SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'G76'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RQJ_A_RISA901_1
(GERANYLTRANSTRANSFER
ASE)		 5ahu FARNESYL
PYROPHOSPHATE
SYNTHASE
(Trypanosoma
brucei) 		10 / 11 LEU B 100
ASP B 103
ASP B 107
ARG B 112
GLN B 172
LYS B 212
THR B 213
GLN B 252
ASP B 255
LYS B 269
 None
MG  B1370 (-2.5A)
MG  B1369 (-2.2A)
G76  B1368 (-2.8A)
G76  B1368 ( 4.1A)
G76  B1368 (-2.8A)
G76  B1368 (-4.2A)
G76  B1368 ( 4.0A)
MG  B1371 ( 3.0A)
G76  B1368 (-3.1A)
 0.57A 1rqjA-5ahuB:
22.5		 1rqjA-5ahuB:
24.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RQJ_B_RISB903_1
(GERANYLTRANSTRANSFER
ASE)		 5ahu FARNESYL
PYROPHOSPHATE
SYNTHASE
(Trypanosoma
brucei) 		10 / 11 LEU B 100
ASP B 103
ASP B 107
ARG B 112
GLN B 172
LYS B 212
THR B 213
GLN B 252
ASP B 255
LYS B 269
 None
MG  B1370 (-2.5A)
MG  B1369 (-2.2A)
G76  B1368 (-2.8A)
G76  B1368 ( 4.1A)
G76  B1368 (-2.8A)
G76  B1368 (-4.2A)
G76  B1368 ( 4.0A)
MG  B1371 ( 3.0A)
G76  B1368 (-3.1A)
 0.59A 1rqjB-5ahuB:
22.6		 1rqjB-5ahuB:
24.30
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1YHL_A_RISA1400_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 5ahu FARNESYL
PYROPHOSPHATE
SYNTHASE
(Trypanosoma
brucei) 		11 / 11 LEU B 100
ASP B 103
ASP B 107
ARG B 112
GLN B 172
LYS B 212
THR B 213
TYR B 216
GLN B 252
ASP B 255
LYS B 269
 None
MG  B1370 (-2.5A)
MG  B1369 (-2.2A)
G76  B1368 (-2.8A)
G76  B1368 ( 4.1A)
G76  B1368 (-2.8A)
G76  B1368 (-4.2A)
None
G76  B1368 ( 4.0A)
MG  B1371 ( 3.0A)
G76  B1368 (-3.1A)
 0.53A 1yhlA-5ahuB:
39.9		 1yhlA-5ahuB:
73.47
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1YQ7_A_RISA901_1
(FARNESYL
PYROPHOSPHATE
SYNTHETASE)		 5ahu FARNESYL
PYROPHOSPHATE
SYNTHASE
(Trypanosoma
brucei) 		5 / 11 LEU B 100
ARG B 112
THR B 217
TYR B 216
LYS B 269
 None
G76  B1368 (-2.8A)
None
None
G76  B1368 (-3.1A)
 1.46A 1yq7A-5ahuB:
32.7		 1yq7A-5ahuB:
33.42
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1YQ7_A_RISA901_1
(FARNESYL
PYROPHOSPHATE
SYNTHETASE)		 5ahu FARNESYL
PYROPHOSPHATE
SYNTHASE
(Trypanosoma
brucei) 		11 / 11 LEU B 100
ASP B 103
ASP B 107
ARG B 112
GLN B 172
LYS B 212
THR B 213
TYR B 216
GLN B 252
ASP B 255
LYS B 269
 None
MG  B1370 (-2.5A)
MG  B1369 (-2.2A)
G76  B1368 (-2.8A)
G76  B1368 ( 4.1A)
G76  B1368 (-2.8A)
G76  B1368 (-4.2A)
None
G76  B1368 ( 4.0A)
MG  B1371 ( 3.0A)
G76  B1368 (-3.1A)
 0.57A 1yq7A-5ahuB:
32.7		 1yq7A-5ahuB:
33.42
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1YV5_A_RISA901_1
(FARNESYL
PYROPHOSPHATE
SYNTHETASE)		 5ahu FARNESYL
PYROPHOSPHATE
SYNTHASE
(Trypanosoma
brucei) 		5 / 10 ASP B 107
ARG B 112
GLN B 252
ASP B 255
LYS B 269
 MG  B1369 (-2.2A)
G76  B1368 (-2.8A)
G76  B1368 ( 4.0A)
MG  B1371 ( 3.0A)
G76  B1368 (-3.1A)
 1.17A 1yv5A-5ahuB:
33.0		 1yv5A-5ahuB:
33.42
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1YV5_A_RISA901_1
(FARNESYL
PYROPHOSPHATE
SYNTHETASE)		 5ahu FARNESYL
PYROPHOSPHATE
SYNTHASE
(Trypanosoma
brucei) 		10 / 10 LEU B 100
ASP B 103
ASP B 107
ARG B 112
GLN B 172
LYS B 212
THR B 213
GLN B 252
ASP B 255
LYS B 269
 None
MG  B1370 (-2.5A)
MG  B1369 (-2.2A)
G76  B1368 (-2.8A)
G76  B1368 ( 4.1A)
G76  B1368 (-2.8A)
G76  B1368 (-4.2A)
G76  B1368 ( 4.0A)
MG  B1371 ( 3.0A)
G76  B1368 (-3.1A)
 0.46A 1yv5A-5ahuB:
33.0		 1yv5A-5ahuB:
33.42
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1ZW5_A_ZOLA901_1
(FARNESYL DIPHOSPHATE
SYNTHASE)		 5ahu FARNESYL
PYROPHOSPHATE
SYNTHASE
(Trypanosoma
brucei) 		9 / 9 ASP B 103
ASP B 107
ARG B 112
GLN B 172
LYS B 212
THR B 213
GLN B 252
ASP B 255
LYS B 269
 MG  B1370 (-2.5A)
MG  B1369 (-2.2A)
G76  B1368 (-2.8A)
G76  B1368 ( 4.1A)
G76  B1368 (-2.8A)
G76  B1368 (-4.2A)
G76  B1368 ( 4.0A)
MG  B1371 ( 3.0A)
G76  B1368 (-3.1A)
 0.51A 1zw5A-5ahuB:
18.4		 1zw5A-5ahuB:
33.42
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1ZW5_A_ZOLA901_1
(FARNESYL DIPHOSPHATE
SYNTHASE)		 5ahu FARNESYL
PYROPHOSPHATE
SYNTHASE
(Trypanosoma
brucei) 		5 / 9 ASP B 107
ARG B 112
GLN B 252
ASP B 255
LYS B 269
 MG  B1369 (-2.2A)
G76  B1368 (-2.8A)
G76  B1368 ( 4.0A)
MG  B1371 ( 3.0A)
G76  B1368 (-3.1A)
 1.16A 1zw5A-5ahuB:
18.4		 1zw5A-5ahuB:
33.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2E91_A_ZOLA901_1
(GERANYLGERANYL
PYROPHOSPHATE
SYNTHETASE)		 5ahu FARNESYL
PYROPHOSPHATE
SYNTHASE
(Trypanosoma
brucei) 		6 / 9 ASP B 103
ASP B 107
ARG B 112
GLN B 172
LYS B 212
LYS B 278
 MG  B1370 (-2.5A)
MG  B1369 (-2.2A)
G76  B1368 (-2.8A)
G76  B1368 ( 4.1A)
G76  B1368 (-2.8A)
MG  B1369 (-3.6A)
 1.24A 2e91A-5ahuB:
22.0		 2e91A-5ahuB:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2E91_A_ZOLA901_1
(GERANYLGERANYL
PYROPHOSPHATE
SYNTHETASE)		 5ahu FARNESYL
PYROPHOSPHATE
SYNTHASE
(Trypanosoma
brucei) 		8 / 9 ASP B 103
ASP B 107
ARG B 112
GLN B 172
LYS B 212
THR B 213
GLN B 252
ASP B 255
 MG  B1370 (-2.5A)
MG  B1369 (-2.2A)
G76  B1368 (-2.8A)
G76  B1368 ( 4.1A)
G76  B1368 (-2.8A)
G76  B1368 (-4.2A)
G76  B1368 ( 4.0A)
MG  B1371 ( 3.0A)
 0.53A 2e91A-5ahuB:
22.0		 2e91A-5ahuB:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2E91_B_ZOLB902_1
(GERANYLGERANYL
PYROPHOSPHATE
SYNTHETASE)		 5ahu FARNESYL
PYROPHOSPHATE
SYNTHASE
(Trypanosoma
brucei) 		6 / 9 ASP B 103
ASP B 107
ARG B 112
GLN B 172
LYS B 212
LYS B 278
 MG  B1370 (-2.5A)
MG  B1369 (-2.2A)
G76  B1368 (-2.8A)
G76  B1368 ( 4.1A)
G76  B1368 (-2.8A)
MG  B1369 (-3.6A)
 1.27A 2e91B-5ahuB:
22.2		 2e91B-5ahuB:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2E91_B_ZOLB902_1
(GERANYLGERANYL
PYROPHOSPHATE
SYNTHETASE)		 5ahu FARNESYL
PYROPHOSPHATE
SYNTHASE
(Trypanosoma
brucei) 		8 / 9 ASP B 103
ASP B 107
ARG B 112
GLN B 172
LYS B 212
THR B 213
GLN B 252
ASP B 255
 MG  B1370 (-2.5A)
