SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'G44'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AQ7_B_AG2B4_1
(TRYPSIN
AERUGINOSIN 98-B)		 2pks THROMBIN HEAVY CHAIN
FRAGMENT
(Homo
sapiens) 		5 / 8 ASP C 229
SER C 235
VAL C 255
GLY C 258
GLY C 268
 G44  C 101 (-2.6A)
G44  C 101 (-3.5A)
None
G44  C 101 (-3.3A)
G44  C 101 (-3.0A)
 0.57A 1aq7A-2pksC:
9.6		 1aq7A-2pksC:
21.43
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1BCU_H_PRLH280_0
(ALPHA-THROMBIN)		 2pks THROMBIN HEAVY CHAIN
FRAGMENT
(Homo
sapiens) 		5 / 9 ALA C 230
GLU C 232
SER C 235
VAL C 255
TRP C 257
 G44  C 101 (-3.8A)
None
G44  C 101 (-3.5A)
None
G44  C 101 (-4.1A)
 0.85A 1bcuH-2pksC:
14.2		 1bcuH-2pksC:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1BCU_H_PRLH280_0
(ALPHA-THROMBIN)		 2pks THROMBIN HEAVY CHAIN
FRAGMENT
(Homo
sapiens) 		7 / 9 ASP C 229
ALA C 230
SER C 235
VAL C 255
TRP C 257
GLY C 258
GLY C 268
 G44  C 101 (-2.6A)
G44  C 101 (-3.8A)
G44  C 101 (-3.5A)
None
G44  C 101 (-4.1A)
G44  C 101 (-3.3A)
G44  C 101 (-3.0A)
 0.27A 1bcuH-2pksC:
14.2		 1bcuH-2pksC:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1DWC_H_MITH1_1
(ALPHA-THROMBIN
(LARGE SUBUNIT))		 2pks THROMBIN HEAVY CHAIN
FRAGMENT
(Homo
sapiens) 		5 / 9 ILE C 209
ASP C 229
SER C 235
TRP C 257
GLY C 268
 G44  C 101 (-3.9A)
G44  C 101 (-2.6A)
G44  C 101 (-3.5A)
G44  C 101 (-4.1A)
G44  C 101 (-3.0A)
 0.40A 1dwcH-2pksC:
11.9		 1dwcH-2pksC:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1ETR_H_MITH1_1
(EPSILON-THROMBIN)		 2pks THROMBIN HEAVY CHAIN
FRAGMENT
(Homo
sapiens) 		7 / 12 ASP C 229
GLU C 232
SER C 235
VAL C 255
TRP C 257
GLY C 258
GLY C 268
 G44  C 101 (-2.6A)
None
G44  C 101 (-3.5A)
None
G44  C 101 (-4.1A)
G44  C 101 (-3.3A)
G44  C 101 (-3.0A)
 0.65A 1etrH-2pksC:
12.1		 1etrH-2pksC:
38.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1F5L_A_AMRA301_1
(UROKINASE-TYPE
PLASMINOGEN
ACTIVATOR)		 2pks THROMBIN HEAVY CHAIN
FRAGMENT
(Homo
sapiens) 		5 / 8 ASP C 229
SER C 235
VAL C 255
GLY C 258
GLY C 268
 G44  C 101 (-2.6A)
G44  C 101 (-3.5A)
None
G44  C 101 (-3.3A)
G44  C 101 (-3.0A)
 0.45A 1f5lA-2pksC:
12.3		 1f5lA-2pksC:
19.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TNL_A_TPAA900_1
(TRYPSIN)		 2pks THROMBIN HEAVY CHAIN
FRAGMENT
(Homo
sapiens) 		5 / 6 ASP C 229
SER C 235
VAL C 255
GLY C 258
GLY C 268
 G44  C 101 (-2.6A)
G44  C 101 (-3.5A)
None
G44  C 101 (-3.3A)
G44  C 101 (-3.0A)
 0.33A 1tnlA-2pksC:
12.1		 1tnlA-2pksC:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OTV_A_NCAA1301_0
(CATIONIC TRYPSIN)		 2pks THROMBIN HEAVY CHAIN
FRAGMENT
(Homo
sapiens) 		5 / 6 ASP C 229
SER C 235
VAL C 255
GLY C 258
GLY C 268
 G44  C 101 (-2.6A)
G44  C 101 (-3.5A)
None
G44  C 101 (-3.3A)
G44  C 101 (-3.0A)
 0.24A 2otvA-2pksC:
12.4		 2otvA-2pksC:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2P16_A_GG2A298_1
(COAGULATION FACTOR X
(EC 3.4.21.6)
(STUART FACTOR)
(STUART-PROWER
FACTOR))		 2pks THROMBIN HEAVY CHAIN
FRAGMENT
(Homo
sapiens) 		8 / 12 ASP C 229
ALA C 230
SER C 235
VAL C 255
TRP C 257
GLY C 258
GLY C 268
TYR C 270
 G44  C 101 (-2.6A)
G44  C 101 (-3.8A)
G44  C 101 (-3.5A)
None
G44  C 101 (-4.1A)
G44  C 101 (-3.3A)
G44  C 101 (-3.0A)
None
 0.35A 2p16A-2pksC:
14.4		 2p16A-2pksC:
23.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VIN_A_505A1247_1
(UROKINASE-TYPE
PLASMINOGEN
ACTIVATOR CHAIN B)		 2pks THROMBIN HEAVY CHAIN
FRAGMENT
(Homo
sapiens) 		5 / 8 ASP C 229
SER C 235
VAL C 255
GLY C 258
