SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'GAR'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OKC_A_SAMA500_0
(TYPE I RESTRICTION
ENZYME STYSJI M
PROTEIN)		 1c3e GLYCINAMIDE
RIBONUCLEOTIDE
TRANSFORMYLASE
(Escherichia
coli) 		5 / 12 ALA A  40
GLY A  87
THR A  53
VAL A  33
ASN A  10
 None
GAR  A 221 (-3.2A)
None
None
GAR  A 221 ( 4.7A)
 0.98A 2okcA-1c3eA:
2.6		 2okcA-1c3eA:
20.09
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3DCJ_A_THHA401_0
(PROBABLE
5'-PHOSPHORIBOSYLGLY
CINAMIDE
FORMYLTRANSFERASE
PURN)		 1c3e GLYCINAMIDE
RIBONUCLEOTIDE
TRANSFORMYLASE
(Escherichia
coli) 		5 / 12 MET A  89
ILE A  91
LEU A  92
ASN A 106
VAL A 139
 GAR  A 221 ( 4.3A)
NHR  A 220 (-4.3A)
NHR  A 220 (-3.9A)
NHR  A 220 (-3.0A)
NHR  A 220 (-4.5A)
 0.78A 3dcjA-1c3eA:
14.1
3dcjB-1c3eA:
28.4		 3dcjA-1c3eA:
32.89
3dcjB-1c3eA:
32.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G0V_A_MIXA1301_1
(DNA TOPOISOMERASE
2-BETA)		 1c3e GLYCINAMIDE
RIBONUCLEOTIDE
TRANSFORMYLASE
(Escherichia
coli) 		4 / 7 ILE A 107
ASN A  13
GLU A 173
GLN A 123
 GAR  A 221 (-4.2A)
GAR  A 221 (-4.1A)
GAR  A 221 (-2.6A)
None
 1.08A 4g0vA-1c3eA:
2.0		 4g0vA-1c3eA:
15.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XDH_B_DAHB60_1
(PUTATIVE CYTOCHROME
C)		 1c3e GLYCINAMIDE
RIBONUCLEOTIDE
TRANSFORMYLASE
(Escherichia
coli) 		4 / 5 HIS A 137
ASN A  13
VAL A  84
LEU A 104
 None
GAR  A 221 (-4.1A)
None
None
 1.25A 5xdhB-1c3eA:
undetectable		 5xdhB-1c3eA:
16.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XDH_D_DAHD60_1
(PUTATIVE CYTOCHROME
C)		 1c3e GLYCINAMIDE
RIBONUCLEOTIDE
TRANSFORMYLASE
(Escherichia
coli) 		4 / 5 HIS A 137
ASN A  13
VAL A  84
LEU A 104
 None
GAR  A 221 (-4.1A)
None
None
 1.28A 5xdhD-1c3eA:
0.0		 5xdhD-1c3eA:
16.75