SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'G39'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1A4G_A_ZMRA466_1
(NEURAMINIDASE)		 4b7j NEURAMINIDASE
(Influenza
A
virus) 		9 / 12 ARG A 118
GLU A 119
ASP A 151
ARG A 225
GLU A 228
GLU A 277
GLU A 278
ASN A 295
TYR A 402
 G39  A1470 (-3.1A)
G39  A1470 (-3.5A)
G39  A1470 (-3.7A)
G39  A1470 (-4.4A)
None
G39  A1470 (-3.7A)
G39  A1470 (-4.2A)
G39  A1470 ( 3.7A)
G39  A1470 (-4.5A)
 0.68A 1a4gA-4b7jA:
53.0		 1a4gA-4b7jA:
31.19
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1A4G_A_ZMRA466_1
(NEURAMINIDASE)		 4b7j NEURAMINIDASE
(Influenza
A
virus) 		10 / 12 ARG A 118
GLU A 119
ASP A 151
ARG A 225
GLU A 228
GLU A 278
ARG A 293
ASN A 295
ARG A 368
TYR A 402
 G39  A1470 (-3.1A)
G39  A1470 (-3.5A)
G39  A1470 (-3.7A)
G39  A1470 (-4.4A)
None
G39  A1470 (-4.2A)
G39  A1470 (-2.9A)
G39  A1470 ( 3.7A)
G39  A1470 (-3.0A)
G39  A1470 (-4.5A)
 0.46A 1a4gA-4b7jA:
53.0		 1a4gA-4b7jA:
31.19
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1A4G_A_ZMRA466_1
(NEURAMINIDASE)		 4hzz NEURAMINIDASE
(Influenza
A
virus) 		9 / 12 ARG A 118
GLU A 119
ASP A 151
ARG A 224
GLU A 227
ALA A 246
GLU A 276
GLU A 277
TYR A 406
 G39  A 509 (-3.0A)
G39  A 509 (-3.3A)
G39  A 509 (-3.6A)
G39  A 509 (-4.7A)
None
G39  A 509 ( 4.1A)
G39  A 509 ( 4.1A)
G39  A 509 ( 4.0A)
G39  A 509 (-4.6A)
 0.65A 1a4gA-4hzzA:
52.3		 1a4gA-4hzzA:
33.91
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1A4G_A_ZMRA466_1
(NEURAMINIDASE)		 4hzz NEURAMINIDASE
(Influenza
A
virus) 		10 / 12 ARG A 118
GLU A 119
ASP A 151
ARG A 224
GLU A 227
ALA A 246
GLU A 277
ARG A 292
ARG A 371
TYR A 406
 G39  A 509 (-3.0A)
G39  A 509 (-3.3A)
G39  A 509 (-3.6A)
G39  A 509 (-4.7A)
None
G39  A 509 ( 4.1A)
G39  A 509 ( 4.0A)
G39  A 509 (-2.8A)
G39  A 509 (-2.9A)
G39  A 509 (-4.6A)
 0.47A 1a4gA-4hzzA:
52.3		 1a4gA-4hzzA:
33.91
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1A4G_A_ZMRA466_1
(NEURAMINIDASE)		 4hzz NEURAMINIDASE
(Influenza
A
virus) 		7 / 12 GLU A 119
ARG A 224
GLU A 227
GLU A 276
GLU A 277
ASN A 294
TYR A 406
 G39  A 509 (-3.3A)
G39  A 509 (-4.7A)
None
G39  A 509 ( 4.1A)
G39  A 509 ( 4.0A)
G39  A 509 ( 4.4A)
G39  A 509 (-4.6A)
 1.06A 1a4gA-4hzzA:
52.3		 1a4gA-4hzzA:
33.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4G_A_ZMRA466_1
(NEURAMINIDASE)		 4yw5 NEURAMINIDASE C
(Streptococcus
pneumoniae) 		6 / 12 ARG A 290
ASP A 315
GLU A 584
ARG A 600
ARG A 662
TYR A 695
 G39  A 801 (-2.6A)
G39  A 801 (-3.2A)
G39  A 801 ( 4.7A)
G39  A 801 (-2.9A)
G39  A 801 (-2.9A)
G39  A 801 (-4.4A)
 0.71A 1a4gA-4yw5A:
23.8		 1a4gA-4yw5A:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4G_A_ZMRA466_1
(NEURAMINIDASE)		 6eks SIALIDASE
(Vibrio
cholerae) 		6 / 12 ARG A 250
ASP A 276
GLU A 645
ARG A 661
ARG A 738
TYR A 766
 G39  A 908 (-2.8A)
G39  A 908 (-3.3A)
G39  A 908 (-4.0A)
G39  A 908 (-2.8A)
G39  A 908 (-3.0A)
G39  A 908 (-4.6A)
 0.39A 1a4gA-6eksA:
13.8		 1a4gA-6eksA:
19.12
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1A4G_A_ZMRA466_2
(NEURAMINIDASE)		 4hzz NEURAMINIDASE
(Influenza
A
virus) 		4 / 4 ARG A 152
ARG A 156
TRP A 178
ILE A 222
 G39  A 509 (-3.9A)
None
None
G39  A 509 ( 4.1A)
 0.16A 1a4gA-4hzzA:
52.3		 1a4gA-4hzzA:
33.91
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1A4G_B_ZMRB466_1
(NEURAMINIDASE)		 4b7j NEURAMINIDASE
(Influenza
A
virus) 		11 / 12 ARG A 118
GLU A 119
ARG A 156
ARG A 225
GLU A 228
GLU A 277
GLU A 278
ARG A 293
ASN A 295
ARG A 368
TYR A 402
 G39  A1470 (-3.1A)
G39  A1470 (-3.5A)
None
G39  A1470 (-4.4A)
None
G39  A1470 (-3.7A)
G39  A1470 (-4.2A)
G39  A1470 (-2.9A)
G39  A1470 ( 3.7A)
G39  A1470 (-3.0A)
G39  A1470 (-4.5A)
 0.66A 1a4gB-4b7jA:
53.0		 1a4gB-4b7jA:
31.19
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1A4G_B_ZMRB466_1
(NEURAMINIDASE)		 4hzz NEURAMINIDASE
(Influenza
A
virus) 		9 / 12 ARG A 118
GLU A 119
ARG A 156
ARG A 224
GLU A 227
ALA A 246
GLU A 276
GLU A 277
TYR A 406
 G39  A 509 (-3.0A)
G39  A 509 (-3.3A)
None
G39  A 509 (-4.7A)
None
G39  A 509 ( 4.1A)
G39  A 509 ( 4.1A)
G39  A 509 ( 4.0A)
G39  A 509 (-4.6A)
 0.67A 1a4gB-4hzzA:
52.2		 1a4gB-4hzzA:
33.91
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1A4G_B_ZMRB466_1
(NEURAMINIDASE)		 4hzz NEURAMINIDASE
(Influenza
A
virus) 		10 / 12 ARG A 118
GLU A 119
ARG A 156
ARG A 224
GLU A 227
ALA A 246
GLU A 277
ARG A 292
ARG A 371
TYR A 406
 G39  A 509 (-3.0A)
G39  A 509 (-3.3A)
None
G39  A 509 (-4.7A)
None
G39  A 509 ( 4.1A)
G39  A 509 ( 4.0A)
G39  A 509 (-2.8A)
G39  A 509 (-2.9A)
G39  A 509 (-4.6A)
 0.52A 1a4gB-4hzzA:
52.2		 1a4gB-4hzzA:
33.91
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1A4G_B_ZMRB466_1
(NEURAMINIDASE)		 4hzz NEURAMINIDASE
(Influenza
A
virus) 		8 / 12 GLU A 119
ARG A 156
ARG A 224
GLU A 227
GLU A 276
GLU A 277
ASN A 294
TYR A 406
 G39  A 509 (-3.3A)
None
G39  A 509 (-4.7A)
None
G39  A 509 ( 4.1A)
G39  A 509 ( 4.0A)
G39  A 509 ( 4.4A)
G39  A 509 (-4.6A)
 1.03A 1a4gB-4hzzA:
52.2		 1a4gB-4hzzA:
33.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4G_B_ZMRB466_1
(NEURAMINIDASE)		 4yw5 NEURAMINIDASE C
(Streptococcus
pneumoniae) 		5 / 12 ARG A 290
GLU A 584
ARG A 600
ARG A 662
TYR A 695
 G39  A 801 (-2.6A)
G39  A 801 ( 4.7A)
G39  A 801 (-2.9A)
G39  A 801 (-2.9A)
G39  A 801 (-4.4A)
 0.41A 1a4gB-4yw5A:
23.9		 1a4gB-4yw5A:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4G_B_ZMRB466_1
(NEURAMINIDASE)		 6eks SIALIDASE
(Vibrio
cholerae) 		5 / 12 ARG A 250
GLU A 645
ARG A 661
ARG A 738
TYR A 766
 G39  A 908 (-2.8A)
G39  A 908 (-4.0A)
G39  A 908 (-2.8A)
G39  A 908 (-3.0A)
G39  A 908 (-4.6A)
 0.34A 1a4gB-6eksA:
13.6		 1a4gB-6eksA:
19.12
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1A4G_B_ZMRB466_2
(NEURAMINIDASE)		 4hzz NEURAMINIDASE
(Influenza
A
virus) 		3 / 3 ASP A 151
ARG A 152
ILE A 222
 G39  A 509 (-3.6A)
G39  A 509 (-3.9A)
G39  A 509 ( 4.1A)
 0.19A 1a4gB-4hzzA:
52.2		 1a4gB-4hzzA:
33.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1F9G_A_ASCA950_0
(HYALURONATE LYASE)		 4b7j NEURAMINIDASE
(Influenza
A
virus) 		4 / 7 ARG A 152
ASN A 295
ARG A 368
ARG A 118
 G39  A1470 (-3.9A)
G39  A1470 ( 3.7A)
G39  A1470 (-3.0A)
G39  A1470 (-3.1A)
 1.40A 1f9gA-4b7jA:
undetectable		 1f9gA-4b7jA:
19.87
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1L7F_A_BCZA801_0
(NEURAMINIDASE)		 4b7j NEURAMINIDASE
(Influenza
A
virus) 		11 / 12 GLU A 119
LEU A 134
ASP A 151
ARG A 156
TRP A 179
ARG A 225
GLU A 228
GLU A 277
GLU A 278
ARG A 293
TYR A 402
 G39  A1470 (-3.5A)
None
G39  A1470 (-3.7A)
None
None
G39  A1470 (-4.4A)
None
G39  A1470 (-3.7A)
G39  A1470 (-4.2A)
G39  A1470 (-2.9A)
G39  A1470 (-4.5A)
 0.42A 1l7fA-4b7jA:
64.5		 1l7fA-4b7jA:
40.98
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1L7F_A_BCZA801_0
(NEURAMINIDASE)		 4hzz NEURAMINIDASE
(Influenza
A
virus) 		12 / 12 GLU A 119
LEU A 134
ASP A 151
ARG A 156
TRP A 178
ILE A 222
ARG A 224
GLU A 227
GLU A 276
GLU A 277
ARG A 292
TYR A 406
 G39  A 509 (-3.3A)
None
G39  A 509 (-3.6A)
None
None
G39  A 509 ( 4.1A)
G39  A 509 (-4.7A)
None
G39  A 509 ( 4.1A)
G39  A 509 ( 4.0A)
G39  A 509 (-2.8A)
G39  A 509 (-4.6A)
 0.21A 1l7fA-4hzzA:
63.2		 1l7fA-4hzzA:
48.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1L7F_A_BCZA801_0
(NEURAMINIDASE)		 6eks SIALIDASE
(Vibrio
cholerae) 		5 / 12 ASP A 276
TRP A 337
GLU A 645
ARG A 661
TYR A 766
 G39  A 908 (-3.3A)
None
G39  A 908 (-4.0A)
G39  A 908 (-2.8A)
G39  A 908 (-4.6A)
 0.60A 1l7fA-6eksA:
20.8		 1l7fA-6eksA:
17.48
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1L7F_A_BCZA801_1
(NEURAMINIDASE)		 4b7j NEURAMINIDASE
(Influenza
A
virus) 		3 / 3 ARG A 118
ARG A 152
ARG A 368
 G39  A1470 (-3.1A)
G39  A1470 (-3.9A)
G39  A1470 (-3.0A)
 0.20A 1l7fA-4b7jA:
64.5		 1l7fA-4b7jA:
40.98
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1L7F_A_BCZA801_1
(NEURAMINIDASE)		 4hzz NEURAMINIDASE
(Influenza
A
virus) 		3 / 3 ARG A 118
ARG A 152
ARG A 371
 G39  A 509 (-3.0A)
G39  A 509 (-3.9A)
G39  A 509 (-2.9A)
 0.19A 1l7fA-4hzzA:
63.2		 1l7fA-4hzzA:
48.48
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1L7G_A_BCZA801_0
(NEURAMINIDASE)		 4b7j NEURAMINIDASE
(Influenza
A
virus) 		11 / 12 LEU A 134
ASP A 151
ARG A 152
ARG A 156
TRP A 179
ARG A 225
GLU A 228
GLU A 277
GLU A 278
ARG A 293
TYR A 402
 None
G39  A1470 (-3.7A)
G39  A1470 (-3.9A)
None
None
G39  A1470 (-4.4A)
None
G39  A1470 (-3.7A)
G39  A1470 (-4.2A)
G39  A1470 (-2.9A)
G39  A1470 (-4.5A)
 0.28A 1l7gA-4b7jA:
64.4		 1l7gA-4b7jA:
40.76
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1L7G_A_BCZA801_0
(NEURAMINIDASE)		 4hzz NEURAMINIDASE
(Influenza
A
virus) 		12 / 12 LEU A 134
ASP A 151
ARG A 152
ARG A 156
TRP A 178
ILE A 222
ARG A 224
GLU A 227
GLU A 276
GLU A 277
ARG A 292
TYR A 406
 None
G39  A 509 (-3.6A)
G39  A 509 (-3.9A)
None
None
G39  A 509 ( 4.1A)
G39  A 509 (-4.7A)
None
G39  A 509 ( 4.1A)
G39  A 509 ( 4.0A)
G39  A 509 (-2.8A)
G39  A 509 (-4.6A)
 0.21A 1l7gA-4hzzA:
63.1		 1l7gA-4hzzA:
48.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1L7G_A_BCZA801_0
(NEURAMINIDASE)		 6eks SIALIDASE
(Vibrio
cholerae) 		5 / 12 ASP A 276
TRP A 337
GLU A 645
ARG A 661
TYR A 766
 G39  A 908 (-3.3A)
None
G39  A 908 (-4.0A)
G39  A 908 (-2.8A)
G39  A 908 (-4.6A)
 0.58A 1l7gA-6eksA:
20.7		 1l7gA-6eksA:
17.48
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1L7H_A_BCZA801_0
(NEURAMINIDASE)		 4b7j NEURAMINIDASE
(Influenza
A
virus) 		10 / 12 GLU A 119
LEU A 134
ASP A 151
ARG A 156
TRP A 179
ARG A 225
GLU A 228
GLU A 277
GLU A 278
TYR A 402
 G39  A1470 (-3.5A)
None
G39  A1470 (-3.7A)
None
None
G39  A1470 (-4.4A)
None
G39  A1470 (-3.7A)
G39  A1470 (-4.2A)
G39  A1470 (-4.5A)
 0.44A 1l7hA-4b7jA:
64.4		 1l7hA-4b7jA:
40.76
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1L7H_A_BCZA801_0
(NEURAMINIDASE)		 4hzz NEURAMINIDASE
(Influenza
A
virus) 		11 / 12 GLU A 119
LEU A 134
ASP A 151
ARG A 156
TRP A 178
ILE A 222
ARG A 224
GLU A 227
GLU A 276
GLU A 277
TYR A 406
 G39  A 509 (-3.3A)
None
G39  A 509 (-3.6A)
None
None
G39  A 509 ( 4.1A)
G39  A 509 (-4.7A)
None
G39  A 509 ( 4.1A)
G39  A 509 ( 4.0A)
G39  A 509 (-4.6A)
 0.19A 1l7hA-4hzzA:
63.2		 1l7hA-4hzzA:
48.22
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1L7H_A_BCZA801_1
(NEURAMINIDASE)		 4b7j NEURAMINIDASE
(Influenza
A
virus) 		3 / 3 ARG A 118
ARG A 152
ARG A 368
 G39  A1470 (-3.1A)
G39  A1470 (-3.9A)
G39  A1470 (-3.0A)
 0.21A 1l7hA-4b7jA:
64.4		 1l7hA-4b7jA:
40.76
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1L7H_A_BCZA801_1
(NEURAMINIDASE)		 4hzz NEURAMINIDASE
(Influenza
A
virus) 		3 / 3 ARG A 118
ARG A 152
ARG A 371
 G39  A 509 (-3.0A)
G39  A 509 (-3.9A)
G39  A 509 (-2.9A)
 0.17A 1l7hA-4hzzA:
63.2		 1l7hA-4hzzA:
48.22
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1NNC_A_ZMRA479_1
(NEURAMINIDASE N9)		 4b7j NEURAMINIDASE
(Influenza
A
virus) 		11 / 12 ARG A 118
GLU A 119
ARG A 152
ARG A 225
GLU A 228
GLU A 277
GLU A 278
ARG A 293
ASN A 295
ARG A 368
TYR A 402
 G39  A1470 (-3.1A)
G39  A1470 (-3.5A)
G39  A1470 (-3.9A)
G39  A1470 (-4.4A)
None
G39  A1470 (-3.7A)
G39  A1470 (-4.2A)
G39  A1470 (-2.9A)
G39  A1470 ( 3.7A)
G39  A1470 (-3.0A)
G39  A1470 (-4.5A)
 0.60A 1nncA-4b7jA:
64.0		 1nncA-4b7jA:
40.98
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1NNC_A_ZMRA479_1
(NEURAMINIDASE N9)		 4b7j NEURAMINIDASE
(Influenza
A
virus) 		6 / 12 ARG A 223
GLU A 228
GLU A 278
ARG A 293
ARG A 368
TYR A 402
 G39  A1470 (-4.0A)
None
G39  A1470 (-4.2A)
G39  A1470 (-2.9A)
G39  A1470 (-3.0A)
G39  A1470 (-4.5A)
 1.14A 1nncA-4b7jA:
64.0		 1nncA-4b7jA:
40.98
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1NNC_A_ZMRA479_1
(NEURAMINIDASE N9)		 4hzz NEURAMINIDASE
(Influenza
A
virus) 		10 / 12 ARG A 118
GLU A 119
ARG A 152
ARG A 224
GLU A 227
ALA A 246
GLU A 276
GLU A 277
ARG A 371
TYR A 406
 G39  A 509 (-3.0A)
G39  A 509 (-3.3A)
G39  A 509 (-3.9A)
G39  A 509 (-4.7A)
None
G39  A 509 ( 4.1A)
G39  A 509 ( 4.1A)
G39  A 509 ( 4.0A)
G39  A 509 (-2.9A)
G39  A 509 (-4.6A)
 0.62A 1nncA-4hzzA:
62.7		 1nncA-4hzzA:
48.48
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1NNC_A_ZMRA479_1
(NEURAMINIDASE N9)		 4hzz NEURAMINIDASE
(Influenza
A
virus) 		10 / 12 ARG A 118
GLU A 119
ARG A 152
ARG A 224
GLU A 227
ALA A 246
GLU A 276
GLU A 277
ASN A 294
TYR A 406
 G39  A 509 (-3.0A)
G39  A 509 (-3.3A)
G39  A 509 (-3.9A)
G39  A 509 (-4.7A)
None
G39  A 509 ( 4.1A)
G39  A 509 ( 4.1A)
G39  A 509 ( 4.0A)
G39  A 509 ( 4.4A)
G39  A 509 (-4.6A)
 0.87A 1nncA-4hzzA:
62.7		 1nncA-4hzzA:
48.48
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1NNC_A_ZMRA479_1
(NEURAMINIDASE N9)		 4hzz NEURAMINIDASE
(Influenza
A
virus) 		10 / 12 ARG A 118
GLU A 119
ARG A 152
ARG A 224
GLU A 227
ALA A 246
GLU A 277
ARG A 292
ARG A 371
TYR A 406
 G39  A 509 (-3.0A)
G39  A 509 (-3.3A)
G39  A 509 (-3.9A)
G39  A 509 (-4.7A)
None
G39  A 509 ( 4.1A)
G39  A 509 ( 4.0A)
G39  A 509 (-2.8A)
G39  A 509 (-2.9A)
G39  A 509 (-4.6A)
 0.45A 1nncA-4hzzA:
62.7		 1nncA-4hzzA:
48.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NNC_A_ZMRA479_1
(NEURAMINIDASE N9)		 4yw5 NEURAMINIDASE C
(Streptococcus
pneumoniae) 		5 / 12 ARG A 290
GLU A 584
ARG A 600
ARG A 662
TYR A 695
 G39  A 801 (-2.6A)
G39  A 801 ( 4.7A)
G39  A 801 (-2.9A)
G39  A 801 (-2.9A)
G39  A 801 (-4.4A)
 0.52A 1nncA-4yw5A:
20.3		 1nncA-4yw5A:
20.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NNC_A_ZMRA479_1
(NEURAMINIDASE N9)		 6eks SIALIDASE
(Vibrio
cholerae) 		5 / 12 ARG A 250
GLU A 645
ARG A 661
ARG A 738
TYR A 766
 G39  A 908 (-2.8A)
G39  A 908 (-4.0A)
G39  A 908 (-2.8A)
G39  A 908 (-3.0A)
G39  A 908 (-4.6A)
 0.39A 1nncA-6eksA:
20.5		 1nncA-6eksA:
17.48
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1NNC_A_ZMRA479_2
(NEURAMINIDASE N9)		 4hzz NEURAMINIDASE
(Influenza
A
virus) 		4 / 4 ASP A 151
ARG A 156
TRP A 178
ILE A 222
 G39  A 509 (-3.6A)
None
None
G39  A 509 ( 4.1A)
 0.15A 1nncA-4hzzA:
62.7		 1nncA-4hzzA:
48.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V3E_A_ZMRA1200_1
(HEMAGGLUTININ-NEURAM
INIDASE GLYCOPROTEIN)		 4yw5 NEURAMINIDASE C
(Streptococcus
pneumoniae) 		5 / 10 TYR A 533
TYR A 553
GLU A 584
ARG A 600
ARG A 662
 G39  A 801 (-4.5A)
None
G39  A 801 ( 4.7A)
G39  A 801 (-2.9A)
G39  A 801 (-2.9A)
 0.69A 1v3eA-4yw5A:
4.6		 1v3eA-4yw5A:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V3E_A_ZMRA1200_1
(HEMAGGLUTININ-NEURAM
INIDASE GLYCOPROTEIN)		 4yw5 NEURAMINIDASE C
(Streptococcus
pneumoniae) 		5 / 10 TYR A 553
PHE A 396
GLU A 584
ARG A 600
ARG A 662
 None
G39  A 801 (-3.9A)
G39  A 801 ( 4.7A)
G39  A 801 (-2.9A)
G39  A 801 (-2.9A)
 1.06A 1v3eA-4yw5A:
4.6		 1v3eA-4yw5A:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V3E_B_ZMRB2200_1
(HEMAGGLUTININ-NEURAM
INIDASE GLYCOPROTEIN)		 4yw5 NEURAMINIDASE C
(Streptococcus
pneumoniae) 		5 / 10 ARG A 290
TYR A 533
TYR A 553
GLU A 584
ARG A 600
 G39  A 801 (-2.6A)
G39  A 801 (-4.5A)
None
G39  A 801 ( 4.7A)
G39  A 801 (-2.9A)
 1.04A 1v3eB-4yw5A:
7.7		 1v3eB-4yw5A:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V3E_B_ZMRB2200_1
(HEMAGGLUTININ-NEURAM
INIDASE GLYCOPROTEIN)		 4yw5 NEURAMINIDASE C
(Streptococcus
pneumoniae) 		5 / 10 ARG A 290
TYR A 533
TYR A 553
GLU A 584
TYR A 695
 G39  A 801 (-2.6A)
G39  A 801 (-4.5A)
None
G39  A 801 ( 4.7A)
G39  A 801 (-4.4A)
 0.96A 1v3eB-4yw5A:
7.7		 1v3eB-4yw5A:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V3E_B_ZMRB2200_1
(HEMAGGLUTININ-NEURAM
INIDASE GLYCOPROTEIN)		 4yw5 NEURAMINIDASE C
(Streptococcus
pneumoniae) 		5 / 10 TYR A 533
TYR A 553
GLU A 584
ARG A 600
ARG A 662
 G39  A 801 (-4.5A)
None
G39  A 801 ( 4.7A)
G39  A 801 (-2.9A)
G39  A 801 (-2.9A)
 0.68A 1v3eB-4yw5A:
7.7		 1v3eB-4yw5A:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V3E_B_ZMRB2200_1
(HEMAGGLUTININ-NEURAM
INIDASE GLYCOPROTEIN)		 4yw5 NEURAMINIDASE C
(Streptococcus
pneumoniae) 		5 / 10 TYR A 553
PHE A 396
GLU A 584
ARG A 600
ARG A 662
 None
G39  A 801 (-3.9A)
G39  A 801 ( 4.7A)
G39  A 801 (-2.9A)
G39  A 801 (-2.9A)
 1.09A 1v3eB-4yw5A:
7.7		 1v3eB-4yw5A:
21.59
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2CML_A_ZMRA1477_1
(NEURAMINIDASE)		 4b7j NEURAMINIDASE
(Influenza
A
virus) 		10 / 12 ARG A 118
GLU A 119
ASP A 151
ARG A 225
GLU A 228
GLU A 277
GLU A 278
ARG A 293
ARG A 368
TYR A 402
 G39  A1470 (-3.1A)
G39  A1470 (-3.5A)
G39  A1470 (-3.7A)
G39  A1470 (-4.4A)
None
G39  A1470 (-3.7A)
G39  A1470 (-4.2A)
G39  A1470 (-2.9A)
G39  A1470 (-3.0A)
G39  A1470 (-4.5A)
 0.65A 2cmlA-4b7jA:
64.2		 2cmlA-4b7jA:
38.77
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2CML_A_ZMRA1477_1
(NEURAMINIDASE)		 4b7j NEURAMINIDASE
(Influenza
A
virus) 		10 / 12 ARG A 118
GLU A 119
ASP A 151
ARG A 225
GLU A 228
GLU A 278
ARG A 293
ASN A 295
ARG A 368
TYR A 402
 G39  A1470 (-3.1A)
G39  A1470 (-3.5A)
G39  A1470 (-3.7A)
G39  A1470 (-4.4A)
None
G39  A1470 (-4.2A)
G39  A1470 (-2.9A)
