SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'G6Q'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LIN_A_TFPA154_1
(CALMODULIN)		 2j6h GLUCOSAMINE-FRUCTOSE
-6-PHOSPHATE
AMINOTRANSFERASE
(Escherichia
coli) 		4 / 7 LEU A 601
GLU A 488
LEU A 484
GLU A 481
 None
G6Q  A1610 (-2.5A)
None
None
 1.03A 1linA-2j6hA:
undetectable		 1linA-2j6hA:
14.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LQT_A_ACTA1869_0
(FPRA)		 4hjh PHOSPHOMANNOMUTASE
(Brucella
melitensis) 		4 / 4 ASP A 214
HIS A 105
ARG A 445
GLU A 443
 None
SEP  A 104 (-3.7A)
G6Q  A 544 (-4.0A)
None
 1.13A 1lqtA-4hjhA:
undetectable		 1lqtA-4hjhA:
25.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PJ7_A_FFOA2887_1
(N,N-DIMETHYLGLYCINE
OXIDASE)		 4hjh PHOSPHOMANNOMUTASE
(Brucella
melitensis) 		3 / 3 ASP A 421
THR A 281
GLU A 216
 None
EDO  A 548 (-4.6A)
G6Q  A 544 (-4.3A)
 0.77A 1pj7A-4hjhA:
2.9		 1pj7A-4hjhA:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K9F_F_LFXF0_1
(DNA TOPOISOMERASE 4
SUBUNIT A
DNA TOPOISOMERASE 4
SUBUNIT B)		 2j6h GLUCOSAMINE-FRUCTOSE
-6-PHOSPHATE
AMINOTRANSFERASE
(Escherichia
coli) 		4 / 5 SER A 604
ARG A  26
ARG A 173
GLU A 208
 G6Q  A1610 ( 4.9A)
None
None
None
 1.25A 3k9fA-2j6hA:
undetectable
3k9fB-2j6hA:
undetectable
3k9fC-2j6hA:
3.4		 3k9fA-2j6hA:
22.17
3k9fB-2j6hA:
22.17
3k9fC-2j6hA:
17.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_D_TFPD201_1
(PROTEIN S100-A4)		 3ujh GLUCOSE-6-PHOSPHATE
ISOMERASE
(Toxoplasma
gondii) 		4 / 8 GLY A 157
CYH A 248
PHE A 247
PHE A 216
 G6Q  A 571 ( 3.3A)
None
None
None
 0.89A 3ko0D-3ujhA:
1.8
3ko0E-3ujhA:
1.9		 3ko0D-3ujhA:
9.95
3ko0E-3ujhA:
9.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_J_TFPJ201_1
(PROTEIN S100-A4)		 3ujh GLUCOSE-6-PHOSPHATE
ISOMERASE
(Toxoplasma
gondii) 		4 / 8 PHE A 216
GLY A 157
CYH A 248
PHE A 247
 None
G6Q  A 571 ( 3.3A)
None
None
 0.92A 3ko0B-3ujhA:
2.0
3ko0J-3ujhA:
1.7		 3ko0B-3ujhA:
9.95
3ko0J-3ujhA:
9.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_L_TFPL201_1
(PROTEIN S100-A4)		 3ujh GLUCOSE-6-PHOSPHATE
ISOMERASE
(Toxoplasma
gondii) 		4 / 7 GLY A 157
CYH A 248
PHE A 247
PHE A 216
 G6Q  A 571 ( 3.3A)
None
None
None
 0.89A 3ko0L-3ujhA:
1.9
3ko0N-3ujhA:
2.1		 3ko0L-3ujhA:
9.95
3ko0N-3ujhA:
9.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_M_TFPM201_1
(PROTEIN S100-A4)		 3ujh GLUCOSE-6-PHOSPHATE
ISOMERASE
(Toxoplasma
gondii) 		4 / 7 GLY A 157
CYH A 248
PHE A 247
PHE A 216
 G6Q  A 571 ( 3.3A)
None
None
None
 0.94A 3ko0M-3ujhA:
2.0
3ko0P-3ujhA:
2.2		 3ko0M-3ujhA:
9.95
3ko0P-3ujhA:
9.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_O_TFPO201_1
(PROTEIN S100-A4)		 3ujh GLUCOSE-6-PHOSPHATE
ISOMERASE
(Toxoplasma
