SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'GER'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1RQJ_A_RISA901_1
(GERANYLTRANSTRANSFER
ASE)		 4fp4 POLYPRENYL
SYNTHETASE
(Pyrobaculum
calidifontis) 		5 / 11 ASP A  86
ASP A  90
ARG A  95
GLN A 147
THR A 163
 UNX  A 302 ( 2.6A)
UNX  A 302 ( 3.2A)
UNX  A 302 ( 4.6A)
GER  A 301 ( 4.7A)
None
 1.03A 1rqjA-4fp4A:
24.7		 1rqjA-4fp4A:
30.03
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1RQJ_A_RISA901_1
(GERANYLTRANSTRANSFER
ASE)		 4fp4 POLYPRENYL
SYNTHETASE
(Pyrobaculum
calidifontis) 		6 / 11 SER A  82
ASP A  86
ASP A  90
ARG A  95
THR A 163
GLN A 199
 GER  A 301 (-4.5A)
UNX  A 302 ( 2.6A)
UNX  A 302 ( 3.2A)
UNX  A 302 ( 4.6A)
None
None
 0.82A 1rqjA-4fp4A:
24.7		 1rqjA-4fp4A:
30.03
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1RQJ_A_RISA901_1
(GERANYLTRANSTRANSFER
ASE)		 4fp4 POLYPRENYL
SYNTHETASE
(Pyrobaculum
calidifontis) 		7 / 11 SER A  82
LEU A  83
ASP A  86
ASP A  90
ARG A  95
LYS A 162
THR A 163
 GER  A 301 (-4.5A)
UNL  A 303 ( 4.7A)
UNX  A 302 ( 2.6A)
UNX  A 302 ( 3.2A)
UNX  A 302 ( 4.6A)
GER  A 301 ( 4.8A)
None
 0.96A 1rqjA-4fp4A:
24.7		 1rqjA-4fp4A:
30.03
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1RQJ_B_RISB903_1
(GERANYLTRANSTRANSFER
ASE)		 4fp4 POLYPRENYL
SYNTHETASE
(Pyrobaculum
calidifontis) 		7 / 11 SER A  82
ASP A  86
ASP A  90
ARG A  95
LYS A 162
THR A 163
GLN A 199
 GER  A 301 (-4.5A)
UNX  A 302 ( 2.6A)
UNX  A 302 ( 3.2A)
UNX  A 302 ( 4.6A)
GER  A 301 ( 4.8A)
None
None
 1.07A 1rqjB-4fp4A:
24.8		 1rqjB-4fp4A:
30.03
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1RQJ_B_RISB903_1
(GERANYLTRANSTRANSFER
ASE)		 4fp4 POLYPRENYL
SYNTHETASE
(Pyrobaculum
calidifontis) 		7 / 11 SER A  82
LEU A  83
ASP A  86
ASP A  90
ARG A  95
LYS A 162
THR A 163
 GER  A 301 (-4.5A)
UNL  A 303 ( 4.7A)
UNX  A 302 ( 2.6A)
UNX  A 302 ( 3.2A)
UNX  A 302 ( 4.6A)
GER  A 301 ( 4.8A)
None
 0.96A 1rqjB-4fp4A:
24.8		 1rqjB-4fp4A:
30.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YHL_A_RISA1400_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4fp4 POLYPRENYL
SYNTHETASE
(Pyrobaculum
calidifontis) 		5 / 11 ASP A  86
ASP A  90
ARG A  95
GLN A 147
GLN A 199
 UNX  A 302 ( 2.6A)
UNX  A 302 ( 3.2A)
UNX  A 302 ( 4.6A)
GER  A 301 ( 4.7A)
None
 1.05A 1yhlA-4fp4A:
21.2		 1yhlA-4fp4A:
23.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YHL_A_RISA1400_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4fp4 POLYPRENYL
SYNTHETASE
(Pyrobaculum
calidifontis) 		6 / 11 LEU A  83
ASP A  86
ASP A  90
ARG A  95
LYS A 162
THR A 163
 UNL  A 303 ( 4.7A)
UNX  A 302 ( 2.6A)
UNX  A 302 ( 3.2A)
UNX  A 302 ( 4.6A)
GER  A 301 ( 4.8A)
None
 1.05A 1yhlA-4fp4A:
21.2		 1yhlA-4fp4A:
23.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YQ7_A_RISA901_1
(FARNESYL
PYROPHOSPHATE
SYNTHETASE)		 4fp4 POLYPRENYL
SYNTHETASE
(Pyrobaculum
calidifontis) 		6 / 11 ASP A  86
ASP A  90
ARG A  95
GLN A 147
THR A 163
GLN A 199
 UNX  A 302 ( 2.6A)
UNX  A 302 ( 3.2A)
UNX  A 302 ( 4.6A)
GER  A 301 ( 4.7A)
None
None
 1.07A 1yq7A-4fp4A:
20.4		 1yq7A-4fp4A:
24.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YQ7_A_RISA901_1
(FARNESYL
PYROPHOSPHATE
SYNTHETASE)		 4fp4 POLYPRENYL
SYNTHETASE
(Pyrobaculum
calidifontis) 		6 / 11 LEU A  83
ASP A  86
ASP A  90
ARG A  95
LYS A 162
THR A 163
 UNL  A 303 ( 4.7A)
UNX  A 302 ( 2.6A)
UNX  A 302 ( 3.2A)
UNX  A 302 ( 4.6A)
GER  A 301 ( 4.8A)
None
 1.05A 1yq7A-4fp4A:
20.4		 1yq7A-4fp4A:
24.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YV5_A_RISA901_1
(FARNESYL
PYROPHOSPHATE
SYNTHETASE)		 4fp4 POLYPRENYL
SYNTHETASE
(Pyrobaculum
calidifontis) 		5 / 10 ASP A  86
ASP A  90
ARG A  95
GLN A 147
THR A 163
 UNX  A 302 ( 2.6A)
UNX  A 302 ( 3.2A)
UNX  A 302 ( 4.6A)
GER  A 301 ( 4.7A)
None
 0.99A 1yv5A-4fp4A:
20.6		 1yv5A-4fp4A:
24.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YV5_A_RISA901_1
(FARNESYL
PYROPHOSPHATE
SYNTHETASE)		 4fp4 POLYPRENYL
SYNTHETASE
(Pyrobaculum
calidifontis) 		6 / 10 ASP A  86
ASP A  90
ARG A  95
LYS A 162
THR A 163
GLN A 199
 UNX  A 302 ( 2.6A)
UNX  A 302 ( 3.2A)
UNX  A 302 ( 4.6A)
GER  A 301 ( 4.8A)
None
None
 1.14A 1yv5A-4fp4A:
20.6		 1yv5A-4fp4A:
24.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YV5_A_RISA901_1
(FARNESYL
PYROPHOSPHATE
SYNTHETASE)		 4fp4 POLYPRENYL
SYNTHETASE
(Pyrobaculum
calidifontis) 		6 / 10 LEU A  83
ASP A  86
ASP A  90
ARG A  95
LYS A 162
THR A 163
 UNL  A 303 ( 4.7A)
UNX  A 302 ( 2.6A)
UNX  A 302 ( 3.2A)
UNX  A 302 ( 4.6A)
GER  A 301 ( 4.8A)
None
 1.03A 1yv5A-4fp4A:
20.6		 1yv5A-4fp4A:
24.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZW5_A_ZOLA901_1
(FARNESYL DIPHOSPHATE
SYNTHASE)		 4fp4 POLYPRENYL
SYNTHETASE
(Pyrobaculum
calidifontis) 		5 / 9 ASP A  86
ASP A  90
ARG A  95
GLN A 147
THR A 163
 UNX  A 302 ( 2.6A)
UNX  A 302 ( 3.2A)
UNX  A 302 ( 4.6A)
GER  A 301 ( 4.7A)
None
 1.01A 1zw5A-4fp4A:
20.3		 1zw5A-4fp4A:
24.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZW5_A_ZOLA901_1
(FARNESYL DIPHOSPHATE
SYNTHASE)		 4fp4 POLYPRENYL
SYNTHETASE
(Pyrobaculum
calidifontis) 		6 / 9 ASP A  86
ASP A  90
ARG A  95
LYS A 162
THR A 163
GLN A 199
 UNX  A 302 ( 2.6A)
UNX  A 302 ( 3.2A)
UNX  A 302 ( 4.6A)
GER  A 301 ( 4.8A)
None
None
 1.20A 1zw5A-4fp4A:
20.3		 1zw5A-4fp4A:
24.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BFP_C_H4BC1290_1
(PTERIDINE REDUCTASE
1)		 1vg0 RAB PROTEINS
GERANYLGERANYLTRANSF
ERASE COMPONENT A 1
(Rattus
norvegicus) 		4 / 8 LEU A 321
TYR A 320
LEU A 296
LEU A 359
 None
None
GER  A 952 ( 4.9A)
GER  A 952 ( 4.8A)
 0.94A 2bfpC-1vg0A:
4.0		 2bfpC-1vg0A:
17.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DM6_A_IMNA1401_1
(NADP-DEPENDENT
LEUKOTRIENE B4
12-HYDROXYDEHYDROGEN
ASE)		 1vg0 RAB PROTEINS
GERANYLGERANYLTRANSF
ERASE COMPONENT A 1
(Rattus
norvegicus) 		5 / 10 ILE A 338
ALA A 339
ILE A 471
PRO A 272
ILE A 260
 None
None
None
GER  A 952 (-4.2A)
None
 1.25A 2dm6A-1vg0A:
undetectable
2dm6B-1vg0A:
undetectable		 2dm6A-1vg0A:
19.40
2dm6B-1vg0A:
19.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2E91_A_ZOLA901_1
(GERANYLGERANYL
PYROPHOSPHATE
SYNTHETASE)		 4fp4 POLYPRENYL
SYNTHETASE
(Pyrobaculum
calidifontis) 		5 / 9 ASP A  86
ASP A  90
ARG A  95
GLN A 147
THR A 163
