SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'GCO'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NX9_A_AICA5001_1
(ALPHA-AMINO ACID
ESTER HYDROLASE)		 3t6c PUTATIVE MAND FAMILY
DEHYDRATASE
(Pantoea
ananatis) 		4 / 8 TYR A 158
TYR A 199
GLN A 154
HIS A 325
 GCO  A 601 (-4.4A)
None
None
GCO  A 601 (-3.9A)
 1.18A 1nx9A-3t6cA:
undetectable		 1nx9A-3t6cA:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NX9_B_AICB5002_1
(ALPHA-AMINO ACID
ESTER HYDROLASE)		 3t6c PUTATIVE MAND FAMILY
DEHYDRATASE
(Pantoea
ananatis) 		4 / 8 TYR A 158
TYR A 199
GLN A 154
HIS A 325
 GCO  A 601 (-4.4A)
None
None
GCO  A 601 (-3.9A)
 1.18A 1nx9B-3t6cA:
undetectable		 1nx9B-3t6cA:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NX9_C_AICC5003_1
(ALPHA-AMINO ACID
ESTER HYDROLASE)		 3t6c PUTATIVE MAND FAMILY
DEHYDRATASE
(Pantoea
ananatis) 		4 / 8 TYR A 158
TYR A 199
GLN A 154
HIS A 325
 GCO  A 601 (-4.4A)
None
None
GCO  A 601 (-3.9A)
 1.19A 1nx9C-3t6cA:
undetectable		 1nx9C-3t6cA:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NX9_D_AICD5004_1
(ALPHA-AMINO ACID
ESTER HYDROLASE)		 3t6c PUTATIVE MAND FAMILY
DEHYDRATASE
(Pantoea
ananatis) 		4 / 8 TYR A 158
TYR A 199
GLN A 154
HIS A 325
 GCO  A 601 (-4.4A)
None
None
GCO  A 601 (-3.9A)
 1.19A 1nx9D-3t6cA:
undetectable		 1nx9D-3t6cA:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UBO_B_ADNB353_2
(ADENOSINE KINASE)		 3o03 DEHYDROGENASE WITH
DIFFERENT
SPECIFICITIES
(Streptococcus
suis) 		4 / 5 SER A 150
ILE A  26
TYR A 163
GLY A 194
 GCO  A 274 ( 2.6A)
NAP  A 273 (-3.8A)
GCO  A 274 ( 4.2A)
CA  A 272 (-4.5A)
 0.94A 3uboB-3o03A:
6.6		 3uboB-3o03A:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A7A_A_RGZA601_1
(AMINE OXIDASE
[FLAVIN-CONTAINING]
B)		 3t6c PUTATIVE MAND FAMILY
DEHYDRATASE
(Pantoea
ananatis) 		5 / 11 TYR A 158
LEU A 214
GLN A 154
ILE A 151
TYR A 199
 GCO  A 601 (-4.4A)
None
None
None
None
 1.49A 4a7aA-3t6cA:
undetectable		 4a7aA-3t6cA:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V4V_A_NCAA402_0
(NADPH DEHYDROGENASE
3)		 3t6c PUTATIVE MAND FAMILY
DEHYDRATASE
(Pantoea
ananatis) 		4 / 8 HIS A 225
TYR A 158
PRO A 327
TYR A 125
 GCO  A 601 (-3.9A)
GCO  A 601 (-4.4A)
GCO  A 601 (-4.0A)
None
 1.15A 5v4vA-3t6cA:
6.9		 5v4vA-3t6cA:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V4V_B_NCAB402_0
(NADPH DEHYDROGENASE
3)		 3t6c PUTATIVE MAND FAMILY
DEHYDRATASE
(Pantoea
ananatis) 		4 / 8 HIS A 225
TYR A 158
PRO A 327
TYR A 125
 GCO  A 601 (-3.9A)
GCO  A 601 (-4.4A)
GCO  A 601 (-4.0A)
None
 1.16A 5v4vB-3t6cA:
5.8		 5v4vB-3t6cA:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B94_A_W9TA201_0
(GALECTIN-1)		 3t6c PUTATIVE MAND FAMILY
DEHYDRATASE
(Pantoea
ananatis) 		4 / 8 ASN A 338
HIS A 298
GLU A 352
ARG A 296
 None
None
GCO  A 601 (-2.8A)
GCO  A 601 (-4.1A)
 1.14A 6b94A-3t6cA:
undetectable		 6b94A-3t6cA:
11.14