SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'GAI'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_D_DCFD1853_2
(ADENOSINE DEAMINASE)		 2cev PROTEIN (ARGINASE)
([Bacillus]
caldovelox) 		4 / 4 HIS A 252
LEU A  39
LEU A  36
LEU A  95
 GAI  A1001 (-4.9A)
None
None
None
 1.20A 1a4lD-2cevA:
undetectable		 1a4lD-2cevA:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QVU_A_PRLA196_0
(TRANSCRIPTIONAL
REGULATOR QACR)		 4lyp EXO-BETA-1,4-MANNOSI
DASE
(Rhizomucor
miehei) 		4 / 6 LEU A 231
GLU A 202
TRP A 117
THR A 149
 None
GAI  A 501 ( 2.7A)
GAI  A 501 (-3.9A)
None
 1.13A 1qvuA-4lypA:
undetectable		 1qvuA-4lypA:
17.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Y7I_A_SALA501_1
(SALICYLIC
ACID-BINDING PROTEIN
2)		 2cev PROTEIN (ARGINASE)
([Bacillus]
caldovelox) 		5 / 9 GLY A 291
SER A 292
LEU A 293
LEU A 223
HIS A 252
 None
None
None
None
GAI  A1001 (-4.9A)
 1.27A 1y7iA-2cevA:
3.8		 1y7iA-2cevA:
23.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V3D_A_NBVA1503_1
(GLUCOSYLCERAMIDASE)		 4lyp EXO-BETA-1,4-MANNOSI
DASE
(Rhizomucor
miehei) 		5 / 12 ASN A 201
GLU A 202
HIS A 255
GLU A 301
TRP A 354
 TRS  A 503 ( 4.6A)
GAI  A 501 ( 2.7A)
None
TRS  A 503 (-2.6A)
TRS  A 503 (-2.9A)
 0.57A 2v3dA-4lypA:
19.6		 2v3dA-4lypA:
20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XCT_H_CPFH1020_1
(DNA GYRASE SUBUNIT
B, DNA GYRASE
SUBUNIT A)		 2ddz 190AA LONG
HYPOTHETICAL PROTEIN
(Pyrococcus
horikoshii) 		3 / 3 ARG A  12
GLU A  11
SER A 168
 GAI  A 514 (-3.9A)
None
None
 0.91A 2xctD-2ddzA:
3.8		 2xctD-2ddzA:
14.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YY8_B_SAMB500_0
(UPF0106 PROTEIN
PH0461)		 4hse CHAPERONE PROTEIN
CLPB
(Thermus
thermophilus) 		5 / 11 LEU A 211
VAL A 208
ILE A 215
GLU A 209
ALA A 212
 None
None
None
GAI  A 601 (-3.3A)
None
 1.15A 2yy8A-4hseA:
undetectable
2yy8B-4hseA:
undetectable		 2yy8A-4hseA:
21.37
2yy8B-4hseA:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IJX_B_HCZB800_1
(GLUTAMATE RECEPTOR 2)		 4itc LYS-GINGIPAIN W83
(Porphyromonas
gingivalis) 		5 / 10 LEU A1045
ILE A 993
PRO A 994
SER A 988
GLY A 992
 None
GAI  A1206 (-4.0A)
GOL  A1207 ( 4.9A)
None
None
 1.35A 3ijxB-4itcA:
undetectable
3ijxD-4itcA:
undetectable		 3ijxB-4itcA:
21.17
3ijxD-4itcA:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IK6_B_HCZB262_1
(GLUTAMATE RECEPTOR 2)		 4itc LYS-GINGIPAIN W83
(Porphyromonas
gingivalis) 		5 / 10 ILE A 993
PRO A 994
SER A 988
GLY A 992
LEU A1045
 GAI  A1206 (-4.0A)
GOL  A1207 ( 4.9A)
None
None
None
 1.38A 3ik6B-4itcA:
undetectable
3ik6E-4itcA:
undetectable		 3ik6B-4itcA:
21.17
3ik6E-4itcA:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IK6_B_HCZB800_1
(GLUTAMATE RECEPTOR 2)		 4itc LYS-GINGIPAIN W83
(Porphyromonas
gingivalis) 		5 / 10 LEU A1045
ILE A 993
PRO A 994
SER A 988
GLY A 992
 None
GAI  A1206 (-4.0A)
GOL  A1207 ( 4.9A)
None
None
 1.38A 3ik6B-4itcA:
undetectable
3ik6E-4itcA:
undetectable		 3ik6B-4itcA:
21.17
