SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'G6P'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A52_A_ESTA1_1
(ESTROGEN RECEPTOR)		 1gz5 ALPHA-TREHALOSE-PHOS
PHATE SYNTHASE
(Escherichia
coli) 		5 / 10 ALA A  11
GLU A  15
LEU A  28
ILE A 225
LEU A  23
 None
None
None
IMD  A 902 ( 4.3A)
G6P  A 901 ( 3.7A)
 1.47A 1a52A-1gz5A:
undetectable		 1a52A-1gz5A:
19.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWK_A_117A2_2
(HMG-COA REDUCTASE)		 5huu ALPHA,ALPHA-TREHALOS
E-PHOSPHATE SYNTHASE
[UDP-FORMING]
(Candida
albicans) 		5 / 11 ARG A 280
HIS A 354
SER A 317
LEU A 281
LEU A 327
 UDP  A 501 (-3.8A)
None
G6P  A 502 ( 4.3A)
None
None
 1.41A 1hwkB-5huuA:
undetectable		 1hwkB-5huuA:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWK_B_117B1_1
(HMG-COA REDUCTASE)		 5huu ALPHA,ALPHA-TREHALOS
E-PHOSPHATE SYNTHASE
[UDP-FORMING]
(Candida
albicans) 		5 / 11 ARG A 280
HIS A 354
SER A 317
LEU A 281
LEU A 327
 UDP  A 501 (-3.8A)
None
G6P  A 502 ( 4.3A)
None
None
 1.41A 1hwkA-5huuA:
undetectable		 1hwkA-5huuA:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWK_C_117C4_2
(HMG-COA REDUCTASE)		 5huu ALPHA,ALPHA-TREHALOS
E-PHOSPHATE SYNTHASE
[UDP-FORMING]
(Candida
albicans) 		5 / 11 ARG A 280
HIS A 354
SER A 317
LEU A 281
LEU A 327
 UDP  A 501 (-3.8A)
None
G6P  A 502 ( 4.3A)
None
None
 1.40A 1hwkD-5huuA:
undetectable		 1hwkD-5huuA:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWK_D_117D3_1
(HMG-COA REDUCTASE)		 5huu ALPHA,ALPHA-TREHALOS
E-PHOSPHATE SYNTHASE
[UDP-FORMING]
(Candida
albicans) 		5 / 11 ARG A 280
HIS A 354
SER A 317
LEU A 281
LEU A 327
 UDP  A 501 (-3.8A)
None
G6P  A 502 ( 4.3A)
None
None
 1.41A 1hwkC-5huuA:
undetectable		 1hwkC-5huuA:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QE6_A_SAMA400_1
(UNCHARACTERIZED
PROTEIN TFU_2867)		 5v0t ALPHA,ALPHA-TREHALOS
E-PHOSPHATE SYNTHASE
(UDP-FORMING)
(Paraburkholderia
xenovorans) 		3 / 3 ASN A  17
ARG A  18
ASP A 317
 None
G6P  A 502 (-3.8A)
None
 0.98A 2qe6A-5v0tA:
undetectable		 2qe6A-5v0tA:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QE6_B_SAMB400_1
(UNCHARACTERIZED
PROTEIN TFU_2867)		 5v0t ALPHA,ALPHA-TREHALOS
E-PHOSPHATE SYNTHASE
(UDP-FORMING)
(Paraburkholderia
xenovorans) 		3 / 3 ASN A  17
ARG A  18
ASP A 317
 None
G6P  A 502 (-3.8A)
None
 0.94A 2qe6B-5v0tA:
undetectable		 2qe6B-5v0tA:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XCT_G_CPFG1020_1
(DNA GYRASE SUBUNIT
B, DNA GYRASE
SUBUNIT A)		 5huu ALPHA,ALPHA-TREHALOS
E-PHOSPHATE SYNTHASE
[UDP-FORMING]
(Candida
albicans) 		3 / 3 ARG A 318
GLY A 319
SER A 332
 G6P  A 502 (-3.7A)
None
None
 0.50A 2xctB-5huuA:
undetectable		 2xctB-5huuA:
22.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GYQ_B_SAMB270_0
(RRNA
(ADENOSINE-2'-O-)-ME
THYLTRANSFERASE)		 1mor GLUCOSAMINE
6-PHOSPHATE SYNTHASE
(Escherichia
coli) 		5 / 11 ALA A 372
GLY A 358
ILE A 344
SER A 347
LEU A 346
 None
None
None
G6P  A 609 (-2.8A)
None
 1.24A 3gyqB-1morA:
2.6		 3gyqB-1morA:
23.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P5N_B_RBFB190_1
(RIBOFLAVIN UPTAKE
PROTEIN)		 6bzc GLUCOSE-6-PHOSPHATE
ISOMERASE
(Elizabethkingia