G39  A1470 ( 3.7A)
G39  A1470 (-3.0A)
G39  A1470 (-4.5A)
 0.47A 2cmlA-4b7jA:
64.2		 2cmlA-4b7jA:
38.77
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2CML_A_ZMRA1477_1
(NEURAMINIDASE)		 4hzz NEURAMINIDASE
(Influenza
A
virus) 		9 / 12 ARG A 118
GLU A 119
ASP A 151
ARG A 224
GLU A 227
ALA A 246
GLU A 276
GLU A 277
TYR A 406
 G39  A 509 (-3.0A)
G39  A 509 (-3.3A)
G39  A 509 (-3.6A)
G39  A 509 (-4.7A)
None
G39  A 509 ( 4.1A)
G39  A 509 ( 4.1A)
G39  A 509 ( 4.0A)
G39  A 509 (-4.6A)
 0.63A 2cmlA-4hzzA:
63.0		 2cmlA-4hzzA:
50.51
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2CML_A_ZMRA1477_1
(NEURAMINIDASE)		 4hzz NEURAMINIDASE
(Influenza
A
virus) 		10 / 12 ARG A 118
GLU A 119
ASP A 151
ARG A 224
GLU A 227
ALA A 246
GLU A 277
ARG A 292
ARG A 371
TYR A 406
 G39  A 509 (-3.0A)
G39  A 509 (-3.3A)
G39  A 509 (-3.6A)
G39  A 509 (-4.7A)
None
G39  A 509 ( 4.1A)
G39  A 509 ( 4.0A)
G39  A 509 (-2.8A)
G39  A 509 (-2.9A)
G39  A 509 (-4.6A)
 0.41A 2cmlA-4hzzA:
63.0		 2cmlA-4hzzA:
50.51
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2CML_A_ZMRA1477_1
(NEURAMINIDASE)		 4hzz NEURAMINIDASE
(Influenza
A
virus) 		9 / 12 GLU A 119
ASP A 151
ARG A 224
GLU A 227
ALA A 246
GLU A 276
GLU A 277
ASN A 294
TYR A 406
 G39  A 509 (-3.3A)
G39  A 509 (-3.6A)
G39  A 509 (-4.7A)
None
G39  A 509 ( 4.1A)
G39  A 509 ( 4.1A)
G39  A 509 ( 4.0A)
G39  A 509 ( 4.4A)
G39  A 509 (-4.6A)
 0.88A 2cmlA-4hzzA:
63.0		 2cmlA-4hzzA:
50.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CML_A_ZMRA1477_1
(NEURAMINIDASE)		 4yw5 NEURAMINIDASE C
(Streptococcus
pneumoniae) 		6 / 12 ARG A 290
ASP A 315
GLU A 584
ARG A 600
ARG A 662
TYR A 695
 G39  A 801 (-2.6A)
G39  A 801 (-3.2A)
G39  A 801 ( 4.7A)
G39  A 801 (-2.9A)
G39  A 801 (-2.9A)
G39  A 801 (-4.4A)
 0.71A 2cmlA-4yw5A:
10.2		 2cmlA-4yw5A:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CML_A_ZMRA1477_1
(NEURAMINIDASE)		 6eks SIALIDASE
(Vibrio
cholerae) 		6 / 12 ARG A 250
ASP A 276
GLU A 645
ARG A 661
ARG A 738
TYR A 766
 G39  A 908 (-2.8A)
G39  A 908 (-3.3A)
G39  A 908 (-4.0A)
G39  A 908 (-2.8A)
G39  A 908 (-3.0A)
G39  A 908 (-4.6A)
 0.44A 2cmlA-6eksA:
20.9		 2cmlA-6eksA:
21.21
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2CML_A_ZMRA1477_2
(NEURAMINIDASE)		 4b7j NEURAMINIDASE
(Influenza
A
virus) 		4 / 5 LEU A 134
ARG A 152
ARG A 156
TRP A 179
 None
G39  A1470 (-3.9A)
None
None
 0.23A 2cmlA-4b7jA:
64.2		 2cmlA-4b7jA:
38.77
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2CML_A_ZMRA1477_2
(NEURAMINIDASE)		 4hzz NEURAMINIDASE
(Influenza
A
virus) 		5 / 5 LEU A 134
ARG A 152
ARG A 156
TRP A 178
ILE A 222
 None
G39  A 509 (-3.9A)
None
None
G39  A 509 ( 4.1A)
 0.15A 2cmlA-4hzzA:
63.0		 2cmlA-4hzzA:
50.51
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2CML_B_ZMRB2477_1
(NEURAMINIDASE)		 4b7j NEURAMINIDASE
(Influenza
A
virus) 		11 / 12 ARG A 118
GLU A 119
ASP A 151
ARG A 225
GLU A 228
GLU A 277
GLU A 278
ARG A 293
ASN A 295
ARG A 368
TYR A 402
 G39  A1470 (-3.1A)
G39  A1470 (-3.5A)
G39  A1470 (-3.7A)
G39  A1470 (-4.4A)
None
G39  A1470 (-3.7A)
G39  A1470 (-4.2A)
G39  A1470 (-2.9A)
G39  A1470 ( 3.7A)
G39  A1470 (-3.0A)
G39  A1470 (-4.5A)
 0.58A 2cmlB-4b7jA:
64.1		 2cmlB-4b7jA:
38.77
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2CML_B_ZMRB2477_1
(NEURAMINIDASE)		 4hzz NEURAMINIDASE
(Influenza
A
virus) 		10 / 12 ARG A 118
GLU A 119
ASP A 151
ARG A 224
GLU A 227
ALA A 246
GLU A 276
GLU A 277
ARG A 371
TYR A 406
 G39  A 509 (-3.0A)
G39  A 509 (-3.3A)
G39  A 509 (-3.6A)
G39  A 509 (-4.7A)
None
G39  A 509 ( 4.1A)
G39  A 509 ( 4.1A)
G39  A 509 ( 4.0A)
G39  A 509 (-2.9A)
G39  A 509 (-4.6A)
 0.55A 2cmlB-4hzzA:
62.8		 2cmlB-4hzzA:
50.51
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2CML_B_ZMRB2477_1
(NEURAMINIDASE)		 4hzz NEURAMINIDASE
(Influenza
A
virus) 		10 / 12 ARG A 118
GLU A 119
ASP A 151
ARG A 224
GLU A 227
ALA A 246
GLU A 277
ARG A 292
ARG A 371
TYR A 406
 G39  A 509 (-3.0A)
G39  A 509 (-3.3A)
G39  A 509 (-3.6A)
G39  A 509 (-4.7A)
None
G39  A 509 ( 4.1A)
G39  A 509 ( 4.0A)
G39  A 509 (-2.8A)
G39  A 509 (-2.9A)
G39  A 509 (-4.6A)
 0.38A 2cmlB-4hzzA:
62.8		 2cmlB-4hzzA:
50.51
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2CML_B_ZMRB2477_1
(NEURAMINIDASE)		 4hzz NEURAMINIDASE
(Influenza
A
virus) 		9 / 12 GLU A 119
ASP A 151
ARG A 224
GLU A 227
ALA A 246
GLU A 276
GLU A 277
ASN A 294
TYR A 406
 G39  A 509 (-3.3A)
G39  A 509 (-3.6A)
G39  A 509 (-4.7A)
None
G39  A 509 ( 4.1A)
G39  A 509 ( 4.1A)
G39  A 509 ( 4.0A)
G39  A 509 ( 4.4A)
G39  A 509 (-4.6A)
 0.85A 2cmlB-4hzzA:
62.8		 2cmlB-4hzzA:
50.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CML_B_ZMRB2477_1
(NEURAMINIDASE)		 4yw5 NEURAMINIDASE C
(Streptococcus
pneumoniae) 		6 / 12 ARG A 290
ASP A 315
GLU A 584
ARG A 600
ARG A 662
TYR A 695
 G39  A 801 (-2.6A)
G39  A 801 (-3.2A)
G39  A 801 ( 4.7A)
G39  A 801 (-2.9A)
G39  A 801 (-2.9A)
G39  A 801 (-4.4A)
 0.71A 2cmlB-4yw5A:
4.5		 2cmlB-4yw5A:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CML_B_ZMRB2477_1
(NEURAMINIDASE)		 6eks SIALIDASE
(Vibrio
cholerae) 		6 / 12 ARG A 250
ASP A 276
GLU A 645
ARG A 661
ARG A 738
TYR A 766
 G39  A 908 (-2.8A)
G39  A 908 (-3.3A)
G39  A 908 (-4.0A)
G39  A 908 (-2.8A)
G39  A 908 (-3.0A)
G39  A 908 (-4.6A)
 0.45A 2cmlB-6eksA:
10.1		 2cmlB-6eksA:
21.21
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2CML_B_ZMRB2477_2
(NEURAMINIDASE)		 4b7j NEURAMINIDASE
(Influenza
A
virus) 		4 / 5 LEU A 134
ARG A 152
ARG A 156
TRP A 179
 None
G39  A1470 (-3.9A)
None
None
 0.27A 2cmlB-4b7jA:
64.1		 2cmlB-4b7jA:
38.77
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2CML_B_ZMRB2477_2
(NEURAMINIDASE)		 4hzz NEURAMINIDASE
(Influenza
A
virus) 		5 / 5 LEU A 134
ARG A 152
ARG A 156
TRP A 178
ILE A 222
 None
G39  A 509 (-3.9A)
None
None
G39  A 509 ( 4.1A)
 0.18A 2cmlB-4hzzA:
62.8		 2cmlB-4hzzA:
50.51
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2CML_C_ZMRC3477_1
(NEURAMINIDASE)		 4b7j NEURAMINIDASE
(Influenza
A
virus) 		10 / 12 ARG A 118
GLU A 119
ASP A 151
ARG A 225
GLU A 228
GLU A 277
GLU A 278
ARG A 293
ARG A 368
TYR A 402
 G39  A1470 (-3.1A)
G39  A1470 (-3.5A)
G39  A1470 (-3.7A)
G39  A1470 (-4.4A)
None
G39  A1470 (-3.7A)
G39  A1470 (-4.2A)
G39  A1470 (-2.9A)
G39  A1470 (-3.0A)
G39  A1470 (-4.5A)
 0.63A 2cmlC-4b7jA:
64.1		 2cmlC-4b7jA:
38.77
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2CML_C_ZMRC3477_1
(NEURAMINIDASE)		 4b7j NEURAMINIDASE
(Influenza
A
virus) 		10 / 12 ARG A 118
GLU A 119
ASP A 151
ARG A 225
GLU A 228
GLU A 278
ARG A 293
ASN A 295
ARG A 368
TYR A 402
 G39  A1470 (-3.1A)
G39  A1470 (-3.5A)
G39  A1470 (-3.7A)
G39  A1470 (-4.4A)
None
G39  A1470 (-4.2A)
G39  A1470 (-2.9A)
G39  A1470 ( 3.7A)
G39  A1470 (-3.0A)
G39  A1470 (-4.5A)
 0.49A 2cmlC-4b7jA:
64.1		 2cmlC-4b7jA:
38.77
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2CML_C_ZMRC3477_1
(NEURAMINIDASE)		 4hzz NEURAMINIDASE
(Influenza
A
virus) 		10 / 12 ARG A 118
GLU A 119
ASP A 151
ARG A 224
GLU A 227
ALA A 246
GLU A 276
GLU A 277
ARG A 371
TYR A 406
 G39  A 509 (-3.0A)
G39  A 509 (-3.3A)
G39  A 509 (-3.6A)
G39  A 509 (-4.7A)
None
G39  A 509 ( 4.1A)
G39  A 509 ( 4.1A)
G39  A 509 ( 4.0A)
G39  A 509 (-2.9A)
G39  A 509 (-4.6A)
 0.59A 2cmlC-4hzzA:
62.9		 2cmlC-4hzzA:
50.51
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2CML_C_ZMRC3477_1
(NEURAMINIDASE)		 4hzz NEURAMINIDASE
(Influenza
A
virus) 		10 / 12 ARG A 118
GLU A 119
ASP A 151
ARG A 224
GLU A 227
ALA A 246
GLU A 277
ARG A 292
ARG A 371
TYR A 406
 G39  A 509 (-3.0A)
G39  A 509 (-3.3A)
G39  A 509 (-3.6A)
G39  A 509 (-4.7A)
None
G39  A 509 ( 4.1A)
G39  A 509 ( 4.0A)
G39  A 509 (-2.8A)
G39  A 509 (-2.9A)
G39  A 509 (-4.6A)
 0.44A 2cmlC-4hzzA:
62.9		 2cmlC-4hzzA:
50.51
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2CML_C_ZMRC3477_1
(NEURAMINIDASE)		 4hzz NEURAMINIDASE
(Influenza
A
virus) 		9 / 12 GLU A 119
ASP A 151
ARG A 224
GLU A 227
ALA A 246
GLU A 276
GLU A 277
ASN A 294
TYR A 406
 G39  A 509 (-3.3A)
G39  A 509 (-3.6A)
G39  A 509 (-4.7A)
None
G39  A 509 ( 4.1A)
G39  A 509 ( 4.1A)
G39  A 509 ( 4.0A)
G39  A 509 ( 4.4A)
G39  A 509 (-4.6A)
 0.88A 2cmlC-4hzzA:
62.9		 2cmlC-4hzzA:
50.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CML_C_ZMRC3477_1
(NEURAMINIDASE)		 4yw5 NEURAMINIDASE C
(Streptococcus
pneumoniae) 		6 / 12 ARG A 290
ASP A 315
GLU A 584
ARG A 600
ARG A 662
TYR A 695
 G39  A 801 (-2.6A)
G39  A 801 (-3.2A)
G39  A 801 ( 4.7A)
G39  A 801 (-2.9A)
G39  A 801 (-2.9A)
G39  A 801 (-4.4A)
 0.72A 2cmlC-4yw5A:
2.9		 2cmlC-4yw5A:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CML_C_ZMRC3477_1
(NEURAMINIDASE)		 6eks SIALIDASE
(Vibrio
cholerae) 		6 / 12 ARG A 250
ASP A 276
GLU A 645
ARG A 661
ARG A 738
TYR A 766
 G39  A 908 (-2.8A)
G39  A 908 (-3.3A)
G39  A 908 (-4.0A)
G39  A 908 (-2.8A)
G39  A 908 (-3.0A)
G39  A 908 (-4.6A)
 0.43A 2cmlC-6eksA:
10.0		 2cmlC-6eksA:
21.21
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2CML_C_ZMRC3477_2
(NEURAMINIDASE)		 4b7j NEURAMINIDASE
(Influenza
A
virus) 		4 / 5 LEU A 134
ARG A 152
ARG A 156
TRP A 179
 None
G39  A1470 (-3.9A)
None
None
 0.31A 2cmlC-4b7jA:
64.1		 2cmlC-4b7jA:
38.77
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2CML_C_ZMRC3477_2
(NEURAMINIDASE)		 4hzz NEURAMINIDASE
(Influenza
A
virus) 		5 / 5 LEU A 134
ARG A 152
ARG A 156
TRP A 178
ILE A 222
 None
G39  A 509 (-3.9A)
None
None
G39  A 509 ( 4.1A)
 0.23A 2cmlC-4hzzA:
62.9		 2cmlC-4hzzA:
50.51
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2CML_D_ZMRD4477_1
(NEURAMINIDASE)		 4b7j NEURAMINIDASE
(Influenza
A
virus) 		11 / 12 ARG A 118
GLU A 119
ASP A 151
ARG A 225
GLU A 228
GLU A 277
GLU A 278
ARG A 293
ASN A 295
ARG A 368
TYR A 402
 G39  A1470 (-3.1A)
G39  A1470 (-3.5A)
G39  A1470 (-3.7A)
G39  A1470 (-4.4A)
None
G39  A1470 (-3.7A)
G39  A1470 (-4.2A)
G39  A1470 (-2.9A)
G39  A1470 ( 3.7A)
G39  A1470 (-3.0A)
G39  A1470 (-4.5A)
 0.61A 2cmlD-4b7jA:
64.1		 2cmlD-4b7jA:
38.77
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2CML_D_ZMRD4477_1
(NEURAMINIDASE)		 4hzz NEURAMINIDASE
(Influenza
A
virus) 		10 / 12 ARG A 118
GLU A 119
ASP A 151
ARG A 224
GLU A 227
ALA A 246
GLU A 276
GLU A 277
ARG A 371
TYR A 406
 G39  A 509 (-3.0A)
G39  A 509 (-3.3A)
G39  A 509 (-3.6A)
G39  A 509 (-4.7A)
None
G39  A 509 ( 4.1A)
G39  A 509 ( 4.1A)
G39  A 509 ( 4.0A)
G39  A 509 (-2.9A)
G39  A 509 (-4.6A)
 0.60A 2cmlD-4hzzA:
62.8		 2cmlD-4hzzA:
50.51
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2CML_D_ZMRD4477_1
(NEURAMINIDASE)		 4hzz NEURAMINIDASE
(Influenza
A
virus) 		10 / 12 ARG A 118
GLU A 119
ASP A 151
ARG A 224
GLU A 227
ALA A 246
GLU A 277
ARG A 292
ARG A 371
TYR A 406
 G39  A 509 (-3.0A)
G39  A 509 (-3.3A)
G39  A 509 (-3.6A)
G39  A 509 (-4.7A)
None
G39  A 509 ( 4.1A)
G39  A 509 ( 4.0A)
G39  A 509 (-2.8A)
G39  A 509 (-2.9A)
G39  A 509 (-4.6A)
 0.41A 2cmlD-4hzzA:
62.8		 2cmlD-4hzzA:
50.51
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2CML_D_ZMRD4477_1
(NEURAMINIDASE)		 4hzz NEURAMINIDASE
(Influenza
A
virus) 		9 / 12 GLU A 119
ASP A 151
ARG A 224
GLU A 227
ALA A 246
GLU A 276
GLU A 277
ASN A 294
TYR A 406
 G39  A 509 (-3.3A)
G39  A 509 (-3.6A)
G39  A 509 (-4.7A)
None
G39  A 509 ( 4.1A)
G39  A 509 ( 4.1A)
G39  A 509 ( 4.0A)
G39  A 509 ( 4.4A)
G39  A 509 (-4.6A)
 0.88A 2cmlD-4hzzA:
62.8		 2cmlD-4hzzA:
50.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CML_D_ZMRD4477_1
(NEURAMINIDASE)		 4yw5 NEURAMINIDASE C
(Streptococcus
pneumoniae) 		6 / 12 ARG A 290
ASP A 315
GLU A 584
ARG A 600
ARG A 662
TYR A 695
 G39  A 801 (-2.6A)
G39  A 801 (-3.2A)
G39  A 801 ( 4.7A)
G39  A 801 (-2.9A)
G39  A 801 (-2.9A)
G39  A 801 (-4.4A)
 0.72A 2cmlD-4yw5A:
20.4		 2cmlD-4yw5A:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CML_D_ZMRD4477_1
(NEURAMINIDASE)		 6eks SIALIDASE
(Vibrio
cholerae) 		6 / 12 ARG A 250
ASP A 276
GLU A 645
ARG A 661
ARG A 738
TYR A 766
 G39  A 908 (-2.8A)
G39  A 908 (-3.3A)
G39  A 908 (-4.0A)
G39  A 908 (-2.8A)
G39  A 908 (-3.0A)
G39  A 908 (-4.6A)
 0.45A 2cmlD-6eksA:
11.6		 2cmlD-6eksA:
21.21
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2CML_D_ZMRD4477_2
(NEURAMINIDASE)		 4b7j NEURAMINIDASE
(Influenza
A
virus) 		4 / 5 LEU A 134
ARG A 152
ARG A 156
TRP A 179
 None
G39  A1470 (-3.9A)
None
None
 0.23A 2cmlD-4b7jA:
64.1		 2cmlD-4b7jA:
38.77
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2CML_D_ZMRD4477_2
(NEURAMINIDASE)		 4hzz NEURAMINIDASE
(Influenza
A
virus) 		5 / 5 LEU A 134
ARG A 152
ARG A 156
TRP A 178
ILE A 222
 None
G39  A 509 (-3.9A)
None
None
G39  A 509 ( 4.1A)
 0.20A 2cmlD-4hzzA:
62.8		 2cmlD-4hzzA:
50.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F0Z_A_ZMRA381_1
(SIALIDASE 2)		 4b7j NEURAMINIDASE
(Influenza
A
virus) 		5 / 12 ARG A 118
GLU A 278
ARG A 293
ARG A 368
TYR A 402
 G39  A1470 (-3.1A)
G39  A1470 (-4.2A)
G39  A1470 (-2.9A)
G39  A1470 (-3.0A)
G39  A1470 (-4.5A)
 0.44A 2f0zA-4b7jA:
21.4		 2f0zA-4b7jA:
23.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F0Z_A_ZMRA381_1
(SIALIDASE 2)		 4b7j NEURAMINIDASE
(Influenza
A
virus) 		5 / 12 ARG A 156
GLU A 278
ARG A 293
ARG A 368
TYR A 402
 None
G39  A1470 (-4.2A)
G39  A1470 (-2.9A)
G39  A1470 (-3.0A)
G39  A1470 (-4.5A)
 1.11A 2f0zA-4b7jA:
21.4		 2f0zA-4b7jA:
23.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F0Z_A_ZMRA381_1
(SIALIDASE 2)		 4hzz NEURAMINIDASE
(Influenza
A
virus) 		5 / 12 ARG A 118
GLU A 277
ARG A 292
ARG A 371
TYR A 406
 G39  A 509 (-3.0A)
G39  A 509 ( 4.0A)
G39  A 509 (-2.8A)
G39  A 509 (-2.9A)
G39  A 509 (-4.6A)
 0.38A 2f0zA-4hzzA:
8.2		 2f0zA-4hzzA:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F0Z_A_ZMRA381_1
(SIALIDASE 2)		 4hzz NEURAMINIDASE
(Influenza
A
virus) 		5 / 12 ARG A 156
GLU A 277
ARG A 292
ARG A 371
TYR A 406
 None
G39  A 509 ( 4.0A)
G39  A 509 (-2.8A)
G39  A 509 (-2.9A)
G39  A 509 (-4.6A)
 1.03A 2f0zA-4hzzA:
8.2		 2f0zA-4hzzA:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F0Z_A_ZMRA381_1
(SIALIDASE 2)		 4yw5 NEURAMINIDASE C
(Streptococcus
pneumoniae) 		6 / 12 ARG A 290
TYR A 553
GLU A 584
ARG A 600
ARG A 662
TYR A 695
 G39  A 801 (-2.6A)
None
G39  A 801 ( 4.7A)
G39  A 801 (-2.9A)
G39  A 801 (-2.9A)
G39  A 801 (-4.4A)
 0.37A 2f0zA-4yw5A:
38.1		 2f0zA-4yw5A:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F0Z_A_ZMRA381_1
(SIALIDASE 2)		 6eks SIALIDASE
(Vibrio
cholerae) 		6 / 12 ARG A 250
GLU A 269
GLU A 645
ARG A 661
ARG A 738
TYR A 766
 G39  A 908 (-2.8A)
G39  A 908 ( 4.7A)
G39  A 908 (-4.0A)
G39  A 908 (-2.8A)
G39  A 908 (-3.0A)
G39  A 908 (-4.6A)
 0.29A 2f0zA-6eksA:
40.4		 2f0zA-6eksA:
19.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F10_A_BCZA382_0
(SIALIDASE 2)		 4b7j NEURAMINIDASE
(Influenza
A
virus) 		5 / 12 ARG A 118
GLU A 278
ARG A 293
ARG A 368
TYR A 402
 G39  A1470 (-3.1A)
G39  A1470 (-4.2A)
G39  A1470 (-2.9A)
G39  A1470 (-3.0A)
G39  A1470 (-4.5A)
 0.47A 2f10A-4b7jA:
9.5		 2f10A-4b7jA:
23.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F10_A_BCZA382_0
(SIALIDASE 2)		 4hzz NEURAMINIDASE
(Influenza
A
virus) 		5 / 12 ARG A 118
GLU A 277
ARG A 292
ARG A 371
TYR A 406
 G39  A 509 (-3.0A)
G39  A 509 ( 4.0A)
G39  A 509 (-2.8A)
G39  A 509 (-2.9A)
G39  A 509 (-4.6A)
 0.40A 2f10A-4hzzA:
8.4		 2f10A-4hzzA:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F10_A_BCZA382_0
(SIALIDASE 2)		 4yw5 NEURAMINIDASE C
(Streptococcus
pneumoniae) 		8 / 12 ARG A 290
ILE A 291
ARG A 309
TYR A 553
GLU A 584
ARG A 600
ARG A 662
TYR A 695
 G39  A 801 (-2.6A)
None
G39  A 801 (-4.3A)
None
G39  A 801 ( 4.7A)
G39  A 801 (-2.9A)
G39  A 801 (-2.9A)
G39  A 801 (-4.4A)
 0.59A 2f10A-4yw5A:
37.2		 2f10A-4yw5A:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F10_A_BCZA382_0
(SIALIDASE 2)		 6eks SIALIDASE
(Vibrio
cholerae) 		8 / 12 ARG A 250
ILE A 251
GLU A 269
ARG A 271
GLU A 645
ARG A 661
ARG A 738
TYR A 766
 G39  A 908 (-2.8A)
G39  A 908 (-4.7A)
G39  A 908 ( 4.7A)
G39  A 908 (-4.2A)
G39  A 908 (-4.0A)
G39  A 908 (-2.8A)
G39  A 908 (-3.0A)
G39  A 908 (-4.6A)
 0.43A 2f10A-6eksA:
39.4		 2f10A-6eksA:
19.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2GVC_B_MMZB501_1
(MONOOXYGENASE)		 6eks SIALIDASE
(Vibrio
cholerae) 		3 / 3 ASN A 571
TYR A 766
SER A 644
 G39  A 908 (-4.5A)
G39  A 908 (-4.6A)
G39  A 908 ( 3.8A)
 0.78A 2gvcB-6eksA:
undetectable		 2gvcB-6eksA:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2GVC_E_MMZE501_1
(MONOOXYGENASE)		 6eks SIALIDASE
(Vibrio
cholerae) 		3 / 3 ASN A 571
TYR A 766
SER A 644
 G39  A 908 (-4.5A)
G39  A 908 (-4.6A)
G39  A 908 ( 3.8A)
 0.78A 2gvcE-6eksA:
undetectable		 2gvcE-6eksA:
20.59
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2HTQ_A_ZMRA472_1
(NEURAMINIDASE)		 4b7j NEURAMINIDASE
(Influenza
A
virus) 		10 / 12 ARG A 118
GLU A 119
ARG A 152
ARG A 156
GLU A 228
GLU A 277
GLU A 278
ARG A 293
ARG A 368
TYR A 402
 G39  A1470 (-3.1A)
G39  A1470 (-3.5A)
