SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'G93'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FMO_E_ADNE351_1
(CAMP-DEPENDENT
PROTEIN KINASE)		 5u94 SERINE/THREONINE-PRO
TEIN KINASE PKNB
(Mycobacterium
tuberculosis) 		8 / 12 LEU A  17
GLY A  18
VAL A  25
ALA A  38
VAL A  72
VAL A  95
ASN A 143
ASP A 156
 G93  A 301 ( 3.8A)
G93  A 301 ( 3.2A)
G93  A 301 (-3.4A)
G93  A 301 ( 3.7A)
G93  A 301 (-4.0A)
G93  A 301 (-4.1A)
MG  A 310 (-3.2A)
G93  A 301 ( 3.2A)
 0.54A 1fmoE-5u94A:
27.6		 1fmoE-5u94A:
14.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IEP_B_STIB202_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL)		 5u94 SERINE/THREONINE-PRO
TEIN KINASE PKNB
(Mycobacterium
tuberculosis) 		4 / 7 LYS A  40
VAL A  72
ILE A  90
ARG A 137
 G93  A 301 (-3.0A)
G93  A 301 (-4.0A)
G93  A 301 ( 3.8A)
None
 1.01A 1iepB-5u94A:
18.9		 1iepB-5u94A:
16.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OPJ_B_STIB4_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 5u94 SERINE/THREONINE-PRO
TEIN KINASE PKNB
(Mycobacterium
tuberculosis) 		4 / 6 LEU A  17
LYS A  40
ILE A  90
ARG A 137
 G93  A 301 ( 3.8A)
G93  A 301 (-3.0A)
G93  A 301 ( 3.8A)
None
 0.94A 1opjB-5u94A:
18.7		 1opjB-5u94A:
16.96
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2FUM_A_MIXA539_1
(PROBABLE
SERINE/THREONINE-PRO
TEIN KINASE PKNB)		 5u94 SERINE/THREONINE-PRO
TEIN KINASE PKNB
(Mycobacterium
tuberculosis) 		12 / 12 LEU A  17
GLY A  18
VAL A  25
ALA A  38
VAL A  95
ASP A 138
LYS A 140
ALA A 142
ASN A 143
MET A 145
MET A 155
ASP A 156
 G93  A 301 ( 3.8A)
G93  A 301 ( 3.2A)
G93  A 301 (-3.4A)
G93  A 301 ( 3.7A)
G93  A 301 (-4.1A)
None
G93  A 301 ( 4.3A)
G93  A 301 ( 3.1A)
MG  A 310 (-3.2A)
G93  A 301 ( 3.7A)
G93  A 301 (-3.4A)
G93  A 301 ( 3.2A)
 0.57A 2fumA-5u94A:
40.4		 2fumA-5u94A:
84.04
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2FUM_B_MIXB1539_1
(PROBABLE
SERINE/THREONINE-PRO
TEIN KINASE PKNB)		 5u94 SERINE/THREONINE-PRO
TEIN KINASE PKNB
(Mycobacterium
tuberculosis) 		12 / 12 LEU A  17
GLY A  18
VAL A  25
ALA A  38
MET A  92
TYR A  94
VAL A  95
LYS A 140
ASN A 143
MET A 145
MET A 155
ASP A 156
 G93  A 301 ( 3.8A)
G93  A 301 ( 3.2A)
G93  A 301 (-3.4A)
G93  A 301 ( 3.7A)
G93  A 301 (-2.7A)
None
G93  A 301 (-4.1A)
G93  A 301 ( 4.3A)
MG  A 310 (-3.2A)
G93  A 301 ( 3.7A)
G93  A 301 (-3.4A)
G93  A 301 ( 3.2A)
 0.57A 2fumB-5u94A:
40.7		 2fumB-5u94A:
84.04
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2FUM_C_MIXC2539_1
(PROBABLE
SERINE/THREONINE-PRO
TEIN KINASE PKNB)		 5u94 SERINE/THREONINE-PRO
TEIN KINASE PKNB
(Mycobacterium
tuberculosis) 		11 / 12 LEU A  17
GLY A  18
VAL A  25
ALA A  38
MET A  92
TYR A  94
VAL A  95
THR A  99
ASN A 143
MET A 145
MET A 155
 G93  A 301 ( 3.8A)
G93  A 301 ( 3.2A)
G93  A 301 (-3.4A)
G93  A 301 ( 3.7A)
G93  A 301 (-2.7A)
None
G93  A 301 (-4.1A)
None