3ik6E-4itcA:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ILU_B_HFZB800_1
(GLUTAMATE RECEPTOR 2)		 4itc LYS-GINGIPAIN W83
(Porphyromonas
gingivalis) 		5 / 10 LEU A1045
ILE A 993
PRO A 994
SER A 988
GLY A 992
 None
GAI  A1206 (-4.0A)
GOL  A1207 ( 4.9A)
None
None
 1.39A 3iluB-4itcA:
undetectable
3iluE-4itcA:
undetectable		 3iluB-4itcA:
21.17
3iluE-4itcA:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ILU_E_HFZE800_1
(GLUTAMATE RECEPTOR 2)		 4itc LYS-GINGIPAIN W83
(Porphyromonas
gingivalis) 		5 / 11 ILE A 993
PRO A 994
SER A 988
GLY A 992
LEU A1045
 GAI  A1206 (-4.0A)
GOL  A1207 ( 4.9A)
None
None
None
 1.40A 3iluB-4itcA:
undetectable
3iluE-4itcA:
undetectable		 3iluB-4itcA:
21.17
3iluE-4itcA:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LSL_A_PZIA802_0
(GLUTAMATE RECEPTOR 2)		 3gnu 25 KDA PROTEIN
ELICITOR
(Pythium
aphanidermatum) 		3 / 3 ASP P  93
ASN P 194
SER P 153
 None
GAI  P 214 (-3.3A)
None
 0.68A 3lslA-3gnuP:
undetectable
3lslD-3gnuP:
undetectable		 3lslA-3gnuP:
21.92
3lslD-3gnuP:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LSL_D_PZID802_0
(GLUTAMATE RECEPTOR 2)		 3gnu 25 KDA PROTEIN
ELICITOR
(Pythium
aphanidermatum) 		3 / 3 SER P 153
ASP P  93
ASN P 194
 None
None
GAI  P 214 (-3.3A)
 0.68A 3lslA-3gnuP:
undetectable
3lslD-3gnuP:
undetectable		 3lslA-3gnuP:
21.92
3lslD-3gnuP:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NRR_A_D16A520_1
(DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 2ddz 190AA LONG
HYPOTHETICAL PROTEIN
(Pyrococcus
horikoshii) 		5 / 12 ALA A  26
PHE A  76
ILE A 132
PRO A  79
LEU A  73
 None
None
None
GAI  A 510 ( 4.8A)
None
 1.15A 3nrrA-2ddzA:
undetectable		 3nrrA-2ddzA:
16.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NRR_B_D16B520_1
(DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 2ddz 190AA LONG
HYPOTHETICAL PROTEIN
(Pyrococcus
horikoshii) 		5 / 12 ALA A  26
PHE A  76
ILE A 132
PRO A  79
LEU A  73
 None
None
None
GAI  A 510 ( 4.8A)
None
 1.12A 3nrrB-2ddzA:
undetectable		 3nrrB-2ddzA:
16.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T7S_A_SAMA300_0
(PUTATIVE
METHYLTRANSFERASE)		 3u4f MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME
FAMILY PROTEIN
(Roseovarius
nubinhibens) 		5 / 12 GLN A 256
GLN A 236
ASP A 183
SER A 118
MET A 119
 None
None
MG  A 371 ( 2.6A)
None
GAI  A 372 ( 3.7A)
 1.29A 3t7sA-3u4fA:
undetectable		 3t7sA-3u4fA:
20.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4B7N_A_ZMRA601_2
(NEURAMINIDASE)		 4kwg ALDEHYDE
DEHYDROGENASE,
MITOCHONDRIAL
(Homo
sapiens) 		3 / 3 ARG A  84
ARG A  77
TRP A  76
 None
GAI  A 605 ( 4.6A)
None
 1.22A 4b7nA-4kwgA:
undetectable		 4b7nA-4kwgA:
20.96
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4CEV_A_GAIA407_0
(PROTEIN (ARGINASE))		 2cev PROTEIN (ARGINASE)
([Bacillus]
caldovelox) 		4 / 6 ARG A 249
HIS A 252
GLU A 256
LEU A 298
 None
GAI  A1001 (-4.9A)
GAI  A1001 (-2.9A)
GAI  A1001 (-4.5A)
 0.16A 4cevA-2cevA:
57.7
4cevB-2cevA:
57.8		 4cevA-2cevA:
100.00
4cevB-2cevA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4CEV_C_GAIC409_0
(PROTEIN (ARGINASE))		 2cev PROTEIN (ARGINASE)
([Bacillus]
caldovelox) 		4 / 6 ARG A 249
HIS A 252
GLU A 256
LEU A 298
 None
GAI  A1001 (-4.9A)
GAI  A1001 (-2.9A)
GAI  A1001 (-4.5A)
 0.17A 4cevA-2cevA:
57.7
4cevC-2cevA:
58.0		 4cevA-2cevA:
100.00
4cevC-2cevA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4CEV_D_GAID410_0
(PROTEIN (ARGINASE))		 2cev PROTEIN (ARGINASE)
([Bacillus]
caldovelox) 		4 / 6 ARG A 249
HIS A 252
GLU A 256
LEU A 298
 None
GAI  A1001 (-4.9A)
GAI  A1001 (-2.9A)
GAI  A1001 (-4.5A)
 0.19A 4cevD-2cevA:
58.0
4cevE-2cevA:
58.0		 4cevD-2cevA:
100.00
4cevE-2cevA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4CEV_F_GAIF411_0
(PROTEIN (ARGINASE))		 2cev PROTEIN (ARGINASE)
([Bacillus]
caldovelox) 		4 / 6 ARG A 249
HIS A 252
GLU A 256
LEU A 298
 None
GAI  A1001 (-4.9A)
GAI  A1001 (-2.9A)
GAI  A1001 (-4.5A)
 0.19A 4cevE-2cevA:
58.0
4cevF-2cevA:
58.1		 4cevE-2cevA:
100.00
4cevF-2cevA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CPZ_C_ZMRC1470_2
(NEURAMINIDASE)		 4kwg ALDEHYDE
DEHYDROGENASE,
MITOCHONDRIAL
(Homo
sapiens) 		3 / 3 ARG A  84
ARG A  77
TRP A  76
 None
GAI  A 605 ( 4.6A)
None
 1.31A 4cpzC-4kwgA:
undetectable		 4cpzC-4kwgA:
22.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CPZ_E_ZMRE1471_2
(NEURAMINIDASE)		 4kwg ALDEHYDE
DEHYDROGENASE,
MITOCHONDRIAL
(Homo
sapiens) 		3 / 3 ARG A  84
ARG A  77
TRP A  76
 None
GAI  A 605 ( 4.6A)
None
 1.21A 4cpzE-4kwgA:
undetectable		 4cpzE-4kwgA:
22.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CPZ_F_ZMRF1470_2
(NEURAMINIDASE)		 4kwg ALDEHYDE
DEHYDROGENASE,
MITOCHONDRIAL
(Homo
sapiens) 		3 / 3 ARG A  84
ARG A  77
TRP A  76
 None
GAI  A 605 ( 4.6A)
None
 1.26A 4cpzF-4kwgA:
undetectable		 4cpzF-4kwgA:
22.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CPZ_G_ZMRG1471_2
(NEURAMINIDASE)		 4kwg ALDEHYDE
DEHYDROGENASE,
MITOCHONDRIAL
(Homo
sapiens) 		3 / 3 ARG A  84
ARG A  77
TRP A  76
 None
GAI  A 605 ( 4.6A)
None
 1.20A 4cpzG-4kwgA:
undetectable		 4cpzG-4kwgA:
22.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CPZ_H_ZMRH1470_2
(NEURAMINIDASE)		 4kwg ALDEHYDE
DEHYDROGENASE,
MITOCHONDRIAL
(Homo
sapiens) 		3 / 3 ARG A  84
ARG A  77
TRP A  76
 None
GAI  A 605 ( 4.6A)
None
 1.31A 4cpzH-4kwgA:
undetectable		 4cpzH-4kwgA:
22.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGZ_B_CQAB301_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE)		 4lyp EXO-BETA-1,4-MANNOSI
DASE
(Rhizomucor
miehei) 		4 / 8 GLY A  11
TYR A 400
LEU A 404
VAL A 407
 GAI  A 502 (-3.2A)
None
None
None
 0.77A 4fgzB-4lypA:
undetectable		 4fgzB-4lypA:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P6V_E_RBFE201_1
(NA(+)-TRANSLOCATING
NADH-QUINONE
REDUCTASE SUBUNIT B
NA(+)-TRANSLOCATING
NADH-QUINONE
REDUCTASE SUBUNIT E)		 3u4f MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME
FAMILY PROTEIN
(Roseovarius
nubinhibens) 		4 / 5 HIS A 207
