SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'GD9'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1M4I_A_KANA500_1
(AMINOGLYCOSIDE
2'-N-ACETYLTRANSFERA
SE)		 2y3a PHOSPHATIDYLINOSITOL
-4,5-BISPHOSPHATE
3-KINASE CATALYTIC
SUBUNIT BETA ISOFORM
(Mus
musculus) 		4 / 8 ASP A 913
ASP A 807
THR A 810
ASP A 931
 None
GD9  A2058 (-3.7A)
None
GD9  A2058 (-3.2A)
 0.80A 1m4iA-2y3aA:
undetectable		 1m4iA-2y3aA:
10.21
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4XE0_A_40LA1101_0
(PHOSPHATIDYLINOSITOL
4,5-BISPHOSPHATE
3-KINASE CATALYTIC
SUBUNIT DELTA
ISOFORM)		 2y3a PHOSPHATIDYLINOSITOL
-4,5-BISPHOSPHATE
3-KINASE CATALYTIC
SUBUNIT BETA ISOFORM
(Mus
musculus) 		5 / 12 ILE A 845
VAL A 848
THR A 853
MET A 920
ILE A 930
 GD9  A2058 (-3.8A)
GD9  A2058 (-3.8A)
GD9  A2058 ( 4.8A)
GD9  A2058 (-3.6A)
GD9  A2058 (-4.2A)
 1.01A 4xe0A-2y3aA:
38.7		 4xe0A-2y3aA:
51.44
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4XE0_A_40LA1101_0
(PHOSPHATIDYLINOSITOL
4,5-BISPHOSPHATE
3-KINASE CATALYTIC
SUBUNIT DELTA
ISOFORM)		 2y3a PHOSPHATIDYLINOSITOL
-4,5-BISPHOSPHATE
3-KINASE CATALYTIC
SUBUNIT BETA ISOFORM
(Mus
musculus) 		6 / 12 MET A 773
PRO A 779
TYR A 833
ASP A 856
MET A 920
ILE A 930
 GD9  A2058 (-4.3A)
None
GD9  A2058 (-3.8A)
GD9  A2058 ( 4.6A)
GD9  A2058 (-3.6A)
GD9  A2058 (-4.2A)
 1.46A 4xe0A-2y3aA:
38.7		 4xe0A-2y3aA:
51.44
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4XE0_A_40LA1101_0
(PHOSPHATIDYLINOSITOL
4,5-BISPHOSPHATE
3-KINASE CATALYTIC
SUBUNIT DELTA
ISOFORM)		 2y3a PHOSPHATIDYLINOSITOL
-4,5-BISPHOSPHATE
3-KINASE CATALYTIC
SUBUNIT BETA ISOFORM
(Mus
musculus) 		6 / 12 MET A 773
PRO A 779
TYR A 833
VAL A 848
MET A 920
ILE A 930
 GD9  A2058 (-4.3A)
None
GD9  A2058 (-3.8A)
GD9  A2058 (-3.8A)
GD9  A2058 (-3.6A)
GD9  A2058 (-4.2A)
 0.99A 4xe0A-2y3aA:
38.7		 4xe0A-2y3aA:
51.44
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4XE0_A_40LA1101_0
(PHOSPHATIDYLINOSITOL
4,5-BISPHOSPHATE
3-KINASE CATALYTIC
SUBUNIT DELTA
ISOFORM)		 2y3a PHOSPHATIDYLINOSITOL
-4,5-BISPHOSPHATE
3-KINASE CATALYTIC
SUBUNIT BETA ISOFORM
(Mus
musculus) 		7 / 12 PRO A 779
ILE A 797
TYR A 833
ASP A 856
THR A 853
MET A 920
ILE A 930
 None
None
GD9  A2058 (-3.8A)
GD9  A2058 ( 4.6A)
GD9  A2058 ( 4.8A)
GD9  A2058 (-3.6A)
GD9  A2058 (-4.2A)
 1.25A 4xe0A-2y3aA:
38.7		 4xe0A-2y3aA:
51.44
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4XE0_A_40LA1101_0
(PHOSPHATIDYLINOSITOL
4,5-BISPHOSPHATE
3-KINASE CATALYTIC
SUBUNIT DELTA
ISOFORM)		 2y3a PHOSPHATIDYLINOSITOL
-4,5-BISPHOSPHATE
3-KINASE CATALYTIC
SUBUNIT BETA ISOFORM
(Mus
musculus) 		7 / 12 PRO A 779
ILE A 797
TYR A 833
VAL A 848
THR A 853
MET A 920
ILE A 930
 None
None
GD9  A2058 (-3.8A)
GD9  A2058 (-3.8A)
GD9  A2058 ( 4.8A)
GD9  A2058 (-3.6A)
GD9  A2058 (-4.2A)
 0.66A 4xe0A-2y3aA:
38.7		 4xe0A-2y3aA:
51.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NWW_A_ACAA18_2
(SCRFP-TAG,GP41)		 2y3a PHOSPHATIDYLINOSITOL
-4,5-BISPHOSPHATE
3-KINASE CATALYTIC
SUBUNIT BETA ISOFORM
(Mus
musculus) 		3 / 3 LYS A 922
TRP A 878
SER A 851
 None
None
GD9  A2058 ( 4.5A)
 1.23A 5nwwA-2y3aA:
undetectable		 5nwwA-2y3aA:
3.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZV2_A_LEVA801_2
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)		 2y3a PHOSPHATIDYLINOSITOL
-4,5-BISPHOSPHATE
3-KINASE CATALYTIC
SUBUNIT BETA ISOFORM
(Mus
musculus) 		3 / 3 LYS A 776
LEU A 804
ASP A 931
 None
None
GD9  A2058 (-3.2A)
 0.89A 5zv2A-2y3aA:
2.4		 5zv2A-2y3aA:
5.90