MG  B1369 (-2.2A)
G76  B1368 (-2.8A)
G76  B1368 ( 4.1A)
G76  B1368 (-2.8A)
G76  B1368 (-4.2A)
G76  B1368 ( 4.0A)
MG  B1371 ( 3.0A)
 0.61A 2e91B-5ahuB:
22.2		 2e91B-5ahuB:
21.57
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2F89_F_210F9001_1
(FARNESYL DIPHOSPHATE
SYNTHASE)		 5ahu FARNESYL
PYROPHOSPHATE
SYNTHASE
(Trypanosoma
brucei) 		9 / 9 ASP B 103
ASP B 107
ARG B 112
LYS B 212
THR B 213
TYR B 216
GLN B 252
ASP B 255
LYS B 269
 MG  B1370 (-2.5A)
MG  B1369 (-2.2A)
G76  B1368 (-2.8A)
G76  B1368 (-2.8A)
G76  B1368 (-4.2A)
None
G76  B1368 ( 4.0A)
MG  B1371 ( 3.0A)
G76  B1368 (-3.1A)
 0.31A 2f89F-5ahuB:
16.6		 2f89F-5ahuB:
33.79
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2F89_F_210F9001_1
(FARNESYL DIPHOSPHATE
SYNTHASE)		 5ahu FARNESYL
PYROPHOSPHATE
SYNTHASE
(Trypanosoma
brucei) 		5 / 9 ASP B 107
ARG B 112
GLN B 252
ASP B 255
LYS B 269
 MG  B1369 (-2.2A)
G76  B1368 (-2.8A)
G76  B1368 ( 4.0A)
MG  B1371 ( 3.0A)
G76  B1368 (-3.1A)
 1.18A 2f89F-5ahuB:
16.6		 2f89F-5ahuB:
33.79
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2F8C_F_ZOLF9001_1
(FARNESYL DIPHOSPHATE
SYNTHASE)		 5ahu FARNESYL
PYROPHOSPHATE
SYNTHASE
(Trypanosoma
brucei) 		5 / 11 ASP B 107
ARG B 112
GLN B 252
ASP B 255
LYS B 269
 MG  B1369 (-2.2A)
G76  B1368 (-2.8A)
G76  B1368 ( 4.0A)
MG  B1371 ( 3.0A)
G76  B1368 (-3.1A)
 1.16A 2f8cF-5ahuB:
16.8		 2f8cF-5ahuB:
33.79
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2F8C_F_ZOLF9001_1
(FARNESYL DIPHOSPHATE
SYNTHASE)		 5ahu FARNESYL
PYROPHOSPHATE
SYNTHASE
(Trypanosoma
brucei) 		5 / 11 LEU B 100
ARG B 112
THR B 217
TYR B 216
LYS B 269
 None
G76  B1368 (-2.8A)
None
None
G76  B1368 (-3.1A)
 1.45A 2f8cF-5ahuB:
16.8		 2f8cF-5ahuB:
33.79
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2F8C_F_ZOLF9001_1
(FARNESYL DIPHOSPHATE
SYNTHASE)		 5ahu FARNESYL
PYROPHOSPHATE
SYNTHASE
(Trypanosoma
brucei) 		11 / 11 LEU B 100
ASP B 103
ASP B 107
ARG B 112
GLN B 172
LYS B 212
THR B 213
TYR B 216
GLN B 252
ASP B 255
LYS B 269
 None
MG  B1370 (-2.5A)
MG  B1369 (-2.2A)
G76  B1368 (-2.8A)
G76  B1368 ( 4.1A)
G76  B1368 (-2.8A)
G76  B1368 (-4.2A)
None
G76  B1368 ( 4.0A)
MG  B1371 ( 3.0A)
G76  B1368 (-3.1A)
 0.45A 2f8cF-5ahuB:
16.8		 2f8cF-5ahuB:
33.79
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2F8Z_F_ZOLF5001_1
(FARNESYL DIPHOSPHATE
SYNTHASE)		 5ahu FARNESYL
PYROPHOSPHATE
SYNTHASE
(Trypanosoma
brucei) 		5 / 10 ASP B 107
ARG B 112
GLN B 252
ASP B 255
LYS B 269
 MG  B1369 (-2.2A)
G76  B1368 (-2.8A)
G76  B1368 ( 4.0A)
MG  B1371 ( 3.0A)
G76  B1368 (-3.1A)
 1.12A 2f8zF-5ahuB:
16.5		 2f8zF-5ahuB:
33.79
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2F8Z_F_ZOLF5001_1
(FARNESYL DIPHOSPHATE
SYNTHASE)		 5ahu FARNESYL
PYROPHOSPHATE
SYNTHASE
(Trypanosoma
brucei) 		10 / 10 LEU B 100
ASP B 103
ASP B 107
ARG B 112
GLN B 172
LYS B 212
THR B 213
GLN B 252
ASP B 255
LYS B 269
 None
MG  B1370 (-2.5A)
MG  B1369 (-2.2A)
G76  B1368 (-2.8A)
G76  B1368 ( 4.1A)
G76  B1368 (-2.8A)
G76  B1368 (-4.2A)
G76  B1368 ( 4.0A)
MG  B1371 ( 3.0A)
G76  B1368 (-3.1A)
 0.50A 2f8zF-5ahuB:
16.5		 2f8zF-5ahuB:
33.79
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2F94_F_BFQF9001_1
(FARNESYL DIPHOSPHATE
SYNTHASE)		 5ahu FARNESYL
PYROPHOSPHATE
SYNTHASE
(Trypanosoma
brucei) 		12 / 12 LEU B 100
ASP B 103
ASP B 107
ARG B 112
THR B 168
GLN B 172
LYS B 212
THR B 213
TYR B 216
GLN B 252
ASP B 255
LYS B 269
 None
MG  B1370 (-2.5A)
MG  B1369 (-2.2A)
G76  B1368 (-2.8A)
None
G76  B1368 ( 4.1A)
G76  B1368 (-2.8A)
G76  B1368 (-4.2A)
None
G76  B1368 ( 4.0A)
MG  B1371 ( 3.0A)
G76  B1368 (-3.1A)
 0.46A 2f94F-5ahuB:
17.0		 2f94F-5ahuB:
33.79
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2F9K_F_ZOLF9001_1
(FARNESYL DIPHOSPHATE
SYNTHASE)		 5ahu FARNESYL
PYROPHOSPHATE
SYNTHASE
(Trypanosoma
brucei) 		10 / 10 LEU B 100
ASP B 103
ASP B 107
ARG B 112
GLN B 172
LYS B 212
THR B 213
GLN B 252
ASP B 255
LYS B 269
 None
MG  B1370 (-2.5A)
MG  B1369 (-2.2A)
G76  B1368 (-2.8A)
G76  B1368 ( 4.1A)
G76  B1368 (-2.8A)
G76  B1368 (-4.2A)
G76  B1368 ( 4.0A)
MG  B1371 ( 3.0A)
G76  B1368 (-3.1A)
 0.48A 2f9kF-5ahuB:
15.9		 2f9kF-5ahuB:
33.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2O1O_A_RISA400_1
(PUTATIVE FARNESYL
PYROPHOSPHATE
SYNTHASE)		 5ahu FARNESYL
PYROPHOSPHATE
SYNTHASE
(Trypanosoma
brucei) 		8 / 9 LEU B 100
ASP B 103
ASP B 107
ARG B 112
GLN B 172
LYS B 212
THR B 213
GLN B 252
 None
MG  B1370 (-2.5A)
MG  B1369 (-2.2A)
G76  B1368 (-2.8A)
G76  B1368 ( 4.1A)
G76  B1368 (-2.8A)
G76  B1368 (-4.2A)
G76  B1368 ( 4.0A)
 0.60A 2o1oA-5ahuB:
13.2		 2o1oA-5ahuB:
24.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2O1O_B_RISB400_1
(PUTATIVE FARNESYL
PYROPHOSPHATE
SYNTHASE)		 5ahu FARNESYL
PYROPHOSPHATE
SYNTHASE
(Trypanosoma
brucei) 		7 / 10 LEU B 100
ASP B 103
ASP B 107
ARG B 112
GLN B 172
LYS B 212
LYS B 278
 None
MG  B1370 (-2.5A)
MG  B1369 (-2.2A)
G76  B1368 (-2.8A)
G76  B1368 ( 4.1A)
G76  B1368 (-2.8A)
MG  B1369 (-3.6A)
 0.99A 2o1oB-5ahuB:
14.2		 2o1oB-5ahuB:
24.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2O1O_B_RISB400_1
(PUTATIVE FARNESYL
PYROPHOSPHATE
SYNTHASE)		 5ahu FARNESYL
PYROPHOSPHATE
SYNTHASE
(Trypanosoma
brucei) 		8 / 10 LEU B 100
ASP B 103
ASP B 107
ARG B 112
GLN B 172
LYS B 212
THR B 213
GLN B 252
 None
MG  B1370 (-2.5A)
MG  B1369 (-2.2A)
G76  B1368 (-2.8A)
G76  B1368 ( 4.1A)
G76  B1368 (-2.8A)
G76  B1368 (-4.2A)
G76  B1368 ( 4.0A)
 0.63A 2o1oB-5ahuB:
14.2		 2o1oB-5ahuB:
24.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q58_A_ZOLA1_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 5ahu FARNESYL
PYROPHOSPHATE
SYNTHASE
(Trypanosoma
brucei) 		8 / 10 ASP B 103
ASP B 107
ARG B 112
GLN B 172
