SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'GDS'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
11GS_B_EAAB211_1
(GLUTATHIONE
S-TRANSFERASE)		 2wdu GLUTATHIONE
TRANSFERASE SIGMA
CLASS
(Fasciola
hepatica) 		4 / 7 TYR A  10
PHE A  11
GLY A  15
ARG A  16
 DMS  A1214 ( 4.3A)
GSH  A 301 (-4.4A)
DMS  A1214 (-3.0A)
GDS  A 300 ( 4.1A)
 0.80A 11gsB-2wduA:
24.4		 11gsB-2wduA:
29.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIA_A_SAMA293_0
(GLYCINE
N-METHYLTRANSFERASE)		 3m8u HEME-BINDING PROTEIN
A
(Glaesserella
parasuis) 		5 / 12 ILE A 414
GLY A 428
ALA A 499
GLY A 425
TYR A 413
 MLI  A   3 ( 3.9A)
GDS  A   1 (-3.6A)
None
None
None
 1.04A 1kiaA-3m8uA:
undetectable		 1kiaA-3m8uA:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIA_B_SAMB1293_0
(GLYCINE
N-METHYLTRANSFERASE)		 3m8u HEME-BINDING PROTEIN
A
(Glaesserella
parasuis) 		5 / 12 ILE A 414
GLY A 428
ALA A 499
GLY A 425
TYR A 413
 MLI  A   3 ( 3.9A)
GDS  A   1 (-3.6A)
None
None
None
 1.05A 1kiaB-3m8uA:
undetectable		 1kiaB-3m8uA:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIA_C_SAMC2293_0
(GLYCINE
N-METHYLTRANSFERASE)		 3m8u HEME-BINDING PROTEIN
A
(Glaesserella
parasuis) 		5 / 12 ILE A 414
GLY A 428
ALA A 499
GLY A 425
TYR A 413
 MLI  A   3 ( 3.9A)
GDS  A   1 (-3.6A)
None
None
None
 1.06A 1kiaC-3m8uA:
undetectable		 1kiaC-3m8uA:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NBH_B_SAMB1293_0
(GLYCINE
N-METHYLTRANSFERASE)		 3m8u HEME-BINDING PROTEIN
A
(Glaesserella
parasuis) 		5 / 12 ILE A 414
GLY A 428
ALA A 499
GLY A 425
TYR A 413
 MLI  A   3 ( 3.9A)
GDS  A   1 (-3.6A)
None
None
None
 1.04A 1nbhB-3m8uA:
undetectable		 1nbhB-3m8uA:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q9R_A_BEZA203_0
(PROTEIN OF UNKNOWN
FUNCTION)		 4zb8 PCURE2P6
(Phanerochaete
chrysosporium) 		4 / 5 GLY A  18
PRO A  59
ILE A  77
ILE A  78
 None
GDS  A 300 (-4.4A)
None
None
 0.84A 2q9rA-4zb8A:
undetectable		 2q9rA-4zb8A:
24.68
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2WB9_A_CYSA301_0
(GLUTATHIONE
TRANSFERASE SIGMA
CLASS)		 2wdu GLUTATHIONE
TRANSFERASE SIGMA
CLASS
(Fasciola
hepatica) 		5 / 5 TYR A  10
GLY A  15
ARG A  16
TYR A 106
TYR A 110
 DMS  A1214 ( 4.3A)
DMS  A1214 (-3.0A)
GDS  A 300 ( 4.1A)
None
GDS  A 300 (-4.6A)
 0.17A 2wb9A-2wduA:
36.4		 2wb9A-2wduA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BVA_A_T3A1314_1
(THIOMORPHOLINE-CARBO
XYLATE DEHYDROGENASE)		 4nax GLUTATHIONE
S-TRANSFERASE,
N-TERMINAL DOMAIN
PROTEIN
(Pseudomonas
putida) 		5 / 12 PHE A 139
GLY A 131
VAL A 133
HIS A 137
ARG A 195
 None
GDS  A 301 (-3.4A)
None
FMT  A 303 (-3.7A)
None
 1.45A 4bvaA-4naxA:
undetectable		 4bvaA-4naxA:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EJW_A_SRYA2001_1
(TRANSCRIPTIONAL
REGULATOR TCAR)		 3gx0 GST-LIKE PROTEIN
YFCG
(Escherichia
coli) 		5 / 12 ASN A  11
LEU A 112
GLN A 176
ALA A 172
TYR A 141
 GDS  A 301 (-2.9A)
None
None
None
None
