SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'GDU'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AOX_B_THAB401_1
(HISTAMINE
N-METHYLTRANSFERASE)		 3aw9 NAD-DEPENDENT
EPIMERASE/DEHYDRATAS
E
(Pyrobaculum
calidifontis) 		4 / 7 PHE A 176
GLN A 195
TYR A 199
TRP A 265
 GDU  A 801 (-4.7A)
GDU  A 801 (-4.1A)
GDU  A 801 (-4.1A)
None
 1.28A 2aoxB-3aw9A:
3.9		 2aoxB-3aw9A:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q63_A_1UNA1001_2
(PROTEASE RETROPEPSIN)		 3aw9 NAD-DEPENDENT
EPIMERASE/DEHYDRATAS
E
(Pyrobaculum
calidifontis) 		3 / 3 ARG A 203
ASN A 162
THR A 298
 None
GDU  A 801 ( 2.7A)
None
 0.70A 2q63A-3aw9A:
undetectable		 2q63A-3aw9A:
13.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2UZ2_A_ACTA1123_0
(XENAVIDIN)		 3hdy UDP-GALACTOPYRANOSE
MUTASE
(Deinococcus
radiodurans) 		4 / 7 LEU A 191
SER A 159
THR A 196
VAL A 195
 None
None
GDU  A 500 (-4.6A)
GDU  A 500 (-4.9A)
 1.17A 2uz2A-3hdyA:
undetectable		 2uz2A-3hdyA:
15.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VMY_A_GLYA502_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 4rph UDP-GALACTOPYRANOSE
MUTASE
(Mycobacterium
tuberculosis) 		4 / 7 HIS B  65
HIS B 294
ARG B 292
TYR B 328
 FAD  B 401 (-3.5A)
None
GDU  B 402 (-2.7A)
GDU  B 402 ( 4.6A)
 1.32A 2vmyA-4rphB:
undetectable
2vmyB-4rphB:
undetectable		 2vmyA-4rphB:
21.91
2vmyB-4rphB:
21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VMY_B_GLYB502_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 4rph UDP-GALACTOPYRANOSE
MUTASE
(Mycobacterium
tuberculosis) 		4 / 8 TYR B 328
HIS B  65
HIS B 294
ARG B 292
 GDU  B 402 ( 4.6A)
FAD  B 401 (-3.5A)
None
GDU  B 402 (-2.7A)
 1.26A 2vmyA-4rphB:
undetectable
2vmyB-4rphB:
undetectable		 2vmyA-4rphB:
21.91
2vmyB-4rphB:
21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B2R_A_VDNA1_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		 3ukf UDP-GALACTOPYRANOSE
MUTASE
(Aspergillus
fumigatus) 		5 / 12 LEU A 157
ALA A 155
ILE A 154
GLN A 107
PHE A 106
 None
None
None
GDU  A 802 (-3.1A)
None
 1.05A 3b2rA-3ukfA:
undetectable		 3b2rA-3ukfA:
20.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T01_A_PPFA503_1
(PHOSPHONOACETATE
HYDROLASE)		 3ukf UDP-GALACTOPYRANOSE
MUTASE
(Aspergillus
fumigatus) 		4 / 7 ASN A 207
ASP A 459
HIS A 460
HIS A  68
 GDU  A 802 (-3.3A)
None
None
None
 0.89A 3t01A-3ukfA:
undetectable		 3t01A-3ukfA:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3S_D_9PLD1_1
(CYTOCHROME P450 2A13)		 4rph UDP-GALACTOPYRANOSE
MUTASE
(Mycobacterium
tuberculosis) 		4 / 8 ALA B  93
PHE B 102
ASN B 284
ALA B 156
 None
GDU  B 402 (-3.9A)
GDU  B 402 (-3.6A)
None
 0.90A 3t3sD-4rphB:
undetectable		 3t3sD-4rphB:
22.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UZZ_B_ASDB501_1
(3-OXO-5-BETA-STEROID
4-DEHYDROGENASE)		 3ukf UDP-GALACTOPYRANOSE
MUTASE
(Aspergillus
fumigatus) 		4 / 8 TYR A 326
TYR A 453
MET A 174
TRP A 178
 None
GDU  A 802 (-4.8A)