MG  A 310 (-3.2A)
G93  A 301 ( 3.7A)
G93  A 301 (-3.4A)
 0.54A 2fumC-5u94A:
38.0		 2fumC-5u94A:
84.04
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2FUM_D_MIXD3539_1
(PROBABLE
SERINE/THREONINE-PRO
TEIN KINASE PKNB)		 5u94 SERINE/THREONINE-PRO
TEIN KINASE PKNB
(Mycobacterium
tuberculosis) 		9 / 12 LEU A  17
GLY A  18
GLY A  20
VAL A  25
ALA A  38
MET A  92
THR A  99
ASN A 143
MET A 145
 G93  A 301 ( 3.8A)
G93  A 301 ( 3.2A)
None
G93  A 301 (-3.4A)
G93  A 301 ( 3.7A)
G93  A 301 (-2.7A)
None
MG  A 310 (-3.2A)
G93  A 301 ( 3.7A)
 0.73A 2fumD-5u94A:
37.9		 2fumD-5u94A:
84.04
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2FUM_D_MIXD3539_1
(PROBABLE
SERINE/THREONINE-PRO
TEIN KINASE PKNB)		 5u94 SERINE/THREONINE-PRO
TEIN KINASE PKNB
(Mycobacterium
tuberculosis) 		10 / 12 LEU A  17
GLY A  18
VAL A  25
ALA A  38
MET A  92
THR A  99
LYS A 140
ASN A 143
MET A 145
MET A 155
 G93  A 301 ( 3.8A)
G93  A 301 ( 3.2A)
G93  A 301 (-3.4A)
G93  A 301 ( 3.7A)
G93  A 301 (-2.7A)
None
G93  A 301 ( 4.3A)
MG  A 310 (-3.2A)
G93  A 301 ( 3.7A)
G93  A 301 (-3.4A)
 0.64A 2fumD-5u94A:
37.9		 2fumD-5u94A:
84.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HYY_B_STIB600_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 5u94 SERINE/THREONINE-PRO
TEIN KINASE PKNB
(Mycobacterium
tuberculosis) 		4 / 6 LEU A  17
LYS A  40
VAL A  72
ILE A  90
 G93  A 301 ( 3.8A)
G93  A 301 (-3.0A)
G93  A 301 (-4.0A)
G93  A 301 ( 3.8A)
 0.72A 2hyyB-5u94A:
24.1		 2hyyB-5u94A:
15.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IVU_A_ZD6A3015_0
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE RECEPTOR RET
PRECURSOR)		 5u94 SERINE/THREONINE-PRO
TEIN KINASE PKNB
(Mycobacterium
tuberculosis) 		6 / 12 LEU A  17
GLY A  18
VAL A  25
LYS A  40
GLU A  59
TYR A  94
 G93  A 301 ( 3.8A)
G93  A 301 ( 3.2A)
G93  A 301 (-3.4A)
G93  A 301 (-3.0A)
G93  A 301 (-3.2A)
None
 0.53A 2ivuA-5u94A:
19.2		 2ivuA-5u94A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AQI_B_CHDB4_0
(FERROCHELATASE)		 5u94 SERINE/THREONINE-PRO
TEIN KINASE PKNB
(Mycobacterium
tuberculosis) 		4 / 6 MET A 155
ARG A 101
GLY A  20
MET A  22
 G93  A 301 (-3.4A)
None
None
None
 1.49A 3aqiB-5u94A:
undetectable		 3aqiB-5u94A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CS9_A_NILA600_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 5u94 SERINE/THREONINE-PRO
TEIN KINASE PKNB
(Mycobacterium
tuberculosis) 		5 / 10 LEU A  17
VAL A  25
LYS A  40
VAL A  72
ILE A  90
 G93  A 301 ( 3.8A)
G93  A 301 (-3.4A)
G93  A 301 (-3.0A)
G93  A 301 (-4.0A)
G93  A 301 ( 3.8A)
 0.66A 3cs9A-5u94A:
15.0		 3cs9A-5u94A:
16.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CS9_A_NILA600_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 5u94 SERINE/THREONINE-PRO
TEIN KINASE PKNB
(Mycobacterium
tuberculosis) 		5 / 10 LEU A  17
VAL A  25
VAL A  72
ILE A  90
VAL A 154