G39  A1470 (-3.9A)
None
None
G39  A1470 (-3.7A)
G39  A1470 (-4.2A)
G39  A1470 (-2.9A)
G39  A1470 (-3.0A)
G39  A1470 (-4.5A)
 0.67A 2htqA-4b7jA:
67.2		 2htqA-4b7jA:
53.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2HTQ_A_ZMRA472_1
(NEURAMINIDASE)		 4b7j NEURAMINIDASE
(Influenza
A
virus) 		5 / 12 ARG A 223
GLU A 278
ARG A 293
ARG A 368
TYR A 402
 G39  A1470 (-4.0A)
G39  A1470 (-4.2A)
G39  A1470 (-2.9A)
G39  A1470 (-3.0A)
G39  A1470 (-4.5A)
 1.13A 2htqA-4b7jA:
67.2		 2htqA-4b7jA:
53.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2HTQ_A_ZMRA472_1
(NEURAMINIDASE)		 4hzz NEURAMINIDASE
(Influenza
A
virus) 		11 / 12 ARG A 118
GLU A 119
ARG A 152
ARG A 156
GLU A 227
ALA A 246
GLU A 276
GLU A 277
ARG A 292
ARG A 371
TYR A 406
 G39  A 509 (-3.0A)
G39  A 509 (-3.3A)
G39  A 509 (-3.9A)
None
None
G39  A 509 ( 4.1A)
G39  A 509 ( 4.1A)
G39  A 509 ( 4.0A)
G39  A 509 (-2.8A)
G39  A 509 (-2.9A)
G39  A 509 (-4.6A)
 0.72A 2htqA-4hzzA:
62.3		 2htqA-4hzzA:
45.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HTQ_A_ZMRA472_1
(NEURAMINIDASE)		 4yw5 NEURAMINIDASE C
(Streptococcus
pneumoniae) 		5 / 12 ARG A 290
GLU A 584
ARG A 600
ARG A 662
TYR A 695
 G39  A 801 (-2.6A)
G39  A 801 ( 4.7A)
G39  A 801 (-2.9A)
G39  A 801 (-2.9A)
G39  A 801 (-4.4A)
 0.69A 2htqA-4yw5A:
10.2		 2htqA-4yw5A:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HTQ_A_ZMRA472_1
(NEURAMINIDASE)		 6eks SIALIDASE
(Vibrio
cholerae) 		5 / 12 ARG A 250
GLU A 645
ARG A 661
ARG A 738
TYR A 766
 G39  A 908 (-2.8A)
G39  A 908 (-4.0A)
G39  A 908 (-2.8A)
G39  A 908 (-3.0A)
G39  A 908 (-4.6A)
 0.55A 2htqA-6eksA:
21.3		 2htqA-6eksA:
19.55
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2HTQ_A_ZMRA472_2
(NEURAMINIDASE)		 4hzz NEURAMINIDASE
(Influenza
A
virus) 		4 / 4 ASP A 151
TRP A 178
ILE A 222
ARG A 224
 G39  A 509 (-3.6A)
None
G39  A 509 ( 4.1A)
G39  A 509 (-4.7A)
 0.37A 2htqA-4hzzA:
62.3		 2htqA-4hzzA:
45.98
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2HTU_A_BCZA801_0
(NEURAMINIDASE)		 4b7j NEURAMINIDASE
(Influenza
A
virus) 		10 / 12 GLU A 119
LEU A 134
ARG A 152
ARG A 156
TRP A 179
SER A 180
ARG A 225
GLU A 277
ARG A 293
TYR A 402
 G39  A1470 (-3.5A)
None
G39  A1470 (-3.9A)
None
None
G39  A1470 ( 4.5A)
G39  A1470 (-4.4A)
G39  A1470 (-3.7A)
G39  A1470 (-2.9A)
G39  A1470 (-4.5A)
 0.44A 2htuA-4b7jA:
68.4		 2htuA-4b7jA:
53.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2HTU_A_BCZA801_0
(NEURAMINIDASE)		 4hzz NEURAMINIDASE
(Influenza
A
virus) 		11 / 12 GLU A 119
LEU A 134
ARG A 152
ARG A 156
TRP A 178
SER A 179
ILE A 222
ARG A 224
GLU A 276
ARG A 292
TYR A 406
 G39  A 509 (-3.3A)
None
G39  A 509 (-3.9A)
None
None
G39  A 509 ( 4.5A)
G39  A 509 ( 4.1A)
G39  A 509 (-4.7A)
G39  A 509 ( 4.1A)
G39  A 509 (-2.8A)
G39  A 509 (-4.6A)
 0.36A 2htuA-4hzzA:
63.3		 2htuA-4hzzA:
45.98
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2HTU_A_BCZA801_1
(NEURAMINIDASE)		 4b7j NEURAMINIDASE
(Influenza
A
virus) 		4 / 4 ARG A 118
ASP A 151
GLU A 228
ARG A 368
 G39  A1470 (-3.1A)
G39  A1470 (-3.7A)
None
G39  A1470 (-3.0A)
 0.33A 2htuA-4b7jA:
68.4		 2htuA-4b7jA:
53.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2HTU_A_BCZA801_1
(NEURAMINIDASE)		 4hzz NEURAMINIDASE
(Influenza
A
virus) 		4 / 4 ARG A 118
ASP A 151
GLU A 227
ARG A 371
 G39  A 509 (-3.0A)
G39  A 509 (-3.6A)
None
G39  A 509 (-2.9A)
 0.28A 2htuA-4hzzA:
63.3		 2htuA-4hzzA:
45.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IGT_C_SAMC1003_1
(SAM DEPENDENT
METHYLTRANSFERASE)		 6eks SIALIDASE
(Vibrio
cholerae) 		4 / 4 ASP A 315
ASP A 276
ASP A 285
GLY A 274
 CA  A 904 (-2.1A)
G39  A 908 (-3.3A)
None
None
 1.32A 2igtC-6eksA:
undetectable		 2igtC-6eksA:
20.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OXT_B_SAMB300_1
(NUCLEOSIDE-2'-O-METH
YLTRANSFERASE)		 6eks SIALIDASE
(Vibrio
cholerae) 		4 / 5 SER A 253
GLY A 575
ASP A 373
ASP A 318
 None
CA  A 903 ( 3.9A)
None
G39  A 908 ( 4.2A)
 1.13A 2oxtB-6eksA:
undetectable		 2oxtB-6eksA:
15.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q63_A_1UNA1001_2
(PROTEASE RETROPEPSIN)		 4yw5 NEURAMINIDASE C
(Streptococcus
pneumoniae) 		3 / 3 ARG A 662
ASN A 725
THR A 313
 G39  A 801 (-2.9A)
None
None
 0.83A 2q63A-4yw5A:
undetectable		 2q63A-4yw5A:
10.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7K_B_SALB1305_1
(LYSR-TYPE REGULATORY
PROTEIN)		 4hzz NEURAMINIDASE
(Influenza
A
virus) 		4 / 5 ARG A 224
PRO A 245
GLY A 244
TRP A 218
 G39  A 509 (-4.7A)
None
None
None
 1.33A 2y7kB-4hzzA:
undetectable		 2y7kB-4hzzA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YA7_A_ZMRA1776_1
(NEURAMINIDASE A)		 4yw5 NEURAMINIDASE C
(Streptococcus
pneumoniae) 		5 / 12 ARG A 290
ASP A 307
ILE A 371
ASP A 388
PHE A 316
 G39  A 801 (-2.6A)
None
None
G39  A 801 ( 4.8A)
GOL  A 802 (-4.9A)
 0.83A 2ya7A-4yw5A:
42.9		 2ya7A-4yw5A:
24.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YA7_A_ZMRA1776_1
(NEURAMINIDASE A)		 4yw5 NEURAMINIDASE C
(Streptococcus
pneumoniae) 		6 / 12 ARG A 290
ILE A 291
ASP A 307
ILE A 320
ARG A 662
TYR A 695
 G39  A 801 (-2.6A)
None
None
None
G39  A 801 (-2.9A)
G39  A 801 (-4.4A)
 1.32A 2ya7A-4yw5A:
42.9		 2ya7A-4yw5A:
24.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YA7_A_ZMRA1776_1
(NEURAMINIDASE A)		 4yw5 NEURAMINIDASE C
(Streptococcus
pneumoniae) 		10 / 12 ARG A 290
ILE A 291
ASP A 307
ILE A 371
ASP A 372
ASP A 388
TYR A 553
ARG A 600
ARG A 662
TYR A 695
 G39  A 801 (-2.6A)
None
None
None
G39  A 801 (-2.6A)
G39  A 801 ( 4.8A)
None
G39  A 801 (-2.9A)
G39  A 801 (-2.9A)
G39  A 801 (-4.4A)
 0.38A 2ya7A-4yw5A:
42.9		 2ya7A-4yw5A:
24.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YA7_A_ZMRA1776_1
(NEURAMINIDASE A)		 6eks SIALIDASE
(Vibrio
cholerae) 		6 / 12 ARG A 250
ILE A 251
ASP A 318
ARG A 661
ARG A 738
TYR A 766
 G39  A 908 (-2.8A)
G39  A 908 (-4.7A)
G39  A 908 ( 4.2A)
G39  A 908 (-2.8A)
G39  A 908 (-3.0A)
G39  A 908 (-4.6A)
 0.84A 2ya7A-6eksA:
43.2		 2ya7A-6eksA:
22.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YA7_B_ZMRB1776_1
(NEURAMINIDASE A)		 4yw5 NEURAMINIDASE C
(Streptococcus
pneumoniae) 		6 / 12 ARG A 290
ILE A 291
ASP A 307
ILE A 320
ARG A 662
TYR A 695
 G39  A 801 (-2.6A)
None
None
None
G39  A 801 (-2.9A)
G39  A 801 (-4.4A)
 1.31A 2ya7B-4yw5A:
42.6		 2ya7B-4yw5A:
24.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YA7_B_ZMRB1776_1
(NEURAMINIDASE A)		 4yw5 NEURAMINIDASE C
(Streptococcus
pneumoniae) 		10 / 12 ARG A 290
ILE A 291
ASP A 307
ILE A 371
ASP A 372
ASP A 388
TYR A 553
ARG A 600
ARG A 662
TYR A 695
 G39  A 801 (-2.6A)
None
None
None
G39  A 801 (-2.6A)
G39  A 801 ( 4.8A)
None
G39  A 801 (-2.9A)
G39  A 801 (-2.9A)
G39  A 801 (-4.4A)
 0.36A 2ya7B-4yw5A:
42.6		 2ya7B-4yw5A:
24.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YA7_B_ZMRB1776_1
(NEURAMINIDASE A)		 4yw5 NEURAMINIDASE C
(Streptococcus
pneumoniae) 		6 / 12 ARG A 290
ILE A 291
ASP A 307
ILE A 371
ASP A 388
PHE A 316
 G39  A 801 (-2.6A)
None
None
None
G39  A 801 ( 4.8A)
GOL  A 802 (-4.9A)
 0.78A 2ya7B-4yw5A:
42.6		 2ya7B-4yw5A:
24.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YA7_B_ZMRB1776_1
(NEURAMINIDASE A)		 6eks SIALIDASE
(Vibrio
cholerae) 		6 / 12 ARG A 250
ILE A 251
ASP A 318
ARG A 661
ARG A 738
TYR A 766
 G39  A 908 (-2.8A)
G39  A 908 (-4.7A)
G39  A 908 ( 4.2A)
G39  A 908 (-2.8A)
G39  A 908 (-3.0A)
G39  A 908 (-4.6A)
 0.86A 2ya7B-6eksA:
43.0		 2ya7B-6eksA:
22.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YA7_C_ZMRC1776_1
(NEURAMINIDASE A)		 4yw5 NEURAMINIDASE C
(Streptococcus
pneumoniae) 		5 / 12 ARG A 290
ASP A 307
ILE A 371
ASP A 388
PHE A 316
 G39  A 801 (-2.6A)
None
None
G39  A 801 ( 4.8A)
GOL  A 802 (-4.9A)
 0.83A 2ya7C-4yw5A:
39.6		 2ya7C-4yw5A:
24.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YA7_C_ZMRC1776_1
(NEURAMINIDASE A)		 4yw5 NEURAMINIDASE C
(Streptococcus
pneumoniae) 		6 / 12 ARG A 290
ILE A 291
ASP A 307
ILE A 320
ARG A 662
TYR A 695
 G39  A 801 (-2.6A)
None
None
None
G39  A 801 (-2.9A)
G39  A 801 (-4.4A)
 1.30A 2ya7C-4yw5A:
39.6		 2ya7C-4yw5A:
24.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YA7_C_ZMRC1776_1
(NEURAMINIDASE A)		 4yw5 NEURAMINIDASE C
(Streptococcus
pneumoniae) 		10 / 12 ARG A 290
ILE A 291
ASP A 307
ILE A 371
ASP A 372
ASP A 388
TYR A 553
ARG A 600
ARG A 662
TYR A 695
 G39  A 801 (-2.6A)
None
None
None
G39  A 801 (-2.6A)
G39  A 801 ( 4.8A)
None
G39  A 801 (-2.9A)
G39  A 801 (-2.9A)
G39  A 801 (-4.4A)
 0.36A 2ya7C-4yw5A:
39.6		 2ya7C-4yw5A:
24.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YA7_C_ZMRC1776_1
(NEURAMINIDASE A)		 6eks SIALIDASE
(Vibrio
cholerae) 		6 / 12 ARG A 250
ILE A 251
ASP A 318
ARG A 661
ARG A 738
TYR A 766
 G39  A 908 (-2.8A)
G39  A 908 (-4.7A)
G39  A 908 ( 4.2A)
G39  A 908 (-2.8A)
G39  A 908 (-3.0A)
G39  A 908 (-4.6A)
 0.83A 2ya7C-6eksA:
41.2		 2ya7C-6eksA:
22.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YA7_C_ZMRC1776_1
(NEURAMINIDASE A)		 6eks SIALIDASE
(Vibrio
cholerae) 		6 / 12 ARG A 250
ILE A 251
ASP A 318
LEU A 606
ARG A 738
TYR A 766
 G39  A 908 (-2.8A)
G39  A 908 (-4.7A)
G39  A 908 ( 4.2A)
None
G39  A 908 (-3.0A)
G39  A 908 (-4.6A)
 1.27A 2ya7C-6eksA:
41.2		 2ya7C-6eksA:
22.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YA7_D_ZMRD1776_1
(NEURAMINIDASE A)		 4yw5 NEURAMINIDASE C
(Streptococcus
pneumoniae) 		6 / 12 ARG A 290
ILE A 291
ASP A 307
ILE A 320
ARG A 662
TYR A 695
 G39  A 801 (-2.6A)
None
None
None
G39  A 801 (-2.9A)
G39  A 801 (-4.4A)
 1.31A 2ya7D-4yw5A:
19.6		 2ya7D-4yw5A:
24.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YA7_D_ZMRD1776_1
(NEURAMINIDASE A)		 4yw5 NEURAMINIDASE C
(Streptococcus
pneumoniae) 		10 / 12 ARG A 290
ILE A 291
ASP A 307
ILE A 371
ASP A 372
ASP A 388
TYR A 553
ARG A 600
ARG A 662
TYR A 695
 G39  A 801 (-2.6A)
None
None
None
G39  A 801 (-2.6A)
G39  A 801 ( 4.8A)
None
G39  A 801 (-2.9A)
G39  A 801 (-2.9A)
G39  A 801 (-4.4A)
 0.35A 2ya7D-4yw5A:
19.6		 2ya7D-4yw5A:
24.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YA7_D_ZMRD1776_1
(NEURAMINIDASE A)		 4yw5 NEURAMINIDASE C
(Streptococcus
pneumoniae) 		6 / 12 ARG A 290
ILE A 291
ASP A 307
ILE A 371
ASP A 388
PHE A 316
 G39  A 801 (-2.6A)
None
None
None
G39  A 801 ( 4.8A)
GOL  A 802 (-4.9A)
 0.78A 2ya7D-4yw5A:
19.6		 2ya7D-4yw5A:
24.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YA7_D_ZMRD1776_1
(NEURAMINIDASE A)		 6eks SIALIDASE
(Vibrio
cholerae) 		6 / 12 ARG A 250
ILE A 251
ASP A 318
ARG A 661
ARG A 738
TYR A 766
 G39  A 908 (-2.8A)
G39  A 908 (-4.7A)
G39  A 908 ( 4.2A)
G39  A 908 (-2.8A)
G39  A 908 (-3.0A)
G39  A 908 (-4.6A)
 0.83A 2ya7D-6eksA:
43.0		 2ya7D-6eksA:
22.19
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3B7E_A_ZMRA1001_1
(NEURAMINIDASE)		 4b7j NEURAMINIDASE
(Influenza
A
virus) 		12 / 12 ARG A 118
GLU A 119
ASP A 151
ARG A 225
GLU A 228
SER A 247
GLU A 277
GLU A 278
ARG A 293
ASN A 295
ARG A 368
TYR A 402
 G39  A1470 (-3.1A)
G39  A1470 (-3.5A)
G39  A1470 (-3.7A)
G39  A1470 (-4.4A)
None
G39  A1470 ( 4.3A)
G39  A1470 (-3.7A)
G39  A1470 (-4.2A)
G39  A1470 (-2.9A)
G39  A1470 ( 3.7A)
G39  A1470 (-3.0A)
G39  A1470 (-4.5A)
 0.55A 3b7eA-4b7jA:
74.5		 3b7eA-4b7jA:
82.41
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3B7E_A_ZMRA1001_1
(NEURAMINIDASE)		 4b7j NEURAMINIDASE
(Influenza
A
virus) 		5 / 12 GLU A 228
SER A 247
ARG A 293
ASN A 295
TYR A 402
 None
G39  A1470 ( 4.3A)
G39  A1470 (-2.9A)
G39  A1470 ( 3.7A)
G39  A1470 (-4.5A)
 1.26A 3b7eA-4b7jA:
74.5		 3b7eA-4b7jA:
82.41
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3B7E_A_ZMRA1001_1
(NEURAMINIDASE)		 4hzz NEURAMINIDASE
(Influenza
A
virus) 		9 / 12 ARG A 118
GLU A 119
ASP A 151
ARG A 224
GLU A 227
GLU A 276
GLU A 277
ARG A 371
TYR A 406
 G39  A 509 (-3.0A)
G39  A 509 (-3.3A)
G39  A 509 (-3.6A)
G39  A 509 (-4.7A)
None
G39  A 509 ( 4.1A)
G39  A 509 ( 4.0A)
G39  A 509 (-2.9A)
G39  A 509 (-4.6A)
 0.56A 3b7eA-4hzzA:
63.6		 3b7eA-4hzzA:
46.55
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3B7E_A_ZMRA1001_1
(NEURAMINIDASE)		 4hzz NEURAMINIDASE
(Influenza
A
virus) 		9 / 12 ARG A 118
GLU A 119
ASP A 151
ARG A 224
GLU A 227
GLU A 277
ARG A 292
ARG A 371
TYR A 406
 G39  A 509 (-3.0A)
G39  A 509 (-3.3A)
G39  A 509 (-3.6A)
G39  A 509 (-4.7A)
None
G39  A 509 ( 4.0A)
G39  A 509 (-2.8A)
G39  A 509 (-2.9A)
G39  A 509 (-4.6A)
 0.28A 3b7eA-4hzzA:
63.6		 3b7eA-4hzzA:
46.55
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3B7E_A_ZMRA1001_1
(NEURAMINIDASE)		 4hzz NEURAMINIDASE
(Influenza
A
virus) 		7 / 12 GLU A 119
ARG A 224
GLU A 227
GLU A 276
GLU A 277
ASN A 294
TYR A 406
 G39  A 509 (-3.3A)
G39  A 509 (-4.7A)
None
G39  A 509 ( 4.1A)
G39  A 509 ( 4.0A)
G39  A 509 ( 4.4A)
G39  A 509 (-4.6A)
 0.94A 3b7eA-4hzzA:
63.6		 3b7eA-4hzzA:
46.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B7E_A_ZMRA1001_1
(NEURAMINIDASE)		 4yw5 NEURAMINIDASE C
(Streptococcus
pneumoniae) 		6 / 12 ARG A 290
ASP A 315
GLU A 584
ARG A 600
ARG A 662
TYR A 695
 G39  A 801 (-2.6A)
G39  A 801 (-3.2A)
G39  A 801 ( 4.7A)
G39  A 801 (-2.9A)
G39  A 801 (-2.9A)
G39  A 801 (-4.4A)
 0.80A 3b7eA-4yw5A:
20.4		 3b7eA-4yw5A:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B7E_A_ZMRA1001_1
(NEURAMINIDASE)		 6eks SIALIDASE
(Vibrio
cholerae) 		6 / 12 ARG A 250
ASP A 276
GLU A 645
ARG A 661
ARG A 738
TYR A 766
 G39  A 908 (-2.8A)
G39  A 908 (-3.3A)
G39  A 908 (-4.0A)
G39  A 908 (-2.8A)
G39  A 908 (-3.0A)
G39  A 908 (-4.6A)
 0.47A 3b7eA-6eksA:
20.8		 3b7eA-6eksA:
20.37
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3B7E_A_ZMRA1001_2
(NEURAMINIDASE)		 4hzz NEURAMINIDASE
(Influenza
A
virus) 		4 / 4 ARG A 152
ARG A 156
TRP A 178
ILE A 222
 G39  A 509 (-3.9A)
None
None
G39  A 509 ( 4.1A)
 0.12A 3b7eA-4hzzA:
63.6		 3b7eA-4hzzA:
46.55
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3B7E_B_ZMRB1002_1
(NEURAMINIDASE)		 4b7j NEURAMINIDASE
(Influenza
A
virus) 		12 / 12 ARG A 118
GLU A 119
ASP A 151
ARG A 225
GLU A 228
SER A 247
GLU A 277
GLU A 278
ARG A 293
ASN A 295
ARG A 368
TYR A 402
 G39  A1470 (-3.1A)
G39  A1470 (-3.5A)
G39  A1470 (-3.7A)
G39  A1470 (-4.4A)
None
G39  A1470 ( 4.3A)
G39  A1470 (-3.7A)
G39  A1470 (-4.2A)
G39  A1470 (-2.9A)
G39  A1470 ( 3.7A)
G39  A1470 (-3.0A)
G39  A1470 (-4.5A)
 0.55A 3b7eB-4b7jA:
74.4		 3b7eB-4b7jA:
82.41
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3B7E_B_ZMRB1002_1
(NEURAMINIDASE)		 4hzz NEURAMINIDASE
(Influenza
A
virus) 		9 / 12 ARG A 118
GLU A 119
ASP A 151
ARG A 224
GLU A 227
GLU A 276
GLU A 277
ARG A 371
TYR A 406
 G39  A 509 (-3.0A)
G39  A 509 (-3.3A)
G39  A 509 (-3.6A)
G39  A 509 (-4.7A)
None
G39  A 509 ( 4.1A)
G39  A 509 ( 4.0A)
G39  A 509 (-2.9A)
G39  A 509 (-4.6A)
 0.55A 3b7eB-4hzzA:
63.7		 3b7eB-4hzzA:
46.55
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3B7E_B_ZMRB1002_1
(NEURAMINIDASE)		 4hzz NEURAMINIDASE
(Influenza
A
virus) 		9 / 12 ARG A 118
GLU A 119
ASP A 151
ARG A 224
GLU A 227
GLU A 277
ARG A 292
ARG A 371
TYR A 406
 G39  A 509 (-3.0A)
G39  A 509 (-3.3A)
G39  A 509 (-3.6A)
G39  A 509 (-4.7A)
None
G39  A 509 ( 4.0A)
G39  A 509 (-2.8A)
G39  A 509 (-2.9A)
G39  A 509 (-4.6A)
 0.28A 3b7eB-4hzzA:
63.7		 3b7eB-4hzzA:
46.55
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3B7E_B_ZMRB1002_1
(NEURAMINIDASE)		 4hzz NEURAMINIDASE
(Influenza
A
virus) 		7 / 12 GLU A 119
ARG A 224
GLU A 227
GLU A 276
GLU A 277
ASN A 294
TYR A 406
 G39  A 509 (-3.3A)
G39  A 509 (-4.7A)
None
G39  A 509 ( 4.1A)
G39  A 509 ( 4.0A)
G39  A 509 ( 4.4A)
G39  A 509 (-4.6A)
 0.94A 3b7eB-4hzzA:
63.7		 3b7eB-4hzzA:
46.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B7E_B_ZMRB1002_1
(NEURAMINIDASE)		 4yw5 NEURAMINIDASE C
(Streptococcus
pneumoniae) 		6 / 12 ARG A 290
ASP A 315
GLU A 584
ARG A 600
ARG A 662
TYR A 695
 G39  A 801 (-2.6A)
G39  A 801 (-3.2A)
G39  A 801 ( 4.7A)
G39  A 801 (-2.9A)
G39  A 801 (-2.9A)
G39  A 801 (-4.4A)
 0.80A 3b7eB-4yw5A:
20.8		 3b7eB-4yw5A:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B7E_B_ZMRB1002_1
(NEURAMINIDASE)		 6eks SIALIDASE
(Vibrio
cholerae) 		6 / 12 ARG A 250
ASP A 276
GLU A 645
ARG A 661
ARG A 738
TYR A 766
 G39  A 908 (-2.8A)
G39  A 908 (-3.3A)
G39  A 908 (-4.0A)
G39  A 908 (-2.8A)
G39  A 908 (-3.0A)
G39  A 908 (-4.6A)
 0.48A 3b7eB-6eksA:
20.7		 3b7eB-6eksA:
20.37
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3B7E_B_ZMRB1002_2
(NEURAMINIDASE)		 4hzz NEURAMINIDASE
(Influenza
A
virus) 		4 / 4 ARG A 152
ARG A 156
TRP A 178
ILE A 222
 G39  A 509 (-3.9A)
None
None
G39  A 509 ( 4.1A)
 0.13A 3b7eB-4hzzA:
63.7		 3b7eB-4hzzA:
46.55
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3CKZ_A_ZMRA469_1
(NEURAMINIDASE)		 4b7j NEURAMINIDASE
(Influenza
A
virus) 		9 / 12 ARG A 118
ARG A 152
GLU A 228
GLU A 277
GLU A 278
ARG A 293
ASN A 295
ARG A 368
TYR A 402
 G39  A1470 (-3.1A)
G39  A1470 (-3.9A)
None
G39  A1470 (-3.7A)
G39  A1470 (-4.2A)
G39  A1470 (-2.9A)
