SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'GDP'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AQ7_B_AG2B4_1
(TRYPSIN
AERUGINOSIN 98-B)		 3cx6 GUANINE
NUCLEOTIDE-BINDING
PROTEIN ALPHA-13
SUBUNIT
(Mus
musculus) 		4 / 8 SER A  59
SER A  62
GLY A 225
GLY A  55
 GDP  A 775 (-3.4A)
MG  A 675 ( 2.7A)
None
None
 0.70A 1aq7A-3cx6A:
undetectable		 1aq7A-3cx6A:
20.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AQ7_B_AG2B4_1
(TRYPSIN
AERUGINOSIN 98-B)		 3cx6 GUANINE
NUCLEOTIDE-BINDING
PROTEIN ALPHA-13
SUBUNIT
(Mus
musculus) 		5 / 8 SER A 268
SER A 248
VAL A 247
GLY A  57
GLY A  55
 None
None
None
GDP  A 775 ( 4.2A)
None
 1.24A 1aq7A-3cx6A:
undetectable		 1aq7A-3cx6A:
20.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1BU5_A_RBFA301_1
(PROTEIN (FLAVODOXIN))		 1ofu CELL DIVISION
PROTEIN FTSZ
(Pseudomonas
aeruginosa) 		4 / 7 THR A 109
ASN A  44
THR A 102
GLY A  24
 GDP  A1318 (-4.1A)
GDP  A1318 ( 4.7A)
None
None
 0.98A 1bu5A-1ofuA:
5.6		 1bu5A-1ofuA:
17.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1BX4_A_ADNA355_1
(PROTEIN (ADENOSINE
KINASE))		 1ofu CELL DIVISION
PROTEIN FTSZ
(Pseudomonas
aeruginosa) 		6 / 12 GLY A  18
ILE A  89
ALA A 113
GLY A 110
ALA A 114
ILE A 117
 None
None
None
GDP  A1318 (-3.5A)
None
None
 1.47A 1bx4A-1ofuA:
8.3		 1bx4A-1ofuA:
19.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1BX4_A_ADNA355_1
(PROTEIN (ADENOSINE
KINASE))		 2r6r CELL DIVISION
PROTEIN FTSZ
(Aquifex
aeolicus) 		6 / 12 GLY 1  14
ILE 1  85
ALA 1 109
GLY 1 106
ALA 1 110
ILE 1 113
 None
None
None
GDP  1 339 (-3.5A)
None
None
 1.44A 1bx4A-2r6r1:
6.2		 1bx4A-2r6r1:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CMA_B_SAMB105_0
(PROTEIN (MET
REPRESSOR))		 2y4l MANNOSYLGLYCERATE
SYNTHASE
(Rhodothermus
marinus) 		5 / 11 GLU A  90
GLU A  31
LEU A  33
ALA A  83
GLY A  79
 None
None
None
None
GDP  A 401 ( 3.8A)
 1.32A 1cmaA-2y4lA:
undetectable
1cmaB-2y4lA:
undetectable		 1cmaA-2y4lA:
13.06
1cmaB-2y4lA:
13.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DSC_C_DVAC2_0
(ACTINOMYCIN D)		 2r6r CELL DIVISION
PROTEIN FTSZ
(Aquifex
aeolicus) 		3 / 3 THR 1 105
PRO 1  71
THR 1 107
 GDP  1 339 (-4.3A)
None
None
 0.93A 1dscC-2r6r1:
undetectable		 1dscC-2r6r1:
4.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E7A_A_PFLA4002_1
(SERUM ALBUMIN)		 1wms RAS-RELATED PROTEIN
RAB-9A
(Homo
sapiens) 		3 / 3 PHE A  32
LEU A  23
SER A 154
 GDP  A1001 (-4.3A)
None
GDP  A1001 (-3.3A)
 0.73A 1e7aA-1wmsA:
1.4		 1e7aA-1wmsA:
16.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E7A_A_PFLA4002_1
(SERUM ALBUMIN)		 2erx GTP-BINDING PROTEIN
DI-RAS2
(Homo
sapiens) 		3 / 3 PHE A  32
LEU A  23
SER A 151
 GDP  A 401 (-4.3A)
None
GDP  A 401 (-3.2A)
 0.71A 1e7aA-2erxA:
undetectable		 1e7aA-2erxA:
15.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E7A_A_PFLA4002_1
(SERUM ALBUMIN)		 2ery RAS-RELATED PROTEIN
R-RAS2
(Homo
sapiens) 		3 / 3 PHE A  39
LEU A  30
SER A 157
 GDP  A   1 (-4.1A)
None
GDP  A   1 (-3.3A)
 0.71A 1e7aA-2eryA:
undetectable		 1e7aA-2eryA:
13.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E7A_A_PFLA4002_1
(SERUM ALBUMIN)		 2fn4 RAS-RELATED PROTEIN
R-RAS
(Homo
sapiens) 		3 / 3 PHE A  54
LEU A  45
SER A 172
 GDP  A   1 ( 4.9A)
None
GDP  A   1 (-3.5A)
 0.75A 1e7aA-2fn4A:
1.3		 1e7aA-2fn4A:
14.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E7A_A_PFLA4002_1
(SERUM ALBUMIN)		 3cph RAS-RELATED PROTEIN
SEC4
(Saccharomyces
cerevisiae) 		3 / 3 PHE A  45
LEU A  36
SER A 162
 GDP  A 302 (-4.4A)
None
GDP  A 302 (-3.2A)
 0.70A 1e7aA-3cphA:
undetectable		 1e7aA-3cphA:
13.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E7A_A_PFLA4002_1
(SERUM ALBUMIN)		 3cpj GTP-BINDING PROTEIN
YPT31/YPT8
(Saccharomyces
cerevisiae) 		3 / 3 PHE B  38
LEU B  29
SER B 156
 GDP  B1207 (-4.5A)
None
GDP  B1207 (-3.6A)
 0.83A 1e7aA-3cpjB:
undetectable		 1e7aA-3cpjB:
17.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E7A_A_PFLA4002_1
(SERUM ALBUMIN)		 4m8n RAS-RELATED PROTEIN
RAP-1B
(Homo
sapiens) 		3 / 3 PHE E  28
LEU E  19
SER E 147
 GDP  E 201 (-4.7A)
None
GDP  E 201 (-3.7A)
 0.79A 1e7aA-4m8nE:
undetectable		 1e7aA-4m8nE:
15.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E7A_A_PFLA4002_1
(SERUM ALBUMIN)		 4z8y RAS-RELATED PROTEIN
SEC4
(Saccharomyces
cerevisiae) 		3 / 3 PHE A  45
LEU A  36
SER A 162
 GDP  A 201 (-4.4A)
None
GDP  A 201 (-3.4A)
 0.70A 1e7aA-4z8yA:
undetectable		 1e7aA-4z8yA:
12.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E7B_A_HLTA4003_1
(SERUM ALBUMIN)		 1fzq ADP-RIBOSYLATION
FACTOR-LIKE PROTEIN
3
(Mus
musculus) 		5 / 9 LEU A 122
VAL A 166
GLY A 165
ALA A 160
LEU A  33
 None
None
None
GDP  A 301 (-3.7A)
None
 0.93A 1e7bA-1fzqA:
undetectable		 1e7bA-1fzqA:
15.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E7B_A_HLTA4003_1
(SERUM ALBUMIN)		 1xje RIBONUCLEOTIDE
REDUCTASE,
B12-DEPENDENT
(Thermotoga
maritima) 		5 / 9 ASN A 593
LEU A 327
GLY A 323
ALA A 489
LEU A 335
 None
None
None
GDP  A1002 (-3.4A)
None
 1.15A 1e7bA-1xjeA:
undetectable		 1e7bA-1xjeA:
22.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EE2_A_CHDA1150_0
(ALCOHOL
DEHYDROGENASE)		 3gp9 NUCLEOSIDE
DIPHOSPHATE KINASE
(Acanthamoeba
polyphaga
mimivirus) 		5 / 11 SER A 114
HIS A 112
SER A  73
LEU A   7
ILE A 126
 None
GDP  A 138 ( 3.5A)
None
None
None
 1.17A 1ee2A-3gp9A:
undetectable		 1ee2A-3gp9A:
16.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EIZ_A_SAMA301_0
(FTSJ)		 4b46 CELL DIVISION
PROTEIN FTSZ
(Haloferax
volcanii) 		5 / 12 GLY A 106
PRO A 117
GLY A 115
GLY A 114
LEU A 134
 GDP  A1368 (-3.6A)
None
None
None
None
 0.99A 1eizA-4b46A:
4.6		 1eizA-4b46A:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EJ0_A_SAMA301_0
(FTSJ)		 4b46 CELL DIVISION
PROTEIN FTSZ
(Haloferax
volcanii) 		5 / 12 GLY A 106
PRO A 117
GLY A 115
GLY A 114
LEU A 134
 GDP  A1368 (-3.6A)
None
None
None
None
 1.00A 1ej0A-4b46A:
undetectable		 1ej0A-4b46A:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1F5L_A_AMRA301_1
(UROKINASE-TYPE
PLASMINOGEN
ACTIVATOR)		 1zca G ALPHA I/12
(Mus
musculus) 		4 / 8 SER A  66
SER A  69
GLY A 228
GLY A  62
 GDP  A 382 (-2.9A)
MG  A 383 ( 2.1A)
ALF  A 384 (-3.3A)
None
 0.65A 1f5lA-1zcaA:
undetectable		 1f5lA-1zcaA:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1F5L_A_AMRA301_1
(UROKINASE-TYPE
PLASMINOGEN
ACTIVATOR)		 2ik8 GUANINE
NUCLEOTIDE-BINDING
PROTEIN G(I),
ALPHA-1 SUBUNIT
(Homo
sapiens) 		4 / 8 SER A  44
SER A  47
GLY A 203
GLY A  40
 GDP  A 401 (-3.6A)
MG  A 356 ( 1.9A)
ALF  A 355 (-3.3A)
None
 0.72A 1f5lA-2ik8A:
undetectable		 1f5lA-2ik8A:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1F5L_A_AMRA301_1
(UROKINASE-TYPE
PLASMINOGEN
ACTIVATOR)		 3cx6 GUANINE
NUCLEOTIDE-BINDING
PROTEIN ALPHA-13
SUBUNIT
(Mus
musculus) 		4 / 8 SER A  59
SER A  62
GLY A 225
GLY A  55
 GDP  A 775 (-3.4A)
MG  A 675 ( 2.7A)
None
None
 0.67A 1f5lA-3cx6A:
undetectable		 1f5lA-3cx6A:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1F5L_A_AMRA301_1
(UROKINASE-TYPE
PLASMINOGEN
ACTIVATOR)		 5yew MITOFUSIN-1,MITOFUSI
N-1 FUSION PROTEIN
(Homo
sapiens) 		4 / 8 SER B  86
SER B  89
GLY B 181
GLY B  82
 GDP  B 801 (-4.1A)
MG  B 804 ( 2.1A)
BEF  B 802 (-3.3A)
None
 0.73A 1f5lA-5yewB:
undetectable		 1f5lA-5yewB:
17.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1F5L_A_AMRA301_1
(UROKINASE-TYPE
PLASMINOGEN
ACTIVATOR)		 6au6 GUANINE
NUCLEOTIDE-BINDING
PROTEIN G(S) SUBUNIT
ALPHA ISOFORMS SHORT
(Homo
sapiens) 		4 / 8 SER A  51
SER A  54
GLY A 226
GLY A  47
 GDP  A 401 (-3.4A)
MG  A 402 ( 2.1A)
None
None
 0.64A 1f5lA-6au6A:
undetectable		 1f5lA-6au6A:
15.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FDS_A_ESTA350_1
(17-BETA-HYDROXYSTERO
ID-DEHYDROGENASE)		 3md0 ARGININE/ORNITHINE
TRANSPORT SYSTEM
ATPASE
(Mycobacterium
tuberculosis) 		5 / 12 VAL A 176
LEU A 178
GLY A  62
SER A  72
MET A 242
 None
None
None
GDP  A 335 (-3.1A)
None
 1.09A 1fdsA-3md0A:
4.8		 1fdsA-3md0A:
26.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FDS_A_ESTA350_1
(17-BETA-HYDROXYSTERO
ID-DEHYDROGENASE)		 3nxs LAO/AO TRANSPORT
SYSTEM ATPASE
(Mycolicibacteriu
m
smegmatis) 		5 / 12 VAL A 172
LEU A 174
GLY A  58
SER A  68
MET A 238
 None
None
None
GDP  A 327 (-2.7A)
None
 1.18A 1fdsA-3nxsA:
4.8		 1fdsA-3nxsA:
26.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FDS_A_ESTA350_1
(17-BETA-HYDROXYSTERO
ID-DEHYDROGENASE)		 3tk1 MEMBRANE
ATPASE/PROTEIN
KINASE
(Mycolicibacteriu
m
thermoresistibil
e) 		5 / 12 VAL A 170
LEU A 172
GLY A  56
SER A  66
MET A 236
 None
None
None
GDP  A 327 (-4.0A)
None
 1.24A 1fdsA-3tk1A:
3.9		 1fdsA-3tk1A:
24.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FDU_C_ESTC353_1
(17-BETA-HYDROXYSTERO
ID DEHYDROGENASE)		 3md0 ARGININE/ORNITHINE
TRANSPORT SYSTEM
ATPASE
(Mycobacterium
tuberculosis) 		5 / 12 VAL A 176
LEU A 178
GLY A  62
SER A  72
MET A 242
 None
None
None
GDP  A 335 (-3.1A)
None
 1.19A 1fduC-3md0A:
3.8		 1fduC-3md0A:
25.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FJA_C_DVAC8_0
(ACTINOMYCIN D)		 2vaw CELL DIVISION
PROTEIN FTSZ
(Pseudomonas
aeruginosa) 		3 / 3 THR A 111
THR A 109
PRO A  75
 None
GDP  A1317 (-4.0A)
None
 0.87A 1fjaC-2vawA:
undetectable		 1fjaC-2vawA:
4.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FJA_D_DVAD8_0
(ACTINOMYCIN D)		 2vaw CELL DIVISION
PROTEIN FTSZ
(Pseudomonas
aeruginosa) 		3 / 3 THR A 111
THR A 109
PRO A  75
 None
GDP  A1317 (-4.0A)
None
 0.87A 1fjaD-2vawA:
undetectable		 1fjaD-2vawA:
4.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FK6_A_LNLA1201_1
(NON-SPECIFIC LIPID
TRANSFER PROTEIN)		 2lkd TRANSLATION
INITIATION FACTOR
IF-2
(Geobacillus
stearothermophil
us) 		5 / 12 LEU A  24
ALA A  27
ALA A 152
LEU A 150
ILE A 111
 None
None
GDP  A 179 (-3.1A)
None
None
 1.01A 1fk6A-2lkdA:
undetectable		 1fk6A-2lkdA:
18.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GSF_C_EAAC223_1
(GLUTATHIONE
TRANSFERASE A1-1)		 4b8w GDP-L-FUCOSE
SYNTHASE
(Homo
sapiens) 		4 / 8 PHE A 280
GLY A 278
LEU A  76
VAL A 187
 None
None
GDP  A 901 (-3.8A)
GDP  A 901 (-3.6A)
 1.03A 1gsfC-4b8wA:
undetectable		 1gsfC-4b8wA:
20.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTI_E_CCSE47_0
(GLUTATHIONE
S-TRANSFERASE)		 2w6d DYNAMIN FAMILY
PROTEIN
(Nostoc
punctiforme) 		4 / 7 THR A  84
LEU A  94
GLY A  91
LEU A 300
 GDP  A1696 (-3.8A)
None
None
None
 1.03A 1gtiE-2w6dA:
undetectable		 1gtiE-2w6dA:
16.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GXS_A_BEZA601_0
(P-(S)-HYDROXYMANDELO
NITRILE LYASE CHAIN
A
P-(S)-HYDROXYMANDELO
NITRILE LYASE CHAIN
B)		 5foe GDP-FUCOSE PROTEIN
O-FUCOSYLTRANSFERASE
2,THROMBOSPONDIN-1
(Caenorhabditis
elegans;
Homo
sapiens) 		4 / 7 GLY A 378
ASP A 329
SER A 379
ALA A 330
 None
GDP  A1428 (-3.8A)
None
None
 0.99A 1gxsA-5foeA:
undetectable
1gxsB-5foeA:
undetectable		 1gxsA-5foeA:
18.67
1gxsB-5foeA:
14.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HK1_A_T44A3004_1
(SERUM ALBUMIN)		 3q5e ATLASTIN-1
(Homo
sapiens) 		4 / 6 PHE A 293
PHE A  82
LEU A 286
VAL A 100
 None
GDP  A3850 (-4.2A)
None
None
 0.78A 1hk1A-3q5eA:
4.0		 1hk1A-3q5eA:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HK1_A_T44A3004_1
(SERUM ALBUMIN)		 6b9g ATLASTIN-1
(Homo
sapiens) 		4 / 6 PHE B 293
PHE B  82
LEU B 286
VAL B 100
 None
GDP  B 401 (-4.3A)
None
None
 0.61A 1hk1A-6b9gB:
undetectable		 1hk1A-6b9gB:
11.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HK3_A_T44A3001_1
(SERUM ALBUMIN)		 2dyk GTP-BINDING PROTEIN
(Thermus
thermophilus) 		5 / 11 LYS A 117
LEU A  93
ARG A   9
LEU A 130
ALA A  86
 GDP  A 501 (-3.6A)
None
None
None
None
 1.32A 1hk3A-2dykA:
undetectable		 1hk3A-2dykA:
14.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HK3_A_T44A3004_1
(SERUM ALBUMIN)		 6b9g ATLASTIN-1
(Homo
sapiens) 		4 / 7 PHE B 293
PHE B  82
LEU B 286
VAL B 100
 None
GDP  B 401 (-4.3A)
None
None
 0.57A 1hk3A-6b9gB:
undetectable		 1hk3A-6b9gB:
11.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I2W_A_CFXA1300_2
(BETA-LACTAMASE)		 4pde PROTEIN FDHD
(Escherichia
coli) 		4 / 5 TYR A 269
PRO A 272
LEU A 275
ARG A 265
 None
None
None
GDP  A 300 (-3.0A)
 1.14A 1i2wA-4pdeA:
undetectable		 1i2wA-4pdeA:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I3W_E_DVAE2_0
(ACTINOMYCIN D)		 1ofu CELL DIVISION
PROTEIN FTSZ
(Pseudomonas
aeruginosa) 		3 / 3 THR A 133
PRO A 165
THR A 163
 GDP  A1318 ( 4.9A)
None
None
 0.87A 1i3wE-1ofuA:
undetectable		 1i3wE-1ofuA:
6.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IG3_B_VIBB501_1
(THIAMIN
PYROPHOSPHOKINASE)		 2ik8 GUANINE
NUCLEOTIDE-BINDING
PROTEIN G(I),
ALPHA-1 SUBUNIT
(Homo
sapiens) 		4 / 7 GLN A 172
ASP A 173
LEU A 159
SER A 151
 None
None
None
GDP  A 401 (-3.6A)
 0.95A 1ig3A-2ik8A:
undetectable
1ig3B-2ik8A:
2.8		 1ig3A-2ik8A:
20.72
1ig3B-2ik8A:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IG3_B_VIBB501_1
(THIAMIN
PYROPHOSPHOKINASE)		 3c7k GUANINE
NUCLEOTIDE-BINDING
PROTEIN G(O) SUBUNIT
ALPHA
(Mus
musculus) 		4 / 7 GLN A 173
ASP A 174
LEU A 160
SER A 152
 None
None
None
GDP  A 361 (-3.2A)
 0.92A 1ig3A-3c7kA:
undetectable
1ig3B-3c7kA:
2.3		 1ig3A-3c7kA:
21.70
1ig3B-3c7kA:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1J8U_A_H4BA429_1
(PHENYLALANINE-4-HYDR
OXYLASE)		 5dn8 GTPASE DER
(Coxiella
burnetii) 		4 / 7 VAL A 334
LEU A 191
SER A 189
ALA A 237
 None
None
GDP  A 501 (-4.5A)
None
 0.86A 1j8uA-5dn8A:
undetectable		 1j8uA-5dn8A:
20.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JG2_A_ADNA500_1
(PROTEIN-L-ISOASPARTA
TE
O-METHYLTRANSFERASE)		 4b46 CELL DIVISION
PROTEIN FTSZ
(Haloferax
volcanii) 		5 / 12 GLY A 112
GLY A 106
LEU A 107
GLY A  75
VAL A 103
 GDP  A1368 (-3.5A)
GDP  A1368 (-3.6A)
None
None
None
 1.19A 1jg2A-4b46A:
undetectable		 1jg2A-4b46A:
20.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JG4_A_SAMA500_1
(PROTEIN-L-ISOASPARTA
TE
O-METHYLTRANSFERASE)		 3wgk CELL DIVISION
PROTEIN FTSZ
(Staphylococcus
aureus) 		4 / 8 SER A 103
ARG A  29
LEU A 190
ASP A  32
 None
None
GDP  A 400 (-4.9A)
None
 0.86A 1jg4A-3wgkA:
2.4		 1jg4A-3wgkA:
19.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JHO_A_NIOA991_1
(NICOTINATE
MONONUCLEOTIDE:5,6-D
IMETHYLBENZIMIDAZOLE
PHOSPHORIBOSYLTRANSF
ERASE)		 5ub8 LIKELY RAB FAMILY
GTP-BINDING PROTEIN
(Candida
albicans) 		5 / 9 THR A  71
GLY A  73
GLY A  27
GLU A  75
ARG A  76
 None
ZN  A 302 ( 4.7A)
GDP  A 301 (-3.1A)
GDP  A 301 ( 4.8A)
None
 1.22A 1jhoA-5ub8A:
undetectable		 1jhoA-5ub8A:
19.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JHR_A_NIOA991_1
(NICOTINATE
MONONUCLEOTIDE:5,6-D
IMETHYLBENZIMIDAZOLE
PHOSPHORIBOSYLTRANSF
ERASE)		 5ub8 LIKELY RAB FAMILY
GTP-BINDING PROTEIN
(Candida
albicans) 		5 / 9 THR A  71
GLY A  73
GLY A  27
GLU A  75
ARG A  76
 None
ZN  A 302 ( 4.7A)
GDP  A 301 (-3.1A)
GDP  A 301 ( 4.8A)
None
 1.23A 1jhrA-5ub8A:
undetectable		 1jhrA-5ub8A:
19.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1K6C_B_MK1B902_2
(POL POLYPROTEIN)		 1ofu CELL DIVISION
PROTEIN FTSZ
(Pseudomonas
aeruginosa) 		5 / 12 GLY A 192
ALA A 193
GLY A 227
PRO A 165
THR A 133
 None
None
None
None
GDP  A1318 ( 4.9A)
 0.94A 1k6cB-1ofuA:
undetectable		 1k6cB-1ofuA:
15.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIA_C_SAMC2293_0
(GLYCINE
N-METHYLTRANSFERASE)		 5yew MITOFUSIN-1,MITOFUSI
N-1 FUSION PROTEIN
(Homo
sapiens) 		5 / 12 ILE B 108
GLY B 181
ASP B 178
GLY B  87
LEU B 212
 K  B 803 (-4.2A)
BEF  B 802 (-3.3A)
MG  B 804 ( 3.8A)
GDP  B 801 (-3.6A)
None
 1.08A 1kiaC-5yewB:
undetectable		 1kiaC-5yewB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1L5K_A_NIOA991_1
(NICOTINATE-NUCLEOTID
E--DIMETHYLBENZIMIDA
ZOLE
PHOSPHORIBOSYLTRANSF
ERASE)		 5ub8 LIKELY RAB FAMILY
GTP-BINDING PROTEIN
(Candida
albicans) 		5 / 9 THR A  71
GLY A  73
GLY A  27
GLU A  75
ARG A  76
 None
ZN  A 302 ( 4.7A)
GDP  A 301 (-3.1A)
GDP  A 301 ( 4.8A)
None
 1.24A 1l5kA-5ub8A:
undetectable		 1l5kA-5ub8A:
19.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1L5L_A_NIOA991_1
(NICOTINATE-NUCLEOTID
E--DIMETHYLBENZIMIDA
ZOLE
PHOSPHORIBOSYLTRANSF
ERASE)		 5kx6 GALACTOSIDE
2-ALPHA-L-FUCOSYLTRA
NSFERASE
(Arabidopsis
thaliana) 		5 / 9 THR A 416
GLY A 485
PHE A 484
LEU A 470
SER A 482
 GDP  A 601 (-4.1A)
None
GDP  A 601 (-3.9A)
None
None
 1.23A 1l5lA-5kx6A:
undetectable		 1l5lA-5kx6A:
20.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1L5L_A_NIOA991_1
(NICOTINATE-NUCLEOTID
E--DIMETHYLBENZIMIDA
ZOLE
PHOSPHORIBOSYLTRANSF
ERASE)		 5ub8 LIKELY RAB FAMILY
GTP-BINDING PROTEIN
(Candida
albicans) 		5 / 9 THR A  71
GLY A  73
GLY A  27
GLU A  75
ARG A  76
 None
ZN  A 302 ( 4.7A)
GDP  A 301 (-3.1A)
GDP  A 301 ( 4.8A)
None
 1.24A 1l5lA-5ub8A:
undetectable		 1l5lA-5ub8A:
19.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1L5M_A_NIOA991_1
(NICOTINATE-NUCLEOTID
E--DIMETHYLBENZIMIDA
ZOLE
PHOSPHORIBOSYLTRANSF
ERASE)		 5kx6 GALACTOSIDE
2-ALPHA-L-FUCOSYLTRA
NSFERASE
(Arabidopsis
thaliana) 		5 / 9 THR A 416
GLY A 485
PHE A 484
LEU A 470
SER A 482
 GDP  A 601 (-4.1A)
None
GDP  A 601 (-3.9A)
None
None
 1.23A 1l5mA-5kx6A:
undetectable		 1l5mA-5kx6A:
20.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1L5M_A_NIOA991_1
(NICOTINATE-NUCLEOTID
E--DIMETHYLBENZIMIDA
ZOLE
PHOSPHORIBOSYLTRANSF
ERASE)		 5ub8 LIKELY RAB FAMILY
GTP-BINDING PROTEIN
(Candida
albicans) 		5 / 9 THR A  71
GLY A  73
GLY A  27
GLU A  75
ARG A  76
 None
ZN  A 302 ( 4.7A)
GDP  A 301 (-3.1A)
GDP  A 301 ( 4.8A)
None
 1.23A 1l5mA-5ub8A:
undetectable		 1l5mA-5ub8A:
19.49
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1MF1_A_ACTA458_0
(ADENYLOSUCCINATE
SYNTHETASE)		 1cg4 PROTEIN
(ADENYLOSUCCINATE
SYNTHETASE)
(Escherichia
coli) 		4 / 4 GLY A  15
LYS A  16
GLY A  17
HIS A  41
 GDP  A 432 (-3.3A)
IMO  A 440 ( 2.9A)
GDP  A 432 (-3.6A)
GDP  A 432 (-3.6A)
 0.32A 1mf1A-1cg4A:
57.4		 1mf1A-1cg4A:
42.66
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1MF1_A_ACTA458_0
(ADENYLOSUCCINATE
SYNTHETASE)		 1dj2 ADENYLOSUCCINATE
SYNTHETASE
(Arabidopsis
thaliana) 		4 / 4 GLY A  33
LYS A  34
GLY A  35
HIS A  59
 GDP  A 500 (-2.7A)
GDP  A 500 (-2.5A)
GDP  A 500 (-4.0A)
GDP  A 500 (-3.2A)
 0.45A 1mf1A-1dj2A:
58.3		 1mf1A-1dj2A:
48.41
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1MF1_A_ACTA458_0
(ADENYLOSUCCINATE
SYNTHETASE)		 1dj3 ADENYLOSUCCINATE
SYNTHETASE
(Triticum
aestivum) 		4 / 4 GLY A  32
LYS A  33
GLY A  34
HIS A  58
 GDP  A 500 (-3.3A)
GDP  A 500 (-2.7A)
GDP  A 500 (-3.6A)
GDP  A 500 (-3.2A)
 0.42A 1mf1A-1dj3A:
56.1		 1mf1A-1dj3A:
48.40
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1MF1_A_ACTA458_0
(ADENYLOSUCCINATE
SYNTHETASE)		 1p9b ADENYLOSUCCINATE
SYNTHETASE
(Plasmodium
falciparum) 		4 / 4 GLY A  28
LYS A  29
GLY A  30
HIS A  54
 GDP  A1603 (-3.4A)
IMO  A1601 ( 2.8A)
GDP  A1603 (-3.7A)
IMO  A1601 ( 3.7A)
 0.23A 1mf1A-1p9bA:
58.0		 1mf1A-1p9bA:
42.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJO_C_SAMC200_0
(METHIONINE REPRESSOR)		 2y4l MANNOSYLGLYCERATE
SYNTHASE
(Rhodothermus
marinus) 		5 / 12 ALA A  83
GLY A  79
GLU A  90
GLU A  31
LEU A  33
 None
GDP  A 401 ( 3.8A)
None
None
None
 1.30A 1mjoC-2y4lA:
undetectable
1mjoD-2y4lA:
undetectable		 1mjoC-2y4lA:
13.03
1mjoD-2y4lA:
13.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJQ_A_SAMA200_0
(METHIONINE REPRESSOR)		 2y4l MANNOSYLGLYCERATE
SYNTHASE
(Rhodothermus
marinus) 		5 / 11 GLU A  90
GLU A  31
LEU A  33
ALA A  83
GLY A  79
 None
None
None
None
GDP  A 401 ( 3.8A)
 1.30A 1mjqA-2y4lA:
undetectable
1mjqB-2y4lA:
undetectable		 1mjqA-2y4lA:
13.03
1mjqB-2y4lA:
13.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJQ_C_SAMC199_0
(METHIONINE REPRESSOR)		 2y4l MANNOSYLGLYCERATE
SYNTHASE
(Rhodothermus
marinus) 		5 / 10 GLU A  90
GLU A  31
LEU A  33
ALA A  83
GLY A  79
 None
None
None
None
GDP  A 401 ( 3.8A)
 1.28A 1mjqC-2y4lA:
undetectable
1mjqD-2y4lA:
undetectable		 1mjqC-2y4lA:
13.03
1mjqD-2y4lA:
13.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJQ_G_SAMG199_0
(METHIONINE REPRESSOR)		 2y4l MANNOSYLGLYCERATE
SYNTHASE
(Rhodothermus
marinus) 		5 / 10 GLU A  90
GLU A  31
LEU A  33
ALA A  83
GLY A  79
 None
None
None
None
GDP  A 401 ( 3.8A)
 1.29A 1mjqG-2y4lA:
undetectable
1mjqH-2y4lA:
undetectable		 1mjqG-2y4lA:
13.03
1mjqH-2y4lA:
13.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJQ_I_SAMI199_0
(METHIONINE REPRESSOR)		 2y4l MANNOSYLGLYCERATE
SYNTHASE
(Rhodothermus
marinus) 		5 / 11 GLU A  90
GLU A  31
LEU A  33
ALA A  83
GLY A  79
 None
None
None
None
GDP  A 401 ( 3.8A)
 1.28A 1mjqI-2y4lA:
undetectable
1mjqJ-2y4lA:
undetectable		 1mjqI-2y4lA:
13.03
1mjqJ-2y4lA:
13.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MRQ_A_STRA501_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C1)		 1rpn GDP-MANNOSE
4,6-DEHYDRATASE
(Pseudomonas
aeruginosa) 		5 / 11 LEU A 286
GLU A 282
VAL A 283
GLU A 181
TRP A 220
 None
GDP  A1601 (-2.6A)
None
NDP  A1501 ( 4.7A)
None
 1.17A 1mrqA-1rpnA:
undetectable		 1mrqA-1rpnA:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MX1_C_THAC3_1
(LIVER
CARBOXYLESTERASE I)		 5d3q DYNAMIN-1,DYNAMIN-1
(Homo
sapiens) 		5 / 12 THR A 205
VAL A 174
LEU A 134
LEU A 172
LEU A  71
 GDP  A 801 ( 4.8A)
None
None
None
None
 1.18A 1mx1C-5d3qA:
1.9		 1mx1C-5d3qA:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N2X_B_SAMB402_0
(S-ADENOSYL-METHYLTRA
NSFERASE MRAW)		 4c7o SIGNAL RECOGNITION
PARTICLE PROTEIN
(Escherichia
coli) 		5 / 12 THR A 115
GLY A 112
GLY A 110
VAL A 220
GLY A 276
 GDP  A1003 (-3.5A)
GDP  A1003 (-3.2A)
GDP  A1003 ( 3.2A)
None
GDP  A1003 (-3.4A)
 0.95A 1n2xB-4c7oA:
2.6		 1n2xB-4c7oA:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NT2_A_SAMA301_0
(FIBRILLARIN-LIKE
PRE-RRNA PROCESSING
PROTEIN)		 1z0f RAB14, MEMBER RAS
ONCOGENE FAMILY
(Homo
sapiens) 		5 / 12 GLY A 123
ALA A 153
SER A 154
TYR A 136
ALA A 139
 None
None
GDP  A 200 (-3.7A)
None
None
 1.19A 1nt2A-1z0fA:
3.7		 1nt2A-1z0fA:
21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NW5_A_SAMA401_1
(MODIFICATION
METHYLASE RSRI)		 2e87 HYPOTHETICAL PROTEIN
PH1320
(Pyrococcus
horikoshii) 		3 / 3 ASP A 291
HIS A 259
ASP A 294
 GDP  A 400 (-2.8A)
None
None
 0.84A 1nw5A-2e87A:
undetectable		 1nw5A-2e87A:
23.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OIP_A_VIVA1278_1
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)		 2x77 ADP-RIBOSYLATION
FACTOR
(Leishmania
major) 		4 / 5 SER A 163
SER A 161
VAL A  94
PHE A 127
 GDP  A 188 (-4.2A)
None
None
None
 1.48A 1oipA-2x77A:
undetectable		 1oipA-2x77A:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OLT_A_SAMA501_0
(OXYGEN-INDEPENDENT
COPROPORPHYRINOGEN
III OXIDASE)		 4zv4 ELONGATION FACTOR TU
(Pseudomonas
aeruginosa) 		5 / 12 ASP A  87
ASP A  51
ILE A  50
PHE A  47
ALA A  31
 None
GDP  A 501 ( 4.6A)
None
None
None
 1.38A 1oltA-4zv4A:
undetectable		 1oltA-4zv4A:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P91_A_SAMA1401_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE A)		 5w3j TUBULIN BETA CHAIN
(Saccharomyces
cerevisiae) 		5 / 11 LEU B 139
GLY B 146
GLY B 144
ILE B 152
LEU B 418
 None
None
GDP  B 501 (-4.6A)
None
None
 1.09A 1p91A-5w3jB:
undetectable		 1p91A-5w3jB:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P91_B_SAMB2401_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE A)		 1dj3 ADENYLOSUCCINATE
SYNTHETASE
(Triticum
aestivum) 		5 / 12 TYR A 429
GLY A 435
GLY A 433
LEU A  17
PRO A  42
 None
None
GDP  A 500 (-3.2A)
None
None
 0.91A 1p91B-1dj3A:
undetectable		 1p91B-1dj3A:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P93_A_DEXA1999_1
(GLUCOCORTICOID
RECEPTOR)		 2hjg GTP-BINDING PROTEIN
ENGA
(Bacillus
subtilis) 		5 / 12 ASN A 119
LEU A 121
GLY A  92
THR A  18
ILE A  19
 GDP  A 800 (-3.3A)
None
None
GDP  A 800 (-3.5A)
None
 1.27A 1p93A-2hjgA:
undetectable		 1p93A-2hjgA:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P93_B_DEXB2999_1
(GLUCOCORTICOID
RECEPTOR)		 2r6r CELL DIVISION
PROTEIN FTSZ
(Aquifex
aeolicus) 		5 / 12 GLY 1 100
MET 1 140
LEU 1 147
ILE 1 165
PHE 1 132
 GDP  1 339 (-3.3A)
None
None
None
None
 1.46A 1p93B-2r6r1:
undetectable		 1p93B-2r6r1:
20.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PHG_A_MYTA422_1
(CYTOCHROME P450-CAM)		 2nty RAC-LIKE GTP-BINDING
PROTEIN ARAC5
(Arabidopsis
thaliana) 		5 / 11 PHE C 170
THR C  11
GLY C  18
VAL C 116
ILE C  82
 None
None
GDP  C1200 (-2.6A)
None
None
 1.14A 1phgA-2ntyC:
undetectable		 1phgA-2ntyC:
19.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PK7_B_ADNB1246_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 1rpn GDP-MANNOSE
4,6-DEHYDRATASE
(Pseudomonas
aeruginosa) 		4 / 8 ARG A 218
GLY A 212
VAL A 214
ILE A 273
 GDP  A1601 (-3.0A)
GDP  A1601 (-3.3A)
None
None
 0.79A 1pk7B-1rpnA:
3.2		 1pk7B-1rpnA:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RJD_A_SAMA801_0
(CARBOXY METHYL
TRANSFERASE FOR
PROTEIN PHOSPHATASE
2A CATALYTIC SUBUNIT)		 5tc3 INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE
(Eremothecium
gossypii) 		5 / 12 ILE A 202
GLN A 201
THR A 206
LEU A 196
LEU A 224
 None
None
None
GDP  A 603 ( 4.6A)
GDP  A 603 ( 4.3A)
 1.02A 1rjdA-5tc3A:
undetectable		 1rjdA-5tc3A:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RJD_B_SAMB802_0
(CARBOXY METHYL
TRANSFERASE FOR
PROTEIN PHOSPHATASE
2A CATALYTIC SUBUNIT)		 5tc3 INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE
(Eremothecium
gossypii) 		5 / 12 ILE A 202
GLN A 201
THR A 206
LEU A 196
LEU A 224
 None
None
None
GDP  A 603 ( 4.6A)
GDP  A 603 ( 4.3A)
 1.04A 1rjdB-5tc3A:
undetectable		 1rjdB-5tc3A:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RJD_C_SAMC803_0
(CARBOXY METHYL
TRANSFERASE FOR
PROTEIN PHOSPHATASE
2A CATALYTIC SUBUNIT)		 5tc3 INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE
(Eremothecium
gossypii) 		5 / 12 ILE A 202
GLN A 201
THR A 206
LEU A 196
LEU A 224
 None
None
None
GDP  A 603 ( 4.6A)
GDP  A 603 ( 4.3A)
 1.03A 1rjdC-5tc3A:
undetectable		 1rjdC-5tc3A:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RLB_E_REAE176_1
(RETINOL BINDING
PROTEIN)		 5uzh NAFOA.00085.B
(Naegleria
fowleri) 		5 / 10 ALA A 299
ALA A 297
VAL A 228
LEU A 249
PHE A 360
 None
None
GDP  A 401 (-3.7A)
GDP  A 401 (-3.9A)
None
 1.17A 1rlbE-5uzhA:
undetectable		 1rlbE-5uzhA:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SH9_B_RITB301_1
(POL POLYPROTEIN)		 1xje RIBONUCLEOTIDE
REDUCTASE,
B12-DEPENDENT
(Thermotoga
maritima) 		5 / 8 ASP A 339
ALA A 498
ASP A 499
ILE A  88
GLY A 492
 None
None
None
None
GDP  A1002 (-3.8A)
 1.48A 1sh9A-1xjeA:
undetectable		 1sh9A-1xjeA:
10.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TMX_A_BEZA881_0
(HYDROXYQUINOL
1,2-DIOXYGENASE)		 1dj2 ADENYLOSUCCINATE
SYNTHETASE
(Arabidopsis
thaliana) 		5 / 11 LEU A 270
GLY A 240
ARG A  50
HIS A  59
VAL A  91
 None
None
None
GDP  A 500 (-3.2A)
None
 1.31A 1tmxA-1dj2A:
undetectable		 1tmxA-1dj2A:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TNL_A_TPAA900_1
(TRYPSIN)		 1zca G ALPHA I/12
(Mus
musculus) 		4 / 6 SER A  66
SER A  69
GLY A 228
GLY A  62
 GDP  A 382 (-2.9A)
MG  A 383 ( 2.1A)
ALF  A 384 (-3.3A)
None
 0.77A 1tnlA-1zcaA:
undetectable		 1tnlA-1zcaA:
18.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TNL_A_TPAA900_1
(TRYPSIN)		 3cx6 GUANINE
NUCLEOTIDE-BINDING
PROTEIN ALPHA-13
SUBUNIT
(Mus
musculus) 		4 / 6 SER A  59
SER A  62
GLY A 225
GLY A  55
 GDP  A 775 (-3.4A)
MG  A 675 ( 2.7A)
None
None
 0.75A 1tnlA-3cx6A:
undetectable		 1tnlA-3cx6A:
20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TNL_A_TPAA900_1
(TRYPSIN)		 3cx6 GUANINE
NUCLEOTIDE-BINDING
PROTEIN ALPHA-13
SUBUNIT
(Mus
musculus) 		5 / 6 SER A 268
SER A 248
VAL A 247
GLY A  57
GLY A  55
 None
None
None
GDP  A 775 ( 4.2A)
None
 1.19A 1tnlA-3cx6A:
undetectable		 1tnlA-3cx6A:
20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TNL_A_TPAA900_1
(TRYPSIN)		 6au6 GUANINE
NUCLEOTIDE-BINDING
PROTEIN G(S) SUBUNIT
ALPHA ISOFORMS SHORT
(Homo
sapiens) 		4 / 6 SER A  51
SER A  54
GLY A 226
GLY A  47
 GDP  A 401 (-3.4A)
MG  A 402 ( 2.1A)
None
None
 0.68A 1tnlA-6au6A:
undetectable		 1tnlA-6au6A:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1USQ_F_CLMF1144_0
(DR HEMAGGLUTININ
STRUCTURAL SUBUNIT)		 2vaw CELL DIVISION
PROTEIN FTSZ
(Pseudomonas
aeruginosa) 		4 / 7 PRO A  63
GLY A  68
THR A 109
GLY A  70
 None
None
GDP  A1317 (-4.0A)
None
 0.79A 1usqF-2vawA:
undetectable		 1usqF-2vawA:
16.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VPT_A_SAMA400_1
(VP39)		 2j1l RHO-RELATED
GTP-BINDING PROTEIN
RHOD
(Homo
sapiens) 		3 / 3 ASP A 132
ARG A 174
ASP A 136
 GDP  A1194 (-2.9A)
GDP  A1194 (-4.6A)
None
 0.92A 1vptA-2j1lA:
undetectable		 1vptA-2j1lA:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WRL_A_TFPA204_1
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)		 2ik8 GUANINE
NUCLEOTIDE-BINDING
PROTEIN G(I),
ALPHA-1 SUBUNIT
(Homo
sapiens) 		4 / 7 PHE A 336
PHE A 267
VAL A 225
SER A  44
 None
None
None
GDP  A 401 (-3.6A)
 1.05A 1wrlA-2ik8A:
undetectable
1wrlB-2ik8A:
undetectable		 1wrlA-2ik8A:
14.72
1wrlB-2ik8A:
14.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WSV_A_THHA3001_0
(AMINOMETHYLTRANSFERA
SE)		 5tc3 INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE
(Eremothecium
gossypii) 		5 / 12 LEU A 224
ILE A 213
VAL A 221
ASN A 122
LEU A 196
 GDP  A 603 ( 4.3A)
None
None
None
GDP  A 603 ( 4.6A)
 1.22A 1wsvA-5tc3A:
undetectable		 1wsvA-5tc3A:
23.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WSV_B_THHB4001_0
(AMINOMETHYLTRANSFERA
SE)		 5tc3 INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE
(Eremothecium
gossypii) 		5 / 12 LEU A 224
ILE A 213
VAL A 221
ASN A 122
LEU A 196
 GDP  A 603 ( 4.3A)
None
None
None
GDP  A 603 ( 4.6A)
 1.23A 1wsvB-5tc3A:
undetectable		 1wsvB-5tc3A:
23.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1X70_B_715B801_1
(DIPEPTIDYL PEPTIDASE
IV)		 5vys GDP-MANNOSE
4,6-DEHYDRATASE /
GDP-4-AMINO-4,6-DIDE
OXY-D-MANNOSE
FORMYLTRANSFERASE
(Brucella
melitensis) 		5 / 12 ARG A 201
VAL A  37
TYR A  87
ASN A  46
HIS A  50
 GDP  A 303 (-3.7A)
None
None
None
None
 1.43A 1x70B-5vysA:
undetectable		 1x70B-5vysA:
17.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XOZ_A_CIAA501_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		 4djt GTP-BINDING NUCLEAR
PROTEIN GSP1
(Encephalitozoon
cuniculi) 		5 / 12 ALA A 152
ILE A 150
VAL A  18
LEU A  99
ILE A 131
 GDP  A 301 (-3.7A)
None
GDP  A 301 (-3.9A)
None
None
 1.04A 1xozA-4djtA:
undetectable		 1xozA-4djtA:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XVA_A_SAMA293_0
(GLYCINE
N-METHYLTRANSFERASE)		 5c2k TRANSFORMING PROTEIN
RHOA,RAC
GTPASE-ACTIVATING
PROTEIN 1
(Homo
sapiens) 		5 / 12 TYR A  34
VAL A 361
ASP A  65
HIS A 278
GLY A  17
 GDP  A 503 (-4.7A)
None
None
None
GDP  A 503 (-3.2A)
 1.45A 1xvaA-5c2kA:
undetectable		 1xvaA-5c2kA:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YC2_D_NCAD510_0
(NAD-DEPENDENT
DEACETYLASE 2)		 5h7k ELONGATION FACTOR 2
(Pyrococcus
horikoshii) 		4 / 5 ALA A 124
PHE A 171
ILE A 157
ASP A 154
 None
None
None
GDP  A 501 (-2.8A)
 1.11A 1yc2D-5h7kA:
undetectable		 1yc2D-5h7kA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YKI_A_NFZA1219_1
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 3cph RAS-RELATED PROTEIN
SEC4
(Saccharomyces
cerevisiae) 		4 / 8 TYR A 100
ASN A 133
GLU A 160
GLY A 132
 None
GDP  A 302 (-3.4A)
None
None
 1.08A 1ykiA-3cphA:
undetectable
1ykiB-3cphA:
undetectable		 1ykiA-3cphA:
23.71
1ykiB-3cphA:
23.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YKI_B_NFZB2219_1
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 3cph RAS-RELATED PROTEIN
SEC4
(Saccharomyces
cerevisiae) 		4 / 8 TYR A 100
ASN A 133
GLU A 160
GLY A 132
 None
GDP  A 302 (-3.4A)
None
None
 1.08A 1ykiA-3cphA:
undetectable
1ykiB-3cphA:
undetectable		 1ykiA-3cphA:
23.71
1ykiB-3cphA:
23.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
209D_C_DVAC8_0
(N8-ACTINOMYCIN D)		 1ofu CELL DIVISION
PROTEIN FTSZ
(Pseudomonas
aeruginosa) 		3 / 3 THR A 163
THR A 133
PRO A 165
 None
GDP  A1318 ( 4.9A)
None
 0.88A 209dC-1ofuA:
undetectable		 209dC-1ofuA:
6.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A1M_B_CAMB2422_0
(CYTOCHROME P450-CAM)		 1ukv GTP-BINDING PROTEIN
YPT1
(Saccharomyces
cerevisiae) 		4 / 8 THR Y  64
VAL Y  19
GLY Y  20
ILE Y  86
 None
GDP  Y1207 (-4.1A)
GDP  Y1207 (-2.9A)
None
 0.82A 2a1mB-1ukvY:
undetectable		 2a1mB-1ukvY:
18.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AKE_A_TRPA479_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 2nzx ALPHA1,3-FUCOSYLTRAN
SFERASE
(Helicobacter
pylori) 		5 / 12 TYR A  92
THR A  93
GLY A  94
GLU A 249
LYS A 250
 None
None
None
GDP  A3001 (-3.9A)
GDP  A3001 (-2.9A)
 1.16A 2akeA-2nzxA:
undetectable		 2akeA-2nzxA:
24.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AOJ_C_FRDC305_1
(POL POLYPROTEIN
PEPTIDE INHIBITOR)		 2r6r CELL DIVISION
PROTEIN FTSZ
(Aquifex
aeolicus) 		4 / 5 LEU 1  79
GLY 1 104
PRO 1 111
VAL 1 112
 None
GDP  1 339 (-3.4A)
None
None
 0.81A 2aojA-2r6r1:
undetectable		 2aojA-2r6r1:
16.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AZQ_A_PCFA954_0
(CATECHOL
1,2-DIOXYGENASE)		 4tz0 ATP-DEPENDENT RNA
HELICASE MSS116,
MITOCHONDRIAL
(Saccharomyces
cerevisiae) 		5 / 9 LEU A 246
ALA A 193
LEU A 194
GLU A 199
LEU A 163
 None
None
None
GDP  A 601 ( 4.2A)
None
 1.32A 2azqA-4tz0A:
undetectable		 2azqA-4tz0A:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2B25_A_SAMA601_0
(HYPOTHETICAL PROTEIN)		 2erx GTP-BINDING PROTEIN
DI-RAS2
(Homo
sapiens) 		5 / 12 THR A  39
GLY A  19
GLY A  17
GLY A  64
ASP A 124
 MG  A 403 ( 3.0A)
GDP  A 401 (-3.2A)
GDP  A 401 (-3.3A)
PO4  A 402 (-3.3A)
GDP  A 401 (-2.9A)
 1.05A 2b25A-2erxA:
undetectable		 2b25A-2erxA:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2B25_A_SAMA601_0
(HYPOTHETICAL PROTEIN)		 4jvs RAS-RELATED PROTEIN
RAB-1A
(Homo
sapiens) 		5 / 12 THR B  43
GLY B  23
GLY B  21
GLY B  69
ASP B 127
 MG  B 402 (-2.8A)
GDP  B 400 (-3.0A)
GDP  B 400 ( 3.5A)
AF3  B 401 (-3.7A)
GDP  B 400 (-2.8A)
 1.02A 2b25A-4jvsB:
undetectable		 2b25A-4jvsB:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2B25_A_SAMA601_0
(HYPOTHETICAL PROTEIN)		 4m8n RAS-RELATED PROTEIN
RAP-1B
(Homo
sapiens) 		5 / 12 THR E  35
GLY E  15
GLY E  13
GLY E  60
ASP E 119
 MG  E 200 (-2.7A)
GDP  E 201 (-3.6A)
GDP  E 201 ( 3.1A)
AF3  E 202 (-3.3A)
GDP  E 201 (-2.8A)
 1.03A 2b25A-4m8nE:
undetectable		 2b25A-4m8nE:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BFP_B_H4BB1290_1
(PTERIDINE REDUCTASE
1)		 2w6d DYNAMIN FAMILY
PROTEIN
(Nostoc
punctiforme) 		4 / 8 ARG A 299
SER A 292
LEU A 205
LEU A 171
 None
GDP  A1696 (-4.6A)
None
None
 0.97A 2bfpB-2w6dA:
undetectable		 2bfpB-2w6dA:
18.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BM9_A_SAMA301_1
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 1z6y ADP-RIBOSYLATION
FACTOR-LIKE PROTEIN
5
(Homo
sapiens) 		3 / 3 LYS A 126
ASP A  66
ASN A  26
 GDP  A 180 (-3.2A)
GDP  A 180 ( 4.3A)
GDP  A 180 (-3.2A)
 1.16A 2bm9A-1z6yA:
2.7		 2bm9A-1z6yA:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXG_A_IBPA2001_1
(SERUM ALBUMIN)		 3tr5 PEPTIDE CHAIN
RELEASE FACTOR 3
(Coxiella
burnetii) 		5 / 11 VAL A 261
GLY A 260
ALA A 255
LEU A  26
SER A  17
 None
None
GDP  A 527 (-4.2A)
None
GDP  A 527 ( 4.4A)
 1.17A 2bxgA-3tr5A:
undetectable		 2bxgA-3tr5A:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2C12_D_SPMD1434_1
(NITROALKANE OXIDASE)		 3v70 GTPASE IMAP FAMILY
MEMBER 1
(Homo
sapiens) 		5 / 10 GLN A 120
VAL A 118
ALA A  38
SER A  41
ASP A  82
 GDP  A 401 (-4.1A)
None
GDP  A 401 (-4.0A)
MG  A 402 ( 2.2A)
MG  A 402 ( 4.0A)
 1.44A 2c12D-3v70A:
undetectable		 2c12D-3v70A:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2C8A_A_NCAA1252_0
(MONO-ADP-RIBOSYLTRAN
SFERASE C3)		 5zj5 -
(-) 		4 / 7 ARG A  81
SER A 121
GLN A 162
GLU A 164
 NAI  A 301 (-2.7A)
NAI  A 301 (-2.7A)
GDP  A 302 ( 3.2A)
NAI  A 301 (-3.5A)
 0.57A 2c8aA-5zj5A:
3.0		 2c8aA-5zj5A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2C8A_A_NCAA1252_0
(MONO-ADP-RIBOSYLTRAN
SFERASE C3)		 5zj5 -
(-) 		4 / 7 SER A 121
SER A 123
GLN A 162
GLU A 164
 NAI  A 301 (-2.7A)
None
GDP  A 302 ( 3.2A)
NAI  A 301 (-3.5A)
 0.65A 2c8aA-5zj5A:
3.0		 2c8aA-5zj5A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2C8A_B_NCAB1246_0
(MONO-ADP-RIBOSYLTRAN
SFERASE C3)		 3cx6 GUANINE
NUCLEOTIDE-BINDING
PROTEIN ALPHA-13
SUBUNIT
(Mus
musculus) 		4 / 7 GLY A 225
SER A  59
ARG A 230
GLU A 251
 None
GDP  A 775 (-3.4A)
None
None
 1.06A 2c8aB-3cx6A:
undetectable		 2c8aB-3cx6A:
20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2C8A_C_NCAC1252_0
(MONO-ADP-RIBOSYLTRAN
SFERASE C3)		 1z2a RAS-RELATED PROTEIN
RAB-23
(Mus
musculus) 		4 / 6 ARG A  28
SER A 151
PHE A  34
GLU A 154
 None
GDP  A 201 (-3.6A)
GDP  A 201 (-4.4A)
None
 1.45A 2c8aC-1z2aA:
undetectable		 2c8aC-1z2aA:
19.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2C8A_C_NCAC1252_0
(MONO-ADP-RIBOSYLTRAN
SFERASE C3)		 2gf9 RAS-RELATED PROTEIN
RAB-3D
(Homo
sapiens) 		4 / 6 ARG A  41
SER A 165
PHE A  47
GLU A 168
 None
GDP  A 501 (-3.1A)
GDP  A 501 ( 4.4A)
None
 1.33A 2c8aC-2gf9A:
undetectable		 2c8aC-2gf9A:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CDQ_B_SAMB1500_0
(ASPARTOKINASE)		 5yew MITOFUSIN-1,MITOFUSI
N-1 FUSION PROTEIN
(Homo
sapiens) 		4 / 7 SER B 284
ASP B 240
ARG B 253
GLU B 316
 GDP  B 801 (-3.1A)
GDP  B 801 (-3.0A)
None
None
 1.10A 2cdqB-5yewB:
undetectable		 2cdqB-5yewB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DTJ_A_THRA401_0
(ASPARTOKINASE)		 4xcq TUBZ
(Clostridium
phage
c-st) 		4 / 8 GLY A  14
ALA A  94
ASN A  34
ILE A  10
 None
None
GDP  A 401 ( 4.6A)
None
 0.83A 2dtjA-4xcqA:
undetectable
2dtjB-4xcqA:
undetectable		 2dtjA-4xcqA:
21.18
2dtjB-4xcqA:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2E7F_B_C2FB4000_0
(5-METHYLTETRAHYDROFO
LATE CORRINOID/IRON
SULFUR PROTEIN
METHYLTRANSFERASE)		 1ofu CELL DIVISION
PROTEIN FTSZ
(Pseudomonas
aeruginosa) 		5 / 12 GLU A 139
PHE A 183
ILE A 151
LEU A 154
GLY A 106
 GDP  A1318 (-2.8A)
GDP  A1318 (-3.8A)
None
None
GDP  A1318 ( 4.3A)
 1.31A 2e7fB-1ofuA:
2.7		 2e7fB-1ofuA:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2E7F_B_C2FB4000_0
(5-METHYLTETRAHYDROFO
LATE CORRINOID/IRON
SULFUR PROTEIN
METHYLTRANSFERASE)		 2vaw CELL DIVISION
PROTEIN FTSZ
(Pseudomonas
aeruginosa) 		5 / 12 GLU A 139
PHE A 183
ILE A 151
LEU A 154
GLY A 106
 GDP  A1317 (-2.4A)
GDP  A1317 (-4.5A)
None
None
GDP  A1317 ( 4.0A)
 1.26A 2e7fB-2vawA:
2.7		 2e7fB-2vawA:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EJ3_B_GBNB914_1
(BRANCHED-CHAIN AMINO
ACID
AMINOTRANSFERASE)		 2r6r CELL DIVISION
PROTEIN FTSZ
(Aquifex
aeolicus) 		5 / 10 GLY 1  14
GLY 1 106
THR 1 105
ALA 1 109
ALA 1 110
 None
GDP  1 339 (-3.5A)
GDP  1 339 (-4.3A)
None
None
 1.08A 2ej3B-2r6r1:
undetectable		 2ej3B-2r6r1:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EJ3_C_GBNC1414_1
(BRANCHED-CHAIN AMINO
ACID
AMINOTRANSFERASE)		 2r6r CELL DIVISION
PROTEIN FTSZ
(Aquifex
aeolicus) 		5 / 8 GLY 1  14
GLY 1 106
THR 1 105
ALA 1 109
ALA 1 110
 None
GDP  1 339 (-3.5A)
GDP  1 339 (-4.3A)
None
None
 1.11A 2ej3C-2r6r1:
undetectable		 2ej3C-2r6r1:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EJ3_C_GBNC1414_1
(BRANCHED-CHAIN AMINO
ACID
AMINOTRANSFERASE)		 2r6r CELL DIVISION
PROTEIN FTSZ
(Aquifex
aeolicus) 		5 / 8 GLY 1 102
GLY 1 100
THR 1 129
ALA 1 128
ALA 1  99
 GDP  1 339 ( 4.5A)
GDP  1 339 (-3.3A)
None
None
None
 1.35A 2ej3C-2r6r1:
undetectable		 2ej3C-2r6r1:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EJT_A_SAMA501_0
(N(2),N(2)-DIMETHYLGU
ANOSINE TRNA
METHYLTRANSFERASE)		 3zid TUBULIN/FTSZ, GTPASE
(Methanothrix
thermoacetophila) 		5 / 12 LEU A  17
ILE A 193
ASN A  14
ALA A  47
PHE A 107
 None
GDP  A 999 (-3.5A)
None
None
None
 1.15A 2ejtA-3zidA:
2.5		 2ejtA-3zidA:
23.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F8G_B_017B401_1
(POL POLYPROTEIN)		 2fpg SUCCINYL-COA LIGASE
[GDP-FORMING]
BETA-CHAIN,
MITOCHONDRIAL
(Sus
scrofa) 		5 / 12 LEU B  88
GLY B  52
ALA B  51
VAL B 100
ILE B  49
 None
GDP  B 397 (-3.4A)
None
None
None
 1.05A 2f8gA-2fpgB:
undetectable		 2f8gA-2fpgB:
13.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HMY_B_SAMB328_0
(PROTEIN
(CYTOSINE-SPECIFIC
METHYLTRANSFERASE
HHAI))		 4b46 CELL DIVISION
PROTEIN FTSZ
(Haloferax
volcanii) 		5 / 12 PHE A 167
GLY A 135
ASN A 169
ILE A 186
VAL A 228
 None
None
GDP  A1368 (-3.3A)
GDP  A1368 (-4.2A)
None
 1.02A 2hmyB-4b46A:
4.1		 2hmyB-4b46A:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HS2_A_017A201_1
(PROTEASE)		 2fpg SUCCINYL-COA LIGASE
[GDP-FORMING]
BETA-CHAIN,
MITOCHONDRIAL
(Sus
scrofa) 		5 / 12 LEU B  88
GLY B  52
ALA B  51
VAL B 100
ILE B  49
 None
GDP  B 397 (-3.4A)
None
None
None
 1.00A 2hs2A-2fpgB:
undetectable		 2hs2A-2fpgB:
13.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HYY_B_STIB600_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 4v0k ARF-LIKE SMALL
GTPASE
(Chlamydomonas
reinhardtii) 		4 / 6 LEU A 163
VAL A  20
VAL A  93
ILE A  34
 GDP  A 700 (-4.4A)
None
None
None
 0.85A 2hyyB-4v0kA:
undetectable		 2hyyB-4v0kA:
22.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IGT_B_SAMB1002_1
(SAM DEPENDENT
METHYLTRANSFERASE)		 2x77 ADP-RIBOSYLATION
FACTOR
(Leishmania
major) 		3 / 3 ASP A 135
ASP A 132
ASP A  99
 None
GDP  A 188 (-2.6A)
None
 0.65A 2igtB-2x77A:
undetectable		 2igtB-2x77A:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J2P_B_SC2B1294_1
(FICOLIN-2)		 2cjw GTP-BINDING PROTEIN
GEM
(Homo
sapiens) 		5 / 9 VAL A  86
GLY A  82
LEU A 154
LEU A 129
ASP A 131
 GDP  A 999 (-4.1A)
None
None
None
MG  A1000 ( 4.1A)
 1.01A 2j2pB-2cjwA:
0.0
2j2pC-2cjwA:
0.0		 2j2pB-2cjwA:
21.15
2j2pC-2cjwA:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J2P_B_SC2B1294_1
(FICOLIN-2)		 2dyk GTP-BINDING PROTEIN
(Thermus
thermophilus) 		5 / 9 VAL A  12
GLY A   8
LEU A  84
LEU A  53
ASP A  55
 GDP  A 501 (-4.1A)
None
None
None
GDP  A 501 ( 4.9A)
 1.11A 2j2pB-2dykA:
undetectable
2j2pC-2dykA:
undetectable		 2j2pB-2dykA:
19.00
2j2pC-2dykA:
19.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J2P_B_SC2B1294_1
(FICOLIN-2)		 2ht6 GTP-BINDING PROTEIN
GEM
(Homo
sapiens) 		5 / 9 VAL A  86
GLY A  82
LEU A 154
LEU A 129
ASP A 131
 GDP  A 545 (-4.1A)
None
None
None
MG  A 344 ( 4.1A)
 0.94A 2j2pB-2ht6A:
undetectable
2j2pC-2ht6A:
undetectable		 2j2pB-2ht6A:
21.43
2j2pC-2ht6A:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JKJ_E_CLME1141_0
(DR HEMAGGLUTININ
STRUCTURAL SUBUNIT)		 2vaw CELL DIVISION
PROTEIN FTSZ
(Pseudomonas
aeruginosa) 		4 / 7 PRO A  63
GLY A  68
THR A 109
GLY A  70
 None
None
GDP  A1317 (-4.0A)
None
 0.81A 2jkjE-2vawA:
undetectable		 2jkjE-2vawA:
16.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JKL_E_CLME1143_0
(DR HEMAGGLUTININ
STRUCTURAL SUBUNIT)		 2vaw CELL DIVISION
PROTEIN FTSZ
(Pseudomonas
aeruginosa) 		4 / 7 PRO A  63
GLY A  68
THR A 109
GLY A  70
 None
None
GDP  A1317 (-4.0A)
None
 0.84A 2jklE-2vawA:
undetectable		 2jklE-2vawA:
16.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2KAW_A_SUZA91_1
(SEGMENT POLARITY
PROTEIN DISHEVELLED
HOMOLOG DVL-1)		 1p9b ADENYLOSUCCINATE
SYNTHETASE
(Plasmodium
falciparum) 		5 / 11 LEU A 340
GLY A 425
ILE A 424
ILE A 421
MET A 433
 None
GDP  A1603 (-3.2A)
None
None
None
 1.03A 2kawA-1p9bA:
undetectable		 2kawA-1p9bA:
14.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2M2P_B_DHIB24_0
(INSULIN B CHAIN)		 3zbq PHIKZ039
(Pseudomonas
virus
phiKZ) 		3 / 3 TYR A  32
GLY A  13
PHE A  11
 None
GDP  A 999 (-3.6A)
None
 0.71A 2m2pB-3zbqA:
undetectable		 2m2pB-3zbqA:
7.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2O01_A_PQNA5001_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1)		 5kx6 GALACTOSIDE
2-ALPHA-L-FUCOSYLTRA
NSFERASE
(Arabidopsis
thaliana) 		4 / 8 MET A 211
PHE A 215
ALA A 463
LEU A 464
 None
None
GDP  A 601 (-3.3A)
None
 1.05A 2o01A-5kx6A:
undetectable		 2o01A-5kx6A:
19.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OGY_A_C2FA3000_0
(5-METHYLTETRAHYDROFO
LATE CORRINOID/IRON
SULFUR PROTEIN
METHYLTRANSFERASE)		 2vaw CELL DIVISION
PROTEIN FTSZ
(Pseudomonas
aeruginosa) 		5 / 12 GLU A 139
PHE A 183
ILE A 151
LEU A 154
GLY A 106
 GDP  A1317 (-2.4A)
GDP  A1317 (-4.5A)
None
None
GDP  A1317 ( 4.0A)
 1.28A 2ogyA-2vawA:
2.7		 2ogyA-2vawA:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OGY_B_C2FB4000_0
(5-METHYLTETRAHYDROFO
LATE CORRINOID/IRON
SULFUR PROTEIN
METHYLTRANSFERASE)		 2vaw CELL DIVISION
PROTEIN FTSZ
(Pseudomonas
aeruginosa) 		5 / 12 GLU A 139
PHE A 183
ILE A 151
LEU A 154
GLY A 106
 GDP  A1317 (-2.4A)
GDP  A1317 (-4.5A)
None
None
GDP  A1317 ( 4.0A)
 1.29A 2ogyB-2vawA:
2.9		 2ogyB-2vawA:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OTV_A_NCAA1301_0
(CATIONIC TRYPSIN)		 1zca G ALPHA I/12
(Mus
musculus) 		4 / 6 SER A  66
SER A  69
GLY A 228
GLY A  62
 GDP  A 382 (-2.9A)
MG  A 383 ( 2.1A)
ALF  A 384 (-3.3A)
None
 0.73A 2otvA-1zcaA:
undetectable		 2otvA-1zcaA:
18.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OTV_A_NCAA1301_0
(CATIONIC TRYPSIN)		 3cx6 GUANINE
NUCLEOTIDE-BINDING
PROTEIN ALPHA-13
SUBUNIT
(Mus
musculus) 		4 / 6 SER A  59
SER A  62
GLY A 225
GLY A  55
 GDP  A 775 (-3.4A)
MG  A 675 ( 2.7A)
None
None
 0.74A 2otvA-3cx6A:
undetectable		 2otvA-3cx6A:
20.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OTV_A_NCAA1301_0
(CATIONIC TRYPSIN)		 3cx6 GUANINE
NUCLEOTIDE-BINDING
PROTEIN ALPHA-13
SUBUNIT
(Mus
musculus) 		5 / 6 SER A 268
SER A 248
VAL A 247
GLY A  57
GLY A  55
 None
None
None
GDP  A 775 ( 4.2A)
None
 1.18A 2otvA-3cx6A:
undetectable		 2otvA-3cx6A:
20.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OTV_A_NCAA1301_0
(CATIONIC TRYPSIN)		 6au6 GUANINE
NUCLEOTIDE-BINDING
PROTEIN G(S) SUBUNIT
ALPHA ISOFORMS SHORT
(Homo
sapiens) 		4 / 6 SER A  51
SER A  54
GLY A 226
GLY A  47
 GDP  A 401 (-3.4A)
MG  A 402 ( 2.1A)
None
None
 0.71A 2otvA-6au6A:
undetectable		 2otvA-6au6A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OXT_A_SAMA300_0
(NUCLEOSIDE-2'-O-METH
YLTRANSFERASE)		 4b46 CELL DIVISION
PROTEIN FTSZ
(Haloferax
volcanii) 		5 / 12 GLY A 114
GLY A  12
GLY A   9
GLY A 110
VAL A 104
 None
None
GDP  A1368 (-3.3A)
GDP  A1368 (-3.6A)
None
 1.04A 2oxtA-4b46A:
undetectable		 2oxtA-4b46A:
24.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OXT_A_SAMA300_0
(NUCLEOSIDE-2'-O-METH
YLTRANSFERASE)		 4xcq TUBZ
(Clostridium
phage
c-st) 		5 / 12 GLY A 103
GLY A  14
GLY A  11
GLY A  99
ILE A  17
 None
None
GDP  A 401 (-3.4A)
GDP  A 401 (-3.3A)
None
 0.93A 2oxtA-4xcqA:
2.7		 2oxtA-4xcqA:
18.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OXT_A_SAMA300_0
(NUCLEOSIDE-2'-O-METH
YLTRANSFERASE)		 4xcq TUBZ
(Clostridium
phage
c-st) 		5 / 12 GLY A 103
GLY A  14
GLY A  11
GLY A  99
VAL A  93
 None
None
GDP  A 401 (-3.4A)
GDP  A 401 (-3.3A)
None
 0.88A 2oxtA-4xcqA:
2.7		 2oxtA-4xcqA:
18.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OXT_B_SAMB300_0
(NUCLEOSIDE-2'-O-METH
YLTRANSFERASE)		 5w3j TUBULIN BETA CHAIN
(Saccharomyces
cerevisiae) 		6 / 12 GLY B  98
GLY B 148
GLY B 146
GLY B 104
THR B 149
ILE B 135
 GDP  B 501 (-4.4A)
None
None
None
None
None
 1.22A 2oxtB-5w3jB:
undetectable		 2oxtB-5w3jB:
18.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OXT_C_SAMC300_1
(NUCLEOSIDE-2'-O-METH
YLTRANSFERASE)		 4jvs PUTATIVE
UNCHARACTERIZED
PROTEIN
RAS-RELATED PROTEIN
RAB-1A
(Legionella
drancourtii;
Homo
sapiens) 		4 / 4 SER A 593
GLY A 557
HIS A 418
ASP B  95
 None
None
GDP  B 400 ( 4.8A)
None
 1.07A 2oxtC-4jvsA:
undetectable		 2oxtC-4jvsA:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PO5_A_CHDA502_0
(FERROCHELATASE,
MITOCHONDRIAL)		 2hjg GTP-BINDING PROTEIN
ENGA
(Bacillus
subtilis) 		4 / 8 LEU A  55
ARG A  22
LEU A 152
GLY A  15
 None
None
None
GDP  A 800 (-3.1A)
 1.01A 2po5A-2hjgA:
4.8		 2po5A-2hjgA:
22.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QD5_A_CHDA701_0
(FERROCHELATASE)		 2v40 ADENYLOSUCCINATE
SYNTHETASE ISOZYME 2
(Homo
sapiens) 		4 / 8 LEU A  49
ARG A 416
VAL A 445
GLY A 446
 None
None
None
GDP  A1457 (-3.3A)
 0.85A 2qd5A-2v40A:
undetectable		 2qd5A-2v40A:
24.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QO4_A_CHDA130_0
(LIVER-BASIC FATTY
ACID BINDING PROTEIN)		 5tc3 INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE
(Eremothecium
gossypii) 		5 / 12 VAL A 127
THR A 184
MET A 183
ASP A 168
MET A 223
 None
ATP  A 601 (-2.8A)
None
ATP  A 601 (-2.3A)
GDP  A 602 (-4.7A)
 0.87A 2qo4A-5tc3A:
undetectable		 2qo4A-5tc3A:
15.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QO6_A_CHDA130_0
(LIVER-BASIC FATTY
ACID BINDING PROTEIN)		 3kxi GTP-BINDING PROTEIN
(HFLX)
(Sulfolobus
solfataricus) 		5 / 12 LEU A  89
ILE A  93
LEU A  90
VAL A   8
THR A 188
 None
None
None
None
GDP  A 500 (-4.7A)
 1.07A 2qo6A-3kxiA:
undetectable		 2qo6A-3kxiA:
16.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RK8_A_PPFA3969_1
(PHOSPHOENOLPYRUVATE
CARBOXYKINASE,
CYTOSOLIC [GTP])		 5dn8 GTPASE DER
(Coxiella
burnetii) 		4 / 8 ARG A 236
SER A 189
ASP A 229
ALA A 237
 GDP  A 501 (-2.9A)
GDP  A 501 (-4.5A)
None
None
 1.19A 2rk8A-5dn8A:
2.3		 2rk8A-5dn8A:
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_A_KLNA1500_1
(CYTOCHROME P450 3A4)		 1xje RIBONUCLEOTIDE
REDUCTASE,
B12-DEPENDENT
(Thermotoga
maritima) 		5 / 11 LEU A 357
ILE A 423
ALA A 427
GLU A 324
LEU A 365
 None
None
None
GDP  A1002 (-2.6A)
None
 1.37A 2v0mA-1xjeA:
undetectable		 2v0mA-1xjeA:
23.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VIN_A_505A1247_1
(UROKINASE-TYPE
PLASMINOGEN
ACTIVATOR CHAIN B)		 1zca G ALPHA I/12
(Mus
musculus) 		4 / 8 SER A  66
SER A  69
GLY A 228
GLY A  62
 GDP  A 382 (-2.9A)
MG  A 383 ( 2.1A)
ALF  A 384 (-3.3A)
None
 0.71A 2vinA-1zcaA:
undetectable		 2vinA-1zcaA:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VIN_A_505A1247_1
(UROKINASE-TYPE
PLASMINOGEN
ACTIVATOR CHAIN B)		 2ik8 GUANINE
NUCLEOTIDE-BINDING
PROTEIN G(I),
ALPHA-1 SUBUNIT
(Homo
sapiens) 		4 / 8 SER A  44
SER A  47
GLY A 203
GLY A  40
 GDP  A 401 (-3.6A)
MG  A 356 ( 1.9A)
ALF  A 355 (-3.3A)
None
 0.76A 2vinA-2ik8A:
undetectable		 2vinA-2ik8A:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VIN_A_505A1247_1
(UROKINASE-TYPE
PLASMINOGEN
ACTIVATOR CHAIN B)		 3cx6 GUANINE
NUCLEOTIDE-BINDING
PROTEIN ALPHA-13
SUBUNIT
(Mus
musculus) 		4 / 8 SER A  59
SER A  62
GLY A 225
GLY A  55
 GDP  A 775 (-3.4A)
MG  A 675 ( 2.7A)
None
None
 0.70A 2vinA-3cx6A:
undetectable		 2vinA-3cx6A:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VIN_A_505A1247_1
(UROKINASE-TYPE
PLASMINOGEN
ACTIVATOR CHAIN B)		 3cx6 GUANINE
NUCLEOTIDE-BINDING
PROTEIN ALPHA-13
SUBUNIT
(Mus
musculus) 		5 / 8 SER A 268
SER A 248
VAL A 247
GLY A  57
GLY A  55
 None
None
None
GDP  A 775 ( 4.2A)
None
 1.21A 2vinA-3cx6A:
undetectable		 2vinA-3cx6A:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W3M_B_FOLB1188_0
(DIHYDROFOLATE
REDUCTASE)		 3wya ELONGATION FACTOR
1-ALPHA
(Pyrococcus
horikoshii) 		5 / 12 ILE A 139
ALA A 109
LEU A 207
PHE A  12
ASN A 144
 None
None
None
None
GDP  A 500 (-3.0A)
 1.19A 2w3mB-3wyaA:
undetectable		 2w3mB-3wyaA:
18.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WA2_B_SAMB1267_1
(NON-STRUCTURAL
PROTEIN 5)		 3p27 ELONGATION FACTOR 1
ALPHA-LIKE PROTEIN
(Saccharomyces
cerevisiae) 		3 / 3 SER A 352
HIS A 175
ASP A 288
 GDP  A 663 (-2.6A)
None
None
 0.80A 2wa2B-3p27A:
undetectable		 2wa2B-3p27A:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X0Y_A_X0TA1625_1
(O-GLCNACASE NAGJ)		 3c7k GUANINE
NUCLEOTIDE-BINDING
PROTEIN G(O) SUBUNIT
ALPHA
(Mus
musculus) 		5 / 12 LYS A  51
TYR A  69
VAL A  72
VAL A 186
ASP A 201
 GDP  A 361 ( 4.5A)
None
None
None
MG  A 362 ( 4.5A)
 1.41A 2x0yA-3c7kA:
3.2		 2x0yA-3c7kA:
19.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_A_QPSA1060_1
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		 1xje RIBONUCLEOTIDE
REDUCTASE,
B12-DEPENDENT
(Thermotoga
maritima) 		5 / 12 THR A 157
SER A 318
THR A 319
ASN A 320
GLY A 161
 None
None
None
GDP  A1002 (-3.7A)
GDP  A1002 (-4.4A)
 1.23A 2x2iA-1xjeA:
2.0		 2x2iA-1xjeA:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XCT_X_CPFX1020_1
(DNA GYRASE SUBUNIT
B, DNA GYRASE
SUBUNIT A)		 5igp MACROLIDE
2'-PHOSPHOTRANSFERAS
E
(Escherichia
coli) 		4 / 4 ARG A  37
GLY A  33
GLU A  31
SER A 221
 None
None
None
GDP  A 401 ( 4.7A)
 1.20A 2xctS-5igpA:
undetectable
2xctU-5igpA:
undetectable		 2xctS-5igpA:
19.85
2xctU-5igpA:
19.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XF3_A_J01A600_1
(ORF12)		 3r4v PUTATIVE
UNCHARACTERIZED
PROTEIN
(Pseudomonas
phage
201phi2-1) 		5 / 11 SER A  94
THR A  50
ALA A  10
GLY A  11
MET A  15
 GDP  A 400 (-3.8A)
None
None
GDP  A 400 (-3.4A)
None
 1.22A 2xf3A-3r4vA:
undetectable		 2xf3A-3r4vA:
19.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XF3_B_J01B600_1
(ORF12)		 3r4v PUTATIVE
UNCHARACTERIZED
PROTEIN
(Pseudomonas
phage
201phi2-1) 		5 / 11 SER A  94
THR A  50
ALA A  10
GLY A  11
MET A  15
 GDP  A 400 (-3.8A)
None
None
GDP  A 400 (-3.4A)
None
 1.22A 2xf3B-3r4vA:
undetectable		 2xf3B-3r4vA:
19.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XH9_A_J01A1437_1
(ORF12)		 3r4v PUTATIVE
UNCHARACTERIZED
PROTEIN
(Pseudomonas
phage
201phi2-1) 		5 / 11 SER A  94
THR A  50
ALA A  10
GLY A  11
MET A  15
 GDP  A 400 (-3.8A)
None
None
GDP  A 400 (-3.4A)
None
 1.22A 2xh9A-3r4vA:
undetectable		 2xh9A-3r4vA:
19.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y00_B_Y00B601_2
(BETA-1 ADRENERGIC
RECEPTOR)		 5uzh NAFOA.00085.B
(Naegleria
fowleri) 		3 / 3 VAL A 123
ASN A 217
TRP A 258