 1.25A 4ejwA-3gx0A:
1.5		 4ejwA-3gx0A:
20.74
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4MF6_A_BEZA303_0
(GLUTATHIONE
S-TRANSFERASE DOMAIN)		 4nax GLUTATHIONE
S-TRANSFERASE,
N-TERMINAL DOMAIN
PROTEIN
(Pseudomonas
putida) 		5 / 5 THR A  28
PRO A  29
PHE A 139
ASN A 191
TYR A 196
 GDS  A 301 (-3.5A)
GDS  A 301 ( 4.5A)
None
None
None
 0.30A 4mf6A-4naxA:
36.9		 4mf6A-4naxA:
65.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKV_B_AERB601_1
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 4c0r PUTATIVE AMINO ACID
BINDING PROTEIN
(Streptococcus
mutans) 		5 / 12 LEU A 145
ILE A 170
ILE A 171
VAL A  94
VAL A 181
 GDS  A 500 ( 3.3A)
None
None
None
None
 0.93A 4nkvB-4c0rA:
undetectable		 4nkvB-4c0rA:
20.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKX_C_STRC601_1
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 4c0r PUTATIVE AMINO ACID
BINDING PROTEIN
(Streptococcus
mutans) 		5 / 12 LEU A 145
ILE A 170
ILE A 161
VAL A  94
VAL A 181
 GDS  A 500 ( 3.3A)
None
None
None
None
 0.89A 4nkxC-4c0rA:
undetectable		 4nkxC-4c0rA:
20.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKX_D_STRD601_1
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 4c0r PUTATIVE AMINO ACID
BINDING PROTEIN
(Streptococcus
mutans) 		5 / 12 LEU A 145
ILE A 170
ILE A 161
VAL A  94
VAL A 181
 GDS  A 500 ( 3.3A)
None
None
None
None
 0.87A 4nkxD-4c0rA:
undetectable		 4nkxD-4c0rA:
20.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WH5_A_3QBA204_1
(LINCOSAMIDE
RESISTANCE PROTEIN)		 4mzw GLUTATHIONE
S-TRANSFERASE
(Streptococcus
sanguinis) 		5 / 12 GLY A  82
ASP A  81
ILE A  79
GLN A  84
PHE A  19
 None
None
GDS  A 301 ( 3.8A)
GDS  A 301 (-4.0A)
GDS  A 301 (-3.6A)
 1.29A 4wh5A-4mzwA:
undetectable		 4wh5A-4mzwA:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZDZ_A_TPFA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 4mzw GLUTATHIONE
S-TRANSFERASE
(Streptococcus
sanguinis) 		4 / 7 ILE A  79
GLY A  52
THR A  56
LEU A  74
 GDS  A 301 ( 3.8A)
None
None
None
 0.81A 4zdzA-4mzwA:
undetectable		 4zdzA-4mzwA:
19.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGV_A_ZITA404_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)		 3m8u HEME-BINDING PROTEIN
A
(Glaesserella
parasuis) 		5 / 12 ILE A 288
GLY A 428
HIS A 500
ILE A 318
MET A 388
 None
GDS  A   1 (-3.6A)
None
None
None
 1.07A 5igvA-3m8uA:
undetectable		 5igvA-3m8uA:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGW_A_CTYA404_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)		 3m8u HEME-BINDING PROTEIN
A
(Glaesserella
parasuis) 		5 / 12 ILE A 288
GLY A 428
HIS A 500
ILE A 318
MET A 388
 None
GDS  A   1 (-3.6A)
None
None
None
 0.98A 5igwA-3m8uA:
undetectable		 5igwA-3m8uA:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KF8_A_GCSA404_1
(PREDICTED
ACETYLTRANSFERASE)		 4zb6 PCURE2P4
(Phanerochaete
chrysosporium) 		4 / 8 TRP A 176
PRO A  60
GLY A  16
PRO A  17
 GDS  A 300 (-4.0A)
