SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'GCS'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1R15_C_NCAC339_0
(ADP-RIBOSYL CYCLASE)		 5gsm EXO-BETA-D-GLUCOSAMI
NIDASE
(Thermococcus
kodakarensis) 		3 / 3 GLU A 103
ASN A 394
TRP A 398
 GCS  A 801 (-2.9A)
None
None
 1.24A 1r15C-5gsmA:
2.2		 1r15C-5gsmA:
15.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1R15_D_NCAD349_0
(ADP-RIBOSYL CYCLASE)		 5gsm EXO-BETA-D-GLUCOSAMI
NIDASE
(Thermococcus
kodakarensis) 		3 / 3 GLU A 103
ASN A 394
TRP A 398
 GCS  A 801 (-2.9A)
None
None
 1.22A 1r15D-5gsmA:
2.4		 1r15D-5gsmA:
15.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1R15_E_NCAE359_0
(ADP-RIBOSYL CYCLASE)		 5gsm EXO-BETA-D-GLUCOSAMI
NIDASE
(Thermococcus
kodakarensis) 		3 / 3 GLU A 103
ASN A 394
TRP A 398
 GCS  A 801 (-2.9A)
None
None
 1.23A 1r15E-5gsmA:
2.4		 1r15E-5gsmA:
15.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1R15_F_NCAF369_0
(ADP-RIBOSYL CYCLASE)		 5gsm EXO-BETA-D-GLUCOSAMI
NIDASE
(Thermococcus
kodakarensis) 		3 / 3 GLU A 103
ASN A 394
TRP A 398
 GCS  A 801 (-2.9A)
None
None
 1.24A 1r15F-5gsmA:
2.5		 1r15F-5gsmA:
15.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V55_P_CHDP4525_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE I
CYTOCHROME C OXIDASE
POLYPEPTIDE III)		 5gsm EXO-BETA-D-GLUCOSAMI
NIDASE
(Thermococcus
kodakarensis) 		4 / 7 LEU A 380
HIS A  59
THR A  52
TYR A  53
 None
None
None
GCS  A 801 (-4.8A)
 1.19A 1v55C-5gsmA:
undetectable
1v55N-5gsmA:
undetectable
1v55P-5gsmA:
undetectable		 1v55C-5gsmA:
16.50
1v55N-5gsmA:
21.26
1v55P-5gsmA:
16.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X0P_A_ADNA1607_1
(ALCALIGIN
BIOSYNTHESIS PROTEIN)		 4qwp CHITOSANASE
(Pseudomonas
sp.
A-01) 		4 / 8 GLY A 154
HIS A 153
ILE A  52
HIS A 203
 GCS  A 301 (-3.3A)
None
None
GCS  A 303 ( 4.9A)
 0.94A 2x0pA-4qwpA:
undetectable		 2x0pA-4qwpA:
18.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ABM_C_CHDC525_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 5gsm EXO-BETA-D-GLUCOSAMI
NIDASE
(Thermococcus
kodakarensis) 		4 / 8 HIS A  59
THR A  52
TYR A  53
LEU A 380
 None
None
GCS  A 801 (-4.8A)
None
 1.19A 3abmA-5gsmA:
undetectable
3abmC-5gsmA:
undetectable
3abmP-5gsmA:
undetectable		 3abmA-5gsmA:
21.26
3abmC-5gsmA:
16.50
3abmP-5gsmA:
16.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ASN_P_CHDP1525_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 5gsm EXO-BETA-D-GLUCOSAMI
NIDASE
(Thermococcus
kodakarensis) 		4 / 8 LEU A 380
HIS A  59
THR A  52
TYR A  53
 None
None
None
GCS  A 801 (-4.8A)
 1.21A 3asnC-5gsmA:
undetectable
3asnN-5gsmA:
undetectable
3asnP-5gsmA:
undetectable		 3asnC-5gsmA:
16.50
3asnN-5gsmA:
21.26
3asnP-5gsmA:
16.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ASO_C_CHDC525_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 5gsm EXO-BETA-D-GLUCOSAMI
NIDASE
(Thermococcus
kodakarensis) 		4 / 8 HIS A  59
THR A  52
TYR A  53
