SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'GDD'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HK1_A_T44A3003_1
(SERUM ALBUMIN)		 2wvl MANNOSYL-3-PHOSPHOGL
YCERATE SYNTHASE
(Thermus
thermophilus) 		4 / 6 HIS A 318
ILE A 319
ALA A 351
VAL A 221
 GDD  A 400 ( 4.9A)
None
None
None
 1.02A 1hk1A-2wvlA:
2.6		 1hk1A-2wvlA:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KXH_A_ACRA598_1
(ALPHA-AMYLASE)		 3o3p MANNOSYL-3-PHOSPHOGL
YCERATE SYNTHASE
(Rubrobacter
xylanophilus) 		5 / 12 VAL A 149
GLY A 148
ALA A 208
GLU A 230
ILE A 233
 None
None
None
GDD  A 340 (-3.9A)
None
 1.15A 1kxhA-3o3pA:
undetectable		 1kxhA-3o3pA:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJ2_A_SAMA2201_0
(PROTEIN (METHIONINE
REPRESSOR))		 3o3p MANNOSYL-3-PHOSPHOGL
YCERATE SYNTHASE
(Rubrobacter
xylanophilus) 		5 / 9 GLU A 210
ARG A 254
ALA A  46
LEU A  48
PRO A  49
 None
MG  A 339 ( 4.7A)
None
None
GDD  A 340 (-4.8A)
 1.06A 1mj2A-3o3pA:
undetectable		 1mj2A-3o3pA:
15.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJO_A_SAMA199_0
(METHIONINE REPRESSOR)		 3o3p MANNOSYL-3-PHOSPHOGL
YCERATE SYNTHASE
(Rubrobacter
xylanophilus) 		5 / 9 GLU A 210
ARG A 254
ALA A  46
LEU A  48
PRO A  49
 None
MG  A 339 ( 4.7A)
None
None
GDD  A 340 (-4.8A)
 1.08A 1mjoA-3o3pA:
undetectable		 1mjoA-3o3pA:
15.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJO_B_SAMB200_1
(METHIONINE REPRESSOR)		 3o3p MANNOSYL-3-PHOSPHOGL
YCERATE SYNTHASE
(Rubrobacter
xylanophilus) 		5 / 9 GLU A 210
ARG A 254
ALA A  46
LEU A  48
PRO A  49
 None
MG  A 339 ( 4.7A)
None
None
GDD  A 340 (-4.8A)
 1.07A 1mjoB-3o3pA:
undetectable		 1mjoB-3o3pA:
15.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NV8_A_SAMA300_0
(HEMK PROTEIN)		 3o3p MANNOSYL-3-PHOSPHOGL
YCERATE SYNTHASE
(Rubrobacter
xylanophilus) 		5 / 12 PRO A  49
GLY A 226
GLY A 116
VAL A 323
ALA A 112
 GDD  A 340 (-4.8A)
None
None
None
None
 0.88A 1nv8A-3o3pA:
undetectable		 1nv8A-3o3pA:
23.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SG9_B_SAMB302_0
(HEMK PROTEIN)		 3o3p MANNOSYL-3-PHOSPHOGL
YCERATE SYNTHASE
(Rubrobacter
xylanophilus) 		6 / 12 PRO A  49
GLY A 226
GLY A 116
VAL A 323
GLU A 321
ALA A 112
 GDD  A 340 (-4.8A)
None
None
None
None
None
 1.09A 1sg9B-3o3pA:
undetectable		 1sg9B-3o3pA:
23.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SG9_C_SAMC303_0
(HEMK PROTEIN)		 3o3p MANNOSYL-3-PHOSPHOGL
YCERATE SYNTHASE
(Rubrobacter
xylanophilus) 		5 / 12 PRO A  49
GLY A 116
VAL A 323
GLU A 321
ALA A 112
 GDD  A 340 (-4.8A)
None
None
None
None