 GDP  A 401 (-4.1A)
GDP  A 401 ( 3.4A)
None
 1.10A 2y00B-5uzhA:
undetectable		 2y00B-5uzhA:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y05_A_RALA801_1
(PROSTAGLANDIN
REDUCTASE 1)		 4n9w GDP-MANNOSE-DEPENDEN
T
ALPHA-(1-2)-PHOSPHAT
IDYLINOSITOL
MANNOSYLTRANSFERASE
(Mycolicibacteriu
m
smegmatis) 		4 / 8 VAL A 344
SER A 275
VAL A 290
VAL A 301
 None
GDP  A 401 (-3.5A)
None
None
 1.14A 2y05A-4n9wA:
6.0
2y05B-4n9wA:
6.2		 2y05A-4n9wA:
22.54
2y05B-4n9wA:
22.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y05_A_RALA802_1
(PROSTAGLANDIN
REDUCTASE 1)		 1rpn GDP-MANNOSE
4,6-DEHYDRATASE
(Pseudomonas
aeruginosa) 		4 / 7 ASN A 213
GLY A 212
VAL A 190
ASP A 274
 None
GDP  A1601 (-3.3A)
GDP  A1601 (-3.7A)
None
 0.90A 2y05A-1rpnA:
5.3
2y05B-1rpnA:
5.6		 2y05A-1rpnA:
21.98
2y05B-1rpnA:
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7H_B_SAMB530_0
(TYPE I RESTRICTION
ENZYME ECOKI M
PROTEIN)		 3j4s FTSZ/TUBULIN-RELATED
PROTEIN
(Bacillus
thuringiensis) 		5 / 12 ALA A 137
GLY A 139
GLY A  31
LEU A 180
PRO A 169
 None
GDP  A 900 (-3.0A)
GDP  A 900 (-3.6A)
None
GDP  A 900 ( 4.7A)
 0.90A 2y7hB-3j4sA:
undetectable		 2y7hB-3j4sA:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7H_B_SAMB530_0
(TYPE I RESTRICTION
ENZYME ECOKI M
PROTEIN)		 4xcq TUBZ
(Clostridium
phage
c-st) 		5 / 12 ILE A  76
ALA A  94
GLY A 101
THR A 100
LEU A 162
 None
None
GDP  A 401 (-3.3A)
GDP  A 401 (-3.4A)
None
 1.07A 2y7hB-4xcqA:
2.4		 2y7hB-4xcqA:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7H_C_SAMC530_0
(TYPE I RESTRICTION
ENZYME ECOKI M
PROTEIN)		 3j4s FTSZ/TUBULIN-RELATED
PROTEIN
(Bacillus
thuringiensis) 		5 / 12 ALA A 137
GLY A 139
GLY A  31
LEU A 180
PRO A 169
 None
GDP  A 900 (-3.0A)
GDP  A 900 (-3.6A)
None
GDP  A 900 ( 4.7A)
 0.90A 2y7hC-3j4sA:
2.2		 2y7hC-3j4sA:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7H_C_SAMC530_0
(TYPE I RESTRICTION
ENZYME ECOKI M
PROTEIN)		 4xcq TUBZ
(Clostridium
phage
c-st) 		5 / 12 ILE A  76
ALA A  94
GLY A 101
THR A 100
LEU A 162
 None
None
GDP  A 401 (-3.3A)
GDP  A 401 (-3.4A)
None
 1.06A 2y7hC-4xcqA:
undetectable		 2y7hC-4xcqA:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YFB_A_ACTA501_0
(METHYL-ACCEPTING
CHEMOTAXIS
TRANSDUCER)		 5igp MACROLIDE
2'-PHOSPHOTRANSFERAS
E
(Escherichia
coli) 		4 / 7 ASP A 219
VAL A  50
ARG A  52
ILE A  38
 GDP  A 401 (-2.6A)
GDP  A 401 (-4.6A)
GDP  A 401 (-4.5A)
GDP  A 401 (-4.2A)
 0.95A 2yfbA-5igpA:
undetectable		 2yfbA-5igpA:
23.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YFB_B_ACTB501_0
(METHYL-ACCEPTING
CHEMOTAXIS
TRANSDUCER)		 5igp MACROLIDE
2'-PHOSPHOTRANSFERAS
E
(Escherichia
coli) 		4 / 6 ASP A 219
VAL A  50
ARG A  52
ILE A  38
 GDP  A 401 (-2.6A)
GDP  A 401 (-4.6A)
GDP  A 401 (-4.5A)
GDP  A 401 (-4.2A)
 0.98A 2yfbB-5igpA:
undetectable		 2yfbB-5igpA:
23.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Z0Y_A_SAMA300_0
(PUTATIVE
UNCHARACTERIZED
PROTEIN TTHA0657)		 1ofu CELL DIVISION
PROTEIN FTSZ
(Pseudomonas
aeruginosa) 		5 / 9 ALA A 113
GLY A  20
GLY A  23
ILE A  41
LEU A  59
 None
GDP  A1318 (-3.5A)
None
None
None
 0.91A 2z0yA-1ofuA:
3.4		 2z0yA-1ofuA:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZS9_A_PAUA603_0
(PANTOTHENATE KINASE)		 1d2e ELONGATION FACTOR TU
(EF-TU)
(Bos
taurus) 		4 / 6 VAL A 150
ASP A 126
HIS A 124
ASN A 181
 None
MG  A 501 ( 3.9A)
None
GDP  A1301 (-3.1A)
 1.21A 2zs9A-1d2eA:
0.6		 2zs9A-1d2eA:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZS9_A_PAUA603_0
(PANTOTHENATE KINASE)		 5w7q CONSENSUS ELONGATION
FACTOR
(synthetic
construct) 		4 / 6 VAL A 105
ASP A  81
HIS A  79
ASN A 136
 None
GDP  A 402 ( 4.8A)
None
GDP  A 402 (-2.9A)
 1.14A 2zs9A-5w7qA:
undetectable		 2zs9A-5w7qA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZUL_A_SAMA376_0
(PROBABLE RIBOSOMAL
RNA SMALL SUBUNIT
METHYLTRANSFERASE)		 4b46 CELL DIVISION
PROTEIN FTSZ
(Haloferax
volcanii) 		5 / 12 GLY A 106
GLY A 108
ALA A  70
VAL A 104
VAL A  15
 GDP  A1368 (-3.6A)
GDP  A1368 ( 3.8A)
None
None
None
 1.04A 2zulA-4b46A:
3.5		 2zulA-4b46A:
23.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZZN_B_SAMB402_0
(UNCHARACTERIZED
PROTEIN MJ0883)		 5mjs TUBULIN BETA CHAIN
(Schizosaccharomy
ces
pombe) 		5 / 12 GLY A 140
PRO A 171
ILE A 100
ASN A  99
PHE A 407
 GDP  A 500 (-3.6A)
None
None
None
None
 1.34A 2zznB-5mjsA:
undetectable		 2zznB-5mjsA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AOB_C_RFPC2002_1
(ACRIFLAVINE
RESISTANCE PROTEIN B)		 4tz0 ATP-DEPENDENT RNA
HELICASE MSS116,
MITOCHONDRIAL
(Saccharomyces
cerevisiae) 		5 / 12 GLN A 134
PHE A 160
ALA A 161
THR A 130
LEU A 141
 None
GDP  A 601 (-4.1A)
None
GDP  A 601 (-3.6A)
None
 1.18A 3aobC-4tz0A:
undetectable		 3aobC-4tz0A:
19.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AOC_C_ERYC3402_1
(ACRIFLAVINE
RESISTANCE PROTEIN B)		 2yv5 YJEQ PROTEIN
(Aquifex
aeolicus) 		3 / 3 THR A  88
SER A 174
LYS A 228
 None
GDP  A1001 ( 4.1A)
None
 1.14A 3aocC-2yv5A:
undetectable		 3aocC-2yv5A:
14.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B9M_A_SALA1100_1
(SERUM ALBUMIN)		 1yzg ADP-RIBOSYLATION
FACTOR-LIKE 8
(Homo
sapiens) 		4 / 4 LEU A  89
ARG A  98
LEU A  99
ALA A  27
 None
None
None
GDP  A 181 (-4.0A)
 1.21A 3b9mA-1yzgA:
undetectable		 3b9mA-1yzgA:
13.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BC9_A_ACRA901_1
(ALPHA AMYLASE,
CATALYTIC REGION)		 2fv8 RHO-RELATED
GTP-BINDING PROTEIN
RHOB
(Homo
sapiens) 		4 / 7 ASP A  87
SER A  85
GLU A  64
ASP A  65
 None
None
GDP  A 201 ( 4.8A)
None
 1.09A 3bc9A-2fv8A:
undetectable		 3bc9A-2fv8A:
15.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BEX_C_PAUC248_0
(TYPE III
PANTOTHENATE KINASE)		 1u0l PROBABLE GTPASE ENGC
(Thermotoga
maritima) 		5 / 11 ASN A 117
VAL A  85
ILE A 183
THR A 146
LEU A 157
 GDP  A 299 (-3.1A)
None
None
None
None
 1.37A 3bexC-1u0lA:
1.4
3bexD-1u0lA:
undetectable		 3bexC-1u0lA:
25.08
3bexD-1u0lA:
25.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BEX_F_PAUF248_0
(TYPE III
PANTOTHENATE KINASE)		 1u0l PROBABLE GTPASE ENGC
(Thermotoga
maritima) 		5 / 11 THR A 146
LEU A 157
ASN A 117
VAL A  85
ILE A 183
 None
None
GDP  A 299 (-3.1A)
None
None
 1.36A 3bexE-1u0lA:
undetectable
3bexF-1u0lA:
1.6		 3bexE-1u0lA:
25.08
3bexF-1u0lA:
25.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BEX_F_PAUF248_0
(TYPE III
PANTOTHENATE KINASE)		 3ec1 YQEH GTPASE
(Geobacillus
stearothermophil
us) 		5 / 11 THR A 177
ASN A 180
GLY A 221
ASP A 218
ILE A  78
 GDP  A 900 (-3.8A)
None
GDP  A 900 ( 4.9A)
None
None
 1.24A 3bexE-3ec1A:
undetectable
3bexF-3ec1A:
undetectable		 3bexE-3ec1A:
23.24
3bexF-3ec1A:
23.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BEX_F_PAUF248_0
(TYPE III
PANTOTHENATE KINASE)		 4m8n PLEXINC1
INTRACELLULAR REGION
RAS-RELATED PROTEIN
RAP-1B
(Danio
rerio;
Homo
sapiens) 		5 / 11 LYS E  16
THR E  35
ASN E 116
GLY E  12
ARG A 711
 AF3  E 202 ( 3.1A)
MG  E 200 (-2.7A)
GDP  E 201 (-3.2A)
AF3  E 202 (-3.5A)
GDP  E 201 ( 2.9A)
 1.40A 3bexE-4m8nE:
undetectable
3bexF-4m8nE:
undetectable		 3bexE-4m8nE:
21.59
3bexF-4m8nE:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BF1_A_PAUA248_0
(TYPE III
PANTOTHENATE KINASE)		 1u0l PROBABLE GTPASE ENGC
(Thermotoga
maritima) 		5 / 11 ASN A 117
VAL A  85
ILE A 183
THR A 146
LEU A 157
 GDP  A 299 (-3.1A)
None
None
None
None
 1.38A 3bf1A-1u0lA:
undetectable
3bf1B-1u0lA:
undetectable		 3bf1A-1u0lA:
25.08
3bf1B-1u0lA:
25.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BF1_B_PAUB248_0
(TYPE III
PANTOTHENATE KINASE)		 3ec1 YQEH GTPASE
(Geobacillus
stearothermophil
us) 		5 / 12 THR A 177
ASN A 180
GLY A 221
ASP A 218
ILE A  78
 GDP  A 900 (-3.8A)
None
GDP  A 900 ( 4.9A)
None
None
 1.25A 3bf1A-3ec1A:
undetectable
3bf1B-3ec1A:
undetectable		 3bf1A-3ec1A:
23.24
3bf1B-3ec1A:
23.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BF1_C_PAUC248_0
(TYPE III
PANTOTHENATE KINASE)		 1u0l PROBABLE GTPASE ENGC
(Thermotoga
maritima) 		5 / 11 ASN A 117
VAL A  85
ILE A 183
THR A 146
LEU A 157
 GDP  A 299 (-3.1A)
None
None
None
None
 1.34A 3bf1C-1u0lA:
1.6
3bf1D-1u0lA:
undetectable		 3bf1C-1u0lA:
25.08
3bf1D-1u0lA:
25.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BF1_D_PAUD248_0
(TYPE III
PANTOTHENATE KINASE)		 1u0l PROBABLE GTPASE ENGC
(Thermotoga
maritima) 		5 / 11 THR A 146
LEU A 157
ASN A 117
VAL A  85
ILE A 183
 None
None
GDP  A 299 (-3.1A)
None
None
 1.38A 3bf1C-1u0lA:
1.6
3bf1D-1u0lA:
undetectable		 3bf1C-1u0lA:
25.08
3bf1D-1u0lA:
25.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BF1_E_PAUE248_0
(TYPE III
PANTOTHENATE KINASE)		 1u0l PROBABLE GTPASE ENGC
(Thermotoga
maritima) 		5 / 11 ASN A 117
VAL A  85
ILE A 183
THR A 146
LEU A 157
 GDP  A 299 (-3.1A)
None
None
None
None
 1.36A 3bf1E-1u0lA:
undetectable
3bf1F-1u0lA:
undetectable		 3bf1E-1u0lA:
25.08
3bf1F-1u0lA:
25.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BF1_E_PAUE248_0
(TYPE III
PANTOTHENATE KINASE)		 3ec1 YQEH GTPASE
(Geobacillus
stearothermophil
us) 		5 / 11 ASN A 180
GLY A 221
ASP A 218
ILE A  78
THR A 177
 None
GDP  A 900 ( 4.9A)
None
None
GDP  A 900 (-3.8A)
 1.24A 3bf1E-3ec1A:
undetectable
3bf1F-3ec1A:
undetectable		 3bf1E-3ec1A:
23.24
3bf1F-3ec1A:
23.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BF1_F_PAUF248_0
(TYPE III
PANTOTHENATE KINASE)		 1u0l PROBABLE GTPASE ENGC
(Thermotoga
maritima) 		5 / 11 THR A 146
LEU A 157
ASN A 117
VAL A  85
ILE A 183
 None
None
GDP  A 299 (-3.1A)
None
None
 1.37A 3bf1E-1u0lA:
undetectable
3bf1F-1u0lA:
undetectable		 3bf1E-1u0lA:
25.08
3bf1F-1u0lA:
25.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BRF_A_SORA1_0
(LIN-12 AND GLP-1
PHENOTYPE PROTEIN 1,
ISOFORM A)		 3zbq PHIKZ039
(Pseudomonas
virus
phiKZ) 		3 / 3 GLY A  14
ASP A  34
SER A  36
 GDP  A 999 (-3.3A)
GDP  A 999 ( 4.4A)
None
 0.59A 3brfA-3zbqA:
undetectable		 3brfA-3zbqA:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BUF_A_AEGA394_0
(BETA-SECRETASE 1)		 5dn8 GTPASE DER
(Coxiella
burnetii) 		4 / 5 ASP A  56
ILE A 103
ILE A   7
GLY A  58
 GDP  A 502 ( 4.7A)
None
None
None
 0.80A 3bufA-5dn8A:
undetectable		 3bufA-5dn8A:
24.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CCF_A_BEZA261_0
(CYCLOPROPANE-FATTY-A
CYL-PHOSPHOLIPID
SYNTHASE)		 4b8w GDP-L-FUCOSE
SYNTHASE
(Homo
sapiens) 		4 / 8 HIS A 186
GLY A  75
ASN A  79
TYR A 143
 NAP  A 900 ( 3.4A)
GDP  A 901 (-3.1A)
None
None
 1.39A 3ccfA-4b8wA:
3.0		 3ccfA-4b8wA:
24.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CKK_A_SAMA301_0
(TRNA
(GUANINE-N(7)-)-METH
YLTRANSFERASE)		 3r4v PUTATIVE
UNCHARACTERIZED
PROTEIN
(Pseudomonas
phage
201phi2-1) 		5 / 12 GLU A 167
ILE A 164
ASN A 165
LEU A 211
GLU A 210
 None
GDP  A 400 (-3.7A)
GDP  A 400 (-2.9A)
None
None
 1.17A 3ckkA-3r4vA:
3.8		 3ckkA-3r4vA:
19.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CLB_C_TMQC613_1
(DHFR-TS)		 5mlz DOLICHOL
MONOPHOSPHATE
MANNOSE SYNTHASE
(Pyrococcus
furiosus) 		5 / 12 ALA A  72
ILE A  61
ASP A  39
LEU A  16
ILE A   7
 GDP  A 401 (-3.4A)
None
GDP  A 401 (-3.1A)
None
None
 1.06A 3clbC-5mlzA:
undetectable		 3clbC-5mlzA:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D41_A_FCNA4001_1
(FOMA PROTEIN)		 3zid TUBULIN/FTSZ, GTPASE
(Methanothrix
thermoacetophila) 		4 / 8 GLY A 115
GLY A  10
ILE A  48
SER A 119
 GDP  A 999 (-3.7A)
GDP  A 999 (-3.5A)
None
None
 0.68A 3d41A-3zidA:
2.6		 3d41A-3zidA:
23.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DMF_A_SAMA388_0
(PROBABLE RIBOSOMAL
RNA SMALL SUBUNIT
METHYLTRANSFERASE)		 4b46 CELL DIVISION
PROTEIN FTSZ
(Haloferax
volcanii) 		5 / 12 GLY A 106
GLY A 108
ALA A  70
VAL A 104
VAL A  15
 GDP  A1368 (-3.6A)
GDP  A1368 ( 3.8A)
None
None
None
 1.02A 3dmfA-4b46A:
3.8		 3dmfA-4b46A:
23.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DMH_A_SAMA384_0
(PROBABLE RIBOSOMAL
RNA SMALL SUBUNIT
METHYLTRANSFERASE)		 4b46 CELL DIVISION
PROTEIN FTSZ
(Haloferax
volcanii) 		5 / 12 GLY A 106
GLY A 108
ALA A  70
VAL A 104
VAL A  15
 GDP  A1368 (-3.6A)
GDP  A1368 ( 3.8A)
None
None
None
 1.02A 3dmhA-4b46A:
2.6		 3dmhA-4b46A:
23.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DOU_A_SAMA1_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE J)		 2r6r CELL DIVISION
PROTEIN FTSZ
(Aquifex
aeolicus) 		5 / 12 PRO 1  71
GLY 1 104
GLY 1 103
LEU 1  79
ILE 1  85
 None
GDP  1 339 (-3.4A)
GDP  1 339 (-3.6A)
None
None
 0.97A 3douA-2r6r1:
3.7		 3douA-2r6r1:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DOU_A_SAMA1_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE J)		 2vaw CELL DIVISION
PROTEIN FTSZ
(Pseudomonas
aeruginosa) 		5 / 12 PRO A  75
GLY A 108
GLY A 107
LEU A  83
ILE A  89
 None
GDP  A1317 (-3.4A)
GDP  A1317 (-3.5A)
None
None
 0.87A 3douA-2vawA:
4.4		 3douA-2vawA:
18.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EEO_A_SAMA328_0
(MODIFICATION
METHYLASE HHAI)		 5h7k ELONGATION FACTOR 2
(Pyrococcus
horikoshii) 		5 / 12 PHE A 205
GLY A 127
ASP A 154
LEU A 214
ASN A 151
 None
None
GDP  A 501 (-2.8A)
None
GDP  A 501 (-3.3A)
 1.13A 3eeoA-5h7kA:
4.3		 3eeoA-5h7kA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EEY_A_SAMA300_0
(PUTATIVE RRNA
METHYLASE)		 4xcq TUBZ
(Clostridium
phage
c-st) 		5 / 12 GLY A  15
ASN A  16
ASN A 174
ILE A  33
THR A 105
 None
GDP  A 401 (-3.9A)
GDP  A 401 (-2.8A)
None
None
 0.94A 3eeyA-4xcqA:
5.1		 3eeyA-4xcqA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EEY_B_SAMB300_0
(PUTATIVE RRNA
METHYLASE)		 4xcq TUBZ
(Clostridium
phage
c-st) 		5 / 12 GLY A  15
ASN A  16
ASN A 174
ILE A  33
THR A 105
 None
GDP  A 401 (-3.9A)
GDP  A 401 (-2.8A)
None
None
 0.93A 3eeyB-4xcqA:
undetectable		 3eeyB-4xcqA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EEY_H_SAMH300_0
(PUTATIVE RRNA
METHYLASE)		 4xcq TUBZ
(Clostridium
phage
c-st) 		5 / 12 GLY A  15
ASN A  16
ASN A 174
ILE A  33
THR A 105
 None
GDP  A 401 (-3.9A)
GDP  A 401 (-2.8A)
None
None
 0.92A 3eeyH-4xcqA:
4.3		 3eeyH-4xcqA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EEY_I_SAMI300_0
(PUTATIVE RRNA
METHYLASE)		 4xcq TUBZ
(Clostridium
phage
c-st) 		5 / 12 GLY A  15
ASN A  16
ASN A 174
ILE A  33
THR A 105
 None
GDP  A 401 (-3.9A)
GDP  A 401 (-2.8A)
None
None
 0.94A 3eeyI-4xcqA:
5.3		 3eeyI-4xcqA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EL9_A_DR7A100_2
(PROTEASE)		 1ofu CELL DIVISION
PROTEIN FTSZ
(Pseudomonas
aeruginosa) 		5 / 10 GLY A 192
ALA A 193
GLY A 227
PRO A 165
THR A 133
 None
None
None
None
GDP  A1318 ( 4.9A)
 0.92A 3el9B-1ofuA:
undetectable		 3el9B-1ofuA:
13.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ELU_A_SAMA4633_0
(METHYLTRANSFERASE)		 4xcq TUBZ
(Clostridium
phage
c-st) 		5 / 12 GLY A  57
GLY A 101
GLY A  59
THR A  95
ILE A  10
 None
GDP  A 401 (-3.3A)
None
GDP  A 401 (-3.0A)
None
 0.84A 3eluA-4xcqA:
undetectable		 3eluA-4xcqA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EM0_B_CHDB153_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 5mjs TUBULIN BETA CHAIN
(Schizosaccharomy
ces
pombe) 		4 / 7 ILE A 100
PHE A 384
TYR A 183
GLY A 141
 None
None
None
GDP  A 500 (-3.1A)
 0.98A 3em0B-5mjsA:
undetectable		 3em0B-5mjsA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EMB_A_SAMA4633_0
(METHYLTRANSFERASE)		 4xcq TUBZ
(Clostridium
phage
c-st) 		5 / 12 GLY A  57
GLY A 101
GLY A  59
THR A  95
ILE A  10
 None
GDP  A 401 (-3.3A)
None
GDP  A 401 (-3.0A)
None
 0.83A 3embA-4xcqA:
2.9		 3embA-4xcqA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FZG_A_SAMA300_0
(16S RRNA METHYLASE)		 5h7k ELONGATION FACTOR 2
(Pyrococcus
horikoshii) 		5 / 12 THR A  39
PHE A 205
GLY A 206
ILE A 229
VAL A 250
 GDP  A 501 (-3.5A)
None
None
None
None
 0.99A 3fzgA-5h7kA:
undetectable		 3fzgA-5h7kA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G88_B_SAMB303_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE G)		 1ofu CELL DIVISION
PROTEIN FTSZ
(Pseudomonas
aeruginosa) 		5 / 11 GLY A  20
GLY A  22
THR A 102
ALA A 113
ALA A  49
 GDP  A1318 (-3.5A)
GDP  A1318 (-3.4A)
None
None
None
 1.10A 3g88B-1ofuA:
3.8		 3g88B-1ofuA:
24.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G89_A_SAMA303_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE G)		 1ofu CELL DIVISION
PROTEIN FTSZ
(Pseudomonas
aeruginosa) 		5 / 12 GLY A  20
GLY A  22
THR A 102
ALA A 113
ALA A  49
 GDP  A1318 (-3.5A)
GDP  A1318 (-3.4A)
None
None
None
 1.08A 3g89A-1ofuA:
3.9		 3g89A-1ofuA:
24.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G89_B_SAMB303_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE G)		 1ofu CELL DIVISION
PROTEIN FTSZ
(Pseudomonas
aeruginosa) 		5 / 11 GLY A  20
GLY A  22
THR A 102
ALA A 113
ALA A  49
 GDP  A1318 (-3.5A)
GDP  A1318 (-3.4A)
None
None
None
 1.09A 3g89B-1ofuA:
3.9		 3g89B-1ofuA:
24.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G8B_A_SAMA303_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE G)		 1ofu CELL DIVISION
PROTEIN FTSZ
(Pseudomonas
aeruginosa) 		5 / 12 GLY A  20
GLY A  22
THR A 102
ALA A 113
ALA A  49
 GDP  A1318 (-3.5A)
GDP  A1318 (-3.4A)
None
None
None
 1.05A 3g8bA-1ofuA:
1.2		 3g8bA-1ofuA:
24.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G8B_A_SAMA303_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE G)		 2vaw CELL DIVISION
PROTEIN FTSZ
(Pseudomonas
aeruginosa) 		5 / 12 GLY A  20
GLY A  22
THR A 102
ALA A 113
ALA A  49
 GDP  A1317 (-3.4A)
GDP  A1317 (-3.3A)
None
None
None
 1.08A 3g8bA-2vawA:
3.7		 3g8bA-2vawA:
22.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G8B_A_SAMA303_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE G)		 3wgk CELL DIVISION
PROTEIN FTSZ
(Staphylococcus
aureus) 		5 / 12 GLY A  20
GLY A  22
THR A 102
ALA A 113
ALA A  49
 GDP  A 400 (-3.5A)
GDP  A 400 (-3.4A)
None
None
None
 1.09A 3g8bA-3wgkA:
3.7		 3g8bA-3wgkA:
23.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G8B_B_SAMB303_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE G)		 1ofu CELL DIVISION
PROTEIN FTSZ
(Pseudomonas
aeruginosa) 		5 / 12 GLY A  20
GLY A  22
THR A 102
ALA A 113
ALA A  49
 GDP  A1318 (-3.5A)
GDP  A1318 (-3.4A)
None
None
None
 1.06A 3g8bB-1ofuA:
3.3		 3g8bB-1ofuA:
24.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GCZ_A_SAMA4633_0
(POLYPROTEIN)		 4xcq TUBZ
(Clostridium
phage
c-st) 		5 / 12 GLY A  57
GLY A 101
GLY A  59
THR A  95
ILE A  10
 None
GDP  A 401 (-3.3A)
None
GDP  A 401 (-3.0A)
None
 0.84A 3gczA-4xcqA:
3.9		 3gczA-4xcqA:
23.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GWS_X_T3X500_1
(THYROID HORMONE
RECEPTOR BETA)		 2rhd SMALL GTP BINDING
PROTEIN RAB1A
(Cryptosporidium
parvum) 		5 / 12 ILE A  86
ALA A 162
ALA A 153
LEU A  25
PHE A 148
 None
None
GDP  A3800 (-3.7A)
None
None
 1.05A 3gwsX-2rhdA:
undetectable		 3gwsX-2rhdA:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GWW_A_SFXA801_1
(TRANSPORTER)		 5dn8 GTPASE DER
(Coxiella
burnetii) 		5 / 12 LEU A 191
GLY A 187
ILE A 326
ALA A 267
ASP A 297
 None
GDP  A 501 (-3.4A)
None
None
GDP  A 501 (-2.9A)
 1.08A 3gwwA-5dn8A:
undetectable		 3gwwA-5dn8A:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GYQ_B_SAMB270_0
(RRNA
(ADENOSINE-2'-O-)-ME
THYLTRANSFERASE)		 1z6y ADP-RIBOSYLATION
FACTOR-LIKE PROTEIN
5
(Homo
sapiens) 		5 / 11 LEU A  24
GLY A  28
ILE A  99
SER A  93
VAL A  90
 None
GDP  A 180 (-3.2A)
None
None
None
 1.18A 3gyqB-1z6yA:
undetectable		 3gyqB-1z6yA:
20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IA4_D_MTXD164_2
(DIHYDROFOLATE
REDUCTASE)		 5vys GDP-MANNOSE
4,6-DEHYDRATASE /
GDP-4-AMINO-4,6-DIDE
OXY-D-MANNOSE
FORMYLTRANSFERASE
(Brucella
melitensis) 		3 / 3 ARG A  88
ILE A 169
THR A 131
 GDP  A 303 (-3.0A)
None
None
 0.67A 3ia4D-5vysA:
undetectable		 3ia4D-5vysA:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IJX_H_HCZH800_1
(GLUTAMATE RECEPTOR 2)		 1xje RIBONUCLEOTIDE
REDUCTASE,
B12-DEPENDENT
(Thermotoga
maritima) 		4 / 5 PRO A 490
SER A 502
LEU A 335
SER A 337
 GDP  A1002 (-3.9A)
None
None
None
 1.29A 3ijxH-1xjeA:
undetectable		 3ijxH-1xjeA:
18.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IV6_B_SAMB301_0
(PUTATIVE
ZN-DEPENDENT ALCOHOL
DEHYDROGENASE)		 5vcu RAS-RELATED C3
BOTULINUM TOXIN
SUBSTRATE 1 ISOFORM
X2
(Naegleria
fowleri) 		5 / 12 PHE A  28
THR A 161
PHE A 169
ILE A 155
ASP A 118
 GDP  A 301 (-4.5A)
None
None
None
GDP  A 301 (-2.9A)
 1.13A 3iv6B-5vcuA:
undetectable		 3iv6B-5vcuA:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IXL_A_PACA5000_0
(ARYLMALONATE
DECARBOXYLASE)		 5mjs TUBULIN BETA CHAIN
(Schizosaccharomy
ces
pombe) 		5 / 10 PRO A 171
SER A 188
VAL A 169
SER A 145
GLY A 141
 None
None
GDP  A 500 ( 4.9A)
GDP  A 500 ( 4.6A)
GDP  A 500 (-3.1A)
 1.46A 3ixlA-5mjsA:
1.4		 3ixlA-5mjsA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JAY_A_SAMA1102_0
(STRUCTURAL PROTEIN
VP3)		 5hci GPN-LOOP GTPASE 1
(Saccharomyces
cerevisiae) 		5 / 12 GLY A 109
ALA A  12
PRO A  41
ALA A  42
ILE A 111
 GDP  A 301 ( 4.4A)
GDP  A 301 ( 4.8A)
None
None
None
 0.93A 3jayA-5hciA:
undetectable		 3jayA-5hciA:
12.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JB2_A_SAMA1101_0
(STRUCTURAL PROTEIN
VP3)		 4mde METALLOPHOSPHOESTERA
SE
(Ruminiclostridiu
m
thermocellum) 		5 / 12 ASN A 107
GLY A  18
VAL A 125
ILE A 130
GLU A 127
 None
GDP  A1001 (-3.8A)
None
None
None
 1.38A 3jb2A-4mdeA:
2.3		 3jb2A-4mdeA:
11.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JB2_A_SAMA1101_1
(STRUCTURAL PROTEIN
VP3)		 3ufx SUCCINYL-COA
SYNTHETASE BETA
SUBUNIT
(Thermus
aquaticus) 		3 / 3 GLU B 188
ASP B 204
ASP B 124
 None
GDP  B 398 ( 3.5A)
None
 0.59A 3jb2A-3ufxB:
undetectable		 3jb2A-3ufxB:
15.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JX1_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 4oro POLYMERASE PB2
(Influenza
B
virus) 		4 / 8 PHE A 365
SER A 407
ARG A 334
TRP A 359
 None
None
GDP  A 501 (-4.1A)
GDP  A 501 (-3.3A)
 1.19A 3jx1A-4oroA:
undetectable
3jx1B-4oroA:
undetectable		 3jx1A-4oroA:
18.21
3jx1B-4oroA:
18.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K13_B_THHB643_0
(5-METHYLTETRAHYDROFO
LATE-HOMOCYSTEINE
METHYLTRANSFERASE)		 5w3j TUBULIN BETA CHAIN
(Saccharomyces
cerevisiae) 		5 / 12 GLU B 108
GLY B  98
VAL B 116
GLY B  93
SER B  95
 None
GDP  B 501 (-4.4A)
None
None
None
 1.06A 3k13B-5w3jB:
2.4		 3k13B-5w3jB:
22.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K13_C_THHC643_0
(5-METHYLTETRAHYDROFO
LATE-HOMOCYSTEINE
METHYLTRANSFERASE)		 5w3j TUBULIN BETA CHAIN
(Saccharomyces
cerevisiae) 		5 / 12 GLU B 108
GLY B  98
VAL B 116
GLY B  93
SER B  95
 None
GDP  B 501 (-4.4A)
None
None
None
 1.05A 3k13C-5w3jB:
2.4		 3k13C-5w3jB:
22.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K5V_A_STIA2_2
(TYROSINE-PROTEIN
KINASE ABL1)		 4v0k ARF-LIKE SMALL
GTPASE
(Chlamydomonas
reinhardtii) 		4 / 6 LEU A 163
VAL A  20
VAL A  93
ILE A  34
 GDP  A 700 (-4.4A)
None
None
None
 0.87A 3k5vA-4v0kA:
undetectable		 3k5vA-4v0kA:
22.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KMO_A_EAAA214_1
(GLUTATHIONE
S-TRANSFERASE P)		 1d5c RAB6 GTPASE
(Plasmodium
falciparum) 		5 / 9 VAL A  90
GLY A 123
GLN A  70
ASN A 124
GLY A  23
 None
None
None
GDP  A 201 (-3.3A)
GDP  A 201 (-3.4A)
 1.33A 3kmoA-1d5cA:
0.0		 3kmoA-1d5cA:
22.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KMO_A_EAAA214_1
(GLUTATHIONE
S-TRANSFERASE P)		 2bov RAS-RELATED PROTEIN
RAL-A
(Homo
sapiens) 		5 / 9 VAL A  92
GLY A 126
GLN A  72
ASN A 127
GLY A  26
 None
None
None
GDP  A1184 (-3.3A)
GDP  A1184 (-3.2A)
 1.38A 3kmoA-2bovA:
undetectable		 3kmoA-2bovA:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_G_TFPG201_1
(PROTEIN S100-A4)		 4jvs PUTATIVE
UNCHARACTERIZED
PROTEIN
RAS-RELATED PROTEIN
RAB-1A
(Homo
sapiens;
Legionella
drancourtii) 		5 / 9 GLY B  69
GLY B  23
ILE B  41
MET A 445
PHE A 448
 AF3  B 401 (-3.7A)
GDP  B 400 (-3.0A)
None
None
None
 1.40A 3ko0F-4jvsB:
undetectable
3ko0G-4jvsB:
undetectable		 3ko0F-4jvsB:
20.99
3ko0G-4jvsB:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_R_TFPR201_1
(PROTEIN S100-A4)		 4jvs PUTATIVE
UNCHARACTERIZED
PROTEIN
RAS-RELATED PROTEIN
RAB-1A
(Homo
sapiens;
Legionella
drancourtii) 		5 / 10 GLY B  23
ILE B  41
MET A 445
PHE A 448
GLY B  69
 GDP  B 400 (-3.0A)
None
None
None
AF3  B 401 (-3.7A)
 1.34A 3ko0R-4jvsB:
undetectable
3ko0T-4jvsB:
undetectable		 3ko0R-4jvsB:
20.99
3ko0T-4jvsB:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3L8L_B_DVAB8_0
(GRAMICIDIN D)		 5igp MACROLIDE
2'-PHOSPHOTRANSFERAS
E
(Escherichia
coli) 		3 / 3 VAL A  92
VAL A  50
TRP A  84
 None
GDP  A 401 (-4.6A)
None
 0.86A 3l8lA-5igpA:
undetectable
3l8lB-5igpA:
undetectable		 3l8lA-5igpA:
5.43
3l8lB-5igpA:
4.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3L8L_D_DVAD8_0
(GRAMICIDIN D)		 5igp MACROLIDE
2'-PHOSPHOTRANSFERAS
E
(Escherichia
coli) 		3 / 3 VAL A  92
VAL A  50
TRP A  84
 None
GDP  A 401 (-4.6A)
None
 0.94A 3l8lC-5igpA:
undetectable
3l8lD-5igpA:
undetectable		 3l8lC-5igpA:
5.43
3l8lD-5igpA:
4.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LBD_A_9CRA424_1
(RETINOIC ACID
RECEPTOR GAMMA)		 2r6r CELL DIVISION
PROTEIN FTSZ
(Aquifex
aeolicus) 		5 / 12 ALA 1 178
ILE 1 165
SER 1 169
GLY 1  18
ILE 1 175
 None
None
None
GDP  1 339 (-3.4A)
None
 1.31A 3lbdA-2r6r1:
undetectable		 3lbdA-2r6r1:
23.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LP9_D_SPMD230_1
(LS-24)		 2nzx ALPHA1,3-FUCOSYLTRAN
SFERASE
(Helicobacter
pylori) 		3 / 3 GLU A  95
GLU A 239
ASN A 240
 None
None
GDP  A3001 (-3.8A)
 0.60A 3lp9B-2nzxA:
undetectable
3lp9D-2nzxA:
undetectable		 3lp9B-2nzxA:
21.14
3lp9D-2nzxA:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LS4_H_TCIH220_1
(HEAVY CHAIN OF
ANTIBODY FAB
FRAGMENT)		 1ofu CELL DIVISION
PROTEIN FTSZ
(Pseudomonas
aeruginosa) 		5 / 10 VAL A  27
LEU A  50
GLY A  24
VAL A  19
GLY A  21
 None
None
None
None
GDP  A1318 (-3.3A)
 1.10A 3ls4H-1ofuA:
undetectable		 3ls4H-1ofuA:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LS4_H_TCIH220_1
(HEAVY CHAIN OF
ANTIBODY FAB
FRAGMENT)		 2r6r CELL DIVISION
PROTEIN FTSZ
(Aquifex
aeolicus) 		5 / 10 VAL 1  23
LEU 1  46
GLY 1  19
VAL 1  15
GLY 1  17
 None
None
None
None
GDP  1 339 (-3.6A)
 1.26A 3ls4H-2r6r1:
undetectable		 3ls4H-2r6r1:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LS4_H_TCIH220_1
(HEAVY CHAIN OF
ANTIBODY FAB
FRAGMENT)		 2vaw CELL DIVISION
PROTEIN FTSZ
(Pseudomonas
aeruginosa) 		5 / 10 VAL A  27
LEU A  50
GLY A  24
VAL A  19
GLY A  21
 None
None
None
None
GDP  A1317 (-3.1A)
 1.14A 3ls4H-2vawA:
undetectable		 3ls4H-2vawA:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MB5_A_SAMA301_1
(SAM-DEPENDENT
METHYLTRANSFERASE)		 1dj3 ADENYLOSUCCINATE
SYNTHETASE
(Triticum
aestivum) 		4 / 4 GLY A  34
GLU A 238
ASP A  30
ASP A  38
 GDP  A 500 (-3.6A)
None
GDP  A 500 (-4.3A)
None
 1.42A 3mb5A-1dj3A:
2.2		 3mb5A-1dj3A:
20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ME6_D_CGED501_1