None
None
 1.22A 3uzzB-3ukfA:
undetectable		 3uzzB-3ukfA:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WFA_B_EDTB802_0
(ALPHA-GLUCOSIDASE)		 3hdy UDP-GALACTOPYRANOSE
MUTASE
(Deinococcus
radiodurans) 		4 / 6 ARG A 198
ASP A 374
ASN A 372
TYR A 370
 GDU  A 500 (-3.8A)
None
FAD  A 450 ( 4.3A)
GDU  A 500 (-4.8A)
 1.28A 3wfaA-3hdyA:
undetectable
3wfaB-3hdyA:
undetectable		 3wfaA-3hdyA:
20.03
3wfaB-3hdyA:
20.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WFA_B_EDTB802_0
(ALPHA-GLUCOSIDASE)		 3ukf UDP-GALACTOPYRANOSE
MUTASE
(Aspergillus
fumigatus) 		4 / 6 ARG A 182
ASP A 459
ASN A 457
TYR A 453
 GDU  A 802 (-3.5A)
None
GDU  A 802 ( 4.0A)
GDU  A 802 (-4.8A)
 1.32A 3wfaA-3ukfA:
undetectable
3wfaB-3ukfA:
undetectable		 3wfaA-3ukfA:
22.57
3wfaB-3ukfA:
22.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P3Q_A_FOLA201_1
(DIHYDROFOLATE
REDUCTASE)		 3ukf UDP-GALACTOPYRANOSE
MUTASE
(Aspergillus
fumigatus) 		4 / 5 ASP A  59
ARG A 182
ARG A 447
THR A  49
 None
GDU  A 802 (-3.5A)
FDA  A 600 (-3.9A)
None
 1.40A 4p3qA-3ukfA:
undetectable		 4p3qA-3ukfA:
14.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XE5_A_OBNA1104_2
(SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1)		 3hdy UDP-GALACTOPYRANOSE
MUTASE
(Deinococcus
radiodurans) 		4 / 6 PRO A 298
ILE A 122
VAL A 163
THR A 180
 None
GDU  A 500 ( 4.3A)
None
GDU  A 500 (-3.2A)
 1.14A 4xe5A-3hdyA:
undetectable		 4xe5A-3hdyA:
16.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L8D_A_EDTA609_0
(NICKEL-BINDING
PERIPLASMIC PROTEIN)		 3ukf UDP-GALACTOPYRANOSE
MUTASE
(Aspergillus
fumigatus) 		4 / 8 TYR A 453
ARG A 182
TYR A 326
THR A 295
 GDU  A 802 (-4.8A)
GDU  A 802 (-3.5A)
None
FDA  A 600 ( 3.9A)
 1.42A 5l8dA-3ukfA:
undetectable		 5l8dA-3ukfA:
23.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MWU_A_EDTA609_0
(NICKEL-BINDING
PERIPLASMIC PROTEIN)		 3ukf UDP-GALACTOPYRANOSE
MUTASE
(Aspergillus
fumigatus) 		4 / 8 TYR A 453
ARG A 182
TYR A 326
THR A 295
 GDU  A 802 (-4.8A)
GDU  A 802 (-3.5A)
None
FDA  A 600 ( 3.9A)
 1.42A 5mwuA-3ukfA:
undetectable		 5mwuA-3ukfA:
23.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0O_A_SAMA501_0
(PEPTIDE
N-METHYLTRANSFERASE)		 4rph UDP-GALACTOPYRANOSE
MUTASE
(Mycobacterium
tuberculosis) 		5 / 12 ILE B 126
GLY B 150
PHE B 157
VAL B 158
ALA B 122
 None
None
None
GDU  B 402 (-3.2A)
None
 0.91A 5n0oA-4rphB:
undetectable		 5n0oA-4rphB:
24.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0O_B_SAMB501_0
(PEPTIDE
N-METHYLTRANSFERASE)		 4rph UDP-GALACTOPYRANOSE
MUTASE
(Mycobacterium
tuberculosis) 		5 / 12 ILE B 126
GLY B 150
PHE B 157
VAL B 158
ALA B 122
 None
None
None
GDU  B 402 (-3.2A)
None
 0.91A 5n0oB-4rphB:
undetectable		 5n0oB-4rphB:
24.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0R_A_SAMA501_0
(PEPTIDE
N-METHYLTRANSFERASE)		 4rph UDP-GALACTOPYRANOSE
MUTASE
(Mycobacterium
tuberculosis) 		5 / 12 ILE B 126
GLY B 150