G39  A1470 ( 3.7A)
G39  A1470 (-3.0A)
G39  A1470 (-4.5A)
 0.63A 3ckzA-4b7jA:
74.2		 3ckzA-4b7jA:
90.91
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3CKZ_A_ZMRA469_1
(NEURAMINIDASE)		 4b7j NEURAMINIDASE
(Influenza
A
virus) 		9 / 12 ARG A 118
GLU A 119
ARG A 152
GLU A 228
GLU A 278
ARG A 293
ASN A 295
ARG A 368
TYR A 402
 G39  A1470 (-3.1A)
G39  A1470 (-3.5A)
G39  A1470 (-3.9A)
None
G39  A1470 (-4.2A)
G39  A1470 (-2.9A)
G39  A1470 ( 3.7A)
G39  A1470 (-3.0A)
G39  A1470 (-4.5A)
 0.39A 3ckzA-4b7jA:
74.2		 3ckzA-4b7jA:
90.91
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3CKZ_A_ZMRA469_1
(NEURAMINIDASE)		 4b7j NEURAMINIDASE
(Influenza
A
virus) 		6 / 12 ARG A 223
GLU A 228
GLU A 278
ARG A 293
ARG A 368
TYR A 402
 G39  A1470 (-4.0A)
None
G39  A1470 (-4.2A)
G39  A1470 (-2.9A)
G39  A1470 (-3.0A)
G39  A1470 (-4.5A)
 1.06A 3ckzA-4b7jA:
74.2		 3ckzA-4b7jA:
90.91
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3CKZ_A_ZMRA469_1
(NEURAMINIDASE)		 4hzz NEURAMINIDASE
(Influenza
A
virus) 		7 / 12 ARG A 118
GLU A 119
ARG A 152
GLU A 227
GLU A 276
GLU A 277
TYR A 406
 G39  A 509 (-3.0A)
G39  A 509 (-3.3A)
G39  A 509 (-3.9A)
None
G39  A 509 ( 4.1A)
G39  A 509 ( 4.0A)
G39  A 509 (-4.6A)
 0.76A 3ckzA-4hzzA:
63.8		 3ckzA-4hzzA:
46.82
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3CKZ_A_ZMRA469_1
(NEURAMINIDASE)		 4hzz NEURAMINIDASE
(Influenza
A
virus) 		8 / 12 ARG A 118
GLU A 119
ARG A 152
GLU A 227
GLU A 277
ARG A 292
ARG A 371
TYR A 406
 G39  A 509 (-3.0A)
G39  A 509 (-3.3A)
G39  A 509 (-3.9A)
None
G39  A 509 ( 4.0A)
G39  A 509 (-2.8A)
G39  A 509 (-2.9A)
G39  A 509 (-4.6A)
 0.21A 3ckzA-4hzzA:
63.8		 3ckzA-4hzzA:
46.82
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3CKZ_A_ZMRA469_1
(NEURAMINIDASE)		 4hzz NEURAMINIDASE
(Influenza
A
virus) 		7 / 12 GLU A 119
ARG A 152
GLU A 227
GLU A 276
GLU A 277
ASN A 294
TYR A 406
 G39  A 509 (-3.3A)
G39  A 509 (-3.9A)
None
G39  A 509 ( 4.1A)
G39  A 509 ( 4.0A)
G39  A 509 ( 4.4A)
G39  A 509 (-4.6A)
 1.05A 3ckzA-4hzzA:
63.8		 3ckzA-4hzzA:
46.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CKZ_A_ZMRA469_1
(NEURAMINIDASE)		 4yw5 NEURAMINIDASE C
(Streptococcus
pneumoniae) 		5 / 12 ARG A 290
GLU A 584
ARG A 600
ARG A 662
TYR A 695
 G39  A 801 (-2.6A)
G39  A 801 ( 4.7A)
G39  A 801 (-2.9A)
G39  A 801 (-2.9A)
G39  A 801 (-4.4A)
 0.43A 3ckzA-4yw5A:
12.1		 3ckzA-4yw5A:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CKZ_A_ZMRA469_1
(NEURAMINIDASE)		 6eks SIALIDASE
(Vibrio
cholerae) 		5 / 12 ARG A 250
GLU A 645
ARG A 661
ARG A 738
TYR A 766
 G39  A 908 (-2.8A)
G39  A 908 (-4.0A)
G39  A 908 (-2.8A)
G39  A 908 (-3.0A)
G39  A 908 (-4.6A)
 0.32A 3ckzA-6eksA:
21.0		 3ckzA-6eksA:
22.47
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3CKZ_A_ZMRA469_2
(NEURAMINIDASE)		 4b7j NEURAMINIDASE
(Influenza
A
virus) 		5 / 6 ASP A 151
ARG A 156
TRP A 179
ARG A 225
SER A 247
 G39  A1470 (-3.7A)
None
None
G39  A1470 (-4.4A)
G39  A1470 ( 4.3A)
 0.74A 3ckzA-4b7jA:
74.2		 3ckzA-4b7jA:
90.91
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3CKZ_A_ZMRA469_2
(NEURAMINIDASE)		 4hzz NEURAMINIDASE
(Influenza
A
virus) 		5 / 6 ASP A 151
ARG A 156
TRP A 178
ILE A 222
ARG A 224
 G39  A 509 (-3.6A)
None
None
G39  A 509 ( 4.1A)
G39  A 509 (-4.7A)
 0.67A 3ckzA-4hzzA:
63.8		 3ckzA-4hzzA:
46.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HCR_A_CHDA424_0
(FERROCHELATASE,
MITOCHONDRIAL)		 6eks SIALIDASE
(Vibrio
cholerae) 		4 / 8 LEU A 601
ARG A 347
GLY A 278
PRO A 277
 None
None
CA  A 904 ( 4.6A)
G39  A 908 ( 4.4A)
 1.04A 3hcrA-6eksA:
undetectable		 3hcrA-6eksA:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HRD_E_NIOE5660_1
(NICOTINATE
DEHYDROGENASE LARGE
MOLYBDOPTERIN
SUBUNIT
NICOTINATE
DEHYDROGENASE MEDIUM
MOLYBDOPTERIN
SUBUNIT)		 4b7j NEURAMINIDASE
(Influenza
A
virus) 		3 / 3 GLU A 228
GLU A 278
TRP A 423
 None
G39  A1470 (-4.2A)
None
 0.95A 3hrdA-4b7jA:
undetectable
3hrdE-4b7jA:
undetectable
3hrdF-4b7jA:
undetectable		 3hrdA-4b7jA:
19.60
3hrdE-4b7jA:
19.60
3hrdF-4b7jA:
20.59
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3K37_A_BCZA468_0
(NEURAMINIDASE)		 4b7j NEURAMINIDASE
(Influenza
A
virus) 		11 / 12 ARG A 118
GLU A 119
LEU A 134
ARG A 156
TRP A 179
ARG A 225
GLU A 228
GLU A 277
GLU A 278
ARG A 293
TYR A 402
 G39  A1470 (-3.1A)
G39  A1470 (-3.5A)
None
None
None
G39  A1470 (-4.4A)
None
G39  A1470 (-3.7A)
G39  A1470 (-4.2A)
G39  A1470 (-2.9A)
G39  A1470 (-4.5A)
 0.44A 3k37A-4b7jA:
53.2		 3k37A-4b7jA:
33.55
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3K37_A_BCZA468_0
(NEURAMINIDASE)		 4hzz NEURAMINIDASE
(Influenza
A
virus) 		12 / 12 ARG A 118
GLU A 119
LEU A 134
ARG A 156
TRP A 178
ARG A 224
GLU A 227
ALA A 246
GLU A 276
GLU A 277
ARG A 292
TYR A 406
 G39  A 509 (-3.0A)
G39  A 509 (-3.3A)
None
None
None
G39  A 509 (-4.7A)
None
G39  A 509 ( 4.1A)
G39  A 509 ( 4.1A)
G39  A 509 ( 4.0A)
G39  A 509 (-2.8A)
G39  A 509 (-4.6A)
 0.46A 3k37A-4hzzA:
52.4		 3k37A-4hzzA:
34.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K37_A_BCZA468_0
(NEURAMINIDASE)		 6eks SIALIDASE
(Vibrio
cholerae) 		5 / 12 ARG A 250
TRP A 337
GLU A 645
ARG A 661
TYR A 766
 G39  A 908 (-2.8A)
None
G39  A 908 (-4.0A)
G39  A 908 (-2.8A)
G39  A 908 (-4.6A)
 0.58A 3k37A-6eksA:
13.8		 3k37A-6eksA:
19.84
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3K37_A_BCZA468_1
(NEURAMINIDASE)		 4b7j NEURAMINIDASE
(Influenza
A
virus) 		3 / 3 ASP A 151
ARG A 152
ARG A 368
 G39  A1470 (-3.7A)
G39  A1470 (-3.9A)
G39  A1470 (-3.0A)
 0.24A 3k37A-4b7jA:
53.2		 3k37A-4b7jA:
33.55
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3K37_A_BCZA468_1
(NEURAMINIDASE)		 4hzz NEURAMINIDASE
(Influenza
A
virus) 		3 / 3 ASP A 151
ARG A 152
ARG A 371
 G39  A 509 (-3.6A)
G39  A 509 (-3.9A)
G39  A 509 (-2.9A)
 0.23A 3k37A-4hzzA:
52.4		 3k37A-4hzzA:
34.31
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3K37_B_BCZB468_0
(NEURAMINIDASE)		 4b7j NEURAMINIDASE
(Influenza
A
virus) 		5 / 12 ARG A 118
ASP A 151
ARG A 156
TRP A 179
ARG A 223
 G39  A1470 (-3.1A)
G39  A1470 (-3.7A)
None
None
G39  A1470 (-4.0A)
 1.36A 3k37B-4b7jA:
53.1		 3k37B-4b7jA:
33.55
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3K37_B_BCZB468_0
(NEURAMINIDASE)		 4b7j NEURAMINIDASE
(Influenza
A
virus) 		11 / 12 ARG A 118
GLU A 119
LEU A 134
ASP A 151
ARG A 156
TRP A 179
ARG A 225
GLU A 228
GLU A 278
ARG A 293
ARG A 368
 G39  A1470 (-3.1A)
G39  A1470 (-3.5A)
None
G39  A1470 (-3.7A)
None
None
G39  A1470 (-4.4A)
None
G39  A1470 (-4.2A)
G39  A1470 (-2.9A)
G39  A1470 (-3.0A)
 0.42A 3k37B-4b7jA:
53.1		 3k37B-4b7jA:
33.55
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3K37_B_BCZB468_0
(NEURAMINIDASE)		 4hzz NEURAMINIDASE
(Influenza
A
virus) 		12 / 12 ARG A 118
GLU A 119
LEU A 134
ASP A 151
ARG A 156
TRP A 178
ARG A 224
GLU A 227
ALA A 246
GLU A 277
ARG A 292
ARG A 371
 G39  A 509 (-3.0A)
G39  A 509 (-3.3A)
None
G39  A 509 (-3.6A)
None
None
G39  A 509 (-4.7A)
None
G39  A 509 ( 4.1A)
G39  A 509 ( 4.0A)
G39  A 509 (-2.8A)
G39  A 509 (-2.9A)
 0.43A 3k37B-4hzzA:
52.3		 3k37B-4hzzA:
34.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K37_B_BCZB468_0
(NEURAMINIDASE)		 4yw5 NEURAMINIDASE C
(Streptococcus
pneumoniae) 		5 / 12 ARG A 290
ASP A 315
GLU A 584
ARG A 600
ARG A 662
 G39  A 801 (-2.6A)
G39  A 801 (-3.2A)
G39  A 801 ( 4.7A)
G39  A 801 (-2.9A)
G39  A 801 (-2.9A)
 0.79A 3k37B-4yw5A:
23.2		 3k37B-4yw5A:
20.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K37_B_BCZB468_0
(NEURAMINIDASE)		 6eks SIALIDASE
(Vibrio
cholerae) 		6 / 12 ARG A 250
ASP A 276
TRP A 337
GLU A 645
ARG A 661
ARG A 738
 G39  A 908 (-2.8A)
G39  A 908 (-3.3A)
None
G39  A 908 (-4.0A)
G39  A 908 (-2.8A)
G39  A 908 (-3.0A)
 0.69A 3k37B-6eksA:
13.7		 3k37B-6eksA:
19.84
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3K37_B_BCZB468_1
(NEURAMINIDASE)		 4b7j NEURAMINIDASE
(Influenza
A
virus) 		3 / 3 ARG A 152
GLU A 277
TYR A 402
 G39  A1470 (-3.9A)
G39  A1470 (-3.7A)
G39  A1470 (-4.5A)
 0.77A 3k37B-4b7jA:
53.1		 3k37B-4b7jA:
33.55
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3K37_B_BCZB468_1
(NEURAMINIDASE)		 4hzz NEURAMINIDASE
(Influenza
A
virus) 		3 / 3 ARG A 152
GLU A 276
TYR A 406
 G39  A 509 (-3.9A)
G39  A 509 ( 4.1A)
G39  A 509 (-4.6A)
 0.91A 3k37B-4hzzA:
52.3		 3k37B-4hzzA:
34.31
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3K39_A_BCZA1001_0
(NEURAMINIDASE)		 4b7j NEURAMINIDASE
(Influenza
A
virus) 		11 / 12 ARG A 118
GLU A 119
LEU A 134
ARG A 152
ARG A 156
ARG A 225
GLU A 228
GLU A 277
GLU A 278
ARG A 293
TYR A 402
 G39  A1470 (-3.1A)
G39  A1470 (-3.5A)
None
G39  A1470 (-3.9A)
None
G39  A1470 (-4.4A)
None
G39  A1470 (-3.7A)
G39  A1470 (-4.2A)
G39  A1470 (-2.9A)
G39  A1470 (-4.5A)
 0.60A 3k39A-4b7jA:
52.5		 3k39A-4b7jA:
33.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3K39_A_BCZA1001_0
(NEURAMINIDASE)		 4b7j NEURAMINIDASE
(Influenza
A
virus) 		5 / 12 ARG A 223
GLU A 228
GLU A 278
ARG A 293
TYR A 402
 G39  A1470 (-4.0A)
None
G39  A1470 (-4.2A)
G39  A1470 (-2.9A)
G39  A1470 (-4.5A)
 1.35A 3k39A-4b7jA:
52.5		 3k39A-4b7jA:
33.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3K39_A_BCZA1001_0
(NEURAMINIDASE)		 4hzz NEURAMINIDASE
(Influenza
A
virus) 		12 / 12 ARG A 118
GLU A 119
LEU A 134
ARG A 152
ARG A 156
ARG A 224
GLU A 227
ALA A 246
GLU A 276
GLU A 277
ARG A 292
TYR A 406
 G39  A 509 (-3.0A)
G39  A 509 (-3.3A)
None
G39  A 509 (-3.9A)
None
G39  A 509 (-4.7A)
None
G39  A 509 ( 4.1A)
G39  A 509 ( 4.1A)
G39  A 509 ( 4.0A)
G39  A 509 (-2.8A)
G39  A 509 (-4.6A)
 0.58A 3k39A-4hzzA:
51.8		 3k39A-4hzzA:
34.06
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3K39_B_BCZB1001_0
(NEURAMINIDASE)		 4b7j NEURAMINIDASE
(Influenza
A
virus) 		11 / 12 ARG A 118
GLU A 119
LEU A 134
ASP A 151
ARG A 152
ARG A 156
ARG A 225
GLU A 228
GLU A 278
ARG A 293
TYR A 402
 G39  A1470 (-3.1A)
G39  A1470 (-3.5A)
None
G39  A1470 (-3.7A)
G39  A1470 (-3.9A)
None
G39  A1470 (-4.4A)
None
G39  A1470 (-4.2A)
G39  A1470 (-2.9A)
G39  A1470 (-4.5A)
 0.59A 3k39B-4b7jA:
52.6		 3k39B-4b7jA:
33.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3K39_B_BCZB1001_0
(NEURAMINIDASE)		 4b7j NEURAMINIDASE
(Influenza
A
virus) 		5 / 12 ARG A 223
GLU A 228
GLU A 278
ARG A 293
TYR A 402
 G39  A1470 (-4.0A)
None
G39  A1470 (-4.2A)
G39  A1470 (-2.9A)
G39  A1470 (-4.5A)
 1.34A 3k39B-4b7jA:
52.6		 3k39B-4b7jA:
33.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3K39_B_BCZB1001_0
(NEURAMINIDASE)		 4hzz NEURAMINIDASE
(Influenza
A
virus) 		12 / 12 ARG A 118
GLU A 119
LEU A 134
ASP A 151
ARG A 152
ARG A 156
ARG A 224
GLU A 227
ALA A 246
GLU A 277
ARG A 292
TYR A 406
 G39  A 509 (-3.0A)
G39  A 509 (-3.3A)
None
G39  A 509 (-3.6A)
G39  A 509 (-3.9A)
None
G39  A 509 (-4.7A)
None
G39  A 509 ( 4.1A)
G39  A 509 ( 4.0A)
G39  A 509 (-2.8A)
G39  A 509 (-4.6A)
 0.56A 3k39B-4hzzA:
51.9		 3k39B-4hzzA:
34.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K39_B_BCZB1001_0
(NEURAMINIDASE)		 4yw5 NEURAMINIDASE C
(Streptococcus
pneumoniae) 		5 / 12 ARG A 290
ASP A 315
GLU A 584
ARG A 600
TYR A 695
 G39  A 801 (-2.6A)
G39  A 801 (-3.2A)
G39  A 801 ( 4.7A)
G39  A 801 (-2.9A)
G39  A 801 (-4.4A)
 0.73A 3k39B-4yw5A:
23.8		 3k39B-4yw5A:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K39_B_BCZB1001_0
(NEURAMINIDASE)		 6eks SIALIDASE
(Vibrio
cholerae) 		5 / 12 ARG A 250
ASP A 276
GLU A 645
ARG A 661
TYR A 766
 G39  A 908 (-2.8A)
G39  A 908 (-3.3A)
G39  A 908 (-4.0A)
G39  A 908 (-2.8A)
G39  A 908 (-4.6A)
 0.43A 3k39B-6eksA:
6.3		 3k39B-6eksA:
19.43
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3K39_C_BCZC1001_0
(NEURAMINIDASE)		 4b7j NEURAMINIDASE
(Influenza
A
virus) 		11 / 12 ARG A 118
GLU A 119
LEU A 134
ASP A 151
ARG A 152
ARG A 156
ARG A 225
GLU A 228
GLU A 277
GLU A 278
ARG A 293
 G39  A1470 (-3.1A)
G39  A1470 (-3.5A)
None
G39  A1470 (-3.7A)
G39  A1470 (-3.9A)
None
G39  A1470 (-4.4A)
None
G39  A1470 (-3.7A)
G39  A1470 (-4.2A)
G39  A1470 (-2.9A)
 0.60A 3k39C-4b7jA:
52.5		 3k39C-4b7jA:
33.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3K39_C_BCZC1001_0
(NEURAMINIDASE)		 4hzz NEURAMINIDASE
(Influenza
A
virus) 		12 / 12 ARG A 118
GLU A 119
LEU A 134
ASP A 151
ARG A 152
ARG A 156
ARG A 224
GLU A 227
ALA A 246
GLU A 276
GLU A 277
ARG A 292
 G39  A 509 (-3.0A)
G39  A 509 (-3.3A)
None
G39  A 509 (-3.6A)
G39  A 509 (-3.9A)
None
G39  A 509 (-4.7A)
None
G39  A 509 ( 4.1A)
G39  A 509 ( 4.1A)
G39  A 509 ( 4.0A)
G39  A 509 (-2.8A)
 0.59A 3k39C-4hzzA:
51.9		 3k39C-4hzzA:
34.06
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3K39_C_BCZC1001_0
(NEURAMINIDASE)		 4hzz NEURAMINIDASE
(Influenza
A
virus) 		5 / 12 ARG A 371
ARG A 224
ALA A 246
GLU A 276
GLU A 277
 G39  A 509 (-2.9A)
G39  A 509 (-4.7A)
G39  A 509 ( 4.1A)
G39  A 509 ( 4.1A)
G39  A 509 ( 4.0A)
 1.40A 3k39C-4hzzA:
51.9		 3k39C-4hzzA:
34.06
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3K39_C_BCZC1001_0
(NEURAMINIDASE)		 4hzz NEURAMINIDASE
(Influenza
A
virus) 		5 / 12 GLU A 119
LEU A 134
ASP A 151
ARG A 156
ARG A 371
 G39  A 509 (-3.3A)
None
G39  A 509 (-3.6A)
None
G39  A 509 (-2.9A)
 1.48A 3k39C-4hzzA:
51.9		 3k39C-4hzzA:
34.06
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3K39_D_BCZD1001_0
(NEURAMINIDASE)		 4b7j NEURAMINIDASE
(Influenza
A
virus) 		5 / 12 ARG A 223
GLU A 228
GLU A 278
ARG A 293
ARG A 368
 G39  A1470 (-4.0A)
None
G39  A1470 (-4.2A)
G39  A1470 (-2.9A)
G39  A1470 (-3.0A)
 1.30A 3k39D-4b7jA:
52.5		 3k39D-4b7jA:
33.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3K39_D_BCZD1001_0
(NEURAMINIDASE)		 4b7j NEURAMINIDASE
(Influenza
A
virus) 		11 / 12 GLU A 119
LEU A 134
ASP A 151
ARG A 152
ARG A 156
ARG A 225
GLU A 228
GLU A 277
GLU A 278
ARG A 293
ARG A 368
 G39  A1470 (-3.5A)
None
G39  A1470 (-3.7A)
G39  A1470 (-3.9A)
None
G39  A1470 (-4.4A)
None
G39  A1470 (-3.7A)
G39  A1470 (-4.2A)
G39  A1470 (-2.9A)
G39  A1470 (-3.0A)
 0.61A 3k39D-4b7jA:
52.5		 3k39D-4b7jA:
33.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3K39_D_BCZD1001_0
(NEURAMINIDASE)		 4hzz NEURAMINIDASE
(Influenza
A
virus) 		12 / 12 GLU A 119
LEU A 134
ASP A 151
ARG A 152
ARG A 156
ARG A 224
GLU A 227
ALA A 246
GLU A 276
GLU A 277
ARG A 292
ARG A 371
 G39  A 509 (-3.3A)
None
G39  A 509 (-3.6A)
G39  A 509 (-3.9A)
None
G39  A 509 (-4.7A)
None
G39  A 509 ( 4.1A)
G39  A 509 ( 4.1A)
G39  A 509 ( 4.0A)
G39  A 509 (-2.8A)
G39  A 509 (-2.9A)
 0.60A 3k39D-4hzzA:
51.9		 3k39D-4hzzA:
34.06
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3K39_E_BCZE1001_0
(NEURAMINIDASE)		 4b7j NEURAMINIDASE
(Influenza
A
virus) 		11 / 12 ARG A 118
GLU A 119
LEU A 134
ARG A 152
ARG A 156
ARG A 225
GLU A 228
GLU A 277
GLU A 278
ARG A 293
TYR A 402
 G39  A1470 (-3.1A)
G39  A1470 (-3.5A)
None
G39  A1470 (-3.9A)
None
G39  A1470 (-4.4A)
None
G39  A1470 (-3.7A)
G39  A1470 (-4.2A)
G39  A1470 (-2.9A)
G39  A1470 (-4.5A)
 0.61A 3k39E-4b7jA:
52.5		 3k39E-4b7jA:
33.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3K39_E_BCZE1001_0
(NEURAMINIDASE)		 4b7j NEURAMINIDASE
(Influenza
A
virus) 		5 / 12 ARG A 223
GLU A 228
GLU A 278
ARG A 293
TYR A 402
 G39  A1470 (-4.0A)
None
G39  A1470 (-4.2A)
G39  A1470 (-2.9A)
G39  A1470 (-4.5A)
 1.34A 3k39E-4b7jA:
52.5		 3k39E-4b7jA:
33.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3K39_E_BCZE1001_0
(NEURAMINIDASE)		 4hzz NEURAMINIDASE
(Influenza
A
virus) 		12 / 12 ARG A 118
GLU A 119
LEU A 134
ARG A 152
ARG A 156
ARG A 224
GLU A 227
ALA A 246
GLU A 276
GLU A 277
ARG A 292
TYR A 406
 G39  A 509 (-3.0A)
G39  A 509 (-3.3A)
None
G39  A 509 (-3.9A)
None
G39  A 509 (-4.7A)
None
G39  A 509 ( 4.1A)
G39  A 509 ( 4.1A)
G39  A 509 ( 4.0A)
G39  A 509 (-2.8A)
G39  A 509 (-4.6A)
 0.58A 3k39E-4hzzA:
51.9		 3k39E-4hzzA:
34.06
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3K39_F_BCZF1001_0
(NEURAMINIDASE)		 4b7j NEURAMINIDASE
(Influenza
A
virus) 		11 / 12 ARG A 118
GLU A 119
LEU A 134
ARG A 152
ARG A 156
ARG A 225
GLU A 228
GLU A 277
GLU A 278
ARG A 293
TYR A 402
 G39  A1470 (-3.1A)
G39  A1470 (-3.5A)
None
G39  A1470 (-3.9A)
None
G39  A1470 (-4.4A)
None
G39  A1470 (-3.7A)
G39  A1470 (-4.2A)
G39  A1470 (-2.9A)
G39  A1470 (-4.5A)
 0.60A 3k39F-4b7jA:
52.5		 3k39F-4b7jA:
33.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3K39_F_BCZF1001_0
(NEURAMINIDASE)		 4b7j NEURAMINIDASE
(Influenza
A
virus) 		5 / 12 ARG A 223
GLU A 228
GLU A 278
ARG A 293
TYR A 402
 G39  A1470 (-4.0A)
None
G39  A1470 (-4.2A)
G39  A1470 (-2.9A)
G39  A1470 (-4.5A)
 1.34A 3k39F-4b7jA:
52.5		 3k39F-4b7jA:
33.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3K39_F_BCZF1001_0
(NEURAMINIDASE)		 4hzz NEURAMINIDASE
(Influenza
A
virus) 		12 / 12 ARG A 118
GLU A 119
LEU A 134
ARG A 152
ARG A 156
ARG A 224
GLU A 227
ALA A 246
GLU A 276
GLU A 277
ARG A 292
TYR A 406
 G39  A 509 (-3.0A)
G39  A 509 (-3.3A)
None
G39  A 509 (-3.9A)
None
G39  A 509 (-4.7A)
