SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'GD3'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JR1_B_MOAB1333_1
(INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE 2)		 2yzw ADP-RIBOSYLGLYCOHYDR
OLASE
(Thermus
thermophilus) 		4 / 8 ASP A  58
ASN A 128
GLY A 217
GLY A  25
 GD3  A 502 (-3.1A)
None
None
None
 0.80A 1jr1B-2yzwA:
undetectable		 1jr1B-2yzwA:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DTJ_A_THRA401_0
(ASPARTOKINASE)		 2yzw ADP-RIBOSYLGLYCOHYDR
OLASE
(Thermus
thermophilus) 		4 / 8 ASP A 251
GLY A 223
ALA A 227
ASN A 128
 GD3  A 501 (-2.7A)
None
None
None
 0.82A 2dtjA-2yzwA:
undetectable
2dtjB-2yzwA:
undetectable		 2dtjA-2yzwA:
21.75
2dtjB-2yzwA:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N2O_C_AG2C1002_1
(BIOSYNTHETIC
ARGININE
DECARBOXYLASE)		 2yzw ADP-RIBOSYLGLYCOHYDR
OLASE
(Thermus
thermophilus) 		4 / 8 SER A  60
LEU A  50
ASP A  22
ASP A 253
 None
None
GD3  A 502 ( 4.9A)
GD3  A 501 ( 2.8A)
 1.19A 3n2oC-2yzwA:
undetectable
3n2oD-2yzwA:
undetectable		 3n2oC-2yzwA:
19.25
3n2oD-2yzwA:
19.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4I41_A_MIXA501_1
(SERINE/THREONINE-PRO
TEIN KINASE PIM-1)		 3q4i PHOSPHOHYDROLASE
(MUTT/NUDIX FAMILY
PROTEIN)
(Bacillus
cereus) 		5 / 12 ILE A 129
VAL A 108
ASP A  70
ILE A  71
GLU A 116
 None
None
None
None
GD3  A 301 (-3.1A)
 1.41A 4i41A-3q4iA:
undetectable		 4i41A-3q4iA:
19.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BS8_G_MFXG101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
TTACGTGCATAGTCATTCAT
GACC)		 2yzw ADP-RIBOSYLGLYCOHYDR
OLASE
(Thermus
thermophilus) 		4 / 7 ALA A 263
ASP A  58
GLY A  25
GLU A  29
 None
GD3  A 502 (-3.1A)
None
GD3  A 501 (-3.0A)
 0.84A 5bs8A-2yzwA:
undetectable
5bs8C-2yzwA:
undetectable
5bs8D-2yzwA:
undetectable		 5bs8A-2yzwA:
19.88
5bs8C-2yzwA:
19.88
5bs8D-2yzwA:
22.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BTG_F_LFXF101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
TTACGTGCATAGTCATTCAT
GACC)		 2yzw ADP-RIBOSYLGLYCOHYDR
OLASE
(Thermus
thermophilus) 		4 / 7 ALA A 263
ASP A  58
GLY A  25
GLU A  29
 None
GD3  A 502 (-3.1A)
None
GD3  A 501 (-3.0A)
 0.85A 5btgA-2yzwA:
undetectable
5btgC-2yzwA:
undetectable
5btgD-2yzwA:
undetectable		 5btgA-2yzwA:
19.88
5btgC-2yzwA:
19.88
5btgD-2yzwA:
22.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BW4_B_SAMB301_1
(16S RRNA
(ADENINE(1408)-N(1))
-METHYLTRANSFERASE)		 3q4i PHOSPHOHYDROLASE
(MUTT/NUDIX FAMILY
PROTEIN)
(Bacillus
cereus) 		3 / 3 ASP A  70
GLU A 116
SER A 140
 None
GD3  A 301 (-3.1A)
None
 0.86A 5bw4B-3q4iA:
undetectable		 5bw4B-3q4iA:
18.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6G31_D_ZOLD401_0
(GERANYLGERANYL
PYROPHOSPHATE
SYNTHASE)		 3txm 26S PROTEASOME
REGULATORY COMPLEX
SUBUNIT P42B
(Drosophila
melanogaster) 		4 / 7 LEU A 270
ASP A 266
ASP A 265
GLN A 263
 None
GD3  A   1 (-2.1A)
GD3  A   1 (-3.9A)
GD3  A   1 ( 4.8A)
 1.37A 6g31D-3txmA:
2.1		 6g31D-3txmA:
12.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6G31_J_ZOLJ401_0
(GERANYLGERANYL
PYROPHOSPHATE
SYNTHASE)		 3txm 26S PROTEASOME
REGULATORY COMPLEX
SUBUNIT P42B
(Drosophila
melanogaster) 		4 / 6 LEU A 270
ASP A 266
ASP A 265
GLN A 263
 None
GD3  A   1 (-2.1A)
GD3  A   1 (-3.9A)
GD3  A   1 ( 4.8A)
 1.28A 6g31J-3txmA:
3.4		 6g31J-3txmA:
12.69