PHE B 157
VAL B 158
ALA B 122
 None
None
None
GDU  B 402 (-3.2A)
None
 0.88A 5n0rA-4rphB:
undetectable		 5n0rA-4rphB:
24.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0S_A_SAMA501_0
(PEPTIDE
N-METHYLTRANSFERASE)		 4rph UDP-GALACTOPYRANOSE
MUTASE
(Mycobacterium
tuberculosis) 		5 / 12 ILE B 126
GLY B 150
PHE B 157
VAL B 158
ALA B 122
 None
None
None
GDU  B 402 (-3.2A)
None
 0.90A 5n0sA-4rphB:
undetectable		 5n0sA-4rphB:
24.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0T_A_SAMA501_0
(PEPTIDE
N-METHYLTRANSFERASE)		 4rph UDP-GALACTOPYRANOSE
MUTASE
(Mycobacterium
tuberculosis) 		5 / 12 ILE B 126
GLY B 150
PHE B 157
VAL B 158
ALA B 122
 None
None
None
GDU  B 402 (-3.2A)
None
 0.90A 5n0tA-4rphB:
undetectable		 5n0tA-4rphB:
25.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0T_B_SAMB501_0
(PEPTIDE
N-METHYLTRANSFERASE)		 4rph UDP-GALACTOPYRANOSE
MUTASE
(Mycobacterium
tuberculosis) 		5 / 12 ILE B 126
GLY B 150
PHE B 157
VAL B 158
ALA B 122
 None
None
None
GDU  B 402 (-3.2A)
None
 0.89A 5n0tB-4rphB:
undetectable		 5n0tB-4rphB:
25.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0W_A_SAMA501_0
(PEPTIDE
N-METHYLTRANSFERASE)		 4rph UDP-GALACTOPYRANOSE
MUTASE
(Mycobacterium
tuberculosis) 		5 / 12 ILE B 126
GLY B 150
PHE B 157
VAL B 158
ALA B 122
 None
None
None
GDU  B 402 (-3.2A)
None
 0.91A 5n0wA-4rphB:
undetectable		 5n0wA-4rphB:
24.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0X_A_SAMA501_0
(PEPTIDE
N-METHYLTRANSFERASE)		 4rph UDP-GALACTOPYRANOSE
MUTASE
(Mycobacterium
tuberculosis) 		5 / 12 ILE B 126
GLY B 150
PHE B 157
VAL B 158
ALA B 122
 None
None
None
GDU  B 402 (-3.2A)
None
 0.92A 5n0xA-4rphB:
undetectable		 5n0xA-4rphB:
24.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0X_B_SAMB501_0
(PEPTIDE
N-METHYLTRANSFERASE)		 4rph UDP-GALACTOPYRANOSE
MUTASE
(Mycobacterium
tuberculosis) 		5 / 12 ILE B 126
GLY B 150
PHE B 157
VAL B 158
ALA B 122
 None
None
None
GDU  B 402 (-3.2A)
None
 0.92A 5n0xB-4rphB:
undetectable		 5n0xB-4rphB:
24.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EP4_A_DMEA601_1
(CHOLINESTERASE)		 4rph UDP-GALACTOPYRANOSE
MUTASE
(Mycobacterium
tuberculosis) 		4 / 5 TYR B 161
GLU B 315
TYR B  87
HIS B 294
 GDU  B 402 (-3.7A)
FAD  B 401 ( 4.1A)
None
None
 1.24A 6ep4A-4rphB:
undetectable		 6ep4A-4rphB:
11.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EP4_A_DMEA601_1
(CHOLINESTERASE)		 4rph UDP-GALACTOPYRANOSE
MUTASE
(Mycobacterium
tuberculosis) 		4 / 5 TYR B 328
GLU B 315
TYR B  87
HIS B 294
 GDU  B 402 ( 4.6A)
FAD  B 401 ( 4.1A)
None
None
 1.35A 6ep4A-4rphB:
undetectable		 6ep4A-4rphB:
11.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HZP_A_FVTA501_0
(PEPTIDE ABC
TRANSPORTER PERMEASE)		 3ukf UDP-GALACTOPYRANOSE
MUTASE
(Aspergillus
fumigatus) 		4 / 8 TYR A  69
VAL A 487
ASN A 488
ASN A 457
 None
None
None
GDU  A 802 ( 4.0A)
 1.07A 6hzpA-3ukfA:
undetectable		 6hzpA-3ukfA:
19.71