 G93  A 301 ( 3.8A)
G93  A 301 (-3.4A)
G93  A 301 (-4.0A)
G93  A 301 ( 3.8A)
None
 0.73A 3cs9A-5u94A:
15.0		 3cs9A-5u94A:
16.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CS9_B_NILB600_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 5u94 SERINE/THREONINE-PRO
TEIN KINASE PKNB
(Mycobacterium
tuberculosis) 		5 / 9 LEU A  17
VAL A  25
LYS A  40
VAL A  72
ILE A  90
 G93  A 301 ( 3.8A)
G93  A 301 (-3.4A)
G93  A 301 (-3.0A)
G93  A 301 (-4.0A)
G93  A 301 ( 3.8A)
 0.60A 3cs9B-5u94A:
19.5		 3cs9B-5u94A:
16.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CS9_B_NILB600_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 5u94 SERINE/THREONINE-PRO
TEIN KINASE PKNB
(Mycobacterium
tuberculosis) 		5 / 9 LEU A  17
VAL A  25
VAL A  72
ILE A  90
VAL A 154
 G93  A 301 ( 3.8A)
G93  A 301 (-3.4A)
G93  A 301 (-4.0A)
G93  A 301 ( 3.8A)
None
 0.65A 3cs9B-5u94A:
19.5		 3cs9B-5u94A:
16.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CS9_C_NILC600_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 5u94 SERINE/THREONINE-PRO
TEIN KINASE PKNB
(Mycobacterium
tuberculosis) 		5 / 9 LEU A  17
VAL A  25
LYS A  40
VAL A  72
ILE A  90
 G93  A 301 ( 3.8A)
G93  A 301 (-3.4A)
G93  A 301 (-3.0A)
G93  A 301 (-4.0A)
G93  A 301 ( 3.8A)
 0.66A 3cs9C-5u94A:
19.5		 3cs9C-5u94A:
16.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CS9_C_NILC600_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 5u94 SERINE/THREONINE-PRO
TEIN KINASE PKNB
(Mycobacterium
tuberculosis) 		5 / 9 LEU A  17
VAL A  25
VAL A  72
ILE A  90
VAL A 154
 G93  A 301 ( 3.8A)
G93  A 301 (-3.4A)
G93  A 301 (-4.0A)
G93  A 301 ( 3.8A)
None
 0.71A 3cs9C-5u94A:
19.5		 3cs9C-5u94A:
16.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EYG_A_MI1A1_1
(TYROSINE-PROTEIN
KINASE)		 5u94 SERINE/THREONINE-PRO
TEIN KINASE PKNB
(Mycobacterium
tuberculosis) 		8 / 12 LEU A  17
GLY A  18
VAL A  25
ALA A  38
LYS A  40
MET A  92
ASN A 143
ASP A 156
 G93  A 301 ( 3.8A)
G93  A 301 ( 3.2A)
G93  A 301 (-3.4A)
G93  A 301 ( 3.7A)
G93  A 301 (-3.0A)
G93  A 301 (-2.7A)
MG  A 310 (-3.2A)
G93  A 301 ( 3.2A)
 0.68A 3eygA-5u94A:
26.8		 3eygA-5u94A:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FUP_A_MI1A1_1
(TYROSINE-PROTEIN
KINASE JAK2)		 5u94 SERINE/THREONINE-PRO
TEIN KINASE PKNB
(Mycobacterium
tuberculosis) 		8 / 12 LEU A  17
GLY A  18
VAL A  25
ALA A  38
LYS A  40
MET A  92
TYR A  94
ASP A 156
 G93  A 301 ( 3.8A)
G93  A 301 ( 3.2A)
G93  A 301 (-3.4A)
G93  A 301 ( 3.7A)
G93  A 301 (-3.0A)
G93  A 301 (-2.7A)
None
G93  A 301 ( 3.2A)
 0.68A 3fupA-5u94A:
26.8		 3fupA-5u94A:
13.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FUP_B_MI1B1_1
(TYROSINE-PROTEIN
KINASE JAK2)		 5u94 SERINE/THREONINE-PRO
TEIN KINASE PKNB
(Mycobacterium
tuberculosis) 		9 / 12 LEU A  17
GLY A  18
GLY A  20
VAL A  25
ALA A  38
LYS A  40
VAL A  72
MET A  92
TYR A  94