LEU A 380
 None
None
GCS  A 801 (-4.8A)
None
 1.19A 3asoA-5gsmA:
undetectable
3asoC-5gsmA:
undetectable
3asoP-5gsmA:
undetectable		 3asoA-5gsmA:
21.26
3asoC-5gsmA:
16.50
3asoP-5gsmA:
16.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DZG_A_NCAA302_0
(ADP-RIBOSYL CYCLASE
1)		 5gsm EXO-BETA-D-GLUCOSAMI
NIDASE
(Thermococcus
kodakarensis) 		4 / 7 LEU A 352
GLU A 103
TRP A 398
SER A 351
 GCS  A 801 (-4.9A)
GCS  A 801 (-2.9A)
None
None
 1.13A 3dzgA-5gsmA:
undetectable		 3dzgA-5gsmA:
16.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DZG_B_NCAB302_0
(ADP-RIBOSYL CYCLASE
1)		 5gsm EXO-BETA-D-GLUCOSAMI
NIDASE
(Thermococcus
kodakarensis) 		4 / 7 LEU A 352
GLU A 103
TRP A 398
SER A 351
 GCS  A 801 (-4.9A)
GCS  A 801 (-2.9A)
None
None
 1.11A 3dzgB-5gsmA:
2.2		 3dzgB-5gsmA:
16.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3I9J_B_NCAB302_0
(ADP-RIBOSYL CYCLASE)		 5gsm EXO-BETA-D-GLUCOSAMI
NIDASE
(Thermococcus
kodakarensis) 		4 / 6 LEU A 352
GLU A 103
TRP A 398
SER A 351
 GCS  A 801 (-4.9A)
GCS  A 801 (-2.9A)
None
None
 1.22A 3i9jB-5gsmA:
2.1		 3i9jB-5gsmA:
15.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K8M_A_ACRA720_1
(ALPHA-AMYLASE, SUSG)		 5gsm EXO-BETA-D-GLUCOSAMI
NIDASE
(Thermococcus
kodakarensis) 		4 / 7 TRP A 398
LEU A 352
TRP A 308
ASN A 394
 None
GCS  A 801 (-4.9A)
GCS  A 801 ( 3.9A)
None
 1.38A 3k8mA-5gsmA:
12.7		 3k8mA-5gsmA:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K8M_B_ACRB820_1
(ALPHA-AMYLASE, SUSG)		 5gsm EXO-BETA-D-GLUCOSAMI
NIDASE
(Thermococcus
kodakarensis) 		4 / 7 TRP A 398
LEU A 352
TRP A 308
ASN A 394
 None
GCS  A 801 (-4.9A)
GCS  A 801 ( 3.9A)
None
 1.37A 3k8mB-5gsmA:
12.3		 3k8mB-5gsmA:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ROP_A_NCAA302_0
(ADP-RIBOSYL CYCLASE
1)		 5gsm EXO-BETA-D-GLUCOSAMI
NIDASE
(Thermococcus
kodakarensis) 		4 / 6 LEU A 352
GLU A 103
TRP A 398
SER A 351
 GCS  A 801 (-4.9A)
GCS  A 801 (-2.9A)
None
None
 1.07A 3ropA-5gsmA:
2.5		 3ropA-5gsmA:
15.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WG7_C_CHDC306_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 5gsm EXO-BETA-D-GLUCOSAMI
NIDASE
(Thermococcus
kodakarensis) 		4 / 8 HIS A  59
THR A  52
TYR A  53
LEU A 380
 None
None
GCS  A 801 (-4.8A)
None
 1.20A 3wg7A-5gsmA:
undetectable
3wg7C-5gsmA:
undetectable
3wg7P-5gsmA:
undetectable		 3wg7A-5gsmA:
21.26
3wg7C-5gsmA:
16.50
3wg7P-5gsmA:
16.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3X2Q_C_CHDC305_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 5gsm EXO-BETA-D-GLUCOSAMI
NIDASE
(Thermococcus
kodakarensis) 		4 / 8 HIS A  59
THR A  52
TYR A  53
LEU A 380
 None
None
GCS  A 801 (-4.8A)
None
 1.19A 3x2qA-5gsmA:
undetectable
3x2qC-5gsmA:
undetectable
3x2qP-5gsmA:
undetectable		 3x2qA-5gsmA:
21.26
3x2qC-5gsmA:
16.50
3x2qP-5gsmA:
16.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4OLT_A_GCSA302_1
(CHITOSANASE)		 4qwp CHITOSANASE
(Pseudomonas
sp.
