SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'G4P'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BM9_B_SAMB301_0
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 3vr1 PEPTIDE CHAIN
RELEASE FACTOR 3
(Desulfovibrio
vulgaris) 		5 / 12 LEU A  32
LEU A 267
GLU A 265
GLY A 262
ASP A 144
 None
None
None
None
G4P  A 601 (-2.9A)
 1.20A 2bm9B-3vr1A:
undetectable		 2bm9B-3vr1A:
17.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S3N_A_DLUA398_1
(PFV INTEGRASE)		 2j4r EXOPOLYPHOSPHATASE
(Aquifex
aeolicus) 		4 / 8 ASP A 141
GLY A 210
GLU A 148
ARG A  22
 None
G4P  A1307 ( 3.7A)
None
G4P  A1307 (-3.5A)
 1.02A 3s3nA-2j4rA:
undetectable		 3s3nA-2j4rA:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V4T_A_ACTA503_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)		 2j4r EXOPOLYPHOSPHATASE
(Aquifex
aeolicus) 		3 / 3 ARG A 121
GLU A 119
THR A 115
 None
G4P  A1307 ( 4.5A)
None
 0.78A 3v4tA-2j4rA:
undetectable		 3v4tA-2j4rA:
23.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AC9_C_DXCC1478_0
(MJ0495-LIKE PROTEIN)		 3vr1 PEPTIDE CHAIN
RELEASE FACTOR 3
(Desulfovibrio
vulgaris) 		4 / 7 ASP A 144
GLY A 173
SER A 256
PHE A 261
 G4P  A 601 (-2.9A)
None
G4P  A 601 (-3.3A)
None
 0.81A 4ac9C-3vr1A:
16.9		 4ac9C-3vr1A:
24.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q15_A_HFGA803_0
(PROLINE--TRNA LIGASE)		 2j4r EXOPOLYPHOSPHATASE
(Aquifex
aeolicus) 		5 / 12 LEU A 219
GLU A 264
VAL A 263
THR A 214
GLY A 296
 None
G4P  A1307 ( 3.7A)
None
None
None
 1.24A 4q15A-2j4rA:
undetectable		 4q15A-2j4rA:
23.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KPR_A_PAUA404_0
(PANTOTHENATE KINASE
3)		 2j4r EXOPOLYPHOSPHATASE
(Aquifex
aeolicus) 		4 / 5 GLU A 299
GLY A 210
SER A 293
GLY A 208
 None
G4P  A1307 ( 3.7A)
None
None
 1.12A 5kprA-2j4rA:
5.6		 5kprA-2j4rA:
25.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V0V_A_8QPA613_1
(SERUM ALBUMIN)		 2j4r EXOPOLYPHOSPHATASE
(Aquifex
aeolicus) 		4 / 8 ALA A  84
VAL A 111
PHE A  99
THR A  87
 None
None
None
G4P  A1307 (-3.7A)
 0.84A 5v0vA-2j4rA:
undetectable		 5v0vA-2j4rA:
18.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WYQ_A_SAMA401_0
(TRNA
(GUANINE-N(1)-)-METH
YLTRANSFERASE)		 5vog PUTATIVE
PHOSPHORIBOSYLTRANSF
ERASE
(Neisseria
gonorrhoeae) 		5 / 12 GLY A  37
VAL A  99
GLY A  39
GLY A  40
PRO A  43
 None
G4P  A 203 (-4.9A)
G4P  A 203 (-3.5A)
None
None
 1.11A 5wyqA-5vogA:
undetectable		 5wyqA-5vogA:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AG0_A_ACRA606_0
(ALPHA-AMYLASE)		 2j4r EXOPOLYPHOSPHATASE
(Aquifex
aeolicus) 		5 / 7 GLY A 211
GLY A 210
GLY A 143
GLY A 145
GLY A 144
 G4P  A1307 (-3.8A)
G4P  A1307 ( 3.7A)
G4P  A1307 ( 3.7A)
None
G4P  A1307 ( 4.7A)
 1.08A 6ag0A-2j4rA:
undetectable		 6ag0A-2j4rA:
11.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FBV_D_FI8D1904_0
(DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA
DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA')		 5vog PUTATIVE
PHOSPHORIBOSYLTRANSF
ERASE
(Neisseria
gonorrhoeae) 		4 / 8 ILE A  34
THR A 105
VAL A 104
GLU A 107
 None
EDO  A 202 ( 3.4A)
G4P  A 203 (-4.6A)
None
 1.06A 6fbvC-5vogA:
undetectable		 6fbvC-5vogA:
9.46