GLY C 268
 G44  C 101 (-2.6A)
G44  C 101 (-3.5A)
None
G44  C 101 (-3.3A)
G44  C 101 (-3.0A)
 0.47A 2vinA-2pksC:
undetectable		 2vinA-2pksC:
19.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W26_A_RIVA1001_1
(ACTIVATED FACTOR XA
HEAVY CHAIN)		 2pks THROMBIN HEAVY CHAIN
FRAGMENT
(Homo
sapiens) 		9 / 12 ASP C 229
ALA C 230
SER C 235
VAL C 255
TRP C 257
GLY C 258
GLY C 260
GLY C 268
TYR C 270
 G44  C 101 (-2.6A)
G44  C 101 (-3.8A)
G44  C 101 (-3.5A)
None
G44  C 101 (-4.1A)
G44  C 101 (-3.3A)
None
G44  C 101 (-3.0A)
None
 0.37A 2w26A-2pksC:
12.7		 2w26A-2pksC:
23.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GY3_A_PNTA246_0
(CATIONIC TRYPSIN)		 2pks THROMBIN HEAVY CHAIN
FRAGMENT
(Homo
sapiens) 		5 / 11 ASP C 229
SER C 235
TRP C 257
GLY C 258
GLY C 268
 G44  C 101 (-2.6A)
G44  C 101 (-3.5A)
G44  C 101 (-4.1A)
G44  C 101 (-3.3A)
G44  C 101 (-3.0A)
 0.33A 3gy3A-2pksC:
11.8		 3gy3A-2pksC:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KPD_B_SAMB1000_1
(UNCHARACTERIZED
PROTEIN MJ0100)		 5fyj GP120 ENV ECTODOMAIN
(Human
immunodeficiency
virus
1) 		3 / 3 ASN G 442
ASN G 302
GLU G 381
 NAG  G4421 (-1.8A)
None
None
 0.92A 3kpdC-5fyjG:
undetectable		 3kpdC-5fyjG:
15.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KPD_C_SAMC1000_0
(UNCHARACTERIZED
PROTEIN MJ0100)		 5fyj GP120 ENV ECTODOMAIN
(Human
immunodeficiency
virus
1) 		3 / 3 ASN G 442
ASN G 302
GLU G 381
 NAG  G4421 (-1.8A)
None
None
 0.83A 3kpdB-5fyjG:
undetectable		 3kpdB-5fyjG:
15.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RXF_A_4APA9_1
(CATIONIC TRYPSIN)		 2pks THROMBIN HEAVY CHAIN
FRAGMENT
(Homo
sapiens) 		5 / 6 SER C 235
VAL C 255
TRP C 257
GLY C 258
GLY C 268
 G44  C 101 (-3.5A)
None
G44  C 101 (-4.1A)
G44  C 101 (-3.3A)
G44  C 101 (-3.0A)
 0.27A 3rxfA-2pksC:
9.8		 3rxfA-2pksC:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RXH_A_HSMA7_1
(CATIONIC TRYPSIN)		 2pks THROMBIN HEAVY CHAIN
FRAGMENT
(Homo
sapiens) 		4 / 5 ASP C 229
SER C 235
VAL C 255
GLY C 268
 G44  C 101 (-2.6A)
G44  C 101 (-3.5A)
None
G44  C 101 (-3.0A)
 0.33A 3rxhA-2pksC:
12.2		 3rxhA-2pksC:
21.43
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4HFP_B_15UB402_1
(PROTHROMBIN)		 2pks THROMBIN HEAVY CHAIN
FRAGMENT
(Homo
sapiens) 		5 / 12 ILE C 209
ASP C 229
GLU C 232
GLY C 258
GLY C 268
 G44  C 101 (-3.9A)
G44  C 101 (-2.6A)
None
G44  C 101 (-3.3A)
G44  C 101 (-3.0A)
 0.69A 4hfpB-2pksC:
12.1		 4hfpB-2pksC:
99.02
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4HFP_D_15UD402_1
(PROTHROMBIN)		 2pks THROMBIN HEAVY CHAIN
FRAGMENT
(Homo
sapiens) 		7 / 12 ILE C 209
ASP C 229
ALA C 230
GLU C 232
VAL C 255
TRP C 257
GLY C 268
 G44  C 101 (-3.9A)
G44  C 101 (-2.6A)
G44  C 101 (-3.8A)
None
None
G44  C 101 (-4.1A)
G44  C 101 (-3.0A)
 0.65A 4hfpD-2pksC:
15.6		 4hfpD-2pksC:
99.02
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4RN6_B_15UB301_1
(THROMBIN HEAVY CHAIN)		 2pks THROMBIN HEAVY CHAIN
FRAGMENT
(Homo
sapiens) 		5 / 12 ALA C 230
VAL C 255
TRP C 257
GLY C 258
GLY C 268
 G44  C 101 (-3.8A)
None
G44  C 101 (-4.1A)
G44  C 101 (-3.3A)
G44  C 101 (-3.0A)
 0.75A 4rn6B-2pksC:
9.6		 4rn6B-2pksC:
99.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HW4_C_SAMC801_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE I)		 2pks THROMBIN HEAVY CHAIN
FRAGMENT
(Homo
sapiens) 		5 / 12 GLY C 228
ALA C 230
PHE C 216
TYR C 270
VAL C 255
 None
G44  C 101 (-3.8A)
None
None
None
 1.22A 5hw4C-2pksC:
undetectable		 5hw4C-2pksC:
16.40