SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'G5A'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JHO_A_NIOA991_1
(NICOTINATE
MONONUCLEOTIDE:5,6-D
IMETHYLBENZIMIDAZOLE
PHOSPHORIBOSYLTRANSF
ERASE)		 5f5w GLYCINE--TRNA LIGASE
ALPHA SUBUNIT
(Aquifex
aeolicus) 		5 / 9 GLY A 186
PHE A 189
LEU A  71
SER A 192
GLY A  65
 None
None
G5A  A 300 (-4.6A)
None
None
 1.22A 1jhoA-5f5wA:
undetectable		 1jhoA-5f5wA:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JHY_A_NIOA991_1
(NICOTINATE
MONONUCLEOTIDE:5,6-D
IMETHYLBENZIMIDAZOLE
PHOSPHORIBOSYLTRANSF
ERASE)		 5f5w GLYCINE--TRNA LIGASE
ALPHA SUBUNIT
(Aquifex
aeolicus) 		5 / 9 GLY A 186
PHE A 189
LEU A  71
SER A 192
GLY A  65
 None
None
G5A  A 300 (-4.6A)
None
None
 1.22A 1jhyA-5f5wA:
undetectable		 1jhyA-5f5wA:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1L4N_A_NIOA991_1
(NICOTINATE-NUCLEOTID
E--DIMETHYLBENZIMIDA
ZOLE
PHOSPHORIBOSYLTRANSF
ERASE)		 5f5w GLYCINE--TRNA LIGASE
ALPHA SUBUNIT
(Aquifex
aeolicus) 		5 / 9 GLY A 186
PHE A 189
LEU A  71
SER A 192
GLY A  65
 None
None
G5A  A 300 (-4.6A)
None
None
 1.26A 1l4nA-5f5wA:
undetectable		 1l4nA-5f5wA:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1L5K_A_NIOA991_1
(NICOTINATE-NUCLEOTID
E--DIMETHYLBENZIMIDA
ZOLE
PHOSPHORIBOSYLTRANSF
ERASE)		 5f5w GLYCINE--TRNA LIGASE
ALPHA SUBUNIT
(Aquifex
aeolicus) 		5 / 9 GLY A 186
PHE A 189
LEU A  71
SER A 192
GLY A  65
 None
None
G5A  A 300 (-4.6A)
None
None
 1.23A 1l5kA-5f5wA:
undetectable		 1l5kA-5f5wA:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1L5M_A_NIOA991_1
(NICOTINATE-NUCLEOTID
E--DIMETHYLBENZIMIDA
ZOLE
PHOSPHORIBOSYLTRANSF
ERASE)		 5f5w GLYCINE--TRNA LIGASE
ALPHA SUBUNIT
(Aquifex
aeolicus) 		5 / 9 GLY A 186
PHE A 189
LEU A  71
SER A 192
GLY A  65
 None
None
G5A  A 300 (-4.6A)
None
None
 1.23A 1l5mA-5f5wA:
undetectable		 1l5mA-5f5wA:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NBH_A_SAMA293_1
(GLYCINE
N-METHYLTRANSFERASE)		 5f5w GLYCINE--TRNA LIGASE
ALPHA SUBUNIT
(Aquifex
aeolicus) 		3 / 3 ARG A 257
ASP A  61
ASN A  67
 None
G5A  A 300 (-3.9A)
None
 0.80A 1nbhA-5f5wA:
undetectable		 1nbhA-5f5wA:
18.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NBH_D_SAMD3293_1
(GLYCINE
N-METHYLTRANSFERASE)		 5f5w GLYCINE--TRNA LIGASE
ALPHA SUBUNIT
(Aquifex
aeolicus) 		3 / 3 ARG A 257
ASP A  61
ASN A  67
 None
G5A  A 300 (-3.9A)
None
 0.80A 1nbhD-5f5wA:
undetectable		 1nbhD-5f5wA:
18.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QWC_A_H4BA901_1
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 5f5w GLYCINE--TRNA LIGASE
ALPHA SUBUNIT
(Aquifex
aeolicus) 		3 / 3 ARG A 163
VAL A 129
TRP A 130
 G5A  A 300 (-4.0A)
None
None
 1.25A 1qwcA-5f5wA:
undetectable		 1qwcA-5f5wA:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VAG_A_H4BA901_1
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 5f5w GLYCINE--TRNA LIGASE
ALPHA SUBUNIT
(Aquifex
aeolicus) 		3 / 3 ARG A 163
VAL A 129
TRP A 130
 G5A  A 300 (-4.0A)
None
None
 1.27A 1vagA-5f5wA:
0.5		 1vagA-5f5wA:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZVI_A_H4BA901_1
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 5f5w GLYCINE--TRNA LIGASE