LYS B 212
THR B 213
GLN B 252
ASP B 256
 MG  B1370 (-2.5A)
MG  B1369 (-2.2A)
G76  B1368 (-2.8A)
G76  B1368 ( 4.1A)
G76  B1368 (-2.8A)
G76  B1368 (-4.2A)
G76  B1368 ( 4.0A)
None
 0.76A 2q58A-5ahuB:
27.1		 2q58A-5ahuB:
24.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q58_A_ZOLA1_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 5ahu FARNESYL
PYROPHOSPHATE
SYNTHASE
(Trypanosoma
brucei) 		8 / 10 LEU B 100
ASP B 103
ASP B 107
ARG B 112
LYS B 212
THR B 213
GLN B 252
ASP B 256
 None
MG  B1370 (-2.5A)
MG  B1369 (-2.2A)
G76  B1368 (-2.8A)
G76  B1368 (-2.8A)
G76  B1368 (-4.2A)
G76  B1368 ( 4.0A)
None
 0.70A 2q58A-5ahuB:
27.1		 2q58A-5ahuB:
24.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q58_B_ZOLB2_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 5ahu FARNESYL
PYROPHOSPHATE
SYNTHASE
(Trypanosoma
brucei) 		6 / 9 ASP B 103
ASP B 107
ARG B 112
GLN B 172
LYS B 212
LYS B 278
 MG  B1370 (-2.5A)
MG  B1369 (-2.2A)
G76  B1368 (-2.8A)
G76  B1368 ( 4.1A)
G76  B1368 (-2.8A)
MG  B1369 (-3.6A)
 1.12A 2q58B-5ahuB:
27.3		 2q58B-5ahuB:
24.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q58_B_ZOLB2_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 5ahu FARNESYL
PYROPHOSPHATE
SYNTHASE
(Trypanosoma
brucei) 		7 / 9 ASP B 103
ASP B 107
ARG B 112
GLN B 172
LYS B 212
THR B 213
GLN B 252
 MG  B1370 (-2.5A)
MG  B1369 (-2.2A)
G76  B1368 (-2.8A)
G76  B1368 ( 4.1A)
G76  B1368 (-2.8A)
G76  B1368 (-4.2A)
G76  B1368 ( 4.0A)
 0.74A 2q58B-5ahuB:
27.3		 2q58B-5ahuB:
24.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2QIS_A_RISA901_1
(FARNESYL
PYROPHOSPHATE
SYNTHETASE)		 5ahu FARNESYL
PYROPHOSPHATE
SYNTHASE
(Trypanosoma
brucei) 		5 / 10 ASP B 107
ARG B 112
GLN B 252
ASP B 255
LYS B 269
 MG  B1369 (-2.2A)
G76  B1368 (-2.8A)
G76  B1368 ( 4.0A)
MG  B1371 ( 3.0A)
G76  B1368 (-3.1A)
 1.18A 2qisA-5ahuB:
32.9		 2qisA-5ahuB:
33.15
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2QIS_A_RISA901_1
(FARNESYL
PYROPHOSPHATE
SYNTHETASE)		 5ahu FARNESYL
PYROPHOSPHATE
SYNTHASE
(Trypanosoma
brucei) 		9 / 10 LEU B 100
ASP B 103
ASP B 107
ARG B 112
GLN B 172
LYS B 212
GLN B 252
ASP B 255
LYS B 269
 None
MG  B1370 (-2.5A)
MG  B1369 (-2.2A)
G76  B1368 (-2.8A)
G76  B1368 ( 4.1A)
G76  B1368 (-2.8A)
G76  B1368 ( 4.0A)
MG  B1371 ( 3.0A)
G76  B1368 (-3.1A)
 0.48A 2qisA-5ahuB:
32.9		 2qisA-5ahuB:
33.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EZ3_A_ZOLA397_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE, PUTATIVE)		 5ahu FARNESYL
PYROPHOSPHATE
SYNTHASE
(Trypanosoma
brucei) 		9 / 9 ASP B 103
ASP B 107
ARG B 112
GLN B 172
LYS B 212
THR B 213
GLN B 252
ASP B 255
LYS B 269
 MG  B1370 (-2.5A)
MG  B1369 (-2.2A)
G76  B1368 (-2.8A)
G76  B1368 ( 4.1A)
G76  B1368 (-2.8A)
G76  B1368 (-4.2A)
G76  B1368 ( 4.0A)
MG  B1371 ( 3.0A)
G76  B1368 (-3.1A)
 0.66A 3ez3A-5ahuB:
32.9		 3ez3A-5ahuB:
25.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EZ3_B_ZOLB397_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE, PUTATIVE)		 5ahu FARNESYL
PYROPHOSPHATE
SYNTHASE
(Trypanosoma
brucei) 		9 / 9 ASP B 103
ASP B 107
ARG B 112
GLN B 172
LYS B 212
THR B 213
GLN B 252
ASP B 255
LYS B 269
 MG  B1370 (-2.5A)
MG  B1369 (-2.2A)
G76  B1368 (-2.8A)
G76  B1368 ( 4.1A)
G76  B1368 (-2.8A)
G76  B1368 (-4.2A)
G76  B1368 ( 4.0A)
MG  B1371 ( 3.0A)
G76  B1368 (-3.1A)
 0.55A 3ez3B-5ahuB:
23.5		 3ez3B-5ahuB:
25.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EZ3_C_ZOLC397_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE, PUTATIVE)		 5ahu FARNESYL
PYROPHOSPHATE
SYNTHASE
(Trypanosoma
brucei) 		8 / 9 ASP B 103
ASP B 107
ARG B 112
GLN B 172
LYS B 212
THR B 213
ASP B 255
LYS B 269
 MG  B1370 (-2.5A)
MG  B1369 (-2.2A)
G76  B1368 (-2.8A)
G76  B1368 ( 4.1A)
G76  B1368 (-2.8A)
G76  B1368 (-4.2A)
MG  B1371 ( 3.0A)
G76  B1368 (-3.1A)
 0.67A 3ez3C-5ahuB:
32.9		 3ez3C-5ahuB:
25.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EZ3_C_ZOLC397_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE, PUTATIVE)		 5ahu FARNESYL
PYROPHOSPHATE
SYNTHASE
(Trypanosoma
brucei) 		8 / 9 ASP B 103
ASP B 107
ARG B 112
LYS B 212
THR B 213
GLN B 252
ASP B 255
LYS B 269
 MG  B1370 (-2.5A)
MG  B1369 (-2.2A)
G76  B1368 (-2.8A)
G76  B1368 (-2.8A)
G76  B1368 (-4.2A)
G76  B1368 ( 4.0A)
MG  B1371 ( 3.0A)
G76  B1368 (-3.1A)
 0.48A 3ez3C-5ahuB:
32.9		 3ez3C-5ahuB:
25.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EZ3_D_ZOLD397_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE, PUTATIVE)		 5ahu FARNESYL
PYROPHOSPHATE
SYNTHASE
(Trypanosoma
brucei) 		10 / 10 LEU B 100
ASP B 103
ASP B 107
ARG B 112
GLN B 172
LYS B 212
THR B 213
GLN B 252
ASP B 255
LYS B 269
 None
MG  B1370 (-2.5A)
MG  B1369 (-2.2A)
G76  B1368 (-2.8A)
G76  B1368 ( 4.1A)
G76  B1368 (-2.8A)
G76  B1368 (-4.2A)
G76  B1368 ( 4.0A)
MG  B1371 ( 3.0A)
G76  B1368 (-3.1A)
 0.54A 3ez3D-5ahuB:
32.5		 3ez3D-5ahuB:
25.94
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3IBA_A_ZOLA901_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 5ahu FARNESYL
PYROPHOSPHATE
SYNTHASE
(Trypanosoma
brucei) 		10 / 10 ASP B 103
ASP B 107
ARG B 112
GLN B 172
LYS B 212
THR B 213
TYR B 216
GLN B 252
ASP B 255
LYS B 269
 MG  B1370 (-2.5A)
MG  B1369 (-2.2A)
G76  B1368 (-2.8A)
G76  B1368 ( 4.1A)
G76  B1368 (-2.8A)
G76  B1368 (-4.2A)
None
G76  B1368 ( 4.0A)
MG  B1371 ( 3.0A)
G76  B1368 (-3.1A)
 0.61A 3ibaA-5ahuB:
9.2		 3ibaA-5ahuB:
73.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LDW_A_ZOLA397_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 5ahu FARNESYL
PYROPHOSPHATE
SYNTHASE
(Trypanosoma
brucei) 		8 / 9 ASP B 103
ASP B 107
ARG B 112
GLN B 172
LYS B 212
GLN B 252
ASP B 255
LYS B 269
 MG  B1370 (-2.5A)
MG  B1369 (-2.2A)