(CYTOCHROME P450 2B4)		 2dby GTP-BINDING PROTEIN
(Thermus
thermophilus) 		5 / 9 ILE A   6
ALA A  20
THR A  16
VAL A 241
VAL A 106
 None
None
GDP  A 501 (-3.9A)
None
None
 1.17A 3me6D-2dbyA:
undetectable		 3me6D-2dbyA:
20.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N8W_A_FLPA701_1
(PROSTAGLANDIN G/H
SYNTHASE 1)		 1s4o GLYCOLIPID
2-ALPHA-MANNOSYLTRAN
SFERASE
(Saccharomyces
cerevisiae) 		5 / 12 VAL A 172
VAL A 129
LEU A 128
LEU A 137
GLY A 183
 None
GDP  A 800 (-3.8A)
GDP  A 800 (-3.9A)
None
None
 1.04A 3n8wA-1s4oA:
undetectable		 3n8wA-1s4oA:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N8X_A_NIMA701_1
(PROSTAGLANDIN G/H
SYNTHASE 1)		 5foe GDP-FUCOSE PROTEIN
O-FUCOSYLTRANSFERASE
2,THROMBOSPONDIN-1
(Caenorhabditis
elegans;
Homo
sapiens) 		5 / 12 TRP A  85
PHE A 104
ILE A 364
GLY A 360
ALA A 363
 None
None
None
EDO  A1429 ( 3.9A)
GDP  A1428 (-3.8A)
 1.26A 3n8xA-5foeA:
undetectable		 3n8xA-5foeA:
19.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NLY_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 4oro POLYMERASE PB2
(Influenza
B
virus) 		4 / 8 PHE A 365
SER A 407
ARG A 334
TRP A 359
 None
None
GDP  A 501 (-4.1A)
GDP  A 501 (-3.3A)
 1.23A 3nlyA-4oroA:
undetectable
3nlyB-4oroA:
undetectable		 3nlyA-4oroA:
18.21
3nlyB-4oroA:
18.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NRR_A_D16A520_1
(DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 3cx6 GUANINE
NUCLEOTIDE-BINDING
PROTEIN ALPHA-13
SUBUNIT
(Mus
musculus) 		5 / 12 ALA A 349
PHE A 289
LEU A 246
ILE A  51
SER A 242
 GDP  A 775 (-3.2A)
None
None
None
None
 1.13A 3nrrA-3cx6A:
undetectable		 3nrrA-3cx6A:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NRR_B_D16B520_1
(DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 3cx6 GUANINE
NUCLEOTIDE-BINDING
PROTEIN ALPHA-13
SUBUNIT
(Mus
musculus) 		5 / 12 ALA A 349
PHE A 289
LEU A 246
ILE A  51
SER A 242
 GDP  A 775 (-3.2A)
None
None
None
None
 1.09A 3nrrB-3cx6A:
undetectable		 3nrrB-3cx6A:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NY4_A_SMXA309_1
(BETA-LACTAMASE)		 1s4o GLYCOLIPID
2-ALPHA-MANNOSYLTRAN
SFERASE
(Saccharomyces
cerevisiae) 		4 / 5 ILE A 213
ARG A 130
GLU A 247
GLU A 133
 None
GDP  A 800 ( 3.3A)
MN  A 601 ( 3.1A)
GDP  A 800 (-2.9A)
 1.33A 3ny4A-1s4oA:
0.0		 3ny4A-1s4oA:
19.61
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3O0Q_A_ADNA1004_1
(RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE)		 1xje RIBONUCLEOTIDE
REDUCTASE,
B12-DEPENDENT
(Thermotoga
maritima) 		8 / 9 MET A 212
ASN A 242
SER A 244
ASP A 295
GLY A 297
CYH A 322
SER A 596
THR A 626
 None
None
None
None
None
GDP  A1002 (-3.6A)
None
None
 0.54A 3o0qA-1xjeA:
66.1		 3o0qA-1xjeA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3O0Q_A_ADNA1004_1
(RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE)		 1xje RIBONUCLEOTIDE
REDUCTASE,
B12-DEPENDENT
(Thermotoga
maritima) 		8 / 9 MET A 212
ASN A 242
SER A 244
ASP A 295
GLY A 297
CYH A 322
THR A 598
THR A 626
 None
None
None
None
None
GDP  A1002 (-3.6A)
None
None
 0.15A 3o0qA-1xjeA:
66.1		 3o0qA-1xjeA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3O0Q_B_ADNB1004_1
(RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE)		 1xje RIBONUCLEOTIDE
REDUCTASE,
B12-DEPENDENT
(Thermotoga
maritima) 		9 / 9 MET A 212
ASN A 242
SER A 244
ASP A 295
CYH A 322
PRO A 490
SER A 596
THR A 598
THR A 626
 None
None
None
None
GDP  A1002 (-3.6A)
GDP  A1002 (-3.9A)
None
None
None
 0.55A 3o0qB-1xjeA:
63.7		 3o0qB-1xjeA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OGQ_A_AB1A200_1
(FIV PROTEASE)		 5h7k ELONGATION FACTOR 2
(Pyrococcus
horikoshii) 		5 / 10 LEU A  40
ALA A  31
ILE A  33
GLY A 127
ILE A 174
 None
GDP  A 501 ( 4.2A)
None
None
None
 0.95A 3ogqA-5h7kA:
undetectable		 3ogqA-5h7kA:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OHT_B_1N1B1000_2
(P38A)		 1rpn GDP-MANNOSE
4,6-DEHYDRATASE
(Pseudomonas
aeruginosa) 		3 / 3 GLU A 128
LEU A 286
LEU A 305
 GDP  A1601 (-3.7A)
None
None
 0.77A 3ohtB-1rpnA:
undetectable		 3ohtB-1rpnA:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ONN_A_ACTA271_0
(PROTEIN SSM1)		 1ofu CELL DIVISION
PROTEIN FTSZ
(Pseudomonas
aeruginosa) 		4 / 5 GLY A 106
GLU A 139
GLY A 104
PRO A 135
 GDP  A1318 ( 4.3A)
GDP  A1318 (-2.8A)
GDP  A1318 (-3.1A)
GDP  A1318 ( 4.2A)
 1.01A 3onnA-1ofuA:
6.4		 3onnA-1ofuA:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ONN_A_ACTA271_0
(PROTEIN SSM1)		 2r6r CELL DIVISION
PROTEIN FTSZ
(Aquifex
aeolicus) 		4 / 5 GLY 1 102
GLU 1 135
GLY 1 100
PRO 1 131
 GDP  1 339 ( 4.5A)
GDP  1 339 (-2.7A)
GDP  1 339 (-3.3A)
GDP  1 339 ( 4.4A)
 0.99A 3onnA-2r6r1:
6.0		 3onnA-2r6r1:
22.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ONN_A_ACTA271_0
(PROTEIN SSM1)		 2vaw CELL DIVISION
PROTEIN FTSZ
(Pseudomonas
aeruginosa) 		4 / 5 GLY A 106
GLU A 139
GLY A 104
PRO A 135
 GDP  A1317 ( 4.0A)
GDP  A1317 (-2.4A)
GDP  A1317 (-3.1A)
GDP  A1317 ( 4.0A)
 1.06A 3onnA-2vawA:
6.3		 3onnA-2vawA:
19.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ONN_A_ACTA271_0
(PROTEIN SSM1)		 3wgk CELL DIVISION
PROTEIN FTSZ
(Staphylococcus
aureus) 		4 / 5 GLY A 106
GLU A 139
GLY A 104
PRO A 135
 GDP  A 400 ( 4.7A)
GDP  A 400 (-2.6A)
GDP  A 400 ( 3.7A)
GDP  A 400 (-4.3A)
 1.10A 3onnA-3wgkA:
6.5		 3onnA-3wgkA:
19.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ONN_A_ACTA271_0
(PROTEIN SSM1)		 4b46 CELL DIVISION
PROTEIN FTSZ
(Haloferax
volcanii) 		4 / 5 GLY A 108
GLU A 142
GLY A 106
PRO A 138
 GDP  A1368 ( 3.8A)
GDP  A1368 (-2.7A)
GDP  A1368 (-3.6A)
GDP  A1368 (-4.2A)
 0.96A 3onnA-4b46A:
5.1		 3onnA-4b46A:
23.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OWX_B_XRAB233_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 1xje RIBONUCLEOTIDE
REDUCTASE,
B12-DEPENDENT
(Thermotoga
maritima) 		5 / 11 VAL A 136
PHE A 374
GLY A 161
GLY A 160
ASN A  96
 None
None
GDP  A1002 (-4.4A)
GDP  A1002 ( 4.7A)
None
 1.36A 3owxA-1xjeA:
undetectable
3owxB-1xjeA:
undetectable		 3owxA-1xjeA:
16.54
3owxB-1xjeA:
16.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OWX_B_XRAB233_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 1xje RIBONUCLEOTIDE
REDUCTASE,
B12-DEPENDENT
(Thermotoga
maritima) 		5 / 11 VAL A 137
PHE A 374
GLY A 161
GLY A 160
ASN A  96
 None
None
GDP  A1002 (-4.4A)
GDP  A1002 ( 4.7A)
None
 1.38A 3owxA-1xjeA:
undetectable
3owxB-1xjeA:
undetectable		 3owxA-1xjeA:
16.54
3owxB-1xjeA:
16.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P4W_C_DSFC320_1
(GLR4197 PROTEIN)		 3r4v PUTATIVE
UNCHARACTERIZED
PROTEIN
(Pseudomonas
phage
201phi2-1) 		4 / 8 TYR A 161
ILE A 164
VAL A 118
THR A  13
 GDP  A 400 (-3.7A)
GDP  A 400 (-3.7A)
GDP  A 400 (-4.6A)
GDP  A 400 (-3.5A)
 0.82A 3p4wC-3r4vA:
undetectable		 3p4wC-3r4vA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PFG_A_SAMA264_0
(N-METHYLTRANSFERASE)		 3kxi GTP-BINDING PROTEIN
(HFLX)
(Sulfolobus
solfataricus) 		5 / 12 ALA A 335
GLY A 191
LEU A 336
PHE A 196
SER A 198
 GDP  A 500 (-3.8A)
GDP  A 500 (-3.2A)
GDP  A 500 (-3.9A)
None
SCN  A 366 ( 4.0A)
 1.21A 3pfgA-3kxiA:
2.5		 3pfgA-3kxiA:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PFG_A_SAMA264_0
(N-METHYLTRANSFERASE)		 5kut MITOCHONDRIAL RHO
GTPASE 2
(Homo
sapiens) 		5 / 12 GLY A 531
LEU A 528
ASP A 527
PHE A 501
SER A 523
 None
GDP  A 601 (-4.1A)
GDP  A 601 (-3.0A)
None
None
 1.32A 3pfgA-5kutA:
undetectable		 3pfgA-5kutA:
25.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R24_A_SAMA302_0
(2'-O-METHYL
TRANSFERASE)		 3wgk CELL DIVISION
PROTEIN FTSZ
(Staphylococcus
aureus) 		5 / 12 GLY A 104
PRO A 115
GLY A 112
ASP A 187
PHE A 183
 GDP  A 400 ( 3.7A)
None
None
GDP  A 400 (-3.0A)
GDP  A 400 (-3.7A)
 1.49A 3r24A-3wgkA:
4.1		 3r24A-3wgkA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RLB_B_VIBB187_1
(THIT)		 1h65 CHLOROPLAST OUTER
ENVELOPE PROTEIN
OEP34
(Pisum
sativum) 		5 / 12 ILE A 209
GLU A 210
HIS A 163
GLY A  49
VAL A 126
 None
GDP  A 281 (-3.2A)
GDP  A 281 (-3.5A)
GDP  A 281 (-3.5A)
None
 1.31A 3rlbB-1h65A:
0.0		 3rlbB-1h65A:
23.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RQL_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 4oro POLYMERASE PB2
(Influenza
B
virus) 		4 / 8 PHE A 365
SER A 407
ARG A 334
TRP A 359
 None
None
GDP  A 501 (-4.1A)
GDP  A 501 (-3.3A)
 1.15A 3rqlA-4oroA:
undetectable
3rqlB-4oroA:
undetectable		 3rqlA-4oroA:
18.21
3rqlB-4oroA:
18.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RUK_D_AERD601_1
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 3c5c RAS-LIKE PROTEIN 12
(Homo
sapiens) 		5 / 11 ALA A  76
ASN A 134
GLY A  32
THR A  37
VAL A  72
 None
GDP  A 201 (-3.3A)
GDP  A 201 (-3.2A)
None
None
 1.21A 3rukD-3c5cA:
undetectable		 3rukD-3c5cA:
17.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RUN_A_CCSA165_0
(LYSOZYME)		 4xcq TUBZ
(Clostridium
phage
c-st) 		3 / 3 ASN A 139
ALA A  97
LYS A  60
 None
GDP  A 401 (-3.4A)
GDP  A 401 ( 4.5A)
 1.00A 3runA-4xcqA:
undetectable		 3runA-4xcqA:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RXF_A_4APA9_1
(CATIONIC TRYPSIN)		 1zca G ALPHA I/12
(Mus
musculus) 		4 / 6 SER A  66
SER A  69
GLY A 228
GLY A  62
 GDP  A 382 (-2.9A)
MG  A 383 ( 2.1A)
ALF  A 384 (-3.3A)
None
 0.64A 3rxfA-1zcaA:
undetectable		 3rxfA-1zcaA:
18.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RXF_A_4APA9_1
(CATIONIC TRYPSIN)		 2ik8 GUANINE
NUCLEOTIDE-BINDING
PROTEIN G(I),
ALPHA-1 SUBUNIT
(Homo
sapiens) 		4 / 6 SER A  44
SER A  47
GLY A 203
GLY A  40
 GDP  A 401 (-3.6A)
MG  A 356 ( 1.9A)
ALF  A 355 (-3.3A)
None
 0.71A 3rxfA-2ik8A:
undetectable		 3rxfA-2ik8A:
19.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RXF_A_4APA9_1
(CATIONIC TRYPSIN)		 3cx6 GUANINE
NUCLEOTIDE-BINDING
PROTEIN ALPHA-13
SUBUNIT
(Mus
musculus) 		4 / 6 SER A  59
SER A  62
GLY A 225
GLY A  55
 GDP  A 775 (-3.4A)
MG  A 675 ( 2.7A)
None
None
 0.62A 3rxfA-3cx6A:
undetectable		 3rxfA-3cx6A:
20.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RXF_A_4APA9_1
(CATIONIC TRYPSIN)		 3cx6 GUANINE
NUCLEOTIDE-BINDING
PROTEIN ALPHA-13
SUBUNIT
(Mus
musculus) 		5 / 6 SER A 268
SER A 248
VAL A 247
GLY A  57
GLY A  55
 None
None
None
GDP  A 775 ( 4.2A)
None
 1.21A 3rxfA-3cx6A:
undetectable		 3rxfA-3cx6A:
20.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RXF_A_4APA9_1
(CATIONIC TRYPSIN)		 3t34 DYNAMIN-RELATED
PROTEIN 1A, LINKER,
DYNAMIN-RELATED
PROTEIN 1A
(Arabidopsis
thaliana) 		4 / 6 SER A  45
SER A  48
GLY A 145
GLY A  41
 GDP  A1000 (-3.9A)
MG  A1002 ( 2.3A)
ALF  A1001 (-3.5A)
None
 0.73A 3rxfA-3t34A:
undetectable		 3rxfA-3t34A:
21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RXF_A_4APA9_1
(CATIONIC TRYPSIN)		 6au6 GUANINE
NUCLEOTIDE-BINDING
PROTEIN G(S) SUBUNIT
ALPHA ISOFORMS SHORT
(Homo
sapiens) 		4 / 6 SER A  51
SER A  54
GLY A 226
GLY A  47
 GDP  A 401 (-3.4A)
MG  A 402 ( 2.1A)
None
None
 0.61A 3rxfA-6au6A:
undetectable		 3rxfA-6au6A:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S53_A_017A201_2
(PROTEASE)		 3zbq PHIKZ039
(Pseudomonas
virus
phiKZ) 		5 / 11 ALA A  77
ILE A  52
GLY A  13
ILE A  85
ILE A  81
 None
None
GDP  A 999 (-3.6A)
None
None
 1.09A 3s53B-3zbqA:
undetectable		 3s53B-3zbqA:
15.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SFU_A_RBVA601_1
(RNA POLYMERASE)		 2dyk GTP-BINDING PROTEIN
(Thermus
thermophilus) 		5 / 9 ASP A 119
SER A 142
THR A 141
THR A 116
GLY A  89
 GDP  A 501 (-2.8A)
GDP  A 501 (-3.4A)
None
None
None
 1.38A 3sfuA-2dykA:
undetectable		 3sfuA-2dykA:
14.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SGL_A_SAMA692_0
(TRNA
5-METHYLAMINOMETHYL-
2-THIOURIDINE
BIOSYNTHESIS
BIFUNCTIONAL PROTEIN
MNMC)		 4b46 CELL DIVISION
PROTEIN FTSZ
(Haloferax
volcanii) 		5 / 12 GLY A 112
GLY A 106
ASP A  71
VAL A  68
GLY A 115
 GDP  A1368 (-3.5A)
GDP  A1368 (-3.6A)
None
None
None
 1.06A 3sglA-4b46A:
2.4		 3sglA-4b46A:
19.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SI7_B_ACTB4_0
(CYSTIC FIBROSIS
TRANSMEMBRANE
CONDUCTANCE
REGULATOR)		 1ky3 GTP-BINDING PROTEIN
YPT7P
(Saccharomyces
cerevisiae) 		3 / 3 GLY A  18
GLY A  20
THR A  22
 GDP  A 400 (-3.6A)
GDP  A 400 (-3.2A)
MG  A 401 ( 3.1A)
 0.45A 3si7B-1ky3A:
undetectable		 3si7B-1ky3A:
21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SI7_B_ACTB4_0
(CYSTIC FIBROSIS
TRANSMEMBRANE
CONDUCTANCE
REGULATOR)		 1moz ADP-RIBOSYLATION
FACTOR-LIKE PROTEIN
1
(Saccharomyces
cerevisiae) 		3 / 3 GLY A  28
GLY A  30
THR A  32
 GDP  A 184 (-3.7A)
GDP  A 184 (-2.8A)
GDP  A 184 (-3.6A)
 0.41A 3si7B-1mozA:
undetectable		 3si7B-1mozA:
23.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SI7_B_ACTB4_0
(CYSTIC FIBROSIS
TRANSMEMBRANE
CONDUCTANCE
REGULATOR)		 2j1l RHO-RELATED
GTP-BINDING PROTEIN
RHOD
(Homo
sapiens) 		3 / 3 GLY A  27
GLY A  29
THR A  31
 GDP  A1194 (-3.3A)
GDP  A1194 (-3.2A)
MG  A1195 ( 3.4A)
 0.43A 3si7B-2j1lA:
undetectable		 3si7B-2j1lA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SI7_B_ACTB4_0
(CYSTIC FIBROSIS
TRANSMEMBRANE
CONDUCTANCE
REGULATOR)		 2nzj GTP-BINDING PROTEIN
REM 1
(Homo
sapiens) 		3 / 3 GLY A  90
GLY A  92
THR A  94
 GDP  A1001 (-3.7A)
GDP  A1001 (-3.2A)
MG  A 252 ( 3.1A)
 0.46A 3si7B-2nzjA:
undetectable		 3si7B-2nzjA:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SPK_B_TPVB100_1
(HIV-1 PROTEASE)		 2nzj GTP-BINDING PROTEIN
REM 1
(Homo
sapiens) 		5 / 9 LEU A 228
VAL A 232
GLY A 194
ILE A 163
THR A 227
 None
None
None
None
GDP  A1001 (-3.3A)
 1.31A 3spkA-2nzjA:
undetectable		 3spkA-2nzjA:
23.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SXJ_A_SAMA258_0
(PUTATIVE
METHYLTRANSFERASE)		 5c2k TRANSFORMING PROTEIN
RHOA,RAC
GTPASE-ACTIVATING
PROTEIN 1
(Homo
sapiens) 		5 / 12 ARG A 247
GLN A  63
GLY A  12
GLY A  62
ASN A  94
 GDP  A 503 ( 3.5A)
AF3  A 502 (-3.2A)
None
AF3  A 502 (-3.4A)
None
 1.21A 3sxjA-5c2kA:
undetectable		 3sxjA-5c2kA:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SXJ_A_SAMA258_0
(PUTATIVE
METHYLTRANSFERASE)		 5jcp ARF-GAP WITH RHO-GAP
DOMAIN, ANK REPEAT
AND PH
DOMAIN-CONTAINING
PROTEIN
3,LINKER,TRANSFORMIN
G PROTEIN RHOA
(Homo
sapiens;
synthetic
construct) 		5 / 12 ARG B 942
GLN B  63
GLY B  12
GLY B  62
ASN B  94
 GDP  B1201 ( 3.4A)
ALF  B1203 (-3.0A)
None
ALF  B1203 (-3.3A)
None
 1.24A 3sxjA-5jcpB:
undetectable		 3sxjA-5jcpB:
22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SXJ_B_SAMB258_0
(PUTATIVE
METHYLTRANSFERASE)		 5c2k TRANSFORMING PROTEIN
RHOA,RAC
GTPASE-ACTIVATING
PROTEIN 1
(Homo
sapiens) 		5 / 12 ARG A 247
GLN A  63
GLY A  12
GLY A  62
ASN A  94
 GDP  A 503 ( 3.5A)
AF3  A 502 (-3.2A)
None
AF3  A 502 (-3.4A)
None
 1.22A 3sxjB-5c2kA:
undetectable		 3sxjB-5c2kA:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SXJ_B_SAMB258_0
(PUTATIVE
METHYLTRANSFERASE)		 5jcp ARF-GAP WITH RHO-GAP
DOMAIN, ANK REPEAT
AND PH
DOMAIN-CONTAINING
PROTEIN
3,LINKER,TRANSFORMIN
G PROTEIN RHOA
(Homo
sapiens;
synthetic
construct) 		5 / 12 ARG B 942
GLN B  63
GLY B  12
GLY B  62
ASN B  94
 GDP  B1201 ( 3.4A)
ALF  B1203 (-3.0A)
None
ALF  B1203 (-3.3A)
None
 1.25A 3sxjB-5jcpB:
undetectable		 3sxjB-5jcpB:
22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T7S_B_SAMB300_0
(PUTATIVE
METHYLTRANSFERASE)		 5c2k TRANSFORMING PROTEIN
RHOA,RAC
GTPASE-ACTIVATING
PROTEIN 1
(Homo
sapiens) 		5 / 12 ARG A 247
GLN A  63
GLY A  12
GLY A  62
ASN A  94
 GDP  A 503 ( 3.5A)
AF3  A 502 (-3.2A)
None
AF3  A 502 (-3.4A)
None
 1.23A 3t7sB-5c2kA:
undetectable		 3t7sB-5c2kA:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T7S_B_SAMB300_0
(PUTATIVE
METHYLTRANSFERASE)		 5jcp ARF-GAP WITH RHO-GAP
DOMAIN, ANK REPEAT
AND PH
DOMAIN-CONTAINING
PROTEIN
3,LINKER,TRANSFORMIN
G PROTEIN RHOA
(Homo
sapiens;
synthetic
construct) 		5 / 12 ARG B 942
GLN B  63
GLY B  12
GLY B  62
ASN B  94
 GDP  B1201 ( 3.4A)
ALF  B1203 (-3.0A)
None
ALF  B1203 (-3.3A)
None
 1.25A 3t7sB-5jcpB:
undetectable		 3t7sB-5jcpB:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T7S_D_SAMD300_0
(PUTATIVE
METHYLTRANSFERASE)		 5c2k TRANSFORMING PROTEIN
RHOA,RAC
GTPASE-ACTIVATING
PROTEIN 1
(Homo
sapiens) 		5 / 12 ARG A 247
GLN A  63
GLY A  12
GLY A  62
ASN A  94
 GDP  A 503 ( 3.5A)
AF3  A 502 (-3.2A)
None
AF3  A 502 (-3.4A)
None
 1.21A 3t7sD-5c2kA:
undetectable		 3t7sD-5c2kA:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T8N_D_EDTD135_0
(STEROID
DELTA-ISOMERASE)		 3t12 GLIDING PROTEIN MGLA
(Thermus
thermophilus) 		5 / 11 THR A  26
GLY A  24
GLY A  81
PRO A  80
ASP A 104
 MG  A 198 ( 3.1A)
GDP  A 197 (-3.2A)
ALF  A 200 (-3.6A)
ALF  A 200 (-4.9A)
None
 1.30A 3t8nD-3t12A:
undetectable
3t8nF-3t12A:
undetectable		 3t8nD-3t12A:
19.70
3t8nF-3t12A:
19.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TJ7_A_ACTA604_0
(GBAA_1210 PROTEIN)		 2v40 ADENYLOSUCCINATE
SYNTHETASE ISOZYME 2
(Homo
sapiens) 		4 / 6 GLY A  85
VAL A  70
HIS A  68
SER A  84
 None
None
GDP  A1457 (-4.3A)
None
 1.11A 3tj7A-2v40A:
undetectable
3tj7B-2v40A:
undetectable		 3tj7A-2v40A:
17.96
3tj7B-2v40A:
17.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TJ7_C_ACTC606_0
(GBAA_1210 PROTEIN)		 2v40 ADENYLOSUCCINATE
SYNTHETASE ISOZYME 2
(Homo
sapiens) 		4 / 6 GLY A  85
VAL A  70
HIS A  68
SER A  84
 None
None
GDP  A1457 (-4.3A)
None
 1.08A 3tj7C-2v40A:
undetectable
3tj7D-2v40A:
undetectable		 3tj7C-2v40A:
17.96
3tj7D-2v40A:
17.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TJ7_D_ACTD605_0
(GBAA_1210 PROTEIN)		 2v40 ADENYLOSUCCINATE
SYNTHETASE ISOZYME 2
(Homo
sapiens) 		4 / 6 VAL A  70
HIS A  68
SER A  84
GLY A  85
 None
GDP  A1457 (-4.3A)
None
None
 1.11A 3tj7C-2v40A:
undetectable
3tj7D-2v40A:
undetectable		 3tj7C-2v40A:
17.96
3tj7D-2v40A:
17.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TM4_B_SAMB401_0
(TRNA (GUANINE
N2-)-METHYLTRANSFERA
SE TRM14)		 5h7k ELONGATION FACTOR 2
(Pyrococcus
horikoshii) 		5 / 12 ALA A  31
HIS A  32
GLY A 100
ALA A  77
LEU A  95
 GDP  A 501 ( 4.2A)
None
None
None
None
 1.18A 3tm4B-5h7kA:
2.8		 3tm4B-5h7kA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U7S_A_017A202_2
(POL POLYPROTEIN)		 3d45 POLY(A)-SPECIFIC
RIBONUCLEASE PARN
(Mus
musculus) 		5 / 9 ASP A 285
GLY A  29
ASP A 375
ILE A  34
LEU A 283
 None
None
None
GDP  A 652 ( 4.4A)
GDP  A 652 ( 4.2A)
 1.03A 3u7sB-3d45A:
undetectable		 3u7sB-3d45A:
12.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9H_A_NCAA1163_0
(TANKYRASE-2)		 5kx6 GALACTOSIDE
2-ALPHA-L-FUCOSYLTRA
NSFERASE
(Arabidopsis
thaliana) 		4 / 8 GLY A 344
TYR A 349
ALA A 465
GLU A 466
 None
None
None
GDP  A 601 (-3.2A)
 0.86A 3u9hA-5kx6A:
undetectable		 3u9hA-5kx6A:
18.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9H_B_NCAB1164_0
(TANKYRASE-2)		 5kx6 GALACTOSIDE
2-ALPHA-L-FUCOSYLTRA
NSFERASE
(Arabidopsis
thaliana) 		4 / 8 GLY A 344
TYR A 349
ALA A 465
GLU A 466
 None
None
None
GDP  A 601 (-3.2A)
 0.80A 3u9hB-5kx6A:
undetectable		 3u9hB-5kx6A:
18.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UCB_A_017A201_1
(PROTEASE)		 5hci GPN-LOOP GTPASE 1
(Saccharomyces
cerevisiae) 		6 / 12 ASP A  40
GLY A 109
GLY A  15
PRO A  47
VAL A  46
VAL A  43
 None
GDP  A 301 ( 4.4A)
GDP  A 301 (-3.0A)
None
None
None
 1.40A 3ucbA-5hciA:
undetectable		 3ucbA-5hciA:
17.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UCB_A_017A201_2
(PROTEASE)		 5hci GPN-LOOP GTPASE 1
(Saccharomyces
cerevisiae) 		6 / 12 ASP A  40
GLY A 109
GLY A  15
PRO A  47
VAL A  46
VAL A  43
 None
GDP  A 301 ( 4.4A)
GDP  A 301 (-3.0A)
None
None
None
 1.32A 3ucbB-5hciA:
undetectable		 3ucbB-5hciA:
17.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UJ6_A_SAMA300_1
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE)		 5c2k TRANSFORMING PROTEIN
RHOA,RAC
GTPASE-ACTIVATING
PROTEIN 1
(Homo
sapiens) 		4 / 4 SER A  85
ASP A 249
ASP A  65
ALA A  15
 None
None
None
GDP  A 503 ( 4.2A)
 1.48A 3uj6A-5c2kA:
undetectable		 3uj6A-5c2kA:
19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UR0_B_SVRB516_1
(RNA-DEPENDENT RNA
POLYMERASE)		 2www METHYLMALONIC
ACIDURIA TYPE A
PROTEIN,
MITOCHONDRIAL
(Homo
sapiens) 		4 / 7 PRO A 151
GLY A 153
ALA A 154
ALA A 267
 None
GDP  A 600 (-3.5A)
GDP  A 600 (-4.2A)
None
 0.77A 3ur0B-2wwwA:
undetectable		 3ur0B-2wwwA:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V8V_A_SAMA801_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE L)		 2h18 ADP-RIBOSYLATION
FACTOR-LIKE PROTEIN
8A
(Homo
sapiens) 		5 / 12 ILE A 144
GLY A 129
SER A  31
ASP A  97
VAL A  26
 None
None
GDP  A 201 (-3.4A)
None
None
 1.15A 3v8vA-2h18A:
undetectable		 3v8vA-2h18A:
13.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VQR_A_ACTA1002_0
(PUTATIVE
OXIDOREDUCTASE)		 1z0a RAS-RELATED PROTEIN
RAB-2A
(Homo
sapiens) 		4 / 6 ASP A  14
GLY A  16
VAL A  17
ASP A  87
 None
GDP  A1200 (-3.3A)
GDP  A1200 (-4.1A)
None
 1.15A 3vqrA-1z0aA:
undetectable		 3vqrA-1z0aA:
17.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VQR_B_ACTB1002_0
(PUTATIVE
OXIDOREDUCTASE)		 1z0a RAS-RELATED PROTEIN
RAB-2A
(Homo
sapiens) 		4 / 5 ASP A  14
GLY A  16
VAL A  17
ASP A  87
 None
GDP  A1200 (-3.3A)
GDP  A1200 (-4.1A)
None
 1.16A 3vqrB-1z0aA:
2.3		 3vqrB-1z0aA:
17.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VW1_D_CVID301_0
(PUTATIVE REGULATORY
PROTEIN)		 4n9w GDP-MANNOSE-DEPENDEN
T
ALPHA-(1-2)-PHOSPHAT
IDYLINOSITOL
MANNOSYLTRANSFERASE
(Mycolicibacteriu
m
smegmatis) 		5 / 12 LEU A 194
ILE A 278
ALA A 263
VAL A 344
PHE A 175
 GDP  A 401 (-4.8A)
GDP  A 401 (-4.9A)
None
None
None
 1.14A 3vw1D-4n9wA:
undetectable		 3vw1D-4n9wA:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VYW_A_SAMA501_1
(MNMC2)		 1dj3 ADENYLOSUCCINATE
SYNTHETASE
(Triticum
aestivum) 		4 / 6 HIS A  79
GLU A 238
ASP A  30
ASP A  38
 None
None
GDP  A 500 (-4.3A)
None
 1.31A 3vywA-1dj3A:
undetectable		 3vywA-1dj3A:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W1W_A_CHDA1507_0
(FERROCHELATASE,
MITOCHONDRIAL)		 1z0a RAS-RELATED PROTEIN
RAB-2A
(Homo
sapiens) 		3 / 3 ARG A 126
LYS A 120
ARG A  90
 None
GDP  A1200 (-3.4A)
None
 1.44A 3w1wA-1z0aA:
0.4
3w1wB-1z0aA:
0.5		 3w1wA-1z0aA:
19.47
3w1wB-1z0aA:
19.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W1W_B_CHDB506_0
(FERROCHELATASE,
MITOCHONDRIAL)		 1z0a RAS-RELATED PROTEIN
RAB-2A
(Homo
sapiens) 		3 / 3 ARG A  90
ARG A 126
LYS A 120
 None
None
GDP  A1200 (-3.4A)
 1.38A 3w1wA-1z0aA:
0.4
3w1wB-1z0aA:
0.5		 3w1wA-1z0aA:
19.47
3w1wB-1z0aA:
19.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W67_D_VIVD301_0
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)		 3zbq PHIKZ039
(Pseudomonas
virus
phiKZ) 		5 / 12 ILE A 132
ILE A 182
VAL A 185
LEU A 186
ILE A   9
 GDP  A 999 (-4.1A)
None
None
None
None
 1.30A 3w67D-3zbqA:
undetectable		 3w67D-3zbqA:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W68_B_VIVB301_0
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)		 1xje RIBONUCLEOTIDE
REDUCTASE,
B12-DEPENDENT
(Thermotoga
maritima) 		5 / 12 VAL A  52
PHE A  87
ILE A 494
LEU A  94
VAL A  48
 None
None
GDP  A1002 (-3.9A)
None
None
 1.02A 3w68B-1xjeA:
1.2		 3w68B-1xjeA:
18.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A3U_A_ACTA1358_0
(NADH:FLAVIN
OXIDOREDUCTASE/NADH
OXIDASE)		 4m8n PLEXINC1
INTRACELLULAR REGION
RAS-RELATED PROTEIN
RAP-1B
(Danio
rerio;
Homo
sapiens) 		5 / 9 PRO E  34
GLN E  63
ARG A 711
GLY E  12
VAL E  14
 AF3  E 202 ( 4.3A)
AF3  E 202 (-3.5A)
GDP  E 201 ( 2.9A)
AF3  E 202 (-3.5A)
GDP  E 201 (-4.3A)
 1.47A 4a3uA-4m8nE:
undetectable		 4a3uA-4m8nE:
18.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A3U_B_ACTB1358_0
(NADH:FLAVIN
OXIDOREDUCTASE/NADH
OXIDASE)		 4m8n PLEXINC1
INTRACELLULAR REGION
RAS-RELATED PROTEIN
RAP-1B
(Danio
rerio;
Homo
sapiens) 		5 / 7 PRO E  34
GLN E  63
ARG A 711
GLY E  12
VAL E  14
 AF3  E 202 ( 4.3A)
AF3  E 202 (-3.5A)
GDP  E 201 ( 2.9A)
AF3  E 202 (-3.5A)
GDP  E 201 (-4.3A)
 1.48A 4a3uB-4m8nE:
undetectable		 4a3uB-4m8nE:
18.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A3U_B_ACTB1358_0
(NADH:FLAVIN
OXIDOREDUCTASE/NADH
OXIDASE)		 5c2k TRANSFORMING PROTEIN
RHOA,RAC
GTPASE-ACTIVATING
PROTEIN 1
(Homo
sapiens) 		4 / 7 PRO A  36
GLN A  63
ARG A 247
GLY A  14
 AF3  A 502 (-4.5A)
AF3  A 502 (-3.2A)
GDP  A 503 ( 3.5A)
AF3  A 502 (-3.3A)
 0.90A 4a3uB-5c2kA:
undetectable		 4a3uB-5c2kA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_A_ZPCA1318_2
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 1wkk NUCLEOSIDE
DIPHOSPHATE KINASE
(Thermus
thermophilus) 		4 / 7 ARG A 102
ILE A 114
ASN A 112
GLU A  51
 GDP  A1001 ( 4.7A)
None
GDP  A1001 (-3.9A)
None
 0.99A 4a97E-1wkkA:
undetectable		 4a97E-1wkkA:
18.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_B_ZPCB1318_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 1wkk NUCLEOSIDE
DIPHOSPHATE KINASE
(Thermus
thermophilus) 		5 / 12 ARG A 102
ILE A 114
ASN A 112
GLU A  51
VAL A   6
 GDP  A1001 ( 4.7A)
None
GDP  A1001 (-3.9A)
None
None
 1.39A 4a97A-1wkkA:
1.0
4a97B-1wkkA:
0.9		 4a97A-1wkkA:
18.63
4a97B-1wkkA:
18.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AC9_C_DXCC1478_0
(MJ0495-LIKE PROTEIN)		 3tr5 PEPTIDE CHAIN
RELEASE FACTOR 3
(Coxiella
burnetii) 		4 / 7 ASP A 142
GLY A 171
SER A 254
PHE A 259
 GDP  A 527 (-2.7A)
None
GDP  A 527 (-3.0A)
None
 0.86A 4ac9C-3tr5A:
15.6		 4ac9C-3tr5A:
22.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4APJ_A_ACTA1635_0
(ANGIOTENSIN-CONVERTI
NG ENZYME
BRADYKININ-POTENTIAT
ING PEPTIDE B)		 3gp9 NUCLEOSIDE
DIPHOSPHATE KINASE
(Acanthamoeba
polyphaga
mimivirus) 		4 / 6 HIS A 112
GLU A 123
ASP A 115
SER A 119
 GDP  A 138 ( 3.5A)
None
None
None
 1.28A 4apjA-3gp9A:
undetectable
4apjP-3gp9A:
undetectable		 4apjA-3gp9A:
11.19
4apjP-3gp9A:
7.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AX8_A_SAMA1474_0
(WBDD)		 1z6x ADP-RIBOSYLATION
FACTOR 4
(Homo
sapiens) 		5 / 12 GLY A  29
ALA A  27
ILE A  33
VAL A  91
ILE A  89
 GDP  A 201 (-3.0A)
GDP  A 201 (-4.1A)
None
None
None
 0.87A 4ax8A-1z6xA:
2.5		 4ax8A-1z6xA:
14.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AX8_A_SAMA1474_0
(WBDD)		 3aq4 ADP-RIBOSYLATION
FACTOR 1
(Arabidopsis
thaliana) 		5 / 12 GLY A  29
ALA A  27
ILE A  33
VAL A  91
ILE A  89
 GDP  A 183 (-3.3A)
GDP  A 183 (-4.3A)
None
None
None
 0.87A 4ax8A-3aq4A:
undetectable		 4ax8A-3aq4A:
15.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AX8_A_SAMA1474_0
(WBDD)		 3lrp ADP-RIBOSYLATION
FACTOR 1
(Plasmodium
falciparum) 		5 / 12 GLY A  29
ALA A  27
ILE A  33
VAL A  91
ILE A  89
 GDP  A 182 (-3.1A)
GDP  A 182 (-4.3A)
None
None
None
 0.92A 4ax8A-3lrpA:
3.3		 4ax8A-3lrpA:
14.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AX8_A_SAMA1474_0
(WBDD)		 3lvr ARF-GAP WITH SH3
DOMAIN, ANK REPEAT
AND PH
DOMAIN-CONTAINING
PROTEIN 3,
ADP-RIBOSYLATION
FACTOR 6
(Homo
sapiens;
synthetic
construct) 		5 / 12 GLY E  25
ALA E  23
ILE E  29
VAL E  87
ILE E  85
 GDP  E 737 (-3.2A)
GDP  E 737 ( 4.4A)
None
None
None
