SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'GA4'


List of Similar Pattern of Amino Acids


Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID
Hit
Macromolecule
Res.
Matches
Interface HETATM RMSD Dali
Z-score
Seq.
Identity (%)
View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GAH_A_ACRA497_2
(GLUCOAMYLASE-471)
3ebl GIBBERELLIN RECEPTOR
GID1

(Oryza
sativa)
4 / 6 ALA A 269
SER A 195
ARG A 251
LEU A 259
None
None
GA4  A 401 (-3.8A)
None
1.23A 1gahA-3eblA:
undetectable
1gahA-3eblA:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIA_A_SAMA293_0
(GLYCINE
N-METHYLTRANSFERASE)
3ebl GIBBERELLIN RECEPTOR
GID1

(Oryza
sativa)
5 / 12 ILE A 133
SER A 293
GLY A 121
SER A 198
TYR A 134
None
None
GA4  A 401 ( 4.6A)
GA4  A 401 (-2.6A)
GA4  A 401 (-4.8A)
1.05A 1kiaA-3eblA:
2.0
1kiaA-3eblA:
22.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIA_A_SAMA293_0
(GLYCINE
N-METHYLTRANSFERASE)
3ebl GIBBERELLIN RECEPTOR
GID1

(Oryza
sativa)
5 / 12 ILE A 133
SER A 293
GLY A 122
SER A 198
TYR A 134
None
None
GA4  A 401 (-2.9A)
GA4  A 401 (-2.6A)
GA4  A 401 (-4.8A)
1.00A 1kiaA-3eblA:
2.0
1kiaA-3eblA:
22.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJ2_A_SAMA2201_1
(PROTEIN (METHIONINE
REPRESSOR))
2zsi PROBABLE GIBBERELLIN
RECEPTOR GID1L1

(Arabidopsis
thaliana)
4 / 4 HIS A 119
ALA A 118
PHE A 117
GLY A 115
None
None
None
GA4  A 345 (-3.1A)
1.25A 1mj2B-2zsiA:
undetectable
1mj2B-2zsiA:
13.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJ2_C_SAMC1200_1
(PROTEIN (METHIONINE
REPRESSOR))
2zsi PROBABLE GIBBERELLIN
RECEPTOR GID1L1

(Arabidopsis
thaliana)
4 / 4 HIS A 119
ALA A 118
PHE A 117
GLY A 115
None
None
None
GA4  A 345 (-3.1A)
1.17A 1mj2D-2zsiA:
undetectable
1mj2D-2zsiA:
13.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJO_A_SAMA199_1
(METHIONINE REPRESSOR)
2zsi PROBABLE GIBBERELLIN
RECEPTOR GID1L1

(Arabidopsis
thaliana)
4 / 4 HIS A 119
ALA A 118
PHE A 117
GLY A 115
None
None
None
GA4  A 345 (-3.1A)
1.22A 1mjoB-2zsiA:
undetectable
1mjoB-2zsiA:
13.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJO_B_SAMB200_0
(METHIONINE REPRESSOR)
2zsi PROBABLE GIBBERELLIN
RECEPTOR GID1L1

(Arabidopsis
thaliana)
4 / 4 HIS A 119
ALA A 118
PHE A 117
GLY A 115
None
None
None
GA4  A 345 (-3.1A)
1.26A 1mjoA-2zsiA:
undetectable
1mjoA-2zsiA:
13.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJO_D_SAMD200_1
(METHIONINE REPRESSOR)
2zsi PROBABLE GIBBERELLIN
RECEPTOR GID1L1

(Arabidopsis
thaliana)
4 / 4 HIS A 119
ALA A 118
PHE A 117
GLY A 115
None
None
None
GA4  A 345 (-3.1A)
1.21A 1mjoD-2zsiA:
undetectable
1mjoD-2zsiA:
13.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OT7_B_IU5B1002_1
(BILE ACID RECEPTOR)
2zsi DELLA PROTEIN GAI
PROBABLE GIBBERELLIN
RECEPTOR GID1L1

