SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'GDR'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1FAP_A_RAPA108_2 (FK506-BINDING PROTEIN FRAP)	1n7g	GDP-D-MANNOSE-4,6-DE HYDRATASE (Arabidopsis thaliana)	4 / 8	LEU A 212 SER A 163 PHE A 166 GLY A 167	NDP A 701 (-4.9A) GDR A 801 (-3.5A) None None	0.72A	1fapB-1n7gA: undetectable	1fapB-1n7gA: 13.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1MRQ_A_STRA501_1 (ALDO-KETO REDUCTASE FAMILY 1 MEMBER C1)	1n7g	GDP-D-MANNOSE-4,6-DE HYDRATASE (Arabidopsis thaliana)	5 / 11	LEU A 321 GLU A 317 VAL A 318 GLU A 216 TRP A 255	None GDR A 801 (-2.9A) None NDP A 701 ( 4.8A) None	1.22A	1mrqA-1n7gA: 2.1	1mrqA-1n7gA: 23.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2Y00_B_Y00B601_2 (BETA-1 ADRENERGIC RECEPTOR)	1n7g	GDP-D-MANNOSE-4,6-DE HYDRATASE (Arabidopsis thaliana)	3 / 3	VAL A 119 ASN A 214 TRP A 255	GDR A 801 (-4.3A) GDR A 801 ( 3.1A) None	1.11A	2y00B-1n7gA: undetectable	2y00B-1n7gA: 22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2Y05_A_RALA802_1 (PROSTAGLANDIN REDUCTASE 1)	1n7g	GDP-D-MANNOSE-4,6-DE HYDRATASE (Arabidopsis thaliana)	4 / 7	ASN A 248 GLY A 247 VAL A 225 ASP A 309	None GDR A 801 (-3.6A) GDR A 801 (-3.6A) None	0.89A	2y05A-1n7gA: 5.0 2y05B-1n7gA: 5.5	2y05A-1n7gA: 22.28 2y05B-1n7gA: 22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4DRI_A_RAPA201_2 (PEPTIDYL-PROLYL CIS-TRANS ISOMERASE FKBP5 SERINE/THREONINE-PRO TEIN KINASE MTOR)	1n7g	GDP-D-MANNOSE-4,6-DE HYDRATASE (Arabidopsis thaliana)	5 / 10	LEU A 212 SER A 163 ARG A 253 PHE A 166 ASP A 276	NDP A 701 (-4.9A) GDR A 801 (-3.5A) GDR A 801 (-3.4A) None None	1.46A	4driB-1n7gA: 0.0	4driB-1n7gA: 13.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4DRJ_A_RAPA201_2 (PEPTIDYL-PROLYL CIS-TRANS ISOMERASE FKBP4 SERINE/THREONINE-PRO TEIN KINASE MTOR)	1n7g	GDP-D-MANNOSE-4,6-DE HYDRATASE (Arabidopsis thaliana)	4 / 8	LEU A 212 SER A 163 PHE A 166 THR A 176	NDP A 701 (-4.9A) GDR A 801 (-3.5A) None None	0.95A	4drjB-1n7gA: undetectable	4drjB-1n7gA: 13.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6BPL_B_PA1B605_1 (LIPID A EXPORT ATP-BINDING/PERMEASE PROTEIN MSBA)	1n7g	GDP-D-MANNOSE-4,6-DE HYDRATASE (Arabidopsis thaliana)	3 / 3	ARG A 314 ARG A 220 ARG A 253	GDR A 801 (-3.3A) GDR A 801 ( 2.6A) GDR A 801 (-3.4A)	1.04A	6bplA-1n7gA: undetectable 6bplB-1n7gA: undetectable	6bplA-1n7gA: 12.00 6bplB-1n7gA: 12.00

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["1FAP_A_RAPA108_2","FK506-BINDING PROTEIN;FRAP","1n7g","GDP-D-MANNOSE-4,6-DEHYDRATASE","Arabidopsis thaliana",4,"LEU A 212;SER A 163;PHE A 166;GLY A 167","NDP A 701 (-4.9A);GDR A 801 (-3.5A);None;None","0.72A","1fapB-1n7gA:undetectable",null],["1MRQ_A_STRA501_1","ALDO-KETO REDUCTASE FAMILY 1 MEMBER C1","1n7g","GDP-D-MANNOSE-4,6-DEHYDRATASE","Arabidopsis thaliana",5,"LEU A 321;GLU A 317;VAL A 318;GLU A 216;TRP A 255","None;GDR A 801 (-2.9A);None;NDP A 701 ( 4.8A);None","1.22A","1mrqA-1n7gA:2.1","1fapB-1n7gA:13.14"],["2Y00_B_Y00B601_2","BETA-1 ADRENERGIC RECEPTOR","1n7g","GDP-D-MANNOSE-4,6-DEHYDRATASE","Arabidopsis thaliana",3,"VAL A 119;ASN A 214;TRP A 255","GDR A 801 (-4.3A);GDR A 801 ( 3.1A);None","1.11A","2y00B-1n7gA:undetectable","1mrqA-1n7gA:23.10"],["2Y05_A_RALA802_1","PROSTAGLANDIN REDUCTASE 1;PROSTAGLANDIN REDUCTASE 1","1n7g","GDP-D-MANNOSE-4,6-DEHYDRATASE","Arabidopsis thaliana",4,"ASN A 248;GLY A 247;VAL A 225;ASP A 309","None;GDR A 801 (-3.6A);GDR A 801 (-3.6A);None","0.89A","2y05A-1n7gA:5.0;2y05B-1n7gA:5.5","2y00B-1n7gA:22.28"],["4DRI_A_RAPA201_2","PEPTIDYL-PROLYL CIS-TRANS ISOMERASE FKBP5;SERINE\/THREONINE-PROTEIN KINASE MTOR","1n7g","GDP-D-MANNOSE-4,6-DEHYDRATASE","Arabidopsis thaliana",5,"LEU A 212;SER A 163;ARG A 253;PHE A 166;ASP A 276","NDP A 701 (-4.9A);GDR A 801 (-3.5A);GDR A 801 (-3.4A);None;None","1.46A","4driB-1n7gA:0.0","2y05A-1n7gA:22.28;2y05B-1n7gA:22.28"],["4DRJ_A_RAPA201_2","PEPTIDYL-PROLYL CIS-TRANS ISOMERASE FKBP4;SERINE\/THREONINE-PROTEIN KINASE MTOR","1n7g","GDP-D-MANNOSE-4,6-DEHYDRATASE","Arabidopsis thaliana",4,"LEU A 212;SER A 163;PHE A 166;THR A 176","NDP A 701 (-4.9A);GDR A 801 (-3.5A);None;None","0.95A","4drjB-1n7gA:undetectable","4driB-1n7gA:13.21"],["6BPL_B_PA1B605_1","LIPID A EXPORT ATP-BINDING\/PERMEASE PROTEIN MSBA;LIPID A EXPORT ATP-BINDING\/PERMEASE PROTEIN MSBA","1n7g","GDP-D-MANNOSE-4,6-DEHYDRATASE","Arabidopsis thaliana",3,"ARG A 314;ARG A 220;ARG A 253","GDR A 801 (-3.3A);GDR A 801 ( 2.6A);GDR A 801 (-3.4A)","1.04A","6bplA-1n7gA:undetectable;6bplB-1n7gA:undetectable","4drjB-1n7gA:13.21"]]