gondii) 		4 / 8 GLY A 157
CYH A 248
PHE A 247
PHE A 216
 G6Q  A 571 ( 3.3A)
None
None
None
 0.95A 3ko0O-3ujhA:
1.3
3ko0Q-3ujhA:
1.4		 3ko0O-3ujhA:
9.95
3ko0Q-3ujhA:
9.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_S_TFPS201_1
(PROTEIN S100-A4)		 3ujh GLUCOSE-6-PHOSPHATE
ISOMERASE
(Toxoplasma
gondii) 		4 / 7 PHE A 216
GLY A 157
CYH A 248
PHE A 247
 None
G6Q  A 571 ( 3.3A)
None
None
 0.92A 3ko0K-3ujhA:
2.0
3ko0S-3ujhA:
1.7		 3ko0K-3ujhA:
9.95
3ko0S-3ujhA:
9.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_T_TFPT201_1
(PROTEIN S100-A4)		 3ujh GLUCOSE-6-PHOSPHATE
ISOMERASE
(Toxoplasma
gondii) 		4 / 7 PHE A 216
GLY A 157
CYH A 248
PHE A 247
 None
G6Q  A 571 ( 3.3A)
None
None
 0.97A 3ko0R-3ujhA:
2.1
3ko0T-3ujhA:
2.1		 3ko0R-3ujhA:
9.95
3ko0T-3ujhA:
9.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K38_A_SAMA504_0
(ANAEROBIC
SULFATASE-MATURATING
ENZYME
KP18CYS PEPTIDE)		 2j6h GLUCOSAMINE-FRUCTOSE
-6-PHOSPHATE
AMINOTRANSFERASE
(Escherichia
coli) 		5 / 12 GLU A 396
GLN A 408
SER A 303
LEU A 346
LEU A 356
 None
None
G6Q  A1610 (-2.6A)
None
None
 1.46A 4k38A-2j6hA:
undetectable
4k38D-2j6hA:
undetectable		 4k38A-2j6hA:
20.42
4k38D-2j6hA:
2.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L8F_D_MTXD301_1
(GAMMA-GLUTAMYL
HYDROLASE)		 3ujh GLUCOSE-6-PHOSPHATE
ISOMERASE
(Toxoplasma
gondii) 		5 / 11 GLY A 276
GLY A 157
GLY A 156
GLU A 363
GLN A 358
 G6Q  A 571 ( 3.4A)
G6Q  A 571 ( 3.3A)
G6Q  A 571 ( 4.2A)
G6Q  A 571 ( 2.9A)
None
 1.01A 4l8fD-3ujhA:
3.3		 4l8fD-3ujhA:
19.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R29_D_SAMD301_1
(UNCHARACTERIZED
PROTEIN)		 4hjh PHOSPHOMANNOMUTASE
(Brucella
melitensis) 		3 / 3 ARG A 445
GLU A 322
TYR A 447
 G6Q  A 544 (-4.0A)
G6Q  A 544 (-2.3A)
EDO  A 548 (-4.8A)
 0.97A 4r29D-4hjhA:
undetectable		 4r29D-4hjhA:
17.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RV6_A_RPBA1103_1
(POLY [ADP-RIBOSE]
POLYMERASE 1)		 3ujh GLUCOSE-6-PHOSPHATE
ISOMERASE
(Toxoplasma
gondii) 		5 / 11 GLN A 512
GLU A 363
HIS A 356
GLY A 161
TYR A 278
 G6Q  A 571 ( 3.5A)
G6Q  A 571 ( 2.9A)
None
None
None
 1.44A 4rv6A-3ujhA:
undetectable		 4rv6A-3ujhA:
20.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RV6_B_RPBB1103_1
(POLY [ADP-RIBOSE]
POLYMERASE 1)		 3ujh GLUCOSE-6-PHOSPHATE
ISOMERASE
(Toxoplasma
gondii) 		5 / 11 GLN A 512
GLU A 363
HIS A 356
GLY A 161
TYR A 278
 G6Q  A 571 ( 3.5A)
G6Q  A 571 ( 2.9A)
None
None
None
 1.42A 4rv6B-3ujhA:
undetectable		 4rv6B-3ujhA:
20.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UCK_B_SAMB2409_0
(RNA-DIRECTED RNA
POLYMERASE L)		 2j6h GLUCOSAMINE-FRUCTOSE
-6-PHOSPHATE
AMINOTRANSFERASE
(Escherichia
coli) 		5 / 12 THR A 124
GLY A 157
SER A 176