(Arabidopsis
thaliana)
5 / 12 LEU A 323
HIS A 113
ILE A  24
TYR B  36
TYR A  31
None
None
GA4  A 345 ( 4.3A)
None
None
1.45A 1ot7B-2zsiA:
undetectable
1ot7B-2zsiA:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XVA_B_SAMB293_0
(GLYCINE
N-METHYLTRANSFERASE)
3ebl GIBBERELLIN RECEPTOR
GID1

(Oryza
sativa)
5 / 12 TYR A  31
SER A 128
HIS A 120
ILE A  24
TYR A 134
MPD  A 501 ( 4.9A)
None
None
GA4  A 401 (-4.2A)
GA4  A 401 (-4.8A)
1.31A 1xvaB-3eblA:
2.7
1xvaB-3eblA:
22.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2GSS_A_EAAA0_1
(GLUTATHIONE
S-TRANSFERASE P1-1)
3ebl GIBBERELLIN RECEPTOR
GID1

(Oryza
sativa)
4 / 8 TYR A  31
ILE A 133
TYR A 134
GLY A 121
MPD  A 501 ( 4.9A)
None
GA4  A 401 (-4.8A)
GA4  A 401 ( 4.6A)
0.93A 2gssA-3eblA:
undetectable
2gssA-3eblA:
19.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2GSS_B_EAAB0_1
(GLUTATHIONE
S-TRANSFERASE P1-1)
3ebl GIBBERELLIN RECEPTOR
GID1

(Oryza
sativa)
4 / 8 TYR A  31
ILE A 133
TYR A 134
GLY A 121
MPD  A 501 ( 4.9A)
None
GA4  A 401 (-4.8A)
GA4  A 401 ( 4.6A)
0.93A 2gssB-3eblA:
undetectable
2gssB-3eblA:
19.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GSS_B_EAAB211_1
(GLUTATHIONE
S-TRANSFERASE P1-1)
3ebl GIBBERELLIN RECEPTOR
GID1

(Oryza
sativa)
4 / 7 TYR A  31
ILE A 133
TYR A 134
GLY A 121
MPD  A 501 ( 4.9A)
None
GA4  A 401 (-4.8A)
GA4  A 401 ( 4.6A)
0.94A 3gssB-3eblA:
undetectable
3gssB-3eblA:
19.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_M_TFPM201_1
(PROTEIN S100-A4)
3ebl GIBBERELLIN RECEPTOR
GID1

(Oryza
sativa)
4 / 7 GLY A 121
MET A 341
GLY A 327
PHE A 328
GA4  A 401 ( 4.6A)
None
GA4  A 401 (-2.9A)
None
0.87A 3ko0M-3eblA:
undetectable
3ko0P-3eblA:
0.4
3ko0M-3eblA:
14.95
3ko0P-3eblA:
14.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UGR_A_IMNA2001_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C3)
2zsi PROBABLE GIBBERELLIN
RECEPTOR GID1L1

(Arabidopsis
thaliana)
5 / 12 SER A 191
MET A 220
TYR A 127
SER A 124
PHE A 117
GA4  A 345 (-3.1A)
None
GA4  A 345 (-4.7A)
None
None
1.32A 3ugrA-2zsiA:
undetectable
3ugrA-2zsiA:
22.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UGR_A_IMNA2001_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C3)
3ebl GIBBERELLIN RECEPTOR
GID1

(Oryza
sativa)
5 / 12 SER A 198
MET A 227
TYR A 134
SER A 131
PHE A 124
GA4  A 401 (-2.6A)
None
GA4  A 401 (-4.8A)
None
None
1.40A 3ugrA-3eblA:
undetectable
3ugrA-3eblA:
24.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A81_A_DXCA1161_0
(MAJOR POLLEN
ALLERGEN BET V 1-A)
3ebl GIBBERELLIN RECEPTOR
GID1

(Oryza
sativa)
5 / 12 ILE A 203
GLY A 196
ASP A 197
TYR A 154
ASN A 153
None
None
GA4  A 401 (-4.2A)
None
None
0.97A 4a81A-3eblA:
undetectable
4a81A-3eblA:
20.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7X_F_SASF805_1
(SEPIAPTERIN
REDUCTASE)
2zsi PROBABLE GIBBERELLIN
RECEPTOR GID1L1