 0.86A 4ax8A-3lvrE:
3.0		 4ax8A-3lvrE:
23.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AX8_A_SAMA1474_0
(WBDD)		 3o47 ADP-RIBOSYLATION
FACTOR
GTPASE-ACTIVATING
PROTEIN 1,
ADP-RIBOSYLATION
FACTOR 1
(Homo
sapiens) 		5 / 12 GLY A 159
ALA A 157
ILE A 163
VAL A 221
ILE A 219
 GDP  A 502 (-3.2A)
GDP  A 502 (-4.4A)
None
None
None
 0.84A 4ax8A-3o47A:
undetectable		 4ax8A-3o47A:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AX8_A_SAMA1474_0
(WBDD)		 4ylg ADP-RIBOSYLATION
FACTOR
(Entamoeba
histolytica) 		5 / 12 GLY A  25
ALA A  23
ILE A  29
VAL A  87
ILE A  85
 GDP  A 201 (-3.3A)
GDP  A 201 (-4.2A)
None
None
None
 0.86A 4ax8A-4ylgA:
undetectable		 4ax8A-4ylgA:
15.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AX8_A_SAMA1474_0
(WBDD)		 5uf8 POTENTIAL
ADP-RIBOSYLATION
FACTOR
(Candida
albicans) 		5 / 12 GLY A  29
ALA A  27
ILE A  33
VAL A  91
ILE A  89
 GDP  A 500 (-3.2A)
GDP  A 500 (-4.2A)
None
None
None
 0.83A 4ax8A-5uf8A:
undetectable		 4ax8A-5uf8A:
15.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AZT_A_SAMA1472_0
(METHYLTRANSFERASE
WBDD)		 1z6x ADP-RIBOSYLATION
FACTOR 4
(Homo
sapiens) 		5 / 12 GLY A  29
ALA A  27
ILE A  33
VAL A  91
ILE A  89
 GDP  A 201 (-3.0A)
GDP  A 201 (-4.1A)
None
None
None
 0.89A 4aztA-1z6xA:
undetectable		 4aztA-1z6xA:
14.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AZT_A_SAMA1472_0
(METHYLTRANSFERASE
WBDD)		 3aq4 ADP-RIBOSYLATION
FACTOR 1
(Arabidopsis
thaliana) 		5 / 12 GLY A  29
ALA A  27
ILE A  33
VAL A  91
ILE A  89
 GDP  A 183 (-3.3A)
GDP  A 183 (-4.3A)
None
None
None
 0.89A 4aztA-3aq4A:
undetectable		 4aztA-3aq4A:
15.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AZT_A_SAMA1472_0
(METHYLTRANSFERASE
WBDD)		 3lrp ADP-RIBOSYLATION
FACTOR 1
(Plasmodium
falciparum) 		5 / 12 GLY A  29
ALA A  27
ILE A  33
VAL A  91
ILE A  89
 GDP  A 182 (-3.1A)
GDP  A 182 (-4.3A)
None
None
None
 0.94A 4aztA-3lrpA:
2.4		 4aztA-3lrpA:
14.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AZT_A_SAMA1472_0
(METHYLTRANSFERASE
WBDD)		 3lvr ARF-GAP WITH SH3
DOMAIN, ANK REPEAT
AND PH
DOMAIN-CONTAINING
PROTEIN 3,
ADP-RIBOSYLATION
FACTOR 6
(Homo
sapiens;
synthetic
construct) 		5 / 12 GLY E  25
ALA E  23
ILE E  29
VAL E  87
ILE E  85
 GDP  E 737 (-3.2A)
GDP  E 737 ( 4.4A)
None
None
None
 0.86A 4aztA-3lvrE:
2.5		 4aztA-3lvrE:
23.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AZT_A_SAMA1472_0
(METHYLTRANSFERASE
WBDD)		 3o47 ADP-RIBOSYLATION
FACTOR
GTPASE-ACTIVATING
PROTEIN 1,
ADP-RIBOSYLATION
FACTOR 1
(Homo
sapiens) 		5 / 12 GLY A 159
ALA A 157
ILE A 163
VAL A 221
ILE A 219
 GDP  A 502 (-3.2A)
GDP  A 502 (-4.4A)
None
None
None
 0.85A 4aztA-3o47A:
undetectable		 4aztA-3o47A:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AZT_A_SAMA1472_0
(METHYLTRANSFERASE
WBDD)		 4ylg ADP-RIBOSYLATION
FACTOR
(Entamoeba
histolytica) 		5 / 12 GLY A  25
ALA A  23
ILE A  29
VAL A  87
ILE A  85
 GDP  A 201 (-3.3A)
GDP  A 201 (-4.2A)
None
None
None
 0.88A 4aztA-4ylgA:
undetectable		 4aztA-4ylgA:
15.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AZT_A_SAMA1472_0
(METHYLTRANSFERASE
WBDD)		 5uf8 POTENTIAL
ADP-RIBOSYLATION
FACTOR
(Candida
albicans) 		5 / 12 GLY A  29
ALA A  27
ILE A  33
VAL A  91
ILE A  89
 GDP  A 500 (-3.2A)
GDP  A 500 (-4.2A)
None
None
None
 0.85A 4aztA-5uf8A:
undetectable		 4aztA-5uf8A:
15.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AZV_A_SAMA1474_0
(WBDD)		 1z6x ADP-RIBOSYLATION
FACTOR 4
(Homo
sapiens) 		5 / 12 GLY A  29
ALA A  27
ILE A  33
VAL A  91
ILE A  89
 GDP  A 201 (-3.0A)
GDP  A 201 (-4.1A)
None
None
None
 0.87A 4azvA-1z6xA:
undetectable		 4azvA-1z6xA:
14.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AZV_A_SAMA1474_0
(WBDD)		 3aq4 ADP-RIBOSYLATION
FACTOR 1
(Arabidopsis
thaliana) 		5 / 12 GLY A  29
ALA A  27
ILE A  33
VAL A  91
ILE A  89
 GDP  A 183 (-3.3A)
GDP  A 183 (-4.3A)
None
None
None
 0.87A 4azvA-3aq4A:
2.0		 4azvA-3aq4A:
15.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AZV_A_SAMA1474_0
(WBDD)		 3lrp ADP-RIBOSYLATION
FACTOR 1
(Plasmodium
falciparum) 		5 / 12 GLY A  29
ALA A  27
ILE A  33
VAL A  91
ILE A  89
 GDP  A 182 (-3.1A)
GDP  A 182 (-4.3A)
None
None
None
 0.91A 4azvA-3lrpA:
2.1		 4azvA-3lrpA:
14.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AZV_A_SAMA1474_0
(WBDD)		 3lvr ARF-GAP WITH SH3
DOMAIN, ANK REPEAT
AND PH
DOMAIN-CONTAINING
PROTEIN 3,
ADP-RIBOSYLATION
FACTOR 6
(Homo
sapiens;
synthetic
construct) 		5 / 12 GLY E  25
ALA E  23
ILE E  29
VAL E  87
ILE E  85
 GDP  E 737 (-3.2A)
GDP  E 737 ( 4.4A)
None
None
None
 0.84A 4azvA-3lvrE:
3.3		 4azvA-3lvrE:
23.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AZV_A_SAMA1474_0
(WBDD)		 3o47 ADP-RIBOSYLATION
FACTOR
GTPASE-ACTIVATING
PROTEIN 1,
ADP-RIBOSYLATION
FACTOR 1
(Homo
sapiens) 		5 / 12 GLY A 159
ALA A 157
ILE A 163
VAL A 221
ILE A 219
 GDP  A 502 (-3.2A)
GDP  A 502 (-4.4A)
None
None
None
 0.83A 4azvA-3o47A:
undetectable		 4azvA-3o47A:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AZV_A_SAMA1474_0
(WBDD)		 4ylg ADP-RIBOSYLATION
FACTOR
(Entamoeba
histolytica) 		5 / 12 GLY A  25
ALA A  23
ILE A  29
VAL A  87
ILE A  85
 GDP  A 201 (-3.3A)
GDP  A 201 (-4.2A)
None
None
None
 0.85A 4azvA-4ylgA:
undetectable		 4azvA-4ylgA:
15.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AZV_A_SAMA1474_1
(WBDD)		 5mjs TUBULIN BETA CHAIN
(Schizosaccharomy
ces
pombe) 		4 / 6 GLN A   8
ASP A  67
GLN A  11
GLU A 108
 None
None
GDP  A 500 (-3.1A)
None
 1.35A 4azvA-5mjsA:
undetectable		 4azvA-5mjsA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4B17_A_SAMA1358_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE M)		 4n9w GDP-MANNOSE-DEPENDEN
T
ALPHA-(1-2)-PHOSPHAT
IDYLINOSITOL
MANNOSYLTRANSFERASE
(Mycolicibacteriu
m
smegmatis) 		5 / 12 SER A  19
GLY A  15
GLY A  16
ASP A 198
VAL A 226
 GDP  A 401 ( 4.0A)
GDP  A 401 (-3.6A)
GDP  A 401 (-3.7A)
None
GDP  A 401 (-4.9A)
 1.12A 4b17A-4n9wA:
3.6		 4b17A-4n9wA:
22.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BJC_A_RPBA2162_1
(TANKYRASE-2)		 5kx6 GALACTOSIDE
2-ALPHA-L-FUCOSYLTRA
NSFERASE
(Arabidopsis
thaliana) 		4 / 8 GLY A 344
TYR A 349
ALA A 465
GLU A 466
 None
None
None
GDP  A 601 (-3.2A)
 0.84A 4bjcA-5kx6A:
undetectable		 4bjcA-5kx6A:
18.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BUP_A_SAMA500_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SUV420H1)		 3cph RAS-RELATED PROTEIN
SEC4
(Saccharomyces
cerevisiae) 		5 / 12 GLU A  80
GLY A  78
ALA A  77
HIS A 121
TYR A  90
 GDP  A 302 ( 4.7A)
None
None
None
None
 1.42A 4bupA-3cphA:
undetectable		 4bupA-3cphA:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BWL_C_MN9C1297_0
(N-ACETYLNEURAMINATE
LYASE)		 3zbq PHIKZ039
(Pseudomonas
virus
phiKZ) 		5 / 10 ILE A  81
LEU A  80
THR A 111
GLY A 109
GLY A  13
 None
None
None
GDP  A 999 (-3.5A)
GDP  A 999 (-3.6A)
 1.27A 4bwlC-3zbqA:
undetectable		 4bwlC-3zbqA:
19.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CAP_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 4oro POLYMERASE PB2
(Influenza
B
virus) 		4 / 8 PHE A 365
SER A 407
ARG A 334
TRP A 359
 None
None
GDP  A 501 (-4.1A)
GDP  A 501 (-3.3A)
 1.19A 4capA-4oroA:
undetectable
4capB-4oroA:
undetectable		 4capA-4oroA:
18.21
4capB-4oroA:
18.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CX7_A_H4BA600_1
(NITRIC OXIDE
SYNTHASE, INDUCIBLE)		 4oro POLYMERASE PB2
(Influenza
B
virus) 		4 / 8 SER A 407
ARG A 334
TRP A 359
PHE A 365
 None
GDP  A 501 (-4.1A)
GDP  A 501 (-3.3A)
None
 1.10A 4cx7A-4oroA:
undetectable
4cx7B-4oroA:
undetectable		 4cx7A-4oroA:
17.79
4cx7B-4oroA:
17.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D32_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 4oro POLYMERASE PB2
(Influenza
B
virus) 		4 / 8 PHE A 365
SER A 407
ARG A 334
TRP A 359
 None
None
GDP  A 501 (-4.1A)
GDP  A 501 (-3.3A)
 1.18A 4d32A-4oroA:
undetectable
4d32B-4oroA:
undetectable		 4d32A-4oroA:
18.21
4d32B-4oroA:
18.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DCM_A_SAMA401_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE G)		 2o52 RAS-RELATED PROTEIN
RAB-4B
(Homo
sapiens) 		5 / 11 ALA A 152
GLY A  18
GLU A  94
ASN A  97
ASN A 121
 GDP  A 601 (-3.6A)
GDP  A 601 (-3.5A)
None
None
GDP  A 601 (-3.3A)
 1.09A 4dcmA-2o52A:
3.6		 4dcmA-2o52A:
22.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DT8_A_ADNA401_1
(APH(2'')-ID)		 3tdw GENTAMICIN
RESISTANCE PROTEIN
(Enterococcus
gallinarum) 		6 / 11 GLY A  28
ALA A  35
PRO A  75
HIS A 201
LEU A 203
ILE A 217
 GDP  A 500 (-3.4A)
GDP  A 500 (-3.6A)
None
MG  A 501 ( 3.4A)
None
GDP  A 500 ( 4.1A)
 0.52A 4dt8A-3tdwA:
29.6		 4dt8A-3tdwA:
29.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DT8_B_ADNB401_1
(APH(2'')-ID)		 3tdw GENTAMICIN
RESISTANCE PROTEIN
(Enterococcus
gallinarum) 		5 / 10 GLY A  28
ALA A  35
PRO A  75
LEU A 203
ILE A 217
 GDP  A 500 (-3.4A)
GDP  A 500 (-3.6A)
None
None
GDP  A 500 ( 4.1A)
 0.37A 4dt8B-3tdwA:
29.9		 4dt8B-3tdwA:
29.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DTA_A_ADNA401_1
(APH(2'')-ID)		 3tdw GENTAMICIN
RESISTANCE PROTEIN
(Enterococcus
gallinarum) 		6 / 10 ALA A  35
PRO A  75
LYS A  94
HIS A 201
LEU A 203
ILE A 217
 GDP  A 500 (-3.6A)
None
GDP  A 500 (-4.3A)
MG  A 501 ( 3.4A)
None
GDP  A 500 ( 4.1A)
 0.65A 4dtaA-3tdwA:
29.7		 4dtaA-3tdwA:
29.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DTA_B_ADNB401_1
(APH(2'')-ID)		 3tdw GENTAMICIN
RESISTANCE PROTEIN
(Enterococcus
gallinarum) 		4 / 8 PRO A  75
LYS A  94
LEU A 203
ILE A 217
 None
GDP  A 500 (-4.3A)
None
GDP  A 500 ( 4.1A)
 0.63A 4dtaB-3tdwA:
30.0		 4dtaB-3tdwA:
29.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EAT_A_BEZA1000_0
(BENZOATE-COENZYME A
LIGASE)		 5hci GPN-LOOP GTPASE 1
(Saccharomyces
cerevisiae) 		4 / 7 GLY A 109
ILE A 111
GLY A  10
ILE A   9
 GDP  A 301 ( 4.4A)
None
None
None
 0.67A 4eatA-5hciA:
undetectable		 4eatA-5hciA:
18.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EY7_A_E20A604_1
(ACETYLCHOLINESTERASE)		 3zid TUBULIN/FTSZ, GTPASE
(Methanothrix
thermoacetophila) 		5 / 11 GLY A 114
TYR A 152
SER A 118
TYR A 190
GLY A  10
 GDP  A 999 (-3.3A)
GDP  A 999 ( 4.4A)
None
GDP  A 999 (-3.4A)
GDP  A 999 (-3.5A)
 1.48A 4ey7A-3zidA:
3.1		 4ey7A-3zidA:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EY7_B_E20B605_1
(ACETYLCHOLINESTERASE)		 3zid TUBULIN/FTSZ, GTPASE
(Methanothrix
thermoacetophila) 		5 / 11 GLY A 114
TYR A 152
SER A 118
TYR A 190
GLY A  10
 GDP  A 999 (-3.3A)
GDP  A 999 ( 4.4A)
None
GDP  A 999 (-3.4A)
GDP  A 999 (-3.5A)
 1.48A 4ey7B-3zidA:
3.7		 4ey7B-3zidA:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EYR_B_RITB301_2
(HIV-1 PROTEASE)		 1ofu CELL DIVISION
PROTEIN FTSZ
(Pseudomonas
aeruginosa) 		4 / 8 GLY A 192
ALA A 193
PRO A 165
THR A 133
 None
None
None
GDP  A1318 ( 4.9A)
 0.73A 4eyrB-1ofuA:
undetectable		 4eyrB-1ofuA:
15.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F3T_A_IPHA902_0
(PROTEIN ARGONAUTE-2)		 1p9b ADENYLOSUCCINATE
SYNTHETASE
(Plasmodium
falciparum) 		4 / 6 LEU A 343
LYS A 339
LEU A 298
GLU A 304
 None
GDP  A1603 (-2.9A)
None
None
 1.14A 4f3tA-1p9bA:
undetectable		 4f3tA-1p9bA:
18.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F4D_A_CHDA505_0
(FERROCHELATASE,
MITOCHONDRIAL)		 1wkk NUCLEOSIDE
DIPHOSPHATE KINASE
(Thermus
thermophilus) 		4 / 7 MET A  73
ILE A 114
ARG A 102
VAL A  80
 None
None
GDP  A1001 ( 4.7A)
None
 1.36A 4f4dA-1wkkA:
undetectable		 4f4dA-1wkkA:
17.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F84_A_SAMA501_0
(GERANYL DIPHOSPHATE
2-C-METHYLTRANSFERAS
E)		 3wgk CELL DIVISION
PROTEIN FTSZ
(Staphylococcus
aureus) 		5 / 12 GLY A 110
GLY A 106
THR A 111
SER A 103
VAL A 101
 GDP  A 400 (-3.4A)
GDP  A 400 ( 4.7A)
None
None
None
 1.09A 4f84A-3wgkA:
3.5		 4f84A-3wgkA:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FAK_A_SAMA201_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE H)		 1dj3 ADENYLOSUCCINATE
SYNTHETASE
(Triticum
aestivum) 		5 / 10 LEU A 349
ILE A 430
GLY A 431
GLY A 433
SER A 397
 None
None
GDP  A 500 (-3.2A)
GDP  A 500 (-3.2A)
None
 0.98A 4fakA-1dj3A:
undetectable		 4fakA-1dj3A:
15.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGL_C_CLQC303_0
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 3zf8 MANNAN POLYMERASE
COMPLEXES SUBUNIT
MNN9
(Saccharomyces
cerevisiae) 		4 / 5 GLY A 337
GLY A 338
ASN A 236
GLU A 366
 None
None
GDP  A1395 (-3.5A)
None
 1.23A 4fglC-3zf8A:
undetectable		 4fglC-3zf8A:
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FO4_A_MOAA502_1
(INOSINE
5'-MONOPHOSPHATE
DEHYDROGENASE)		 4v0k ARF-LIKE SMALL
GTPASE
(Chlamydomonas
reinhardtii) 		4 / 8 ASP A  95
SER A  28
ASN A  27
GLY A 162
 None
GDP  A 700 (-3.1A)
GDP  A 700 (-4.2A)
GDP  A 700 (-3.7A)
 0.96A 4fo4A-4v0kA:
undetectable		 4fo4A-4v0kA:
18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FWD_A_BO2A801_1
(TTC1975 PEPTIDASE)		 4c7o SIGNAL RECOGNITION
PARTICLE PROTEIN
(Escherichia
coli) 		5 / 9 VAL A 246
VAL A 245
VAL A 103
GLY A 107
ALA A 111
 None
None
None
None
GDP  A1003 (-4.1A)
 0.98A 4fwdA-4c7oA:
1.9		 4fwdA-4c7oA:
18.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HVR_A_SALA203_1
(3-HYDROXYANTHRANILAT
E 3,4-DIOXYGENASE)		 5igp MACROLIDE
2'-PHOSPHOTRANSFERAS
E
(Escherichia
coli) 		4 / 7 ASP A 219
HIS A 198
VAL A  69
GLU A  66
 GDP  A 401 (-2.6A)
None
None
None
 1.12A 4hvrA-5igpA:
undetectable		 4hvrA-5igpA:
19.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HYT_A_OBNA1104_1
(SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1)		 2r6r CELL DIVISION
PROTEIN FTSZ
(Aquifex
aeolicus) 		5 / 12 GLY 1 106
ALA 1 109
LEU 1  46
THR 1  41
ILE 1  57
 GDP  1 339 (-3.5A)
None
None
None
None
 1.18A 4hytA-2r6r1:
5.9		 4hytA-2r6r1:
17.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HYT_C_OBNC2004_1
(SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1)		 2r6r CELL DIVISION
PROTEIN FTSZ
(Aquifex
aeolicus) 		5 / 12 GLY 1 106
ALA 1 109
LEU 1  46
THR 1  41
ILE 1  57
 GDP  1 339 (-3.5A)
None
None
None
None
 1.15A 4hytC-2r6r1:
2.0		 4hytC-2r6r1:
17.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4I13_A_FOLA201_1
(DIHYDROFOLATE
REDUCTASE)		 1zca G ALPHA I/12
(Mus
musculus) 		3 / 3 ASP A 297
ARG A 168
THR A 350
 GDP  A 382 (-3.1A)
None
GDP  A 382 (-3.7A)
 0.89A 4i13A-1zcaA:
undetectable		 4i13A-1zcaA:
18.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IB4_A_ERMA2001_1
(CHIMERA PROTEIN OF
HUMAN
5-HYDROXYTRYPTAMINE
RECEPTOR 2B AND E.
COLI SOLUBLE
CYTOCHROME B562)		 2x77 ADP-RIBOSYLATION
FACTOR
(Leishmania
major) 		5 / 12 LEU A  37
SER A 163
MET A 173
PHE A 127
VAL A  94
 None
GDP  A 188 (-4.2A)
None
None
None
 1.21A 4ib4A-2x77A:
undetectable		 4ib4A-2x77A:
18.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IFX_A_ACTA404_0
(THIAMINE
BIOSYNTHESIS
LIPOPROTEIN APBE)		 1p9b ADENYLOSUCCINATE
SYNTHETASE
(Plasmodium
falciparum) 		4 / 5 SER A 276
LYS A 275
LEU A 340
ASP A 341
 None
None
None
GDP  A1603 (-2.8A)
 1.15A 4ifxA-1p9bA:
0.0		 4ifxA-1p9bA:
19.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IG1_A_ACTA504_0
(FAD:PROTEIN FMN
TRANSFERASE)		 1p9b ADENYLOSUCCINATE
SYNTHETASE
(Plasmodium
falciparum) 		4 / 5 SER A 276
LYS A 275
LEU A 340
ASP A 341
 None
None
None
GDP  A1603 (-2.8A)
 1.14A 4ig1A-1p9bA:
0.0		 4ig1A-1p9bA:
19.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IJI_F_BEZF501_0
(GLUTATHIONE
S-TRANSFERASE-LIKE
PROTEIN YIBF)		 1z0f RAB14, MEMBER RAS
ONCOGENE FAMILY
(Homo
sapiens) 		4 / 8 ASN A 124
ALA A 153
SER A 154
LEU A  27
 GDP  A 200 (-3.3A)
None
GDP  A 200 (-3.7A)
None
 1.16A 4ijiF-1z0fA:
undetectable		 4ijiF-1z0fA:
22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IJI_F_BEZF501_0
(GLUTATHIONE
S-TRANSFERASE-LIKE
PROTEIN YIBF)		 2il1 RAB12
(Homo
sapiens) 		4 / 8 ASN A 251
ALA A 281
SER A 282
LEU A 154
 GDP  A 401 (-3.2A)
None
GDP  A 401 (-3.5A)
None
 1.15A 4ijiF-2il1A:
undetectable		 4ijiF-2il1A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IJI_F_BEZF501_0
(GLUTATHIONE
S-TRANSFERASE-LIKE
PROTEIN YIBF)		 5ub8 LIKELY RAB FAMILY
GTP-BINDING PROTEIN
(Candida
albicans) 		4 / 8 ASN A 128
ALA A 157
SER A 158
LEU A  31
 GDP  A 301 (-3.4A)
None
GDP  A 301 (-3.4A)
None
 1.16A 4ijiF-5ub8A:
undetectable		 4ijiF-5ub8A:
24.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JDS_C_SAMC401_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD7)		 3wgk CELL DIVISION
PROTEIN FTSZ
(Staphylococcus
aureus) 		5 / 11 ILE A  77
ALA A  71
GLY A  70
GLY A  22
ASN A  24
 None
GDP  A 400 ( 4.9A)
None
GDP  A 400 (-3.4A)
None
 1.32A 4jdsC-3wgkA:
undetectable		 4jdsC-3wgkA:
22.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JLG_A_SAMA401_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD7)		 3wgk CELL DIVISION
PROTEIN FTSZ
(Staphylococcus
aureus) 		5 / 12 ILE A  77
ALA A  71
GLY A  70
GLY A  22
ASN A  24
 None
GDP  A 400 ( 4.9A)
None
GDP  A 400 (-3.4A)
None
 1.28A 4jlgA-3wgkA:
undetectable		 4jlgA-3wgkA:
22.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JX1_F_CAMF502_0
(CAMPHOR
5-MONOOXYGENASE)		 2qag SEPTIN-2
SEPTIN-6
(Homo
sapiens;
Homo
sapiens) 		4 / 4 TYR A 258
THR A 186
VAL A 240
ILE B 189
 GDP  A 362 (-4.7A)
None
GDP  A 362 (-2.5A)
None
 1.06A 4jx1F-2qagA:
undetectable		 4jx1F-2qagA:
22.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KFJ_B_FOLB202_0
(DIHYDROFOLATE
REDUCTASE)		 5mlz DOLICHOL
MONOPHOSPHATE
MANNOSE SYNTHASE
(Pyrococcus
furiosus) 		6 / 12 ILE A   6
ALA A  72
PHE A  77
ILE A 183
LEU A 162
VAL A  87
 None
GDP  A 401 (-3.4A)
None
None
None
None
 1.37A 4kfjB-5mlzA:
undetectable		 4kfjB-5mlzA:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KM2_A_TOPA202_1
(DIHYDROFOLATE
REDUCTASE)		 1z6x ADP-RIBOSYLATION
FACTOR 4
(Homo
sapiens) 		5 / 12 ALA A  28
PHE A 124
LEU A  37
LEU A 170
ILE A  89
 GDP  A 201 (-4.1A)
None
None
None
None
 1.03A 4km2A-1z6xA:
undetectable		 4km2A-1z6xA:
22.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KM2_A_TOPA202_1
(DIHYDROFOLATE
REDUCTASE)		 3o47 ADP-RIBOSYLATION
FACTOR
GTPASE-ACTIVATING
PROTEIN 1,
ADP-RIBOSYLATION
FACTOR 1
(Homo
sapiens) 		5 / 12 ALA A 158
PHE A 254
LEU A 167
LEU A 300
ILE A 219
 GDP  A 502 (-3.9A)
None
None
None
None
 1.14A 4km2A-3o47A:
undetectable		 4km2A-3o47A:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KOS_A_4KOA201_1
(UNCHARACTERIZED
PROTEIN)		 1jny ELONGATION FACTOR
1-ALPHA
(Sulfolobus
solfataricus) 		5 / 12 PRO A 195
GLY A  18
ASN A 152
PHE A  55
LEU A  59
 GDP  A 500 (-4.3A)
GDP  A 500 (-3.2A)
GDP  A 500 (-3.2A)
None
None
 1.46A 4kosA-1jnyA:
undetectable		 4kosA-1jnyA:
17.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KOT_A_CE3A205_1
(UNCHARACTERIZED
PROTEIN)		 1jny ELONGATION FACTOR
1-ALPHA
(Sulfolobus
solfataricus) 		5 / 12 PRO A 195
GLY A  18
ASN A 152
PHE A  55
LEU A  59
 GDP  A 500 (-4.3A)
GDP  A 500 (-3.2A)
GDP  A 500 (-3.2A)
None
None
 1.48A 4kotA-1jnyA:
undetectable		 4kotA-1jnyA:
17.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KOU_A_C04A206_1
(UNCHARACTERIZED
PROTEIN)		 1jny ELONGATION FACTOR
1-ALPHA
(Sulfolobus
solfataricus) 		5 / 10 PRO A 195
GLY A  18
ASN A 152
PHE A  55
LEU A  59
 GDP  A 500 (-4.3A)
GDP  A 500 (-3.2A)
GDP  A 500 (-3.2A)
None
None
 1.43A 4kouA-1jnyA:
undetectable		 4kouA-1jnyA:
17.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KOV_A_KOVA204_1
(UNCHARACTERIZED
PROTEIN)		 1jny ELONGATION FACTOR
1-ALPHA
(Sulfolobus
solfataricus) 		5 / 12 PRO A 195
GLY A  18
ASN A 152
PHE A  55
LEU A  59
 GDP  A 500 (-4.3A)
GDP  A 500 (-3.2A)
GDP  A 500 (-3.2A)
None
None
 1.46A 4kovA-1jnyA:
0.0		 4kovA-1jnyA:
17.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KOW_A_CFXA204_1
(UNCHARACTERIZED
PROTEIN)		 1jny ELONGATION FACTOR
1-ALPHA
(Sulfolobus
solfataricus) 		5 / 12 PRO A 195
GLY A  18
ASN A 152
PHE A  55
LEU A  59
 GDP  A 500 (-4.3A)
GDP  A 500 (-3.2A)
GDP  A 500 (-3.2A)
None
None
 1.47A 4kowA-1jnyA:
undetectable		 4kowA-1jnyA:
17.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KOW_A_CFXA204_1
(UNCHARACTERIZED
PROTEIN)		 2vaw CELL DIVISION
PROTEIN FTSZ
(Pseudomonas
aeruginosa) 		5 / 12 PHE A 138
GLY A 104
MET A 105
PHE A 136
LEU A 169
 None
GDP  A1317 (-3.1A)
None
None
None
 1.26A 4kowA-2vawA:
undetectable		 4kowA-2vawA:
17.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KOX_A_CLSA205_1
(UNCHARACTERIZED
PROTEIN)		 1jny ELONGATION FACTOR
1-ALPHA
(Sulfolobus
solfataricus) 		5 / 11 PRO A 195
GLY A  18
ASN A 152
PHE A  55
LEU A  59
 GDP  A 500 (-4.3A)
GDP  A 500 (-3.2A)
GDP  A 500 (-3.2A)
None
None
 1.47A 4koxA-1jnyA:
0.0		 4koxA-1jnyA:
17.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KT0_A_PQNA2001_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1
PHOTOSYSTEM I
REACTION CENTER
SUBUNIT IX)		 3j4s FTSZ/TUBULIN-RELATED
PROTEIN
(Bacillus
thuringiensis) 		5 / 11 GLY A 140
ALA A  30
GLY A 146
ILE A  23
LEU A 270
 GDP  A 900 (-4.2A)
None
None
None
None
 0.95A 4kt0A-3j4sA:
undetectable
4kt0J-3j4sA:
undetectable		 4kt0A-3j4sA:
20.16
4kt0J-3j4sA:
6.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KYA_D_FOLD703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 4ku4 RAS-3 FROM
CRYPHONECTRIA
PARASITICA
(Cryphonectria
parasitica) 		5 / 12 VAL A 169
SER A 172
LEU A  27
VAL A 140
THR A 154
 None
GDP  A 301 (-3.2A)
None
None
None
 1.49A 4kyaD-4ku4A:
undetectable		 4kyaD-4ku4A:
15.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KYA_F_FOLF703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 4ku4 RAS-3 FROM
CRYPHONECTRIA
PARASITICA
(Cryphonectria
parasitica) 		5 / 12 VAL A 169
SER A 172
LEU A  27
VAL A 140
THR A 154
 None
GDP  A 301 (-3.2A)
None
None
None
 1.48A 4kyaF-4ku4A:
undetectable		 4kyaF-4ku4A:
15.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L4C_B_CAMB502_0
(CAMPHOR
5-MONOOXYGENASE)		 2ery RAS-RELATED PROTEIN
R-RAS2
(Homo
sapiens) 		4 / 8 LEU A  30
VAL A 164
ASP A 130
ILE A 160
 None
None
GDP  A   1 (-3.0A)
None
 0.96A 4l4cB-2eryA:
undetectable		 4l4cB-2eryA:
18.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L9Q_A_9TPA601_1
(SERUM ALBUMIN)		 5vys GDP-MANNOSE
4,6-DEHYDRATASE /
GDP-4-AMINO-4,6-DIDE
OXY-D-MANNOSE
FORMYLTRANSFERASE
(Brucella
melitensis) 		5 / 12 PRO A 228
ILE A 169
HIS A  86
ARG A  45
GLY A  15
 None
None
None
GDP  A 303 (-2.6A)
None
 1.33A 4l9qA-5vysA:
undetectable		 4l9qA-5vysA:
17.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M2X_E_TMQE202_1
(DIHYDROFOLATE
REDUCTASE)		 3tdw GENTAMICIN
RESISTANCE PROTEIN
(Enterococcus
gallinarum) 		5 / 12 ILE A 217
ASP A 200
LEU A 120
LEU A 213
ILE A 216
 GDP  A 500 ( 4.1A)
MG  A 501 ( 4.9A)
None
None
None
 1.06A 4m2xE-3tdwA:
undetectable		 4m2xE-3tdwA:
19.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MM4_B_8PRB603_2
(TRANSPORTER)		 6b9g ATLASTIN-1
(Homo
sapiens) 		3 / 3 SER B  81
MET B  84
ASP B 218
 GDP  B 401 ( 2.5A)
None
GDP  B 401 (-2.7A)
 0.82A 4mm4B-6b9gB:
undetectable		 4mm4B-6b9gB:
11.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MS4_A_2C0A501_1
(GAMMA-AMINOBUTYRIC
ACID TYPE B RECEPTOR
SUBUNIT 1)		 5igp MACROLIDE
2'-PHOSPHOTRANSFERAS
E
(Escherichia
coli) 		4 / 8 SER A 221
HIS A 205
TYR A  36
ILE A  38
 GDP  A 401 ( 4.7A)
GDP  A 401 (-4.4A)
None
GDP  A 401 (-4.2A)
 1.21A 4ms4A-5igpA:
undetectable		 4ms4A-5igpA:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MWZ_B_CQAB303_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE,
PUTATIVE)		 5w3j TUBULIN BETA CHAIN
(Saccharomyces
cerevisiae) 		4 / 8 GLY B 144
GLY B 104
GLU B 111
LEU B 112
 GDP  B 501 (-4.6A)
None
None
None
 0.69A 4mwzB-5w3jB:
undetectable		 4mwzB-5w3jB:
19.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N09_B_ADNB401_1
(ADENOSINE KINASE)		 2r6r CELL DIVISION
PROTEIN FTSZ
(Aquifex
aeolicus) 		5 / 12 GLY 1  16
GLY 1  17
ASN 1  40
GLY 1  66
ASP 1  42
 GDP  1 339 (-3.5A)
GDP  1 339 (-3.6A)
GDP  1 339 ( 4.4A)
None
None
 0.96A 4n09B-2r6r1:
8.6		 4n09B-2r6r1:
24.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N09_C_ADNC401_1
(ADENOSINE KINASE)		 2r6r CELL DIVISION
PROTEIN FTSZ
(Aquifex
aeolicus) 		5 / 12 GLY 1  16
GLY 1  17
ASN 1  40
GLY 1  66
ASP 1  42
 GDP  1 339 (-3.5A)
GDP  1 339 (-3.6A)
GDP  1 339 ( 4.4A)
None
None
 0.95A 4n09C-2r6r1:
7.9		 4n09C-2r6r1:
24.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N09_D_ADND401_1
(ADENOSINE KINASE)		 2vaw CELL DIVISION
PROTEIN FTSZ
(Pseudomonas
aeruginosa) 		5 / 12 LEU A  83
GLY A  20
GLY A 110
ALA A  82
GLY A  72
 None
GDP  A1317 (-3.4A)
GDP  A1317 (-3.2A)
None
None
 0.96A 4n09D-2vawA:
8.6		 4n09D-2vawA:
23.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N48_B_SAMB601_0
(CAP-SPECIFIC MRNA
(NUCLEOSIDE-2'-O-)-M
ETHYLTRANSFERASE 1)		 5w3j TUBULIN BETA CHAIN
(Saccharomyces
cerevisiae) 		5 / 12 ALA B  97
GLY B 109
ILE B 135
THR B 166
GLY B 144
 None
None
None
None
GDP  B 501 (-4.6A)
 1.02A 4n48B-5w3jB:
4.1		 4n48B-5w3jB:
22.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N48_B_SAMB601_1
(CAP-SPECIFIC MRNA
(NUCLEOSIDE-2'-O-)-M
ETHYLTRANSFERASE 1)		 2ik8 GUANINE
NUCLEOTIDE-BINDING
PROTEIN G(I),
ALPHA-1 SUBUNIT
(Homo
sapiens) 		4 / 5 ASN A 269
GLY A  45
ASP A 158
ASP A 150
 GDP  A 401 (-3.1A)
GDP  A 401 (-3.3A)
None
None
 1.12A 4n48B-2ik8A:
undetectable		 4n48B-2ik8A:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N48_B_SAMB601_1
(CAP-SPECIFIC MRNA
(NUCLEOSIDE-2'-O-)-M
ETHYLTRANSFERASE 1)		 4ekd GUANINE
NUCLEOTIDE-BINDING
PROTEIN G(Q) SUBUNIT
ALPHA
(Mus
musculus) 		4 / 5 ASN A 274
GLY A  51
ASP A 163
ASP A 155
 GDP  A 401 (-3.5A)
GDP  A 401 (-3.2A)
None
GDP  A 401 ( 4.8A)
 1.10A 4n48B-4ekdA:
undetectable		 4n48B-4ekdA:
23.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N49_A_SAMA601_0
(CAP-SPECIFIC MRNA
(NUCLEOSIDE-2'-O-)-M
ETHYLTRANSFERASE 1)		 3j4s FTSZ/TUBULIN-RELATED
PROTEIN
(Bacillus
thuringiensis) 		5 / 12 ALA A  30
GLY A 144
GLY A 140
THR A  93
LEU A 108
 None
None
GDP  A 900 (-4.2A)
None
None
 1.01A 4n49A-3j4sA:
undetectable		 4n49A-3j4sA:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N49_A_SAMA601_1
(CAP-SPECIFIC MRNA
(NUCLEOSIDE-2'-O-)-M
ETHYLTRANSFERASE 1)		 2ik8 GUANINE
NUCLEOTIDE-BINDING
PROTEIN G(I),
ALPHA-1 SUBUNIT
(Homo
sapiens) 		4 / 4 ASN A 269
GLY A  45
ASP A 158
ASP A 150
 GDP  A 401 (-3.1A)
GDP  A 401 (-3.3A)
None
None
 1.12A 4n49A-2ik8A:
undetectable		 4n49A-2ik8A:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N49_A_SAMA601_1
(CAP-SPECIFIC MRNA
(NUCLEOSIDE-2'-O-)-M
ETHYLTRANSFERASE 1)		 4ekd GUANINE
NUCLEOTIDE-BINDING
PROTEIN G(Q) SUBUNIT
ALPHA
(Mus
musculus) 		4 / 4 ASN A 274
GLY A  51
ASP A 163
ASP A 155
 GDP  A 401 (-3.5A)
GDP  A 401 (-3.2A)
None
GDP  A 401 ( 4.8A)
 1.09A 4n49A-4ekdA:
undetectable		 4n49A-4ekdA:
23.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NC3_A_ERMA1202_1
(CHIMERA PROTEIN OF
HUMAN
5-HYDROXYTRYPTAMINE
RECEPTOR 2B AND E.