G76  B1368 (-2.8A)
G76  B1368 ( 4.1A)
G76  B1368 (-2.8A)
G76  B1368 ( 4.0A)
MG  B1371 ( 3.0A)
G76  B1368 (-3.1A)
 0.71A 3ldwA-5ahuB:
32.8		 3ldwA-5ahuB:
25.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LDW_A_ZOLA397_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 5ahu FARNESYL
PYROPHOSPHATE
SYNTHASE
(Trypanosoma
brucei) 		8 / 9 ASP B 103
ASP B 107
ARG B 112
LYS B 212
THR B 213
GLN B 252
ASP B 255
LYS B 269
 MG  B1370 (-2.5A)
MG  B1369 (-2.2A)
G76  B1368 (-2.8A)
G76  B1368 (-2.8A)
G76  B1368 (-4.2A)
G76  B1368 ( 4.0A)
MG  B1371 ( 3.0A)
G76  B1368 (-3.1A)
 0.49A 3ldwA-5ahuB:
32.8		 3ldwA-5ahuB:
25.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LDW_B_ZOLB397_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 5ahu FARNESYL
PYROPHOSPHATE
SYNTHASE
(Trypanosoma
brucei) 		9 / 9 ASP B 103
ASP B 107
ARG B 112
GLN B 172
LYS B 212
THR B 213
GLN B 252
ASP B 255
LYS B 269
 MG  B1370 (-2.5A)
MG  B1369 (-2.2A)
G76  B1368 (-2.8A)
G76  B1368 ( 4.1A)
G76  B1368 (-2.8A)
G76  B1368 (-4.2A)
G76  B1368 ( 4.0A)
MG  B1371 ( 3.0A)
G76  B1368 (-3.1A)
 0.57A 3ldwB-5ahuB:
32.6		 3ldwB-5ahuB:
25.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LDW_C_ZOLC397_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 5ahu FARNESYL
PYROPHOSPHATE
SYNTHASE
(Trypanosoma
brucei) 		9 / 9 ASP B 103
ASP B 107
ARG B 112
GLN B 172
LYS B 212
THR B 213
GLN B 252
ASP B 255
LYS B 269
 MG  B1370 (-2.5A)
MG  B1369 (-2.2A)
G76  B1368 (-2.8A)
G76  B1368 ( 4.1A)
G76  B1368 (-2.8A)
G76  B1368 (-4.2A)
G76  B1368 ( 4.0A)
MG  B1371 ( 3.0A)
G76  B1368 (-3.1A)
 0.66A 3ldwC-5ahuB:
32.8		 3ldwC-5ahuB:
25.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LDW_D_ZOLD397_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 5ahu FARNESYL
PYROPHOSPHATE
SYNTHASE
(Trypanosoma
brucei) 		9 / 9 ASP B 103
ASP B 107
ARG B 112
GLN B 172
LYS B 212
THR B 213
GLN B 252
ASP B 255
LYS B 269
 MG  B1370 (-2.5A)
MG  B1369 (-2.2A)
G76  B1368 (-2.8A)
G76  B1368 ( 4.1A)
G76  B1368 (-2.8A)
G76  B1368 (-4.2A)
G76  B1368 ( 4.0A)
MG  B1371 ( 3.0A)
G76  B1368 (-3.1A)
 0.57A 3ldwD-5ahuB:
32.6		 3ldwD-5ahuB:
25.94
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3N45_F_ZOLF354_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 5ahu FARNESYL
PYROPHOSPHATE
SYNTHASE
(Trypanosoma
brucei) 		11 / 11 LEU B 100
ASP B 103
ASP B 107
ARG B 112
GLN B 172
LYS B 212
THR B 213
TYR B 216
GLN B 252
ASP B 255
LYS B 269
 None
MG  B1370 (-2.5A)
MG  B1369 (-2.2A)
G76  B1368 (-2.8A)
G76  B1368 ( 4.1A)
G76  B1368 (-2.8A)
G76  B1368 (-4.2A)
None
G76  B1368 ( 4.0A)
MG  B1371 ( 3.0A)
G76  B1368 (-3.1A)
 0.49A 3n45F-5ahuB:
16.6		 3n45F-5ahuB:
33.79
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3N46_F_ZOLF354_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 5ahu FARNESYL
PYROPHOSPHATE
SYNTHASE
(Trypanosoma
brucei) 		10 / 10 LEU B 100
ASP B 103
ASP B 107
ARG B 112
GLN B 172
LYS B 212
THR B 213
GLN B 252
ASP B 255
LYS B 269
 None
MG  B1370 (-2.5A)
MG  B1369 (-2.2A)
G76  B1368 (-2.8A)
G76  B1368 ( 4.1A)
G76  B1368 (-2.8A)
G76  B1368 (-4.2A)
G76  B1368 ( 4.0A)
MG  B1371 ( 3.0A)
G76  B1368 (-3.1A)
 0.53A 3n46F-5ahuB:
15.0		 3n46F-5ahuB:
33.79
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4KFA_A_ZOLA404_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 5ahu FARNESYL
PYROPHOSPHATE
SYNTHASE
(Trypanosoma
brucei) 		9 / 9 LEU B 100
ASP B 103
ASP B 107
ARG B 112
GLN B 172
LYS B 212
GLN B 252
ASP B 255
LYS B 269
 None
MG  B1370 (-2.5A)
MG  B1369 (-2.2A)
G76  B1368 (-2.8A)
G76  B1368 ( 4.1A)
G76  B1368 (-2.8A)
G76  B1368 ( 4.0A)
MG  B1371 ( 3.0A)
G76  B1368 (-3.1A)
 0.54A 4kfaA-5ahuB:
16.1		 4kfaA-5ahuB:
30.79
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4KPD_A_RISA405_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 5ahu FARNESYL
PYROPHOSPHATE
SYNTHASE
(Trypanosoma
brucei) 		10 / 10 LEU B 100
ASP B 103
ASP B 107
ARG B 112
GLN B 172
LYS B 212
THR B 213
GLN B 252
ASP B 255
LYS B 269
 None
MG  B1370 (-2.5A)
MG  B1369 (-2.2A)
G76  B1368 (-2.8A)
G76  B1368 ( 4.1A)
G76  B1368 (-2.8A)
G76  B1368 (-4.2A)
G76  B1368 ( 4.0A)
MG  B1371 ( 3.0A)
G76  B1368 (-3.1A)
 0.48A 4kpdA-5ahuB:
33.8		 4kpdA-5ahuB:
30.79
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4KPJ_A_210A901_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 5ahu FARNESYL
PYROPHOSPHATE
SYNTHASE
(Trypanosoma
brucei) 		5 / 9 ASP B 107
ARG B 112
GLN B 252
ASP B 255
LYS B 269
 MG  B1369 (-2.2A)
G76  B1368 (-2.8A)
G76  B1368 ( 4.0A)
MG  B1371 ( 3.0A)
G76  B1368 (-3.1A)
 1.23A 4kpjA-5ahuB:
16.4		 4kpjA-5ahuB:
30.79
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4KPJ_A_210A901_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 5ahu FARNESYL
PYROPHOSPHATE
SYNTHASE
(Trypanosoma
brucei) 		9 / 9 LEU B 100
ASP B 103
ASP B 107
ARG B 112
LYS B 212
THR B 213
GLN B 252
ASP B 255
LYS B 269
 None
MG  B1370 (-2.5A)
MG  B1369 (-2.2A)
G76  B1368 (-2.8A)
G76  B1368 (-2.8A)
G76  B1368 (-4.2A)
G76  B1368 ( 4.0A)
MG  B1371 ( 3.0A)
G76  B1368 (-3.1A)
 0.32A 4kpjA-5ahuB:
16.4		 4kpjA-5ahuB:
30.79
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4KQ5_A_ZOLA404_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 5ahu FARNESYL
PYROPHOSPHATE
SYNTHASE
(Trypanosoma
brucei) 		10 / 10 LEU B 100
ASP B 103
ASP B 107
ARG B 112
GLN B 172
LYS B 212
THR B 213
GLN B 252
ASP B 255
LYS B 269
 None
MG  B1370 (-2.5A)
MG  B1369 (-2.2A)
G76  B1368 (-2.8A)
G76  B1368 ( 4.1A)
G76  B1368 (-2.8A)
G76  B1368 (-4.2A)
G76  B1368 ( 4.0A)
MG  B1371 ( 3.0A)
G76  B1368 (-3.1A)
 0.54A 4kq5A-5ahuB:
16.6		 4kq5A-5ahuB:
30.79
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4KQS_A_RISA405_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 5ahu FARNESYL