None
G39  A 509 ( 4.1A)
G39  A 509 ( 4.1A)
G39  A 509 ( 4.0A)
G39  A 509 (-2.8A)
G39  A 509 (-4.6A)
 0.57A 3k39F-4hzzA:
51.9		 3k39F-4hzzA:
34.06
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3K39_G_BCZG1001_0
(NEURAMINIDASE)		 4b7j NEURAMINIDASE
(Influenza
A
virus) 		11 / 12 ARG A 118
GLU A 119
LEU A 134
ARG A 152
ARG A 156
ARG A 225
GLU A 228
GLU A 277
GLU A 278
ARG A 293
TYR A 402
 G39  A1470 (-3.1A)
G39  A1470 (-3.5A)
None
G39  A1470 (-3.9A)
None
G39  A1470 (-4.4A)
None
G39  A1470 (-3.7A)
G39  A1470 (-4.2A)
G39  A1470 (-2.9A)
G39  A1470 (-4.5A)
 0.60A 3k39G-4b7jA:
52.5		 3k39G-4b7jA:
33.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3K39_G_BCZG1001_0
(NEURAMINIDASE)		 4b7j NEURAMINIDASE
(Influenza
A
virus) 		5 / 12 ARG A 223
GLU A 228
GLU A 278
ARG A 293
TYR A 402
 G39  A1470 (-4.0A)
None
G39  A1470 (-4.2A)
G39  A1470 (-2.9A)
G39  A1470 (-4.5A)
 1.32A 3k39G-4b7jA:
52.5		 3k39G-4b7jA:
33.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3K39_G_BCZG1001_0
(NEURAMINIDASE)		 4hzz NEURAMINIDASE
(Influenza
A
virus) 		12 / 12 ARG A 118
GLU A 119
LEU A 134
ARG A 152
ARG A 156
ARG A 224
GLU A 227
ALA A 246
GLU A 276
GLU A 277
ARG A 292
TYR A 406
 G39  A 509 (-3.0A)
G39  A 509 (-3.3A)
None
G39  A 509 (-3.9A)
None
G39  A 509 (-4.7A)
None
G39  A 509 ( 4.1A)
G39  A 509 ( 4.1A)
G39  A 509 ( 4.0A)
G39  A 509 (-2.8A)
G39  A 509 (-4.6A)
 0.58A 3k39G-4hzzA:
51.9		 3k39G-4hzzA:
34.06
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3K39_H_BCZH1001_0
(NEURAMINIDASE)		 4b7j NEURAMINIDASE
(Influenza
A
virus) 		11 / 12 ARG A 118
GLU A 119
LEU A 134
ARG A 152
ARG A 156
ARG A 225
GLU A 228
GLU A 277
GLU A 278
ARG A 293
TYR A 402
 G39  A1470 (-3.1A)
G39  A1470 (-3.5A)
None
G39  A1470 (-3.9A)
None
G39  A1470 (-4.4A)
None
G39  A1470 (-3.7A)
G39  A1470 (-4.2A)
G39  A1470 (-2.9A)
G39  A1470 (-4.5A)
 0.60A 3k39H-4b7jA:
52.5		 3k39H-4b7jA:
33.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3K39_H_BCZH1001_0
(NEURAMINIDASE)		 4b7j NEURAMINIDASE
(Influenza
A
virus) 		5 / 12 ARG A 223
GLU A 228
GLU A 278
ARG A 293
TYR A 402
 G39  A1470 (-4.0A)
None
G39  A1470 (-4.2A)
G39  A1470 (-2.9A)
G39  A1470 (-4.5A)
 1.33A 3k39H-4b7jA:
52.5		 3k39H-4b7jA:
33.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3K39_H_BCZH1001_0
(NEURAMINIDASE)		 4hzz NEURAMINIDASE
(Influenza
A
virus) 		12 / 12 ARG A 118
GLU A 119
LEU A 134
ARG A 152
ARG A 156
ARG A 224
GLU A 227
ALA A 246
GLU A 276
GLU A 277
ARG A 292
TYR A 406
 G39  A 509 (-3.0A)
G39  A 509 (-3.3A)
None
G39  A 509 (-3.9A)
None
G39  A 509 (-4.7A)
None
G39  A 509 ( 4.1A)
G39  A 509 ( 4.1A)
G39  A 509 ( 4.0A)
G39  A 509 (-2.8A)
G39  A 509 (-4.6A)
 0.57A 3k39H-4hzzA:
51.9		 3k39H-4hzzA:
34.06
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3K39_I_BCZI1001_0
(NEURAMINIDASE)		 4b7j NEURAMINIDASE
(Influenza
A
virus) 		11 / 12 ARG A 118
GLU A 119
LEU A 134
ASP A 151
ARG A 152
ARG A 156
ARG A 225
GLU A 228
GLU A 277
GLU A 278
ARG A 293
 G39  A1470 (-3.1A)
G39  A1470 (-3.5A)
None
G39  A1470 (-3.7A)
G39  A1470 (-3.9A)
None
G39  A1470 (-4.4A)
None
G39  A1470 (-3.7A)
G39  A1470 (-4.2A)
G39  A1470 (-2.9A)
 0.61A 3k39I-4b7jA:
52.5		 3k39I-4b7jA:
33.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3K39_I_BCZI1001_0
(NEURAMINIDASE)		 4hzz NEURAMINIDASE
(Influenza
A
virus) 		12 / 12 ARG A 118
GLU A 119
LEU A 134
ASP A 151
ARG A 152
ARG A 156
ARG A 224
GLU A 227
ALA A 246
GLU A 276
GLU A 277
ARG A 292
 G39  A 509 (-3.0A)
G39  A 509 (-3.3A)
None
G39  A 509 (-3.6A)
G39  A 509 (-3.9A)
None
G39  A 509 (-4.7A)
None
G39  A 509 ( 4.1A)
G39  A 509 ( 4.1A)
G39  A 509 ( 4.0A)
G39  A 509 (-2.8A)
 0.59A 3k39I-4hzzA:
51.8		 3k39I-4hzzA:
34.06
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3K39_I_BCZI1001_0
(NEURAMINIDASE)		 4hzz NEURAMINIDASE
(Influenza
A
virus) 		5 / 12 ARG A 371
ARG A 224
ALA A 246
GLU A 276
GLU A 277
 G39  A 509 (-2.9A)
G39  A 509 (-4.7A)
G39  A 509 ( 4.1A)
G39  A 509 ( 4.1A)
G39  A 509 ( 4.0A)
 1.39A 3k39I-4hzzA:
51.8		 3k39I-4hzzA:
34.06
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3K39_I_BCZI1001_0
(NEURAMINIDASE)		 4hzz NEURAMINIDASE
(Influenza
A
virus) 		5 / 12 GLU A 119
LEU A 134
ASP A 151
ARG A 156
ARG A 371
 G39  A 509 (-3.3A)
None
G39  A 509 (-3.6A)
None
G39  A 509 (-2.9A)
 1.47A 3k39I-4hzzA:
51.8		 3k39I-4hzzA:
34.06
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3K39_J_BCZJ1001_0
(NEURAMINIDASE)		 4b7j NEURAMINIDASE
(Influenza
A
virus) 		11 / 12 ARG A 118
GLU A 119
LEU A 134
ASP A 151
ARG A 152
ARG A 156
ARG A 225
GLU A 228
GLU A 277
GLU A 278
ARG A 293
 G39  A1470 (-3.1A)
G39  A1470 (-3.5A)
None
G39  A1470 (-3.7A)
G39  A1470 (-3.9A)
None
G39  A1470 (-4.4A)
None
G39  A1470 (-3.7A)
G39  A1470 (-4.2A)
G39  A1470 (-2.9A)
 0.60A 3k39J-4b7jA:
52.5		 3k39J-4b7jA:
33.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3K39_J_BCZJ1001_0
(NEURAMINIDASE)		 4hzz NEURAMINIDASE
(Influenza
A
virus) 		12 / 12 ARG A 118
GLU A 119
LEU A 134
ASP A 151
ARG A 152
ARG A 156
ARG A 224
GLU A 227
ALA A 246
GLU A 276
GLU A 277
ARG A 292
 G39  A 509 (-3.0A)
G39  A 509 (-3.3A)
None
G39  A 509 (-3.6A)
G39  A 509 (-3.9A)
None
G39  A 509 (-4.7A)
None
G39  A 509 ( 4.1A)
G39  A 509 ( 4.1A)
G39  A 509 ( 4.0A)
G39  A 509 (-2.8A)
 0.58A 3k39J-4hzzA:
51.9		 3k39J-4hzzA:
34.06
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3K39_J_BCZJ1001_0
(NEURAMINIDASE)		 4hzz NEURAMINIDASE
(Influenza
A
virus) 		5 / 12 ARG A 371
ARG A 224
ALA A 246
GLU A 276
GLU A 277
 G39  A 509 (-2.9A)
G39  A 509 (-4.7A)
G39  A 509 ( 4.1A)
G39  A 509 ( 4.1A)
G39  A 509 ( 4.0A)
 1.37A 3k39J-4hzzA:
51.9		 3k39J-4hzzA:
34.06
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3K39_J_BCZJ1001_0
(NEURAMINIDASE)		 4hzz NEURAMINIDASE
(Influenza
A
virus) 		5 / 12 GLU A 119
LEU A 134
ASP A 151
ARG A 156
ARG A 371
 G39  A 509 (-3.3A)
None
G39  A 509 (-3.6A)
None
G39  A 509 (-2.9A)
 1.48A 3k39J-4hzzA:
51.9		 3k39J-4hzzA:
34.06
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3K39_K_BCZK1001_0
(NEURAMINIDASE)		 4b7j NEURAMINIDASE
(Influenza
A
virus) 		11 / 12 ARG A 118
GLU A 119
LEU A 134
ASP A 151
ARG A 152
ARG A 156
ARG A 225
GLU A 228
GLU A 277
GLU A 278
ARG A 293
 G39  A1470 (-3.1A)
G39  A1470 (-3.5A)
None
G39  A1470 (-3.7A)
G39  A1470 (-3.9A)
None
G39  A1470 (-4.4A)
None
G39  A1470 (-3.7A)
G39  A1470 (-4.2A)
G39  A1470 (-2.9A)
 0.60A 3k39K-4b7jA:
52.5		 3k39K-4b7jA:
33.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3K39_K_BCZK1001_0
(NEURAMINIDASE)		 4hzz NEURAMINIDASE
(Influenza
A
virus) 		12 / 12 ARG A 118
GLU A 119
LEU A 134
ASP A 151
ARG A 152
ARG A 156
ARG A 224
GLU A 227
ALA A 246
GLU A 276
GLU A 277
ARG A 292
 G39  A 509 (-3.0A)
G39  A 509 (-3.3A)
None
G39  A 509 (-3.6A)
G39  A 509 (-3.9A)
None
G39  A 509 (-4.7A)
None
G39  A 509 ( 4.1A)
G39  A 509 ( 4.1A)
G39  A 509 ( 4.0A)
G39  A 509 (-2.8A)
 0.58A 3k39K-4hzzA:
51.9		 3k39K-4hzzA:
34.06
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3K39_K_BCZK1001_0
(NEURAMINIDASE)		 4hzz NEURAMINIDASE
(Influenza
A
virus) 		5 / 12 ARG A 371
ARG A 224
ALA A 246
GLU A 276
GLU A 277
 G39  A 509 (-2.9A)
G39  A 509 (-4.7A)
G39  A 509 ( 4.1A)
G39  A 509 ( 4.1A)
G39  A 509 ( 4.0A)
 1.39A 3k39K-4hzzA:
51.9		 3k39K-4hzzA:
34.06
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3K39_K_BCZK1001_0
(NEURAMINIDASE)		 4hzz NEURAMINIDASE
(Influenza
A
virus) 		5 / 12 GLU A 119
LEU A 134
ASP A 151
ARG A 156
ARG A 371
 G39  A 509 (-3.3A)
None
G39  A 509 (-3.6A)
None
G39  A 509 (-2.9A)
 1.48A 3k39K-4hzzA:
51.9		 3k39K-4hzzA:
34.06
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3K39_L_BCZL1001_0
(NEURAMINIDASE)		 4b7j NEURAMINIDASE
(Influenza
A
virus) 		11 / 12 ARG A 118
GLU A 119
LEU A 134
ASP A 151
ARG A 152
ARG A 156
ARG A 225
GLU A 228
GLU A 277
GLU A 278
ARG A 293
 G39  A1470 (-3.1A)
G39  A1470 (-3.5A)
None
G39  A1470 (-3.7A)
G39  A1470 (-3.9A)
None
G39  A1470 (-4.4A)
None
G39  A1470 (-3.7A)
G39  A1470 (-4.2A)
G39  A1470 (-2.9A)
 0.61A 3k39L-4b7jA:
52.6		 3k39L-4b7jA:
33.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3K39_L_BCZL1001_0
(NEURAMINIDASE)		 4hzz NEURAMINIDASE
(Influenza
A
virus) 		12 / 12 ARG A 118
GLU A 119
LEU A 134
ASP A 151
ARG A 152
ARG A 156
ARG A 224
GLU A 227
ALA A 246
GLU A 276
GLU A 277
ARG A 292
 G39  A 509 (-3.0A)
G39  A 509 (-3.3A)
None
G39  A 509 (-3.6A)
G39  A 509 (-3.9A)
None
G39  A 509 (-4.7A)
None
G39  A 509 ( 4.1A)
G39  A 509 ( 4.1A)
G39  A 509 ( 4.0A)
G39  A 509 (-2.8A)
 0.59A 3k39L-4hzzA:
51.9		 3k39L-4hzzA:
34.06
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3K39_L_BCZL1001_0
(NEURAMINIDASE)		 4hzz NEURAMINIDASE
(Influenza
A
virus) 		5 / 12 ARG A 371
ARG A 224
ALA A 246
GLU A 276
GLU A 277
 G39  A 509 (-2.9A)
G39  A 509 (-4.7A)
G39  A 509 ( 4.1A)
G39  A 509 ( 4.1A)
G39  A 509 ( 4.0A)
 1.39A 3k39L-4hzzA:
51.9		 3k39L-4hzzA:
34.06
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3K39_L_BCZL1001_0
(NEURAMINIDASE)		 4hzz NEURAMINIDASE
(Influenza
A
virus) 		5 / 12 GLU A 119
LEU A 134
ASP A 151
ARG A 156
ARG A 371
 G39  A 509 (-3.3A)
None
G39  A 509 (-3.6A)
None
G39  A 509 (-2.9A)
 1.49A 3k39L-4hzzA:
51.9		 3k39L-4hzzA:
34.06
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3K39_M_BCZM1001_0
(NEURAMINIDASE)		 4b7j NEURAMINIDASE
(Influenza
A
virus) 		11 / 12 ARG A 118
GLU A 119
LEU A 134
ARG A 152
ARG A 156
ARG A 225
GLU A 228
GLU A 277
GLU A 278
ARG A 293
TYR A 402
 G39  A1470 (-3.1A)
G39  A1470 (-3.5A)
None
G39  A1470 (-3.9A)
None
G39  A1470 (-4.4A)
None
G39  A1470 (-3.7A)
G39  A1470 (-4.2A)
G39  A1470 (-2.9A)
G39  A1470 (-4.5A)
 0.61A 3k39M-4b7jA:
52.6		 3k39M-4b7jA:
33.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3K39_M_BCZM1001_0
(NEURAMINIDASE)		 4b7j NEURAMINIDASE
(Influenza
A
virus) 		5 / 12 ARG A 223
GLU A 228
GLU A 278
ARG A 293
TYR A 402
 G39  A1470 (-4.0A)
None
G39  A1470 (-4.2A)
G39  A1470 (-2.9A)
G39  A1470 (-4.5A)
 1.35A 3k39M-4b7jA:
52.6		 3k39M-4b7jA:
33.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3K39_M_BCZM1001_0
(NEURAMINIDASE)		 4hzz NEURAMINIDASE
(Influenza
A
virus) 		12 / 12 ARG A 118
GLU A 119
LEU A 134
ARG A 152
ARG A 156
ARG A 224
GLU A 227
ALA A 246
GLU A 276
GLU A 277
ARG A 292
TYR A 406
 G39  A 509 (-3.0A)
G39  A 509 (-3.3A)
None
G39  A 509 (-3.9A)
None
G39  A 509 (-4.7A)
None
G39  A 509 ( 4.1A)
G39  A 509 ( 4.1A)
G39  A 509 ( 4.0A)
G39  A 509 (-2.8A)
G39  A 509 (-4.6A)
 0.57A 3k39M-4hzzA:
51.9		 3k39M-4hzzA:
34.06
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3K39_N_BCZN1001_0
(NEURAMINIDASE)		 4b7j NEURAMINIDASE
(Influenza
A
virus) 		6 / 12 ARG A 223
GLU A 228
GLU A 278
ARG A 293
ARG A 368
TYR A 402
 G39  A1470 (-4.0A)
None
G39  A1470 (-4.2A)
G39  A1470 (-2.9A)
G39  A1470 (-3.0A)
G39  A1470 (-4.5A)
 1.24A 3k39N-4b7jA:
52.6		 3k39N-4b7jA:
33.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3K39_N_BCZN1001_0
(NEURAMINIDASE)		 4b7j NEURAMINIDASE
(Influenza
A
virus) 		11 / 12 GLU A 119
LEU A 134
ARG A 152
ARG A 156
ARG A 225
GLU A 228
GLU A 277
GLU A 278
ARG A 293
ARG A 368
TYR A 402
 G39  A1470 (-3.5A)
None
G39  A1470 (-3.9A)
None
G39  A1470 (-4.4A)
None
G39  A1470 (-3.7A)
G39  A1470 (-4.2A)
G39  A1470 (-2.9A)
G39  A1470 (-3.0A)
G39  A1470 (-4.5A)
 0.60A 3k39N-4b7jA:
52.6		 3k39N-4b7jA:
33.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3K39_N_BCZN1001_0
(NEURAMINIDASE)		 4hzz NEURAMINIDASE
(Influenza
A
virus) 		12 / 12 GLU A 119
LEU A 134
ARG A 152
ARG A 156
ARG A 224
GLU A 227
ALA A 246
GLU A 276
GLU A 277
ARG A 292
ARG A 371
TYR A 406
 G39  A 509 (-3.3A)
None
G39  A 509 (-3.9A)
None
G39  A 509 (-4.7A)
None
G39  A 509 ( 4.1A)
G39  A 509 ( 4.1A)
G39  A 509 ( 4.0A)
G39  A 509 (-2.8A)
G39  A 509 (-2.9A)
G39  A 509 (-4.6A)
 0.58A 3k39N-4hzzA:
51.9		 3k39N-4hzzA:
34.06
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3K39_O_BCZO1001_0
(NEURAMINIDASE)		 4b7j NEURAMINIDASE
(Influenza
A
virus) 		11 / 12 ARG A 118
GLU A 119
LEU A 134
ARG A 152
ARG A 156
ARG A 225
GLU A 228
GLU A 277
GLU A 278
ARG A 368
TYR A 402
 G39  A1470 (-3.1A)
G39  A1470 (-3.5A)
None
G39  A1470 (-3.9A)
None
G39  A1470 (-4.4A)
None
G39  A1470 (-3.7A)
G39  A1470 (-4.2A)
G39  A1470 (-3.0A)
G39  A1470 (-4.5A)
 0.61A 3k39O-4b7jA:
52.5		 3k39O-4b7jA:
33.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3K39_O_BCZO1001_0
(NEURAMINIDASE)		 4b7j NEURAMINIDASE
(Influenza
A
virus) 		5 / 12 ARG A 223
GLU A 228
GLU A 278
ARG A 368
TYR A 402
 G39  A1470 (-4.0A)
None
G39  A1470 (-4.2A)
G39  A1470 (-3.0A)
G39  A1470 (-4.5A)
 1.17A 3k39O-4b7jA:
52.5		 3k39O-4b7jA:
33.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3K39_O_BCZO1001_0
(NEURAMINIDASE)		 4hzz NEURAMINIDASE
(Influenza
A
virus) 		12 / 12 ARG A 118
GLU A 119
LEU A 134
ARG A 152
ARG A 156
ARG A 224
GLU A 227
ALA A 246
GLU A 276
GLU A 277
ARG A 371
TYR A 406
 G39  A 509 (-3.0A)
G39  A 509 (-3.3A)
None
G39  A 509 (-3.9A)
None
G39  A 509 (-4.7A)
None
G39  A 509 ( 4.1A)
G39  A 509 ( 4.1A)
G39  A 509 ( 4.0A)
G39  A 509 (-2.9A)
G39  A 509 (-4.6A)
 0.56A 3k39O-4hzzA:
51.9		 3k39O-4hzzA:
34.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K39_O_BCZO1001_0
(NEURAMINIDASE)		 6eks SIALIDASE
(Vibrio
cholerae) 		5 / 12 ARG A 738
GLU A 782
GLU A 269
ARG A 661
TYR A 766
 G39  A 908 (-3.0A)
None
G39  A 908 ( 4.7A)
G39  A 908 (-2.8A)
G39  A 908 (-4.6A)
 1.40A 3k39O-6eksA:
13.8		 3k39O-6eksA:
19.43
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3K39_P_BCZP1001_0
(NEURAMINIDASE)		 4b7j NEURAMINIDASE
(Influenza
A
virus) 		5 / 12 ARG A 152
GLU A 119
ARG A 293
ARG A 368
TYR A 402
 G39  A1470 (-3.9A)
G39  A1470 (-3.5A)
G39  A1470 (-2.9A)
G39  A1470 (-3.0A)
G39  A1470 (-4.5A)
 1.49A 3k39P-4b7jA:
52.6		 3k39P-4b7jA:
33.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3K39_P_BCZP1001_0
(NEURAMINIDASE)		 4b7j NEURAMINIDASE
(Influenza
A
virus) 		6 / 12 ARG A 223
GLU A 228
GLU A 278
ARG A 293
ARG A 368
TYR A 402
 G39  A1470 (-4.0A)
None
G39  A1470 (-4.2A)
G39  A1470 (-2.9A)
G39  A1470 (-3.0A)
G39  A1470 (-4.5A)
 1.26A 3k39P-4b7jA:
52.6		 3k39P-4b7jA:
33.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3K39_P_BCZP1001_0
(NEURAMINIDASE)		 4b7j NEURAMINIDASE
(Influenza
A
virus) 		11 / 12 GLU A 119
LEU A 134
ARG A 152
ARG A 156
ARG A 225
GLU A 228
GLU A 277
GLU A 278
ARG A 293
ARG A 368
TYR A 402
 G39  A1470 (-3.5A)
None
G39  A1470 (-3.9A)
None
G39  A1470 (-4.4A)
None
G39  A1470 (-3.7A)
G39  A1470 (-4.2A)
G39  A1470 (-2.9A)
G39  A1470 (-3.0A)
G39  A1470 (-4.5A)
 0.60A 3k39P-4b7jA:
52.6		 3k39P-4b7jA:
33.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3K39_P_BCZP1001_0
(NEURAMINIDASE)		 4hzz NEURAMINIDASE
(Influenza
A
virus) 		12 / 12 GLU A 119
LEU A 134
ARG A 152
ARG A 156
ARG A 224
GLU A 227
ALA A 246
GLU A 276
GLU A 277
ARG A 292
ARG A 371
TYR A 406
 G39  A 509 (-3.3A)
None
G39  A 509 (-3.9A)
None
G39  A 509 (-4.7A)
None
G39  A 509 ( 4.1A)
G39  A 509 ( 4.1A)
G39  A 509 ( 4.0A)
G39  A 509 (-2.8A)
G39  A 509 (-2.9A)
G39  A 509 (-4.6A)
 0.59A 3k39P-4hzzA:
51.9		 3k39P-4hzzA:
34.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N2O_C_AG2C1002_1
(BIOSYNTHETIC
ARGININE
DECARBOXYLASE)		 4b7j NEURAMINIDASE
(Influenza
A
virus) 		4 / 8 HIS A 275
SER A 247
ASP A 199
ASP A 244
 None
G39  A1470 ( 4.3A)
None
None
 1.19A 3n2oC-4b7jA:
undetectable
3n2oD-4b7jA:
undetectable		 3n2oC-4b7jA:
19.85
3n2oD-4b7jA:
19.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P2K_A_SAMA6735_1
(16S RRNA METHYLASE)		 6eks SIALIDASE
(Vibrio
cholerae) 		3 / 3 ASP A 318
GLU A 782
SER A 569
 G39  A 908 ( 4.2A)
None
None
 0.67A 3p2kA-6eksA:
undetectable		 3p2kA-6eksA:
14.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P2K_C_SAMC6735_1
(16S RRNA METHYLASE)		 6eks SIALIDASE
(Vibrio
cholerae) 		4 / 5 ASN A 354
ASP A 318
GLU A 782
SER A 569
 None
G39  A 908 ( 4.2A)
None
None
 1.30A 3p2kC-6eksA:
undetectable		 3p2kC-6eksA:
14.81
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3SAN_A_ZMRA901_1
(NEURAMINIDASE)		 4b7j NEURAMINIDASE
(Influenza
A
virus) 		10 / 12 ARG A 118
GLU A 119
ARG A 225
GLU A 228
GLU A 277
GLU A 278
ARG A 293
ASN A 295
ARG A 368
TYR A 402
 G39  A1470 (-3.1A)
G39  A1470 (-3.5A)
G39  A1470 (-4.4A)
None
G39  A1470 (-3.7A)
G39  A1470 (-4.2A)
G39  A1470 (-2.9A)
G39  A1470 ( 3.7A)
G39  A1470 (-3.0A)
G39  A1470 (-4.5A)
 0.56A 3sanA-4b7jA:
69.8		 3sanA-4b7jA:
48.41
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3SAN_A_ZMRA901_1
(NEURAMINIDASE)		 4hzz NEURAMINIDASE
(Influenza
A
virus) 		8 / 12 ARG A 118
GLU A 119
ARG A 224
GLU A 227
ALA A 246
GLU A 276
GLU A 277
TYR A 406
 G39  A 509 (-3.0A)
G39  A 509 (-3.3A)
G39  A 509 (-4.7A)
None
G39  A 509 ( 4.1A)
G39  A 509 ( 4.1A)
G39  A 509 ( 4.0A)
G39  A 509 (-4.6A)
 0.58A 3sanA-4hzzA:
64.3		 3sanA-4hzzA:
45.52
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3SAN_A_ZMRA901_1
(NEURAMINIDASE)		 4hzz NEURAMINIDASE
(Influenza
A
virus) 		9 / 12 ARG A 118