(Arabidopsis
thaliana)
5 / 12 LEU A 130
CYH A 131
PHE A 111
TYR A  81
GLY A 115
None
None
None
None
GA4  A 345 (-3.1A)
1.30A 4j7xF-2zsiA:
3.6
4j7xF-2zsiA:
23.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KRH_B_SAMB900_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE
2)
2zsi PROBABLE GIBBERELLIN
RECEPTOR GID1L1

(Arabidopsis
thaliana)
5 / 12 TYR A 127
GLY A 193
GLY A 189
SER A 144
ALA A 158
GA4  A 345 (-4.7A)
None
None
None
None
1.15A 4krhB-2zsiA:
3.1
4krhB-2zsiA:
23.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KRH_B_SAMB900_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE
2)
3ebl GIBBERELLIN RECEPTOR
GID1

(Oryza
sativa)
5 / 12 TYR A 134
GLY A 200
GLY A 196
SER A 151
ALA A 165
GA4  A 401 (-4.8A)
None
None
None
None
1.11A 4krhB-3eblA:
3.3
4krhB-3eblA:
24.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LNW_A_T3A502_1
(THYROID HORMONE
RECEPTOR ALPHA)
2zsi DELLA PROTEIN GAI
PROBABLE GIBBERELLIN
RECEPTOR GID1L1

(Arabidopsis
thaliana)
4 / 8 SER A  25
GLU B  54
VAL A 319
THR A 318
None
None
GA4  A 345 (-4.2A)
None
1.10A 4lnwA-2zsiA:
undetectable
4lnwA-2zsiA:
23.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QT3_A_RAPA202_1
(FK506-BINDING
PROTEIN (FKBP)-TYPE
PEPTIDYL-PROPYL
ISOMERASE)
3ebl GIBBERELLIN RECEPTOR
GID1

(Oryza
sativa)
5 / 10 ASP A 197
PHE A 328
GLU A 339
VAL A 340
ILE A 344
GA4  A 401 (-4.2A)
None
None
None
None
1.45A 4qt3A-3eblA:
undetectable
4qt3A-3eblA:
17.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5H3A_A_D16A401_1
(ORF70)
3ebl GIBBERELLIN RECEPTOR
GID1

(Oryza
sativa)
5 / 7 ILE A 117
ASP A 197
GLY A 200
PHE A 119
TYR A 329
None
GA4  A 401 (-4.2A)
None
None
None
1.49A 5h3aA-3eblA:
undetectable
5h3aA-3eblA:
19.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5W4Z_A_RBFA502_1
(RIBOFLAVIN LYASE)
2zsi PROBABLE GIBBERELLIN
RECEPTOR GID1L1

(Arabidopsis
thaliana)
5 / 12 ALA A 122
GLY A 115
GLY A 162
ALA A 165
SER A 192
None
GA4  A 345 (-3.1A)
None
None
None
0.95A 5w4zA-2zsiA:
undetectable
5w4zA-2zsiA:
12.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5W4Z_A_RBFA502_1
(RIBOFLAVIN LYASE)
3ebl GIBBERELLIN RECEPTOR
GID1

(Oryza
sativa)
5 / 12 ALA A 129
GLY A 122
GLY A 169
ALA A 172
SER A 199
None
GA4  A 401 (-2.9A)
None
None
None
0.94A 5w4zA-3eblA:
undetectable
5w4zA-3eblA:
14.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5W4Z_B_RBFB502_1
(RIBOFLAVIN LYASE)
2zsi PROBABLE GIBBERELLIN
RECEPTOR GID1L1

(Arabidopsis
thaliana)
5 / 12 ALA A 122
GLY A 115
GLY A 162
ALA A 165
SER A 192
None
GA4  A 345 (-3.1A)
None
None
None
0.96A 5w4zB-2zsiA:
undetectable
5w4zB-2zsiA:
12.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5W4Z_B_RBFB502_1
(RIBOFLAVIN LYASE)
3ebl GIBBERELLIN RECEPTOR
GID1

(Oryza
sativa)
5 / 12 ALA A 129
GLY A 122
GLY A 169
ALA A 172
SER A 199
None
GA4  A 401 (-2.9A)
None
None
None
0.95A 5w4zB-3eblA:
undetectable
5w4zB-3eblA:
14.77