 1.03A 1sg9C-3o3pA:
undetectable		 1sg9C-3o3pA:
23.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A58_B_RBFB301_1
(6,7-DIMETHYL-8-RIBIT
YLLUMAZINE SYNTHASE)		 2wvl MANNOSYL-3-PHOSPHOGL
YCERATE SYNTHASE
(Thermus
thermophilus) 		5 / 12 ILE A 149
LEU A 150
GLY A 143
SER A 142
GLU A 146
 None
None
GDD  A 400 (-3.1A)
GDD  A 400 ( 4.9A)
None
 1.22A 2a58A-2wvlA:
2.2
2a58B-2wvlA:
2.2		 2a58A-2wvlA:
18.60
2a58B-2wvlA:
18.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A58_C_RBFC302_1
(6,7-DIMETHYL-8-RIBIT
YLLUMAZINE SYNTHASE)		 2wvl MANNOSYL-3-PHOSPHOGL
YCERATE SYNTHASE
(Thermus
thermophilus) 		5 / 12 ILE A 149
LEU A 150
GLY A 143
SER A 142
GLU A 146
 None
None
GDD  A 400 (-3.1A)
GDD  A 400 ( 4.9A)
None
 1.22A 2a58B-2wvlA:
2.2
2a58C-2wvlA:
2.5		 2a58B-2wvlA:
18.60
2a58C-2wvlA:
18.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A58_E_RBFE304_1
(6,7-DIMETHYL-8-RIBIT
YLLUMAZINE SYNTHASE)		 2wvl MANNOSYL-3-PHOSPHOGL
YCERATE SYNTHASE
(Thermus
thermophilus) 		5 / 12 ILE A 149
LEU A 150
GLY A 143
SER A 142
GLU A 146
 None
None
GDD  A 400 (-3.1A)
GDD  A 400 ( 4.9A)
None
 1.22A 2a58D-2wvlA:
undetectable
2a58E-2wvlA:
2.2		 2a58D-2wvlA:
18.60
2a58E-2wvlA:
18.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2O7O_A_DXTA222_1
(TETRACYCLINE
REPRESSOR PROTEIN
CLASS D)		 2pk3 GDP-6-DEOXY-D-LYXO-4
-HEXULOSE REDUCTASE
(Aneurinibacillus
thermoaerophilus) 		5 / 12 ASN A 169
PHE A 168
THR A 242
VAL A 208
SER A 115
 GDD  A 410 (-3.1A)
None
None
None
GDD  A 410 (-2.4A)
 1.42A 2o7oA-2pk3A:
undetectable		 2o7oA-2pk3A:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XRL_A_DXTA1211_1
(TETRACYCLINE
REPRESSOR PROTEIN
CLASS D)		 2pk3 GDP-6-DEOXY-D-LYXO-4
-HEXULOSE REDUCTASE
(Aneurinibacillus
thermoaerophilus) 		5 / 12 ASN A 169
PHE A 168
THR A 242
VAL A 208
SER A 115
 GDD  A 410 (-3.1A)
None
None
None
GDD  A 410 (-2.4A)
 1.48A 2xrlA-2pk3A:
undetectable		 2xrlA-2pk3A:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ID5_B_SAMB301_0
(FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE)		 3o3p MANNOSYL-3-PHOSPHOGL
YCERATE SYNTHASE
(Rubrobacter
xylanophilus) 		5 / 11 GLY A  58
ASP A 137
ALA A 136
ASP A  62
ILE A  60
 None
MG  A 339 ( 2.5A)
GDD  A 340 (-3.6A)
None
None
 1.32A 3id5B-3o3pA:
undetectable		 3id5B-3o3pA:
19.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ID5_F_SAMF301_0
(FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE)		 3o3p MANNOSYL-3-PHOSPHOGL
YCERATE SYNTHASE
(Rubrobacter
xylanophilus) 		5 / 11 GLY A  58
ASP A 137
ALA A 136
ASP A  62
ILE A  60
 None