COLI SOLUBLE
CYTOCHROME B562)		 2x77 ADP-RIBOSYLATION
FACTOR
(Leishmania
major) 		5 / 12 LEU A  37
SER A 163
MET A 173
PHE A 127
VAL A  94
 None
GDP  A 188 (-4.2A)
None
None
None
 1.26A 4nc3A-2x77A:
undetectable		 4nc3A-2x77A:
18.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NJJ_A_SAMA302_0
(7-CARBOXY-7-DEAZAGUA
NINE SYNTHASE)		 1moz ADP-RIBOSYLATION
FACTOR-LIKE PROTEIN
1
(Saccharomyces
cerevisiae) 		5 / 12 ASP A  68
THR A  45
GLU A  55
ASN A  65
ASP A  27
 GDP  A 184 (-3.5A)
None
None
None
None
 1.36A 4njjA-1mozA:
1.6		 4njjA-1mozA:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NJK_A_SAMA302_0
(7-CARBOXY-7-DEAZAGUA
NINE SYNTHASE)		 1moz ADP-RIBOSYLATION
FACTOR-LIKE PROTEIN
1
(Saccharomyces
cerevisiae) 		5 / 12 ASP A  68
THR A  45
GLU A  55
ASN A  65
ASP A  27
 GDP  A 184 (-3.5A)
None
None
None
None
 1.37A 4njkA-1mozA:
1.5		 4njkA-1mozA:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NJK_B_SAMB302_0
(7-CARBOXY-7-DEAZAGUA
NINE SYNTHASE)		 1moz ADP-RIBOSYLATION
FACTOR-LIKE PROTEIN
1
(Saccharomyces
cerevisiae) 		5 / 12 ASP A  68
THR A  45
GLU A  55
ASN A  65
ASP A  27
 GDP  A 184 (-3.5A)
None
None
None
None
 1.35A 4njkB-1mozA:
1.4		 4njkB-1mozA:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O1Z_B_MXMB807_1
(PROSTAGLANDIN G/H
SYNTHASE 1)		 4fid G PROTEIN ALPHA
SUBUNIT
(Entamoeba
histolytica) 		5 / 12 LEU A  43
ILE A 207
VAL A 209
LEU A  28
ALA A 327
 None
None
None
None
GDP  A 401 (-3.2A)
 1.10A 4o1zB-4fidA:
undetectable		 4o1zB-4fidA:
20.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O8F_A_BRLA501_2
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 2ht6 GTP-BINDING PROTEIN
GEM
(Homo
sapiens) 		4 / 5 GLY A  87
LEU A 129
LEU A 231
LEU A 171
 GDP  A 545 (-3.3A)
None
None
None
 0.84A 4o8fA-2ht6A:
undetectable		 4o8fA-2ht6A:
17.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OAD_A_CLMA205_0
(GNAT SUPERFAMILY
ACETYLTRANSFERASE
PA4794)		 2e87 HYPOTHETICAL PROTEIN
PH1320
(Pyrococcus
horikoshii) 		5 / 12 PRO A 176
CYH A 260
ASN A 288
ALA A 317
LEU A 318
 None
None
GDP  A 400 (-3.3A)
GDP  A 400 (-3.7A)
GDP  A 400 (-4.0A)
 1.37A 4oadA-2e87A:
undetectable		 4oadA-2e87A:
16.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OAD_A_CLMA205_0
(GNAT SUPERFAMILY
ACETYLTRANSFERASE
PA4794)		 3r4v PUTATIVE
UNCHARACTERIZED
PROTEIN
(Pseudomonas
phage
201phi2-1) 		5 / 12 PHE A   9
ASN A 155
ALA A 120
GLY A 119
LEU A  90
 None
GDP  A 400 (-3.1A)
GDP  A 400 (-3.4A)
None
None
 1.44A 4oadA-3r4vA:
undetectable		 4oadA-3r4vA:
19.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OT2_A_NPSA602_1
(SERUM ALBUMIN)		 5w75 ELONGATION FACTOR TU
(Thermotoga
neapolitana) 		4 / 6 ALA A  30
ASP A  81
LEU A 179
SER A 174
 None
MG  A 402 ( 4.0A)
None
GDP  A 401 (-3.0A)
 1.11A 4ot2A-5w75A:
undetectable		 4ot2A-5w75A:
9.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OT2_A_NPSA602_1
(SERUM ALBUMIN)		 5w7q CONSENSUS ELONGATION
FACTOR
(synthetic
construct) 		4 / 6 ALA A  30
ASP A  81
LEU A 179
SER A 174
 None
GDP  A 402 ( 4.8A)
None
GDP  A 402 (-2.9A)
 1.11A 4ot2A-5w7qA:
undetectable		 4ot2A-5w7qA:
9.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P3R_A_FOLA201_1
(DIHYDROFOLATE
REDUCTASE)		 1zca G ALPHA I/12
(Mus
musculus) 		3 / 3 ASP A 297
ARG A 168
THR A 350
 GDP  A 382 (-3.1A)
None
GDP  A 382 (-3.7A)
 0.88A 4p3rA-1zcaA:
undetectable		 4p3rA-1zcaA:
18.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QB9_D_PARD500_1
(ENHANCED
INTRACELLULAR
SURVIVAL PROTEIN)		 3cph RAS-RELATED PROTEIN
SEC4
(Saccharomyces
cerevisiae) 		4 / 8 PHE A  45
SER A  48
THR A  52
ASP A  75
 GDP  A 302 (-4.4A)
None
None
MG  A 301 ( 4.1A)
 1.11A 4qb9D-3cphA:
undetectable		 4qb9D-3cphA:
17.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QLF_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 1u0l PROBABLE GTPASE ENGC
(Thermotoga
maritima) 		5 / 11 ILE A 154
ALA A 148
LEU A 180
ILE A  83
LEU A 161
 None
GDP  A 299 (-3.5A)
None
None
None
 1.20A 4qlfA-1u0lA:
undetectable		 4qlfA-1u0lA:
18.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QZU_A_RTLA201_0
(RETINOL-BINDING
PROTEIN 2)		 5xc3 PROBABLE RAB-RELATED
GTPASE
(Acanthamoeba
polyphaga
mimivirus) 		5 / 12 PHE A 161
ILE A   8
VAL A  16
LEU A  10
LEU A 160
 None
None
GDP  A1200 (-4.0A)
None
None
 1.35A 4qzuA-5xc3A:
undetectable		 4qzuA-5xc3A:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R1Z_B_AERB601_1
(CYP17A1 PROTEIN)		 3zbq PHIKZ039
(Pseudomonas
virus
phiKZ) 		4 / 7 SER A 144
GLY A 106
ALA A 107
THR A 111
 None
GDP  A 999 (-3.4A)
GDP  A 999 (-3.8A)
None
 0.86A 4r1zB-3zbqA:
undetectable		 4r1zB-3zbqA:
20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R20_B_AERB602_1
(CYTOCHROME P450
FAMILY 17
POLYPEPTIDE 2)		 4ku4 RAS-3 FROM
CRYPHONECTRIA
PARASITICA
(Cryphonectria
parasitica) 		5 / 9 ASN A 142
VAL A 140
GLY A  23
THR A  28
VAL A  87
 GDP  A 301 (-3.2A)
None
GDP  A 301 (-3.1A)
None
None
 1.26A 4r20B-4ku4A:
undetectable		 4r20B-4ku4A:
19.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R29_D_SAMD301_0
(UNCHARACTERIZED
PROTEIN)		 1ofu CELL DIVISION
PROTEIN FTSZ
(Pseudomonas
aeruginosa) 		5 / 12 ALA A  71
GLY A  20
ILE A 151
MET A 105
GLY A 106
 GDP  A1318 ( 4.8A)
GDP  A1318 (-3.5A)
None
None
GDP  A1318 ( 4.3A)
 1.00A 4r29D-1ofuA:
0.0		 4r29D-1ofuA:
20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RTM_A_SAMA301_0
(DNA ADENINE
METHYLASE)		 5cju ISOBUTYRYL-COA
MUTASE FUSED
(Cupriavidus
metallidurans) 		5 / 12 GLY A 216
GLY A 219
ALA A 220
PRO A 250
GLN A  51
 None
GDP  A1104 (-3.2A)
GDP  A1104 (-4.8A)
None
None
 0.97A 4rtmA-5cjuA:
undetectable		 4rtmA-5cjuA:
14.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RYA_A_MTLA501_0
(ABC TRANSPORTER
SUBSTRATE BINDING
PROTEIN (SORBITOL))		 1xje RIBONUCLEOTIDE
REDUCTASE,
B12-DEPENDENT
(Thermotoga
maritima) 		5 / 12 ASN A 372
GLY A 160
PHE A 374
ALA A 332
VAL A 383
 None
GDP  A1002 ( 4.7A)
None
None
None
 1.47A 4ryaA-1xjeA:
undetectable		 4ryaA-1xjeA:
22.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4U9U_A_ACTA1502_0
(NA(+)-TRANSLOCATING
NADH-QUINONE
REDUCTASE SUBUNIT F)		 2vaw CELL DIVISION
PROTEIN FTSZ
(Pseudomonas
aeruginosa) 		4 / 5 GLY A 112
ALA A 113
GLY A 108
PRO A  75
 None
None
GDP  A1317 (-3.4A)
None
 0.96A 4u9uA-2vawA:
5.0		 4u9uA-2vawA:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4U9U_B_ACTB1502_0
(NA(+)-TRANSLOCATING
NADH-QUINONE
REDUCTASE SUBUNIT F)		 2vaw CELL DIVISION
PROTEIN FTSZ
(Pseudomonas
aeruginosa) 		4 / 5 GLY A 112
ALA A 113
GLY A 108
PRO A  75
 None
None
GDP  A1317 (-3.4A)
None
 0.98A 4u9uB-2vawA:
3.5		 4u9uB-2vawA:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UBE_A_2FAA401_2
(ADENOSINE KINASE)		 5d3q DYNAMIN-1,DYNAMIN-1
(Homo
sapiens) 		4 / 4 ALA A 251
VAL A 235
GLY A 273
THR A 274
 None
GDP  A 801 (-4.0A)
None
None
 1.12A 4ubeA-5d3qA:
undetectable		 4ubeA-5d3qA:
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UCK_A_SAMA2409_0
(RNA-DIRECTED RNA
POLYMERASE L)		 1shz GUANINE
NUCLEOTIDE-BINDING
PROTEIN
GALPHA(13):GALPHA(I1
) CHIMERA
(Mus
musculus;
Rattus
norvegicus) 		6 / 12 GLY A  60
GLY A  57
GLY A 225
SER A  59
ALA A 348
THR A 349
 GDP  A 475 (-3.2A)
ALF  A 378 (-3.3A)
ALF  A 378 (-3.2A)
GDP  A 475 (-3.4A)
GDP  A 475 (-3.5A)
GDP  A 475 (-3.8A)
 1.35A 4uckA-1shzA:
undetectable		 4uckA-1shzA:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UCK_A_SAMA2409_0
(RNA-DIRECTED RNA
POLYMERASE L)		 2ik8 GUANINE
NUCLEOTIDE-BINDING
PROTEIN G(I),
ALPHA-1 SUBUNIT
(Homo
sapiens) 		6 / 12 GLY A  45
GLY A  42
GLY A 203
SER A  44
ALA A 326
THR A 327
 GDP  A 401 (-3.3A)
ALF  A 355 (-3.3A)
ALF  A 355 (-3.3A)
GDP  A 401 (-3.6A)
GDP  A 401 (-3.2A)
GDP  A 401 (-3.3A)
 1.40A 4uckA-2ik8A:
undetectable		 4uckA-2ik8A:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UCK_A_SAMA2409_0
(RNA-DIRECTED RNA
POLYMERASE L)		 3c7k GUANINE
NUCLEOTIDE-BINDING
PROTEIN G(O) SUBUNIT
ALPHA
(Mus
musculus) 		6 / 12 GLY A  45
GLY A  42
GLY A 204
SER A  44
ALA A 326
THR A 327
 GDP  A 361 (-2.8A)
ALF  A 365 (-3.0A)
ALF  A 365 (-3.2A)
GDP  A 361 (-4.0A)
GDP  A 361 (-3.4A)
GDP  A 361 (-3.4A)
 1.30A 4uckA-3c7kA:
undetectable		 4uckA-3c7kA:
22.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UCK_A_SAMA2409_0
(RNA-DIRECTED RNA
POLYMERASE L)		 3cx6 GUANINE
NUCLEOTIDE-BINDING
PROTEIN ALPHA-13
SUBUNIT
(Mus
musculus) 		6 / 12 GLY A  60
GLY A  57
GLY A 225
SER A  59
ALA A 349
THR A 348
 GDP  A 775 (-3.2A)
GDP  A 775 ( 4.2A)
None
GDP  A 775 (-3.4A)
GDP  A 775 (-3.2A)
GDP  A 775 (-3.8A)
 1.43A 4uckA-3cx6A:
undetectable		 4uckA-3cx6A:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UCK_A_SAMA2409_0
(RNA-DIRECTED RNA
POLYMERASE L)		 4ekd GUANINE
NUCLEOTIDE-BINDING
PROTEIN G(Q) SUBUNIT
ALPHA
(Mus
musculus) 		6 / 12 GLY A  51
GLY A  48
GLY A 208
SER A  50
ALA A 331
THR A 332
 GDP  A 401 (-3.2A)
ALF  A 402 (-2.9A)
ALF  A 402 (-3.1A)
GDP  A 401 (-3.9A)
GDP  A 401 (-3.2A)
GDP  A 401 (-3.6A)
 1.41A 4uckA-4ekdA:
undetectable		 4uckA-4ekdA:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UW0_A_SAMA1506_0
(WBDD)		 1z6x ADP-RIBOSYLATION
FACTOR 4
(Homo
sapiens) 		5 / 12 GLY A  29
ALA A  27
ILE A  33
VAL A  91
ILE A  89
 GDP  A 201 (-3.0A)
GDP  A 201 (-4.1A)
None
None
None
 0.93A 4uw0A-1z6xA:
undetectable		 4uw0A-1z6xA:
16.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UW0_A_SAMA1506_0
(WBDD)		 3aq4 ADP-RIBOSYLATION
FACTOR 1
(Arabidopsis
thaliana) 		5 / 12 GLY A  29
ALA A  27
ILE A  33
VAL A  91
ILE A  89
 GDP  A 183 (-3.3A)
GDP  A 183 (-4.3A)
None
None
None
 0.96A 4uw0A-3aq4A:
undetectable		 4uw0A-3aq4A:
16.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UW0_A_SAMA1506_0
(WBDD)		 3lrp ADP-RIBOSYLATION
FACTOR 1
(Plasmodium
falciparum) 		5 / 12 GLY A  29
ALA A  27
ILE A  33
VAL A  91
ILE A  89
 GDP  A 182 (-3.1A)
GDP  A 182 (-4.3A)
None
None
None
 0.97A 4uw0A-3lrpA:
2.5		 4uw0A-3lrpA:
15.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UW0_A_SAMA1506_0
(WBDD)		 3lvr ARF-GAP WITH SH3
DOMAIN, ANK REPEAT
AND PH
DOMAIN-CONTAINING
PROTEIN 3,
ADP-RIBOSYLATION
FACTOR 6
(Homo
sapiens;
synthetic
construct) 		5 / 12 GLY E  25
ALA E  23
ILE E  29
VAL E  87
ILE E  85
 GDP  E 737 (-3.2A)
GDP  E 737 ( 4.4A)
None
None
None
 1.00A 4uw0A-3lvrE:
2.2		 4uw0A-3lvrE:
22.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UW0_A_SAMA1506_0
(WBDD)		 3o47 ADP-RIBOSYLATION
FACTOR
GTPASE-ACTIVATING
PROTEIN 1,
ADP-RIBOSYLATION
FACTOR 1
(Homo
sapiens) 		5 / 12 GLY A 159
ALA A 157
ILE A 163
VAL A 221
ILE A 219
 GDP  A 502 (-3.2A)
GDP  A 502 (-4.4A)
None
None
None
 0.94A 4uw0A-3o47A:
2.1		 4uw0A-3o47A:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UW0_A_SAMA1506_0
(WBDD)		 4ylg ADP-RIBOSYLATION
FACTOR
(Entamoeba
histolytica) 		5 / 12 GLY A  25
ALA A  23
ILE A  29
VAL A  87
ILE A  85
 GDP  A 201 (-3.3A)
GDP  A 201 (-4.2A)
None
None
None
 0.95A 4uw0A-4ylgA:
undetectable		 4uw0A-4ylgA:
15.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UW0_A_SAMA1506_0
(WBDD)		 5uf8 POTENTIAL
ADP-RIBOSYLATION
FACTOR
(Candida
albicans) 		5 / 12 GLY A  29
ALA A  27
ILE A  33
VAL A  91
ILE A  89
 GDP  A 500 (-3.2A)
GDP  A 500 (-4.2A)
None
None
None
 0.94A 4uw0A-5uf8A:
undetectable		 4uw0A-5uf8A:
16.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V3Y_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 4oro POLYMERASE PB2
(Influenza
B
virus) 		4 / 8 PHE A 365
SER A 407
ARG A 334
TRP A 359
 None
None
GDP  A 501 (-4.1A)
GDP  A 501 (-3.3A)
 1.16A 4v3yA-4oroA:
undetectable
4v3yB-4oroA:
undetectable		 4v3yA-4oroA:
18.21
4v3yB-4oroA:
18.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4W9N_C_CCSC1548_0
(ENOYL-[ACYL-CARRIER-
PROTEIN] REDUCTASE)		 5igp MACROLIDE
2'-PHOSPHOTRANSFERAS
E
(Escherichia
coli) 		3 / 3 ALA A  93
TRP A  49
VAL A  50
 None
None
GDP  A 401 (-4.6A)
 0.25A 4w9nC-5igpA:
undetectable		 4w9nC-5igpA:
24.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WNV_D_QI9D602_0
(CYTOCHROME P450 2D6)		 3r4v PUTATIVE
UNCHARACTERIZED
PROTEIN
(Pseudomonas
phage
201phi2-1) 		4 / 7 GLU A 167
SER A 163
VAL A 118
PHE A 116
 None
None
GDP  A 400 (-4.6A)
None
 1.04A 4wnvD-3r4vA:
undetectable		 4wnvD-3r4vA:
20.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X61_A_SAMA701_0
(PROTEIN ARGININE
N-METHYLTRANSFERASE
5)		 4b46 CELL DIVISION
PROTEIN FTSZ
(Haloferax
volcanii) 		5 / 12 GLY A 135
GLY A 106
PRO A 138
LEU A 137
LEU A 164
 None
GDP  A1368 (-3.6A)
GDP  A1368 (-4.2A)
None
None
 1.13A 4x61A-4b46A:
undetectable		 4x61A-4b46A:
22.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X61_A_SAMA701_1
(PROTEIN ARGININE
N-METHYLTRANSFERASE
5)		 4wnr LEUCINE-RICH-REPEAT
PROTEIN
(Methanosarcina
barkeri) 		4 / 5 TYR A 563
TYR A 597
GLU A 381
ASP A 376
 None
None
None
GDP  A 701 ( 4.6A)
 1.44A 4x61A-4wnrA:
1.7		 4x61A-4wnrA:
20.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XDT_A_ACTA406_0
(FAD:PROTEIN FMN
TRANSFERASE)		 1p9b ADENYLOSUCCINATE
SYNTHETASE
(Plasmodium
falciparum) 		4 / 5 SER A 276
LYS A 275
LEU A 340
ASP A 341
 None
None
None
GDP  A1603 (-2.8A)
 1.13A 4xdtA-1p9bA:
0.0		 4xdtA-1p9bA:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XE5_A_OBNA1104_1
(SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1)		 2r6r CELL DIVISION
PROTEIN FTSZ
(Aquifex
aeolicus) 		5 / 12 GLU 1  28
ASP 1 183
LEU 1 186
GLY 1  14
ALA 1  99
 None
GDP  1 339 (-3.2A)
None
None
None
 1.23A 4xe5A-2r6r1:
undetectable		 4xe5A-2r6r1:
17.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YOA_A_017A100_1
(HIV-1 PROTEASE)		 4j0q ELONGATION FACTOR
TU-A
(Pseudomonas
putida) 		4 / 6 ASN A 136
ASP A  22
THR A  17
VAL A 105
 GDP  A 402 (-3.4A)
GDP  A 402 (-3.7A)
None
None
 1.07A 4yoaA-4j0qA:
undetectable		 4yoaA-4j0qA:
15.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YOA_A_017A100_1
(HIV-1 PROTEASE)		 4j0q ELONGATION FACTOR
TU-A
(Pseudomonas
putida) 		4 / 6 ASN A 136
ASP A 110
THR A  17
VAL A 105
 GDP  A 402 (-3.4A)
None
None
None
 1.12A 4yoaA-4j0qA:
undetectable		 4yoaA-4j0qA:
15.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YOA_A_017A100_1
(HIV-1 PROTEASE)		 4zv4 ELONGATION FACTOR TU
(Pseudomonas
aeruginosa) 		4 / 6 ASN A 136
ASP A 110
THR A  17
VAL A 105
 GDP  A 501 (-3.6A)
None
None
None
 0.98A 4yoaA-4zv4A:
1.9		 4yoaA-4zv4A:
15.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YVG_A_SAMA301_0
(TRNA
(GUANINE-N(1)-)-METH
YLTRANSFERASE)		 3zbq PHIKZ039
(Pseudomonas
virus
phiKZ) 		5 / 12 GLY A  16
GLU A  21
GLY A  20
GLY A  14
GLY A  13
 None
None
None
GDP  A 999 (-3.3A)
GDP  A 999 (-3.6A)
 0.86A 4yvgA-3zbqA:
undetectable		 4yvgA-3zbqA:
22.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z7F_B_FOLB201_0
(FOLATE ECF
TRANSPORTER)		 3zf8 MANNAN POLYMERASE
COMPLEXES SUBUNIT
MNN9
(Saccharomyces
cerevisiae) 		5 / 12 ALA A 166
PHE A 148
THR A 150
ASN A 236
THR A 121
 None
None
None
GDP  A1395 (-3.5A)
None
 1.31A 4z7fB-3zf8A:
0.9		 4z7fB-3zf8A:
19.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z7F_E_FOLE201_0
(FOLATE ECF
TRANSPORTER)		 3zf8 MANNAN POLYMERASE
COMPLEXES SUBUNIT
MNN9
(Saccharomyces
cerevisiae) 		5 / 9 ALA A 166
PHE A 148
THR A 150
ASN A 236
THR A 121
 None
None
None
GDP  A1395 (-3.5A)
None
 1.39A 4z7fE-3zf8A:
1.0		 4z7fE-3zf8A:
19.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z90_E_4LEE401_1
(GAMMA-AMINOBUTYRIC-A
CID RECEPTOR SUBUNIT
BETA-1)		 4aii GTP-BINDING PROTEIN
REM 2
(Rattus
norvegicus) 		5 / 7 THR A 259
THR A 267
LEU A 270
THR A 134
THR A 130
 None
None
None
None
GDP  A1284 (-3.4A)
 1.18A 4z90A-4aiiA:
undetectable
4z90B-4aiiA:
undetectable
4z90C-4aiiA:
undetectable
4z90D-4aiiA:
undetectable
4z90E-4aiiA:
undetectable		 4z90A-4aiiA:
18.27
4z90B-4aiiA:
18.27
4z90C-4aiiA:
18.27
4z90D-4aiiA:
18.27
4z90E-4aiiA:
18.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZVM_B_DM2B303_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 1xje RIBONUCLEOTIDE
REDUCTASE,
B12-DEPENDENT
(Thermotoga
maritima) 		5 / 11 VAL A 136
PHE A 374
GLY A 161
GLY A 160
ASN A  96
 None
None
GDP  A1002 (-4.4A)
GDP  A1002 ( 4.7A)
None
 1.41A 4zvmA-1xjeA:
undetectable
4zvmB-1xjeA:
undetectable		 4zvmA-1xjeA:
16.06
4zvmB-1xjeA:
16.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZVM_B_DM2B303_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 1xje RIBONUCLEOTIDE
REDUCTASE,
B12-DEPENDENT
(Thermotoga
maritima) 		5 / 11 VAL A 137
PHE A 374
GLY A 161
GLY A 160
ASN A  96
 None
None
GDP  A1002 (-4.4A)
GDP  A1002 ( 4.7A)
None
 1.37A 4zvmA-1xjeA:
undetectable
4zvmB-1xjeA:
undetectable		 4zvmA-1xjeA:
16.06
4zvmB-1xjeA:
16.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZVM_B_DM2B303_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 3zbq PHIKZ039
(Pseudomonas
virus
phiKZ) 		5 / 11 VAL A 178
GLN A 175
GLY A  16
GLY A  13
ASN A  39
 GDP  A 999 (-4.2A)
GDP  A 999 (-3.7A)
None
GDP  A 999 (-3.6A)
None
 1.37A 4zvmA-3zbqA:
5.1
4zvmB-3zbqA:
5.4		 4zvmA-3zbqA:
17.46
4zvmB-3zbqA:
17.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A5Z_C_WJZC304_0
(BETA-LACTAMASE NDM-1)		 3jb9 PRE-MRNA-SPLICING
FACTOR CWF10
(Schizosaccharomy
ces
pombe) 		4 / 7 MET B 597
LYS B 154
GLY B 219
ASN B 250
 None
GDP  B1000 ( 3.5A)
GDP  B1000 ( 4.7A)
None
 1.29A 5a5zC-3jb9B:
undetectable		 5a5zC-3jb9B:
13.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ADL_B_H4BB600_1
(ENDOTHELIAL NITRIC
OXIDE SYNTHASE)		 4oro POLYMERASE PB2
(Influenza
B
virus) 		4 / 7 PHE A 365
SER A 407
ARG A 334
TRP A 359
 None
None
GDP  A 501 (-4.1A)
GDP  A 501 (-3.3A)
 1.25A 5adlA-4oroA:
undetectable
5adlB-4oroA:
undetectable		 5adlA-4oroA:
18.69
5adlB-4oroA:
18.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ALB_L_TIQL1210_2
(MEDI2452 LIGHT CHAIN)		 2j3e T7I23.11 PROTEIN
(Arabidopsis
thaliana) 		4 / 8 SER A  51
GLY A  48
ALA A  69
GLY A  45
 GDP  A1251 (-3.0A)
GDP  A1251 (-2.8A)
None
GDP  A1251 ( 4.5A)
 0.91A 5albL-2j3eA:
undetectable		 5albL-2j3eA:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BS8_G_MFXG101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
TTACGTGCATAGTCATTCAT
GACC)		 2atv RAS-LIKE
ESTROGEN-REGULATED
GROWTH INHIBITOR
(Homo
sapiens) 		4 / 7 ALA A 149
ARG A  14
GLY A  13
GLU A  94
 GDP  A 415 (-3.7A)
None
None
None
 0.88A 5bs8A-2atvA:
undetectable
5bs8C-2atvA:
undetectable
5bs8D-2atvA:
3.7		 5bs8A-2atvA:
17.43
5bs8C-2atvA:
17.43
5bs8D-2atvA:
24.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BS8_H_MFXH101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
GGTCATGAATGACTATGCAC
GTAA)		 1z0a RAS-RELATED PROTEIN
RAB-2A
(Homo
sapiens) 		4 / 7 ALA A 159
ASP A  61
GLY A  13
GLU A  66
 None
MG  A1201 (-3.0A)
None
GDP  A1200 ( 4.8A)
 0.99A 5bs8A-1z0aA:
undetectable
5bs8B-1z0aA:
3.9
5bs8C-1z0aA:
undetectable		 5bs8A-1z0aA:
14.51
5bs8B-1z0aA:
24.80
5bs8C-1z0aA:
14.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BS8_H_MFXH101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
GGTCATGAATGACTATGCAC
GTAA)		 5ub8 LIKELY RAB FAMILY
GTP-BINDING PROTEIN
(Candida
albicans) 		4 / 7 ALA A 157
ASP A  70
GLY A  22
GLU A  75
 None
ZN  A 302 ( 3.9A)
None
GDP  A 301 ( 4.8A)
 0.82A 5bs8A-5ub8A:
undetectable
5bs8B-5ub8A:
3.7
5bs8C-5ub8A:
undetectable		 5bs8A-5ub8A:
19.14
5bs8B-5ub8A:
21.19
5bs8C-5ub8A:
19.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BS8_H_MFXH101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
GGTCATGAATGACTATGCAC
GTAA)		 5xc3 PROBABLE RAB-RELATED
GTPASE
(Acanthamoeba
polyphaga
mimivirus) 		4 / 7 ALA A 149
ASP A  61
GLY A  12
GLU A  66
 None
MG  A1201 ( 4.0A)
None
GDP  A1200 ( 4.7A)
 0.89A 5bs8A-5xc3A:
undetectable
5bs8B-5xc3A:
3.1
5bs8C-5xc3A:
undetectable		 5bs8A-5xc3A:
14.71
5bs8B-5xc3A:
20.40
5bs8C-5xc3A:
14.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BTD_E_GFNE101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
GGTCATGAATGACTATGCAC
GTAA)		 5ub8 LIKELY RAB FAMILY
GTP-BINDING PROTEIN
(Candida
albicans) 		4 / 7 ALA A 157
ASP A  70
GLY A  22
GLU A  75
 None
ZN  A 302 ( 3.9A)
None
GDP  A 301 ( 4.8A)
 0.84A 5btdA-5ub8A:
undetectable
5btdB-5ub8A:
3.6
5btdC-5ub8A:
undetectable		 5btdA-5ub8A:
19.14
5btdB-5ub8A:
21.19
5btdC-5ub8A:
19.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BTD_G_GFNG101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
TTACGTGCATAGTCATTCAT
GACC)		 5ub8 LIKELY RAB FAMILY
GTP-BINDING PROTEIN
(Candida
albicans) 		4 / 7 ALA A 157
ASP A  70
GLY A  22
GLU A  75
 None
ZN  A 302 ( 3.9A)
None
GDP  A 301 ( 4.8A)
 0.87A 5btdA-5ub8A:
undetectable
5btdC-5ub8A:
undetectable
5btdD-5ub8A:
3.2		 5btdA-5ub8A:
19.14
5btdC-5ub8A:
19.14
5btdD-5ub8A:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BTG_E_LFXE101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
GGTCATGAATGACTATGCAC
GTAA)		 2atv RAS-LIKE
ESTROGEN-REGULATED
GROWTH INHIBITOR
(Homo
sapiens) 		4 / 6 ALA A 149
ARG A  14
GLY A  13
GLU A  94
 GDP  A 415 (-3.7A)
None
None
None
 0.88A 5btgA-2atvA:
undetectable
5btgB-2atvA:
4.0
5btgC-2atvA:
undetectable		 5btgA-2atvA:
17.43
5btgB-2atvA:
24.06
5btgC-2atvA:
17.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5C0O_E_SAME301_0
(TRNA
(ADENINE(58)-N(1))-M
ETHYLTRANSFERASE
TRMI)		 1r5n EUKARYOTIC PEPTIDE
CHAIN RELEASE FACTOR
GTP-BINDING SUBUNIT
(Schizosaccharomy
ces
pombe) 		5 / 12 ALA A 277
GLY A 256
GLY A 250
LEU A 254
LEU A 259
 None
None
GDP  A 663 (-2.9A)
None
None
 1.15A 5c0oE-1r5nA:
undetectable		 5c0oE-1r5nA:
19.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5C0O_G_SAMG301_0
(TRNA
(ADENINE(58)-N(1))-M
ETHYLTRANSFERASE
TRMI)		 4b46 CELL DIVISION
PROTEIN FTSZ
(Haloferax
volcanii) 		5 / 12 ALA A  11
GLY A 108
GLY A 106
GLY A 135
ALA A  70
 GDP  A1368 (-3.3A)
GDP  A1368 ( 3.8A)
GDP  A1368 (-3.6A)
None
None
 1.00A 5c0oG-4b46A:
3.0		 5c0oG-4b46A:
22.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5D4U_A_SAMA301_0
(UNCHARACTERIZED
PROTEIN MJ0489)		 2r6r CELL DIVISION
PROTEIN FTSZ
(Aquifex
aeolicus) 		5 / 12 GLY 1  74
ILE 1  57
THR 1 105
GLY 1  16
GLY 1 146
 None
None
GDP  1 339 (-4.3A)
GDP  1 339 (-3.5A)
None
 1.05A 5d4uA-2r6r1:
3.7		 5d4uA-2r6r1:
22.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5D4U_A_SAMA301_0
(UNCHARACTERIZED
PROTEIN MJ0489)		 3wgk CELL DIVISION
PROTEIN FTSZ
(Staphylococcus
aureus) 		5 / 12 GLY A  78
ILE A  61
THR A 109
GLY A  20
GLY A 150
 None
None
GDP  A 400 (-3.3A)
GDP  A 400 (-3.5A)
None
 0.96A 5d4uA-3wgkA:
3.5		 5d4uA-3wgkA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5D4U_B_SAMB301_0
(UNCHARACTERIZED
PROTEIN MJ0489)		 2r6r CELL DIVISION
PROTEIN FTSZ
(Aquifex
aeolicus) 		5 / 12 GLY 1  74
ILE 1  57
THR 1 105
GLY 1  16
GLY 1 146
 None
None
GDP  1 339 (-4.3A)
GDP  1 339 (-3.5A)
None
 1.05A 5d4uB-2r6r1:
3.7		 5d4uB-2r6r1:
22.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5D4U_B_SAMB301_0
(UNCHARACTERIZED
PROTEIN MJ0489)		 3wgk CELL DIVISION
PROTEIN FTSZ
(Staphylococcus
aureus) 		5 / 12 GLY A  78
ILE A  61
THR A 109
GLY A  20
GLY A 150
 None
None
GDP  A 400 (-3.3A)
GDP  A 400 (-3.5A)
None
 0.97A 5d4uB-3wgkA:
3.6		 5d4uB-3wgkA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5D4U_C_SAMC301_0
(UNCHARACTERIZED
PROTEIN MJ0489)		 3wgk CELL DIVISION
PROTEIN FTSZ
(Staphylococcus
aureus) 		5 / 12 GLY A  78
ILE A  61
THR A 109
GLY A  20
GLY A 150
 None
None
GDP  A 400 (-3.3A)
GDP  A 400 (-3.5A)
None
 0.99A 5d4uC-3wgkA:
undetectable		 5d4uC-3wgkA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5D4U_D_SAMD301_0
(UNCHARACTERIZED
PROTEIN MJ0489)		 2r6r CELL DIVISION
PROTEIN FTSZ
(Aquifex
aeolicus) 		5 / 12 GLY 1  74
ILE 1  57
THR 1 105
GLY 1  16
GLY 1 146
 None
None
GDP  1 339 (-4.3A)
GDP  1 339 (-3.5A)
None
 1.01A 5d4uD-2r6r1:
undetectable		 5d4uD-2r6r1:
22.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5D4U_D_SAMD301_0
(UNCHARACTERIZED
PROTEIN MJ0489)		 3wgk CELL DIVISION
PROTEIN FTSZ
(Staphylococcus
aureus) 		5 / 12 GLY A  78
ILE A  61
THR A 109
GLY A  20
GLY A 150
 None
None
GDP  A 400 (-3.3A)
GDP  A 400 (-3.5A)
None
 0.92A 5d4uD-3wgkA:
undetectable		 5d4uD-3wgkA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DQF_A_CZEA613_1
(SERUM ALBUMIN)		 5fg3 PROBABLE TRANSLATION
INITIATION FACTOR
IF-2
(Aeropyrum
pernix) 		5 / 9 ALA A 139
ASP A 113
GLY A  28
LEU A  32
LEU A 219
 None
None
GDP  A 701 (-3.3A)
None
None
 1.20A 5dqfA-5fg3A:
undetectable		 5dqfA-5fg3A:
23.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DQF_A_CZEA613_1
(SERUM ALBUMIN)		 5yt0 PROBABLE TRANSLATION
INITIATION FACTOR
IF-2
(Aeropyrum
pernix) 		5 / 9 ALA A 139
ASP A 113
GLY A  28
LEU A  32
LEU A 219
 None
None
GDP  A 500 (-3.4A)
None
None
 1.20A 5dqfA-5yt0A:
undetectable		 5dqfA-5yt0A:
10.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E26_A_PAUA602_0
(PANTOTHENATE KINASE
2, MITOCHONDRIAL)		 5i67 PHOSPHOENOLPYRUVATE
CARBOXYKINASE [GTP]
(Mycobacterium
tuberculosis) 		4 / 7 GLY A 417
SER A 273
GLY A 274
ALA A 268
 None
None
GDP  A 701 (-3.2A)
None
 0.86A 5e26A-5i67A:
undetectable
5e26B-5i67A:
undetectable		 5e26A-5i67A:
22.24
5e26B-5i67A:
22.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E26_B_PAUB601_0
(PANTOTHENATE KINASE
2, MITOCHONDRIAL)		 1xje RIBONUCLEOTIDE
REDUCTASE,
B12-DEPENDENT
(Thermotoga
maritima) 		4 / 7 ALA A 210
GLU A 324
GLY A 162
GLY A 164
 GDP  A1002 (-3.4A)
GDP  A1002 (-2.6A)
GDP  A1002 ( 3.8A)
None
 0.81A 5e26A-1xjeA:
undetectable
5e26B-1xjeA:
2.1		 5e26A-1xjeA:
21.27
5e26B-1xjeA:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E26_C_PAUC602_0
(PANTOTHENATE KINASE
2, MITOCHONDRIAL)		 1xje RIBONUCLEOTIDE
REDUCTASE,
B12-DEPENDENT
(Thermotoga
maritima) 		4 / 7 GLU A 324
GLY A 162
GLY A 164
ALA A 210
 GDP  A1002 (-2.6A)
GDP  A1002 ( 3.8A)
None
GDP  A1002 (-3.4A)
 0.84A 5e26C-1xjeA:
2.1
5e26D-1xjeA:
1.3		 5e26C-1xjeA:
21.27
5e26D-1xjeA:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E26_C_PAUC602_0
(PANTOTHENATE KINASE
2, MITOCHONDRIAL)		 5i67 PHOSPHOENOLPYRUVATE
CARBOXYKINASE [GTP]
(Mycobacterium
tuberculosis) 		4 / 7 GLY A 417
SER A 273
GLY A 274
ALA A 268
 None
None
GDP  A 701 (-3.2A)
None
 0.87A 5e26C-5i67A:
undetectable
5e26D-5i67A:
undetectable		 5e26C-5i67A:
22.24
5e26D-5i67A:
22.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E26_D_PAUD601_0
(PANTOTHENATE KINASE
2, MITOCHONDRIAL)		 5i67 PHOSPHOENOLPYRUVATE
CARBOXYKINASE [GTP]