 UNX  A 302 ( 2.6A)
UNX  A 302 ( 3.2A)
UNX  A 302 ( 4.6A)
GER  A 301 ( 4.7A)
None
 0.97A 2e91A-4fp4A:
16.2		 2e91A-4fp4A:
28.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2E91_A_ZOLA901_1
(GERANYLGERANYL
PYROPHOSPHATE
SYNTHETASE)		 4fp4 POLYPRENYL
SYNTHETASE
(Pyrobaculum
calidifontis) 		5 / 9 ASP A  86
ASP A  90
ARG A  95
LYS A 162
THR A 163
 UNX  A 302 ( 2.6A)
UNX  A 302 ( 3.2A)
UNX  A 302 ( 4.6A)
GER  A 301 ( 4.8A)
None
 1.07A 2e91A-4fp4A:
16.2		 2e91A-4fp4A:
28.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2E91_B_ZOLB902_1
(GERANYLGERANYL
PYROPHOSPHATE
SYNTHETASE)		 4fp4 POLYPRENYL
SYNTHETASE
(Pyrobaculum
calidifontis) 		6 / 9 ASP A  86
ASP A  90
ARG A  95
GLN A 147
THR A 163
GLN A 199
 UNX  A 302 ( 2.6A)
UNX  A 302 ( 3.2A)
UNX  A 302 ( 4.6A)
GER  A 301 ( 4.7A)
None
None
 1.03A 2e91B-4fp4A:
15.3		 2e91B-4fp4A:
28.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2E91_B_ZOLB902_1
(GERANYLGERANYL
PYROPHOSPHATE
SYNTHETASE)		 4fp4 POLYPRENYL
SYNTHETASE
(Pyrobaculum
calidifontis) 		5 / 9 ASP A  86
ASP A  90
ARG A  95
LYS A 162
THR A 163
 UNX  A 302 ( 2.6A)
UNX  A 302 ( 3.2A)
UNX  A 302 ( 4.6A)
GER  A 301 ( 4.8A)
None
 1.13A 2e91B-4fp4A:
15.3		 2e91B-4fp4A:
28.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F89_F_210F9001_1
(FARNESYL DIPHOSPHATE
SYNTHASE)		 4fp4 POLYPRENYL
SYNTHETASE
(Pyrobaculum
calidifontis) 		6 / 9 ASP A  86
ASP A  90
ARG A  95
LYS A 162
THR A 163
GLN A 199
 UNX  A 302 ( 2.6A)
UNX  A 302 ( 3.2A)
UNX  A 302 ( 4.6A)
GER  A 301 ( 4.8A)
None
None
 1.14A 2f89F-4fp4A:
18.0		 2f89F-4fp4A:
24.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F8C_F_ZOLF9001_1
(FARNESYL DIPHOSPHATE
SYNTHASE)		 4fp4 POLYPRENYL
SYNTHETASE
(Pyrobaculum
calidifontis) 		6 / 11 ASP A  86
ASP A  90
ARG A  95
GLN A 147
THR A 163
GLN A 199
 UNX  A 302 ( 2.6A)
UNX  A 302 ( 3.2A)
UNX  A 302 ( 4.6A)
GER  A 301 ( 4.7A)
None
None
 1.06A 2f8cF-4fp4A:
21.0		 2f8cF-4fp4A:
24.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F8C_F_ZOLF9001_1
(FARNESYL DIPHOSPHATE
SYNTHASE)		 4fp4 POLYPRENYL
SYNTHETASE
(Pyrobaculum
calidifontis) 		6 / 11 ASP A  86
ASP A  90
ARG A  95
LYS A 162
THR A 163
GLN A 199
 UNX  A 302 ( 2.6A)
UNX  A 302 ( 3.2A)
UNX  A 302 ( 4.6A)
GER  A 301 ( 4.8A)
None
None
 1.16A 2f8cF-4fp4A:
21.0		 2f8cF-4fp4A:
24.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F8C_F_ZOLF9001_1
(FARNESYL DIPHOSPHATE
SYNTHASE)		 4fp4 POLYPRENYL
SYNTHETASE
(Pyrobaculum
calidifontis) 		6 / 11 LEU A  83
ASP A  86
ASP A  90
ARG A  95
LYS A 162
THR A 163
 UNL  A 303 ( 4.7A)
UNX  A 302 ( 2.6A)
UNX  A 302 ( 3.2A)
UNX  A 302 ( 4.6A)
GER  A 301 ( 4.8A)
None
 1.05A 2f8cF-4fp4A:
21.0		 2f8cF-4fp4A:
24.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F8Z_F_ZOLF5001_1
(FARNESYL DIPHOSPHATE
SYNTHASE)		 4fp4 POLYPRENYL
SYNTHETASE
(Pyrobaculum
calidifontis) 		6 / 10 ASP A  86
ASP A  90
ARG A  95
GLN A 147
THR A 163
GLN A 199
 UNX  A 302 ( 2.6A)
UNX  A 302 ( 3.2A)
UNX  A 302 ( 4.6A)
GER  A 301 ( 4.7A)
None
None
 1.09A 2f8zF-4fp4A:
20.9		 2f8zF-4fp4A:
24.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F8Z_F_ZOLF5001_1
(FARNESYL DIPHOSPHATE
SYNTHASE)		 4fp4 POLYPRENYL
SYNTHETASE
(Pyrobaculum
calidifontis) 		6 / 10 ASP A  86
ASP A  90
ARG A  95
LYS A 162
THR A 163
GLN A 199
 UNX  A 302 ( 2.6A)
UNX  A 302 ( 3.2A)
UNX  A 302 ( 4.6A)
GER  A 301 ( 4.8A)
None
None
 1.17A 2f8zF-4fp4A:
20.9		 2f8zF-4fp4A:
24.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F8Z_F_ZOLF5001_1
(FARNESYL DIPHOSPHATE
SYNTHASE)		 4fp4 POLYPRENYL
SYNTHETASE
(Pyrobaculum
calidifontis) 		6 / 10 LEU A  83
ASP A  86
ASP A  90
ARG A  95
LYS A 162
THR A 163
 UNL  A 303 ( 4.7A)
UNX  A 302 ( 2.6A)
UNX  A 302 ( 3.2A)
UNX  A 302 ( 4.6A)
GER  A 301 ( 4.8A)
None
 1.09A 2f8zF-4fp4A:
20.9		 2f8zF-4fp4A:
24.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F94_F_BFQF9001_1
(FARNESYL DIPHOSPHATE
SYNTHASE)		 4fp4 POLYPRENYL
SYNTHETASE
(Pyrobaculum
calidifontis) 		6 / 12 ASP A  86
ASP A  90
ARG A  95
GLN A 147
THR A 163
GLN A 199
 UNX  A 302 ( 2.6A)
UNX  A 302 ( 3.2A)
UNX  A 302 ( 4.6A)
GER  A 301 ( 4.7A)
None
None
 0.89A 2f94F-4fp4A:
20.8		 2f94F-4fp4A:
24.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F94_F_BFQF9001_1
(FARNESYL DIPHOSPHATE
SYNTHASE)		 4fp4 POLYPRENYL
SYNTHETASE
(Pyrobaculum
calidifontis) 		6 / 12 ASP A  86
ASP A  90
ARG A  95
LYS A 162
THR A 163
GLN A 199
 UNX  A 302 ( 2.6A)
UNX  A 302 ( 3.2A)
UNX  A 302 ( 4.6A)
GER  A 301 ( 4.8A)
None
None
 1.13A 2f94F-4fp4A:
20.8		 2f94F-4fp4A:
24.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F94_F_BFQF9001_1
(FARNESYL DIPHOSPHATE
SYNTHASE)		 4fp4 POLYPRENYL
SYNTHETASE
(Pyrobaculum
calidifontis) 		6 / 12 LEU A  83
ASP A  86
ASP A  90
ARG A  95
LYS A 162
THR A 163
 UNL  A 303 ( 4.7A)
UNX  A 302 ( 2.6A)
UNX  A 302 ( 3.2A)
UNX  A 302 ( 4.6A)
GER  A 301 ( 4.8A)
None
 1.00A 2f94F-4fp4A:
20.8		 2f94F-4fp4A:
24.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F9K_F_ZOLF9001_1
(FARNESYL DIPHOSPHATE
SYNTHASE)		 4fp4 POLYPRENYL
SYNTHETASE
(Pyrobaculum
calidifontis) 		6 / 10 ASP A  86
ASP A  90
ARG A  95
GLN A 147
THR A 163
GLN A 199
 UNX  A 302 ( 2.6A)
UNX  A 302 ( 3.2A)
UNX  A 302 ( 4.6A)
GER  A 301 ( 4.7A)
None
None
 1.04A 2f9kF-4fp4A:
20.6		 2f9kF-4fp4A:
24.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F9K_F_ZOLF9001_1
(FARNESYL DIPHOSPHATE
SYNTHASE)		 4fp4 POLYPRENYL
SYNTHETASE
(Pyrobaculum
calidifontis) 		6 / 10 ASP A  86
ASP A  90
ARG A  95
LYS A 162
THR A 163
GLN A 199
 UNX  A 302 ( 2.6A)
UNX  A 302 ( 3.2A)
UNX  A 302 ( 4.6A)
GER  A 301 ( 4.8A)
None
None
 1.15A 2f9kF-4fp4A:
20.6		 2f9kF-4fp4A:
24.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F9K_F_ZOLF9001_1
(FARNESYL DIPHOSPHATE
SYNTHASE)		 4fp4 POLYPRENYL
SYNTHETASE
(Pyrobaculum
calidifontis) 		6 / 10 LEU A  83
ASP A  86
ASP A  90
ARG A  95
LYS A 162
THR A 163
 UNL  A 303 ( 4.7A)
UNX  A 302 ( 2.6A)
UNX  A 302 ( 3.2A)
UNX  A 302 ( 4.6A)
GER  A 301 ( 4.8A)
None
 1.08A 2f9kF-4fp4A:
20.6		 2f9kF-4fp4A:
24.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2O1O_A_RISA400_1
(PUTATIVE FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4fp4 POLYPRENYL
SYNTHETASE
(Pyrobaculum
calidifontis) 		6 / 9 ASP A  86
ASP A  90
ARG A  95
GLN A 147