GLU A 119
ARG A 224
GLU A 227
ALA A 246
GLU A 277
ARG A 292
ARG A 371
TYR A 406
 G39  A 509 (-3.0A)
G39  A 509 (-3.3A)
G39  A 509 (-4.7A)
None
G39  A 509 ( 4.1A)
G39  A 509 ( 4.0A)
G39  A 509 (-2.8A)
G39  A 509 (-2.9A)
G39  A 509 (-4.6A)
 0.35A 3sanA-4hzzA:
64.3		 3sanA-4hzzA:
45.52
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3SAN_A_ZMRA901_1
(NEURAMINIDASE)		 4hzz NEURAMINIDASE
(Influenza
A
virus) 		8 / 12 GLU A 119
ARG A 224
GLU A 227
ALA A 246
GLU A 276
GLU A 277
ASN A 294
TYR A 406
 G39  A 509 (-3.3A)
G39  A 509 (-4.7A)
None
G39  A 509 ( 4.1A)
G39  A 509 ( 4.1A)
G39  A 509 ( 4.0A)
G39  A 509 ( 4.4A)
G39  A 509 (-4.6A)
 0.91A 3sanA-4hzzA:
64.3		 3sanA-4hzzA:
45.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SAN_A_ZMRA901_1
(NEURAMINIDASE)		 4yw5 NEURAMINIDASE C
(Streptococcus
pneumoniae) 		5 / 12 ARG A 290
GLU A 584
ARG A 600
ARG A 662
TYR A 695
 G39  A 801 (-2.6A)
G39  A 801 ( 4.7A)
G39  A 801 (-2.9A)
G39  A 801 (-2.9A)
G39  A 801 (-4.4A)
 0.44A 3sanA-4yw5A:
3.3		 3sanA-4yw5A:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SAN_A_ZMRA901_1
(NEURAMINIDASE)		 6eks SIALIDASE
(Vibrio
cholerae) 		5 / 12 ARG A 250
GLU A 645
ARG A 661
ARG A 738
TYR A 766
 G39  A 908 (-2.8A)
G39  A 908 (-4.0A)
G39  A 908 (-2.8A)
G39  A 908 (-3.0A)
G39  A 908 (-4.6A)
 0.34A 3sanA-6eksA:
21.5		 3sanA-6eksA:
20.26
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3SAN_A_ZMRA901_2
(NEURAMINIDASE)		 4b7j NEURAMINIDASE
(Influenza
A
virus) 		4 / 5 ASP A 151
ARG A 152
ARG A 156
TRP A 179
 G39  A1470 (-3.7A)
G39  A1470 (-3.9A)
None
None
 0.13A 3sanA-4b7jA:
69.8		 3sanA-4b7jA:
48.41
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3SAN_A_ZMRA901_2
(NEURAMINIDASE)		 4hzz NEURAMINIDASE
(Influenza
A
virus) 		5 / 5 ASP A 151
ARG A 152
ARG A 156
TRP A 178
ILE A 222
 G39  A 509 (-3.6A)
G39  A 509 (-3.9A)
None
None
G39  A 509 ( 4.1A)
 0.16A 3sanA-4hzzA:
64.3		 3sanA-4hzzA:
45.52
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3SAN_B_ZMRB901_1
(NEURAMINIDASE)		 4b7j NEURAMINIDASE
(Influenza
A
virus) 		10 / 12 ARG A 118
GLU A 119
ARG A 225
GLU A 228
GLU A 277
GLU A 278
ARG A 293
ASN A 295
ARG A 368
TYR A 402
 G39  A1470 (-3.1A)
G39  A1470 (-3.5A)
G39  A1470 (-4.4A)
None
G39  A1470 (-3.7A)
G39  A1470 (-4.2A)
G39  A1470 (-2.9A)
G39  A1470 ( 3.7A)
G39  A1470 (-3.0A)
G39  A1470 (-4.5A)
 0.55A 3sanB-4b7jA:
69.7		 3sanB-4b7jA:
48.41
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3SAN_B_ZMRB901_1
(NEURAMINIDASE)		 4hzz NEURAMINIDASE
(Influenza
A
virus) 		9 / 12 ARG A 118
GLU A 119
ARG A 224
GLU A 227
ALA A 246
GLU A 276
GLU A 277
ARG A 371
TYR A 406
 G39  A 509 (-3.0A)
G39  A 509 (-3.3A)
G39  A 509 (-4.7A)
None
G39  A 509 ( 4.1A)
G39  A 509 ( 4.1A)
G39  A 509 ( 4.0A)
G39  A 509 (-2.9A)
G39  A 509 (-4.6A)
 0.57A 3sanB-4hzzA:
64.2		 3sanB-4hzzA:
45.52
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3SAN_B_ZMRB901_1
(NEURAMINIDASE)		 4hzz NEURAMINIDASE
(Influenza
A
virus) 		9 / 12 ARG A 118
GLU A 119
ARG A 224
GLU A 227
ALA A 246
GLU A 277
ARG A 292
ARG A 371
TYR A 406
 G39  A 509 (-3.0A)
G39  A 509 (-3.3A)
G39  A 509 (-4.7A)
None
G39  A 509 ( 4.1A)
G39  A 509 ( 4.0A)
G39  A 509 (-2.8A)
G39  A 509 (-2.9A)
G39  A 509 (-4.6A)
 0.34A 3sanB-4hzzA:
64.2		 3sanB-4hzzA:
45.52
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3SAN_B_ZMRB901_1
(NEURAMINIDASE)		 4hzz NEURAMINIDASE
(Influenza
A
virus) 		8 / 12 GLU A 119
ARG A 224
GLU A 227
ALA A 246
GLU A 276
GLU A 277
ASN A 294
TYR A 406
 G39  A 509 (-3.3A)
G39  A 509 (-4.7A)
None
G39  A 509 ( 4.1A)
G39  A 509 ( 4.1A)
G39  A 509 ( 4.0A)
G39  A 509 ( 4.4A)
G39  A 509 (-4.6A)
 0.90A 3sanB-4hzzA:
64.2		 3sanB-4hzzA:
45.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SAN_B_ZMRB901_1
(NEURAMINIDASE)		 4yw5 NEURAMINIDASE C
(Streptococcus
pneumoniae) 		5 / 12 ARG A 290
GLU A 584
ARG A 600
ARG A 662
TYR A 695
 G39  A 801 (-2.6A)
G39  A 801 ( 4.7A)
G39  A 801 (-2.9A)
G39  A 801 (-2.9A)
G39  A 801 (-4.4A)
 0.44A 3sanB-4yw5A:
10.3		 3sanB-4yw5A:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SAN_B_ZMRB901_1
(NEURAMINIDASE)		 6eks SIALIDASE
(Vibrio
cholerae) 		5 / 12 ARG A 250
GLU A 645
ARG A 661
ARG A 738
TYR A 766
 G39  A 908 (-2.8A)
G39  A 908 (-4.0A)
G39  A 908 (-2.8A)
G39  A 908 (-3.0A)
G39  A 908 (-4.6A)
 0.34A 3sanB-6eksA:
21.6		 3sanB-6eksA:
20.26
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3SAN_B_ZMRB901_2
(NEURAMINIDASE)		 4b7j NEURAMINIDASE
(Influenza
A
virus) 		4 / 5 ASP A 151
ARG A 152
ARG A 156
TRP A 179
 G39  A1470 (-3.7A)
G39  A1470 (-3.9A)
None
None
 0.13A 3sanB-4b7jA:
69.7		 3sanB-4b7jA:
48.41
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3SAN_B_ZMRB901_2
(NEURAMINIDASE)		 4hzz NEURAMINIDASE
(Influenza
A
virus) 		5 / 5 ASP A 151
ARG A 152
ARG A 156
TRP A 178
ILE A 222
 G39  A 509 (-3.6A)
G39  A 509 (-3.9A)
None
None
G39  A 509 ( 4.1A)
 0.17A 3sanB-4hzzA:
64.2		 3sanB-4hzzA:
45.52
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3TI5_A_ZMRA1002_1
(NEURAMINIDASE)		 4b7j NEURAMINIDASE
(Influenza
A
virus) 		12 / 12 ARG A 118
GLU A 119
ASP A 151
ARG A 225
GLU A 228
SER A 247
GLU A 277
GLU A 278
ARG A 293
ASN A 295
ARG A 368
TYR A 402
 G39  A1470 (-3.1A)
G39  A1470 (-3.5A)
G39  A1470 (-3.7A)
G39  A1470 (-4.4A)
None
G39  A1470 ( 4.3A)
G39  A1470 (-3.7A)
G39  A1470 (-4.2A)
G39  A1470 (-2.9A)
G39  A1470 ( 3.7A)
G39  A1470 (-3.0A)
G39  A1470 (-4.5A)
 0.54A 3ti5A-4b7jA:
75.7		 3ti5A-4b7jA:
98.97
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3TI5_A_ZMRA1002_1
(NEURAMINIDASE)		 4b7j NEURAMINIDASE
(Influenza
A
virus) 		5 / 12 GLU A 228
SER A 247
ARG A 293
ASN A 295
TYR A 402
 None
G39  A1470 ( 4.3A)
G39  A1470 (-2.9A)
G39  A1470 ( 3.7A)
G39  A1470 (-4.5A)
 1.26A 3ti5A-4b7jA:
75.7		 3ti5A-4b7jA:
98.97
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3TI5_A_ZMRA1002_1
(NEURAMINIDASE)		 4hzz NEURAMINIDASE
(Influenza
A
virus) 		9 / 12 ARG A 118
GLU A 119
ASP A 151
ARG A 224
GLU A 227
GLU A 276
GLU A 277
ARG A 371
TYR A 406
 G39  A 509 (-3.0A)
G39  A 509 (-3.3A)
G39  A 509 (-3.6A)
G39  A 509 (-4.7A)
None
G39  A 509 ( 4.1A)
G39  A 509 ( 4.0A)
G39  A 509 (-2.9A)
G39  A 509 (-4.6A)
 0.57A 3ti5A-4hzzA:
63.7		 3ti5A-4hzzA:
47.72
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3TI5_A_ZMRA1002_1
(NEURAMINIDASE)		 4hzz NEURAMINIDASE
(Influenza
A
virus) 		9 / 12 ARG A 118
GLU A 119
ASP A 151
ARG A 224
GLU A 227
GLU A 277
ARG A 292
ARG A 371
TYR A 406
 G39  A 509 (-3.0A)
G39  A 509 (-3.3A)
G39  A 509 (-3.6A)
G39  A 509 (-4.7A)
None
G39  A 509 ( 4.0A)
G39  A 509 (-2.8A)
G39  A 509 (-2.9A)
G39  A 509 (-4.6A)
 0.28A 3ti5A-4hzzA:
63.7		 3ti5A-4hzzA:
47.72
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3TI5_A_ZMRA1002_1
(NEURAMINIDASE)		 4hzz NEURAMINIDASE
(Influenza
A
virus) 		7 / 12 GLU A 119
ARG A 224
GLU A 227
GLU A 276
GLU A 277
ASN A 294
TYR A 406
 G39  A 509 (-3.3A)
G39  A 509 (-4.7A)
None
G39  A 509 ( 4.1A)
G39  A 509 ( 4.0A)
G39  A 509 ( 4.4A)
G39  A 509 (-4.6A)
 0.96A 3ti5A-4hzzA:
63.7		 3ti5A-4hzzA:
47.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TI5_A_ZMRA1002_1
(NEURAMINIDASE)		 4yw5 NEURAMINIDASE C
(Streptococcus
pneumoniae) 		6 / 12 ARG A 290
ASP A 315
GLU A 584
ARG A 600
ARG A 662
TYR A 695
 G39  A 801 (-2.6A)
G39  A 801 (-3.2A)
G39  A 801 ( 4.7A)
G39  A 801 (-2.9A)
G39  A 801 (-2.9A)
G39  A 801 (-4.4A)
 0.75A 3ti5A-4yw5A:
4.5		 3ti5A-4yw5A:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TI5_A_ZMRA1002_1
(NEURAMINIDASE)		 6eks SIALIDASE
(Vibrio
cholerae) 		6 / 12 ARG A 250
ASP A 276
GLU A 645
ARG A 661
ARG A 738
TYR A 766
 G39  A 908 (-2.8A)
G39  A 908 (-3.3A)
G39  A 908 (-4.0A)
G39  A 908 (-2.8A)
G39  A 908 (-3.0A)
G39  A 908 (-4.6A)
 0.43A 3ti5A-6eksA:
20.9		 3ti5A-6eksA:
20.39
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3TI5_A_ZMRA1002_2
(NEURAMINIDASE)		 4hzz NEURAMINIDASE
(Influenza
A
virus) 		4 / 4 ARG A 152
ARG A 156
TRP A 178
ILE A 222
 G39  A 509 (-3.9A)
None
None
G39  A 509 ( 4.1A)
 0.18A 3ti5A-4hzzA:
63.7		 3ti5A-4hzzA:
47.72
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3TI5_B_ZMRB1002_1
(NEURAMINIDASE)		 4b7j NEURAMINIDASE
(Influenza
A
virus) 		12 / 12 ARG A 118
GLU A 119
ASP A 151
ARG A 225
GLU A 228
SER A 247
GLU A 277
GLU A 278
ARG A 293
ASN A 295
ARG A 368
TYR A 402
 G39  A1470 (-3.1A)
G39  A1470 (-3.5A)
G39  A1470 (-3.7A)
G39  A1470 (-4.4A)
None
G39  A1470 ( 4.3A)
G39  A1470 (-3.7A)
G39  A1470 (-4.2A)
G39  A1470 (-2.9A)
G39  A1470 ( 3.7A)
G39  A1470 (-3.0A)
G39  A1470 (-4.5A)
 0.54A 3ti5B-4b7jA:
75.8		 3ti5B-4b7jA:
98.97
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3TI5_B_ZMRB1002_1
(NEURAMINIDASE)		 4b7j NEURAMINIDASE
(Influenza
A
virus) 		5 / 12 GLU A 228
SER A 247
ARG A 293
ASN A 295
TYR A 402
 None
G39  A1470 ( 4.3A)
G39  A1470 (-2.9A)
G39  A1470 ( 3.7A)
G39  A1470 (-4.5A)
 1.25A 3ti5B-4b7jA:
75.8		 3ti5B-4b7jA:
98.97
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3TI5_B_ZMRB1002_1
(NEURAMINIDASE)		 4hzz NEURAMINIDASE
(Influenza
A
virus) 		9 / 12 ARG A 118
GLU A 119
ASP A 151
ARG A 224
GLU A 227
GLU A 276
GLU A 277
ARG A 371
TYR A 406
 G39  A 509 (-3.0A)
G39  A 509 (-3.3A)
G39  A 509 (-3.6A)
G39  A 509 (-4.7A)
None
G39  A 509 ( 4.1A)
G39  A 509 ( 4.0A)
G39  A 509 (-2.9A)
G39  A 509 (-4.6A)
 0.56A 3ti5B-4hzzA:
63.7		 3ti5B-4hzzA:
47.72
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3TI5_B_ZMRB1002_1
(NEURAMINIDASE)		 4hzz NEURAMINIDASE
(Influenza
A
virus) 		9 / 12 ARG A 118
GLU A 119
ASP A 151
ARG A 224
GLU A 227
GLU A 277
ARG A 292
ARG A 371
TYR A 406
 G39  A 509 (-3.0A)
G39  A 509 (-3.3A)
G39  A 509 (-3.6A)
G39  A 509 (-4.7A)
None
G39  A 509 ( 4.0A)
G39  A 509 (-2.8A)
G39  A 509 (-2.9A)
G39  A 509 (-4.6A)
 0.28A 3ti5B-4hzzA:
63.7		 3ti5B-4hzzA:
47.72
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3TI5_B_ZMRB1002_1
(NEURAMINIDASE)		 4hzz NEURAMINIDASE
(Influenza
A
virus) 		7 / 12 GLU A 119
ARG A 224
GLU A 227
GLU A 276
GLU A 277
ASN A 294
TYR A 406
 G39  A 509 (-3.3A)
G39  A 509 (-4.7A)
None
G39  A 509 ( 4.1A)
G39  A 509 ( 4.0A)
G39  A 509 ( 4.4A)
G39  A 509 (-4.6A)
 0.95A 3ti5B-4hzzA:
63.7		 3ti5B-4hzzA:
47.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TI5_B_ZMRB1002_1
(NEURAMINIDASE)		 4yw5 NEURAMINIDASE C
(Streptococcus
pneumoniae) 		6 / 12 ARG A 290
ASP A 315
GLU A 584
ARG A 600
ARG A 662
TYR A 695
 G39  A 801 (-2.6A)
G39  A 801 (-3.2A)
G39  A 801 ( 4.7A)
G39  A 801 (-2.9A)
G39  A 801 (-2.9A)
G39  A 801 (-4.4A)
 0.77A 3ti5B-4yw5A:
9.9		 3ti5B-4yw5A:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TI5_B_ZMRB1002_1
(NEURAMINIDASE)		 6eks SIALIDASE
(Vibrio
cholerae) 		6 / 12 ARG A 250
ASP A 276
GLU A 645
ARG A 661
ARG A 738
TYR A 766
 G39  A 908 (-2.8A)
G39  A 908 (-3.3A)
G39  A 908 (-4.0A)
G39  A 908 (-2.8A)
G39  A 908 (-3.0A)
G39  A 908 (-4.6A)
 0.45A 3ti5B-6eksA:
20.9		 3ti5B-6eksA:
20.39
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3TI5_B_ZMRB1002_2
(NEURAMINIDASE)		 4hzz NEURAMINIDASE
(Influenza
A
virus) 		4 / 4 ARG A 152
ARG A 156
TRP A 178
ILE A 222
 G39  A 509 (-3.9A)
None
None
G39  A 509 ( 4.1A)
 0.16A 3ti5B-4hzzA:
63.7		 3ti5B-4hzzA:
47.72
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3TIC_A_ZMRA1002_1
(NEURAMINIDASE)		 4b7j NEURAMINIDASE
(Influenza
A
virus) 		10 / 12 ARG A 118
GLU A 119
ASP A 151
TRP A 179
GLU A 228
GLU A 277
GLU A 278
ARG A 293
ARG A 368
TYR A 402
 G39  A1470 (-3.1A)
G39  A1470 (-3.5A)
G39  A1470 (-3.7A)
None
None
G39  A1470 (-3.7A)
G39  A1470 (-4.2A)
G39  A1470 (-2.9A)
G39  A1470 (-3.0A)
G39  A1470 (-4.5A)
 0.61A 3ticA-4b7jA:
64.0		 3ticA-4b7jA:
45.55
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3TIC_A_ZMRA1002_1
(NEURAMINIDASE)		 4b7j NEURAMINIDASE
(Influenza
A
virus) 		10 / 12 ARG A 118
GLU A 119
ASP A 151
TRP A 179
GLU A 228
GLU A 278
ARG A 293
ASN A 295
ARG A 368
TYR A 402
 G39  A1470 (-3.1A)
G39  A1470 (-3.5A)
G39  A1470 (-3.7A)
None
None
G39  A1470 (-4.2A)
G39  A1470 (-2.9A)
G39  A1470 ( 3.7A)
G39  A1470 (-3.0A)
G39  A1470 (-4.5A)
 0.45A 3ticA-4b7jA:
64.0		 3ticA-4b7jA:
45.55
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3TIC_A_ZMRA1002_1
(NEURAMINIDASE)		 4hzz NEURAMINIDASE
(Influenza
A
virus) 		10 / 12 ARG A 118
GLU A 119
ASP A 151
TRP A 178
GLU A 227
ALA A 246
GLU A 276
GLU A 277
ARG A 371
TYR A 406
 G39  A 509 (-3.0A)
G39  A 509 (-3.3A)
G39  A 509 (-3.6A)
None
None
G39  A 509 ( 4.1A)
G39  A 509 ( 4.1A)
G39  A 509 ( 4.0A)
G39  A 509 (-2.9A)
G39  A 509 (-4.6A)
 0.59A 3ticA-4hzzA:
64.7		 3ticA-4hzzA:
45.57
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3TIC_A_ZMRA1002_1
(NEURAMINIDASE)		 4hzz NEURAMINIDASE
(Influenza
A
virus) 		10 / 12 ARG A 118
GLU A 119
ASP A 151
TRP A 178
GLU A 227
ALA A 246
GLU A 277
ARG A 292
ARG A 371
TYR A 406
 G39  A 509 (-3.0A)
G39  A 509 (-3.3A)
G39  A 509 (-3.6A)
None
None
G39  A 509 ( 4.1A)
G39  A 509 ( 4.0A)
G39  A 509 (-2.8A)
G39  A 509 (-2.9A)
G39  A 509 (-4.6A)
 0.37A 3ticA-4hzzA:
64.7		 3ticA-4hzzA:
45.57
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3TIC_A_ZMRA1002_1
(NEURAMINIDASE)		 4hzz NEURAMINIDASE
(Influenza
A
virus) 		9 / 12 GLU A 119
ASP A 151
TRP A 178
GLU A 227
ALA A 246
GLU A 276
GLU A 277
ASN A 294
TYR A 406
 G39  A 509 (-3.3A)
G39  A 509 (-3.6A)
None
None
G39  A 509 ( 4.1A)
G39  A 509 ( 4.1A)
G39  A 509 ( 4.0A)
G39  A 509 ( 4.4A)
G39  A 509 (-4.6A)
 0.87A 3ticA-4hzzA:
64.7		 3ticA-4hzzA:
45.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TIC_A_ZMRA1002_1
(NEURAMINIDASE)		 4yw5 NEURAMINIDASE C
(Streptococcus
pneumoniae) 		6 / 12 ARG A 290
ASP A 315
GLU A 584
ARG A 600
ARG A 662
TYR A 695
 G39  A 801 (-2.6A)
G39  A 801 (-3.2A)
G39  A 801 ( 4.7A)
G39  A 801 (-2.9A)
G39  A 801 (-2.9A)
G39  A 801 (-4.4A)
 0.69A 3ticA-4yw5A:
7.5		 3ticA-4yw5A:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TIC_A_ZMRA1002_1
(NEURAMINIDASE)		 6eks SIALIDASE
(Vibrio
cholerae) 		7 / 12 ARG A 250
ASP A 276
TRP A 337
GLU A 645
ARG A 661
ARG A 738
TYR A 766
 G39  A 908 (-2.8A)
G39  A 908 (-3.3A)
None
G39  A 908 (-4.0A)
G39  A 908 (-2.8A)
G39  A 908 (-3.0A)
G39  A 908 (-4.6A)
 0.65A 3ticA-6eksA:
21.0		 3ticA-6eksA:
20.91
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3TIC_A_ZMRA1002_2
(NEURAMINIDASE)		 4b7j NEURAMINIDASE
(Influenza
A
virus) 		4 / 5 LEU A 134
ARG A 152
ARG A 156
ARG A 225
 None
G39  A1470 (-3.9A)
None
G39  A1470 (-4.4A)
 0.26A 3ticA-4b7jA:
64.0		 3ticA-4b7jA:
45.55
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3TIC_A_ZMRA1002_2
(NEURAMINIDASE)		 4hzz NEURAMINIDASE
(Influenza
A
virus) 		5 / 5 LEU A 134
ARG A 152
ARG A 156
ILE A 222
ARG A 224
 None
G39  A 509 (-3.9A)
None
G39  A 509 ( 4.1A)
G39  A 509 (-4.7A)
 0.18A 3ticA-4hzzA:
64.7		 3ticA-4hzzA:
45.57
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3TIC_B_ZMRB1002_1
(NEURAMINIDASE)		 4b7j NEURAMINIDASE
(Influenza
A
virus) 		10 / 12 ARG A 118
GLU A 119
ASP A 151
ARG A 225
GLU A 228
GLU A 277
GLU A 278
ARG A 293
ARG A 368
TYR A 402
 G39  A1470 (-3.1A)
G39  A1470 (-3.5A)
G39  A1470 (-3.7A)
G39  A1470 (-4.4A)
None
G39  A1470 (-3.7A)
G39  A1470 (-4.2A)
G39  A1470 (-2.9A)
G39  A1470 (-3.0A)
G39  A1470 (-4.5A)
 0.62A 3ticB-4b7jA:
63.9		 3ticB-4b7jA:
45.55
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3TIC_B_ZMRB1002_1
(NEURAMINIDASE)		 4b7j NEURAMINIDASE
(Influenza
A
virus) 		10 / 12 ARG A 118
GLU A 119
ASP A 151
ARG A 225
GLU A 228
GLU A 278
ARG A 293
ASN A 295
ARG A 368
TYR A 402
 G39  A1470 (-3.1A)
G39  A1470 (-3.5A)
G39  A1470 (-3.7A)
G39  A1470 (-4.4A)
None
G39  A1470 (-4.2A)
G39  A1470 (-2.9A)
G39  A1470 ( 3.7A)
G39  A1470 (-3.0A)
G39  A1470 (-4.5A)
 0.46A 3ticB-4b7jA:
63.9		 3ticB-4b7jA:
45.55
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3TIC_B_ZMRB1002_1
(NEURAMINIDASE)		 4hzz NEURAMINIDASE
(Influenza
A
virus) 		10 / 12 ARG A 118
GLU A 119
ASP A 151
ARG A 224
GLU A 227
ALA A 246
GLU A 276
GLU A 277
ARG A 371
TYR A 406
 G39  A 509 (-3.0A)
G39  A 509 (-3.3A)
G39  A 509 (-3.6A)
G39  A 509 (-4.7A)
None
G39  A 509 ( 4.1A)
G39  A 509 ( 4.1A)
G39  A 509 ( 4.0A)
G39  A 509 (-2.9A)
G39  A 509 (-4.6A)
 0.58A 3ticB-4hzzA:
64.6		 3ticB-4hzzA:
45.57
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3TIC_B_ZMRB1002_1
(NEURAMINIDASE)		 4hzz NEURAMINIDASE
(Influenza
A
virus) 		10 / 12 ARG A 118
GLU A 119
ASP A 151
ARG A 224
GLU A 227
ALA A 246
GLU A 277
ARG A 292
ARG A 371
TYR A 406
 G39  A 509 (-3.0A)
G39  A 509 (-3.3A)
G39  A 509 (-3.6A)
G39  A 509 (-4.7A)
None
G39  A 509 ( 4.1A)
G39  A 509 ( 4.0A)
G39  A 509 (-2.8A)
G39  A 509 (-2.9A)
G39  A 509 (-4.6A)
 0.38A 3ticB-4hzzA:
64.6		 3ticB-4hzzA:
45.57
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3TIC_B_ZMRB1002_1
(NEURAMINIDASE)		 4hzz NEURAMINIDASE
(Influenza
A
virus) 		9 / 12 GLU A 119
ASP A 151
ARG A 224
GLU A 227
ALA A 246
GLU A 276
GLU A 277
ASN A 294
TYR A 406
 G39  A 509 (-3.3A)
G39  A 509 (-3.6A)
G39  A 509 (-4.7A)