anophelis) 		5 / 12 THR A 212
ASN A 218
GLY A 154
ALA A 206
ALA A 241
 G6P  A 601 (-3.1A)
None
None
None
None
 1.15A 3p5nB-6bzcA:
undetectable		 3p5nB-6bzcA:
16.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K38_A_SAMA504_0
(ANAEROBIC
SULFATASE-MATURATING
ENZYME
KP18CYS PEPTIDE)		 1mor GLUCOSAMINE
6-PHOSPHATE SYNTHASE
(Escherichia
coli) 		5 / 12 GLU A 396
GLN A 408
SER A 303
LEU A 346
LEU A 356
 None
None
G6P  A 609 (-2.7A)
None
None
 1.29A 4k38A-1morA:
undetectable
4k38D-1morA:
undetectable		 4k38A-1morA:
20.00
4k38D-1morA:
3.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K39_A_SAMA504_0
(ANAEROBIC
SULFATASE-MATURATING
ENZYME)		 1mor GLUCOSAMINE
6-PHOSPHATE SYNTHASE
(Escherichia
coli) 		5 / 12 PHE A 314
ASN A 305
SER A 303
ILE A 373
LEU A 415
 None
None
G6P  A 609 (-2.7A)
None
None
 1.39A 4k39A-1morA:
undetectable		 4k39A-1morA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RTM_A_SAMA301_0
(DNA ADENINE
METHYLASE)		 4qfh GLUCOSE-6-PHOSPHATE
ISOMERASE
(Trypanosoma
cruzi) 		5 / 12 GLY A 207
PHE A 232
GLY A 205
ILE A 256
PRO A 213
 G6P  A 700 ( 4.3A)
None
None
None
None
 1.05A 4rtmA-4qfhA:
3.2		 4rtmA-4qfhA:
20.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RZV_B_032B801_2
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 1gz5 ALPHA-TREHALOSE-PHOS
PHATE SYNTHASE
(Escherichia
coli) 		4 / 5 ILE A 155
SER A  80
HIS A 132
ASP A 264
 G6P  A 901 (-4.8A)
None
G6P  A 901 (-4.5A)
None
 1.37A 4rzvB-1gz5A:
0.0		 4rzvB-1gz5A:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RZV_B_032B801_2
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 5v0t ALPHA,ALPHA-TREHALOS
E-PHOSPHATE SYNTHASE
(UDP-FORMING)
(Paraburkholderia
xenovorans) 		4 / 5 ILE A 165
SER A  90
HIS A 142
ASP A 279
 G6P  A 502 (-4.8A)
None
G6P  A 502 (-4.7A)
None
 1.27A 4rzvB-5v0tA:
undetectable		 4rzvB-5v0tA:
19.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XUM_A_IMNA501_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 1gz5 ALPHA-TREHALOSE-PHOS
PHATE SYNTHASE
(Escherichia
coli) 		5 / 12 PHE A  79
ILE A 155
LEU A 166
LEU A 172
LEU A 134
 None
G6P  A 901 (-4.8A)
None
None
None
 1.22A 4xumA-1gz5A:
undetectable		 4xumA-1gz5A:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A06_D_SORD1341_0
(ALDOSE-ALDOSE
OXIDOREDUCTASE)		 1u8x MALTOSE-6'-PHOSPHATE
GLUCOSIDASE
(Bacillus
subtilis) 		4 / 6 GLU X 111
GLY X 117
GLY X 116
ASP X  98
 G6P  X 902 ( 2.7A)
None
None
None
 0.98A 5a06D-1u8xX:
7.5		 5a06D-1u8xX:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A06_F_SORF1342_0
(ALDOSE-ALDOSE
OXIDOREDUCTASE)		 1u8x MALTOSE-6'-PHOSPHATE
GLUCOSIDASE
(Bacillus
subtilis) 		4 / 4 ARG X  88
HIS X 202
ALA X 151
GLU X 111
 NAD  X 900 (-3.5A)
MN  X 700 ( 3.4A)
NAD  X 900 ( 4.8A)
G6P  X 902 ( 2.7A)
 1.10A 5a06A-1u8xX:
7.5
5a06F-1u8xX:
7.2		 5a06A-1u8xX:
21.43
5a06F-1u8xX:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IH0_A_ERYA404_0
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)		 6bzc GLUCOSE-6-PHOSPHATE
ISOMERASE
(Elizabethkingia
anophelis) 		5 / 12 GLY A 186
PHE A 203
ALA A 222
SER A 158
ILE A 155
 None
None
None
G6P  A 601 (-2.6A)
None
 1.25A 5ih0A-6bzcA:
undetectable		 5ih0A-6bzcA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IMS_A_ACTA708_0
(ACETOLACTATE
SYNTHASE CATALYTIC
SUBUNIT,
MITOCHONDRIAL)		 4qfh GLUCOSE-6-PHOSPHATE
ISOMERASE
(Trypanosoma
cruzi) 		3 / 3 GLY A 325
GLY A 326
GLN A 565
 None
G6P  A 700 ( 4.0A)
G6P  A 700 ( 4.7A)
 0.39A 5imsA-4qfhA:
4.5		 5imsA-4qfhA:
24.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IMS_A_ACTA708_0
(ACETOLACTATE
SYNTHASE CATALYTIC
SUBUNIT,
MITOCHONDRIAL)		 6bzc GLUCOSE-6-PHOSPHATE
ISOMERASE
(Elizabethkingia
anophelis) 		3 / 3 GLY A 267
GLY A 268
GLN A 506
 None
G6P  A 601 ( 3.9A)
G6P  A 601 ( 4.2A)
 0.36A 5imsA-6bzcA:
4.8		 5imsA-6bzcA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OV9_A_CVIA609_0
(ACETYLCHOLINESTERASE)		 1gz5 ALPHA-TREHALOSE-PHOS
PHATE SYNTHASE
(Escherichia
coli) 		4 / 6 TYR A  76
TYR A  75
ASP A 302
TYR A 131
 G6P  A 901 (-4.5A)
None
None
G6P  A 901 ( 4.8A)
 1.47A 5ov9A-1gz5A:
0.0		 5ov9A-1gz5A:
23.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BOC_A_EU7A102_0
(MATRIX PROTEIN 2)		 4qfh GLUCOSE-6-PHOSPHATE
ISOMERASE
(Trypanosoma
cruzi) 		4 / 6 SER A 209
ALA A 333
SER A 332
ALA A 258
 G6P  A 700 (-2.7A)
None
None
None
 0.79A 6bocA-4qfhA:
undetectable
6bocB-4qfhA:
undetectable
6bocC-4qfhA:
undetectable
6bocD-4qfhA:
undetectable		 6bocA-4qfhA:
3.55
6bocB-4qfhA:
3.55
6bocC-4qfhA:
3.55
6bocD-4qfhA:
3.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BOC_A_EU7A102_0
(MATRIX PROTEIN 2)		 6bzc GLUCOSE-6-PHOSPHATE
ISOMERASE
(Elizabethkingia
anophelis) 		4 / 6 SER A 158
ALA A 275
SER A 274
ALA A 206
 G6P  A 601 (-2.6A)
None
None
None
 0.78A 6bocA-6bzcA:
undetectable
6bocB-6bzcA:
undetectable
6bocC-6bzcA:
undetectable
6bocD-6bzcA:
undetectable		 6bocA-6bzcA:
undetectable
6bocB-6bzcA:
undetectable
6bocC-6bzcA:
undetectable
6bocD-6bzcA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DH0_A_017A101_2
(PROTEASE)		 1gz5 ALPHA-TREHALOSE-PHOS
PHATE SYNTHASE
(Escherichia
coli) 		3 / 3 LEU A 181
ASP A 130
ILE A  27
 None
G6P  A 901 (-3.3A)
None
 0.60A 6dh0B-1gz5A:
0.0		 6dh0B-1gz5A:
10.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EXI_D_ADND502_0
(ADENOSYLHOMOCYSTEINA
SE)		 5v0t ALPHA,ALPHA-TREHALOS
E-PHOSPHATE SYNTHASE
(UDP-FORMING)
(Paraburkholderia
xenovorans) 		5 / 12 ASP A 140
HIS A  99
ASN A  91
HIS A 142
PHE A 161
 G6P  A 502 (-3.3A)
None
G6P  A 502 ( 4.6A)
G6P  A 502 (-4.7A)
None
 1.50A 6exiD-5v0tA:
3.2		 6exiD-5v0tA:
10.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_B_QPSB601_2
(-)		 1gz5 ALPHA-TREHALOSE-PHOS
PHATE SYNTHASE
(Escherichia
coli) 		6 / 12 GLY A  21
GLY A  22
LEU A  23
GLY A 301
HIS A 132
ARG A 262
 UDP  A 900 (-3.4A)
IMD  A 902 (-3.0A)
G6P  A 901 ( 3.7A)
None
G6P  A 901 (-4.5A)
UDP  A 900 ( 3.8A)
 1.16A 6gngB-1gz5A:
22.1		 6gngB-1gz5A:
22.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_B_QPSB601_2
(-)		 5v0t ALPHA,ALPHA-TREHALOS
E-PHOSPHATE SYNTHASE
(UDP-FORMING)
(Paraburkholderia
xenovorans) 		5 / 12 GLY A  30
GLY A  31
LEU A  32
HIS A 142
ARG A 277
 UDP  A 501 (-3.4A)
UDP  A 501 ( 3.1A)
G6P  A 502 (-3.9A)
G6P  A 502 (-4.7A)
UDP  A 501 ( 3.9A)
 0.88A 6gngB-5v0tA:
21.9		 6gngB-5v0tA:
25.08