LYS A 162
THR A 163
 UNX  A 302 ( 2.6A)
UNX  A 302 ( 3.2A)
UNX  A 302 ( 4.6A)
GER  A 301 ( 4.7A)
GER  A 301 ( 4.8A)
None
 1.16A 2o1oA-4fp4A:
20.1		 2o1oA-4fp4A:
25.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2O1O_A_RISA400_1
(PUTATIVE FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4fp4 POLYPRENYL
SYNTHETASE
(Pyrobaculum
calidifontis) 		6 / 9 LEU A  83
ASP A  86
ASP A  90
ARG A  95
LYS A 162
THR A 163
 UNL  A 303 ( 4.7A)
UNX  A 302 ( 2.6A)
UNX  A 302 ( 3.2A)
UNX  A 302 ( 4.6A)
GER  A 301 ( 4.8A)
None
 1.00A 2o1oA-4fp4A:
20.1		 2o1oA-4fp4A:
25.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2O1O_B_RISB400_1
(PUTATIVE FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4fp4 POLYPRENYL
SYNTHETASE
(Pyrobaculum
calidifontis) 		5 / 10 ASP A  86
ASP A  90
LYS A 162
THR A 163
GLN A 199
 UNX  A 302 ( 2.6A)
UNX  A 302 ( 3.2A)
GER  A 301 ( 4.8A)
None
None
 1.23A 2o1oB-4fp4A:
18.0		 2o1oB-4fp4A:
25.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2O1O_B_RISB400_1
(PUTATIVE FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4fp4 POLYPRENYL
SYNTHETASE
(Pyrobaculum
calidifontis) 		6 / 10 LEU A  83
ASP A  86
ASP A  90
ARG A  95
LYS A 162
THR A 163
 UNL  A 303 ( 4.7A)
UNX  A 302 ( 2.6A)
UNX  A 302 ( 3.2A)
UNX  A 302 ( 4.6A)
GER  A 301 ( 4.8A)
None
 1.09A 2o1oB-4fp4A:
18.0		 2o1oB-4fp4A:
25.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q58_A_ZOLA1_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4fp4 POLYPRENYL
SYNTHETASE
(Pyrobaculum
calidifontis) 		5 / 10 ASP A  86
ASP A  90
ARG A  95
LYS A 162
THR A 163
 UNX  A 302 ( 2.6A)
UNX  A 302 ( 3.2A)
UNX  A 302 ( 4.6A)
GER  A 301 ( 4.8A)
None
 1.16A 2q58A-4fp4A:
20.0		 2q58A-4fp4A:
25.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q58_A_ZOLA1_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4fp4 POLYPRENYL
SYNTHETASE
(Pyrobaculum
calidifontis) 		5 / 10 ASP A  86
ASP A  90
LYS A 162
THR A 163
GLN A 199
 UNX  A 302 ( 2.6A)
UNX  A 302 ( 3.2A)
GER  A 301 ( 4.8A)
None
None
 1.31A 2q58A-4fp4A:
20.0		 2q58A-4fp4A:
25.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q58_B_ZOLB2_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4fp4 POLYPRENYL
SYNTHETASE
(Pyrobaculum
calidifontis) 		5 / 9 ASP A  86
ASP A  90
ARG A  95
LYS A 162
THR A 163
 UNX  A 302 ( 2.6A)
UNX  A 302 ( 3.2A)
UNX  A 302 ( 4.6A)
GER  A 301 ( 4.8A)
None
 1.06A 2q58B-4fp4A:
18.0		 2q58B-4fp4A:
25.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q58_B_ZOLB2_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4fp4 POLYPRENYL
SYNTHETASE
(Pyrobaculum
calidifontis) 		5 / 9 ASP A  86
ASP A  90
LYS A 162
THR A 163
GLN A 199
 UNX  A 302 ( 2.6A)
UNX  A 302 ( 3.2A)
GER  A 301 ( 4.8A)
None
None
 1.21A 2q58B-4fp4A:
18.0		 2q58B-4fp4A:
25.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QIS_A_RISA901_1
(FARNESYL
PYROPHOSPHATE
SYNTHETASE)		 4fp4 POLYPRENYL
SYNTHETASE
(Pyrobaculum
calidifontis) 		5 / 10 ASP A  86
ASP A  90
ARG A  95
GLN A 147
GLN A 199
 UNX  A 302 ( 2.6A)
UNX  A 302 ( 3.2A)
UNX  A 302 ( 4.6A)
GER  A 301 ( 4.7A)
None
 1.06A 2qisA-4fp4A:
20.9		 2qisA-4fp4A:
23.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QIS_A_RISA901_1
(FARNESYL
PYROPHOSPHATE
SYNTHETASE)		 4fp4 POLYPRENYL
SYNTHETASE
(Pyrobaculum
calidifontis) 		5 / 10 ASP A  86
ASP A  90
ARG A  95
LYS A 162
GLN A 199
 UNX  A 302 ( 2.6A)
UNX  A 302 ( 3.2A)
UNX  A 302 ( 4.6A)
GER  A 301 ( 4.8A)
None
 1.20A 2qisA-4fp4A:
20.9		 2qisA-4fp4A:
23.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QIS_A_RISA901_1
(FARNESYL
PYROPHOSPHATE
SYNTHETASE)		 4fp4 POLYPRENYL
SYNTHETASE
(Pyrobaculum
calidifontis) 		5 / 10 LEU A  83
ASP A  86
ASP A  90
ARG A  95
LYS A 162
 UNL  A 303 ( 4.7A)
UNX  A 302 ( 2.6A)
UNX  A 302 ( 3.2A)
UNX  A 302 ( 4.6A)
GER  A 301 ( 4.8A)
 1.13A 2qisA-4fp4A:
20.9		 2qisA-4fp4A:
23.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EZ3_A_ZOLA397_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE, PUTATIVE)		 4fp4 POLYPRENYL
SYNTHETASE
(Pyrobaculum
calidifontis) 		5 / 9 ASP A  86
ASP A  90
ARG A  95
LYS A 162
THR A 163
 UNX  A 302 ( 2.6A)
UNX  A 302 ( 3.2A)
UNX  A 302 ( 4.6A)
GER  A 301 ( 4.8A)
None
 1.08A 3ez3A-4fp4A:
20.1		 3ez3A-4fp4A:
23.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EZ3_B_ZOLB397_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE, PUTATIVE)		 4fp4 POLYPRENYL
SYNTHETASE
(Pyrobaculum
calidifontis) 		5 / 9 ASP A  86
ASP A  90
ARG A  95
LYS A 162
THR A 163
 UNX  A 302 ( 2.6A)
UNX  A 302 ( 3.2A)
UNX  A 302 ( 4.6A)
GER  A 301 ( 4.8A)
None
 1.02A 3ez3B-4fp4A:
19.7		 3ez3B-4fp4A:
23.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EZ3_C_ZOLC397_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE, PUTATIVE)		 4fp4 POLYPRENYL
SYNTHETASE
(Pyrobaculum
calidifontis) 		5 / 9 ASP A  86
ASP A  90
ARG A  95
GLN A 147
THR A 163
 UNX  A 302 ( 2.6A)
UNX  A 302 ( 3.2A)
UNX  A 302 ( 4.6A)
GER  A 301 ( 4.7A)
None
 1.08A 3ez3C-4fp4A:
20.1		 3ez3C-4fp4A:
23.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EZ3_C_ZOLC397_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE, PUTATIVE)		 4fp4 POLYPRENYL
SYNTHETASE
(Pyrobaculum
calidifontis) 		5 / 9 ASP A  86
ASP A  90
ARG A  95
LYS A 162
THR A 163
 UNX  A 302 ( 2.6A)
UNX  A 302 ( 3.2A)
UNX  A 302 ( 4.6A)
GER  A 301 ( 4.8A)
None
 1.10A 3ez3C-4fp4A:
20.1		 3ez3C-4fp4A:
23.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EZ3_D_ZOLD397_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE, PUTATIVE)		 4fp4 POLYPRENYL
SYNTHETASE
(Pyrobaculum
calidifontis) 		6 / 10 LEU A  83
ASP A  86
ASP A  90
ARG A  95
LYS A 162
THR A 163
 UNL  A 303 ( 4.7A)
UNX  A 302 ( 2.6A)
UNX  A 302 ( 3.2A)
UNX  A 302 ( 4.6A)
GER  A 301 ( 4.8A)
None
 1.03A 3ez3D-4fp4A:
19.5		 3ez3D-4fp4A:
23.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IBA_A_ZOLA901_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4fp4 POLYPRENYL
SYNTHETASE
(Pyrobaculum
calidifontis) 		6 / 10 ASP A  86
ASP A  90
ARG A  95
GLN A 147
THR A 163
GLN A 199
 UNX  A 302 ( 2.6A)
UNX  A 302 ( 3.2A)
UNX  A 302 ( 4.6A)
GER  A 301 ( 4.7A)
None
None
 1.22A 3ibaA-4fp4A:
20.9		 3ibaA-4fp4A:
23.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IBA_A_ZOLA901_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4fp4 POLYPRENYL