GDS  A 300 (-4.5A)
GDS  A 300 (-3.7A)
NA  A 301 ( 4.6A)
 1.03A 5kf8A-4zb6A:
undetectable		 5kf8A-4zb6A:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KF8_A_GCSA404_1
(PREDICTED
ACETYLTRANSFERASE)		 4zb8 PCURE2P6
(Phanerochaete
chrysosporium) 		4 / 8 TRP A 175
PRO A  59
GLY A  15
PRO A  16
 GDS  A 300 (-4.0A)
GDS  A 300 (-4.4A)
GDS  A 300 (-3.6A)
GDS  A 300 (-4.2A)
 1.08A 5kf8A-4zb8A:
undetectable		 5kf8A-4zb8A:
19.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KGP_A_GCSA407_1
(PREDICTED
ACETYLTRANSFERASE)		 4zb6 PCURE2P4
(Phanerochaete
chrysosporium) 		4 / 8 TRP A 176
PRO A  60
GLY A  16
PRO A  17
 GDS  A 300 (-4.0A)
GDS  A 300 (-4.5A)
GDS  A 300 (-3.7A)
NA  A 301 ( 4.6A)
 1.06A 5kgpA-4zb6A:
undetectable		 5kgpA-4zb6A:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KGP_A_GCSA407_1
(PREDICTED
ACETYLTRANSFERASE)		 4zb8 PCURE2P6
(Phanerochaete
chrysosporium) 		4 / 8 TRP A 175
PRO A  59
GLY A  15
PRO A  16
 GDS  A 300 (-4.0A)
GDS  A 300 (-4.4A)
GDS  A 300 (-3.6A)
GDS  A 300 (-4.2A)
 1.12A 5kgpA-4zb8A:
undetectable		 5kgpA-4zb8A:
19.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KGP_B_GCSB405_1
(PREDICTED
ACETYLTRANSFERASE)		 4zb6 PCURE2P4
(Phanerochaete
chrysosporium) 		4 / 8 TRP A 176
PRO A  60
GLY A  16
PRO A  17
 GDS  A 300 (-4.0A)
GDS  A 300 (-4.5A)
GDS  A 300 (-3.7A)
NA  A 301 ( 4.6A)
 1.06A 5kgpB-4zb6A:
undetectable		 5kgpB-4zb6A:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KGP_B_GCSB405_1
(PREDICTED
ACETYLTRANSFERASE)		 4zb8 PCURE2P6
(Phanerochaete
chrysosporium) 		4 / 8 TRP A 175
PRO A  59
GLY A  15
PRO A  16
 GDS  A 300 (-4.0A)
GDS  A 300 (-4.4A)
GDS  A 300 (-3.6A)
GDS  A 300 (-4.2A)
 1.12A 5kgpB-4zb8A:
undetectable		 5kgpB-4zb8A:
19.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KMD_C_6UBC1304_1
(ION TRANSPORT
PROTEIN)		 4mzw GLUTATHIONE
S-TRANSFERASE
(Streptococcus
sanguinis) 		4 / 5 TYR A 164
LEU A 154
GLY A 155
PHE A 158
 None
None
GDS  A 301 (-3.3A)
None
 0.93A 5kmdC-4mzwA:
2.3
5kmdD-4mzwA:
2.6		 5kmdC-4mzwA:
22.91
5kmdD-4mzwA:
22.91
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5UUN_B_ACTB308_0
(GLUTATHIONE
S-TRANSFERASE-LIKE
PROTEIN)		 4mzw GLUTATHIONE
S-TRANSFERASE
(Streptococcus
sanguinis) 		3 / 3 LEU A  47
ILE A  79
TYR A 164
 None
GDS  A 301 ( 3.8A)
None
 0.30A 5uunB-4mzwA:
36.0		 5uunB-4mzwA:
48.04
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5UUN_B_ACTB311_0
(GLUTATHIONE
S-TRANSFERASE-LIKE
PROTEIN)		 4mzw GLUTATHIONE
S-TRANSFERASE
(Streptococcus
sanguinis) 		4 / 4 PHE A  19
PRO A  50
TYR A 164
TYR A 222
 GDS  A 301 (-3.6A)
None
None
None
 0.28A 5uunB-4mzwA:
36.0		 5uunB-4mzwA:
48.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EXI_B_ADNB503_0
(ADENOSYLHOMOCYSTEINA
SE)		 4c0r PUTATIVE AMINO ACID
BINDING PROTEIN
(Streptococcus
mutans) 		3 / 3 LEU A 138
GLN A 125
LYS A 160
 None
None
GDS  A 500 (-2.7A)
 1.00A 6exiA-4c0rA:
undetectable		 6exiA-4c0rA:
15.98