ALPHA SUBUNIT
(Aquifex
aeolicus) 		3 / 3 ARG A 163
VAL A 129
TRP A 130
 G5A  A 300 (-4.0A)
None
None
 1.25A 1zviA-5f5wA:
undetectable		 1zviA-5f5wA:
21.25
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3RGL_A_GLYA301_0
(GLYCYL-TRNA
SYNTHETASE ALPHA
SUBUNIT)		 5f5w GLYCINE--TRNA LIGASE
ALPHA SUBUNIT
(Aquifex
aeolicus) 		8 / 8 ALA A  31
GLY A  32
THR A  33
ARG A  58
GLN A  76
GLN A  78
GLU A 156
THR A 158
 G5A  A 300 ( 3.9A)
None
G5A  A 300 (-3.9A)
G5A  A 300 (-3.1A)
G5A  A 300 (-3.3A)
G5A  A 300 ( 4.6A)
G5A  A 300 (-3.0A)
G5A  A 300 (-3.4A)
 0.40A 3rglA-5f5wA:
40.8		 3rglA-5f5wA:
59.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L1A_A_AB1A101_1
(MDR769 HIV-1
PROTEASE)		 5f5w GLYCINE--TRNA LIGASE
ALPHA SUBUNIT
(Aquifex
aeolicus) 		5 / 11 GLY A 146
ALA A 145
ILE A 229
THR A  38
THR A  33
 None
None
None
None
G5A  A 300 (-3.9A)
 1.04A 4l1aA-5f5wA:
undetectable		 4l1aA-5f5wA:
15.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q15_B_HFGB803_0
(PROLINE--TRNA LIGASE)		 4h2x AMINO
ACID--[ACYL-CARRIER-
PROTEIN] LIGASE 1
(Agrobacterium
fabrum;
Bradyrhizobium
diazoefficiens) 		5 / 12 LEU B  76
PHE B  85
PRO B 128
ARG B 159
GLU B 176
 None
None
None
G5A  B 402 (-2.8A)
ZN  B 401 ( 2.3A)
 0.85A 4q15B-4h2xB:
21.1		 4q15B-4h2xB:
19.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X5I_A_FOLA201_1
(DIHYDROFOLATE
REDUCTASE)		 5f5w GLYCINE--TRNA LIGASE
ALPHA SUBUNIT
(Aquifex
aeolicus) 		3 / 3 ASP A 113
ARG A  70
ARG A 163
 None
None
G5A  A 300 (-4.0A)
 0.61A 4x5iA-5f5wA:
undetectable		 4x5iA-5f5wA:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YDQ_A_HFGA802_0
(PROLINE--TRNA LIGASE)		 4h2x AMINO
ACID--[ACYL-CARRIER-
PROTEIN] LIGASE 1
(Agrobacterium
fabrum;
Bradyrhizobium
diazoefficiens) 		5 / 12 LEU B  76
PHE B  85
PRO B 128
ARG B 159
GLU B 176
 None
None
None
G5A  B 402 (-2.8A)
ZN  B 401 ( 2.3A)
 0.76A 4ydqA-4h2xB:
19.9		 4ydqA-4h2xB:
19.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EAJ_B_FOLB201_1
(DIHYDROFOLATE
REDUCTASE)		 5f5w GLYCINE--TRNA LIGASE
ALPHA SUBUNIT
(Aquifex
aeolicus) 		3 / 3 ASP A 113
ARG A  70
ARG A 163
 None
None
G5A  A 300 (-4.0A)
 0.83A 5eajB-5f5wA:
undetectable		 5eajB-5f5wA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FVO_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5f5w GLYCINE--TRNA LIGASE
ALPHA SUBUNIT
(Aquifex
aeolicus) 		3 / 3 ARG A 163
VAL A 129
TRP A 130
 G5A  A 300 (-4.0A)
None
None
 1.20A 5fvoA-5f5wA:
undetectable		 5fvoA-5f5wA:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IFU_B_GBMB801_1
(PROLINE--TRNA LIGASE)		 5f5w GLYCINE--TRNA LIGASE
ALPHA SUBUNIT
(Aquifex
aeolicus) 		5 / 9 TYR A  92
LEU A  96
ARG A 163
ILE A 164
GLY A 160
 None
None
G5A  A 300 (-4.0A)
None
G5A  A 300 (-3.3A)
 1.35A 5ifuB-5f5wA:
5.9		 5ifuB-5f5wA:
22.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QGK_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 5f5w GLYCINE--TRNA LIGASE
ALPHA SUBUNIT
(Aquifex
aeolicus) 		3 / 3 VAL A  53
TYR A  75
GLN A  76
 None
None
G5A  A 300 (-3.3A)
 0.65A 5qgkA-5f5wA:
undetectable		 5qgkA-5f5wA:
19.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QGR_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 5f5w GLYCINE--TRNA LIGASE
ALPHA SUBUNIT
(Aquifex
aeolicus) 		3 / 3 VAL A  53
TYR A  75
GLN A  76
 None
None
G5A  A 300 (-3.3A)
 0.64A 5qgrA-5f5wA:
undetectable		 5qgrA-5f5wA:
19.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QGT_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 5f5w GLYCINE--TRNA LIGASE
ALPHA SUBUNIT
(Aquifex
aeolicus) 		3 / 3 VAL A  53
TYR A  75
GLN A  76
 None
None
G5A  A 300 (-3.3A)
 0.69A 5qgtA-5f5wA:
undetectable		 5qgtA-5f5wA:
19.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UUN_B_ACTB309_0
(GLUTATHIONE
S-TRANSFERASE-LIKE
PROTEIN)		 4h2x AMINO
ACID--[ACYL-CARRIER-
PROTEIN] LIGASE 1
(Agrobacterium
fabrum;
Bradyrhizobium
diazoefficiens) 		3 / 3 TYR B 135
ALA B 129
TYR B 132
 None
G5A  B 402 (-3.6A)
None
 0.82A 5uunB-4h2xB:
undetectable		 5uunB-4h2xB:
22.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIP_A_HFGA1003_0
(PROLYL-TRNA
SYNTHETASE, PUTATIVE)		 4h2x AMINO
ACID--[ACYL-CARRIER-
PROTEIN] LIGASE 1
(Agrobacterium
fabrum;
Bradyrhizobium
diazoefficiens) 		5 / 12 LEU B  76
PHE B  85
PRO B 128
ARG B 159
GLY B 283
 None
None
None
G5A  B 402 (-2.8A)
CL  B 403 ( 3.2A)
 1.07A 5xipA-4h2xB:
18.5		 5xipA-4h2xB:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIQ_B_HFGB1002_0
(PROLYL-TRNA
SYNTHETASE (PRORS))		 4h2x AMINO
ACID--[ACYL-CARRIER-
PROTEIN] LIGASE 1
(Agrobacterium
fabrum;
Bradyrhizobium
diazoefficiens) 		5 / 12 LEU B  76
PHE B  85
PRO B 128
ARG B 159
GLU B 176
 None
None
None
G5A  B 402 (-2.8A)
ZN  B 401 ( 2.3A)
 0.87A 5xiqB-4h2xB:
10.1		 5xiqB-4h2xB:
19.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIQ_D_HFGD1002_0
(PROLYL-TRNA
SYNTHETASE (PRORS))		 4h2x AMINO
ACID--[ACYL-CARRIER-
PROTEIN] LIGASE 1
(Agrobacterium
fabrum;
Bradyrhizobium
diazoefficiens) 		5 / 12 LEU B  76
PHE B  85
PRO B 128
ARG B 159
GLU B 176
 None
None
None
G5A  B 402 (-2.8A)
ZN  B 401 ( 2.3A)
 0.86A 5xiqD-4h2xB:
19.6		 5xiqD-4h2xB:
19.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BNI_A_ADNA602_1
(LYSINE--TRNA LIGASE)		 4h2x AMINO
ACID--[ACYL-CARRIER-
PROTEIN] LIGASE 1
(Agrobacterium
fabrum;
Bradyrhizobium
diazoefficiens) 		5 / 10 ARG B 159
GLU B 161
PHE B 172
GLY B 283
ARG B 286
 G5A  B 402 (-2.8A)
G5A  B 402 (-3.8A)
G5A  B 402 (-3.7A)
CL  B 403 ( 3.2A)
G5A  B 402 ( 3.8A)
 0.46A 6bniA-4h2xB:
11.1		 6bniA-4h2xB:
12.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BNI_B_ADNB602_1
(LYSINE--TRNA LIGASE)		 4h2x AMINO
ACID--[ACYL-CARRIER-
PROTEIN] LIGASE 1
(Agrobacterium
fabrum;
Bradyrhizobium
diazoefficiens) 		5 / 10 ARG B 159
GLU B 161
PHE B 172
GLY B 283
ARG B 286
 G5A  B 402 (-2.8A)
G5A  B 402 (-3.8A)
G5A  B 402 (-3.7A)
CL  B 403 ( 3.2A)
G5A  B 402 ( 3.8A)
 0.51A 6bniB-4h2xB:
12.0		 6bniB-4h2xB:
12.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BPL_B_PA1B605_1
(LIPID A EXPORT
ATP-BINDING/PERMEASE
PROTEIN MSBA)		 5f5w GLYCINE--TRNA LIGASE
ALPHA SUBUNIT
(Aquifex
aeolicus) 		3 / 3 ARG A 163
ARG A  63
ARG A  58
 G5A  A 300 (-4.0A)
None
G5A  A 300 (-3.1A)
 1.08A 6bplA-5f5wA:
2.1
6bplB-5f5wA:
undetectable		 6bplA-5f5wA:
14.81
6bplB-5f5wA:
14.81