SYNTHETASE
(Pyrobaculum
calidifontis) 		6 / 10 ASP A  86
ASP A  90
ARG A  95
LYS A 162
THR A 163
GLN A 199
 UNX  A 302 ( 2.6A)
UNX  A 302 ( 3.2A)
UNX  A 302 ( 4.6A)
GER  A 301 ( 4.8A)
None
None
 1.17A 3ibaA-4fp4A:
20.9		 3ibaA-4fp4A:
23.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LDW_A_ZOLA397_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4fp4 POLYPRENYL
SYNTHETASE
(Pyrobaculum
calidifontis) 		5 / 9 ASP A  86
ASP A  90
ARG A  95
GLN A 147
THR A 163
 UNX  A 302 ( 2.6A)
UNX  A 302 ( 3.2A)
UNX  A 302 ( 4.6A)
GER  A 301 ( 4.7A)
None
 1.09A 3ldwA-4fp4A:
20.0		 3ldwA-4fp4A:
23.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LDW_A_ZOLA397_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4fp4 POLYPRENYL
SYNTHETASE
(Pyrobaculum
calidifontis) 		5 / 9 ASP A  86
ASP A  90
ARG A  95
LYS A 162
THR A 163
 UNX  A 302 ( 2.6A)
UNX  A 302 ( 3.2A)
UNX  A 302 ( 4.6A)
GER  A 301 ( 4.8A)
None
 1.06A 3ldwA-4fp4A:
20.0		 3ldwA-4fp4A:
23.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LDW_B_ZOLB397_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4fp4 POLYPRENYL
SYNTHETASE
(Pyrobaculum
calidifontis) 		5 / 9 ASP A  86
ASP A  90
ARG A  95
GLN A 147
THR A 163
 UNX  A 302 ( 2.6A)
UNX  A 302 ( 3.2A)
UNX  A 302 ( 4.6A)
GER  A 301 ( 4.7A)
None
 0.98A 3ldwB-4fp4A:
19.7		 3ldwB-4fp4A:
23.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LDW_B_ZOLB397_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4fp4 POLYPRENYL
SYNTHETASE
(Pyrobaculum
calidifontis) 		5 / 9 ASP A  86
ASP A  90
ARG A  95
LYS A 162
THR A 163
 UNX  A 302 ( 2.6A)
UNX  A 302 ( 3.2A)
UNX  A 302 ( 4.6A)
GER  A 301 ( 4.8A)
None
 1.04A 3ldwB-4fp4A:
19.7		 3ldwB-4fp4A:
23.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LDW_C_ZOLC397_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4fp4 POLYPRENYL
SYNTHETASE
(Pyrobaculum
calidifontis) 		5 / 9 ASP A  86
ASP A  90
ARG A  95
GLN A 147
THR A 163
 UNX  A 302 ( 2.6A)
UNX  A 302 ( 3.2A)
UNX  A 302 ( 4.6A)
GER  A 301 ( 4.7A)
None
 1.09A 3ldwC-4fp4A:
20.0		 3ldwC-4fp4A:
23.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LDW_C_ZOLC397_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4fp4 POLYPRENYL
SYNTHETASE
(Pyrobaculum
calidifontis) 		5 / 9 ASP A  86
ASP A  90
ARG A  95
LYS A 162
THR A 163
 UNX  A 302 ( 2.6A)
UNX  A 302 ( 3.2A)
UNX  A 302 ( 4.6A)
GER  A 301 ( 4.8A)
None
 1.10A 3ldwC-4fp4A:
20.0		 3ldwC-4fp4A:
23.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LDW_D_ZOLD397_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4fp4 POLYPRENYL
SYNTHETASE
(Pyrobaculum
calidifontis) 		5 / 9 ASP A  86
ASP A  90
ARG A  95
GLN A 147
THR A 163
 UNX  A 302 ( 2.6A)
UNX  A 302 ( 3.2A)
UNX  A 302 ( 4.6A)
GER  A 301 ( 4.7A)
None
 1.00A 3ldwD-4fp4A:
19.3		 3ldwD-4fp4A:
23.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LDW_D_ZOLD397_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4fp4 POLYPRENYL
SYNTHETASE
(Pyrobaculum
calidifontis) 		5 / 9 ASP A  86
ASP A  90
ARG A  95
LYS A 162
THR A 163
 UNX  A 302 ( 2.6A)
UNX  A 302 ( 3.2A)
UNX  A 302 ( 4.6A)
GER  A 301 ( 4.8A)
None
 1.05A 3ldwD-4fp4A:
19.3		 3ldwD-4fp4A:
23.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N45_F_ZOLF354_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4fp4 POLYPRENYL
SYNTHETASE
(Pyrobaculum
calidifontis) 		6 / 11 ASP A  86
ASP A  90
ARG A  95
GLN A 147
THR A 163
GLN A 199
 UNX  A 302 ( 2.6A)
UNX  A 302 ( 3.2A)
UNX  A 302 ( 4.6A)
GER  A 301 ( 4.7A)
None
None
 1.08A 3n45F-4fp4A:
21.0		 3n45F-4fp4A:
24.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N45_F_ZOLF354_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4fp4 POLYPRENYL
SYNTHETASE
(Pyrobaculum
calidifontis) 		6 / 11 ASP A  86
ASP A  90
ARG A  95
LYS A 162
THR A 163
GLN A 199
 UNX  A 302 ( 2.6A)
UNX  A 302 ( 3.2A)
UNX  A 302 ( 4.6A)
GER  A 301 ( 4.8A)
None
None
 1.16A 3n45F-4fp4A:
21.0		 3n45F-4fp4A:
24.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N45_F_ZOLF354_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4fp4 POLYPRENYL
SYNTHETASE
(Pyrobaculum
calidifontis) 		6 / 11 LEU A  83
ASP A  86
ASP A  90
ARG A  95
LYS A 162
THR A 163
 UNL  A 303 ( 4.7A)
UNX  A 302 ( 2.6A)
UNX  A 302 ( 3.2A)
UNX  A 302 ( 4.6A)
GER  A 301 ( 4.8A)
None
 1.07A 3n45F-4fp4A:
21.0		 3n45F-4fp4A:
24.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N46_F_ZOLF354_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4fp4 POLYPRENYL
SYNTHETASE
(Pyrobaculum
calidifontis) 		5 / 10 ASP A  86
ASP A  90
ARG A  95
GLN A 147
THR A 163
 UNX  A 302 ( 2.6A)
UNX  A 302 ( 3.2A)
UNX  A 302 ( 4.6A)
GER  A 301 ( 4.7A)
None
 0.96A 3n46F-4fp4A:
20.9		 3n46F-4fp4A:
24.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N46_F_ZOLF354_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4fp4 POLYPRENYL
SYNTHETASE
(Pyrobaculum
calidifontis) 		6 / 10 ASP A  86
ASP A  90
ARG A  95
LYS A 162
THR A 163
GLN A 199
 UNX  A 302 ( 2.6A)
UNX  A 302 ( 3.2A)
UNX  A 302 ( 4.6A)
GER  A 301 ( 4.8A)
None
None
 1.19A 3n46F-4fp4A:
20.9		 3n46F-4fp4A:
24.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N46_F_ZOLF354_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4fp4 POLYPRENYL
SYNTHETASE
(Pyrobaculum
calidifontis) 		6 / 10 LEU A  83
ASP A  86
ASP A  90
ARG A  95
LYS A 162
THR A 163
 UNL  A 303 ( 4.7A)
UNX  A 302 ( 2.6A)
UNX  A 302 ( 3.2A)
UNX  A 302 ( 4.6A)
GER  A 301 ( 4.8A)
None
 1.12A 3n46F-4fp4A:
20.9		 3n46F-4fp4A:
24.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ONN_A_ACTA270_0
(PROTEIN SSM1)		 4fp4 POLYPRENYL
SYNTHETASE
(Pyrobaculum
calidifontis) 		4 / 5 LEU A 143
SER A  82
LEU A 166
PRO A 165
 GER  A 301 ( 4.0A)
GER  A 301 (-4.5A)
None
None
 1.36A 3onnA-4fp4A:
undetectable		 3onnA-4fp4A:
25.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UJ6_A_SAMA300_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE)		 1hh4 RHO GDP-DISSOCIATION
INHIBITOR 1
(Homo
sapiens) 		5 / 12 TYR D 428
ILE D 412
GLY D 374
ILE D 414
LEU D 394
 None
GER  D1502 ( 4.3A)
None
None
None
 1.02A 3uj6A-1hh4D:
undetectable		 3uj6A-1hh4D:
22.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KFA_A_ZOLA404_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4fp4 POLYPRENYL