None
G39  A 509 ( 4.1A)
G39  A 509 ( 4.1A)
G39  A 509 ( 4.0A)
G39  A 509 ( 4.4A)
G39  A 509 (-4.6A)
 0.87A 3ticB-4hzzA:
64.6		 3ticB-4hzzA:
45.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TIC_B_ZMRB1002_1
(NEURAMINIDASE)		 4yw5 NEURAMINIDASE C
(Streptococcus
pneumoniae) 		6 / 12 ARG A 290
ASP A 315
GLU A 584
ARG A 600
ARG A 662
TYR A 695
 G39  A 801 (-2.6A)
G39  A 801 (-3.2A)
G39  A 801 ( 4.7A)
G39  A 801 (-2.9A)
G39  A 801 (-2.9A)
G39  A 801 (-4.4A)
 0.72A 3ticB-4yw5A:
20.5		 3ticB-4yw5A:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TIC_B_ZMRB1002_1
(NEURAMINIDASE)		 6eks SIALIDASE
(Vibrio
cholerae) 		6 / 12 ARG A 250
ASP A 276
GLU A 645
ARG A 661
ARG A 738
TYR A 766
 G39  A 908 (-2.8A)
G39  A 908 (-3.3A)
G39  A 908 (-4.0A)
G39  A 908 (-2.8A)
G39  A 908 (-3.0A)
G39  A 908 (-4.6A)
 0.47A 3ticB-6eksA:
21.0		 3ticB-6eksA:
20.91
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3TIC_B_ZMRB1002_2
(NEURAMINIDASE)		 4hzz NEURAMINIDASE
(Influenza
A
virus) 		4 / 4 ARG A 152
ARG A 156
TRP A 178
ILE A 222
 G39  A 509 (-3.9A)
None
None
G39  A 509 ( 4.1A)
 0.11A 3ticB-4hzzA:
64.6		 3ticB-4hzzA:
45.57
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3TIC_C_ZMRC1002_1
(NEURAMINIDASE)		 4b7j NEURAMINIDASE
(Influenza
A
virus) 		10 / 12 ARG A 118
GLU A 119
ASP A 151
ARG A 225
GLU A 228
GLU A 277
GLU A 278
ARG A 293
ARG A 368
TYR A 402
 G39  A1470 (-3.1A)
G39  A1470 (-3.5A)
G39  A1470 (-3.7A)
G39  A1470 (-4.4A)
None
G39  A1470 (-3.7A)
G39  A1470 (-4.2A)
G39  A1470 (-2.9A)
G39  A1470 (-3.0A)
G39  A1470 (-4.5A)
 0.63A 3ticC-4b7jA:
63.9		 3ticC-4b7jA:
45.55
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3TIC_C_ZMRC1002_1
(NEURAMINIDASE)		 4b7j NEURAMINIDASE
(Influenza
A
virus) 		10 / 12 ARG A 118
GLU A 119
ASP A 151
ARG A 225
GLU A 228
GLU A 278
ARG A 293
ASN A 295
ARG A 368
TYR A 402
 G39  A1470 (-3.1A)
G39  A1470 (-3.5A)
G39  A1470 (-3.7A)
G39  A1470 (-4.4A)
None
G39  A1470 (-4.2A)
G39  A1470 (-2.9A)
G39  A1470 ( 3.7A)
G39  A1470 (-3.0A)
G39  A1470 (-4.5A)
 0.47A 3ticC-4b7jA:
63.9		 3ticC-4b7jA:
45.55
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3TIC_C_ZMRC1002_1
(NEURAMINIDASE)		 4hzz NEURAMINIDASE
(Influenza
A
virus) 		9 / 12 ARG A 118
GLU A 119
ASP A 151
ARG A 224
GLU A 227
ALA A 246
GLU A 276
GLU A 277
TYR A 406
 G39  A 509 (-3.0A)
G39  A 509 (-3.3A)
G39  A 509 (-3.6A)
G39  A 509 (-4.7A)
None
G39  A 509 ( 4.1A)
G39  A 509 ( 4.1A)
G39  A 509 ( 4.0A)
G39  A 509 (-4.6A)
 0.58A 3ticC-4hzzA:
64.8		 3ticC-4hzzA:
45.57
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3TIC_C_ZMRC1002_1
(NEURAMINIDASE)		 4hzz NEURAMINIDASE
(Influenza
A
virus) 		10 / 12 ARG A 118
GLU A 119
ASP A 151
ARG A 224
GLU A 227
ALA A 246
GLU A 277
ARG A 292
ARG A 371
TYR A 406
 G39  A 509 (-3.0A)
G39  A 509 (-3.3A)
G39  A 509 (-3.6A)
G39  A 509 (-4.7A)
None
G39  A 509 ( 4.1A)
G39  A 509 ( 4.0A)
G39  A 509 (-2.8A)
G39  A 509 (-2.9A)
G39  A 509 (-4.6A)
 0.37A 3ticC-4hzzA:
64.8		 3ticC-4hzzA:
45.57
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3TIC_C_ZMRC1002_1
(NEURAMINIDASE)		 4hzz NEURAMINIDASE
(Influenza
A
virus) 		9 / 12 GLU A 119
ASP A 151
ARG A 224
GLU A 227
ALA A 246
GLU A 276
GLU A 277
ASN A 294
TYR A 406
 G39  A 509 (-3.3A)
G39  A 509 (-3.6A)
G39  A 509 (-4.7A)
None
G39  A 509 ( 4.1A)
G39  A 509 ( 4.1A)
G39  A 509 ( 4.0A)
G39  A 509 ( 4.4A)
G39  A 509 (-4.6A)
 0.87A 3ticC-4hzzA:
64.8		 3ticC-4hzzA:
45.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TIC_C_ZMRC1002_1
(NEURAMINIDASE)		 4yw5 NEURAMINIDASE C
(Streptococcus
pneumoniae) 		6 / 12 ARG A 290
ASP A 315
GLU A 584
ARG A 600
ARG A 662
TYR A 695
 G39  A 801 (-2.6A)
G39  A 801 (-3.2A)
G39  A 801 ( 4.7A)
G39  A 801 (-2.9A)
G39  A 801 (-2.9A)
G39  A 801 (-4.4A)
 0.70A 3ticC-4yw5A:
20.4		 3ticC-4yw5A:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TIC_C_ZMRC1002_1
(NEURAMINIDASE)		 6eks SIALIDASE
(Vibrio
cholerae) 		6 / 12 ARG A 250
ASP A 276
GLU A 645
ARG A 661
ARG A 738
TYR A 766
 G39  A 908 (-2.8A)
G39  A 908 (-3.3A)
G39  A 908 (-4.0A)
G39  A 908 (-2.8A)
G39  A 908 (-3.0A)
G39  A 908 (-4.6A)
 0.45A 3ticC-6eksA:
20.9		 3ticC-6eksA:
20.91
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3TIC_C_ZMRC1002_2
(NEURAMINIDASE)		 4hzz NEURAMINIDASE
(Influenza
A
virus) 		4 / 4 ARG A 152
ARG A 156
TRP A 178
ILE A 222
 G39  A 509 (-3.9A)
None
None
G39  A 509 ( 4.1A)
 0.12A 3ticC-4hzzA:
64.8		 3ticC-4hzzA:
45.57
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3TIC_D_ZMRD1002_1
(NEURAMINIDASE)		 4b7j NEURAMINIDASE
(Influenza
A
virus) 		10 / 12 ARG A 118
GLU A 119
ASP A 151
ARG A 225
GLU A 228
GLU A 277
GLU A 278
ARG A 293
ARG A 368
TYR A 402
 G39  A1470 (-3.1A)
G39  A1470 (-3.5A)
G39  A1470 (-3.7A)
G39  A1470 (-4.4A)
None
G39  A1470 (-3.7A)
G39  A1470 (-4.2A)
G39  A1470 (-2.9A)
G39  A1470 (-3.0A)
G39  A1470 (-4.5A)
 0.63A 3ticD-4b7jA:
64.0		 3ticD-4b7jA:
45.55
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3TIC_D_ZMRD1002_1
(NEURAMINIDASE)		 4b7j NEURAMINIDASE
(Influenza
A
virus) 		10 / 12 ARG A 118
GLU A 119
ASP A 151
ARG A 225
GLU A 228
GLU A 278
ARG A 293
ASN A 295
ARG A 368
TYR A 402
 G39  A1470 (-3.1A)
G39  A1470 (-3.5A)
G39  A1470 (-3.7A)
G39  A1470 (-4.4A)
None
G39  A1470 (-4.2A)
G39  A1470 (-2.9A)
G39  A1470 ( 3.7A)
G39  A1470 (-3.0A)
G39  A1470 (-4.5A)
 0.46A 3ticD-4b7jA:
64.0		 3ticD-4b7jA:
45.55
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3TIC_D_ZMRD1002_1
(NEURAMINIDASE)		 4hzz NEURAMINIDASE
(Influenza
A
virus) 		10 / 12 ARG A 118
GLU A 119
ASP A 151
ARG A 224
GLU A 227
ALA A 246
GLU A 276
GLU A 277
ARG A 371
TYR A 406
 G39  A 509 (-3.0A)
G39  A 509 (-3.3A)
G39  A 509 (-3.6A)
G39  A 509 (-4.7A)
None
G39  A 509 ( 4.1A)
G39  A 509 ( 4.1A)
G39  A 509 ( 4.0A)
G39  A 509 (-2.9A)
G39  A 509 (-4.6A)
 0.58A 3ticD-4hzzA:
64.7		 3ticD-4hzzA:
45.57
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3TIC_D_ZMRD1002_1
(NEURAMINIDASE)		 4hzz NEURAMINIDASE
(Influenza
A
virus) 		10 / 12 ARG A 118
GLU A 119
ASP A 151
ARG A 224
GLU A 227
ALA A 246
GLU A 277
ARG A 292
ARG A 371
TYR A 406
 G39  A 509 (-3.0A)
G39  A 509 (-3.3A)
G39  A 509 (-3.6A)
G39  A 509 (-4.7A)
None
G39  A 509 ( 4.1A)
G39  A 509 ( 4.0A)
G39  A 509 (-2.8A)
G39  A 509 (-2.9A)
G39  A 509 (-4.6A)
 0.37A 3ticD-4hzzA:
64.7		 3ticD-4hzzA:
45.57
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3TIC_D_ZMRD1002_1
(NEURAMINIDASE)		 4hzz NEURAMINIDASE
(Influenza
A
virus) 		9 / 12 GLU A 119
ASP A 151
ARG A 224
GLU A 227
ALA A 246
GLU A 276
GLU A 277
ASN A 294
TYR A 406
 G39  A 509 (-3.3A)
G39  A 509 (-3.6A)
G39  A 509 (-4.7A)
None
G39  A 509 ( 4.1A)
G39  A 509 ( 4.1A)
G39  A 509 ( 4.0A)
G39  A 509 ( 4.4A)
G39  A 509 (-4.6A)
 0.86A 3ticD-4hzzA:
64.7		 3ticD-4hzzA:
45.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TIC_D_ZMRD1002_1
(NEURAMINIDASE)		 4yw5 NEURAMINIDASE C
(Streptococcus
pneumoniae) 		6 / 12 ARG A 290
ASP A 315
GLU A 584
ARG A 600
ARG A 662
TYR A 695
 G39  A 801 (-2.6A)
G39  A 801 (-3.2A)
G39  A 801 ( 4.7A)
G39  A 801 (-2.9A)
G39  A 801 (-2.9A)
G39  A 801 (-4.4A)
 0.70A 3ticD-4yw5A:
20.6		 3ticD-4yw5A:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TIC_D_ZMRD1002_1
(NEURAMINIDASE)		 6eks SIALIDASE
(Vibrio
cholerae) 		6 / 12 ARG A 250
ASP A 276
GLU A 645
ARG A 661
ARG A 738
TYR A 766
 G39  A 908 (-2.8A)
G39  A 908 (-3.3A)
G39  A 908 (-4.0A)
G39  A 908 (-2.8A)
G39  A 908 (-3.0A)
G39  A 908 (-4.6A)
 0.45A 3ticD-6eksA:
20.9		 3ticD-6eksA:
20.91
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3TIC_D_ZMRD1002_2
(NEURAMINIDASE)		 4b7j NEURAMINIDASE
(Influenza
A
virus) 		4 / 5 LEU A 134
ARG A 152
ARG A 156
TRP A 179
 None
G39  A1470 (-3.9A)
None
None
 0.16A 3ticD-4b7jA:
64.0		 3ticD-4b7jA:
45.55
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3TIC_D_ZMRD1002_2
(NEURAMINIDASE)		 4hzz NEURAMINIDASE
(Influenza
A
virus) 		5 / 5 LEU A 134
ARG A 152
ARG A 156
TRP A 178
ILE A 222
 None
G39  A 509 (-3.9A)
None
None
G39  A 509 ( 4.1A)
 0.14A 3ticD-4hzzA:
64.7		 3ticD-4hzzA:
45.57
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4B7N_A_ZMRA601_1
(NEURAMINIDASE)		 4b7j NEURAMINIDASE
(Influenza
A
virus) 		12 / 12 ARG A 118
GLU A 119
ASP A 151
ARG A 225
GLU A 228
SER A 247
GLU A 277
GLU A 278
ARG A 293
ASN A 295
ARG A 368
TYR A 402
 G39  A1470 (-3.1A)
G39  A1470 (-3.5A)
G39  A1470 (-3.7A)
G39  A1470 (-4.4A)
None
G39  A1470 ( 4.3A)
G39  A1470 (-3.7A)
G39  A1470 (-4.2A)
G39  A1470 (-2.9A)
G39  A1470 ( 3.7A)
G39  A1470 (-3.0A)
G39  A1470 (-4.5A)
 0.52A 4b7nA-4b7jA:
75.4		 4b7nA-4b7jA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4B7N_A_ZMRA601_1
(NEURAMINIDASE)		 4hzz NEURAMINIDASE
(Influenza
A
virus) 		10 / 12 ARG A 118
GLU A 119
ASP A 151
ARG A 224
GLU A 227
GLU A 276
GLU A 277
ARG A 292
ARG A 371
TYR A 406
 G39  A 509 (-3.0A)
G39  A 509 (-3.3A)
G39  A 509 (-3.6A)
G39  A 509 (-4.7A)
None
G39  A 509 ( 4.1A)
G39  A 509 ( 4.0A)
G39  A 509 (-2.8A)
G39  A 509 (-2.9A)
G39  A 509 (-4.6A)
 0.55A 4b7nA-4hzzA:
63.3		 4b7nA-4hzzA:
40.42
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4B7N_A_ZMRA601_1
(NEURAMINIDASE)		 4hzz NEURAMINIDASE
(Influenza
A
virus) 		7 / 12 GLU A 119
ARG A 224
GLU A 227
GLU A 276
GLU A 277
ASN A 294
TYR A 406
 G39  A 509 (-3.3A)
G39  A 509 (-4.7A)
None
G39  A 509 ( 4.1A)
G39  A 509 ( 4.0A)
G39  A 509 ( 4.4A)
G39  A 509 (-4.6A)
 0.93A 4b7nA-4hzzA:
63.3		 4b7nA-4hzzA:
40.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4B7N_A_ZMRA601_1
(NEURAMINIDASE)		 4yw5 NEURAMINIDASE C
(Streptococcus
pneumoniae) 		6 / 12 ARG A 290
ASP A 315
GLU A 584
ARG A 600
ARG A 662
TYR A 695
 G39  A 801 (-2.6A)
G39  A 801 (-3.2A)
G39  A 801 ( 4.7A)
G39  A 801 (-2.9A)
G39  A 801 (-2.9A)
G39  A 801 (-4.4A)
 0.77A 4b7nA-4yw5A:
11.8		 4b7nA-4yw5A:
22.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4B7N_A_ZMRA601_1
(NEURAMINIDASE)		 6eks SIALIDASE
(Vibrio
cholerae) 		6 / 12 ARG A 250
ASP A 276
GLU A 645
ARG A 661
ARG A 738
TYR A 766
 G39  A 908 (-2.8A)
G39  A 908 (-3.3A)
G39  A 908 (-4.0A)
G39  A 908 (-2.8A)
G39  A 908 (-3.0A)
G39  A 908 (-4.6A)
 0.46A 4b7nA-6eksA:
12.4		 4b7nA-6eksA:
22.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4B7N_A_ZMRA601_1
(NEURAMINIDASE)		 6eks SIALIDASE
(Vibrio
cholerae) 		5 / 12 ARG A 738
GLU A 782
GLU A 269
ARG A 661
TYR A 766
 G39  A 908 (-3.0A)
None
G39  A 908 ( 4.7A)
G39  A 908 (-2.8A)
G39  A 908 (-4.6A)
 1.43A 4b7nA-6eksA:
12.4		 4b7nA-6eksA:
22.58
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4B7N_A_ZMRA601_2
(NEURAMINIDASE)		 4b7j NEURAMINIDASE
(Influenza
A
virus) 		3 / 3 ARG A 152
ARG A 156
TRP A 179
 G39  A1470 (-3.9A)
None
None
 0.11A 4b7nA-4b7jA:
75.4		 4b7nA-4b7jA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4B7N_A_ZMRA601_2
(NEURAMINIDASE)		 4hzz NEURAMINIDASE
(Influenza
A
virus) 		3 / 3 ARG A 152
ARG A 156
TRP A 178
 G39  A 509 (-3.9A)
None
None
 0.09A 4b7nA-4hzzA:
63.3		 4b7nA-4hzzA:
40.42
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4B7Q_A_ZMRA601_1
(NEURAMINIDASE)		 4b7j NEURAMINIDASE
(Influenza
A
virus) 		12 / 12 ARG A 118
GLU A 119
ASP A 151
ARG A 225
GLU A 228
SER A 247
GLU A 277
GLU A 278
ARG A 293
ASN A 295
ARG A 368
TYR A 402
 G39  A1470 (-3.1A)
G39  A1470 (-3.5A)
G39  A1470 (-3.7A)
G39  A1470 (-4.4A)
None
G39  A1470 ( 4.3A)
G39  A1470 (-3.7A)
G39  A1470 (-4.2A)
G39  A1470 (-2.9A)
G39  A1470 ( 3.7A)
G39  A1470 (-3.0A)
G39  A1470 (-4.5A)
 0.58A 4b7qA-4b7jA:
75.0		 4b7qA-4b7jA:
99.15
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4B7Q_A_ZMRA601_1
(NEURAMINIDASE)		 4hzz NEURAMINIDASE
(Influenza
A
virus) 		9 / 12 ARG A 118
GLU A 119
ASP A 151
ARG A 224
GLU A 227
GLU A 276
GLU A 277
ARG A 371
TYR A 406
 G39  A 509 (-3.0A)
G39  A 509 (-3.3A)
G39  A 509 (-3.6A)
G39  A 509 (-4.7A)
None
G39  A 509 ( 4.1A)
G39  A 509 ( 4.0A)
G39  A 509 (-2.9A)
G39  A 509 (-4.6A)
 0.60A 4b7qA-4hzzA:
63.3		 4b7qA-4hzzA:
40.42
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4B7Q_A_ZMRA601_1
(NEURAMINIDASE)		 4hzz NEURAMINIDASE
(Influenza
A
virus) 		9 / 12 ARG A 118
GLU A 119
ASP A 151
ARG A 224
GLU A 227
GLU A 277
ARG A 292
ARG A 371
TYR A 406
 G39  A 509 (-3.0A)
G39  A 509 (-3.3A)
G39  A 509 (-3.6A)
G39  A 509 (-4.7A)
None
G39  A 509 ( 4.0A)
G39  A 509 (-2.8A)
G39  A 509 (-2.9A)
G39  A 509 (-4.6A)
 0.32A 4b7qA-4hzzA:
63.3		 4b7qA-4hzzA:
40.42
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4B7Q_A_ZMRA601_1
(NEURAMINIDASE)		 4hzz NEURAMINIDASE
(Influenza
A
virus) 		7 / 12 GLU A 119
ARG A 224
GLU A 227
GLU A 276
GLU A 277
ASN A 294
TYR A 406
 G39  A 509 (-3.3A)
G39  A 509 (-4.7A)
None
G39  A 509 ( 4.1A)
G39  A 509 ( 4.0A)
G39  A 509 ( 4.4A)
G39  A 509 (-4.6A)
 0.96A 4b7qA-4hzzA:
63.3		 4b7qA-4hzzA:
40.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4B7Q_A_ZMRA601_1
(NEURAMINIDASE)		 4yw5 NEURAMINIDASE C
(Streptococcus
pneumoniae) 		6 / 12 ARG A 290
ASP A 315
GLU A 584
ARG A 600
ARG A 662
TYR A 695
 G39  A 801 (-2.6A)
G39  A 801 (-3.2A)
G39  A 801 ( 4.7A)
G39  A 801 (-2.9A)
G39  A 801 (-2.9A)
G39  A 801 (-4.4A)
 0.87A 4b7qA-4yw5A:
12.5		 4b7qA-4yw5A:
22.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4B7Q_A_ZMRA601_1
(NEURAMINIDASE)		 6eks SIALIDASE
(Vibrio
cholerae) 		6 / 12 ARG A 250
ASP A 276
GLU A 645
ARG A 661
ARG A 738
TYR A 766
 G39  A 908 (-2.8A)
G39  A 908 (-3.3A)
G39  A 908 (-4.0A)
G39  A 908 (-2.8A)
G39  A 908 (-3.0A)
G39  A 908 (-4.6A)
 0.57A 4b7qA-6eksA:
21.0		 4b7qA-6eksA:
22.86
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4B7Q_A_ZMRA601_2
(NEURAMINIDASE)		 4hzz NEURAMINIDASE
(Influenza
A
virus) 		3 / 3 ARG A 152
ARG A 156
ILE A 222
 G39  A 509 (-3.9A)
None
G39  A 509 ( 4.1A)
 0.22A 4b7qA-4hzzA:
63.3		 4b7qA-4hzzA:
40.42
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4B7Q_B_ZMRB601_1
(NEURAMINIDASE)		 4b7j NEURAMINIDASE
(Influenza
A
virus) 		12 / 12 ARG A 118
GLU A 119
ASP A 151
ARG A 225
GLU A 228
SER A 247
GLU A 277
GLU A 278
ARG A 293
ASN A 295
ARG A 368
TYR A 402
 G39  A1470 (-3.1A)
G39  A1470 (-3.5A)
G39  A1470 (-3.7A)
G39  A1470 (-4.4A)
None
G39  A1470 ( 4.3A)
G39  A1470 (-3.7A)
G39  A1470 (-4.2A)
G39  A1470 (-2.9A)
G39  A1470 ( 3.7A)
G39  A1470 (-3.0A)
G39  A1470 (-4.5A)
 0.60A 4b7qB-4b7jA:
74.9		 4b7qB-4b7jA:
99.15
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4B7Q_B_ZMRB601_1
(NEURAMINIDASE)		 4hzz NEURAMINIDASE
(Influenza
A
virus) 		10 / 12 ARG A 118
GLU A 119
ASP A 151
ARG A 224
GLU A 227
GLU A 276
GLU A 277
ARG A 292
ARG A 371
TYR A 406
 G39  A 509 (-3.0A)
G39  A 509 (-3.3A)
G39  A 509 (-3.6A)
G39  A 509 (-4.7A)
None
G39  A 509 ( 4.1A)
G39  A 509 ( 4.0A)
G39  A 509 (-2.8A)
G39  A 509 (-2.9A)
G39  A 509 (-4.6A)
 0.60A 4b7qB-4hzzA:
63.2		 4b7qB-4hzzA:
40.42
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4B7Q_B_ZMRB601_1
(NEURAMINIDASE)		 4hzz NEURAMINIDASE
(Influenza
A
virus) 		7 / 12 GLU A 119
ARG A 224
GLU A 227
GLU A 276
GLU A 277
ASN A 294
TYR A 406
 G39  A 509 (-3.3A)
G39  A 509 (-4.7A)
None
G39  A 509 ( 4.1A)
G39  A 509 ( 4.0A)
G39  A 509 ( 4.4A)
G39  A 509 (-4.6A)
 0.96A 4b7qB-4hzzA:
63.2		 4b7qB-4hzzA:
40.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4B7Q_B_ZMRB601_1
(NEURAMINIDASE)		 4yw5 NEURAMINIDASE C
(Streptococcus
pneumoniae) 		6 / 12 ARG A 290
ASP A 315
GLU A 584
ARG A 600
ARG A 662
TYR A 695
 G39  A 801 (-2.6A)
G39  A 801 (-3.2A)
G39  A 801 ( 4.7A)
G39  A 801 (-2.9A)
G39  A 801 (-2.9A)
G39  A 801 (-4.4A)
 0.80A 4b7qB-4yw5A:
3.0		 4b7qB-4yw5A:
22.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4B7Q_B_ZMRB601_1
(NEURAMINIDASE)		 6eks SIALIDASE
(Vibrio
cholerae) 		6 / 12 ARG A 250
ASP A 276
GLU A 645
ARG A 661
ARG A 738
TYR A 766
 G39  A 908 (-2.8A)
G39  A 908 (-3.3A)
G39  A 908 (-4.0A)
G39  A 908 (-2.8A)
G39  A 908 (-3.0A)
G39  A 908 (-4.6A)
 0.51A 4b7qB-6eksA:
11.6		 4b7qB-6eksA:
22.86
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4B7Q_B_ZMRB601_2
(NEURAMINIDASE)		 4b7j NEURAMINIDASE
(Influenza
A
virus) 		4 / 4 LEU A 134
ARG A 152
ARG A 156
TRP A 179
 None
G39  A1470 (-3.9A)
None
None
 0.17A 4b7qB-4b7jA:
74.9		 4b7qB-4b7jA:
99.15
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4B7Q_B_ZMRB601_2
(NEURAMINIDASE)		 4hzz NEURAMINIDASE
(Influenza
A
virus) 		4 / 4 LEU A 134
ARG A 152
ARG A 156
TRP A 178
 None
G39  A 509 (-3.9A)
None
None
 0.20A 4b7qB-4hzzA:
63.2		 4b7qB-4hzzA:
40.42
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4B7Q_C_ZMRC601_1
(NEURAMINIDASE)		 4b7j NEURAMINIDASE
(Influenza
A
virus) 		12 / 12 ARG A 118
GLU A 119
ASP A 151
ARG A 225
GLU A 228
SER A 247
GLU A 277
GLU A 278
ARG A 293
ASN A 295
ARG A 368
TYR A 402
 G39  A1470 (-3.1A)
G39  A1470 (-3.5A)
G39  A1470 (-3.7A)
G39  A1470 (-4.4A)
None
G39  A1470 ( 4.3A)
G39  A1470 (-3.7A)
G39  A1470 (-4.2A)
G39  A1470 (-2.9A)
G39  A1470 ( 3.7A)
G39  A1470 (-3.0A)
G39  A1470 (-4.5A)
 0.58A 4b7qC-4b7jA:
75.0		 4b7qC-4b7jA:
99.15
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4B7Q_C_ZMRC601_1
