SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'GCU'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AKD_A_CAMA420_0
(CYTOCHROME P450CAM)		 4n91 TRAP DICARBOXYLATE
TRANSPORTER, DCTP
SUBUNIT
(Anaerococcus
prevotii) 		5 / 11 THR A 147
GLY A  48
VAL A  93
ASP A 242
VAL A 244
 None
None
None
GCU  A 401 ( 2.7A)
None
 0.96A 1akdA-4n91A:
undetectable		 1akdA-4n91A:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KF6_N_ACTN803_0
(FUMARATE REDUCTASE
FLAVOPROTEIN
FUMARATE REDUCTASE
IRON-SULFUR PROTEIN)		 1mqq ALPHA-D-GLUCURONIDAS
E
(Geobacillus
stearothermophil
us) 		4 / 6 ARG A 159
GLY A 525
TYR A 535
TRP A 540
 GCU  A 701 (-3.4A)
None
GOL  A 753 (-4.3A)
GOL  A 753 (-3.9A)
 1.44A 1kf6M-1mqqA:
0.0
1kf6N-1mqqA:
0.0		 1kf6M-1mqqA:
21.33
1kf6N-1mqqA:
16.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LIN_A_TFPA155_1
(CALMODULIN)		 4n91 TRAP DICARBOXYLATE
TRANSPORTER, DCTP
SUBUNIT
(Anaerococcus
prevotii) 		4 / 7 GLN A 177
GLU A 214
PHE A 295
ALA A 151
 GCU  A 401 ( 3.4A)
None
None
GCU  A 401 (-3.6A)
 1.32A 1linA-4n91A:
undetectable		 1linA-4n91A:
16.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PHG_A_MYTA422_1
(CYTOCHROME P450-CAM)		 4n91 TRAP DICARBOXYLATE
TRANSPORTER, DCTP
SUBUNIT
(Anaerococcus
prevotii) 		5 / 11 THR A 147
GLY A  48
VAL A  93
ASP A 242
VAL A 244
 None
None
None
GCU  A 401 ( 2.7A)
None
 0.95A 1phgA-4n91A:
undetectable		 1phgA-4n91A:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A1N_A_CAMA1422_0
(CYTOCHROME P450-CAM)		 4n91 TRAP DICARBOXYLATE
TRANSPORTER, DCTP
SUBUNIT
(Anaerococcus
prevotii) 		5 / 11 THR A 147
GLY A  48
VAL A  93
ASP A 242
VAL A 244
 None
None
None
GCU  A 401 ( 2.7A)
None
 0.92A 2a1nA-4n91A:
undetectable		 2a1nA-4n91A:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CP4_A_CAMA416_0
(CYTOCHROME P450-CAM)		 4n91 TRAP DICARBOXYLATE
TRANSPORTER, DCTP
SUBUNIT
(Anaerococcus
prevotii) 		5 / 10 THR A 147
GLY A  48
VAL A  93
ASP A 242
VAL A 244
 None
None
None
GCU  A 401 ( 2.7A)
None
 0.95A 2cp4A-4n91A:
undetectable		 2cp4A-4n91A:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2TSR_B_D16B409_1
(THYMIDYLATE SYNTHASE)		 1mqq ALPHA-D-GLUCURONIDAS
E
(Geobacillus
stearothermophil
us) 		4 / 8 ARG A 318
ILE A 316
LEU A 308
GLY A 313
 GCU  A 701 (-2.8A)
None
None
None
 0.92A 2tsrB-1mqqA:
undetectable		 2tsrB-1mqqA:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Z0A_D_GLYD73_0
(NONSTRUCTURAL
PROTEIN 1)		 1cb8 PROTEIN
(CHONDROITINASE AC)
(Pedobacter
heparinus) 		4 / 4 ARG A 421
ASP A 407
SER A 414
ARG A 415
 GCU  A2002 (-2.7A)
CA  A3000 ( 2.2A)
None
GCU  A2002 (-2.8A)
 1.35A 2z0aC-1cb8A:
2.8
2z0aD-1cb8A:
2.8		 2z0aC-1cb8A:
9.69
2z0aD-1cb8A:
9.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3APW_A_DP0A190_1
(ALPHA-1-ACID
GLYCOPROTEIN 2)		 4n91 TRAP DICARBOXYLATE
TRANSPORTER, DCTP
SUBUNIT
(Anaerococcus
prevotii) 		5 / 12 TYR A 157
PHE A 198
VAL A 201
ALA A 151
SER A 219
 None
