SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'GEK'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VQ1_A_SAMA301_1
(N5-GLUTAMINE
METHYLTRANSFERASE,
HEMK)		 4gek TRNA
(CMO5U34)-METHYLTRAN
SFERASE
(Escherichia
coli) 		3 / 3 GLY A  64
ASP A  89
ASN A 132
 GEK  A 302 (-3.7A)
GEK  A 302 (-2.8A)
GEK  A 302 (-3.7A)
 0.61A 1vq1A-4gekA:
12.2		 1vq1A-4gekA:
24.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VQ1_A_SAMA301_1
(N5-GLUTAMINE
METHYLTRANSFERASE,
HEMK)		 4iwn TRNA
(CMO5U34)-METHYLTRAN
SFERASE
(Escherichia
coli) 		3 / 3 GLY A  64
ASP A  89
ASN A 132
 GEK  A 301 (-3.6A)
GEK  A 301 (-2.8A)
GEK  A 301 (-3.7A)
 0.59A 1vq1A-4iwnA:
12.4		 1vq1A-4iwnA:
22.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YC5_A_NCAA2001_0
(NAD-DEPENDENT
DEACETYLASE)		 4gek TRNA
(CMO5U34)-METHYLTRAN
SFERASE
(Escherichia
coli) 		4 / 7 ALA A  70
SER A  73
ASP A  62
ILE A  42
 GEK  A 302 ( 4.1A)
None
GEK  A 302 ( 4.5A)
None
 0.93A 1yc5A-4gekA:
2.8		 1yc5A-4gekA:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YC5_A_NCAA2001_0
(NAD-DEPENDENT
DEACETYLASE)		 4iwn TRNA
(CMO5U34)-METHYLTRAN
SFERASE
(Escherichia
coli) 		4 / 7 ALA A  70
SER A  73
ASP A  62
ILE A  42
 GEK  A 301 ( 4.1A)
None
GEK  A 301 ( 4.5A)
None
 0.88A 1yc5A-4iwnA:
2.9		 1yc5A-4iwnA:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2O4N_A_TPVA300_1
(PROTEASE)		 4gek TRNA
(CMO5U34)-METHYLTRAN
SFERASE
(Escherichia
coli) 		5 / 12 LEU A 147
ASP A 117
ILE A  88
GLY A  64
LEU A 160
 None
GEK  A 302 (-3.2A)
None
GEK  A 302 (-3.7A)
None
 0.99A 2o4nA-4gekA:
undetectable		 2o4nA-4gekA:
15.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RF4_A_FUNA201_1
(MACROPHAGE MIGRATION
INHIBITORY FACTOR)		 4gek TRNA
(CMO5U34)-METHYLTRAN
SFERASE
(Escherichia
coli) 		5 / 11 SER A 196
ILE A 195
VAL A  27
PHE A  28
VAL A  24
 None
None
None
GEK  A 302 (-4.9A)
None
 1.38A 3rf4A-4gekA:
undetectable
3rf4C-4gekA:
undetectable		 3rf4A-4gekA:
20.23
3rf4C-4gekA:
20.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RF4_B_FUNB202_1
(MACROPHAGE MIGRATION
INHIBITORY FACTOR)		 4gek TRNA
(CMO5U34)-METHYLTRAN
SFERASE
(Escherichia
coli) 		5 / 11 SER A 196
ILE A 195
VAL A  27
PHE A  28
VAL A  24
 None
None
None
GEK  A 302 (-4.9A)
None
 1.35A 3rf4A-4gekA:
undetectable
3rf4B-4gekA:
undetectable		 3rf4A-4gekA:
20.23
3rf4B-4gekA:
20.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RF4_C_FUNC203_1
(MACROPHAGE MIGRATION
INHIBITORY FACTOR)		 4gek TRNA
(CMO5U34)-METHYLTRAN
SFERASE
(Escherichia
coli) 		5 / 11 SER A 196
ILE A 195
VAL A  27
PHE A  28
VAL A  24
 None
None
None
GEK  A 302 (-4.9A)
None
 1.35A 3rf4B-4gekA:
undetectable
3rf4C-4gekA:
undetectable		 3rf4B-4gekA:
20.23
3rf4C-4gekA:
20.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IV8_A_SAMA301_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE,
PUTATIVE)		 4gek TRNA
(CMO5U34)-METHYLTRAN
SFERASE
(Escherichia
coli) 		5 / 12 GLY A  64
ASP A  89
MET A  94
ASP A 117
LEU A 138
 GEK  A 302 (-3.7A)
GEK  A 302 (-2.8A)
GEK  A 302 (-4.6A)
GEK  A 302 (-3.2A)
None
 0.72A 4iv8A-4gekA:
17.9		 4iv8A-4gekA:
25.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IV8_A_SAMA301_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE,
PUTATIVE)		 4iwn TRNA
(CMO5U34)-METHYLTRAN
SFERASE
(Escherichia
coli) 		6 / 12 GLY A  64
ASP A  89
MET A  94
ASP A 117
ILE A 118
LEU A 138
 GEK  A 301 (-3.6A)
GEK  A 301 (-2.8A)