A-01) 		5 / 5 ARG A  45
THR A  55
THR A  58
ASP A  60
TYR A 125
 GCS  A 302 (-4.0A)
GCS  A 302 ( 4.2A)
GCS  A 302 ( 3.4A)
GCS  A 302 (-3.0A)
None
 0.14A 4oltA-4qwpA:
41.9		 4oltA-4qwpA:
99.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OLT_A_GCSA303_1
(CHITOSANASE)		 1qgi PROTEIN
(CHITOSANASE)
(Bacillus
circulans) 		4 / 6 ILE A  53
ASP A  55
ARG A  57
GLY A  65
 NAG  A 602 ( 4.7A)
None
GCS  A 600 (-3.7A)
GCS  A 601 ( 4.6A)
 0.50A 4oltA-1qgiA:
21.0		 4oltA-1qgiA:
27.68
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4OLT_A_GCSA303_1
(CHITOSANASE)		 4qwp CHITOSANASE
(Pseudomonas
sp.
A-01) 		5 / 6 ILE A  41
ARG A  45
GLY A  53
VAL A 151
HIS A 203
 GCS  A 303 (-4.2A)
GCS  A 302 (-4.0A)
None
None
GCS  A 303 ( 4.9A)
 0.21A 4oltA-4qwpA:
41.9		 4oltA-4qwpA:
99.60
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4OLT_A_GCSA304_1
(CHITOSANASE)		 4qwp CHITOSANASE
(Pseudomonas
sp.
A-01) 		4 / 4 TYR A  37
ILE A  41
THR A  48
TYR A 233
 GCS  A 303 (-4.7A)
GCS  A 303 (-4.2A)
GCS  A 303 ( 4.2A)
GCS  A 304 (-3.5A)
 0.09A 4oltA-4qwpA:
41.9		 4oltA-4qwpA:
99.60
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4OLT_B_GCSB302_1
(CHITOSANASE)		 4qwp CHITOSANASE
(Pseudomonas
sp.
A-01) 		5 / 5 ARG A  45
THR A  55
THR A  58
ASP A  60
TYR A 125
 GCS  A 302 (-4.0A)
GCS  A 302 ( 4.2A)
GCS  A 302 ( 3.4A)
GCS  A 302 (-3.0A)
None
 0.11A 4oltB-4qwpA:
42.7		 4oltB-4qwpA:
99.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OLT_B_GCSB303_1
(CHITOSANASE)		 1qgi PROTEIN
(CHITOSANASE)
(Bacillus
circulans) 		4 / 6 ILE A  53
ASP A  55
ARG A  57
GLY A  65
 NAG  A 602 ( 4.7A)
None
GCS  A 600 (-3.7A)
GCS  A 601 ( 4.6A)
 0.55A 4oltB-1qgiA:
20.9		 4oltB-1qgiA:
27.68
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4OLT_B_GCSB303_1
(CHITOSANASE)		 4qwp CHITOSANASE
(Pseudomonas
sp.
A-01) 		5 / 6 ILE A  41
ARG A  45
GLY A  53
VAL A 151
HIS A 203
 GCS  A 303 (-4.2A)
GCS  A 302 (-4.0A)
None
None
GCS  A 303 ( 4.9A)
 0.15A 4oltB-4qwpA:
42.7		 4oltB-4qwpA:
99.60
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4OLT_B_GCSB304_1
(CHITOSANASE)		 4qwp CHITOSANASE
(Pseudomonas
sp.