BDP  A 402 ( 3.6A)
None
GCU  A 401 (-3.6A)
GCU  A 401 ( 4.6A)
 1.47A 3apwA-4n91A:
undetectable		 3apwA-4n91A:
19.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FPJ_A_SAMA301_1
(PUTATIVE
UNCHARACTERIZED
PROTEIN)		 1mqq ALPHA-D-GLUCURONIDAS
E
(Geobacillus
stearothermophil
us) 		4 / 6 GLY A 160
THR A 453
GLU A 158
GLU A 386
 None
None
GCU  A 701 (-3.5A)
None
 0.98A 3fpjA-1mqqA:
undetectable		 3fpjA-1mqqA:
18.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K13_A_THHA642_0
(5-METHYLTETRAHYDROFO
LATE-HOMOCYSTEINE
METHYLTRANSFERASE)		 2w87 ESTERASE D
(Cellvibrio
japonicus) 		5 / 12 GLU A 126
ASN A  43
GLY A 127
GLY A  71
ASN A  69
 None
GCU  A1150 ( 2.9A)
None
None
None
 1.19A 3k13A-2w87A:
undetectable		 3k13A-2w87A:
18.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K13_B_THHB643_0
(5-METHYLTETRAHYDROFO
LATE-HOMOCYSTEINE
METHYLTRANSFERASE)		 2w87 ESTERASE D
(Cellvibrio
japonicus) 		5 / 12 GLU A 126
ASN A  43
GLY A 127
GLY A  71
ASN A  69
 None
GCU  A1150 ( 2.9A)
None
None
None
 1.18A 3k13B-2w87A:
undetectable		 3k13B-2w87A:
18.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K13_C_THHC643_0
(5-METHYLTETRAHYDROFO
LATE-HOMOCYSTEINE
METHYLTRANSFERASE)		 2w87 ESTERASE D
(Cellvibrio
japonicus) 		5 / 12 GLU A 126
ASN A  43
GLY A 127
GLY A  71
ASN A  69
 None
GCU  A1150 ( 2.9A)
None
None
None
 1.20A 3k13C-2w87A:
undetectable		 3k13C-2w87A:
18.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LXI_B_CAMB423_0
(CYTOCHROME P450)		 4n91 TRAP DICARBOXYLATE
TRANSPORTER, DCTP
SUBUNIT
(Anaerococcus
prevotii) 		5 / 11 THR A 147
GLY A  48
VAL A  93
ASP A 242
VAL A 244
 None
None
None
GCU  A 401 ( 2.7A)
None
 0.79A 3lxiB-4n91A:
undetectable		 3lxiB-4n91A:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MSS_B_STIB1_2
(TYROSINE-PROTEIN
KINASE ABL1)		 4n91 TRAP DICARBOXYLATE
TRANSPORTER, DCTP
SUBUNIT
(Anaerococcus
prevotii) 		4 / 7 TYR A 325
VAL A 124
ILE A 134
ARG A 154
 None
None
None
GCU  A 401 ( 2.7A)
 1.08A 3mssB-4n91A:
undetectable		 3mssB-4n91A:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C49_C_HCYC1384_1
(CORTICOSTEROID-BINDI
NG GLOBULIN)		 1mqq ALPHA-D-GLUCURONIDAS
E
(Geobacillus
stearothermophil
us) 		5 / 12 SER A 444
VAL A 443
PHE A 320
PHE A 365
HIS A 527
 None
None
GCU  A 701 (-3.8A)
None
GOL  A 753 (-4.0A)
 1.45A 4c49C-1mqqA:
undetectable		 4c49C-1mqqA:
19.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C9L_A_CAMA1419_0
(CYTOCHROME P450)		 4n91 TRAP DICARBOXYLATE
TRANSPORTER, DCTP
SUBUNIT
(Anaerococcus
prevotii) 		5 / 12 THR A 147
GLY A  48
VAL A  93
ASP A 242
VAL A 244
 None
None
None
GCU  A 401 ( 2.7A)
None
 0.90A 4c9lA-4n91A:
undetectable		 4c9lA-4n91A:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C9L_B_CAMB1419_0
(CYTOCHROME P450)		 4n91 TRAP DICARBOXYLATE
TRANSPORTER, DCTP
SUBUNIT
(Anaerococcus
prevotii) 		5 / 12 THR A 147
GLY A  48
VAL A  93
ASP A 242
VAL A 244
 None
None
None
GCU  A 401 ( 2.7A)