(Mycobacterium
tuberculosis) 		4 / 8 ALA A 268
GLY A 417
SER A 273
GLY A 274
 None
None
None
GDP  A 701 (-3.2A)
 0.90A 5e26C-5i67A:
undetectable
5e26D-5i67A:
undetectable		 5e26C-5i67A:
22.24
5e26D-5i67A:
22.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EHG_A_SAMA301_0
(RNA-DIRECTED RNA
POLYMERASE NS5)		 1rpn GDP-MANNOSE
4,6-DEHYDRATASE
(Pseudomonas
aeruginosa) 		5 / 12 GLY A 212
ASP A 215
VAL A 214
ASP A 274
ILE A 273
 GDP  A1601 (-3.3A)
None
None
None
None
 0.90A 5ehgA-1rpnA:
4.4		 5ehgA-1rpnA:
22.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EHG_C_SAMC4001_0
(RNA-DIRECTED RNA
POLYMERASE NS5)		 4m8n PLEXINC1
INTRACELLULAR REGION
RAS-RELATED PROTEIN
RAP-1B
(Danio
rerio;
Homo
sapiens) 		5 / 12 GLY E  15
GLY E  60
GLY E  13
VAL A1004
ILE E  36
 GDP  E 201 (-3.6A)
AF3  E 202 (-3.3A)
GDP  E 201 ( 3.1A)
None
None
 0.97A 5ehgC-4m8nE:
undetectable		 5ehgC-4m8nE:
19.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EHG_C_SAMC4001_0
(RNA-DIRECTED RNA
POLYMERASE NS5)		 4xcq TUBZ
(Clostridium
phage
c-st) 		5 / 12 GLY A  57
GLY A 101
GLY A  59
THR A  95
ILE A  10
 None
GDP  A 401 (-3.3A)
None
GDP  A 401 (-3.0A)
None
 0.96A 5ehgC-4xcqA:
2.8		 5ehgC-4xcqA:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EQB_A_1YNA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 3j4s FTSZ/TUBULIN-RELATED
PROTEIN
(Bacillus
thuringiensis) 		5 / 12 GLY A 116
ILE A 166
GLY A 136
GLY A 142
PHE A 131
 None
None
GDP  A 900 (-3.6A)
None
None
 1.12A 5eqbA-3j4sA:
undetectable		 5eqbA-3j4sA:
22.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ESK_A_1YNA701_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 2qag SEPTIN-2
(Homo
sapiens) 		5 / 12 GLY A 241
PHE A 167
ILE A 171
THR A  98
THR A  52
 None
None
None
None
GDP  A 362 (-3.9A)
 1.19A 5eskA-2qagA:
undetectable		 5eskA-2qagA:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EWU_B_BEZB1401_0
(MAGNESIUM-CHELATASE
SUBUNIT CHLH,
CHLOROPLASTIC)		 3zid TUBULIN/FTSZ, GTPASE
(Methanothrix
thermoacetophila) 		4 / 6 GLY A 117
THR A 116
SER A 121
VAL A   9
 GDP  A 999 (-3.5A)
GDP  A 999 (-4.3A)
None
None
 1.13A 5ewuB-3zidA:
2.3		 5ewuB-3zidA:
23.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5F8Y_A_X6XA203_1
(GALNAC/GAL-SPECIFIC
LECTIN)		 2lkd TRANSLATION
INITIATION FACTOR
IF-2
(Geobacillus
stearothermophil
us) 		5 / 9 HIS A  19
GLY A  20
VAL A  85
ASP A  90
ASN A 115
 None
GDP  A 179 (-3.0A)
None
None
GDP  A 179 (-3.6A)
 1.50A 5f8yA-2lkdA:
undetectable		 5f8yA-2lkdA:
22.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FJ3_B_H4BB600_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 4oro POLYMERASE PB2
(Influenza
B
virus) 		4 / 7 PHE A 365
SER A 407
ARG A 334
TRP A 359
 None
None
GDP  A 501 (-4.1A)
GDP  A 501 (-3.3A)
 1.25A 5fj3A-4oroA:
undetectable
5fj3B-4oroA:
undetectable		 5fj3A-4oroA:
18.69
5fj3B-4oroA:
18.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FSA_B_X2NB590_2
(CYP51 VARIANT1)		 2yv5 YJEQ PROTEIN
(Aquifex
aeolicus) 		3 / 3 PRO A  92
LEU A  99
SER A 174
 None
None
GDP  A1001 ( 4.1A)
 0.85A 5fsaB-2yv5A:
undetectable		 5fsaB-2yv5A:
22.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5H4D_A_BBIA403_1
(NAD-DEPENDENT
PROTEIN DEACETYLASE
SIRTUIN-3,
MITOCHONDRIAL)		 5oed GTGE
RAS-RELATED PROTEIN
RAB-32
(Homo
sapiens;
Salmonella
enterica) 		4 / 6 PHE B  88
ARG B  87
GLU B  86
GLU A 198
 None
None
GDP  B 900 (-4.0A)
None
 1.21A 5h4dA-5oedB:
3.2		 5h4dA-5oedB:
14.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HFJ_C_SAMC301_0
(ADENINE SPECIFIC DNA
METHYLTRANSFERASE
(DPNA))		 6b9g ATLASTIN-1
(Homo
sapiens) 		5 / 12 ASP B 218
THR B 150
GLY B  74
THR B 147
SER B 179
 GDP  B 401 (-2.7A)
None
None
None
None
 1.29A 5hfjC-6b9gB:
undetectable		 5hfjC-6b9gB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HIE_A_P06A801_2
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 3d45 POLY(A)-SPECIFIC
RIBONUCLEASE PARN
(Mus
musculus) 		4 / 7 ILE A  34
GLY A  33
PHE A 293
PHE A  69
 GDP  A 652 ( 4.4A)
None
None
None
 1.14A 5hieA-3d45A:
undetectable		 5hieA-3d45A:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HNX_B_TA1B902_1
(TUBULIN BETA-2B
CHAIN)		 5cju ISOBUTYRYL-COA
MUTASE FUSED
(Cupriavidus
metallidurans) 		5 / 12 ASP A 360
SER A 435
THR A 226
ARG A 265
ARG A 361
 GDP  A1104 (-3.0A)
None
None
GDP  A1104 (-3.5A)
None
 1.37A 5hnxB-5cjuA:
0.4		 5hnxB-5cjuA:
16.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HNZ_B_TA1B902_1
(TUBULIN BETA-2B
CHAIN)		 4m8n PLEXINC1
INTRACELLULAR REGION
(Danio
rerio) 		5 / 12 VAL A1067
ASP A 988
HIS A 991
PHE A 972
ARG A 711
 None
None
None
None
GDP  E 201 ( 2.9A)
 1.34A 5hnzB-4m8nA:
undetectable		 5hnzB-4m8nA:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HRQ_G_IPHG101_0
(INSULIN A-CHAIN
INSULIN B-CHAIN)		 3jb9 PRE-MRNA-SPLICING
FACTOR CWF10
(Schizosaccharomy
ces
pombe) 		4 / 6 HIS B 220
LEU B 150
CYH B 911
HIS B 151
 None
None
None
GDP  B1000 ( 4.8A)
 1.41A 5hrqD-3jb9B:
undetectable
5hrqG-3jb9B:
undetectable
5hrqH-3jb9B:
undetectable		 5hrqD-3jb9B:
2.65
5hrqG-3jb9B:
3.57
5hrqH-3jb9B:
2.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HSW_A_ACTA501_0
(ORF 37)		 5yew MITOFUSIN-1,MITOFUSI
N-1 FUSION PROTEIN
(Homo
sapiens) 		4 / 5 SER B  90
SER B  89
SER B 103
SER B  85
 GDP  B 801 (-2.5A)
MG  B 804 ( 2.1A)
GDP  B 801 (-4.5A)
K  B 803 ( 2.9A)
 1.44A 5hswA-5yewB:
2.3		 5hswA-5yewB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IEN_A_VDYA201_1
(CDL2.2)		 2dby GTP-BINDING PROTEIN
(Thermus
thermophilus) 		5 / 12 PHE A 110
LEU A 215
THR A  16
ALA A 247
LEU A 249
 GDP  A 501 (-4.1A)
None
GDP  A 501 (-3.9A)
None
None
 1.30A 5ienA-2dbyA:
undetectable		 5ienA-2dbyA:
16.11
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5IGI_A_ZITA402_2
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E)		 5igp MACROLIDE
2'-PHOSPHOTRANSFERAS
E
(Escherichia
coli) 		6 / 6 PRO A 112
HIS A 205
GLU A 222
ALA A 233
LEU A 270
TYR A 277
 ERY  A 402 ( 4.1A)
GDP  A 401 (-4.4A)
ERY  A 402 ( 3.9A)
ERY  A 402 ( 3.9A)
None
ERY  A 402 ( 4.5A)
 0.00A 5igiA-5igpA:
47.5		 5igiA-5igpA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5IGJ_A_CTYA402_2
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E)		 5igp MACROLIDE
2'-PHOSPHOTRANSFERAS
E
(Escherichia
coli) 		5 / 5 PRO A 112
HIS A 205
LEU A 270
TYR A 277
PHE A 280
 ERY  A 402 ( 4.1A)
GDP  A 401 (-4.4A)
None
ERY  A 402 ( 4.5A)
ERY  A 402 ( 3.6A)
 0.18A 5igjA-5igpA:
48.1		 5igjA-5igpA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGP_A_ERYA402_0
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E)		 2vaw CELL DIVISION
PROTEIN FTSZ
(Pseudomonas
aeruginosa) 		5 / 12 ILE A 164
GLU A 149
ALA A 113
ALA A 114
GLY A 108
 None
None
None
None
GDP  A1317 (-3.4A)
 1.21A 5igpA-2vawA:
undetectable		 5igpA-2vawA:
22.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKM_A_SAMA311_0
(NS5 METHYL
TRANSFERASE)		 4xcq TUBZ
(Clostridium
phage
c-st) 		5 / 12 GLY A  57
GLY A 101
GLY A  59
THR A  95
ILE A  10
 None
GDP  A 401 (-3.3A)
None
GDP  A 401 (-3.0A)
None
 0.92A 5ikmA-4xcqA:
2.4		 5ikmA-4xcqA:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5J2T_C_VLBC503_2
(TUBULIN ALPHA-1B
CHAIN)		 3r4v PUTATIVE
UNCHARACTERIZED
PROTEIN
(Pseudomonas
phage
201phi2-1) 		5 / 12 ASN A 165
ILE A 168
ALA A 169
VAL A 118
GLY A 119
 GDP  A 400 (-2.9A)
None
None
GDP  A 400 (-4.6A)
None
 0.77A 5j2tC-3r4vA:
19.7		 5j2tC-3r4vA:
21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JW1_A_CELA602_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 3md0 ARGININE/ORNITHINE
TRANSPORT SYSTEM
ATPASE
(Mycobacterium
tuberculosis) 		6 / 12 VAL A 201
LEU A 221
ALA A 244
VAL A  69
GLY A  65
LEU A 187
 None
None
GDP  A 335 (-4.1A)
GDP  A 335 ( 4.6A)
None
None
 1.48A 5jw1A-3md0A:
undetectable		 5jw1A-3md0A:
18.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KB6_A_ADNA401_1
(ADENOSINE KINASE)		 1ofu CELL DIVISION
PROTEIN FTSZ
(Pseudomonas
aeruginosa) 		6 / 12 GLY A  20
ILE A  17
ALA A 113
GLY A 112
ALA A 114
ILE A 117
 GDP  A1318 (-3.5A)
None
None
None
None
None
 1.31A 5kb6A-1ofuA:
8.3		 5kb6A-1ofuA:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KB6_A_ADNA401_1
(ADENOSINE KINASE)		 2r6r CELL DIVISION
PROTEIN FTSZ
(Aquifex
aeolicus) 		6 / 12 GLY 1  16
ILE 1  13
ALA 1 109
GLY 1 108
ALA 1 110
ILE 1 113
 GDP  1 339 (-3.5A)
None
None
None
None
None
 1.32A 5kb6A-2r6r1:
8.1		 5kb6A-2r6r1:
23.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KB6_A_ADNA401_1
(ADENOSINE KINASE)		 2vaw CELL DIVISION
PROTEIN FTSZ
(Pseudomonas
aeruginosa) 		6 / 12 GLY A  20
ILE A  17
ALA A 113
GLY A 112
ALA A 114
ILE A 117
 GDP  A1317 (-3.4A)
None
None
None
None
None
 1.46A 5kb6A-2vawA:
8.1		 5kb6A-2vawA:
24.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KB6_B_ADNB401_1
(ADENOSINE KINASE)		 1ofu CELL DIVISION
PROTEIN FTSZ
(Pseudomonas
aeruginosa) 		6 / 12 GLY A  20
ILE A  17
ALA A 113
GLY A 112
ALA A 114
ILE A 117
 GDP  A1318 (-3.5A)
None
None
None
None
None
 1.32A 5kb6B-1ofuA:
7.7		 5kb6B-1ofuA:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KB6_B_ADNB401_1
(ADENOSINE KINASE)		 2r6r CELL DIVISION
PROTEIN FTSZ
(Aquifex
aeolicus) 		6 / 12 GLY 1  16
ILE 1  13
ALA 1 109
GLY 1 108
ALA 1 110
ILE 1 113
 GDP  1 339 (-3.5A)
None
None
None
None
None
 1.32A 5kb6B-2r6r1:
7.6		 5kb6B-2r6r1:
23.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KB6_B_ADNB401_1
(ADENOSINE KINASE)		 2vaw CELL DIVISION
PROTEIN FTSZ
(Pseudomonas
aeruginosa) 		6 / 12 GLY A  20
ILE A  17
ALA A 113
GLY A 112
ALA A 114
ILE A 117
 GDP  A1317 (-3.4A)
None
None
None
None
None
 1.46A 5kb6B-2vawA:
7.4		 5kb6B-2vawA:
24.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KMF_A_6U9A1301_1
(ION TRANSPORT
PROTEIN)		 3zy3 PUTATIVE GDP-FUCOSE
PROTEIN
O-FUCOSYLTRANSFERASE
1
(Caenorhabditis
elegans) 		4 / 6 THR A 356
GLY A  42
PHE A  41
ILE A  68
 GDP  A1384 (-2.9A)
GDP  A1384 (-3.1A)
None
None
 0.95A 5kmfA-3zy3A:
undetectable
5kmfC-3zy3A:
undetectable		 5kmfA-3zy3A:
20.77
5kmfC-3zy3A:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KOC_B_SAMB401_0
(PAVINE
N-METHYLTRANSFERASE)		 1moz ADP-RIBOSYLATION
FACTOR-LIKE PROTEIN
1
(Saccharomyces
cerevisiae) 		5 / 12 SER A  95
GLY A  30
SER A 159
THR A  33
VAL A  93
 None
GDP  A 184 (-2.8A)
None
GDP  A 184 (-3.9A)
None
 1.15A 5kocB-1mozA:
undetectable		 5kocB-1mozA:
18.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KPC_A_SAMA401_1
(PAVINE
N-METHYLTRANSFERASE)		 4oro POLYMERASE PB2
(Influenza
B
virus) 		4 / 5 PHE A 406
SER A 407
GLN A 437
ASP A 395
 GDP  A 501 (-4.2A)
None
None
None
 1.42A 5kpcA-4oroA:
undetectable		 5kpcA-4oroA:
18.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KPR_A_PAUA404_0
(PANTOTHENATE KINASE
3)		 3rwo GTP-BINDING PROTEIN
YPT32/YPT11
(Saccharomyces
cerevisiae) 		4 / 5 GLU B  73
GLY B  20
SER B  22
GLY B  23
 None
None
None
GDP  B4032 (-3.4A)
 0.96A 5kprA-3rwoB:
undetectable		 5kprA-3rwoB:
19.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KQR_A_SAMA301_0
(METHYLTRANSFERASE)		 4xcq TUBZ
(Clostridium
phage
c-st) 		5 / 12 GLY A  57
GLY A 101
GLY A  59
THR A  95
ILE A  10
 None
GDP  A 401 (-3.3A)
None
GDP  A 401 (-3.0A)
None
 0.92A 5kqrA-4xcqA:
2.8		 5kqrA-4xcqA:
22.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KQS_A_SAMA307_0
(GENOME POLYPROTEIN)		 4xcq TUBZ
(Clostridium
phage
c-st) 		5 / 12 GLY A  57
GLY A 101
GLY A  59
THR A  95
ILE A  10
 None
GDP  A 401 (-3.3A)
None
GDP  A 401 (-3.0A)
None
 0.92A 5kqsA-4xcqA:
2.8		 5kqsA-4xcqA:
22.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L0Z_B_SAMB304_0
(PROBABLE RNA
METHYLTRANSFERASE,
TRMH FAMILY)		 3zid TUBULIN/FTSZ, GTPASE
(Methanothrix
thermoacetophila) 		5 / 10 LEU A   7
GLY A  10
GLY A  13
ILE A  93
LEU A  67
 None
GDP  A 999 (-3.5A)
None
None
None
 1.04A 5l0zB-3zidA:
undetectable		 5l0zB-3zidA:
23.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L2T_A_6ZZA900_2
(CYCLIN-DEPENDENT
KINASE 6)		 2rhd SMALL GTP BINDING
PROTEIN RAB1A
(Cryptosporidium
parvum) 		3 / 3 LYS A  22
GLN A 102
ASN A  99
 GDP  A3800 (-2.6A)
None
MG  A1002 ( 4.7A)
 0.77A 5l2tA-2rhdA:
undetectable		 5l2tA-2rhdA:
18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L2T_A_6ZZA900_2
(CYCLIN-DEPENDENT
KINASE 6)		 3cph RAS-RELATED PROTEIN
SEC4
(Saccharomyces
cerevisiae) 		3 / 3 LYS A  33
GLN A 113
ASN A 110
 GDP  A 302 (-2.6A)
None
None
 0.78A 5l2tA-3cphA:
undetectable		 5l2tA-3cphA:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L2T_A_6ZZA900_2
(CYCLIN-DEPENDENT
KINASE 6)		 4jvs RAS-RELATED PROTEIN
RAB-1A
(Homo
sapiens) 		3 / 3 LYS B  24
GLN B 104
ASN B 101
 GDP  B 400 ( 2.6A)
None
None
 0.68A 5l2tA-4jvsB:
undetectable		 5l2tA-4jvsB:
19.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L2T_A_6ZZA900_2
(CYCLIN-DEPENDENT
KINASE 6)		 4z8y RAS-RELATED PROTEIN
SEC4
(Saccharomyces
cerevisiae) 		3 / 3 LYS A  33
GLN A 113
ASN A 110
 GDP  A 201 (-2.7A)
None
None
 0.79A 5l2tA-4z8yA:
undetectable		 5l2tA-4z8yA:
18.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L8D_B_ACTB601_0
(NICKEL-BINDING
PERIPLASMIC PROTEIN)		 4b46 CELL DIVISION
PROTEIN FTSZ
(Haloferax
volcanii) 		3 / 3 THR A 147
PRO A 138
ASP A 168
 None
GDP  A1368 (-4.2A)
None
 0.59A 5l8dB-4b46A:
undetectable		 5l8dB-4b46A:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LF7_N_6V8N305_0
(PROTEASOME SUBUNIT
BETA TYPE-6
PROTEASOME SUBUNIT
BETA TYPE-7)		 2ng1 SIGNAL SEQUENCE
RECOGNITION PROTEIN
FFH
(Thermus
aquaticus) 		5 / 12 THR A 188
THR A 112
THR A 113
ALA A 116
GLY A 105
 None
GDP  A 900 (-4.2A)
GDP  A 900 (-3.6A)
EDO  A 973 ( 4.6A)
EDO  A 971 (-4.8A)
 1.19A 5lf7H-2ng1A:
2.8
5lf7N-2ng1A:
undetectable		 5lf7H-2ng1A:
19.47
5lf7N-2ng1A:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LJC_A_RTLA201_1
(RETINOL-BINDING
PROTEIN 1)		 5tc3 INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE
(Eremothecium
gossypii) 		4 / 7 LEU A 203
ILE A 164
THR A 165
MET A 223
 None
None
ATP  A 601 (-2.7A)
GDP  A 602 (-4.7A)
 1.43A 5ljcA-5tc3A:
undetectable		 5ljcA-5tc3A:
13.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M24_A_9CRA501_1
(RETINOIC ACID
RECEPTOR GAMMA)		 2r6r CELL DIVISION
PROTEIN FTSZ
(Aquifex
aeolicus) 		6 / 12 PHE 1 132
ALA 1 178
ILE 1 165
SER 1 169
GLY 1  18
ILE 1 175
 None
None
None
None
GDP  1 339 (-3.4A)
None
 1.33A 5m24A-2r6r1:
undetectable		 5m24A-2r6r1:
24.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M50_B_TA1B502_1
(TUBULIN BETA-2B
CHAIN)		 3t34 DYNAMIN-RELATED
PROTEIN 1A, LINKER,
DYNAMIN-RELATED
PROTEIN 1A
(Arabidopsis
thaliana) 		5 / 12 ASP A 142
GLU A  52
SER A  53
ARG A 243
GLY A  63
 MG  A1002 ( 3.9A)
None
None
None
GDP  A1000 ( 3.5A)
 1.23A 5m50B-3t34A:
3.0		 5m50B-3t34A:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M50_E_TA1E502_1
(TUBULIN BETA-2B
CHAIN)		 3t34 DYNAMIN-RELATED
PROTEIN 1A, LINKER,
DYNAMIN-RELATED
PROTEIN 1A
(Arabidopsis
thaliana) 		5 / 12 ASP A 142
GLU A  52
SER A  53
ARG A 243
GLY A  63
 MG  A1002 ( 3.9A)
None
None
None
GDP  A1000 ( 3.5A)
 1.24A 5m50E-3t34A:
3.9		 5m50E-3t34A:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M54_E_TA1E502_1
(TUBULIN BETA-2B
CHAIN)		 5w76 ANCESTRAL ELOGATION
FACTOR N153
(synthetic
construct) 		5 / 12 ASP A 139
ALA A 188
THR A  33
GLY A  24
LEU A  28
 GDP  A 404 (-2.3A)
None
None
GDP  A 404 (-3.1A)
None
 1.18A 5m54E-5w76A:
5.1		 5m54E-5w76A:
9.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M5B_A_SAMA1001_0
(NS5
METHYLTRANSFERASE)		 4xcq TUBZ
(Clostridium
phage
c-st) 		5 / 12 GLY A  57
GLY A 101
GLY A  59
THR A  95
ILE A  10
 None
GDP  A 401 (-3.3A)
None
GDP  A 401 (-3.0A)
None
 0.92A 5m5bA-4xcqA:
3.0		 5m5bA-4xcqA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MFX_A_ACTA701_0
(GENOME POLYPROTEIN)		 5cju ISOBUTYRYL-COA
MUTASE FUSED
(Cupriavidus
metallidurans) 		4 / 5 ARG A 232
THR A 394
ALA A 396
ASP A 401
 None
None
GDP  A1104 (-3.8A)
None
 1.37A 5mfxA-5cjuA:
2.1		 5mfxA-5cjuA:
17.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MSD_A_BEZA1202_0
(CARBOXYLIC ACID
REDUCTASE)		 5kx6 GALACTOSIDE
2-ALPHA-L-FUCOSYLTRA
NSFERASE
(Arabidopsis
thaliana) 		4 / 5 HIS A 523
ILE A 551
PHE A 368
ALA A 480
 None
None
GDP  A 601 (-4.9A)
None
 1.19A 5msdA-5kx6A:
undetectable		 5msdA-5kx6A:
18.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MVS_A_ADNA401_1
(HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-79
SPECIFIC)		 1xje RIBONUCLEOTIDE
REDUCTASE,
B12-DEPENDENT
(Thermotoga
maritima) 		4 / 7 GLY A 323
GLU A 324
ALA A 489
ASN A 242
 None
GDP  A1002 (-2.6A)
GDP  A1002 (-3.4A)
None
 0.87A 5mvsA-1xjeA:
undetectable		 5mvsA-1xjeA:
20.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MVS_A_ADNA401_1
(HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-79
SPECIFIC)		 2qag SEPTIN-2
(Homo
sapiens) 		4 / 7 GLY A 241
LYS A 183
ALA A 182
ASN A  55
 None
GDP  A 362 (-3.9A)
None
None
 0.88A 5mvsA-2qagA:
undetectable		 5mvsA-2qagA:
20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MVS_A_ADNA401_1
(HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-79
SPECIFIC)		 2qnr SEPTIN-2
(Homo
sapiens) 		4 / 7 GLY A 241
LYS A 183
ALA A 182
ASN A  55
 GDP  A1401 (-3.9A)
GDP  A1401 (-3.2A)
None
None
 0.85A 5mvsA-2qnrA:
undetectable		 5mvsA-2qnrA:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MVS_B_ADNB401_1
(HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-79
SPECIFIC)		 1xje RIBONUCLEOTIDE
REDUCTASE,
B12-DEPENDENT
(Thermotoga
maritima) 		4 / 8 GLY A 323
GLU A 324
ALA A 489
ASN A 242
 None
GDP  A1002 (-2.6A)
GDP  A1002 (-3.4A)
None
 0.85A 5mvsB-1xjeA:
undetectable		 5mvsB-1xjeA:
20.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MWU_B_ACTB601_0
(NICKEL-BINDING
PERIPLASMIC PROTEIN)		 4b46 CELL DIVISION
PROTEIN FTSZ
(Haloferax
volcanii) 		3 / 3 THR A 147
PRO A 138
ASP A 168
 None
GDP  A1368 (-4.2A)
None
 0.59A 5mwuB-4b46A:
undetectable		 5mwuB-4b46A:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MZR_E_PFLE409_1
(PROTON-GATED ION
CHANNEL)		 3r4v PUTATIVE
UNCHARACTERIZED
PROTEIN
(Pseudomonas
phage
201phi2-1) 		4 / 8 TYR A 161
ILE A 164
VAL A 118
THR A  13
 GDP  A 400 (-3.7A)
GDP  A 400 (-3.7A)
GDP  A 400 (-4.6A)
GDP  A 400 (-3.5A)
 0.83A 5mzrE-3r4vA:
undetectable		 5mzrE-3r4vA:
16.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0O_B_SAMB501_0
(PEPTIDE
N-METHYLTRANSFERASE)		 2e87 HYPOTHETICAL PROTEIN
PH1320
(Pyrococcus
horikoshii) 		5 / 12 ILE A 323
GLY A 322
SER A 316
ALA A 317
ALA A 186
 None
None
GDP  A 400 (-3.1A)
GDP  A 400 (-3.7A)
None
 1.05A 5n0oB-2e87A:
2.2		 5n0oB-2e87A:
22.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0S_B_SAMB501_1
(PEPTIDE
N-METHYLTRANSFERASE)		 4c7o SIGNAL RECOGNITION
PARTICLE PROTEIN
(Escherichia
coli) 		4 / 4 GLY A 193
ALA A 111
MET A 105
THR A 248
 ALF  A1001 (-3.1A)
GDP  A1003 (-4.1A)
None
GDP  A1003 ( 4.4A)
 1.49A 5n0sB-4c7oA:
5.6		 5n0sB-4c7oA:
24.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N5D_A_SAMA306_1
(METHYLTRANSFERASE)		 3kxi GTP-BINDING PROTEIN
(HFLX)
(Sulfolobus
solfataricus) 		4 / 7 LEU A 274
SER A 320
ILE A 331
ASN A 300
 None
None
None
GDP  A 500 (-3.0A)
 0.98A 5n5dA-3kxiA:
2.6		 5n5dA-3kxiA:
18.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5O96_C_SAMC501_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE E)		 2ng1 SIGNAL SEQUENCE
RECOGNITION PROTEIN
FFH
(Thermus
aquaticus) 		4 / 7 LEU A 131
LEU A 103
THR A 112
ALA A 115
 None
None
GDP  A 900 (-4.2A)
None
 0.71A 5o96C-2ng1A:
2.3		 5o96C-2ng1A:
22.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5O96_C_SAMC501_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE E)		 2www METHYLMALONIC
ACIDURIA TYPE A
PROTEIN,
MITOCHONDRIAL
(Homo
sapiens) 		5 / 7 GLY A 155
GLY A 153
SER A 291
THR A 158
ALA A 329
 GDP  A 600 (-3.4A)
GDP  A 600 (-3.5A)
None
GDP  A 600 (-3.3A)
GDP  A 600 (-4.0A)
 1.43A 5o96C-2wwwA:
undetectable		 5o96C-2wwwA:
22.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5O96_H_SAMH501_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE E)		 2ng1 SIGNAL SEQUENCE
RECOGNITION PROTEIN
FFH
(Thermus
aquaticus) 		5 / 10 LEU A 131
LEU A 185
LEU A 103
THR A 112
ALA A 115
 None
None
None
GDP  A 900 (-4.2A)
None
 0.89A 5o96G-2ng1A:
undetectable
5o96H-2ng1A:
undetectable		 5o96G-2ng1A:
22.88
5o96H-2ng1A:
22.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OV9_A_CVIA608_0
(ACETYLCHOLINESTERASE)		 1ukv GTP-BINDING PROTEIN
YPT1
(Saccharomyces
cerevisiae) 		4 / 7 ASP Y  63
LEU Y  13
THR Y  64
VAL Y  19
 MG  Y1208 ( 4.0A)
None
None
GDP  Y1207 (-4.1A)
 1.08A 5ov9A-1ukvY:
undetectable		 5ov9A-1ukvY:
16.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OV9_A_CVIA608_0
(ACETYLCHOLINESTERASE)		 5xc3 PROBABLE RAB-RELATED
GTPASE
(Acanthamoeba
polyphaga
mimivirus) 		4 / 7 ASP A  61
LEU A  10
THR A  62
VAL A  16
 MG  A1201 ( 4.0A)
None
None
GDP  A1200 (-4.0A)
 1.12A 5ov9A-5xc3A:
2.4		 5ov9A-5xc3A:
15.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OV9_B_CVIB602_0
(ACETYLCHOLINESTERASE)		 3cpj GTP-BINDING PROTEIN
YPT31/YPT8
(Saccharomyces
cerevisiae) 		4 / 8 ASP B  68
LEU B  18
THR B  69
VAL B  24
 MG  B1208 ( 4.2A)
None
None
GDP  B1207 ( 4.3A)
 1.27A 5ov9B-3cpjB:
undetectable		 5ov9B-3cpjB:
17.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OV9_B_CVIB602_0
(ACETYLCHOLINESTERASE)		 4djt GTP-BINDING NUCLEAR
PROTEIN GSP1
(Encephalitozoon
cuniculi) 		4 / 8 ASP A  63
LEU A  12
THR A  64
VAL A  18
 MG  A 302 ( 4.0A)
None
None
GDP  A 301 (-3.9A)
 1.30A 5ov9B-4djtA:
undetectable		 5ov9B-4djtA:
19.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OV9_B_CVIB602_0
(ACETYLCHOLINESTERASE)		 5ub8 LIKELY RAB FAMILY
GTP-BINDING PROTEIN
(Candida
albicans) 		4 / 8 ASP A  70
LEU A  20
THR A  71
VAL A  26
 ZN  A 302 ( 3.9A)
None
None
GDP  A 301 (-4.1A)
 1.22A 5ov9B-5ub8A:
undetectable		 5ov9B-5ub8A:
17.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5SXQ_B_NIZB808_1
(CATALASE-PEROXIDASE)		 5h7k ELONGATION FACTOR 2
(Pyrococcus
horikoshii) 		4 / 8 VAL A 118
GLY A  36
LEU A  40
THR A  38
 None
GDP  A 501 (-3.4A)
None
GDP  A 501 (-3.8A)
 1.02A 5sxqB-5h7kA:
undetectable		 5sxqB-5h7kA:
9.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5SYJ_A_NIZA809_1
(CATALASE-PEROXIDASE)		 5h7k ELONGATION FACTOR 2
(Pyrococcus
horikoshii) 		4 / 8 VAL A 118
GLY A  36
LEU A  40
THR A  38
 None
GDP  A 501 (-3.4A)
None
GDP  A 501 (-3.8A)
 1.02A 5syjA-5h7kA:
undetectable		 5syjA-5h7kA:
9.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5T7B_A_IPHA902_0
(PROTEIN ARGONAUTE-2)		 1p9b ADENYLOSUCCINATE
SYNTHETASE
(Plasmodium
falciparum) 		4 / 7 LEU A 343
LYS A 339
LEU A 298
GLU A 304
 None
GDP  A1603 (-2.9A)
None
None
 1.07A 5t7bA-1p9bA:
0.0		 5t7bA-1p9bA:
18.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TE8_C_08JC602_1
(CYTOCHROME P450 3A4)		 2dyk GTP-BINDING PROTEIN
(Thermus
thermophilus) 		4 / 7 SER A 143
LEU A 149
ILE A 156
LEU A 153
 GDP  A 501 (-4.3A)
None
None
None
 0.89A 5te8C-2dykA:
undetectable		 5te8C-2dykA:
14.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TWJ_C_SAMC201_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE H)		 2yv5 YJEQ PROTEIN
(Aquifex
aeolicus) 		5 / 12 LEU A 170
ILE A 169
GLY A 225
SER A 179
LEU A 182
 None
None
None
GDP  A1001 (-4.5A)
None
 1.08A 5twjC-2yv5A:
undetectable		 5twjC-2yv5A:
19.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5U63_B_ACTB405_0
(THIOREDOXIN
REDUCTASE)		 3jb9 PRE-MRNA-SPLICING
FACTOR CWF10
(Schizosaccharomy
ces
pombe) 		3 / 3 GLY B 219
LEU B 150
HIS B 220
 GDP  B1000 ( 4.7A)
None
None
 0.70A 5u63B-3jb9B:
undetectable		 5u63B-3jb9B:
16.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UHG_C_RFPC1201_1
(DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA)		 5vys GDP-MANNOSE
4,6-DEHYDRATASE /
GDP-4-AMINO-4,6-DIDE
OXY-D-MANNOSE
FORMYLTRANSFERASE
(Brucella
melitensis) 		5 / 12 LEU A 164
ARG A  45
PRO A  17
ILE A 169
HIS A 136
 None
GDP  A 303 (-2.6A)
None
None
1YJ  A 301 (-4.5A)
 1.39A 5uhgC-5vysA:
undetectable		 5uhgC-5vysA:
13.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UO7_A_H4BA802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 4oro POLYMERASE PB2
(Influenza
B
virus) 		4 / 8 SER A 407
ARG A 334
TRP A 359
PHE A 365
 None
GDP  A 501 (-4.1A)
GDP  A 501 (-3.3A)
None
 1.25A 5uo7A-4oroA:
undetectable
5uo7B-4oroA:
undetectable		 5uo7A-4oroA:
18.51
5uo7B-4oroA:
18.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UO8_A_H4BA502_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 4oro POLYMERASE PB2
(Influenza
B
virus) 		4 / 6 SER A 407
ARG A 334
TRP A 359
PHE A 365
 None
GDP  A 501 (-4.1A)
GDP  A 501 (-3.3A)
None
 1.22A 5uo8A-4oroA:
undetectable
5uo8B-4oroA:
undetectable		 5uo8A-4oroA:
19.89
5uo8B-4oroA:
19.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UUN_A_ACTA310_0
(GLUTATHIONE
S-TRANSFERASE-LIKE
PROTEIN)		 1p9b ADENYLOSUCCINATE
SYNTHETASE
(Plasmodium
falciparum) 		3 / 3 GLU A 300
HIS A 303
ARG A 313
 None
None
GDP  A1603 ( 3.4A)
 0.97A 5uunA-1p9bA:
0.0		 5uunA-1p9bA:
22.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VIM_B_SAMB301_0
(METHYLTRANSFERASE)		 4m8n PLEXINC1
INTRACELLULAR REGION
RAS-RELATED PROTEIN
RAP-1B
(Danio
rerio;
Homo
sapiens) 		5 / 12 GLY E  15
GLY E  60
GLY E  13
VAL A1004
ILE E  36
 GDP  E 201 (-3.6A)
AF3  E 202 (-3.3A)
GDP  E 201 ( 3.1A)
None
None
 0.95A 5vimB-4m8nE:
undetectable		 5vimB-4m8nE:
20.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VLM_C_CVIC301_1
(REGULATORY PROTEIN
TETR)		 3p27 ELONGATION FACTOR 1
ALPHA-LIKE PROTEIN
(Saccharomyces
cerevisiae) 		4 / 7 GLY A 353
ILE A 362
ASP A 190
TYR A 189
 GDP  A 663 (-3.6A)
None
None
None
 0.97A 5vlmC-3p27A:
undetectable		 5vlmC-3p27A:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VLM_D_CVID301_0
(REGULATORY PROTEIN
TETR)		 1z2a RAS-RELATED PROTEIN
RAB-23
(Mus
musculus) 		5 / 12 ALA A  99
LEU A 118
TYR A  78
VAL A  20
THR A  91
 None
None
None
GDP  A 201 (-4.0A)
None
 1.40A 5vlmD-1z2aA:
undetectable		 5vlmD-1z2aA:
25.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VLM_H_CVIH301_1
(REGULATORY PROTEIN
TETR)		 4n9w GDP-MANNOSE-DEPENDEN
T
ALPHA-(1-2)-PHOSPHAT
IDYLINOSITOL
MANNOSYLTRANSFERASE
(Mycolicibacteriu
m
smegmatis) 		4 / 8 GLN A 250
GLY A 195
ILE A 225
GLN A 237