SYNTHETASE
(Pyrobaculum
calidifontis) 		5 / 9 LEU A  83
ASP A  86
ASP A  90
ARG A  95
LYS A 162
 UNL  A 303 ( 4.7A)
UNX  A 302 ( 2.6A)
UNX  A 302 ( 3.2A)
UNX  A 302 ( 4.6A)
GER  A 301 ( 4.8A)
 1.09A 4kfaA-4fp4A:
20.5		 4kfaA-4fp4A:
23.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KPD_A_RISA405_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4fp4 POLYPRENYL
SYNTHETASE
(Pyrobaculum
calidifontis) 		6 / 10 ASP A  86
ASP A  90
ARG A  95
GLN A 147
THR A 163
GLN A 199
 UNX  A 302 ( 2.6A)
UNX  A 302 ( 3.2A)
UNX  A 302 ( 4.6A)
GER  A 301 ( 4.7A)
None
None
 1.07A 4kpdA-4fp4A:
20.8		 4kpdA-4fp4A:
23.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KPD_A_RISA405_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4fp4 POLYPRENYL
SYNTHETASE
(Pyrobaculum
calidifontis) 		6 / 10 ASP A  86
ASP A  90
ARG A  95
LYS A 162
THR A 163
GLN A 199
 UNX  A 302 ( 2.6A)
UNX  A 302 ( 3.2A)
UNX  A 302 ( 4.6A)
GER  A 301 ( 4.8A)
None
None
 1.12A 4kpdA-4fp4A:
20.8		 4kpdA-4fp4A:
23.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KPD_A_RISA405_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4fp4 POLYPRENYL
SYNTHETASE
(Pyrobaculum
calidifontis) 		6 / 10 LEU A  83
ASP A  86
ASP A  90
ARG A  95
LYS A 162
THR A 163
 UNL  A 303 ( 4.7A)
UNX  A 302 ( 2.6A)
UNX  A 302 ( 3.2A)
UNX  A 302 ( 4.6A)
GER  A 301 ( 4.8A)
None
 1.00A 4kpdA-4fp4A:
20.8		 4kpdA-4fp4A:
23.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KPJ_A_210A901_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4fp4 POLYPRENYL
SYNTHETASE
(Pyrobaculum
calidifontis) 		6 / 9 ASP A  86
ASP A  90
ARG A  95
LYS A 162
THR A 163
GLN A 199
 UNX  A 302 ( 2.6A)
UNX  A 302 ( 3.2A)
UNX  A 302 ( 4.6A)
GER  A 301 ( 4.8A)
None
None
 1.14A 4kpjA-4fp4A:
20.3		 4kpjA-4fp4A:
24.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KPJ_A_210A901_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4fp4 POLYPRENYL
SYNTHETASE
(Pyrobaculum
calidifontis) 		6 / 9 LEU A  83
ASP A  86
ASP A  90
ARG A  95
LYS A 162
THR A 163
 UNL  A 303 ( 4.7A)
UNX  A 302 ( 2.6A)
UNX  A 302 ( 3.2A)
UNX  A 302 ( 4.6A)
GER  A 301 ( 4.8A)
None
 1.05A 4kpjA-4fp4A:
20.3		 4kpjA-4fp4A:
24.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KQ5_A_ZOLA404_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4fp4 POLYPRENYL
SYNTHETASE
(Pyrobaculum
calidifontis) 		5 / 10 ASP A  86
ASP A  90
ARG A  95
GLN A 147
THR A 163
 UNX  A 302 ( 2.6A)
UNX  A 302 ( 3.2A)
UNX  A 302 ( 4.6A)
GER  A 301 ( 4.7A)
None
 0.94A 4kq5A-4fp4A:
20.4		 4kq5A-4fp4A:
24.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KQ5_A_ZOLA404_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4fp4 POLYPRENYL
SYNTHETASE
(Pyrobaculum
calidifontis) 		6 / 10 ASP A  86
ASP A  90
ARG A  95
LYS A 162
THR A 163
GLN A 199
 UNX  A 302 ( 2.6A)
UNX  A 302 ( 3.2A)
UNX  A 302 ( 4.6A)
GER  A 301 ( 4.8A)
None
None
 1.18A 4kq5A-4fp4A:
20.4		 4kq5A-4fp4A:
24.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KQ5_A_ZOLA404_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4fp4 POLYPRENYL
SYNTHETASE
(Pyrobaculum
calidifontis) 		5 / 10 LEU A  83
ASP A  86
ARG A  95
LYS A 162
THR A 163
 UNL  A 303 ( 4.7A)
UNX  A 302 ( 2.6A)
UNX  A 302 ( 4.6A)
GER  A 301 ( 4.8A)
None
 1.11A 4kq5A-4fp4A:
20.4		 4kq5A-4fp4A:
24.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KQS_A_RISA405_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4fp4 POLYPRENYL
SYNTHETASE
(Pyrobaculum
calidifontis) 		6 / 10 ASP A  86
ASP A  90
ARG A  95
GLN A 147
THR A 163
GLN A 199
 UNX  A 302 ( 2.6A)
UNX  A 302 ( 3.2A)
UNX  A 302 ( 4.6A)
GER  A 301 ( 4.7A)
None
None
 1.08A 4kqsA-4fp4A:
20.8		 4kqsA-4fp4A:
24.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KQS_A_RISA405_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4fp4 POLYPRENYL
SYNTHETASE
(Pyrobaculum
calidifontis) 		6 / 10 ASP A  86
ASP A  90
ARG A  95
LYS A 162
THR A 163
GLN A 199
 UNX  A 302 ( 2.6A)
UNX  A 302 ( 3.2A)
UNX  A 302 ( 4.6A)
GER  A 301 ( 4.8A)
None
None
 1.14A 4kqsA-4fp4A:
20.8		 4kqsA-4fp4A:
24.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KQS_A_RISA405_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4fp4 POLYPRENYL
SYNTHETASE
(Pyrobaculum
calidifontis) 		6 / 10 LEU A  83
ASP A  86
ASP A  90
ARG A  95
LYS A 162
THR A 163
 UNL  A 303 ( 4.7A)
UNX  A 302 ( 2.6A)
UNX  A 302 ( 3.2A)
UNX  A 302 ( 4.6A)
GER  A 301 ( 4.8A)
None
 1.03A 4kqsA-4fp4A:
20.8		 4kqsA-4fp4A:
24.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N9U_A_RISA404_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4fp4 POLYPRENYL
SYNTHETASE
(Pyrobaculum
calidifontis) 		5 / 10 ASP A  86
ASP A  90
ARG A  95
GLN A 147
THR A 163
 UNX  A 302 ( 2.6A)
UNX  A 302 ( 3.2A)
UNX  A 302 ( 4.6A)
GER  A 301 ( 4.7A)
None
 1.02A 4n9uA-4fp4A:
20.8		 4n9uA-4fp4A:
23.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NG6_A_RISA405_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4fp4 POLYPRENYL
SYNTHETASE
(Pyrobaculum
calidifontis) 		6 / 12 ASP A  86
ASP A  90
ARG A  95
GLN A 147
THR A 163
GLN A 199
 UNX  A 302 ( 2.6A)
UNX  A 302 ( 3.2A)
UNX  A 302 ( 4.6A)
GER  A 301 ( 4.7A)
None
None
 0.86A 4ng6A-4fp4A:
20.4		 4ng6A-4fp4A:
23.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKE_A_RISA404_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4fp4 POLYPRENYL
SYNTHETASE
(Pyrobaculum
calidifontis) 		5 / 10 ASP A  86
ASP A  90
ARG A  95
GLN A 147
THR A 163
 UNX  A 302 ( 2.6A)
UNX  A 302 ( 3.2A)
UNX  A 302 ( 4.6A)
GER  A 301 ( 4.7A)
None
 0.97A 4nkeA-4fp4A:
20.6		 4nkeA-4fp4A:
24.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKE_A_RISA404_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4fp4 POLYPRENYL
SYNTHETASE
(Pyrobaculum
calidifontis) 		6 / 10 LEU A  83
ASP A  86
ASP A  90
ARG A  95
LYS A 162
THR A 163
 UNL  A 303 ( 4.7A)
UNX  A 302 ( 2.6A)
UNX  A 302 ( 3.2A)
UNX  A 302 ( 4.6A)
GER  A 301 ( 4.8A)
None
 1.02A 4nkeA-4fp4A:
20.6		 4nkeA-4fp4A:
24.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKF_A_210A404_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4fp4 POLYPRENYL
SYNTHETASE
(Pyrobaculum
calidifontis) 		6 / 9 ASP A  86
ASP A  90
ARG A  95
LYS A 162
THR A 163
GLN A 199
 UNX  A 302 ( 2.6A)
UNX  A 302 ( 3.2A)
UNX  A 302 ( 4.6A)
GER  A 301 ( 4.8A)
