SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'GBF'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LQT_B_ACTB1868_0
(FPRA)		 5v8k P800 REACTION CENTER
CORE PROTEIN
(Heliobacterium
modesticaldum) 		3 / 3 ALA A 564
HIS A 565
VAL A 568
 GBF  A1027 (-2.7A)
GBF  A1027 (-3.6A)
GBF  A1027 ( 4.3A)
 0.14A 1lqtB-5v8kA:
undetectable		 1lqtB-5v8kA:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LQU_B_ACTB1425_0
(FPRA)		 5v8k P800 REACTION CENTER
CORE PROTEIN
(Heliobacterium
modesticaldum) 		3 / 3 ALA A 564
HIS A 565
VAL A 568
 GBF  A1027 (-2.7A)
GBF  A1027 (-3.6A)
GBF  A1027 ( 4.3A)
 0.14A 1lquB-5v8kA:
undetectable		 1lquB-5v8kA:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N13_H_AG2H7012_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE ALPHA
CHAIN
PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE BETA
CHAIN)		 5v8k P800 REACTION CENTER
CORE PROTEIN
(Heliobacterium
modesticaldum) 		4 / 6 GLU A 112
LEU A  30
LEU A  37
GLY A  38
 GBF  A1010 (-3.4A)
GBF  A1011 (-3.9A)
GBF  A1008 ( 3.2A)
None
 0.89A 1n13H-5v8kA:
undetectable
1n13K-5v8kA:
undetectable		 1n13H-5v8kA:
10.93
1n13K-5v8kA:
6.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N13_J_AG2J7013_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE BETA
CHAIN
PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE ALPHA
CHAIN)		 5v8k P800 REACTION CENTER
CORE PROTEIN
(Heliobacterium
modesticaldum) 		4 / 7 LEU A  30
LEU A  37
GLY A  38
GLU A 112
 GBF  A1011 (-3.9A)
GBF  A1008 ( 3.2A)
None
GBF  A1010 (-3.4A)
 0.90A 1n13G-5v8kA:
undetectable
1n13J-5v8kA:
undetectable		 1n13G-5v8kA:
6.42
1n13J-5v8kA:
10.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QQD_B_AG2B671_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE (EC
4.1.1.19) (PVLARGDC))		 5v8k P800 REACTION CENTER
CORE PROTEIN
(Heliobacterium
modesticaldum) 		4 / 8 GLU A 112
LEU A  30
LEU A  37
GLY A  38
 GBF  A1010 (-3.4A)
GBF  A1011 (-3.9A)
GBF  A1008 ( 3.2A)
None
 0.84A 2qqdB-5v8kA:
undetectable
2qqdC-5v8kA:
undetectable		 2qqdB-5v8kA:
11.44
2qqdC-5v8kA:
14.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_G_SVRG506_3
(PHOSPHOLIPASE A2)		 5v8k P800 REACTION CENTER
CORE PROTEIN
(Heliobacterium
modesticaldum) 		3 / 3 PRO A  10
PHE A  15
LYS A  19
 GBF  A1004 (-3.8A)
GBF  A1021 (-3.1A)
None
 1.27A 3bjwG-5v8kA:
2.0		 3bjwG-5v8kA:
10.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IJI_F_BEZF501_0
(GLUTATHIONE
S-TRANSFERASE-LIKE
PROTEIN YIBF)		 5v8k P800 REACTION CENTER
CORE PROTEIN
(Heliobacterium
modesticaldum) 		4 / 8 ALA A 260
LEU A 256
ARG A 524
TYR A 525
 None
None
None
GBF  A1026 (-3.2A)
 1.16A 4ijiF-5v8kA:
undetectable		 4ijiF-5v8kA:
16.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5J4N_A_AG2A501_1
(ARGININE/AGMATINE
ANTIPORTER)		 5v8k P800 REACTION CENTER
CORE PROTEIN
(Heliobacterium
modesticaldum) 		4 / 6 SER A 545
GLY A 590
MET A 546
ILE A 539
 AOH  A1003 (-4.3A)
None
None
GBF  A1002 ( 4.4A)
 1.15A 5j4nA-5v8kA:
undetectable		 5j4nA-5v8kA:
22.82