 G93  A 301 ( 3.8A)
G93  A 301 ( 3.2A)
None
G93  A 301 (-3.4A)
G93  A 301 ( 3.7A)
G93  A 301 (-3.0A)
G93  A 301 (-4.0A)
G93  A 301 (-2.7A)
None
 0.58A 3fupB-5u94A:
26.8		 3fupB-5u94A:
13.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G0E_A_B49A9000_1
(MAST/STEM CELL
GROWTH FACTOR
RECEPTOR)		 5u94 SERINE/THREONINE-PRO
TEIN KINASE PKNB
(Mycobacterium
tuberculosis) 		6 / 11 LEU A  17
VAL A  25
ALA A  38
VAL A  72
TYR A  94
GLY A  97
 G93  A 301 ( 3.8A)
G93  A 301 (-3.4A)
G93  A 301 ( 3.7A)
G93  A 301 (-4.0A)
None
GOL  A 305 ( 4.3A)
 0.58A 3g0eA-5u94A:
16.3		 3g0eA-5u94A:
14.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G5D_A_1N1A1_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 5u94 SERINE/THREONINE-PRO
TEIN KINASE PKNB
(Mycobacterium
tuberculosis) 		7 / 12 LEU A  17
VAL A  25
ALA A  38
GLU A  59
VAL A  72
ILE A  90
TYR A  94
 G93  A 301 ( 3.8A)
G93  A 301 (-3.4A)
G93  A 301 ( 3.7A)
G93  A 301 (-3.2A)
G93  A 301 (-4.0A)
G93  A 301 ( 3.8A)
None
 0.54A 3g5dA-5u94A:
26.8		 3g5dA-5u94A:
15.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IK3_A_0LIA1_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 5u94 SERINE/THREONINE-PRO
TEIN KINASE PKNB
(Mycobacterium
tuberculosis) 		4 / 7 LEU A  17
LYS A  40
ILE A  90
ARG A 137
 G93  A 301 ( 3.8A)
G93  A 301 (-3.0A)
G93  A 301 ( 3.8A)
None
 0.98A 3ik3A-5u94A:
5.3		 3ik3A-5u94A:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IK3_B_0LIB2_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 5u94 SERINE/THREONINE-PRO
TEIN KINASE PKNB
(Mycobacterium
tuberculosis) 		4 / 7 LEU A  17
LYS A  40
ILE A  90
ARG A 137
 G93  A 301 ( 3.8A)
G93  A 301 (-3.0A)
G93  A 301 ( 3.8A)
None
 0.92A 3ik3B-5u94A:
18.0		 3ik3B-5u94A:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K5V_A_STIA2_2
(TYROSINE-PROTEIN
KINASE ABL1)		 5u94 SERINE/THREONINE-PRO
TEIN KINASE PKNB
(Mycobacterium
tuberculosis) 		4 / 6 LEU A  17
LYS A  40
VAL A  72
ILE A  90
 G93  A 301 ( 3.8A)
G93  A 301 (-3.0A)
G93  A 301 (-4.0A)
G93  A 301 ( 3.8A)
 0.69A 3k5vA-5u94A:
18.5		 3k5vA-5u94A:
16.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K5V_B_STIB2_2
(TYROSINE-PROTEIN
KINASE ABL1)		 5u94 SERINE/THREONINE-PRO
TEIN KINASE PKNB
(Mycobacterium
tuberculosis) 		4 / 6 LEU A  17
LYS A  40
VAL A  72
ILE A  90
 G93  A 301 ( 3.8A)
G93  A 301 (-3.0A)
G93  A 301 (-4.0A)
G93  A 301 ( 3.8A)
 0.72A 3k5vB-5u94A:
23.4		 3k5vB-5u94A:
16.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LXK_A_MI1A1125_1
(TYROSINE-PROTEIN
KINASE JAK3)		 5u94 SERINE/THREONINE-PRO
TEIN KINASE PKNB
(Mycobacterium
tuberculosis) 		9 / 12 LEU A  17
GLY A  18
VAL A  25
ALA A  38
LYS A  40
VAL A  72
MET A  92
TYR A  94
ASP A 156
 G93  A 301 ( 3.8A)
G93  A 301 ( 3.2A)
G93  A 301 (-3.4A)
G93  A 301 ( 3.7A)
G93  A 301 (-3.0A)
G93  A 301 (-4.0A)
G93  A 301 (-2.7A)
None
G93  A 301 ( 3.2A)
 0.76A 3lxkA-5u94A:
26.4		 3lxkA-5u94A:
15.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LXN_A_MI1A1_1
(NON-RECEPTOR
TYROSINE-PROTEIN
KINASE TYK2)		 5u94 SERINE/THREONINE-PRO
TEIN KINASE PKNB
(Mycobacterium
tuberculosis) 		7 / 12 LEU A  17
GLY A  18
VAL A  25
ALA A  38
LYS A  40
TYR A  94
VAL A  95
 G93  A 301 ( 3.8A)
G93  A 301 ( 3.2A)
G93  A 301 (-3.4A)
G93  A 301 ( 3.7A)
G93  A 301 (-3.0A)
None
G93  A 301 (-4.1A)
 0.44A 3lxnA-5u94A:
27.0		 3lxnA-5u94A:
14.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MS9_A_STIA1_2
(TYROSINE-PROTEIN
KINASE ABL1)		 5u94 SERINE/THREONINE-PRO
TEIN KINASE PKNB
(Mycobacterium
tuberculosis) 		4 / 6 LYS A  40
VAL A  72
ILE A  90
ARG A 137
 G93  A 301 (-3.0A)
G93  A 301 (-4.0A)
G93  A 301 ( 3.8A)
None
 0.93A 3ms9A-5u94A:
2.7		 3ms9A-5u94A:
16.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MSS_A_STIA1_2
(TYROSINE-PROTEIN
KINASE ABL1)		 5u94 SERINE/THREONINE-PRO
TEIN KINASE PKNB
(Mycobacterium
tuberculosis) 		4 / 6 LYS A  40
VAL A  72
ILE A  90
ARG A 137
 G93  A 301 (-3.0A)
G93  A 301 (-4.0A)
G93  A 301 ( 3.8A)
None
 0.94A 3mssA-5u94A:
19.0		 3mssA-5u94A:
16.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MSS_C_STIC1_2
(TYROSINE-PROTEIN
KINASE ABL1)		 5u94 SERINE/THREONINE-PRO
TEIN KINASE PKNB
(Mycobacterium
tuberculosis) 		4 / 6 LYS A  40
VAL A  72
ILE A  90
ARG A 137
 G93  A 301 (-3.0A)
G93  A 301 (-4.0A)
G93  A 301 ( 3.8A)
None
 0.96A 3mssC-5u94A:
18.9		 3mssC-5u94A:
16.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MSS_D_STID1_2
(TYROSINE-PROTEIN
KINASE ABL1)		 5u94 SERINE/THREONINE-PRO
TEIN KINASE PKNB
(Mycobacterium
tuberculosis) 		4 / 6 VAL A  25
LYS A  40
VAL A  72
ILE A  90
 G93  A 301 (-3.4A)
G93  A 301 (-3.0A)
G93  A 301 (-4.0A)
G93  A 301 ( 3.8A)
 0.69A 3mssD-5u94A:
23.5		 3mssD-5u94A:
16.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WAR_A_NIOA401_1
(CASEIN KINASE II
SUBUNIT ALPHA)		 5u94 SERINE/THREONINE-PRO
TEIN KINASE PKNB
(Mycobacterium
tuberculosis) 		4 / 8 VAL A  25
LYS A  40
MET A 145
ASP A 156
 G93  A 301 (-3.4A)
G93  A 301 (-3.0A)
G93  A 301 ( 3.7A)
G93  A 301 ( 3.2A)
 0.60A 3warA-5u94A:
25.5		 3warA-5u94A:
15.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BKJ_B_STIB1000_2
(EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1)		 5u94 SERINE/THREONINE-PRO
TEIN KINASE PKNB
(Mycobacterium
tuberculosis) 		4 / 5 LYS A  40
LEU A  66
TYR A  94
ARG A 137
 G93  A 301 (-3.0A)
None
None
None
 1.38A 4bkjB-5u94A:
24.5		 4bkjB-5u94A:
15.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CKJ_A_ADNA2014_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE RECEPTOR RET)		 5u94 SERINE/THREONINE-PRO
TEIN KINASE PKNB
(Mycobacterium
tuberculosis) 		6 / 10 LEU A  17
GLY A  18
GLY A  20
VAL A  25
ALA A  38
TYR A  94
 G93  A 301 ( 3.8A)
G93  A 301 ( 3.2A)
None
G93  A 301 (-3.4A)
G93  A 301 ( 3.7A)
None
 0.21A 4ckjA-5u94A:
22.1		 4ckjA-5u94A:
14.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MXO_A_DB8A601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 5u94 SERINE/THREONINE-PRO
TEIN KINASE PKNB
(Mycobacterium
tuberculosis) 		8 / 12 LEU A  17
VAL A  25
ALA A  38
LYS A  40
GLU A  59
ILE A  90
TYR A  94
ASP A 156
 G93  A 301 ( 3.8A)
G93  A 301 (-3.4A)
G93  A 301 ( 3.7A)
G93  A 301 (-3.0A)
G93  A 301 (-3.2A)
G93  A 301 ( 3.8A)
None
G93  A 301 ( 3.2A)
 0.83A 4mxoA-5u94A:
26.9		 4mxoA-5u94A:
15.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MXY_A_DB8A601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 5u94 SERINE/THREONINE-PRO
TEIN KINASE PKNB
(Mycobacterium
tuberculosis) 		8 / 12 LEU A  17
VAL A  25
ALA A  38
GLU A  59
VAL A  72
ILE A  90
TYR A  94
ASP A 156
 G93  A 301 ( 3.8A)
G93  A 301 (-3.4A)
G93  A 301 ( 3.7A)
G93  A 301 (-3.2A)
G93  A 301 (-4.0A)
G93  A 301 ( 3.8A)
None
G93  A 301 ( 3.2A)
 0.95A 4mxyA-5u94A:
20.3		 4mxyA-5u94A:
15.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MXZ_A_DB8A601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 5u94 SERINE/THREONINE-PRO
TEIN KINASE PKNB
(Mycobacterium
tuberculosis) 		8 / 12 LEU A  17
VAL A  25
ALA A  38
GLU A  59
VAL A  72
ILE A  90
TYR A  94
ASP A 156
 G93  A 301 ( 3.8A)
G93  A 301 (-3.4A)
G93  A 301 ( 3.7A)
G93  A 301 (-3.2A)
G93  A 301 (-4.0A)
G93  A 301 ( 3.8A)
None
G93  A 301 ( 3.2A)
 0.95A 4mxzA-5u94A:
20.3		 4mxzA-5u94A:
15.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O0S_A_ADNA500_1
(AURORA KINASE A)		 5u94 SERINE/THREONINE-PRO
TEIN KINASE PKNB
(Mycobacterium
tuberculosis) 		8 / 11 LEU A  17
GLY A  18
VAL A  25
ALA A  38
LYS A  40
THR A  99
ASN A 143
ASP A 156
 G93  A 301 ( 3.8A)
G93  A 301 ( 3.2A)
G93  A 301 (-3.4A)
G93  A 301 ( 3.7A)
G93  A 301 (-3.0A)
None
MG  A 310 (-3.2A)
G93  A 301 ( 3.2A)
 0.95A 4o0sA-5u94A:
30.1		 4o0sA-5u94A:
12.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QMS_A_1N1A401_1
(SERINE/THREONINE-PRO
TEIN KINASE 24)		 5u94 SERINE/THREONINE-PRO
TEIN KINASE PKNB
(Mycobacterium
tuberculosis) 		6 / 11 ALA A  38
LYS A  40
GLU A  59
ILE A  90
TYR A  94
ASP A 156
 G93  A 301 ( 3.7A)
G93  A 301 (-3.0A)
G93  A 301 (-3.2A)
G93  A 301 ( 3.8A)
None
G93  A 301 ( 3.2A)
 0.78A 4qmsA-5u94A:
29.8		 4qmsA-5u94A:
16.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R7I_A_STIA1001_2
(MACROPHAGE
COLONY-STIMULATING
FACTOR 1 RECEPTOR)		 5u94 SERINE/THREONINE-PRO
TEIN KINASE PKNB
(Mycobacterium
tuberculosis) 		4 / 5 LEU A  17
VAL A  72
TYR A  94
ARG A 137
 G93  A 301 ( 3.8A)
G93  A 301 (-4.0A)
None
None
 0.39A 4r7iA-5u94A:
24.5		 4r7iA-5u94A:
13.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4U0I_A_0LIA1001_1
(MAST/STEM CELL
GROWTH FACTOR
RECEPTOR
KIT,MAST/STEM CELL
GROWTH FACTOR
RECEPTOR KIT)		 5u94 SERINE/THREONINE-PRO
TEIN KINASE PKNB
(Mycobacterium
tuberculosis) 		8 / 10 LEU A  17
VAL A  25