PYROPHOSPHATE
SYNTHASE
(Trypanosoma
brucei) 		5 / 10 ASP B 107
ARG B 112
GLN B 252
ASP B 255
LYS B 269
 MG  B1369 (-2.2A)
G76  B1368 (-2.8A)
G76  B1368 ( 4.0A)
MG  B1371 ( 3.0A)
G76  B1368 (-3.1A)
 1.20A 4kqsA-5ahuB:
33.7		 4kqsA-5ahuB:
30.79
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4KQS_A_RISA405_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 5ahu FARNESYL
PYROPHOSPHATE
SYNTHASE
(Trypanosoma
brucei) 		10 / 10 LEU B 100
ASP B 103
ASP B 107
ARG B 112
GLN B 172
LYS B 212
THR B 213
GLN B 252
ASP B 255
LYS B 269
 None
MG  B1370 (-2.5A)
MG  B1369 (-2.2A)
G76  B1368 (-2.8A)
G76  B1368 ( 4.1A)
G76  B1368 (-2.8A)
G76  B1368 (-4.2A)
G76  B1368 ( 4.0A)
MG  B1371 ( 3.0A)
G76  B1368 (-3.1A)
 0.47A 4kqsA-5ahuB:
33.7		 4kqsA-5ahuB:
30.79
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4N9U_A_RISA404_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 5ahu FARNESYL
PYROPHOSPHATE
SYNTHASE
(Trypanosoma
brucei) 		5 / 10 ASP B 107
ARG B 112
GLN B 252
ASP B 255
LYS B 269
 MG  B1369 (-2.2A)
G76  B1368 (-2.8A)
G76  B1368 ( 4.0A)
MG  B1371 ( 3.0A)
G76  B1368 (-3.1A)
 1.20A 4n9uA-5ahuB:
15.9		 4n9uA-5ahuB:
30.79
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4N9U_A_RISA404_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 5ahu FARNESYL
PYROPHOSPHATE
SYNTHASE
(Trypanosoma
brucei) 		9 / 10 LEU B 100
ASP B 103
ASP B 107
ARG B 112
GLN B 172
THR B 213
GLN B 252
ASP B 255
LYS B 269
 None
MG  B1370 (-2.5A)
MG  B1369 (-2.2A)
G76  B1368 (-2.8A)
G76  B1368 ( 4.1A)
G76  B1368 (-4.2A)
G76  B1368 ( 4.0A)
MG  B1371 ( 3.0A)
G76  B1368 (-3.1A)
 0.53A 4n9uA-5ahuB:
15.9		 4n9uA-5ahuB:
30.79
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4N9U_A_RISA404_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 5ahu FARNESYL
PYROPHOSPHATE
SYNTHASE
(Trypanosoma
brucei) 		9 / 10 LEU B 100
ASP B 103
ASP B 107
ARG B 112
THR B 168
THR B 213
GLN B 252
ASP B 255
LYS B 269
 None
MG  B1370 (-2.5A)
MG  B1369 (-2.2A)
G76  B1368 (-2.8A)
None
G76  B1368 (-4.2A)
G76  B1368 ( 4.0A)
MG  B1371 ( 3.0A)
G76  B1368 (-3.1A)
 0.45A 4n9uA-5ahuB:
15.9		 4n9uA-5ahuB:
30.79
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4N9U_A_RISA404_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 5ahu FARNESYL
PYROPHOSPHATE
SYNTHASE
(Trypanosoma
brucei) 		5 / 10 LEU B 100
ASP B 103
ASP B 107
ARG B 112
THR B 213
 None
MG  B1370 (-2.5A)
MG  B1369 (-2.2A)
G76  B1368 (-2.8A)
G76  B1368 (-4.2A)
 1.22A 4n9uA-5ahuB:
15.9		 4n9uA-5ahuB:
30.79
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4NG6_A_RISA405_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 5ahu FARNESYL
PYROPHOSPHATE
SYNTHASE
(Trypanosoma
brucei) 		5 / 12 ASP B 107
ARG B 112
GLN B 252
ASP B 255
LYS B 269
 MG  B1369 (-2.2A)
G76  B1368 (-2.8A)
G76  B1368 ( 4.0A)
MG  B1371 ( 3.0A)
G76  B1368 (-3.1A)
 1.20A 4ng6A-5ahuB:
18.6		 4ng6A-5ahuB:
30.79
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4NG6_A_RISA405_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 5ahu FARNESYL
PYROPHOSPHATE
SYNTHASE
(Trypanosoma
brucei) 		11 / 12 LEU B 100
ASP B 103
ASP B 107
ARG B 112
THR B 168
GLN B 172
THR B 213
TYR B 216
GLN B 252
ASP B 255
LYS B 269
 None
MG  B1370 (-2.5A)
MG  B1369 (-2.2A)
G76  B1368 (-2.8A)
None
G76  B1368 ( 4.1A)
G76  B1368 (-4.2A)
None
G76  B1368 ( 4.0A)
MG  B1371 ( 3.0A)
G76  B1368 (-3.1A)
 0.53A 4ng6A-5ahuB:
18.6		 4ng6A-5ahuB:
30.79
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4NKE_A_RISA404_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 5ahu FARNESYL
PYROPHOSPHATE
SYNTHASE
(Trypanosoma
brucei) 		5 / 10 ASP B 107
ARG B 112
GLN B 252
ASP B 255
LYS B 269
 MG  B1369 (-2.2A)
G76  B1368 (-2.8A)
G76  B1368 ( 4.0A)
MG  B1371 ( 3.0A)
G76  B1368 (-3.1A)
 1.23A 4nkeA-5ahuB:
33.1		 4nkeA-5ahuB:
30.79
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4NKE_A_RISA404_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 5ahu FARNESYL
PYROPHOSPHATE
SYNTHASE
(Trypanosoma
brucei) 		10 / 10 LEU B 100
ASP B 103
ASP B 107
ARG B 112
GLN B 172
LYS B 212
THR B 213
GLN B 252
ASP B 255
LYS B 269
 None
MG  B1370 (-2.5A)
MG  B1369 (-2.2A)
G76  B1368 (-2.8A)
G76  B1368 ( 4.1A)
G76  B1368 (-2.8A)
G76  B1368 (-4.2A)
G76  B1368 ( 4.0A)
MG  B1371 ( 3.0A)
G76  B1368 (-3.1A)
 0.54A 4nkeA-5ahuB:
33.1		 4nkeA-5ahuB:
30.79
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4NKF_A_210A404_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 5ahu FARNESYL
PYROPHOSPHATE
SYNTHASE
(Trypanosoma
brucei) 		5 / 9 ASP B 107
ARG B 112
GLN B 252
ASP B 255
LYS B 269
 MG  B1369 (-2.2A)
G76  B1368 (-2.8A)
G76  B1368 ( 4.0A)
MG  B1371 ( 3.0A)
G76  B1368 (-3.1A)
 1.23A 4nkfA-5ahuB:
16.6		 4nkfA-5ahuB:
30.79
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4NKF_A_210A404_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 5ahu FARNESYL
PYROPHOSPHATE
SYNTHASE
(Trypanosoma
brucei) 		9 / 9 LEU B 100
ASP B 103
ASP B 107
ARG B 112
LYS B 212
THR B 213
GLN B 252
ASP B 255
LYS B 269
 None
MG  B1370 (-2.5A)
MG  B1369 (-2.2A)
G76  B1368 (-2.8A)
G76  B1368 (-2.8A)
G76  B1368 (-4.2A)
G76  B1368 ( 4.0A)
MG  B1371 ( 3.0A)
G76  B1368 (-3.1A)
 0.36A 4nkfA-5ahuB:
16.6		 4nkfA-5ahuB:
30.79
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4NUA_A_RISA901_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 5ahu FARNESYL
PYROPHOSPHATE
SYNTHASE
(Trypanosoma
brucei) 		5 / 10 ASP B 107
ARG B 112
GLN B 252
ASP B 255
LYS B 269
 MG  B1369 (-2.2A)
G76  B1368 (-2.8A)
G76  B1368 ( 4.0A)
MG  B1371 ( 3.0A)
G76  B1368 (-3.1A)
 1.29A 4nuaA-5ahuB:
12.3		 4nuaA-5ahuB:
30.79
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4NUA_A_RISA901_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 5ahu FARNESYL