None
None
 1.14A 4nkfA-4fp4A:
20.7		 4nkfA-4fp4A:
24.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKF_A_210A404_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4fp4 POLYPRENYL
SYNTHETASE
(Pyrobaculum
calidifontis) 		6 / 9 LEU A  83
ASP A  86
ASP A  90
ARG A  95
LYS A 162
THR A 163
 UNL  A 303 ( 4.7A)
UNX  A 302 ( 2.6A)
UNX  A 302 ( 3.2A)
UNX  A 302 ( 4.6A)
GER  A 301 ( 4.8A)
None
 1.05A 4nkfA-4fp4A:
20.7		 4nkfA-4fp4A:
24.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NUA_A_RISA901_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4fp4 POLYPRENYL
SYNTHETASE
(Pyrobaculum
calidifontis) 		5 / 10 ASP A  86
ASP A  90
ARG A  95
GLN A 147
THR A 163
 UNX  A 302 ( 2.6A)
UNX  A 302 ( 3.2A)
UNX  A 302 ( 4.6A)
GER  A 301 ( 4.7A)
None
 0.95A 4nuaA-4fp4A:
20.7		 4nuaA-4fp4A:
24.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NUA_A_RISA901_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4fp4 POLYPRENYL
SYNTHETASE
(Pyrobaculum
calidifontis) 		6 / 10 ASP A  86
ASP A  90
ARG A  95
LYS A 162
THR A 163
GLN A 199
 UNX  A 302 ( 2.6A)
UNX  A 302 ( 3.2A)
UNX  A 302 ( 4.6A)
GER  A 301 ( 4.8A)
None
None
 1.13A 4nuaA-4fp4A:
20.7		 4nuaA-4fp4A:
24.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NUA_A_RISA901_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4fp4 POLYPRENYL
SYNTHETASE
(Pyrobaculum
calidifontis) 		6 / 10 LEU A  83
ASP A  86
ASP A  90
ARG A  95
LYS A 162
THR A 163
 UNL  A 303 ( 4.7A)
UNX  A 302 ( 2.6A)
UNX  A 302 ( 3.2A)
UNX  A 302 ( 4.6A)
GER  A 301 ( 4.8A)
None
 1.04A 4nuaA-4fp4A:
20.7		 4nuaA-4fp4A:
24.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OGU_A_210A405_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4fp4 POLYPRENYL
SYNTHETASE
(Pyrobaculum
calidifontis) 		6 / 9 ASP A  86
ASP A  90
ARG A  95
LYS A 162
THR A 163
GLN A 199
 UNX  A 302 ( 2.6A)
UNX  A 302 ( 3.2A)
UNX  A 302 ( 4.6A)
GER  A 301 ( 4.8A)
None
None
 1.16A 4oguA-4fp4A:
20.3		 4oguA-4fp4A:
24.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OGU_A_210A405_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4fp4 POLYPRENYL
SYNTHETASE
(Pyrobaculum
calidifontis) 		6 / 9 LEU A  83
ASP A  86
ASP A  90
ARG A  95
LYS A 162
THR A 163
 UNL  A 303 ( 4.7A)
UNX  A 302 ( 2.6A)
UNX  A 302 ( 3.2A)
UNX  A 302 ( 4.6A)
GER  A 301 ( 4.8A)
None
 1.07A 4oguA-4fp4A:
20.3		 4oguA-4fp4A:
24.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P0V_A_ZOLA401_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4fp4 POLYPRENYL
SYNTHETASE
(Pyrobaculum
calidifontis) 		6 / 9 ASP A  86
ASP A  90
ARG A  95
GLN A 147
THR A 163
GLN A 199
 UNX  A 302 ( 2.6A)
UNX  A 302 ( 3.2A)
UNX  A 302 ( 4.6A)
GER  A 301 ( 4.7A)
None
None
 1.03A 4p0vA-4fp4A:
20.9		 4p0vA-4fp4A:
24.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P0V_A_ZOLA401_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4fp4 POLYPRENYL
SYNTHETASE
(Pyrobaculum
calidifontis) 		6 / 9 ASP A  86
ASP A  90
ARG A  95
LYS A 162
THR A 163
GLN A 199
 UNX  A 302 ( 2.6A)
UNX  A 302 ( 3.2A)
UNX  A 302 ( 4.6A)
GER  A 301 ( 4.8A)
None
None
 1.14A 4p0vA-4fp4A:
20.9		 4p0vA-4fp4A:
24.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P0W_A_ZOLA501_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4fp4 POLYPRENYL
SYNTHETASE
(Pyrobaculum
calidifontis) 		5 / 11 ASP A  86
ASP A  90
ARG A  95
GLN A 147
THR A 163
 UNX  A 302 ( 2.6A)
UNX  A 302 ( 3.2A)
UNX  A 302 ( 4.6A)
GER  A 301 ( 4.7A)
None
 0.89A 4p0wA-4fp4A:
20.9		 4p0wA-4fp4A:
24.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P0W_A_ZOLA501_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4fp4 POLYPRENYL
SYNTHETASE
(Pyrobaculum
calidifontis) 		5 / 11 ASP A  86
ASP A  90
GLN A 147
THR A 163
GLN A 199
 UNX  A 302 ( 2.6A)
UNX  A 302 ( 3.2A)
GER  A 301 ( 4.7A)
None
None
 1.08A 4p0wA-4fp4A:
20.9		 4p0wA-4fp4A:
24.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P0W_A_ZOLA501_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4fp4 POLYPRENYL
SYNTHETASE
(Pyrobaculum
calidifontis) 		5 / 11 ASP A  86
ASP A  90
LYS A 162
THR A 163
GLN A 199
 UNX  A 302 ( 2.6A)
UNX  A 302 ( 3.2A)
GER  A 301 ( 4.8A)
None
None
 1.19A 4p0wA-4fp4A:
20.9		 4p0wA-4fp4A:
24.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P0W_A_ZOLA501_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4fp4 POLYPRENYL
SYNTHETASE
(Pyrobaculum
calidifontis) 		6 / 11 LEU A  83
ASP A  86
ASP A  90
ARG A  95
LYS A 162
THR A 163
 UNL  A 303 ( 4.7A)
UNX  A 302 ( 2.6A)
UNX  A 302 ( 3.2A)
UNX  A 302 ( 4.6A)
GER  A 301 ( 4.8A)
None
 1.06A 4p0wA-4fp4A:
20.9		 4p0wA-4fp4A:
24.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q23_A_RISA901_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4fp4 POLYPRENYL
SYNTHETASE
(Pyrobaculum
calidifontis) 		5 / 10 ASP A  86
ASP A  90
ARG A  95
LYS A 162
GLN A 199
 UNX  A 302 ( 2.6A)
UNX  A 302 ( 3.2A)
UNX  A 302 ( 4.6A)
GER  A 301 ( 4.8A)
None
 1.21A 4q23A-4fp4A:
19.0		 4q23A-4fp4A:
23.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q23_A_RISA901_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4fp4 POLYPRENYL
SYNTHETASE
(Pyrobaculum
calidifontis) 		5 / 10 LEU A  83
ASP A  86
ASP A  90
ARG A  95
LYS A 162
 UNL  A 303 ( 4.7A)
UNX  A 302 ( 2.6A)
UNX  A 302 ( 3.2A)
UNX  A 302 ( 4.6A)
GER  A 301 ( 4.8A)
 1.10A 4q23A-4fp4A:
19.0		 4q23A-4fp4A:
23.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RXD_A_RISA1404_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4fp4 POLYPRENYL
SYNTHETASE
(Pyrobaculum
calidifontis) 		6 / 10 ASP A  86
ASP A  90
ARG A  95
GLN A 147
THR A 163
GLN A 199
 UNX  A 302 ( 2.6A)
UNX  A 302 ( 3.2A)
UNX  A 302 ( 4.6A)
GER  A 301 ( 4.7A)
None
None
 1.13A 4rxdA-4fp4A:
20.1		 4rxdA-4fp4A:
23.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RXD_A_RISA1404_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4fp4 POLYPRENYL
SYNTHETASE
(Pyrobaculum
calidifontis) 		6 / 10 ASP A  86
ASP A  90
ARG A  95
LYS A 162
THR A 163
GLN A 199
 UNX  A 302 ( 2.6A)
UNX  A 302 ( 3.2A)
UNX  A 302 ( 4.6A)
GER  A 301 ( 4.8A)
None
None
 1.14A 4rxdA-4fp4A:
20.1		 4rxdA-4fp4A:
23.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RXD_A_RISA1404_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4fp4 POLYPRENYL
SYNTHETASE