GEK  A 301 ( 4.1A)
GEK  A 301 (-3.2A)
GEK  A 301 (-3.7A)
None
 0.92A 4iv8A-4iwnA:
18.4		 4iv8A-4iwnA:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IV8_B_SAMB301_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE,
PUTATIVE)		 4iwn TRNA
(CMO5U34)-METHYLTRAN
SFERASE
(Escherichia
coli) 		6 / 12 GLY A  64
ASP A  89
MET A  94
ASP A 117
ILE A 118
LEU A 138
 GEK  A 301 (-3.6A)
GEK  A 301 (-2.8A)
GEK  A 301 ( 4.1A)
GEK  A 301 (-3.2A)
GEK  A 301 (-3.7A)
None
 0.96A 4iv8B-4iwnA:
18.3		 4iv8B-4iwnA:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DPD_B_SAMB601_0
(PROTEIN LYSINE
METHYLTRANSFERASE 1)		 4iwn TRNA
(CMO5U34)-METHYLTRAN
SFERASE
(Escherichia
coli) 		5 / 12 TYR A  39
GLY A  64
ASP A  89
SER A  91
ILE A 118
 GEK  A 301 (-4.7A)
GEK  A 301 (-3.6A)
GEK  A 301 (-2.8A)
GEK  A 301 (-4.6A)
GEK  A 301 (-3.7A)
 1.13A 5dpdB-4iwnA:
14.8		 5dpdB-4iwnA:
18.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IL1_A_SAMA601_0
(METTL3)		 4gek TRNA
(CMO5U34)-METHYLTRAN
SFERASE
(Escherichia
coli) 		5 / 12 ASP A 117
ILE A 118
ARG A 119
LEU A 138
GLY A  64
 GEK  A 302 (-3.2A)
GEK  A 302 (-3.8A)
None
None
GEK  A 302 (-3.7A)
 1.02A 5il1A-4gekA:
4.1		 5il1A-4gekA:
19.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5K7U_A_SAMA601_0
(N6-ADENOSINE-METHYLT
RANSFERASE 70 KDA
SUBUNIT)		 4gek TRNA
(CMO5U34)-METHYLTRAN
SFERASE
(Escherichia
coli) 		5 / 12 ASP A 117
ILE A 118
ARG A 119
ASN A 132
GLY A  64
 GEK  A 302 (-3.2A)
GEK  A 302 (-3.8A)
None
GEK  A 302 (-3.7A)
GEK  A 302 (-3.7A)
 1.16A 5k7uA-4gekA:
1.4		 5k7uA-4gekA:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5K7U_A_SAMA601_0
(N6-ADENOSINE-METHYLT
RANSFERASE 70 KDA
SUBUNIT)		 4gek TRNA
(CMO5U34)-METHYLTRAN
SFERASE
(Escherichia
coli) 		5 / 12 ASP A 117
ILE A 118
ARG A 119
LEU A 138
GLY A  64
 GEK  A 302 (-3.2A)
GEK  A 302 (-3.8A)
None
None
GEK  A 302 (-3.7A)
 1.09A 5k7uA-4gekA:
1.4		 5k7uA-4gekA:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KB6_A_ADNA401_1
(ADENOSINE KINASE)		 4gek TRNA
(CMO5U34)-METHYLTRAN
SFERASE
(Escherichia
coli) 		5 / 12 THR A 134
ALA A  69
GLY A  68
ALA A  70
ILE A  43
 GEK  A 302 ( 3.8A)
SO4  A 301 (-3.7A)
None
GEK  A 302 ( 4.1A)
None
 0.86A 5kb6A-4gekA:
3.9		 5kb6A-4gekA:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KB6_A_ADNA401_1
(ADENOSINE KINASE)		 4iwn TRNA
(CMO5U34)-METHYLTRAN
SFERASE
(Escherichia
coli) 		5 / 12 THR A 134
ALA A  69
GLY A  68
ALA A  70
ILE A  43
 GEK  A 301 ( 3.8A)
GEK  A 301 (-3.6A)
None
GEK  A 301 ( 4.1A)
None
 0.90A 5kb6A-4iwnA:
3.8		 5kb6A-4iwnA:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BQ4_B_ADNB401_1
(THERMOSPERMINE
SYNTHASE ACAULIS
PROTEIN)		 4gek TRNA
(CMO5U34)-METHYLTRAN
SFERASE
(Escherichia
coli) 		5 / 12 GLY A  68
ASP A  62
ILE A  85
VAL A 130
LEU A  72
 None
GEK  A 302 ( 4.5A)
None
None
SO4  A 301 ( 4.0A)
 1.07A 6bq4B-4gekA:
12.1		 6bq4B-4gekA:
18.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FGC_A_ACTA811_0
(GEPHYRIN)		 4iwn TRNA
(CMO5U34)-METHYLTRAN
SFERASE
(Escherichia
coli) 		3 / 3 LEU A 146
LEU A 138
ARG A 119
 None
None
GEK  A 301 ( 3.6A)
 0.70A 6fgcA-4iwnA:
undetectable		 6fgcA-4iwnA:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FGD_A_ACTA810_0
(GEPHYRIN)		 4iwn TRNA
(CMO5U34)-METHYLTRAN
SFERASE
(Escherichia
coli) 		3 / 3 LEU A 146
LEU A 138
ARG A 119
 None
None
GEK  A 301 ( 3.6A)
 0.68A 6fgdA-4iwnA:
2.4		 6fgdA-4iwnA:
20.95