ALA A 353
THR A 352
 ONL  A1609 (-4.3A)
None
None
None
G6Q  A1610 (-3.1A)
 1.16A 4uckB-2j6hA:
undetectable		 4uckB-2j6hA:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B2Q_A_ACTA1728_0
(CRISPR-ASSOCIATED
ENDONUCLEASE CAS9)		 4hjh PHOSPHOMANNOMUTASE
(Brucella
melitensis) 		3 / 3 ASN A 440
SER A  11
ARG A 346
 G6Q  A 544 ( 3.6A)
G6Q  A 544 (-2.4A)
SEP  A 104 ( 2.9A)
 0.95A 5b2qA-4hjhA:
2.2		 5b2qA-4hjhA:
14.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BTA_G_MFXG101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
TTACGTGCATAGTCATTCAT
GACC)		 4hjh PHOSPHOMANNOMUTASE
(Brucella
melitensis) 		4 / 7 SER A  88
ASP A 242
ARG A 247
GLY A 326
 None
MG  A 552 (-2.4A)
G6Q  A 544 (-3.2A)
None
 0.98A 5btaA-4hjhA:
3.2
5btaC-4hjhA:
3.2
5btaD-4hjhA:
undetectable		 5btaA-4hjhA:
23.19
5btaC-4hjhA:
23.19
5btaD-4hjhA:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ERG_B_SAMB401_1
(TRNA
(ADENINE(58)-N(1))-M
ETHYLTRANSFERASE
CATALYTIC SUBUNIT
TRM61)		 4hjh PHOSPHOMANNOMUTASE
(Brucella
melitensis) 		4 / 7 GLY A 299
GLU A 322
ASP A 261
ASP A 421
 G6Q  A 544 (-3.4A)
G6Q  A 544 (-2.3A)
None
None
 0.83A 5ergB-4hjhA:
undetectable		 5ergB-4hjhA:
22.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GWX_A_SAMA301_1
(GLYCINE SARCOSINE
N-METHYLTRANSFERASE)		 4hjh PHOSPHOMANNOMUTASE
(Brucella
melitensis) 		3 / 3 ARG A 445
ASN A 440
ASP A 244
 G6Q  A 544 (-4.0A)
G6Q  A 544 ( 3.6A)
MG  A 552 (-2.7A)
 0.90A 5gwxA-4hjhA:
undetectable		 5gwxA-4hjhA:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IMS_A_ACTA708_0
(ACETOLACTATE
SYNTHASE CATALYTIC
SUBUNIT,
MITOCHONDRIAL)		 2o2c GLUCOSE-6-PHOSPHATE
ISOMERASE,
GLYCOSOMAL
(Trypanosoma
brucei) 		3 / 3 GLY A 324
GLY A 325
GLN A 564
 G6Q  A5001 ( 4.8A)
G6Q  A5001 (-3.5A)
G6Q  A5001 (-3.7A)
 0.37A 5imsA-2o2cA:
4.5		 5imsA-2o2cA:
22.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IMS_A_ACTA708_0
(ACETOLACTATE
SYNTHASE CATALYTIC
SUBUNIT,
MITOCHONDRIAL)		 3ujh GLUCOSE-6-PHOSPHATE
ISOMERASE
(Toxoplasma
gondii) 		3 / 3 GLY A 275
GLY A 276
GLN A 512
 G6Q  A 571 ( 4.9A)
G6Q  A 571 ( 3.4A)
G6Q  A 571 ( 3.5A)
 0.42A 5imsA-3ujhA:
undetectable		 5imsA-3ujhA:
22.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IWU_A_ERYA404_0
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)		 2o2c GLUCOSE-6-PHOSPHATE
ISOMERASE,
GLYCOSOMAL
(Trypanosoma
brucei) 		5 / 12 THR A 216
PHE A 254
ALA A 273
SER A 208
ILE A 205
 None
None
None
G6Q  A5001 (-2.7A)
None
 1.35A 5iwuA-2o2cA:
undetectable		 5iwuA-2o2cA:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M5C_B_TA1B502_1
(TUBULIN BETA-2B
CHAIN)		 2j6h GLUCOSAMINE-FRUCTOSE
-6-PHOSPHATE
AMINOTRANSFERASE
(Escherichia
coli) 		5 / 12 GLU A 481