(Pyrobaculum
calidifontis) 		6 / 10 LEU A  83
ASP A  86
ASP A  90
ARG A  95
LYS A 162
THR A 163
 UNL  A 303 ( 4.7A)
UNX  A 302 ( 2.6A)
UNX  A 302 ( 3.2A)
UNX  A 302 ( 4.6A)
GER  A 301 ( 4.8A)
None
 1.04A 4rxdA-4fp4A:
20.1		 4rxdA-4fp4A:
23.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RXD_B_RISB1504_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4fp4 POLYPRENYL
SYNTHETASE
(Pyrobaculum
calidifontis) 		6 / 10 ASP A  86
ASP A  90
ARG A  95
GLN A 147
THR A 163
GLN A 199
 UNX  A 302 ( 2.6A)
UNX  A 302 ( 3.2A)
UNX  A 302 ( 4.6A)
GER  A 301 ( 4.7A)
None
None
 1.12A 4rxdB-4fp4A:
20.4		 4rxdB-4fp4A:
23.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RXD_B_RISB1504_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4fp4 POLYPRENYL
SYNTHETASE
(Pyrobaculum
calidifontis) 		6 / 10 ASP A  86
ASP A  90
ARG A  95
LYS A 162
THR A 163
GLN A 199
 UNX  A 302 ( 2.6A)
UNX  A 302 ( 3.2A)
UNX  A 302 ( 4.6A)
GER  A 301 ( 4.8A)
None
None
 1.13A 4rxdB-4fp4A:
20.4		 4rxdB-4fp4A:
23.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RXD_B_RISB1504_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4fp4 POLYPRENYL
SYNTHETASE
(Pyrobaculum
calidifontis) 		6 / 10 LEU A  83
ASP A  86
ASP A  90
ARG A  95
LYS A 162
THR A 163
 UNL  A 303 ( 4.7A)
UNX  A 302 ( 2.6A)
UNX  A 302 ( 3.2A)
UNX  A 302 ( 4.6A)
GER  A 301 ( 4.8A)
None
 1.04A 4rxdB-4fp4A:
20.4		 4rxdB-4fp4A:
23.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RXD_C_RISC1600_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4fp4 POLYPRENYL
SYNTHETASE
(Pyrobaculum
calidifontis) 		6 / 10 ASP A  86
ASP A  90
ARG A  95
GLN A 147
THR A 163
GLN A 199
 UNX  A 302 ( 2.6A)
UNX  A 302 ( 3.2A)
UNX  A 302 ( 4.6A)
GER  A 301 ( 4.7A)
None
None
 1.13A 4rxdC-4fp4A:
20.4		 4rxdC-4fp4A:
23.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RXD_C_RISC1600_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4fp4 POLYPRENYL
SYNTHETASE
(Pyrobaculum
calidifontis) 		6 / 10 ASP A  86
ASP A  90
ARG A  95
LYS A 162
THR A 163
GLN A 199
 UNX  A 302 ( 2.6A)
UNX  A 302 ( 3.2A)
UNX  A 302 ( 4.6A)
GER  A 301 ( 4.8A)
None
None
 1.14A 4rxdC-4fp4A:
20.4		 4rxdC-4fp4A:
23.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RXD_C_RISC1600_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4fp4 POLYPRENYL
SYNTHETASE
(Pyrobaculum
calidifontis) 		6 / 10 LEU A  83
ASP A  86
ASP A  90
ARG A  95
LYS A 162
THR A 163
 UNL  A 303 ( 4.7A)
UNX  A 302 ( 2.6A)
UNX  A 302 ( 3.2A)
UNX  A 302 ( 4.6A)
GER  A 301 ( 4.8A)
None
 1.04A 4rxdC-4fp4A:
20.4		 4rxdC-4fp4A:
23.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UMJ_A_BFQA1297_1
(GERANYLTRANSTRANSFER
ASE)		 4fp4 POLYPRENYL
SYNTHETASE
(Pyrobaculum
calidifontis) 		5 / 8 SER A  82
ASP A  86
ASP A  90
ARG A  95
GLN A 147
 GER  A 301 (-4.5A)
UNX  A 302 ( 2.6A)
UNX  A 302 ( 3.2A)
UNX  A 302 ( 4.6A)
GER  A 301 ( 4.7A)
 0.71A 4umjA-4fp4A:
24.8		 4umjA-4fp4A:
29.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UMJ_A_BFQA1297_1
(GERANYLTRANSTRANSFER
ASE)		 4fp4 POLYPRENYL
SYNTHETASE
(Pyrobaculum
calidifontis) 		6 / 8 SER A  82
LEU A  83
ASP A  86
ASP A  90
ARG A  95
LYS A 162
 GER  A 301 (-4.5A)
UNL  A 303 ( 4.7A)
UNX  A 302 ( 2.6A)
UNX  A 302 ( 3.2A)
UNX  A 302 ( 4.6A)
GER  A 301 ( 4.8A)
 0.92A 4umjA-4fp4A:
24.8		 4umjA-4fp4A:
29.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UMJ_B_BFQB1294_1
(GERANYLTRANSTRANSFER
ASE)		 4fp4 POLYPRENYL
SYNTHETASE
(Pyrobaculum
calidifontis) 		5 / 9 ASP A  86
ASP A  90
ARG A  95
GLN A 147
THR A 163
 UNX  A 302 ( 2.6A)
UNX  A 302 ( 3.2A)
UNX  A 302 ( 4.6A)
GER  A 301 ( 4.7A)
None
 0.90A 4umjB-4fp4A:
24.6		 4umjB-4fp4A:
29.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UMJ_B_BFQB1294_1
(GERANYLTRANSTRANSFER
ASE)		 4fp4 POLYPRENYL
SYNTHETASE
(Pyrobaculum
calidifontis) 		7 / 9 SER A  82
LEU A  83
ASP A  86
ASP A  90
ARG A  95
LYS A 162
THR A 163
 GER  A 301 (-4.5A)
UNL  A 303 ( 4.7A)
UNX  A 302 ( 2.6A)
UNX  A 302 ( 3.2A)
UNX  A 302 ( 4.6A)
GER  A 301 ( 4.8A)
None
 0.94A 4umjB-4fp4A:
24.6		 4umjB-4fp4A:
29.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CG5_A_RISA400_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4fp4 POLYPRENYL
SYNTHETASE
(Pyrobaculum
calidifontis) 		6 / 12 ASP A  86
ASP A  90
ARG A  95
GLN A 147
THR A 163
GLN A 199
 UNX  A 302 ( 2.6A)
UNX  A 302 ( 3.2A)
UNX  A 302 ( 4.6A)
GER  A 301 ( 4.7A)
None
None
 1.04A 5cg5A-4fp4A:
20.6		 5cg5A-4fp4A:
25.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CG5_A_RISA400_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4fp4 POLYPRENYL
SYNTHETASE
(Pyrobaculum
calidifontis) 		6 / 12 ASP A  86
ASP A  90
ARG A  95
LYS A 162
THR A 163
GLN A 199
 UNX  A 302 ( 2.6A)
UNX  A 302 ( 3.2A)
UNX  A 302 ( 4.6A)
GER  A 301 ( 4.8A)
None
None
 1.12A 5cg5A-4fp4A:
20.6		 5cg5A-4fp4A:
25.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CG5_A_RISA400_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4fp4 POLYPRENYL
SYNTHETASE
(Pyrobaculum
calidifontis) 		6 / 12 LEU A  83
ASP A  86
ASP A  90
ARG A  95
LYS A 162
THR A 163
 UNL  A 303 ( 4.7A)
UNX  A 302 ( 2.6A)
UNX  A 302 ( 3.2A)
UNX  A 302 ( 4.6A)
GER  A 301 ( 4.8A)
None
 1.03A 5cg5A-4fp4A:
20.6		 5cg5A-4fp4A:
25.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CG6_A_RISA404_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4fp4 POLYPRENYL
SYNTHETASE
(Pyrobaculum
calidifontis) 		6 / 12 ASP A  86
ASP A  90
ARG A  95
GLN A 147
THR A 163
GLN A 199
 UNX  A 302 ( 2.6A)
UNX  A 302 ( 3.2A)
UNX  A 302 ( 4.6A)
GER  A 301 ( 4.7A)
None
None
 1.06A 5cg6A-4fp4A:
20.9		 5cg6A-4fp4A:
25.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CG6_A_RISA404_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4fp4 POLYPRENYL
SYNTHETASE
(Pyrobaculum
calidifontis) 		6 / 12 ASP A  86
ASP A  90
ARG A  95
LYS A 162
THR A 163
GLN A 199
 UNX  A 302 ( 2.6A)
UNX  A 302 ( 3.2A)
UNX  A 302 ( 4.6A)
GER  A 301 ( 4.8A)
None
None
 1.12A 5cg6A-4fp4A:
20.9		 5cg6A-4fp4A:
25.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CG6_A_RISA404_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4fp4 POLYPRENYL
SYNTHETASE
(Pyrobaculum
calidifontis) 		6 / 12 LEU A  83
ASP A  86
ASP A  90
ARG A  95
LYS A 162
THR A 163
 UNL  A 303 ( 4.7A)
UNX  A 302 ( 2.6A)