MG  A 339 ( 2.5A)
GDD  A 340 (-3.6A)
None
None
 1.31A 3id5F-3o3pA:
undetectable		 3id5F-3o3pA:
19.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PP7_B_SVRB499_1
(PYRUVATE KINASE)		 3o3p MANNOSYL-3-PHOSPHOGL
YCERATE SYNTHASE
(Rubrobacter
xylanophilus) 		5 / 10 PRO A 206
ARG A 254
GLY A 180
GLY A 209
ALA A 208
 None
MG  A 339 ( 4.7A)
None
GDD  A 340 (-3.5A)
None
 1.36A 3pp7B-3o3pA:
5.0		 3pp7B-3o3pA:
23.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PRS_A_RITA1001_2
(ENDOTHIAPEPSIN)		 3o3p MANNOSYL-3-PHOSPHOGL
YCERATE SYNTHASE
(Rubrobacter
xylanophilus) 		5 / 12 ASP A 137
ASP A 135
GLY A 209
GLY A 116
PHE A 211
 MG  A 339 ( 2.5A)
GDD  A 340 (-3.2A)
GDD  A 340 (-3.5A)
None
None
 0.83A 3prsA-3o3pA:
undetectable		 3prsA-3o3pA:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C5L_A_UEGA300_1
(PHOSPHOMETHYLPYRIMID
INE KINASE)		 3o3p MANNOSYL-3-PHOSPHOGL
YCERATE SYNTHASE
(Rubrobacter
xylanophilus) 		5 / 11 GLY A 226
ASP A 117
ALA A 112
GLY A 114
VAL A 323
 None
None
None
GDD  A 340 (-3.2A)
None
 1.19A 4c5lA-3o3pA:
undetectable		 4c5lA-3o3pA:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C5L_B_PXLB300_1
(PHOSPHOMETHYLPYRIMID
INE KINASE)		 3o3p MANNOSYL-3-PHOSPHOGL
YCERATE SYNTHASE
(Rubrobacter
xylanophilus) 		5 / 9 GLY A 226
ASP A 117
ALA A 112
GLY A 114
VAL A 323
 None
None
None
GDD  A 340 (-3.2A)
None
 1.21A 4c5lB-3o3pA:
undetectable		 4c5lB-3o3pA:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C5L_C_UEGC300_1
(PHOSPHOMETHYLPYRIMID
INE KINASE)		 3o3p MANNOSYL-3-PHOSPHOGL
YCERATE SYNTHASE
(Rubrobacter
xylanophilus) 		5 / 10 GLY A 226
ASP A 117
ALA A 112
GLY A 114
VAL A 323
 None
None
None
GDD  A 340 (-3.2A)
None
 1.20A 4c5lC-3o3pA:
undetectable		 4c5lC-3o3pA:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C5L_D_UEGD300_1
(PHOSPHOMETHYLPYRIMID
INE KINASE)		 3o3p MANNOSYL-3-PHOSPHOGL
YCERATE SYNTHASE
(Rubrobacter
xylanophilus) 		5 / 10 GLY A 226
ASP A 117
ALA A 112
GLY A 114
VAL A 323
 None
None
None
GDD  A 340 (-3.2A)
None
 1.21A 4c5lD-3o3pA:
undetectable		 4c5lD-3o3pA:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C5N_B_PXLB300_1
(PHOSPHOMETHYLPYRIMID
INE KINASE)		 3o3p MANNOSYL-3-PHOSPHOGL
YCERATE SYNTHASE
(Rubrobacter
xylanophilus) 		5 / 10 GLY A 226
ASP A 117
ALA A 112
GLY A 114
VAL A 323
 None
None
None
GDD  A 340 (-3.2A)
None
 1.21A 4c5nB-3o3pA:
undetectable		 4c5nB-3o3pA:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C5N_D_UEGD300_1
(PHOSPHOMETHYLPYRIMID
INE KINASE)		 3o3p MANNOSYL-3-PHOSPHOGL
YCERATE SYNTHASE
(Rubrobacter