ALA A 404
SER A 401
GLY A 307
LEU A 346
 None
None
G6Q  A1610 (-4.1A)
None
None
 1.20A 5m5cB-2j6hA:
3.9		 5m5cB-2j6hA:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M5C_E_TA1E502_1
(TUBULIN BETA-2B
CHAIN)		 2j6h GLUCOSAMINE-FRUCTOSE
-6-PHOSPHATE
AMINOTRANSFERASE
(Escherichia
coli) 		5 / 10 GLU A 481
ALA A 404
SER A 401
GLY A 307
LEU A 346
 None
None
G6Q  A1610 (-4.1A)
None
None
 1.23A 5m5cE-2j6hA:
4.4		 5m5cE-2j6hA:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BAA_E_GBME2001_2
(ATP-BINDING CASSETTE
SUB-FAMILY C MEMBER
8)		 2o2c GLUCOSE-6-PHOSPHATE
ISOMERASE,
GLYCOSOMAL
(Trypanosoma
brucei) 		3 / 3 LEU A 210
THR A 266
ASN A 269
 None
G6Q  A5001 ( 4.7A)
None
 0.71A 6baaE-2o2cA:
undetectable		 6baaE-2o2cA:
16.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BAA_F_GBMF2001_2
(ATP-BINDING CASSETTE
SUB-FAMILY C MEMBER
8)		 2o2c GLUCOSE-6-PHOSPHATE
ISOMERASE,
GLYCOSOMAL
(Trypanosoma
brucei) 		3 / 3 LEU A 210
THR A 266
ASN A 269
 None
G6Q  A5001 ( 4.7A)
None
 0.71A 6baaF-2o2cA:
2.1		 6baaF-2o2cA:
16.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BAA_G_GBMG2001_2
(ATP-BINDING CASSETTE
SUB-FAMILY C MEMBER
8)		 2o2c GLUCOSE-6-PHOSPHATE
ISOMERASE,
GLYCOSOMAL
(Trypanosoma
brucei) 		3 / 3 LEU A 210
THR A 266
ASN A 269
 None
G6Q  A5001 ( 4.7A)
None
 0.71A 6baaG-2o2cA:
undetectable		 6baaG-2o2cA:
16.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BAA_H_GBMH2001_2
(ATP-BINDING CASSETTE
SUB-FAMILY C MEMBER
8)		 2o2c GLUCOSE-6-PHOSPHATE
ISOMERASE,
GLYCOSOMAL
(Trypanosoma
brucei) 		3 / 3 LEU A 210
THR A 266
ASN A 269
 None
G6Q  A5001 ( 4.7A)
None
 0.72A 6baaH-2o2cA:
undetectable		 6baaH-2o2cA:
16.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BOC_A_EU7A102_0
(MATRIX PROTEIN 2)		 2o2c GLUCOSE-6-PHOSPHATE
ISOMERASE,
GLYCOSOMAL
(Trypanosoma
brucei) 		4 / 6 SER A 208
ALA A 332
SER A 331
ALA A 257
 G6Q  A5001 (-2.7A)
None
None
None
 0.77A 6bocA-2o2cA:
undetectable
6bocB-2o2cA:
undetectable
6bocC-2o2cA:
undetectable
6bocD-2o2cA:
undetectable		 6bocA-2o2cA:
5.47
6bocB-2o2cA:
5.47
6bocC-2o2cA:
5.47
6bocD-2o2cA:
5.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CLX_A_SAMA401_0
(O-METHYLTRANSFERASE)		 2o2c GLUCOSE-6-PHOSPHATE
ISOMERASE,
GLYCOSOMAL
(Trypanosoma
brucei) 		5 / 12 ARG A 326
SER A 131
PHE A 128
VAL A 550
ASP A 560
 G6Q  A5001 (-3.9A)
None
None
None
None
 1.28A 6clxA-2o2cA:
2.7		 6clxA-2o2cA:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CLX_B_SAMB401_0
(O-METHYLTRANSFERASE)		 2o2c GLUCOSE-6-PHOSPHATE
ISOMERASE,
GLYCOSOMAL
(Trypanosoma
brucei) 		5 / 10 ARG A 326
SER A 131
PHE A 128
VAL A 550
ASP A 560
 G6Q  A5001 (-3.9A)
None
None
None
None
 1.28A 6clxB-2o2cA:
2.9		 6clxB-2o2cA:
21.83