SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'GAD'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIA_B_SAMB1293_0
(GLYCINE
N-METHYLTRANSFERASE)		 2gh4 PUTATIVE GLYCOSYL
HYDROLASE YTER
(Bacillus
subtilis) 		5 / 12 TYR A  41
ALA A  92
MET A 147
GLY A 353
HIS A  42
 GAD  A1002 ( 4.1A)
None
GAD  A1002 ( 4.3A)
None
RAM  A1001 (-3.9A)
 1.17A 1kiaB-2gh4A:
undetectable		 1kiaB-2gh4A:
22.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K13_C_THHC643_1
(5-METHYLTETRAHYDROFO
LATE-HOMOCYSTEINE
METHYLTRANSFERASE)		 2fv0 UNSATURATED
GLUCURONYL HYDROLASE
(Bacillus
sp.
GL1) 		3 / 3 ASN A  88
ASP A  41
ARG A 341
 GAD  A 404 (-2.1A)
RAM  A 402 ( 4.6A)
None
 0.87A 3k13C-2fv0A:
undetectable		 3k13C-2fv0A:
22.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A3U_A_NCAA1359_0
(NADH:FLAVIN
OXIDOREDUCTASE/NADH
OXIDASE)		 2gh4 PUTATIVE GLYCOSYL
HYDROLASE YTER
(Bacillus
subtilis) 		4 / 7 TRP A 141
HIS A 132
TYR A 136
TYR A 340
 None
GAD  A1002 (-3.9A)
None
None
 1.39A 4a3uA-2gh4A:
undetectable		 4a3uA-2gh4A:
22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A3U_B_NCAB1359_0
(NADH:FLAVIN
OXIDOREDUCTASE/NADH
OXIDASE)		 2gh4 PUTATIVE GLYCOSYL
HYDROLASE YTER
(Bacillus
subtilis) 		4 / 7 TRP A 141
HIS A 132
TYR A 136
TYR A 340
 None
GAD  A1002 (-3.9A)
None
None
 1.46A 4a3uB-2gh4A:
undetectable		 4a3uB-2gh4A:
22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FFW_A_715A801_2
(DIPEPTIDYL PEPTIDASE
4)		 2fv0 UNSATURATED
GLUCURONYL HYDROLASE
(Bacillus
sp.
GL1) 		3 / 3 PHE A  91
TYR A 228
TYR A 356
 GAD  A 404 (-4.4A)
None
None
 1.04A 4ffwA-2fv0A:
undetectable		 4ffwA-2fv0A:
18.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5C6P_A_4YHA601_1
(PROTEIN C)		 2fv0 UNSATURATED
GLUCURONYL HYDROLASE
(Bacillus
sp.
GL1) 		4 / 6 ALA A 281
SER A 280
GLN A 211
ASP A 266
 None
None
GAD  A 404 ( 3.2A)
None
 1.22A 5c6pA-2fv0A:
undetectable		 5c6pA-2fv0A:
22.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FA8_A_SAMA301_0
(RIBOSOMAL PROTEIN
L11
METHYLTRANSFERASE,
PUTATIVE)		 2fv0 UNSATURATED
GLUCURONYL HYDROLASE
(Bacillus
sp.
GL1) 		5 / 12 GLY A 226
GLY A 222
ARG A 221
ILE A 284
PHE A 230
 None
None
GAD  A 404 (-4.0A)
None
None
 1.09A 5fa8A-2fv0A:
undetectable		 5fa8A-2fv0A:
15.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KVA_A_SAMA301_1
(CAFFEOYL-COA
O-METHYLTRANSFERASE)		 2fv0 UNSATURATED
GLUCURONYL HYDROLASE
(Bacillus
sp.
GL1) 		3 / 3 THR A 218
SER A 191
ASP A 149
 None
None
GAD  A 404 (-3.8A)
 0.45A 5kvaA-2fv0A:
undetectable		 5kvaA-2fv0A:
18.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KVA_B_SAMB301_1
(CAFFEOYL-COA
O-METHYLTRANSFERASE)		 2fv0 UNSATURATED
GLUCURONYL HYDROLASE
(Bacillus
sp.
GL1) 		3 / 3 THR A 218
SER A 191
ASP A 149
 None
None
GAD  A 404 (-3.8A)
 0.47A 5kvaB-2fv0A:
undetectable		 5kvaB-2fv0A:
18.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EXI_C_ADNC502_1
(ADENOSYLHOMOCYSTEINA
SE)		 2fv0 UNSATURATED
GLUCURONYL HYDROLASE
(Bacillus
sp.
GL1) 		3 / 3 LEU A 184
GLY A 222
PHE A  91
 None
None
GAD  A 404 (-4.4A)
 0.57A 6exiC-2fv0A:
undetectable		 6exiC-2fv0A:
13.87