xylanophilus) 		5 / 10 GLY A 226
ASP A 117
ALA A 112
GLY A 114
VAL A 323
 None
None
None
GDD  A 340 (-3.2A)
None
 1.22A 4c5nD-3o3pA:
undetectable		 4c5nD-3o3pA:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V2G_B_CTCB222_0
(TETRACYCLINE
REPRESSOR PROTEIN
CLASS D)		 2pk3 GDP-6-DEOXY-D-LYXO-4
-HEXULOSE REDUCTASE
(Aneurinibacillus
thermoaerophilus) 		5 / 12 ASN A 169
PHE A 168
THR A 242
VAL A 208
SER A 115
 GDD  A 410 (-3.1A)
None
None
None
GDD  A 410 (-2.4A)
 1.43A 4v2gB-2pk3A:
0.0		 4v2gB-2pk3A:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NWV_A_ACAA18_1
(SCRFP-TAG,GP41)		 2wvl MANNOSYL-3-PHOSPHOGL
YCERATE SYNTHASE
(Thermus
thermophilus) 		5 / 12 GLY A  75
SER A  74
GLU A  64
LEU A  69
GLU A  70
 None
None
GDD  A 400 (-3.7A)
None
None
 1.21A 5nwvA-2wvlA:
undetectable		 5nwvA-2wvlA:
8.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5PAH_A_LDPA600_1
(PHENYLALANINE
4-MONOOXYGENASE)		 2zu8 MANNOSYL-3-PHOSPHOGL
YCERATE SYNTHASE
(Pyrococcus
horikoshii) 		4 / 4 HIS A 312
HIS A 310
TYR A 180
GLU A 251
 GDD  A 395 (-3.6A)
GDD  A 395 ( 4.6A)
None
None
 1.29A 5pahA-2zu8A:
undetectable		 5pahA-2zu8A:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5PHH_A_LDPA414_1
(LYSINE-SPECIFIC
DEMETHYLASE 4D)		 3oka GDP-MANNOSE-DEPENDEN
T
ALPHA-(1-6)-PHOSPHAT
IDYLINOSITOL
MONOMANNOSIDE
MANNOSYLTRANSFERASE
(Corynebacterium
glutamicum) 		4 / 6 GLU A 290
ARG A 210
TYR A 296
SER A 205
 GDD  A 701 ( 4.2A)
SO4  A 601 ( 4.1A)
None
GDD  A 701 ( 4.1A)
 1.11A 5phhA-3okaA:
undetectable		 5phhA-3okaA:
20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YCP_A_BRLA501_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 3o3p MANNOSYL-3-PHOSPHOGL
YCERATE SYNTHASE
(Rubrobacter
xylanophilus) 		3 / 3 GLY A 182
VAL A 271
MET A 267
 None
None
GDD  A 340 (-3.4A)
 0.60A 5ycpA-3o3pA:
undetectable		 5ycpA-3o3pA:
11.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6H1L_A_FJQA501_0
(BIFUNCTIONAL
CYTOCHROME
P450/NADPH--P450
REDUCTASE)		 2zu8 MANNOSYL-3-PHOSPHOGL
YCERATE SYNTHASE
(Pyrococcus
horikoshii) 		5 / 10 ALA A 169
VAL A  55
ILE A 112
ALA A  73
LEU A  71
 GDD  A 395 (-3.6A)
None
None
None
None
 1.25A 6h1lA-2zu8A:
undetectable		 6h1lA-2zu8A:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6H1L_B_FJQB501_0
(BIFUNCTIONAL
CYTOCHROME
P450/NADPH--P450
REDUCTASE)		 2zu8 MANNOSYL-3-PHOSPHOGL
YCERATE SYNTHASE
(Pyrococcus
horikoshii) 		5 / 11 ALA A 169
VAL A  55
ILE A 112
ALA A  73
LEU A  71
 GDD  A 395 (-3.6A)
None
None
None
None
 1.26A 6h1lB-2zu8A:
undetectable		 6h1lB-2zu8A:
22.73