VAL A 231
GLU A 209
LYS A 145
 None
None
MG  A 371 ( 2.9A)
GAI  A 372 (-2.7A)
 1.36A 4p6vB-3u4fA:
undetectable
4p6vE-3u4fA:
1.8		 4p6vB-3u4fA:
21.43
4p6vE-3u4fA:
18.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVY_K_BO2K301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 4kwg ALDEHYDE
DEHYDROGENASE,
MITOCHONDRIAL
(Homo
sapiens) 		6 / 10 ALA A  66
ALA A  68
ALA A  65
VAL A 190
GLY A 160
ASP A 237
 None
None
None
None
GAI  A 605 ( 4.1A)
None
 1.44A 4qvyK-4kwgA:
undetectable
4qvyL-4kwgA:
undetectable		 4qvyK-4kwgA:
18.37
4qvyL-4kwgA:
19.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVY_Y_BO2Y301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 4kwg ALDEHYDE
DEHYDROGENASE,
MITOCHONDRIAL
(Homo
sapiens) 		6 / 10 ALA A  66
ALA A  68
ALA A  65
VAL A 190
GLY A 160
ASP A 237
 None
None
None
None
GAI  A 605 ( 4.1A)
None
 1.45A 4qvyY-4kwgA:
undetectable
4qvyZ-4kwgA:
undetectable		 4qvyY-4kwgA:
18.37
4qvyZ-4kwgA:
19.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UCI_B_ADNB2415_1
(RNA-DIRECTED RNA
POLYMERASE L)		 3u4f MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME
FAMILY PROTEIN
(Roseovarius
nubinhibens) 		4 / 7 GLU A 209
PHE A 205
LYS A 145
HIS A 207
 MG  A 371 ( 2.9A)
None
GAI  A 372 (-2.7A)
None
 1.23A 4uciB-3u4fA:
undetectable		 4uciB-3u4fA:
20.73
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5NNW_D_GCSD302_1
(25 KDA PROTEIN
ELICITOR)		 3gnu 25 KDA PROTEIN
ELICITOR
(Pythium
aphanidermatum) 		5 / 7 ASP P  93
GLY P 100
ASP P 104
HIS P 128
ASP P 158
 None
None
None
GAI  P 214 (-4.1A)
GAI  P 214 (-2.7A)
 1.37A 5nnwD-3gnuP:
38.6		 5nnwD-3gnuP:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5NO9_D_95ZD302_1
(25 KDA PROTEIN
ELICITOR)		 3gnu 25 KDA PROTEIN
ELICITOR
(Pythium
aphanidermatum) 		5 / 7 ASP P  93
GLY P 100
ASP P 104
HIS P 128
ASP P 158
 None
None
None
GAI  P 214 (-4.1A)
GAI  P 214 (-2.7A)
 1.38A 5no9D-3gnuP:
39.0		 5no9D-3gnuP:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YF0_A_SAMA505_0
(CARNOSINE
N-METHYLTRANSFERASE)		 3u4f MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME
FAMILY PROTEIN
(Roseovarius
nubinhibens) 		5 / 12 SER A 117
MET A 119
THR A 293
TYR A 332
TYR A  34
 GAI  A 372 ( 4.3A)
GAI  A 372 ( 3.7A)
None
None
None
 1.48A 5yf0A-3u4fA:
undetectable		 5yf0A-3u4fA:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YF0_B_SAMB503_0
(CARNOSINE
N-METHYLTRANSFERASE)		 3u4f MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME
FAMILY PROTEIN
(Roseovarius
nubinhibens) 		5 / 12 SER A 117
MET A 119
THR A 293
TYR A 332
TYR A  34
 GAI  A 372 ( 4.3A)
GAI  A 372 ( 3.7A)
None
None
None
 1.48A 5yf0B-3u4fA:
0.9		 5yf0B-3u4fA:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6C2M_D_SUED1202_1
(NS3 PROTEASE)		 2cev PROTEIN (ARGINASE)
([Bacillus]
caldovelox) 		5 / 9 VAL A 198
HIS A 196
ASP A 199
LEU A 230
SER A 233
 None
None
GAI  A1003 (-3.8A)
None
None
 1.43A 6c2mD-2cevA:
undetectable		 6c2mD-2cevA:
12.37