SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'GBL'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XIW_B_AZMB402_1
(CARBONIC ANHYDRASE,
ALPHA TYPE)		 3sfz APOPTOTIC PEPTIDASE
ACTIVATING FACTOR 1
(Mus
musculus) 		5 / 12 HIS A 490
HIS A 457
LEU A 389
VAL A 395
PRO A 396
 None
GBL  A1251 (-4.2A)
None
None
None
 1.06A 4xiwB-3sfzA:
undetectable
4xiwE-3sfzA:
undetectable		 4xiwB-3sfzA:
10.83
4xiwE-3sfzA:
10.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XIW_B_AZMB402_1
(CARBONIC ANHYDRASE,
ALPHA TYPE)		 3sfz APOPTOTIC PEPTIDASE
ACTIVATING FACTOR 1
(Mus
musculus) 		5 / 12 HIS A 490
HIS A 457
LEU A 389
VAL A 395
PRO A 396
 None
GBL  A1251 (-4.2A)
None
None
None
 1.19A 4xiwB-3sfzA:
undetectable
4xiwE-3sfzA:
undetectable		 4xiwB-3sfzA:
10.83
4xiwE-3sfzA:
10.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AXA_C_ADNC502_2
(ADENOSYLHOMOCYSTEINA
SE)		 3sfz APOPTOTIC PEPTIDASE
ACTIVATING FACTOR 1
(Mus
musculus) 		4 / 5 GLU A 572
THR A 573
HIS A 881
LEU A 550
 None
None
None
GBL  A1254 ( 4.2A)
 1.27A 5axaC-3sfzA:
undetectable		 5axaC-3sfzA:
15.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L7I_A_VISA1202_1
(SMOOTHENED
HOMOLOG,SOLUBLE
CYTOCHROME
B562,SMOOTHENED
HOMOLOG)		 3sfz APOPTOTIC PEPTIDASE
ACTIVATING FACTOR 1
(Mus
musculus) 		5 / 12 ASN A1238
ASP A1237
TYR A1243
ASN A 551
LEU A 550
 None
None
None
GBL  A1254 (-3.4A)
GBL  A1254 ( 4.2A)
 1.48A 5l7iA-3sfzA:
2.9		 5l7iA-3sfzA:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BQG_A_ERMA1201_2
(5-HYDROXYTRYPTAMINE
RECEPTOR 2C,SOLUBLE
CYTOCHROME B562)		 3sfz APOPTOTIC PEPTIDASE
ACTIVATING FACTOR 1
(Mus
musculus) 		4 / 5 VAL A 442
THR A 446
VAL A 399
LEU A 415
 None
GBL  A1251 (-3.6A)
None
None
 0.82A 6bqgA-3sfzA:
undetectable		 6bqgA-3sfzA:
4.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NMF_P_CHDP307_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 3sfz APOPTOTIC PEPTIDASE
ACTIVATING FACTOR 1
(Mus
musculus) 		4 / 7 HIS A 457
ASP A 443
THR A 446
HIS A 490
 GBL  A1251 (-4.2A)
None
GBL  A1251 (-3.6A)
None
 1.48A 6nmfN-3sfzA:
undetectable
6nmfP-3sfzA:
undetectable		 6nmfN-3sfzA:
16.89
6nmfP-3sfzA:
11.12