None
 0.86A 4c9lB-4n91A:
undetectable		 4c9lB-4n91A:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C9N_B_CAMB1420_0
(CYTOCHROME P450)		 4n91 TRAP DICARBOXYLATE
TRANSPORTER, DCTP
SUBUNIT
(Anaerococcus
prevotii) 		5 / 10 THR A 147
GLY A  48
VAL A  93
ASP A 242
VAL A 244
 None
None
None
GCU  A 401 ( 2.7A)
None
 0.87A 4c9nB-4n91A:
undetectable		 4c9nB-4n91A:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C9O_A_CAMA423_0
(CYTOCHROME P450)		 4n91 TRAP DICARBOXYLATE
TRANSPORTER, DCTP
SUBUNIT
(Anaerococcus
prevotii) 		5 / 12 THR A 147
GLY A  48
VAL A  93
ASP A 242
VAL A 244
 None
None
None
GCU  A 401 ( 2.7A)
None
 0.90A 4c9oA-4n91A:
undetectable		 4c9oA-4n91A:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C9O_B_CAMB423_0
(CYTOCHROME P450)		 4n91 TRAP DICARBOXYLATE
TRANSPORTER, DCTP
SUBUNIT
(Anaerococcus
prevotii) 		5 / 12 THR A 147
GLY A  48
VAL A  93
ASP A 242
VAL A 244
 None
None
None
GCU  A 401 ( 2.7A)
None
 0.90A 4c9oB-4n91A:
undetectable		 4c9oB-4n91A:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C9P_B_CAMB423_0
(CYTOCHROME P450)		 4n91 TRAP DICARBOXYLATE
TRANSPORTER, DCTP
SUBUNIT
(Anaerococcus
prevotii) 		5 / 10 THR A 147
GLY A  48
VAL A  93
ASP A 242
VAL A 244
 None
None
None
GCU  A 401 ( 2.7A)
None
 0.83A 4c9pB-4n91A:
undetectable		 4c9pB-4n91A:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CP4_A_CAMA416_0
(CYTOCHROME P450-CAM)		 4n91 TRAP DICARBOXYLATE
TRANSPORTER, DCTP
SUBUNIT
(Anaerococcus
prevotii) 		4 / 7 THR A 147
VAL A  93
ASP A 242
VAL A 244
 None
None
GCU  A 401 ( 2.7A)
None
 0.80A 4cp4A-4n91A:
undetectable		 4cp4A-4n91A:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N49_A_SAMA601_1
(CAP-SPECIFIC MRNA
(NUCLEOSIDE-2'-O-)-M
ETHYLTRANSFERASE 1)		 1mqq ALPHA-D-GLUCURONIDAS
E
(Geobacillus
stearothermophil
us) 		4 / 4 ASN A 360
GLY A 361
ASP A 283
ASP A 364
 None
None
None
GCU  A 701 ( 2.3A)
 1.35A 4n49A-1mqqA:
undetectable		 4n49A-1mqqA:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ADE_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 1mqq ALPHA-D-GLUCURONIDAS
E
(Geobacillus
stearothermophil
us) 		4 / 6 VAL A 443
VAL A 200
TRP A 150
PHE A 320
 None
None
GCU  A 701 (-4.7A)
GCU  A 701 (-3.8A)
 1.49A 5adeA-1mqqA:
0.0
5adeB-1mqqA:
0.0		 5adeA-1mqqA:
22.03
5adeB-1mqqA:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X7P_A_ACRA1431_1
(GLYCOSIDE HYDROLASE
FAMILY 31
ALPHA-GLUCOSIDASE)		 2w87 ESTERASE D
(Cellvibrio
japonicus) 		4 / 7 ASN A  29
HIS A  30
TRP A  99
ASN A 130
 GCU  A1150 ( 4.7A)
GCU  A1150 (-4.0A)
GCU  A1150 (-3.9A)
GCU  A1150 (-3.1A)
 0.21A 5x7pA-2w87A:
6.7		 5x7pA-2w87A:
7.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FGD_A_ACTA820_0
(GEPHYRIN)		 4n91 TRAP DICARBOXYLATE
TRANSPORTER, DCTP
SUBUNIT
(Anaerococcus
prevotii) 		4 / 5 PRO A  44
THR A  45
GLN A  39
MET A 218
 None
None
GCU  A 401 ( 3.7A)
None
 1.02A 6fgdA-4n91A:
undetectable		 6fgdA-4n91A:
20.47