 None
GDP  A 401 ( 4.7A)
None
None
 1.02A 5vlmH-4n9wA:
undetectable		 5vlmH-4n9wA:
19.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VNC_C_GCSC801_1
(GLYCOGEN [STARCH]
SYNTHASE ISOFORM 2)		 4n9w GDP-MANNOSE-DEPENDEN
T
ALPHA-(1-2)-PHOSPHAT
IDYLINOSITOL
MANNOSYLTRANSFERASE
(Mycolicibacteriu
m
smegmatis) 		5 / 10 GLY A  16
HIS A 118
VAL A 147
ASN A 168
GLY A 277
 GDP  A 401 (-3.7A)
None
None
None
None
 0.63A 5vncC-4n9wA:
20.8		 5vncC-4n9wA:
13.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VOO_A_C2FA3001_0
(5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE)		 5w3j TUBULIN BETA CHAIN
(Saccharomyces
cerevisiae) 		5 / 12 GLU B 108
GLY B  98
VAL B 116
GLY B  93
SER B  95
 None
GDP  B 501 (-4.4A)
None
None
None
 1.17A 5vooA-5w3jB:
2.2		 5vooA-5w3jB:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VOO_B_C2FB702_0
(5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE)		 5w3j TUBULIN BETA CHAIN
(Saccharomyces
cerevisiae) 		5 / 12 GLU B 108
GLY B  98
VAL B 116
GLY B  93
SER B  95
 None
GDP  B 501 (-4.4A)
None
None
None
 1.16A 5vooB-5w3jB:
2.3		 5vooB-5w3jB:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VOO_C_C2FC702_0
(5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE)		 5w3j TUBULIN BETA CHAIN
(Saccharomyces
cerevisiae) 		5 / 12 GLU B 108
GLY B  98
VAL B 116
GLY B  93
SER B  95
 None
GDP  B 501 (-4.4A)
None
None
None
 1.15A 5vooC-5w3jB:
2.3		 5vooC-5w3jB:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VOO_D_C2FD3001_0
(5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE)		 5w3j TUBULIN BETA CHAIN
(Saccharomyces
cerevisiae) 		5 / 12 GLU B 108
GLY B  98
VAL B 116
GLY B  93
SER B  95
 None
GDP  B 501 (-4.4A)
None
None
None
 1.18A 5vooD-5w3jB:
undetectable		 5vooD-5w3jB:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VOO_E_C2FE3001_0
(5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE)		 3zf8 MANNAN POLYMERASE
COMPLEXES SUBUNIT
MNN9
(Saccharomyces
cerevisiae) 		5 / 12 GLU A 364
VAL A 379
LEU A 333
GLY A 337
ARG A 209
 None
None
None
None
GDP  A1395 (-3.6A)
 1.20A 5vooE-3zf8A:
undetectable		 5vooE-3zf8A:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VOO_E_C2FE3001_0
(5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE)		 5w3j TUBULIN BETA CHAIN
(Saccharomyces
cerevisiae) 		5 / 12 GLU B 108
GLY B  98
VAL B 116
GLY B  93
SER B  95
 None
GDP  B 501 (-4.4A)
None
None
None
 1.14A 5vooE-5w3jB:
undetectable		 5vooE-5w3jB:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VOO_F_C2FF3001_0
(5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE)		 5w3j TUBULIN BETA CHAIN
(Saccharomyces
cerevisiae) 		5 / 12 GLU B 108
GLY B  98
VAL B 116
GLY B  93
SER B  95
 None
GDP  B 501 (-4.4A)
None
None
None
 1.19A 5vooF-5w3jB:
2.1		 5vooF-5w3jB:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VOP_B_C2FB3001_0
(5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE)		 3zf8 MANNAN POLYMERASE
COMPLEXES SUBUNIT
MNN9
(Saccharomyces
cerevisiae) 		5 / 12 GLU A 364
VAL A 379
LEU A 333
GLY A 337
ARG A 209
 None
None
None
None
GDP  A1395 (-3.6A)
 1.18A 5vopB-3zf8A:
undetectable		 5vopB-3zf8A:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VOP_B_C2FB3001_0
(5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE)		 5w3j TUBULIN BETA CHAIN
(Saccharomyces
cerevisiae) 		5 / 12 GLU B 108
GLY B  98
VAL B 116
GLY B  93
SER B  95
 None
GDP  B 501 (-4.4A)
None
None
None
 1.17A 5vopB-5w3jB:
undetectable		 5vopB-5w3jB:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VW4_A_NCAA403_0
(FERREDOXIN--NADP
REDUCTASE)		 5cju ISOBUTYRYL-COA
MUTASE FUSED
(Cupriavidus
metallidurans) 		5 / 9 THR A 217
GLY A 218
ALA A 220
GLY A 313
GLU A 310
 None
GDP  A1104 ( 4.5A)
GDP  A1104 (-4.8A)
None
MG  A1105 (-3.2A)
 1.06A 5vw4A-5cjuA:
undetectable		 5vw4A-5cjuA:
15.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VW9_A_NCAA403_0
(FERREDOXIN--NADP
REDUCTASE)		 2r6r CELL DIVISION
PROTEIN FTSZ
(Aquifex
aeolicus) 		4 / 8 THR 1 105
GLY 1 106
ALA 1 109
SER 1  20
 GDP  1 339 (-4.3A)
GDP  1 339 (-3.5A)
None
None
 0.56A 5vw9A-2r6r1:
3.1		 5vw9A-2r6r1:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WEA_A_IPHA901_0
(PROTEIN ARGONAUTE-2)		 1cg4 PROTEIN
(ADENYLOSUCCINATE
SYNTHETASE)
(Escherichia
coli) 		4 / 5 LEU A 335
LYS A 331
LEU A 290
GLU A 296
 None
GDP  A 432 (-3.0A)
None
None
 1.27A 5weaA-1cg4A:
1.7		 5weaA-1cg4A:
19.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WEA_A_IPHA901_0
(PROTEIN ARGONAUTE-2)		 1p9b ADENYLOSUCCINATE
SYNTHETASE
(Plasmodium
falciparum) 		4 / 5 LEU A 343
LYS A 339
LEU A 298
GLU A 304
 None
GDP  A1603 (-2.9A)
None
None
 1.15A 5weaA-1p9bA:
undetectable		 5weaA-1p9bA:
19.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WEA_A_IPHA901_0
(PROTEIN ARGONAUTE-2)		 2v40 ADENYLOSUCCINATE
SYNTHETASE ISOZYME 2
(Homo
sapiens) 		4 / 5 LEU A 366
LYS A 362
LEU A 321
GLU A 327
 None
GDP  A1457 (-3.0A)
None
None
 1.31A 5weaA-2v40A:
undetectable		 5weaA-2v40A:
20.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WZ1_A_SAMA601_0
(NS5
METHYLTRANSFERASE)		 1r5n EUKARYOTIC PEPTIDE
CHAIN RELEASE FACTOR
GTP-BINDING SUBUNIT
(Schizosaccharomy
ces
pombe) 		5 / 12 GLY A 250
GLY A 256
ASP A 266
VAL A 265
ILE A 273
 GDP  A 663 (-2.9A)
None
None
None
None
 0.91A 5wz1A-1r5nA:
undetectable		 5wz1A-1r5nA:
19.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WZ1_A_SAMA601_0
(NS5
METHYLTRANSFERASE)		 1rpn GDP-MANNOSE
4,6-DEHYDRATASE
(Pseudomonas
aeruginosa) 		5 / 12 GLY A 212
ASP A 215
VAL A 214
ASP A 274
ILE A 273
 GDP  A1601 (-3.3A)
None
None
None
None
 0.91A 5wz1A-1rpnA:
4.7		 5wz1A-1rpnA:
24.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WZ1_A_SAMA601_0
(NS5
METHYLTRANSFERASE)		 4xcq TUBZ
(Clostridium
phage
c-st) 		5 / 12 GLY A  57
GLY A 101
GLY A  59
THR A  95
ILE A  10
 None
GDP  A 401 (-3.3A)
None
GDP  A 401 (-3.0A)
None
 0.90A 5wz1A-4xcqA:
2.6		 5wz1A-4xcqA:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WZ1_B_SAMB601_0
(NS5
METHYLTRANSFERASE)		 4xcq TUBZ
(Clostridium
phage
c-st) 		5 / 12 GLY A  57
GLY A 101
GLY A  59
THR A  95
ILE A  10
 None
GDP  A 401 (-3.3A)
None
GDP  A 401 (-3.0A)
None
 0.91A 5wz1B-4xcqA:
2.7		 5wz1B-4xcqA:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WZ1_C_SAMC601_0
(NS5
METHYLTRANSFERASE)		 1r5n EUKARYOTIC PEPTIDE
CHAIN RELEASE FACTOR
GTP-BINDING SUBUNIT
(Schizosaccharomy
ces
pombe) 		5 / 12 GLY A 250
GLY A 256
ASP A 266
VAL A 265
ILE A 273
 GDP  A 663 (-2.9A)
None
None
None
None
 0.93A 5wz1C-1r5nA:
undetectable		 5wz1C-1r5nA:
19.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WZ1_C_SAMC601_0
(NS5
METHYLTRANSFERASE)		 1rpn GDP-MANNOSE
4,6-DEHYDRATASE
(Pseudomonas
aeruginosa) 		5 / 12 GLY A 212
ASP A 215
VAL A 214
ASP A 274
ILE A 273
 GDP  A1601 (-3.3A)
None
None
None
None
 0.96A 5wz1C-1rpnA:
4.4		 5wz1C-1rpnA:
24.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WZ1_C_SAMC601_0
(NS5
METHYLTRANSFERASE)		 4xcq TUBZ
(Clostridium
phage
c-st) 		5 / 12 GLY A  57
GLY A 101
GLY A  59
THR A  95
ILE A  10
 None
GDP  A 401 (-3.3A)
None
GDP  A 401 (-3.0A)
None
 0.90A 5wz1C-4xcqA:
2.6		 5wz1C-4xcqA:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WZ1_D_SAMD601_0
(NS5
METHYLTRANSFERASE)		 1rpn GDP-MANNOSE
4,6-DEHYDRATASE
(Pseudomonas
aeruginosa) 		5 / 12 GLY A 212
ASP A 215
VAL A 214
ASP A 274
ILE A 273
 GDP  A1601 (-3.3A)
None
None
None
None
 0.91A 5wz1D-1rpnA:
4.4		 5wz1D-1rpnA:
24.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WZ1_D_SAMD601_0
(NS5
METHYLTRANSFERASE)		 4xcq TUBZ
(Clostridium
phage
c-st) 		5 / 12 GLY A  57
GLY A 101
GLY A  59
THR A  95
ILE A  10
 None
GDP  A 401 (-3.3A)
None
GDP  A 401 (-3.0A)
None
 0.92A 5wz1D-4xcqA:
3.2		 5wz1D-4xcqA:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WZ1_E_SAME601_0
(NS5
METHYLTRANSFERASE)		 1r5n EUKARYOTIC PEPTIDE
CHAIN RELEASE FACTOR
GTP-BINDING SUBUNIT
(Schizosaccharomy
ces
pombe) 		5 / 12 GLY A 250
GLY A 256
ASP A 266
VAL A 265
ILE A 273
 GDP  A 663 (-2.9A)
None
None
None
None
 0.93A 5wz1E-1r5nA:
undetectable		 5wz1E-1r5nA:
19.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WZ1_E_SAME601_0
(NS5
METHYLTRANSFERASE)		 4xcq TUBZ
(Clostridium
phage
c-st) 		5 / 12 GLY A  57
GLY A 101
GLY A  59
THR A  95
ILE A  10
 None
GDP  A 401 (-3.3A)
None
GDP  A 401 (-3.0A)
None
 0.88A 5wz1E-4xcqA:
3.4		 5wz1E-4xcqA:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WZ1_F_SAMF601_0
(NS5
METHYLTRANSFERASE)		 1rpn GDP-MANNOSE
4,6-DEHYDRATASE
(Pseudomonas
aeruginosa) 		5 / 12 GLY A 212
ASP A 215
VAL A 214
ASP A 274
ILE A 273
 GDP  A1601 (-3.3A)
None
None
None
None
 0.90A 5wz1F-1rpnA:
4.5		 5wz1F-1rpnA:
24.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WZ1_F_SAMF601_0
(NS5
METHYLTRANSFERASE)		 4xcq TUBZ
(Clostridium
phage
c-st) 		5 / 12 GLY A  57
GLY A 101
GLY A  59
THR A  95
ILE A  10
 None
GDP  A 401 (-3.3A)
None
GDP  A 401 (-3.0A)
None
 0.93A 5wz1F-4xcqA:
undetectable		 5wz1F-4xcqA:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WZ1_G_SAMG601_0
(NS5
METHYLTRANSFERASE)		 1rpn GDP-MANNOSE
4,6-DEHYDRATASE
(Pseudomonas
aeruginosa) 		5 / 12 GLY A 212
ASP A 215
VAL A 214
ASP A 274
ILE A 273
 GDP  A1601 (-3.3A)
None
None
None
None
 0.92A 5wz1G-1rpnA:
undetectable		 5wz1G-1rpnA:
24.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WZ1_G_SAMG601_0
(NS5
METHYLTRANSFERASE)		 4xcq TUBZ
(Clostridium
phage
c-st) 		5 / 12 GLY A  57
GLY A 101
GLY A  59
THR A  95
ILE A  10
 None
GDP  A 401 (-3.3A)
None
GDP  A 401 (-3.0A)
None
 0.89A 5wz1G-4xcqA:
undetectable		 5wz1G-4xcqA:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WZ1_H_SAMH601_0
(NS5
METHYLTRANSFERASE)		 1rpn GDP-MANNOSE
4,6-DEHYDRATASE
(Pseudomonas
aeruginosa) 		5 / 12 GLY A 212
ASP A 215
VAL A 214
ASP A 274
ILE A 273
 GDP  A1601 (-3.3A)
None
None
None
None
 0.95A 5wz1H-1rpnA:
4.5		 5wz1H-1rpnA:
24.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WZ1_H_SAMH601_0
(NS5
METHYLTRANSFERASE)		 4xcq TUBZ
(Clostridium
phage
c-st) 		5 / 12 GLY A  57
GLY A 101
GLY A  59
THR A  95
ILE A  10
 None
GDP  A 401 (-3.3A)
None
GDP  A 401 (-3.0A)
None
 0.91A 5wz1H-4xcqA:
undetectable		 5wz1H-4xcqA:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X6Y_A_SAMA901_0
(MRNA CAPPING ENZYME
P5)		 5vcu RAS-RELATED C3
BOTULINUM TOXIN
SUBSTRATE 1 ISOFORM
X2
(Naegleria
fowleri) 		5 / 11 VAL A 113
GLY A 114
SER A 158
ALA A 168
LEU A  79
 None
None
GDP  A 301 (-3.5A)
None
None
 1.23A 5x6yA-5vcuA:
2.5		 5x6yA-5vcuA:
12.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X7F_A_SAMA301_0
(PUTATIVE
O-METHYLTRANSFERASE
RV1220C)		 2vaw CELL DIVISION
PROTEIN FTSZ
(Pseudomonas
aeruginosa) 		5 / 12 GLY A 106
GLY A 104
VAL A  19
ALA A 147
ASP A 148
 GDP  A1317 ( 4.0A)
GDP  A1317 (-3.1A)
None
None
None
 1.21A 5x7fA-2vawA:
4.1		 5x7fA-2vawA:
23.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X7P_B_ACRB1421_1
(GLYCOSIDE HYDROLASE
FAMILY 31
ALPHA-GLUCOSIDASE)		 2erx GTP-BINDING PROTEIN
DI-RAS2
(Homo
sapiens) 		4 / 6 TYR A  36
GLU A  34
GLY A  17
GLY A  16
 PO4  A 402 ( 4.4A)
None
GDP  A 401 (-3.3A)
PO4  A 402 (-3.6A)
 0.91A 5x7pB-2erxA:
3.2		 5x7pB-2erxA:
9.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y9M_X_NIOX401_1
(CASEIN KINASE II
SUBUNIT ALPHA')		 3tdw GENTAMICIN
RESISTANCE PROTEIN
(Enterococcus
gallinarum) 		4 / 8 LEU A  27
VAL A  43
ILE A 217
ASP A 218
 GDP  A 500 (-4.4A)
None
GDP  A 500 ( 4.1A)
MG  A 502 (-1.9A)
 0.33A 5y9mX-3tdwA:
9.4		 5y9mX-3tdwA:
12.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y9Y_A_ACTA412_0
(UNCHARACTERIZED
PROTEIN KDOO)		 5vys GDP-MANNOSE
4,6-DEHYDRATASE /
GDP-4-AMINO-4,6-DIDE
OXY-D-MANNOSE
FORMYLTRANSFERASE
(Brucella
melitensis) 		3 / 3 ARG A  88
PHE A 165
ARG A  45
 GDP  A 303 (-3.0A)
GDP  A 303 ( 4.5A)
GDP  A 303 (-2.6A)
 1.14A 5y9yA-5vysA:
undetectable		 5y9yA-5vysA:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YBB_A_SAMA601_0
(TYPE I
RESTRICTION-MODIFICA
TION SYSTEM
METHYLTRANSFERASE
SUBUNIT)		 2vaw CELL DIVISION
PROTEIN FTSZ
(Pseudomonas
aeruginosa) 		5 / 12 GLY A 104
THR A 103
GLY A  23
LEU A 170
PHE A 136
 GDP  A1317 (-3.1A)
None
None
None
None
 1.16A 5ybbA-2vawA:
undetectable		 5ybbA-2vawA:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YBB_A_SAMA601_1
(TYPE I
RESTRICTION-MODIFICA
TION SYSTEM
METHYLTRANSFERASE
SUBUNIT)		 1dj3 ADENYLOSUCCINATE
SYNTHETASE
(Triticum
aestivum) 		4 / 5 PHE A 314
THR A 316
ASP A  30
GLU A 313
 None
None
GDP  A 500 (-4.3A)
None
 1.37A 5ybbA-1dj3A:
0.0		 5ybbA-1dj3A:
23.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YN6_A_SAMA401_0
(NSP16 PROTEIN)		 3wgk CELL DIVISION
PROTEIN FTSZ
(Staphylococcus
aureus) 		5 / 12 GLY A 104
PRO A 115
GLY A 112
ASP A 187
PHE A 183
 GDP  A 400 ( 3.7A)
None
None
GDP  A 400 (-3.0A)
GDP  A 400 (-3.7A)
 1.36A 5yn6A-3wgkA:
undetectable		 5yn6A-3wgkA:
20.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A4I_B_TRPB403_0
(TRYPTOPHAN
2,3-DIOXYGENASE)		 5uzh NAFOA.00085.B
(Naegleria
fowleri) 		4 / 7 ARG A 334
THR A 336
PRO A 335
PRO A 187
 GDP  A 401 (-3.1A)
None
None
None
 1.32A 6a4iB-5uzhA:
undetectable		 6a4iB-5uzhA:
19.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A5Y_D_9CRD501_0
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 5izk SELENOCYSTEINE-SPECI
FIC ELONGATION
FACTOR
(Homo
sapiens) 		5 / 12 ALA A 186
ALA A 185
LEU A  23
ALA A  22
ILE A 181
 GDP  A1001 ( 4.5A)
GDP  A1001 ( 4.4A)
None
GDP  A1001 (-3.8A)
None
 0.91A 6a5yD-5izkA:
undetectable		 6a5yD-5izkA:
9.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AJI_A_AY6A1001_0
(DRUG EXPORTERS OF
THE RND
SUPERFAMILY-LIKE
PROTEIN,ENDOLYSIN)		 1yzg ADP-RIBOSYLATION
FACTOR-LIKE 8
(Homo
sapiens) 		5 / 12 VAL A  91
ILE A  88
ILE A 122
PHE A  12
ALA A 159
 None
None
None
None
GDP  A 181 (-3.3A)
 1.00A 6ajiA-1yzgA:
undetectable		 6ajiA-1yzgA:
11.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AZ3_1_PAR11803_1
(RRNA ALPHA
RIBOSOMAL PROTEIN
EL18)		 2dyk GTP-BINDING PROTEIN
(Thermus
thermophilus) 		3 / 3 SER A  15
LYS A  14
SER A  16
 GDP  A 501 (-2.7A)
GDP  A 501 (-2.7A)
GDP  A 501 (-2.9A)
 0.84A 6az3P-2dykA:
undetectable		 6az3P-2dykA:
16.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AZ3_1_PAR11803_1
(RRNA ALPHA
RIBOSOMAL PROTEIN
EL18)		 2p5s RAS AND EF-HAND
DOMAIN CONTAINING
(Homo
sapiens) 		3 / 3 SER A 555
LYS A 554
SER A 556
 GDP  A1001 ( 2.5A)
GDP  A1001 ( 2.8A)
GDP  A1001 ( 2.6A)
 0.84A 6az3P-2p5sA:
undetectable		 6az3P-2p5sA:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AZ3_1_PAR11803_1
(RRNA ALPHA
RIBOSOMAL PROTEIN
EL18)		 2qu8 PUTATIVE NUCLEOLAR
GTP-BINDING PROTEIN
1
(Plasmodium
falciparum) 		3 / 3 SER A  43
LYS A  42
SER A  44
 GDP  A 229 (-2.9A)
GDP  A 229 (-2.6A)
GDP  A 229 (-2.6A)
 0.83A 6az3P-2qu8A:
undetectable		 6az3P-2qu8A:
17.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AZ3_1_PAR11803_1
(RRNA ALPHA
RIBOSOMAL PROTEIN
EL18)		 3clv RAB5 PROTEIN,
PUTATIVE
(Plasmodium
falciparum) 		3 / 3 SER A  21
LYS A  20
SER A  22
 GDP  A 211 (-2.6A)
GDP  A 211 (-2.8A)
GDP  A 211 (-2.7A)
 0.81A 6az3P-3clvA:
undetectable		 6az3P-3clvA:
19.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AZ3_1_PAR11803_1
(RRNA ALPHA
RIBOSOMAL PROTEIN
EL18)		 5yew MITOFUSIN-1,MITOFUSI
N-1 FUSION PROTEIN
(Homo
sapiens) 		3 / 3 SER B  89
LYS B  88
SER B  90
 MG  B 804 ( 2.1A)
BEF  B 802 ( 2.5A)
GDP  B 801 (-2.5A)
 0.83A 6az3P-5yewB:
undetectable		 6az3P-5yewB:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B58_A_ACTA607_0
(FUMARATE REDUCTASE
FLAVOPROTEIN SUBUNIT)		 5kx6 GALACTOSIDE
2-ALPHA-L-FUCOSYLTRA
NSFERASE
(Arabidopsis
thaliana) 		4 / 4 GLY A 461
ARG A 185
ASN A 460
LEU A 464
 None
None
GDP  A 601 ( 4.8A)
None
 1.16A 6b58A-5kx6A:
undetectable		 6b58A-5kx6A:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BPL_B_PA1B605_1
(LIPID A EXPORT
ATP-BINDING/PERMEASE
PROTEIN MSBA)		 5uzh NAFOA.00085.B
(Naegleria
fowleri) 		3 / 3 ARG A 334
ARG A 223
ARG A 256
 GDP  A 401 (-3.1A)
NAP  A 402 (-3.3A)
GDP  A 401 (-3.4A)
 0.97A 6bplA-5uzhA:
undetectable
6bplB-5uzhA:
undetectable		 6bplA-5uzhA:
13.04
6bplB-5uzhA:
13.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BQ4_B_ADNB401_1
(THERMOSPERMINE
SYNTHASE ACAULIS
PROTEIN)		 2e87 HYPOTHETICAL PROTEIN
PH1320
(Pyrococcus
horikoshii) 		5 / 12 GLY A 179
ILE A 172
VAL A 286
ASP A 220
ALA A 186
 GDP  A 400 (-3.1A)
None
None
None
None
 1.04A 6bq4B-2e87A:
undetectable		 6bq4B-2e87A:
13.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BXN_A_SAMA901_0
(DIPHTHAMIDE
BIOSYNTHESIS ENZYME
DPH2)		 4v0k ARF-LIKE SMALL
GTPASE
(Chlamydomonas
reinhardtii) 		5 / 12 PHE A 126
LEU A 163
VAL A  22
ARG A  36
ILE A  34
 None
GDP  A 700 (-4.4A)
None
None
None
 1.35A 6bxnA-4v0kA:
2.0		 6bxnA-4v0kA:
18.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BXN_B_SAMB901_0
(DIPHTHAMIDE
BIOSYNTHESIS ENZYME
DPH2)		 4v0k ARF-LIKE SMALL
GTPASE
(Chlamydomonas
reinhardtii) 		5 / 12 PHE A 126
LEU A 163
VAL A  22
ARG A  36
ILE A  34
 None
GDP  A 700 (-4.4A)
None
None
None
 1.39A 6bxnB-4v0kA:
undetectable		 6bxnB-4v0kA:
18.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BZO_C_FI8C1201_0
(DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA)		 1xje RIBONUCLEOTIDE
REDUCTASE,
B12-DEPENDENT
(Thermotoga
maritima) 		5 / 12 ILE A 625
THR A 319
VAL A 136
GLU A 324
GLU A 505
 None
None
None
GDP  A1002 (-2.6A)
None
 1.41A 6bzoC-1xjeA:
0.5		 6bzoC-1xjeA:
18.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6C2M_B_SUEB1202_1
(NS3 PROTEASE)		 2r6r CELL DIVISION
PROTEIN FTSZ
(Aquifex
aeolicus) 		5 / 9 VAL 1 182
ASP 1 183
LEU 1 101
ALA 1  99
VAL 1  15
 GDP  1 339 (-4.3A)
GDP  1 339 (-3.2A)
None
None
None
 1.23A 6c2mB-2r6r1:
undetectable		 6c2mB-2r6r1:
14.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6C2M_D_SUED1202_1
(NS3 PROTEASE)		 2r6r CELL DIVISION
PROTEIN FTSZ
(Aquifex
aeolicus) 		4 / 9 VAL 1 182
ASP 1 183
LEU 1 101
VAL 1  15
 GDP  1 339 (-4.3A)
GDP  1 339 (-3.2A)
None
None
 0.97A 6c2mD-2r6r1:
undetectable		 6c2mD-2r6r1:
14.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6C2M_D_SUED1202_1
(NS3 PROTEASE)		 3c7k GUANINE
NUCLEOTIDE-BINDING
PROTEIN G(O) SUBUNIT
ALPHA
(Mus
musculus) 		4 / 9 VAL A 111
ASP A 116
LEU A 149
SER A 152
 None
None
None
GDP  A 361 (-3.2A)
 0.96A 6c2mD-3c7kA:
undetectable		 6c2mD-3c7kA:
12.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CB4_A_BEZA501_0
(CANAVALIN)		 5vgr ATLASTIN-3
(Homo
sapiens) 		4 / 8 ASN A 173
VAL A  65
ILE A 171
ARG A 213
 None
None
None
GDP  A 501 (-3.7A)
 0.79A 6cb4A-5vgrA:
undetectable		 6cb4A-5vgrA:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CNJ_D_NCTD402_1
(NEURONAL
ACETYLCHOLINE
RECEPTOR SUBUNIT
ALPHA-4
NEURONAL
ACETYLCHOLINE
RECEPTOR SUBUNIT
BETA-2)		 1dj2 ADENYLOSUCCINATE
SYNTHETASE
(Arabidopsis
thaliana) 		4 / 8 TYR A 416
THR A 348
TYR A 287
TRP A 396
 None
GDP  A 500 ( 4.9A)
None
None
 1.38A 6cnjD-1dj2A:
undetectable
6cnjE-1dj2A:
undetectable		 6cnjD-1dj2A:
11.42
6cnjE-1dj2A:
10.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CNJ_D_NCTD402_1
(NEURONAL
ACETYLCHOLINE
RECEPTOR SUBUNIT
ALPHA-4
NEURONAL
ACETYLCHOLINE
RECEPTOR SUBUNIT
BETA-2)		 1p9b ADENYLOSUCCINATE
SYNTHETASE
(Plasmodium
falciparum) 		4 / 8 TYR A 409
THR A 338
TYR A 277
TRP A 389
 None
GDP  A1603 ( 4.9A)
None
None
 1.43A 6cnjD-1p9bA:
0.0
6cnjE-1p9bA:
undetectable		 6cnjD-1p9bA:
12.50
6cnjE-1p9bA:
10.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CNJ_D_NCTD402_1
(NEURONAL
ACETYLCHOLINE
RECEPTOR SUBUNIT
ALPHA-4
NEURONAL
ACETYLCHOLINE
RECEPTOR SUBUNIT
BETA-2)		 2v40 ADENYLOSUCCINATE
SYNTHETASE ISOZYME 2
(Homo
sapiens) 		4 / 8 TYR A 428
THR A 361
TYR A 300
TRP A 408
 None
GDP  A1457 ( 4.6A)
None
None
 1.34A 6cnjD-2v40A:
undetectable
6cnjE-2v40A:
undetectable		 6cnjD-2v40A:
12.85
6cnjE-2v40A:
10.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DEB_B_MTXB303_1
(BIFUNCTIONAL PROTEIN
FOLD)		 4b46 CELL DIVISION
PROTEIN FTSZ
(Haloferax
volcanii) 		4 / 5 TYR A 183
GLN A 180
GLY A 112
ILE A 136
 GDP  A1368 (-3.5A)
None
GDP  A1368 (-3.5A)
GDP  A1368 ( 4.2A)
 1.22A 6debB-4b46A:
2.1		 6debB-4b46A:
12.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DWD_A_GLYA715_0
(DEOXYNUCLEOSIDE
TRIPHOSPHATE
TRIPHOSPHOHYDROLASE
SAMHD1)		 5kxq GDP-FUCOSE PROTEIN
O-FUCOSYLTRANSFERASE
1
(Mus
musculus) 		4 / 6 GLY A  50
ASN A  51
ASP A  54
SER A 269
 GDP  A 403 (-3.3A)
None
None
None
 1.21A 6dwdA-5kxqA:
undetectable
6dwdC-5kxqA:
undetectable		 6dwdA-5kxqA:
21.47
6dwdC-5kxqA:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6E8Q_A_X2NA602_0
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 2qag SEPTIN-2
(Homo
sapiens) 		5 / 12 GLY A 241
PHE A 167
ILE A 171
THR A  98
THR A  52
 None
None
None
None
GDP  A 362 (-3.9A)
 1.18A 6e8qA-2qagA:
undetectable		 6e8qA-2qagA:
16.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ECT_A_SAMA1300_0
(STIE PROTEIN)		 3zbq PHIKZ039
(Pseudomonas
virus
phiKZ) 		5 / 12 GLY A  16
GLY A  14
ILE A 132
GLU A  21
ILE A 182
 None
GDP  A 999 (-3.3A)
GDP  A 999 (-4.1A)
None
None
 0.96A 6ectA-3zbqA:
undetectable		 6ectA-3zbqA:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ECX_A_SAMA1301_0
(STIE PROTEIN)		 3zbq PHIKZ039
(Pseudomonas
virus
phiKZ) 		5 / 12 GLY A  16
GLY A  14
ILE A 132
GLU A  21
ILE A 182
 None
GDP  A 999 (-3.3A)
GDP  A 999 (-4.1A)
None
None
 0.93A 6ecxA-3zbqA:
3.1		 6ecxA-3zbqA:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EXI_A_ADNA503_1
(ADENOSYLHOMOCYSTEINA
SE)		 2cjw GTP-BINDING PROTEIN
GEM
(Homo
sapiens) 		3 / 3 LEU A 171
GLN A 174
LYS A  88
 None
None
GDP  A 999 (-2.7A)
 0.83A 6exiB-2cjwA:
undetectable		 6exiB-2cjwA:
20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EXI_A_ADNA503_1
(ADENOSYLHOMOCYSTEINA
SE)		 2nzj GTP-BINDING PROTEIN
REM 1
(Homo
sapiens) 		3 / 3 LEU A 175
GLN A 178
LYS A  93
 None
None
GDP  A1001 (-3.0A)
 0.96A 6exiB-2nzjA:
4.0		 6exiB-2nzjA:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EXI_B_ADNB503_0
(ADENOSYLHOMOCYSTEINA
SE)		 2cjw GTP-BINDING PROTEIN
GEM
(Homo
sapiens) 		3 / 3 LEU A 171
GLN A 174
LYS A  88
 None
None
GDP  A 999 (-2.7A)
 0.84A 6exiA-2cjwA:
2.3		 6exiA-2cjwA:
20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EXI_B_ADNB503_0
(ADENOSYLHOMOCYSTEINA
SE)		 2nzj GTP-BINDING PROTEIN
REM 1
(Homo
sapiens) 		3 / 3 LEU A 175
GLN A 178
LYS A  93
 None
None
GDP  A1001 (-3.0A)
 0.94A 6exiA-2nzjA:
3.9		 6exiA-2nzjA:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F3M_D_ADND502_2
(-)		 1xje RIBONUCLEOTIDE
REDUCTASE,
B12-DEPENDENT
(Thermotoga
maritima) 		4 / 5 ILE A 494
THR A 491
THR A  93
LEU A 365
 GDP  A1002 (-3.9A)
GDP  A1002 (-4.7A)
None
None
 1.08A 6f3mD-1xjeA:
undetectable		 6f3mD-1xjeA:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F88_A_STRA502_1
(CYTOCHROME P450
CYP260A1)		 4m8n PLEXINC1
INTRACELLULAR REGION
RAS-RELATED PROTEIN
RAP-1B
(Danio
rerio;
Homo
sapiens) 		4 / 6 PHE E  28
ALA E  18
THR E  85
ASN A 705
 GDP  E 201 (-4.7A)
GDP  E 201 (-3.2A)
None
None
 0.96A 6f88A-4m8nE:
undetectable		 6f88A-4m8nE:
16.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FBP_B_ADNB404_0
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)		 5vgr ATLASTIN-3
(Homo
sapiens) 		5 / 12 ASP A  78
ILE A  76
ILE A 297
PRO A 268
PHE A  79
 None
None
None
GDP  A 501 (-4.0A)
None
 1.41A 6fbpA-5vgrA:
undetectable
6fbpB-5vgrA:
undetectable		 6fbpA-5vgrA:
13.28
6fbpB-5vgrA:
13.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FGC_A_ACTA811_0
(GEPHYRIN)		 3x1d ATLASTIN
(Drosophila
melanogaster) 		3 / 3 LEU A 275
LEU A  54
ARG A 192
 None
None
GDP  A 601 (-4.4A)
 0.70A 6fgcA-3x1dA:
2.6		 6fgcA-3x1dA:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNE_A_ACRA602_1
(-)		 4n9w GDP-MANNOSE-DEPENDEN
T
ALPHA-(1-2)-PHOSPHAT
IDYLINOSITOL
MANNOSYLTRANSFERASE
(Mycolicibacteriu
m
smegmatis) 		5 / 12 GLY A  15
GLY A  16
VAL A 147
ASN A 168
GLY A 277
 GDP  A 401 (-3.6A)
GDP  A 401 (-3.7A)
None
None
None
 0.94A 6gneA-4n9wA:
24.5		 6gneA-4n9wA:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNE_B_ACRB602_1
(-)		 4n9w GDP-MANNOSE-DEPENDEN
T
ALPHA-(1-2)-PHOSPHAT
IDYLINOSITOL
MANNOSYLTRANSFERASE
(Mycolicibacteriu
m
smegmatis) 		5 / 12 GLY A  15
GLY A  16
VAL A 147
ASN A 168
GLY A 277
 GDP  A 401 (-3.6A)
GDP  A 401 (-3.7A)
None
None
None
 0.94A 6gneB-4n9wA:
24.5		 6gneB-4n9wA:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNE_B_ACRB602_2
(-)		 1d2e ELONGATION FACTOR TU
(EF-TU)
(Bos
taurus) 		4 / 8 VAL A 192
HIS A  68
ASN A 181
TYR A 179
 None
None
GDP  A1301 (-3.1A)
None
 1.22A 6gneB-1d2eA:
2.5		 6gneB-1d2eA:
20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MHT_D_SAMD328_0
(CYTOSINE-SPECIFIC
METHYLTRANSFERASE
HHAI)		 4b46 CELL DIVISION
PROTEIN FTSZ
(Haloferax
volcanii) 		5 / 12 PHE A 167
GLY A 135
ASN A 169
ILE A 186
VAL A 228
 None
None
GDP  A1368 (-3.3A)
GDP  A1368 (-4.2A)
None
 1.10A 6mhtA-4b46A:
3.2		 6mhtA-4b46A:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN5_D_LLLD301_0
(AMINOGLYCOSIDE
N(3)-ACETYLTRANSFERA
SE, AAC(3)-IVA)		 2dyk GTP-BINDING PROTEIN
(Thermus
thermophilus) 		4 / 6 ASP A  88
ARG A  90
ASP A 119
GLU A 144
 None
GDP  A 501 (-3.4A)
GDP  A 501 (-2.8A)
None
 1.18A 6mn5D-2dykA:
undetectable		 6mn5D-2dykA:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN5_E_LLLE301_0
(AMINOGLYCOSIDE
N(3)-ACETYLTRANSFERA
SE, AAC(3)-IVA)		 2dyk GTP-BINDING PROTEIN
(Thermus
thermophilus) 		4 / 7 ASP A  88
ARG A  90
ASP A 119
GLU A 144
 None
GDP  A 501 (-3.4A)
GDP  A 501 (-2.8A)
None
 1.35A 6mn5E-2dykA:
undetectable		 6mn5E-2dykA:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NQA_K_SAMK500_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-79
SPECIFIC)		 2r6r CELL DIVISION
PROTEIN FTSZ
(Aquifex
aeolicus) 		5 / 10 THR 1 105
GLY 1  64
GLY 1  58
GLU 1  59
ASN 1  40
 GDP  1 339 (-4.3A)
None
None
None
GDP  1 339 ( 4.4A)
 1.28A 6nqaK-2r6r1:
undetectable		 6nqaK-2r6r1:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NQA_K_SAMK500_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-79
SPECIFIC)		 4b46 CELL DIVISION
PROTEIN FTSZ
(Haloferax
volcanii) 		5 / 10 THR A 111
GLY A  65
GLY A  59
VAL A  68
ASN A  38
 GDP  A1368 (-4.3A)
None
None
None
GDP  A1368 ( 4.2A)
 1.42A 6nqaK-4b46A:
undetectable		 6nqaK-4b46A:
21.78