UNX  A 302 ( 3.2A)
UNX  A 302 ( 4.6A)
GER  A 301 ( 4.8A)
None
 1.02A 5cg6A-4fp4A:
20.9		 5cg6A-4fp4A:
25.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ERO_A_210A804_1
(FUSICOCCADIENE
SYNTHASE)		 4fp4 POLYPRENYL
SYNTHETASE
(Pyrobaculum
calidifontis) 		6 / 9 LEU A  83
ASP A  86
ASP A  90
ARG A  95
LYS A 162
GLN A 199
 UNL  A 303 ( 4.7A)
UNX  A 302 ( 2.6A)
UNX  A 302 ( 3.2A)
UNX  A 302 ( 4.6A)
GER  A 301 ( 4.8A)
None
 1.19A 5eroA-4fp4A:
19.9		 5eroA-4fp4A:
23.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ERO_B_210B804_1
(FUSICOCCADIENE
SYNTHASE)		 4fp4 POLYPRENYL
SYNTHETASE
(Pyrobaculum
calidifontis) 		5 / 9 ASP A  86
ASP A  90
ARG A  95
LYS A 162
GLN A 199
 UNX  A 302 ( 2.6A)
UNX  A 302 ( 3.2A)
UNX  A 302 ( 4.6A)
GER  A 301 ( 4.8A)
None
 1.26A 5eroB-4fp4A:
19.9		 5eroB-4fp4A:
23.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HIE_B_P06B801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 1vg0 RAB PROTEINS
GERANYLGERANYLTRANSF
ERASE COMPONENT A 1
(Rattus
norvegicus) 		5 / 12 VAL A 271
ALA A 262
PHE A 370
ILE A 471
THR A 473
 GER  A 952 ( 4.8A)
None
None
None
None
 0.74A 5hieB-1vg0A:
undetectable		 5hieB-1vg0A:
16.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGY_A_ERYA403_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)		 1hh4 RHO GDP-DISSOCIATION
INHIBITOR 1
(Homo
sapiens) 		4 / 6 ASP D 440
ILE D 429
TYR D 428
TYR D 410
 None
None
None
GER  D1502 (-4.9A)
 1.29A 5igyA-1hh4D:
undetectable		 5igyA-1hh4D:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IH0_A_ERYA404_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)		 1hh4 RHO GDP-DISSOCIATION
INHIBITOR 1
(Homo
sapiens) 		4 / 6 ASP D 440
ILE D 429
TYR D 428
TYR D 410
 None
None
None
GER  D1502 (-4.9A)
 1.25A 5ih0A-1hh4D:
0.0		 5ih0A-1hh4D:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6G31_A_ZOLA401_0
(GERANYLGERANYL
PYROPHOSPHATE
SYNTHASE)		 4fp4 POLYPRENYL
SYNTHETASE
(Pyrobaculum
calidifontis) 		5 / 7 ASP A  86
ASP A  90
ARG A  95
GLN A 147
GLN A 199
 UNX  A 302 ( 2.6A)
UNX  A 302 ( 3.2A)
UNX  A 302 ( 4.6A)
GER  A 301 ( 4.7A)
None
 1.00A 6g31A-4fp4A:
19.1		 6g31A-4fp4A:
13.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6G31_B_ZOLB401_0
(GERANYLGERANYL
PYROPHOSPHATE
SYNTHASE)		 4fp4 POLYPRENYL
SYNTHETASE
(Pyrobaculum
calidifontis) 		5 / 6 ASP A  86
ASP A  90
ARG A  95
GLN A 147
GLN A 199
 UNX  A 302 ( 2.6A)
UNX  A 302 ( 3.2A)
UNX  A 302 ( 4.6A)
GER  A 301 ( 4.7A)
None
 0.93A 6g31B-4fp4A:
18.7		 6g31B-4fp4A:
13.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6G31_C_ZOLC401_0
(GERANYLGERANYL
PYROPHOSPHATE
SYNTHASE)		 4fp4 POLYPRENYL
SYNTHETASE
(Pyrobaculum
calidifontis) 		4 / 5 ASP A  86
ARG A  95
GLN A 147
LYS A 162
 UNX  A 302 ( 2.6A)
UNX  A 302 ( 4.6A)
GER  A 301 ( 4.7A)
GER  A 301 ( 4.8A)
 1.33A 6g31C-4fp4A:
19.1		 6g31C-4fp4A:
13.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6G31_C_ZOLC401_0
(GERANYLGERANYL
PYROPHOSPHATE
SYNTHASE)		 4fp4 POLYPRENYL
SYNTHETASE
(Pyrobaculum
calidifontis) 		4 / 5 ASP A  86
ASP A  90
ARG A  95
GLN A 147
 UNX  A 302 ( 2.6A)
UNX  A 302 ( 3.2A)
UNX  A 302 ( 4.6A)
GER  A 301 ( 4.7A)
 0.90A 6g31C-4fp4A:
19.1		 6g31C-4fp4A:
13.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6G31_D_ZOLD401_0
(GERANYLGERANYL
PYROPHOSPHATE
SYNTHASE)		 4fp4 POLYPRENYL
SYNTHETASE
(Pyrobaculum
calidifontis) 		5 / 7 ASP A  86
ASP A  90
ARG A  95
GLN A 147
GLN A 199
 UNX  A 302 ( 2.6A)
UNX  A 302 ( 3.2A)
UNX  A 302 ( 4.6A)
GER  A 301 ( 4.7A)
None
 0.96A 6g31D-4fp4A:
15.0		 6g31D-4fp4A:
13.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6G31_F_ZOLF401_0
(GERANYLGERANYL
PYROPHOSPHATE
SYNTHASE)		 4fp4 POLYPRENYL
SYNTHETASE
(Pyrobaculum
calidifontis) 		4 / 5 ASP A  86
ASP A  90
GLN A 147
GLN A 199
 UNX  A 302 ( 2.6A)
UNX  A 302 ( 3.2A)
GER  A 301 ( 4.7A)
None
 0.94A 6g31F-4fp4A:
18.5		 6g31F-4fp4A:
13.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6G31_F_ZOLF401_0
(GERANYLGERANYL
PYROPHOSPHATE
SYNTHASE)		 4fp4 POLYPRENYL
SYNTHETASE
(Pyrobaculum
calidifontis) 		4 / 5 ASP A  90
ARG A  95
GLN A 147
GLN A 199
 UNX  A 302 ( 3.2A)
UNX  A 302 ( 4.6A)
GER  A 301 ( 4.7A)
None
 1.07A 6g31F-4fp4A:
18.5		 6g31F-4fp4A:
13.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6G31_G_ZOLG401_0
(GERANYLGERANYL
PYROPHOSPHATE
SYNTHASE)		 4fp4 POLYPRENYL
SYNTHETASE
(Pyrobaculum
calidifontis) 		4 / 7 ASP A  86
ASP A  90
ARG A  95
GLN A 147
 UNX  A 302 ( 2.6A)
UNX  A 302 ( 3.2A)
UNX  A 302 ( 4.6A)
GER  A 301 ( 4.7A)
 0.64A 6g31G-4fp4A:
14.9		 6g31G-4fp4A:
13.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6G31_G_ZOLG401_0
(GERANYLGERANYL
PYROPHOSPHATE
SYNTHASE)		 4fp4 POLYPRENYL
SYNTHETASE
(Pyrobaculum
calidifontis) 		4 / 7 ASP A  86
ASP A  90
ARG A  95
LYS A 162
 UNX  A 302 ( 2.6A)
UNX  A 302 ( 3.2A)
UNX  A 302 ( 4.6A)
GER  A 301 ( 4.8A)
 1.13A 6g31G-4fp4A:
14.9		 6g31G-4fp4A:
13.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6G31_H_ZOLH401_0
(GERANYLGERANYL
PYROPHOSPHATE
SYNTHASE)		 4fp4 POLYPRENYL
SYNTHETASE
(Pyrobaculum
calidifontis) 		4 / 5 ASP A  86
ASP A  90
GLN A 147
GLN A 199
 UNX  A 302 ( 2.6A)
UNX  A 302 ( 3.2A)
GER  A 301 ( 4.7A)
None
 0.89A 6g31H-4fp4A:
18.4		 6g31H-4fp4A:
13.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6G31_J_ZOLJ401_0
(GERANYLGERANYL
PYROPHOSPHATE
SYNTHASE)		 4fp4 POLYPRENYL
SYNTHETASE
(Pyrobaculum
calidifontis) 		5 / 6 ASP A  86
ASP A  90
ARG A  95
GLN A 147
GLN A 199
 UNX  A 302 ( 2.6A)
UNX  A 302 ( 3.2A)
UNX  A 302 ( 4.6A)
GER  A 301 ( 4.7A)
None
 0.96A 6g31J-4fp4A:
18.5		 6g31J-4fp4A:
13.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6G31_K_ZOLK401_0
(GERANYLGERANYL
PYROPHOSPHATE
SYNTHASE)		 4fp4 POLYPRENYL
SYNTHETASE
(Pyrobaculum
calidifontis) 		4 / 4 ASP A  86
ASP A  90
ARG A  95
GLN A 147
 UNX  A 302 ( 2.6A)
UNX  A 302 ( 3.2A)
UNX  A 302 ( 4.6A)
GER  A 301 ( 4.7A)
 0.71A 6g31K-4fp4A:
18.1		 6g31K-4fp4A:
13.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6G31_L_ZOLL401_0
(GERANYLGERANYL
PYROPHOSPHATE
SYNTHASE)		 4fp4 POLYPRENYL
SYNTHETASE
(Pyrobaculum
calidifontis) 		5 / 6 ASP A  86
ASP A  90
ARG A  95
GLN A 147
GLN A 199
 UNX  A 302 ( 2.6A)
UNX  A 302 ( 3.2A)
UNX  A 302 ( 4.6A)
GER  A 301 ( 4.7A)
None
 0.94A 6g31L-4fp4A:
19.3		 6g31L-4fp4A:
13.62