A-01) 		5 / 5 TYR A  37
ILE A  41
THR A  48
HIS A 203
TYR A 233
 GCS  A 303 (-4.7A)
GCS  A 303 (-4.2A)
GCS  A 303 ( 4.2A)
GCS  A 303 ( 4.9A)
GCS  A 304 (-3.5A)
 0.13A 4oltB-4qwpA:
42.7		 4oltB-4qwpA:
99.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QWP_B_GCSB307_1
(CHITOSANASE)		 1qgi PROTEIN
(CHITOSANASE)
(Bacillus
circulans) 		4 / 7 ARG A  57
THR A  60
GLY A  65
THR A  67
 GCS  A 600 (-3.7A)
GCS  A 601 ( 4.1A)
GCS  A 601 ( 4.6A)
None
 0.46A 4qwpB-1qgiA:
21.1		 4qwpB-1qgiA:
27.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B1A_C_CHDC305_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 5gsm EXO-BETA-D-GLUCOSAMI
NIDASE
(Thermococcus
kodakarensis) 		4 / 8 HIS A  59
THR A  52
TYR A  53
LEU A 380
 None
None
GCS  A 801 (-4.8A)
None
 1.18A 5b1aA-5gsmA:
undetectable
5b1aC-5gsmA:
undetectable
5b1aP-5gsmA:
undetectable		 5b1aA-5gsmA:
21.26
5b1aC-5gsmA:
16.50
5b1aP-5gsmA:
16.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B3S_C_CHDC301_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 5gsm EXO-BETA-D-GLUCOSAMI
NIDASE
(Thermococcus
kodakarensis) 		4 / 8 HIS A  59
THR A  52
TYR A  53
LEU A 380
 None
None
GCS  A 801 (-4.8A)
None
 1.19A 5b3sA-5gsmA:
undetectable
5b3sC-5gsmA:
undetectable
5b3sP-5gsmA:
undetectable		 5b3sA-5gsmA:
21.26
5b3sC-5gsmA:
16.50
5b3sP-5gsmA:
16.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5HWA_A_GCSA301_1
(CHITOSANASE)		 1qgi PROTEIN
(CHITOSANASE)
(Bacillus
circulans) 		5 / 8 ILE A  53
ASP A  55
ARG A  57
GLY A  65
THR A  67
 NAG  A 602 ( 4.7A)
None
GCS  A 600 (-3.7A)
GCS  A 601 ( 4.6A)
None
 0.52A 5hwaA-1qgiA:
39.1		 5hwaA-1qgiA:
99.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HWA_A_GCSA301_1
(CHITOSANASE)		 4qwp CHITOSANASE
(Pseudomonas
sp.
A-01) 		4 / 8 ILE A  41
ARG A  45
GLY A  53
THR A  55
 GCS  A 303 (-4.2A)
GCS  A 302 (-4.0A)
None
GCS  A 302 ( 4.2A)
 0.20A 5hwaA-4qwpA:
10.7		 5hwaA-4qwpA:
26.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HWA_A_GCSA302_1
(CHITOSANASE)		 4qwp CHITOSANASE
(Pseudomonas
sp.
A-01) 		5 / 7 ARG A  45
THR A  55
ASP A  60
TYR A 125
GLY A 154
 GCS  A 302 (-4.0A)
GCS  A 302 ( 4.2A)
GCS  A 302 (-3.0A)
None
GCS  A 301 (-3.3A)
 0.38A 5hwaA-4qwpA:
16.9		 5hwaA-4qwpA:
26.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HWA_A_GCSA302_1
(CHITOSANASE)		 4qwp CHITOSANASE
(Pseudomonas
sp.