PYROPHOSPHATE
SYNTHASE
(Trypanosoma
brucei) 		10 / 10 LEU B 100
ASP B 103
ASP B 107
ARG B 112
GLN B 172
LYS B 212
THR B 213
GLN B 252
ASP B 255
LYS B 269
 None
MG  B1370 (-2.5A)
MG  B1369 (-2.2A)
G76  B1368 (-2.8A)
G76  B1368 ( 4.1A)
G76  B1368 (-2.8A)
G76  B1368 (-4.2A)
G76  B1368 ( 4.0A)
MG  B1371 ( 3.0A)
G76  B1368 (-3.1A)
 0.58A 4nuaA-5ahuB:
12.3		 4nuaA-5ahuB:
30.79
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4OGU_A_210A405_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 5ahu FARNESYL
PYROPHOSPHATE
SYNTHASE
(Trypanosoma
brucei) 		5 / 9 ASP B 107
ARG B 112
GLN B 252
ASP B 255
LYS B 269
 MG  B1369 (-2.2A)
G76  B1368 (-2.8A)
G76  B1368 ( 4.0A)
MG  B1371 ( 3.0A)
G76  B1368 (-3.1A)
 1.22A 4oguA-5ahuB:
17.5		 4oguA-5ahuB:
30.79
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4OGU_A_210A405_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 5ahu FARNESYL
PYROPHOSPHATE
SYNTHASE
(Trypanosoma
brucei) 		9 / 9 LEU B 100
ASP B 103
ASP B 107
ARG B 112
LYS B 212
THR B 213
GLN B 252
ASP B 255
LYS B 269
 None
MG  B1370 (-2.5A)
MG  B1369 (-2.2A)
G76  B1368 (-2.8A)
G76  B1368 (-2.8A)
G76  B1368 (-4.2A)
G76  B1368 ( 4.0A)
MG  B1371 ( 3.0A)
G76  B1368 (-3.1A)
 0.32A 4oguA-5ahuB:
17.5		 4oguA-5ahuB:
30.79
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4P0V_A_ZOLA401_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 5ahu FARNESYL
PYROPHOSPHATE
SYNTHASE
(Trypanosoma
brucei) 		9 / 9 ASP B 103
ASP B 107
ARG B 112
GLN B 172
LYS B 212
THR B 213
GLN B 252
ASP B 255
LYS B 269
 MG  B1370 (-2.5A)
MG  B1369 (-2.2A)
G76  B1368 (-2.8A)
G76  B1368 ( 4.1A)
G76  B1368 (-2.8A)
G76  B1368 (-4.2A)
G76  B1368 ( 4.0A)
MG  B1371 ( 3.0A)
G76  B1368 (-3.1A)
 0.46A 4p0vA-5ahuB:
16.6		 4p0vA-5ahuB:
33.79
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4P0W_A_ZOLA501_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 5ahu FARNESYL
PYROPHOSPHATE
SYNTHASE
(Trypanosoma
brucei) 		5 / 11 LEU B 100
ARG B 112
THR B 217
TYR B 216
LYS B 269
 None
G76  B1368 (-2.8A)
None
None
G76  B1368 (-3.1A)
 1.48A 4p0wA-5ahuB:
17.6		 4p0wA-5ahuB:
33.79
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4P0W_A_ZOLA501_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 5ahu FARNESYL
PYROPHOSPHATE
SYNTHASE
(Trypanosoma
brucei) 		11 / 11 LEU B 100
ASP B 103
ASP B 107
ARG B 112
GLN B 172
LYS B 212
THR B 213
TYR B 216
GLN B 252
ASP B 255
LYS B 269
 None
MG  B1370 (-2.5A)
MG  B1369 (-2.2A)
G76  B1368 (-2.8A)
G76  B1368 ( 4.1A)
G76  B1368 (-2.8A)
G76  B1368 (-4.2A)
None
G76  B1368 ( 4.0A)
MG  B1371 ( 3.0A)
G76  B1368 (-3.1A)
 0.45A 4p0wA-5ahuB:
17.6		 4p0wA-5ahuB:
33.79
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4Q23_A_RISA901_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 5ahu FARNESYL
PYROPHOSPHATE
SYNTHASE
(Trypanosoma
brucei) 		5 / 10 ASP B 107
ARG B 112
GLN B 252
ASP B 255
LYS B 269
 MG  B1369 (-2.2A)
G76  B1368 (-2.8A)
G76  B1368 ( 4.0A)
MG  B1371 ( 3.0A)
G76  B1368 (-3.1A)
 1.17A 4q23A-5ahuB:
11.9		 4q23A-5ahuB:
30.79
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4Q23_A_RISA901_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 5ahu FARNESYL
PYROPHOSPHATE
SYNTHASE
(Trypanosoma
brucei) 		10 / 10 LEU B 100
ASP B 103
ASP B 107
ARG B 112
GLN B 172
LYS B 212
TYR B 216
GLN B 252
ASP B 255
LYS B 269
 None
MG  B1370 (-2.5A)
MG  B1369 (-2.2A)
G76  B1368 (-2.8A)
G76  B1368 ( 4.1A)
G76  B1368 (-2.8A)
None
G76  B1368 ( 4.0A)
MG  B1371 ( 3.0A)
G76  B1368 (-3.1A)
 0.47A 4q23A-5ahuB:
11.9		 4q23A-5ahuB:
30.79
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4RXD_A_RISA1404_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 5ahu FARNESYL
PYROPHOSPHATE
SYNTHASE
(Trypanosoma
brucei) 		5 / 10 ASP B 107
ARG B 112
GLN B 252
ASP B 255
LYS B 269
 MG  B1369 (-2.2A)
G76  B1368 (-2.8A)
G76  B1368 ( 4.0A)
MG  B1371 ( 3.0A)
G76  B1368 (-3.1A)
 1.20A 4rxdA-5ahuB:
41.7		 4rxdA-5ahuB:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4RXD_A_RISA1404_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 5ahu FARNESYL
PYROPHOSPHATE
SYNTHASE
(Trypanosoma
brucei) 		10 / 10 LEU B 100
ASP B 103
ASP B 107
ARG B 112
GLN B 172
LYS B 212
THR B 213
GLN B 252
ASP B 255
LYS B 269
 None
MG  B1370 (-2.5A)
MG  B1369 (-2.2A)
G76  B1368 (-2.8A)
G76  B1368 ( 4.1A)
G76  B1368 (-2.8A)
G76  B1368 (-4.2A)
G76  B1368 ( 4.0A)
MG  B1371 ( 3.0A)
G76  B1368 (-3.1A)
 0.48A 4rxdA-5ahuB:
41.7		 4rxdA-5ahuB:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4RXD_B_RISB1504_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 5ahu FARNESYL
PYROPHOSPHATE
SYNTHASE
(Trypanosoma
brucei) 		5 / 10 ASP B 107
ARG B 112
GLN B 252
ASP B 255
LYS B 269
 MG  B1369 (-2.2A)
G76  B1368 (-2.8A)
G76  B1368 ( 4.0A)
MG  B1371 ( 3.0A)
G76  B1368 (-3.1A)
 1.19A 4rxdB-5ahuB:
19.8		 4rxdB-5ahuB:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4RXD_B_RISB1504_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 5ahu FARNESYL
PYROPHOSPHATE
SYNTHASE
(Trypanosoma
brucei) 		10 / 10 LEU B 100
ASP B 103
ASP B 107
ARG B 112
GLN B 172
LYS B 212
THR B 213
GLN B 252
ASP B 255
LYS B 269
 None
MG  B1370 (-2.5A)
MG  B1369 (-2.2A)
G76  B1368 (-2.8A)
G76  B1368 ( 4.1A)
G76  B1368 (-2.8A)
G76  B1368 (-4.2A)
G76  B1368 ( 4.0A)
MG  B1371 ( 3.0A)
G76  B1368 (-3.1A)
 0.47A 4rxdB-5ahuB:
19.8		 4rxdB-5ahuB:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4RXD_C_RISC1600_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 5ahu FARNESYL
PYROPHOSPHATE
SYNTHASE
(Trypanosoma
brucei) 		5 / 10 ASP B 107
ARG B 112
GLN B 252
ASP B 255
LYS B 269
 MG  B1369 (-2.2A)
G76  B1368 (-2.8A)
G76  B1368 ( 4.0A)
MG  B1371 ( 3.0A)
G76  B1368 (-3.1A)