GLU A  59
LEU A  66
ILE A  71
VAL A  72
TYR A  94
ARG A 137
 G93  A 301 ( 3.8A)
G93  A 301 (-3.4A)
G93  A 301 (-3.2A)
None
None
G93  A 301 (-4.0A)
None
None
 0.95A 4u0iA-5u94A:
24.8		 4u0iA-5u94A:
15.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XV2_A_P06A801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 5u94 SERINE/THREONINE-PRO
TEIN KINASE PKNB
(Mycobacterium
tuberculosis) 		5 / 12 VAL A  25
ALA A  38
LYS A  40
ASP A 156
PHE A 157
 G93  A 301 (-3.4A)
G93  A 301 ( 3.7A)
G93  A 301 (-3.0A)
G93  A 301 ( 3.2A)
G93  A 301 (-4.8A)
 0.74A 4xv2A-5u94A:
21.6		 4xv2A-5u94A:
13.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HES_B_032B401_1
(MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE MLT)		 5u94 SERINE/THREONINE-PRO
TEIN KINASE PKNB
(Mycobacterium
tuberculosis) 		6 / 12 VAL A  25
ALA A  38
LYS A  40
ILE A  90
TYR A  94
ASP A 102
 G93  A 301 (-3.4A)
G93  A 301 ( 3.7A)
G93  A 301 (-3.0A)
G93  A 301 ( 3.8A)
None
None
 0.79A 5hesB-5u94A:
23.6		 5hesB-5u94A:
14.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HES_B_032B401_1
(MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE MLT)		 5u94 SERINE/THREONINE-PRO
TEIN KINASE PKNB
(Mycobacterium
tuberculosis) 		6 / 12 VAL A  25
ALA A  38
LYS A  40
TYR A  94
ASP A 102
GLY A 158
 G93  A 301 (-3.4A)
G93  A 301 ( 3.7A)
G93  A 301 (-3.0A)
None
None
G93  A 301 ( 4.9A)
 1.35A 5hesB-5u94A:
23.6		 5hesB-5u94A:
14.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IZJ_G_AZ1G2_1
(CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA
47P-AZ1-DAR-DAR)		 5u94 SERINE/THREONINE-PRO
TEIN KINASE PKNB
(Mycobacterium
tuberculosis) 		4 / 7 GLY A  18
GLY A  20
VAL A  25
LYS A  40
 G93  A 301 ( 3.2A)
None
G93  A 301 (-3.4A)
G93  A 301 (-3.0A)
 0.22A 5izjA-5u94A:
27.5		 5izjA-5u94A:
13.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5J5X_B_AZ1B2_1
(CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA
47P-AZ1-DAL-DAR-DAR-
DAR-DAR)		 5u94 SERINE/THREONINE-PRO
TEIN KINASE PKNB
(Mycobacterium
tuberculosis) 		5 / 7 GLY A  18
GLY A  20
VAL A  25
LYS A  40
ASP A 156
 G93  A 301 ( 3.2A)
None
G93  A 301 (-3.4A)
G93  A 301 (-3.0A)
G93  A 301 ( 3.2A)
 0.61A 5j5xA-5u94A:
27.6		 5j5xA-5u94A:
13.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LVN_A_ADNA402_1
(3-PHOSPHOINOSITIDE-D
EPENDENT PROTEIN
KINASE 1)		 5u94 SERINE/THREONINE-PRO
TEIN KINASE PKNB
(Mycobacterium
tuberculosis) 		6 / 11 LEU A  17
GLY A  18
VAL A  25
ALA A  38
VAL A  72
TYR A  94
 G93  A 301 ( 3.8A)
G93  A 301 ( 3.2A)
G93  A 301 (-3.4A)
G93  A 301 ( 3.7A)
G93  A 301 (-4.0A)
None
 0.36A 5lvnA-5u94A:
21.4		 5lvnA-5u94A:
14.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MO4_A_NILA601_1
(TYROSINE-PROTEIN
KINASE ABL1)		 5u94 SERINE/THREONINE-PRO
TEIN KINASE PKNB
(Mycobacterium
tuberculosis) 		6 / 10 LEU A  17
VAL A  25
LYS A  40
GLU A  59
ILE A  90
GLY A  97
