SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'GDL'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2W4X_A_STZA1591_1 (O-GLCNACASE BT_4395)	2xsb	HYALURONOGLUCOSAMINI DASE (Oceanicola granulosus)	9 / 11	ASP A 115 CYH A 156 TYR A 160 THR A 191 TRP A 219 ASN A 221 ASP A 226 TYR A 227 ASN A 254	None GDL A1436 ( 3.9A) GDL A1436 (-3.6A) GDL A1436 ( 4.5A) GDL A1436 (-3.6A) GDL A1436 (-3.0A) GDL A1436 (-3.0A) GDL A1436 (-4.8A) GDL A1436 (-3.4A)	0.49A	2w4xA-2xsbA: 31.3	2w4xA-2xsbA: 23.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2X0Y_A_X0TA1625_1 (O-GLCNACASE NAGJ)	2xsb	HYALURONOGLUCOSAMINI DASE (Oceanicola granulosus)	8 / 12	LYS A 39 ASP A 115 TYR A 160 THR A 191 TRP A 219 ASN A 221 ASP A 226 ASN A 254	GDL A1436 ( 3.8A) None GDL A1436 (-3.6A) GDL A1436 ( 4.5A) GDL A1436 (-3.6A) GDL A1436 (-3.0A) GDL A1436 (-3.0A) GDL A1436 (-3.4A)	0.42A	2x0yA-2xsbA: 38.6	2x0yA-2xsbA: 21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2X0Y_B_X0TB1625_1 (O-GLCNACASE NAGJ)	2xsb	HYALURONOGLUCOSAMINI DASE (Oceanicola granulosus)	9 / 12	LYS A 39 ASP A 115 TYR A 160 THR A 191 TRP A 219 ASN A 221 ASP A 226 TYR A 227 ASN A 254	GDL A1436 ( 3.8A) None GDL A1436 (-3.6A) GDL A1436 ( 4.5A) GDL A1436 (-3.6A) GDL A1436 (-3.0A) GDL A1436 (-3.0A) GDL A1436 (-4.8A) GDL A1436 (-3.4A)	0.52A	2x0yB-2xsbA: 39.7	2x0yB-2xsbA: 21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5UMD_A_YMZA3801_1 (60S RIBOSOMAL PROTEIN L28 28S RIBOSOMAL RNA 60S RIBOSOMAL PROTEIN L4)	2xsb	HYALURONOGLUCOSAMINI DASE (Oceanicola granulosus)	5 / 6	ASN A 225 ALA A 224 PRO A 319 ASP A 226 TYR A 227	None GDL A1436 ( 3.9A) None GDL A1436 (-3.0A) GDL A1436 (-4.8A)	1.46A	5umd2-2xsbA: undetectable 5umdF-2xsbA: undetectable	5umd2-2xsbA: 9.01 5umdF-2xsbA: 12.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5ZV2_A_LEVA801_2 (FIBROBLAST GROWTH FACTOR RECEPTOR 1)	2xsb	HYALURONOGLUCOSAMINI DASE (Oceanicola granulosus)	3 / 3	LYS A 39 LEU A 82 ASP A 115	GDL A1436 ( 3.8A) None None	0.83A	5zv2A-2xsbA: undetectable	5zv2A-2xsbA: 11.56

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["2W4X_A_STZA1591_1","O-GLCNACASE BT_4395","2xsb","HYALURONOGLUCOSAMINIDASE","Oceanicola granulosus",9,"ASP A 115;CYH A 156;TYR A 160;THR A 191;TRP A 219;ASN A 221;ASP A 226;TYR A 227;ASN A 254","None;GDL A1436 ( 3.9A);GDL A1436 (-3.6A);GDL A1436 ( 4.5A);GDL A1436 (-3.6A);GDL A1436 (-3.0A);GDL A1436 (-3.0A);GDL A1436 (-4.8A);GDL A1436 (-3.4A)","0.49A","2w4xA-2xsbA:31.3",null],["2X0Y_A_X0TA1625_1","O-GLCNACASE NAGJ","2xsb","HYALURONOGLUCOSAMINIDASE","Oceanicola granulosus",8,"LYS A  39;ASP A 115;TYR A 160;THR A 191;TRP A 219;ASN A 221;ASP A 226;ASN A 254","GDL A1436 ( 3.8A);None;GDL A1436 (-3.6A);GDL A1436 ( 4.5A);GDL A1436 (-3.6A);GDL A1436 (-3.0A);GDL A1436 (-3.0A);GDL A1436 (-3.4A)","0.42A","2x0yA-2xsbA:38.6","2w4xA-2xsbA:23.63"],["2X0Y_B_X0TB1625_1","O-GLCNACASE NAGJ","2xsb","HYALURONOGLUCOSAMINIDASE","Oceanicola granulosus",9,"LYS A  39;ASP A 115;TYR A 160;THR A 191;TRP A 219;ASN A 221;ASP A 226;TYR A 227;ASN A 254","GDL A1436 ( 3.8A);None;GDL A1436 (-3.6A);GDL A1436 ( 4.5A);GDL A1436 (-3.6A);GDL A1436 (-3.0A);GDL A1436 (-3.0A);GDL A1436 (-4.8A);GDL A1436 (-3.4A)","0.52A","2x0yB-2xsbA:39.7","2x0yA-2xsbA:21.70"],["5UMD_A_YMZA3801_1","60S RIBOSOMAL PROTEIN L28;28S RIBOSOMAL RNA;60S RIBOSOMAL PROTEIN L4","2xsb","HYALURONOGLUCOSAMINIDASE","Oceanicola granulosus",5,"ASN A 225;ALA A 224;PRO A 319;ASP A 226;TYR A 227","None;GDL A1436 ( 3.9A);None;GDL A1436 (-3.0A);GDL A1436 (-4.8A)","1.46A","5umd2-2xsbA:undetectable;5umdF-2xsbA:undetectable","2x0yB-2xsbA:21.70"],["5ZV2_A_LEVA801_2","FIBROBLAST GROWTH FACTOR RECEPTOR 1","2xsb","HYALURONOGLUCOSAMINIDASE","Oceanicola granulosus",3,"LYS A  39;LEU A  82;ASP A 115","GDL A1436 ( 3.8A);None;None","0.83A","5zv2A-2xsbA:undetectable","5umd2-2xsbA:9.01;5umdF-2xsbA:12.04"]]