SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'G3A'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1XZX_X_T3X500_2 (THYROID HORMONE RECEPTOR BETA-1)	5c8s	GUANINE-N7 METHYLTRANSFERASE (Severe acute respiratory syndrome-related coronavirus)	3 / 3	PHE B 426 ARG B 84 ASN B 410	G3A B 606 (-3.4A) None None	0.91A	1xzxX-5c8sB: undetectable	1xzxX-5c8sB: 21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3U9F_C_CLMC221_0 (CHLORAMPHENICOL ACETYLTRANSFERASE)	5c8s	GUANINE-N7 METHYLTRANSFERASE (Severe acute respiratory syndrome-related coronavirus)	5 / 11	PHE B 506 CYH B 399 SER B 418 VAL B 398 PHE B 436	G3A B 606 (-3.8A) None None None None	1.47A	3u9fA-5c8sB: undetectable 3u9fC-5c8sB: undetectable	3u9fA-5c8sB: 18.38 3u9fC-5c8sB: 18.38
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	5C8T_B_SAMB605_0 (GUANINE-N7 METHYLTRANSFERASE)	5c8s	GUANINE-N7 METHYLTRANSFERASE (Severe acute respiratory syndrome-related coronavirus)	11 / 11	TRP B 292 GLY B 333 PRO B 335 ASP B 352 ALA B 353 PHE B 367 TYR B 368 TRP B 385 ASN B 386 CYH B 387 VAL B 389	None SAH B 605 (-3.3A) SAH B 605 (-3.8A) SAH B 605 (-2.3A) SAH B 605 (-3.5A) SAH B 605 (-3.5A) None G3A B 606 ( 4.1A) G3A B 606 ( 3.8A) SAH B 605 ( 3.8A) SAH B 605 (-4.7A)	0.41A	5c8tB-5c8sB: 49.2	5c8tB-5c8sB: 100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	5C8T_D_SAMD605_0 (GUANINE-N7 METHYLTRANSFERASE)	5c8s	GUANINE-N7 METHYLTRANSFERASE (Severe acute respiratory syndrome-related coronavirus)	10 / 10	TRP B 292 GLY B 333 ASN B 334 PRO B 335 ASP B 352 ALA B 353 GLN B 354 PHE B 367 TRP B 385 CYH B 387	None SAH B 605 (-3.3A) SAH B 605 (-4.1A) SAH B 605 (-3.8A) SAH B 605 (-2.3A) SAH B 605 (-3.5A) None SAH B 605 (-3.5A) G3A B 606 ( 4.1A) SAH B 605 ( 3.8A)	0.71A	5c8tD-5c8sB: 45.9	5c8tD-5c8sB: 100.00

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["1XZX_X_T3X500_2","THYROID HORMONE RECEPTOR BETA-1","5c8s","GUANINE-N7 METHYLTRANSFERASE","Severe acute respiratory syndrome-related coronavirus",3,"PHE B 426;ARG B  84;ASN B 410","G3A B 606 (-3.4A);None;None","0.91A","1xzxX-5c8sB:undetectable",null],["3U9F_C_CLMC221_0","CHLORAMPHENICOL ACETYLTRANSFERASE","5c8s","GUANINE-N7 METHYLTRANSFERASE","Severe acute respiratory syndrome-related coronavirus",5,"PHE B 506;CYH B 399;SER B 418;VAL B 398;PHE B 436","G3A B 606 (-3.8A);None;None;None;None","1.47A","3u9fA-5c8sB:undetectable;3u9fC-5c8sB:undetectable","1xzxX-5c8sB:21.02"],["5C8T_B_SAMB605_0","GUANINE-N7 METHYLTRANSFERASE","5c8s","GUANINE-N7 METHYLTRANSFERASE","Severe acute respiratory syndrome-related coronavirus",11,"TRP B 292;GLY B 333;PRO B 335;ASP B 352;ALA B 353;PHE B 367;TYR B 368;TRP B 385;ASN B 386;CYH B 387;VAL B 389","None;SAH B 605 (-3.3A);SAH B 605 (-3.8A);SAH B 605 (-2.3A);SAH B 605 (-3.5A);SAH B 605 (-3.5A);None;G3A B 606 ( 4.1A);G3A B 606 ( 3.8A);SAH B 605 ( 3.8A);SAH B 605 (-4.7A)","0.41A","5c8tB-5c8sB:49.2","3u9fA-5c8sB:18.38;3u9fC-5c8sB:18.38"],["5C8T_D_SAMD605_0","GUANINE-N7 METHYLTRANSFERASE","5c8s","GUANINE-N7 METHYLTRANSFERASE","Severe acute respiratory syndrome-related coronavirus",10,"TRP B 292;GLY B 333;ASN B 334;PRO B 335;ASP B 352;ALA B 353;GLN B 354;PHE B 367;TRP B 385;CYH B 387","None;SAH B 605 (-3.3A);SAH B 605 (-4.1A);SAH B 605 (-3.8A);SAH B 605 (-2.3A);SAH B 605 (-3.5A);None;SAH B 605 (-3.5A);G3A B 606 ( 4.1A);SAH B 605 ( 3.8A)","0.71A","5c8tD-5c8sB:45.9","5c8tB-5c8sB:100.00"]]