 G93  A 301 ( 3.8A)
G93  A 301 (-3.4A)
G93  A 301 (-3.0A)
G93  A 301 (-3.2A)
G93  A 301 ( 3.8A)
GOL  A 305 ( 4.3A)
 0.72A 5mo4A-5u94A:
18.3		 5mo4A-5u94A:
11.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N3H_A_NCAA401_0
(CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA)		 5u94 SERINE/THREONINE-PRO
TEIN KINASE PKNB
(Mycobacterium
tuberculosis) 		7 / 10 LEU A  17
VAL A  25
ALA A  38
VAL A  72
MET A  92
TYR A  94
VAL A  95
 G93  A 301 ( 3.8A)
G93  A 301 (-3.4A)
G93  A 301 ( 3.7A)
G93  A 301 (-4.0A)
G93  A 301 (-2.7A)
None
G93  A 301 (-4.1A)
 0.73A 5n3hA-5u94A:
27.9		 5n3hA-5u94A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TE0_A_XINA401_1
(AP2-ASSOCIATED
PROTEIN KINASE 1)		 5u94 SERINE/THREONINE-PRO
TEIN KINASE PKNB
(Mycobacterium
tuberculosis) 		6 / 12 GLU A  15
LEU A  27
ALA A  38
GLU A  59
VAL A  72
GLY A  97
 None
GOL  A 307 ( 3.8A)
G93  A 301 ( 3.7A)
G93  A 301 (-3.2A)
G93  A 301 (-4.0A)
GOL  A 305 ( 4.3A)
 0.63A 5te0A-5u94A:
27.7		 5te0A-5u94A:
12.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UL4_A_SAMA803_0
(OXSB PROTEIN)		 5u94 SERINE/THREONINE-PRO
TEIN KINASE PKNB
(Mycobacterium
tuberculosis) 		5 / 12 ARG A  55
GLY A 158
GLU A  59
ILE A  90
LEU A  87
 None
G93  A 301 ( 4.9A)
G93  A 301 (-3.2A)
G93  A 301 ( 3.8A)
None
 1.21A 5ul4A-5u94A:
2.2		 5ul4A-5u94A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VCY_A_DB8A401_1
(MEMBRANE-ASSOCIATED
TYROSINE- AND
THREONINE-SPECIFIC
CDC2-INHIBITORY
KINASE)		 5u94 SERINE/THREONINE-PRO
TEIN KINASE PKNB
(Mycobacterium
tuberculosis) 		6 / 12 LEU A  17
VAL A  25
ALA A  38
LYS A  40
GLU A  59
GLY A  97
 G93  A 301 ( 3.8A)
G93  A 301 (-3.4A)
G93  A 301 ( 3.7A)
G93  A 301 (-3.0A)
G93  A 301 (-3.2A)
GOL  A 305 ( 4.3A)
 0.89A 5vcyA-5u94A:
27.0		 5vcyA-5u94A:
15.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5W5V_A_ANWA701_0
(SERINE/THREONINE-PRO
TEIN KINASE TBK1)		 5u94 SERINE/THREONINE-PRO
TEIN KINASE PKNB
(Mycobacterium
tuberculosis) 		5 / 9 LEU A  17
ALA A  38
VAL A  72
GLY A  97
MET A 145
 G93  A 301 ( 3.8A)
G93  A 301 ( 3.7A)
G93  A 301 (-4.0A)
GOL  A 305 ( 4.3A)
G93  A 301 ( 3.7A)
 0.99A 5w5vA-5u94A:
5.4		 5w5vA-5u94A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y9M_X_NIOX401_1
(CASEIN KINASE II
SUBUNIT ALPHA')		 5u94 SERINE/THREONINE-PRO
TEIN KINASE PKNB
(Mycobacterium
tuberculosis) 		4 / 8 VAL A  25
LYS A  40
MET A 145
ASP A 156
 G93  A 301 (-3.4A)
G93  A 301 (-3.0A)
G93  A 301 ( 3.7A)
G93  A 301 ( 3.2A)
 0.54A 5y9mX-5u94A:
25.0		 5y9mX-5u94A:
22.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YF9_B_NIOB401_1
(CASEIN KINASE II
SUBUNIT ALPHA')		 5u94 SERINE/THREONINE-PRO
TEIN KINASE PKNB
(Mycobacterium
tuberculosis) 		4 / 7 VAL A  25
LYS A  40
MET A 145
ASP A 156
 G93  A 301 (-3.4A)
G93  A 301 (-3.0A)
G93  A 301 ( 3.7A)
G93  A 301 ( 3.2A)
 0.77A 5yf9B-5u94A:
25.2		 5yf9B-5u94A:
22.94