 1.21A 4rxdC-5ahuB:
41.7		 4rxdC-5ahuB:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4RXD_C_RISC1600_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 5ahu FARNESYL
PYROPHOSPHATE
SYNTHASE
(Trypanosoma
brucei) 		10 / 10 LEU B 100
ASP B 103
ASP B 107
ARG B 112
GLN B 172
LYS B 212
THR B 213
GLN B 252
ASP B 255
LYS B 269
 None
MG  B1370 (-2.5A)
MG  B1369 (-2.2A)
G76  B1368 (-2.8A)
G76  B1368 ( 4.1A)
G76  B1368 (-2.8A)
G76  B1368 (-4.2A)
G76  B1368 ( 4.0A)
MG  B1371 ( 3.0A)
G76  B1368 (-3.1A)
 0.47A 4rxdC-5ahuB:
41.7		 4rxdC-5ahuB:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UMJ_A_BFQA1297_1
(GERANYLTRANSTRANSFER
ASE)		 5ahu FARNESYL
PYROPHOSPHATE
SYNTHASE
(Trypanosoma
brucei) 		6 / 8 LEU B 100
ASP B 103
ASP B 107
ARG B 112
GLN B 172
LYS B 212
 None
MG  B1370 (-2.5A)
MG  B1369 (-2.2A)
G76  B1368 (-2.8A)
G76  B1368 ( 4.1A)
G76  B1368 (-2.8A)
 0.61A 4umjA-5ahuB:
16.8		 4umjA-5ahuB:
23.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UMJ_B_BFQB1294_1
(GERANYLTRANSTRANSFER
ASE)		 5ahu FARNESYL
PYROPHOSPHATE
SYNTHASE
(Trypanosoma
brucei) 		7 / 9 LEU B 100
ASP B 103
ASP B 107
ARG B 112
GLN B 172
LYS B 212
THR B 213
 None
MG  B1370 (-2.5A)
MG  B1369 (-2.2A)
G76  B1368 (-2.8A)
G76  B1368 ( 4.1A)
G76  B1368 (-2.8A)
G76  B1368 (-4.2A)
 0.51A 4umjB-5ahuB:
9.4		 4umjB-5ahuB:
23.99
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5CG5_A_RISA400_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 5ahu FARNESYL
PYROPHOSPHATE
SYNTHASE
(Trypanosoma
brucei) 		5 / 12 ASP B 107
ARG B 112
GLN B 252
ASP B 255
LYS B 269
 MG  B1369 (-2.2A)
G76  B1368 (-2.8A)
G76  B1368 ( 4.0A)
MG  B1371 ( 3.0A)
G76  B1368 (-3.1A)
 1.21A 5cg5A-5ahuB:
16.7		 5cg5A-5ahuB:
33.79
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5CG5_A_RISA400_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 5ahu FARNESYL
PYROPHOSPHATE
SYNTHASE
(Trypanosoma
brucei) 		12 / 12 LEU B 100
ASP B 103
ASP B 107
ARG B 112
THR B 168
GLN B 172
LYS B 212
THR B 213
TYR B 216
GLN B 252
ASP B 255
LYS B 269
 None
MG  B1370 (-2.5A)
MG  B1369 (-2.2A)
G76  B1368 (-2.8A)
None
G76  B1368 ( 4.1A)
G76  B1368 (-2.8A)
G76  B1368 (-4.2A)
None
G76  B1368 ( 4.0A)
MG  B1371 ( 3.0A)
G76  B1368 (-3.1A)
 0.47A 5cg5A-5ahuB:
16.7		 5cg5A-5ahuB:
33.79
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5CG6_A_RISA404_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 5ahu FARNESYL
PYROPHOSPHATE
SYNTHASE
(Trypanosoma
brucei) 		5 / 12 ASP B 107
ARG B 112
GLN B 252
ASP B 255
LYS B 269
 MG  B1369 (-2.2A)
G76  B1368 (-2.8A)
G76  B1368 ( 4.0A)
MG  B1371 ( 3.0A)
G76  B1368 (-3.1A)
 1.18A 5cg6A-5ahuB:
16.8		 5cg6A-5ahuB:
33.79
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5CG6_A_RISA404_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 5ahu FARNESYL
PYROPHOSPHATE
SYNTHASE
(Trypanosoma
brucei) 		11 / 12 LEU B 100
ASP B 103
ASP B 107
ARG B 112
THR B 168
GLN B 172
LYS B 212
THR B 213
GLN B 252
ASP B 255
LYS B 269
 None
MG  B1370 (-2.5A)
MG  B1369 (-2.2A)
G76  B1368 (-2.8A)
None
G76  B1368 ( 4.1A)
G76  B1368 (-2.8A)
G76  B1368 (-4.2A)
G76  B1368 ( 4.0A)
MG  B1371 ( 3.0A)
G76  B1368 (-3.1A)
 0.47A 5cg6A-5ahuB:
16.8		 5cg6A-5ahuB:
33.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ERO_A_210A804_1
(FUSICOCCADIENE
SYNTHASE)		 5ahu FARNESYL
PYROPHOSPHATE
SYNTHASE
(Trypanosoma
brucei) 		6 / 9 LEU B 100
ASP B 103
ARG B 112
LYS B 212
GLN B 252
LYS B 269
 None
MG  B1370 (-2.5A)
G76  B1368 (-2.8A)
G76  B1368 (-2.8A)
G76  B1368 ( 4.0A)
G76  B1368 (-3.1A)
 1.22A 5eroA-5ahuB:
24.1		 5eroA-5ahuB:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ERO_A_210A804_1
(FUSICOCCADIENE
SYNTHASE)		 5ahu FARNESYL
PYROPHOSPHATE
SYNTHASE
(Trypanosoma
brucei) 		7 / 9 LEU B 100
ASP B 103
ASP B 107
ARG B 112
LYS B 212
GLN B 252
ASP B 255
 None
MG  B1370 (-2.5A)
MG  B1369 (-2.2A)
G76  B1368 (-2.8A)
G76  B1368 (-2.8A)
G76  B1368 ( 4.0A)
MG  B1371 ( 3.0A)
 0.55A 5eroA-5ahuB:
24.1		 5eroA-5ahuB:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ERO_B_210B804_1
(FUSICOCCADIENE
SYNTHASE)		 5ahu FARNESYL
PYROPHOSPHATE
SYNTHASE
(Trypanosoma
brucei) 		6 / 9 ASP B 103
ARG B 112
LYS B 212
GLN B 252
ASP B 256
LYS B 269
 MG  B1370 (-2.5A)
G76  B1368 (-2.8A)
G76  B1368 (-2.8A)
G76  B1368 ( 4.0A)
None
G76  B1368 (-3.1A)
 1.17A 5eroB-5ahuB:
23.5		 5eroB-5ahuB:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ERO_B_210B804_1
(FUSICOCCADIENE
SYNTHASE)		 5ahu FARNESYL
PYROPHOSPHATE
SYNTHASE
(Trypanosoma
brucei) 		7 / 9 ASP B 103
ASP B 107
ARG B 112
LYS B 212
GLN B 252
ASP B 255
ASP B 256
 MG  B1370 (-2.5A)
MG  B1369 (-2.2A)
G76  B1368 (-2.8A)
G76  B1368 (-2.8A)
G76  B1368 ( 4.0A)
MG  B1371 ( 3.0A)
None
 0.48A 5eroB-5ahuB:
23.5		 5eroB-5ahuB:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ERO_B_210B804_1
(FUSICOCCADIENE
SYNTHASE)		 5ahu FARNESYL
PYROPHOSPHATE
SYNTHASE
(Trypanosoma
brucei) 		5 / 9 ASP B 107
ARG B 112
GLN B 252
ASP B 255
ASP B 256
 MG  B1369 (-2.2A)
G76  B1368 (-2.8A)
G76  B1368 ( 4.0A)
MG  B1371 ( 3.0A)
None
 1.27A 5eroB-5ahuB:
23.5		 5eroB-5ahuB:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ERO_C_210C804_1
(FUSICOCCADIENE
SYNTHASE)		 5ahu FARNESYL
PYROPHOSPHATE
SYNTHASE
(Trypanosoma
brucei) 		8 / 10 ASP B 103
ASP B 104
ASP B 107
ARG B 112
LYS B 212
GLN B 252
ASP B 255
ASP B 256
 MG  B1370 (-2.5A)
G76  B1368 ( 4.7A)
MG  B1369 (-2.2A)
G76  B1368 (-2.8A)
G76  B1368 (-2.8A)
G76  B1368 ( 4.0A)
MG  B1371 ( 3.0A)
None
 0.55A 5eroC-5ahuB:
23.9		 5eroC-5ahuB:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ERO_C_210C804_1
(FUSICOCCADIENE
SYNTHASE)		 5ahu FARNESYL
PYROPHOSPHATE
SYNTHASE
(Trypanosoma
brucei) 		7 / 10 ASP B 103
ASP B 107
ARG B 112
LYS B 212
GLN B 252