A-01) 		5 / 7 ARG A  45
THR A  58
ASP A  60
TYR A 125
GLY A 154
 GCS  A 302 (-4.0A)
GCS  A 302 ( 3.4A)
GCS  A 302 (-3.0A)
None
GCS  A 301 (-3.3A)
 1.40A 5hwaA-4qwpA:
16.9		 5hwaA-4qwpA:
26.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M45_A_ACTA803_0
(ACETONE CARBOXYLASE
ALPHA SUBUNIT)		 5gsm EXO-BETA-D-GLUCOSAMI
NIDASE
(Thermococcus
kodakarensis) 		4 / 4 GLU A 179
PRO A 280
ILE A 277
LEU A 278
 GCS  A 801 (-2.3A)
None
None
None
 1.17A 5m45A-5gsmA:
undetectable		 5m45A-5gsmA:
23.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M45_D_ACTD803_0
(ACETONE CARBOXYLASE
ALPHA SUBUNIT)		 5gsm EXO-BETA-D-GLUCOSAMI
NIDASE
(Thermococcus
kodakarensis) 		4 / 4 GLU A 179
PRO A 280
ILE A 277
LEU A 278
 GCS  A 801 (-2.3A)
None
None
None
 1.19A 5m45D-5gsmA:
undetectable		 5m45D-5gsmA:
23.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M45_G_ACTG803_0
(ACETONE CARBOXYLASE
ALPHA SUBUNIT)		 5gsm EXO-BETA-D-GLUCOSAMI
NIDASE
(Thermococcus
kodakarensis) 		4 / 4 GLU A 179
PRO A 280
ILE A 277
LEU A 278
 GCS  A 801 (-2.3A)
None
None
None
 1.16A 5m45G-5gsmA:
undetectable		 5m45G-5gsmA:
23.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M45_J_ACTJ803_0
(ACETONE CARBOXYLASE
ALPHA SUBUNIT)		 5gsm EXO-BETA-D-GLUCOSAMI
NIDASE
(Thermococcus
kodakarensis) 		4 / 4 GLU A 179
PRO A 280
ILE A 277
LEU A 278
 GCS  A 801 (-2.3A)
None
None
None
 1.23A 5m45J-5gsmA:
0.0		 5m45J-5gsmA:
23.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TIX_B_OQRB302_0
(SULFOTRANSFERASE)		 5gsm EXO-BETA-D-GLUCOSAMI
NIDASE
(Thermococcus
kodakarensis) 		5 / 10 LEU A 344
LEU A 278
PHE A 307
SER A 345
GLU A 347
 None
None
None
None
GCS  A 801 (-2.7A)
 1.35A 5tixB-5gsmA:
undetectable		 5tixB-5gsmA:
14.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V5Z_A_1YNA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 5gsm EXO-BETA-D-GLUCOSAMI
NIDASE
(Thermococcus
kodakarensis) 		5 / 12 TYR A  53
ILE A  93
PHE A  28
GLY A  23
LEU A 380
 GCS  A 801 (-4.8A)
None
None
None
None
 1.41A 5v5zA-5gsmA:
undetectable		 5v5zA-5gsmA:
22.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VLM_A_CVIA301_1
(REGULATORY PROTEIN
TETR)		 5gsm EXO-BETA-D-GLUCOSAMI
NIDASE
(Thermococcus
kodakarensis) 		4 / 8 ARG A  95
VAL A  50
ASP A  51
TYR A 379
 None
None
None
GCS  A 801 (-4.2A)
 0.94A 5vlmA-5gsmA:
undetectable		 5vlmA-5gsmA:
12.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WAU_C_CHDC301_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 5gsm EXO-BETA-D-GLUCOSAMI
NIDASE
(Thermococcus
kodakarensis) 		4 / 8 HIS A  59
THR A  52
TYR A  53
LEU A 380
 None
None
GCS  A 801 (-4.8A)
None
 1.17A 5wauA-5gsmA:
undetectable
5wauC-5gsmA:
undetectable
5wauc-5gsmA:
undetectable		 5wauA-5gsmA:
21.26
5wauC-5gsmA:
16.50
5wauc-5gsmA:
16.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WAU_C_CHDC303_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 5gsm EXO-BETA-D-GLUCOSAMI
NIDASE
(Thermococcus
kodakarensis) 		4 / 7 LEU A 380
HIS A  59
THR A  52
TYR A  53
 None
None
None
GCS  A 801 (-4.8A)
 1.22A 5wauC-5gsmA:
undetectable
5waua-5gsmA:
undetectable
5wauc-5gsmA:
undetectable		 5wauC-5gsmA:
16.50
5waua-5gsmA:
21.26
5wauc-5gsmA:
16.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z84_P_CHDP301_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 5gsm EXO-BETA-D-GLUCOSAMI
NIDASE
(Thermococcus
kodakarensis) 		4 / 7 LEU A 380
HIS A  59
THR A  52
TYR A  53
 None
None
None
GCS  A 801 (-4.8A)
 1.22A 5z84C-5gsmA:
undetectable
5z84N-5gsmA:
undetectable
5z84P-5gsmA:
undetectable		 5z84C-5gsmA:
16.50
5z84N-5gsmA:
21.26
5z84P-5gsmA:
16.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z85_C_CHDC301_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 5gsm EXO-BETA-D-GLUCOSAMI
NIDASE
(Thermococcus
kodakarensis) 		4 / 8 HIS A  59
THR A  52
TYR A  53
LEU A 380
 None
None
GCS  A 801 (-4.8A)
None
 1.20A 5z85A-5gsmA:
undetectable
5z85C-5gsmA:
undetectable
5z85P-5gsmA:
undetectable		 5z85A-5gsmA:
21.26
5z85C-5gsmA:
16.50
5z85P-5gsmA:
16.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z85_P_CHDP301_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 5gsm EXO-BETA-D-GLUCOSAMI
NIDASE
(Thermococcus
kodakarensis) 		4 / 7 LEU A 380
HIS A  59
THR A  52
TYR A  53
 None
None
None
GCS  A 801 (-4.8A)
 1.20A 5z85C-5gsmA:
undetectable
5z85N-5gsmA:
undetectable
5z85P-5gsmA:
undetectable		 5z85C-5gsmA:
16.50
5z85N-5gsmA:
21.26
5z85P-5gsmA:
16.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z86_C_CHDC301_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 5gsm EXO-BETA-D-GLUCOSAMI
NIDASE
(Thermococcus
kodakarensis) 		4 / 8 HIS A  59
THR A  52
TYR A  53
LEU A 380
 None
None
GCS  A 801 (-4.8A)
None
 1.20A 5z86A-5gsmA:
undetectable
5z86C-5gsmA:
undetectable
5z86P-5gsmA:
undetectable		 5z86A-5gsmA:
21.26
5z86C-5gsmA:
16.50
5z86P-5gsmA:
16.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z86_P_CHDP301_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 5gsm EXO-BETA-D-GLUCOSAMI
NIDASE
(Thermococcus
kodakarensis) 		4 / 8 LEU A 380
HIS A  59
THR A  52
TYR A  53
 None
None
None
GCS  A 801 (-4.8A)
 1.21A 5z86C-5gsmA:
undetectable
5z86N-5gsmA:
undetectable
5z86P-5gsmA:
undetectable		 5z86C-5gsmA:
16.50
5z86N-5gsmA:
21.26
5z86P-5gsmA:
16.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZCO_C_CHDC301_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 5gsm EXO-BETA-D-GLUCOSAMI
NIDASE
(Thermococcus
kodakarensis) 		4 / 8 HIS A  59
THR A  52
TYR A  53
LEU A 380
 None
None
GCS  A 801 (-4.8A)
None
 1.22A 5zcoA-5gsmA:
undetectable
5zcoC-5gsmA:
undetectable
5zcoP-5gsmA:
undetectable		 5zcoA-5gsmA:
21.26
5zcoC-5gsmA:
16.50
5zcoP-5gsmA:
16.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZCQ_C_CHDC301_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 5gsm EXO-BETA-D-GLUCOSAMI
NIDASE
(Thermococcus
kodakarensis) 		4 / 8 HIS A  59
THR A  52
TYR A  53
LEU A 380
 None
None
GCS  A 801 (-4.8A)
None
 1.19A 5zcqA-5gsmA:
undetectable
5zcqC-5gsmA:
undetectable
5zcqP-5gsmA:
undetectable		 5zcqA-5gsmA:
21.26
5zcqC-5gsmA:
16.50
5zcqP-5gsmA:
16.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HD6_A_STIA603_1
(TYROSINE-PROTEIN
KINASE ABL1)		 5gsm EXO-BETA-D-GLUCOSAMI
NIDASE
(Thermococcus
kodakarensis) 		4 / 5 LEU A 380
TYR A 379
ILE A 160
GLY A 102
 None
GCS  A 801 (-4.2A)
None
GCS  A 801 (-3.4A)
 0.98A 6hd6A-5gsmA:
undetectable		 6hd6A-5gsmA:
7.01