITOGEN-ACTIVATEDPROTEIN KINASEKINASE KINASE MLT) |
6bsz | METABOTROPICGLUTAMATE RECEPTOR 8 (Homosapiens) | 6 / 12 | GLY A 72ALA A 177TYR A 176ALA A 153ASP A 104GLY A 228 | NoneGGL A 601 (-3.5A)NoneNoneNoneNone | 1.18A | 5hesB-6bszA:undetectable | 5hesB-6bszA:15.03 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5IWU_A_ERYA404_1 (MACROLIDE2'-PHOSPHOTRANSFERASE II) |
5eyf | GLUTAMATE ABCSUPERFAMILY ATPBINDING CASSETTETRANSPORTER, BINDINGPROTEIN (Enterococcusfaecium) | 4 / 6 | GLY A 55ILE A 97ARG A 96TYR A 128 | NoneNoneGGL A 301 (-3.1A)None | 1.07A | 5iwuA-5eyfA:undetectable | 5iwuA-5eyfA:20.52 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5KVA_A_SAMA301_0 (CAFFEOYL-COAO-METHYLTRANSFERASE) |
5cni | METABOTROPICGLUTAMATE RECEPTOR 2 (Homosapiens) | 6 / 12 | THR A 270GLU A 218GLY A 214TYR A 216ILE A 149ASP A 95 | NoneNoneNoneGGL A 601 (-4.0A)NoneNone | 1.41A | 5kvaA-5cniA:3.3 | 5kvaA-5cniA:20.21 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5L4E_D_EDPD402_1 (PROTON-GATED IONCHANNEL) |
5eyf | GLUTAMATE ABCSUPERFAMILY ATPBINDING CASSETTETRANSPORTER, BINDINGPROTEIN (Enterococcusfaecium) | 4 / 8 | THR A 111SER A 93THR A 199SER A 163 | GGL A 301 (-3.9A)GGL A 301 (-2.6A)NoneGGL A 301 ( 4.1A) | 0.76A | 5l4eA-5eyfA:undetectable5l4eB-5eyfA:undetectable5l4eC-5eyfA:undetectable5l4eD-5eyfA:undetectable5l4eE-5eyfA:undetectable | 5l4eA-5eyfA:24.595l4eB-5eyfA:24.595l4eC-5eyfA:24.595l4eD-5eyfA:24.595l4eE-5eyfA:24.59 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5L4E_D_EDPD402_1 (PROTON-GATED IONCHANNEL) |
5eyf | GLUTAMATE ABCSUPERFAMILY ATPBINDING CASSETTETRANSPORTER, BINDINGPROTEIN (Enterococcusfaecium) | 4 / 8 | THR A 199SER A 163THR A 111SER A 93 | NoneGGL A 301 ( 4.1A)GGL A 301 (-3.9A)GGL A 301 (-2.6A) | 0.75A | 5l4eA-5eyfA:undetectable5l4eB-5eyfA:undetectable5l4eC-5eyfA:undetectable5l4eD-5eyfA:undetectable5l4eE-5eyfA:undetectable | 5l4eA-5eyfA:24.595l4eB-5eyfA:24.595l4eC-5eyfA:24.595l4eD-5eyfA:24.595l4eE-5eyfA:24.59 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5MRA_B_DM2B204_1 (SORCIN) |
5cni | METABOTROPICGLUTAMATE RECEPTOR 2 (Homosapiens) | 4 / 6 | TYR A 216THR A 168ASP A 215GLY A 214 | GGL A 601 (-4.0A)GGL A 601 (-3.0A)NoneNone | 1.22A | 5mraA-5cniA:0.95mraB-5cniA:0.8 | 5mraA-5cniA:14.695mraB-5cniA:14.69 |