ASP B 256
LYS B 269
 MG  B1370 (-2.5A)
MG  B1369 (-2.2A)
G76  B1368 (-2.8A)
G76  B1368 (-2.8A)
G76  B1368 ( 4.0A)
None
G76  B1368 (-3.1A)
 0.93A 5eroC-5ahuB:
23.9		 5eroC-5ahuB:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ERO_C_210C804_1
(FUSICOCCADIENE
SYNTHASE)		 5ahu FARNESYL
PYROPHOSPHATE
SYNTHASE
(Trypanosoma
brucei) 		5 / 10 ASP B 103
ASP B 107
LYS B 212
GLN B 252
ASP B 255
 MG  B1370 (-2.5A)
MG  B1369 (-2.2A)
G76  B1368 (-2.8A)
G76  B1368 ( 4.0A)
MG  B1371 ( 3.0A)
 1.49A 5eroC-5ahuB:
23.9		 5eroC-5ahuB:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ERO_C_210C804_1
(FUSICOCCADIENE
SYNTHASE)		 5ahu FARNESYL
PYROPHOSPHATE
SYNTHASE
(Trypanosoma
brucei) 		6 / 10 ASP B 107
ASP B 104
ARG B 112
GLN B 252
ASP B 255
ASP B 256
 MG  B1369 (-2.2A)
G76  B1368 ( 4.7A)
G76  B1368 (-2.8A)
G76  B1368 ( 4.0A)
MG  B1371 ( 3.0A)
None
 1.29A 5eroC-5ahuB:
23.9		 5eroC-5ahuB:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6G31_A_ZOLA401_0
(GERANYLGERANYL
PYROPHOSPHATE
SYNTHASE)		 5ahu FARNESYL
PYROPHOSPHATE
SYNTHASE
(Trypanosoma
brucei) 		6 / 7 ASP B 103
ASP B 107
ARG B 112
GLN B 172
LYS B 212
GLN B 252
 MG  B1370 (-2.5A)
MG  B1369 (-2.2A)
G76  B1368 (-2.8A)
G76  B1368 ( 4.1A)
G76  B1368 (-2.8A)
G76  B1368 ( 4.0A)
 1.03A 6g31A-5ahuB:
22.8		 6g31A-5ahuB:
13.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6G31_B_ZOLB401_0
(GERANYLGERANYL
PYROPHOSPHATE
SYNTHASE)		 5ahu FARNESYL
PYROPHOSPHATE
SYNTHASE
(Trypanosoma
brucei) 		5 / 6 ASP B 103
ASP B 107
ARG B 112
GLN B 172
GLN B 252
 MG  B1370 (-2.5A)
MG  B1369 (-2.2A)
G76  B1368 (-2.8A)
G76  B1368 ( 4.1A)
G76  B1368 ( 4.0A)
 0.76A 6g31B-5ahuB:
23.0		 6g31B-5ahuB:
13.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6G31_C_ZOLC401_0
(GERANYLGERANYL
PYROPHOSPHATE
SYNTHASE)		 5ahu FARNESYL
PYROPHOSPHATE
SYNTHASE
(Trypanosoma
brucei) 		5 / 5 ASP B 103
ASP B 107
ARG B 112
GLN B 172
LYS B 212
 MG  B1370 (-2.5A)
MG  B1369 (-2.2A)
G76  B1368 (-2.8A)
G76  B1368 ( 4.1A)
G76  B1368 (-2.8A)
 1.24A 6g31C-5ahuB:
23.1		 6g31C-5ahuB:
13.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6G31_D_ZOLD401_0
(GERANYLGERANYL
PYROPHOSPHATE
SYNTHASE)		 5ahu FARNESYL
PYROPHOSPHATE
SYNTHASE
(Trypanosoma
brucei) 		6 / 7 LEU B 100
ASP B 103
ASP B 107
ARG B 112
GLN B 172
GLN B 252
 None
MG  B1370 (-2.5A)
MG  B1369 (-2.2A)
G76  B1368 (-2.8A)
G76  B1368 ( 4.1A)
G76  B1368 ( 4.0A)
 0.65A 6g31D-5ahuB:
23.4		 6g31D-5ahuB:
13.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6G31_E_ZOLE401_0
(GERANYLGERANYL
PYROPHOSPHATE
SYNTHASE)		 5ahu FARNESYL
PYROPHOSPHATE
SYNTHASE
(Trypanosoma
brucei) 		4 / 4 LEU B 100
ASP B 103
ASP B 107
ARG B 112
 None
MG  B1370 (-2.5A)
MG  B1369 (-2.2A)
G76  B1368 (-2.8A)
 0.33A 6g31E-5ahuB:
18.2		 6g31E-5ahuB:
13.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6G31_F_ZOLF401_0
(GERANYLGERANYL
PYROPHOSPHATE
SYNTHASE)		 5ahu FARNESYL
PYROPHOSPHATE
SYNTHASE
(Trypanosoma
brucei) 		5 / 5 ASP B 103
ASP B 107
ARG B 112
GLN B 172
GLN B 252
 MG  B1370 (-2.5A)
MG  B1369 (-2.2A)
G76  B1368 (-2.8A)
G76  B1368 ( 4.1A)
G76  B1368 ( 4.0A)
 0.72A 6g31F-5ahuB:
23.2		 6g31F-5ahuB:
13.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6G31_G_ZOLG401_0
(GERANYLGERANYL
PYROPHOSPHATE
SYNTHASE)		 5ahu FARNESYL
PYROPHOSPHATE
SYNTHASE
(Trypanosoma
brucei) 		6 / 7 ASP B 103
ASP B 107
ARG B 112
GLN B 172
LYS B 212
GLN B 252
 MG  B1370 (-2.5A)
MG  B1369 (-2.2A)
G76  B1368 (-2.8A)
G76  B1368 ( 4.1A)
G76  B1368 (-2.8A)
G76  B1368 ( 4.0A)
 0.59A 6g31G-5ahuB:
21.9		 6g31G-5ahuB:
13.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6G31_H_ZOLH401_0
(GERANYLGERANYL
PYROPHOSPHATE
SYNTHASE)		 5ahu FARNESYL
PYROPHOSPHATE
SYNTHASE
(Trypanosoma
brucei) 		4 / 5 ASP B 103
ASP B 107
GLN B 172
GLN B 252
 MG  B1370 (-2.5A)
MG  B1369 (-2.2A)
G76  B1368 ( 4.1A)
G76  B1368 ( 4.0A)
 0.70A 6g31H-5ahuB:
22.6		 6g31H-5ahuB:
13.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6G31_H_ZOLH401_0
(GERANYLGERANYL
PYROPHOSPHATE
SYNTHASE)		 5ahu FARNESYL
PYROPHOSPHATE
SYNTHASE
(Trypanosoma
brucei) 		4 / 5 ASP B 103
ASP B 107
GLN B 172
LYS B 278
 MG  B1370 (-2.5A)
MG  B1369 (-2.2A)
G76  B1368 ( 4.1A)
MG  B1369 (-3.6A)
 1.26A 6g31H-5ahuB:
22.6		 6g31H-5ahuB:
13.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6G31_I_ZOLI401_0
(GERANYLGERANYL
PYROPHOSPHATE
SYNTHASE)		 5ahu FARNESYL
PYROPHOSPHATE
SYNTHASE
(Trypanosoma
brucei) 		4 / 4 ASP B 103
ASP B 107
LYS B 212
GLN B 252
 MG  B1370 (-2.5A)
MG  B1369 (-2.2A)
G76  B1368 (-2.8A)
G76  B1368 ( 4.0A)
 0.88A 6g31I-5ahuB:
21.9		 6g31I-5ahuB:
13.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6G31_J_ZOLJ401_0
(GERANYLGERANYL
PYROPHOSPHATE
SYNTHASE)		 5ahu FARNESYL
PYROPHOSPHATE
SYNTHASE
(Trypanosoma
brucei) 		6 / 6 LEU B 100
ASP B 103
ASP B 107
ARG B 112
GLN B 172
GLN B 252
 None
MG  B1370 (-2.5A)
MG  B1369 (-2.2A)
G76  B1368 (-2.8A)
G76  B1368 ( 4.1A)
G76  B1368 ( 4.0A)
 0.95A 6g31J-5ahuB:
23.3		 6g31J-5ahuB:
13.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6G31_K_ZOLK401_0
(GERANYLGERANYL
PYROPHOSPHATE
SYNTHASE)		 5ahu FARNESYL
PYROPHOSPHATE
SYNTHASE
(Trypanosoma
brucei) 		4 / 4 ASP B 103
ASP B 107
ARG B 112
GLN B 172
 MG  B1370 (-2.5A)
MG  B1369 (-2.2A)
G76  B1368 (-2.8A)
G76  B1368 ( 4.1A)
 0.62A 6g31K-5ahuB:
20.9		 6g31K-5ahuB:
13.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6G31_L_ZOLL401_0
(GERANYLGERANYL
PYROPHOSPHATE
SYNTHASE)		 5ahu FARNESYL
PYROPHOSPHATE
SYNTHASE
(Trypanosoma
brucei) 		6 / 6 ASP B 103
ASP B 107
ARG B 112
GLN B 172
GLN B 252
LYS B 278
 MG  B1370 (-2.5A)
MG  B1369 (-2.2A)
G76  B1368 (-2.8A)
G76  B1368 ( 4.1A)
G76  B1368 ( 4.0A)
MG  B1369 (-3.6A)
 1.12A 6g31L-5ahuB:
22.7		 6g31L-5ahuB:
13.60