(NEURAMINIDASE)		 4b7j NEURAMINIDASE
(Influenza
A
virus) 		5 / 12 GLU A 228
SER A 247
ARG A 293
ASN A 295
TYR A 402
 None
G39  A1470 ( 4.3A)
G39  A1470 (-2.9A)
G39  A1470 ( 3.7A)
G39  A1470 (-4.5A)
 1.31A 4b7qC-4b7jA:
75.0		 4b7qC-4b7jA:
99.15
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4B7Q_C_ZMRC601_1
(NEURAMINIDASE)		 4hzz NEURAMINIDASE
(Influenza
A
virus) 		10 / 12 ARG A 118
GLU A 119
ASP A 151
ARG A 224
GLU A 227
GLU A 276
GLU A 277
ARG A 292
ARG A 371
TYR A 406
 G39  A 509 (-3.0A)
G39  A 509 (-3.3A)
G39  A 509 (-3.6A)
G39  A 509 (-4.7A)
None
G39  A 509 ( 4.1A)
G39  A 509 ( 4.0A)
G39  A 509 (-2.8A)
G39  A 509 (-2.9A)
G39  A 509 (-4.6A)
 0.57A 4b7qC-4hzzA:
63.1		 4b7qC-4hzzA:
40.42
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4B7Q_C_ZMRC601_1
(NEURAMINIDASE)		 4hzz NEURAMINIDASE
(Influenza
A
virus) 		7 / 12 GLU A 119
ARG A 224
GLU A 227
GLU A 276
GLU A 277
ASN A 294
TYR A 406
 G39  A 509 (-3.3A)
G39  A 509 (-4.7A)
None
G39  A 509 ( 4.1A)
G39  A 509 ( 4.0A)
G39  A 509 ( 4.4A)
G39  A 509 (-4.6A)
 0.99A 4b7qC-4hzzA:
63.1		 4b7qC-4hzzA:
40.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4B7Q_C_ZMRC601_1
(NEURAMINIDASE)		 4yw5 NEURAMINIDASE C
(Streptococcus
pneumoniae) 		6 / 12 ARG A 290
ASP A 315
GLU A 584
ARG A 600
ARG A 662
TYR A 695
 G39  A 801 (-2.6A)
G39  A 801 (-3.2A)
G39  A 801 ( 4.7A)
G39  A 801 (-2.9A)
G39  A 801 (-2.9A)
G39  A 801 (-4.4A)
 0.77A 4b7qC-4yw5A:
11.9		 4b7qC-4yw5A:
22.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4B7Q_C_ZMRC601_1
(NEURAMINIDASE)		 6eks SIALIDASE
(Vibrio
cholerae) 		6 / 12 ARG A 250
ASP A 276
GLU A 645
ARG A 661
ARG A 738
TYR A 766
 G39  A 908 (-2.8A)
G39  A 908 (-3.3A)
G39  A 908 (-4.0A)
G39  A 908 (-2.8A)
G39  A 908 (-3.0A)
G39  A 908 (-4.6A)
 0.48A 4b7qC-6eksA:
12.5		 4b7qC-6eksA:
22.86
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4B7Q_C_ZMRC601_2
(NEURAMINIDASE)		 4hzz NEURAMINIDASE
(Influenza
A
virus) 		3 / 3 ARG A 152
ARG A 156
ILE A 222
 G39  A 509 (-3.9A)
None
G39  A 509 ( 4.1A)
 0.24A 4b7qC-4hzzA:
63.1		 4b7qC-4hzzA:
40.42
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4B7Q_D_ZMRD601_1
(NEURAMINIDASE)		 4b7j NEURAMINIDASE
(Influenza
A
virus) 		12 / 12 ARG A 118
GLU A 119
ASP A 151
ARG A 225
GLU A 228
SER A 247
GLU A 277
GLU A 278
ARG A 293
ASN A 295
ARG A 368
TYR A 402
 G39  A1470 (-3.1A)
G39  A1470 (-3.5A)
G39  A1470 (-3.7A)
G39  A1470 (-4.4A)
None
G39  A1470 ( 4.3A)
G39  A1470 (-3.7A)
G39  A1470 (-4.2A)
G39  A1470 (-2.9A)
G39  A1470 ( 3.7A)
G39  A1470 (-3.0A)
G39  A1470 (-4.5A)
 0.60A 4b7qD-4b7jA:
74.6		 4b7qD-4b7jA:
99.15
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4B7Q_D_ZMRD601_1
(NEURAMINIDASE)		 4hzz NEURAMINIDASE
(Influenza
A
virus) 		9 / 12 ARG A 118
GLU A 119
ASP A 151
ARG A 224
GLU A 227
GLU A 276
GLU A 277
ARG A 371
TYR A 406
 G39  A 509 (-3.0A)
G39  A 509 (-3.3A)
G39  A 509 (-3.6A)
G39  A 509 (-4.7A)
None
G39  A 509 ( 4.1A)
G39  A 509 ( 4.0A)
G39  A 509 (-2.9A)
G39  A 509 (-4.6A)
 0.62A 4b7qD-4hzzA:
63.3		 4b7qD-4hzzA:
40.42
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4B7Q_D_ZMRD601_1
(NEURAMINIDASE)		 4hzz NEURAMINIDASE
(Influenza
A
virus) 		9 / 12 ARG A 118
GLU A 119
ASP A 151
ARG A 224
GLU A 227
GLU A 277
ARG A 292
ARG A 371
TYR A 406
 G39  A 509 (-3.0A)
G39  A 509 (-3.3A)
G39  A 509 (-3.6A)
G39  A 509 (-4.7A)
None
G39  A 509 ( 4.0A)
G39  A 509 (-2.8A)
G39  A 509 (-2.9A)
G39  A 509 (-4.6A)
 0.34A 4b7qD-4hzzA:
63.3		 4b7qD-4hzzA:
40.42
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4B7Q_D_ZMRD601_1
(NEURAMINIDASE)		 4hzz NEURAMINIDASE
(Influenza
A
virus) 		7 / 12 GLU A 119
ARG A 224
GLU A 227
GLU A 276
GLU A 277
ASN A 294
TYR A 406
 G39  A 509 (-3.3A)
G39  A 509 (-4.7A)
None
G39  A 509 ( 4.1A)
G39  A 509 ( 4.0A)
G39  A 509 ( 4.4A)
G39  A 509 (-4.6A)
 0.98A 4b7qD-4hzzA:
63.3		 4b7qD-4hzzA:
40.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4B7Q_D_ZMRD601_1
(NEURAMINIDASE)		 4yw5 NEURAMINIDASE C
(Streptococcus
pneumoniae) 		6 / 12 ARG A 290
ASP A 315
GLU A 584
ARG A 600
ARG A 662
TYR A 695
 G39  A 801 (-2.6A)
G39  A 801 (-3.2A)
G39  A 801 ( 4.7A)
G39  A 801 (-2.9A)
G39  A 801 (-2.9A)
G39  A 801 (-4.4A)
 0.84A 4b7qD-4yw5A:
11.9		 4b7qD-4yw5A:
22.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4B7Q_D_ZMRD601_1
(NEURAMINIDASE)		 6eks SIALIDASE
(Vibrio
cholerae) 		6 / 12 ARG A 250
ASP A 276
GLU A 645
ARG A 661
ARG A 738
TYR A 766
 G39  A 908 (-2.8A)
G39  A 908 (-3.3A)
G39  A 908 (-4.0A)
G39  A 908 (-2.8A)
G39  A 908 (-3.0A)
G39  A 908 (-4.6A)
 0.50A 4b7qD-6eksA:
20.9		 4b7qD-6eksA:
22.86
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4B7Q_D_ZMRD601_2
(NEURAMINIDASE)		 4hzz NEURAMINIDASE
(Influenza
A
virus) 		4 / 4 ARG A 152
ARG A 156
TRP A 178
ILE A 222
 G39  A 509 (-3.9A)
None
None
G39  A 509 ( 4.1A)
 0.28A 4b7qD-4hzzA:
63.3		 4b7qD-4hzzA:
40.42
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4CPN_A_ZMRA700_1
(NEURAMINIDASE)		 4b7j NEURAMINIDASE
(Influenza
A
virus) 		11 / 12 ARG A 118
GLU A 119
ASP A 151
ARG A 225
GLU A 228
GLU A 277
GLU A 278
ARG A 293
ASN A 295
ARG A 368
TYR A 402
 G39  A1470 (-3.1A)
G39  A1470 (-3.5A)
G39  A1470 (-3.7A)
G39  A1470 (-4.4A)
None
G39  A1470 (-3.7A)
G39  A1470 (-4.2A)
G39  A1470 (-2.9A)
G39  A1470 ( 3.7A)
G39  A1470 (-3.0A)
G39  A1470 (-4.5A)
 0.65A 4cpnA-4b7jA:
53.2		 4cpnA-4b7jA:
34.16
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4CPN_A_ZMRA700_1
(NEURAMINIDASE)		 4hzz NEURAMINIDASE
(Influenza
A
virus) 		9 / 12 ARG A 118
GLU A 119
ASP A 151
ARG A 224
GLU A 227
ALA A 246
GLU A 276
GLU A 277
TYR A 406
 G39  A 509 (-3.0A)
G39  A 509 (-3.3A)
G39  A 509 (-3.6A)
G39  A 509 (-4.7A)
None
G39  A 509 ( 4.1A)
G39  A 509 ( 4.1A)
G39  A 509 ( 4.0A)
G39  A 509 (-4.6A)
 0.64A 4cpnA-4hzzA:
52.5		 4cpnA-4hzzA:
30.62
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4CPN_A_ZMRA700_1
(NEURAMINIDASE)		 4hzz NEURAMINIDASE
(Influenza
A
virus) 		10 / 12 ARG A 118
GLU A 119
ASP A 151
ARG A 224
GLU A 227
ALA A 246
GLU A 277
ARG A 292
ARG A 371
TYR A 406
 G39  A 509 (-3.0A)
G39  A 509 (-3.3A)
G39  A 509 (-3.6A)
G39  A 509 (-4.7A)
None
G39  A 509 ( 4.1A)
G39  A 509 ( 4.0A)
G39  A 509 (-2.8A)
G39  A 509 (-2.9A)
G39  A 509 (-4.6A)
 0.54A 4cpnA-4hzzA:
52.5		 4cpnA-4hzzA:
30.62
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4CPN_A_ZMRA700_1
(NEURAMINIDASE)		 4hzz NEURAMINIDASE
(Influenza
A
virus) 		8 / 12 GLU A 119
ARG A 224
GLU A 227
ALA A 246
GLU A 276
GLU A 277
ASN A 294
TYR A 406
 G39  A 509 (-3.3A)
G39  A 509 (-4.7A)
None
G39  A 509 ( 4.1A)
G39  A 509 ( 4.1A)
G39  A 509 ( 4.0A)
G39  A 509 ( 4.4A)
G39  A 509 (-4.6A)
 1.01A 4cpnA-4hzzA:
52.5		 4cpnA-4hzzA:
30.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CPN_A_ZMRA700_1
(NEURAMINIDASE)		 4yw5 NEURAMINIDASE C
(Streptococcus
pneumoniae) 		6 / 12 ARG A 290
ASP A 315
GLU A 584
ARG A 600
ARG A 662
TYR A 695
 G39  A 801 (-2.6A)
G39  A 801 (-3.2A)
G39  A 801 ( 4.7A)
G39  A 801 (-2.9A)
G39  A 801 (-2.9A)
G39  A 801 (-4.4A)
 0.78A 4cpnA-4yw5A:
23.9		 4cpnA-4yw5A:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CPN_A_ZMRA700_1
(NEURAMINIDASE)		 6eks SIALIDASE
(Vibrio
cholerae) 		6 / 12 ARG A 250
ASP A 276
GLU A 645
ARG A 661
ARG A 738
TYR A 766
 G39  A 908 (-2.8A)
G39  A 908 (-3.3A)
G39  A 908 (-4.0A)
G39  A 908 (-2.8A)
G39  A 908 (-3.0A)
G39  A 908 (-4.6A)
 0.52A 4cpnA-6eksA:
24.9		 4cpnA-6eksA:
21.39
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4CPN_A_ZMRA700_2
(NEURAMINIDASE)		 4hzz NEURAMINIDASE
(Influenza
A
virus) 		4 / 4 ARG A 152
ARG A 156
TRP A 178
ILE A 222
 G39  A 509 (-3.9A)
None
None
G39  A 509 ( 4.1A)
 0.14A 4cpnA-4hzzA:
52.5		 4cpnA-4hzzA:
30.62
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4CPN_B_ZMRB700_1
(NEURAMINIDASE)		 4b7j NEURAMINIDASE
(Influenza
A
virus) 		11 / 12 ARG A 118
GLU A 119
ASP A 151
ARG A 156
ARG A 225
GLU A 228
GLU A 277
GLU A 278
ARG A 293
ARG A 368
TYR A 402
 G39  A1470 (-3.1A)
G39  A1470 (-3.5A)
G39  A1470 (-3.7A)
None
G39  A1470 (-4.4A)
None
G39  A1470 (-3.7A)
G39  A1470 (-4.2A)
G39  A1470 (-2.9A)
G39  A1470 (-3.0A)
G39  A1470 (-4.5A)
 0.64A 4cpnB-4b7jA:
53.1		 4cpnB-4b7jA:
34.16
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4CPN_B_ZMRB700_1
(NEURAMINIDASE)		 4hzz NEURAMINIDASE
(Influenza
A
virus) 		10 / 12 ARG A 118
GLU A 119
ASP A 151
ARG A 156
ARG A 224
GLU A 227
ALA A 246
GLU A 276
GLU A 277
TYR A 406
 G39  A 509 (-3.0A)
G39  A 509 (-3.3A)
G39  A 509 (-3.6A)
None
G39  A 509 (-4.7A)
None
G39  A 509 ( 4.1A)
G39  A 509 ( 4.1A)
G39  A 509 ( 4.0A)
G39  A 509 (-4.6A)
 0.60A 4cpnB-4hzzA:
52.4		 4cpnB-4hzzA:
30.62
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4CPN_B_ZMRB700_1
(NEURAMINIDASE)		 4hzz NEURAMINIDASE
(Influenza
A
virus) 		11 / 12 ARG A 118
GLU A 119
ASP A 151
ARG A 156
ARG A 224
GLU A 227
ALA A 246
GLU A 277
ARG A 292
ARG A 371
TYR A 406
 G39  A 509 (-3.0A)
G39  A 509 (-3.3A)
G39  A 509 (-3.6A)
None
G39  A 509 (-4.7A)
None
G39  A 509 ( 4.1A)
G39  A 509 ( 4.0A)
G39  A 509 (-2.8A)
G39  A 509 (-2.9A)
G39  A 509 (-4.6A)
 0.44A 4cpnB-4hzzA:
52.4		 4cpnB-4hzzA:
30.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CPN_B_ZMRB700_1
(NEURAMINIDASE)		 4yw5 NEURAMINIDASE C
(Streptococcus
pneumoniae) 		6 / 12 ARG A 290
ASP A 315
GLU A 584
ARG A 600
ARG A 662
TYR A 695
 G39  A 801 (-2.6A)
G39  A 801 (-3.2A)
G39  A 801 ( 4.7A)
G39  A 801 (-2.9A)
G39  A 801 (-2.9A)
G39  A 801 (-4.4A)
 0.81A 4cpnB-4yw5A:
3.3		 4cpnB-4yw5A:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CPN_B_ZMRB700_1
(NEURAMINIDASE)		 6eks SIALIDASE
(Vibrio
cholerae) 		6 / 12 ARG A 250
ASP A 276
GLU A 645
ARG A 661
ARG A 738
TYR A 766
 G39  A 908 (-2.8A)
G39  A 908 (-3.3A)
G39  A 908 (-4.0A)
G39  A 908 (-2.8A)
G39  A 908 (-3.0A)
G39  A 908 (-4.6A)
 0.49A 4cpnB-6eksA:
25.0		 4cpnB-6eksA:
21.39
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4CPZ_A_ZMRA1471_1
(NEURAMINIDASE)		 4b7j NEURAMINIDASE
(Influenza
A
virus) 		8 / 12 ARG A 118
GLU A 119
ARG A 225
GLU A 228
GLU A 277
GLU A 278
ASN A 295
TYR A 402
 G39  A1470 (-3.1A)
G39  A1470 (-3.5A)
G39  A1470 (-4.4A)
None
G39  A1470 (-3.7A)
G39  A1470 (-4.2A)
G39  A1470 ( 3.7A)
G39  A1470 (-4.5A)
 0.73A 4cpzA-4b7jA:
52.9		 4cpzA-4b7jA:
33.95
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4CPZ_A_ZMRA1471_1
(NEURAMINIDASE)		 4b7j NEURAMINIDASE
(Influenza
A
virus) 		9 / 12 ARG A 118
GLU A 119
ARG A 225
GLU A 228
GLU A 278
ARG A 293
ASN A 295
ARG A 368
TYR A 402
 G39  A1470 (-3.1A)
G39  A1470 (-3.5A)
G39  A1470 (-4.4A)
None
G39  A1470 (-4.2A)
G39  A1470 (-2.9A)
G39  A1470 ( 3.7A)
G39  A1470 (-3.0A)
G39  A1470 (-4.5A)
 0.47A 4cpzA-4b7jA:
52.9		 4cpzA-4b7jA:
33.95
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4CPZ_A_ZMRA1471_1
(NEURAMINIDASE)		 4hzz NEURAMINIDASE
(Influenza
A
virus) 		8 / 12 ARG A 118
GLU A 119
ARG A 224
GLU A 227
ALA A 246
GLU A 276
GLU A 277
TYR A 406
 G39  A 509 (-3.0A)
G39  A 509 (-3.3A)
G39  A 509 (-4.7A)
None
G39  A 509 ( 4.1A)
G39  A 509 ( 4.1A)
G39  A 509 ( 4.0A)
G39  A 509 (-4.6A)
 0.72A 4cpzA-4hzzA:
52.3		 4cpzA-4hzzA:
30.42
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4CPZ_A_ZMRA1471_1
(NEURAMINIDASE)		 4hzz NEURAMINIDASE
(Influenza
A
virus) 		9 / 12 ARG A 118
GLU A 119
ARG A 224
GLU A 227
ALA A 246
GLU A 277
ARG A 292
ARG A 371
TYR A 406
 G39  A 509 (-3.0A)
G39  A 509 (-3.3A)
G39  A 509 (-4.7A)
None
G39  A 509 ( 4.1A)
G39  A 509 ( 4.0A)
G39  A 509 (-2.8A)
G39  A 509 (-2.9A)
G39  A 509 (-4.6A)
 0.53A 4cpzA-4hzzA:
52.3		 4cpzA-4hzzA:
30.42
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4CPZ_A_ZMRA1471_1
(NEURAMINIDASE)		 4hzz NEURAMINIDASE
(Influenza
A
virus) 		8 / 12 GLU A 119
ARG A 224
GLU A 227
ALA A 246
GLU A 276
GLU A 277
ASN A 294
TYR A 406
 G39  A 509 (-3.3A)
G39  A 509 (-4.7A)
None
G39  A 509 ( 4.1A)
G39  A 509 ( 4.1A)
G39  A 509 ( 4.0A)
G39  A 509 ( 4.4A)
G39  A 509 (-4.6A)
 1.01A 4cpzA-4hzzA:
52.3		 4cpzA-4hzzA:
30.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CPZ_A_ZMRA1471_1
(NEURAMINIDASE)		 4yw5 NEURAMINIDASE C
(Streptococcus
pneumoniae) 		5 / 12 ARG A 290
GLU A 584
ARG A 600
ARG A 662
TYR A 695
 G39  A 801 (-2.6A)
G39  A 801 ( 4.7A)
G39  A 801 (-2.9A)
G39  A 801 (-2.9A)
G39  A 801 (-4.4A)
 0.43A 4cpzA-4yw5A:
24.0		 4cpzA-4yw5A:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CPZ_A_ZMRA1471_1
(NEURAMINIDASE)		 6eks SIALIDASE
(Vibrio
cholerae) 		5 / 12 ARG A 250
GLU A 645
ARG A 661
ARG A 738
TYR A 766
 G39  A 908 (-2.8A)
G39  A 908 (-4.0A)
G39  A 908 (-2.8A)
G39  A 908 (-3.0A)
G39  A 908 (-4.6A)
 0.34A 4cpzA-6eksA:
24.9		 4cpzA-6eksA:
20.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CPZ_A_ZMRA1471_1
(NEURAMINIDASE)		 6eks SIALIDASE
(Vibrio
cholerae) 		5 / 12 ARG A 250
LEU A 606
GLU A 645
ARG A 738
TYR A 766
 G39  A 908 (-2.8A)
None
G39  A 908 (-4.0A)
G39  A 908 (-3.0A)
G39  A 908 (-4.6A)
 1.22A 4cpzA-6eksA:
24.9		 4cpzA-6eksA:
20.31
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4CPZ_A_ZMRA1471_2
(NEURAMINIDASE)		 4b7j NEURAMINIDASE
(Influenza
A
virus) 		5 / 5 LEU A 134
ASP A 151
ARG A 152
ARG A 156
TRP A 179
 None
G39  A1470 (-3.7A)
G39  A1470 (-3.9A)
None
None
 0.19A 4cpzA-4b7jA:
52.9		 4cpzA-4b7jA:
33.95
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4CPZ_A_ZMRA1471_2
(NEURAMINIDASE)		 4hzz NEURAMINIDASE
(Influenza
A
virus) 		5 / 5 LEU A 134
ASP A 151
ARG A 152
ARG A 156
TRP A 178
 None
G39  A 509 (-3.6A)
G39  A 509 (-3.9A)
None
None
 0.14A 4cpzA-4hzzA:
52.3		 4cpzA-4hzzA:
30.42
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4CPZ_B_ZMRB1471_1
(NEURAMINIDASE)		 4b7j NEURAMINIDASE
(Influenza
A
virus) 		9 / 12 ARG A 118
GLU A 119
ARG A 225
GLU A 228
GLU A 277
GLU A 278
ARG A 293
ASN A 295
TYR A 402
 G39  A1470 (-3.1A)
G39  A1470 (-3.5A)
G39  A1470 (-4.4A)
None
G39  A1470 (-3.7A)
G39  A1470 (-4.2A)
G39  A1470 (-2.9A)
G39  A1470 ( 3.7A)
G39  A1470 (-4.5A)
 0.67A 4cpzB-4b7jA:
52.8		 4cpzB-4b7jA:
33.95
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4CPZ_B_ZMRB1471_1
(NEURAMINIDASE)		 4b7j NEURAMINIDASE
(Influenza
A
virus) 		9 / 12 ARG A 118
GLU A 119
ARG A 225
GLU A 228
GLU A 278
ARG A 293
ASN A 295
ARG A 368
TYR A 402
 G39  A1470 (-3.1A)
G39  A1470 (-3.5A)
G39  A1470 (-4.4A)
None
G39  A1470 (-4.2A)
G39  A1470 (-2.9A)
G39  A1470 ( 3.7A)
G39  A1470 (-3.0A)
G39  A1470 (-4.5A)
 0.48A 4cpzB-4b7jA:
52.8		 4cpzB-4b7jA:
33.95
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4CPZ_B_ZMRB1471_1
(NEURAMINIDASE)		 4hzz NEURAMINIDASE
(Influenza
A
virus) 		8 / 12 ARG A 118
GLU A 119
ARG A 224
GLU A 227
ALA A 246
GLU A 276
GLU A 277
TYR A 406
 G39  A 509 (-3.0A)
G39  A 509 (-3.3A)
G39  A 509 (-4.7A)
None
G39  A 509 ( 4.1A)
G39  A 509 ( 4.1A)
G39  A 509 ( 4.0A)
G39  A 509 (-4.6A)
 0.66A 4cpzB-4hzzA:
52.1		 4cpzB-4hzzA:
30.42
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4CPZ_B_ZMRB1471_1
(NEURAMINIDASE)		 4hzz NEURAMINIDASE
(Influenza
A
virus) 		9 / 12 ARG A 118
GLU A 119
ARG A 224
GLU A 227
ALA A 246
GLU A 277
ARG A 292
ARG A 371
TYR A 406
 G39  A 509 (-3.0A)
G39  A 509 (-3.3A)
G39  A 509 (-4.7A)
None
G39  A 509 ( 4.1A)
G39  A 509 ( 4.0A)
G39  A 509 (-2.8A)
G39  A 509 (-2.9A)
G39  A 509 (-4.6A)
 0.51A 4cpzB-4hzzA:
52.1		 4cpzB-4hzzA:
30.42
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4CPZ_B_ZMRB1471_1
(NEURAMINIDASE)		 4hzz NEURAMINIDASE
(Influenza
A
virus) 		8 / 12 GLU A 119
ARG A 224
GLU A 227
ALA A 246
GLU A 276
GLU A 277
ASN A 294
TYR A 406
 G39  A 509 (-3.3A)
G39  A 509 (-4.7A)
None
G39  A 509 ( 4.1A)
G39  A 509 ( 4.1A)
G39  A 509 ( 4.0A)
G39  A 509 ( 4.4A)
G39  A 509 (-4.6A)
 1.00A 4cpzB-4hzzA:
52.1		 4cpzB-4hzzA:
30.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CPZ_B_ZMRB1471_1
(NEURAMINIDASE)		 4yw5 NEURAMINIDASE C
(Streptococcus
pneumoniae) 		5 / 12 ARG A 290
GLU A 584
ARG A 600
ARG A 662
TYR A 695
 G39  A 801 (-2.6A)
G39  A 801 ( 4.7A)
G39  A 801 (-2.9A)
G39  A 801 (-2.9A)
G39  A 801 (-4.4A)
 0.41A 4cpzB-4yw5A:
23.9		 4cpzB-4yw5A:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CPZ_B_ZMRB1471_1
(NEURAMINIDASE)		 6eks SIALIDASE
(Vibrio
cholerae) 		5 / 12 ARG A 250
GLU A 645
ARG A 661
ARG A 738
TYR A 766
 G39  A 908 (-2.8A)
G39  A 908 (-4.0A)
G39  A 908 (-2.8A)
G39  A 908 (-3.0A)
G39  A 908 (-4.6A)
 0.31A 4cpzB-6eksA:
6.7		 4cpzB-6eksA:
20.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CPZ_B_ZMRB1471_1
(NEURAMINIDASE)		 6eks SIALIDASE
(Vibrio
cholerae) 		5 / 12 ARG A 250
LEU A 606
GLU A 645
ARG A 738
TYR A 766
 G39  A 908 (-2.8A)
None
G39  A 908 (-4.0A)
G39  A 908 (-3.0A)
G39  A 908 (-4.6A)
 1.25A 4cpzB-6eksA:
6.7		 4cpzB-6eksA:
20.31
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4CPZ_B_ZMRB1471_2
(NEURAMINIDASE)		 4b7j NEURAMINIDASE
(Influenza
A
virus) 		4 / 4 ASP A 151
ARG A 152
ARG A 156
TRP A 179
 G39  A1470 (-3.7A)
G39  A1470 (-3.9A)
None
None
 0.19A 4cpzB-4b7jA:
52.8		 4cpzB-4b7jA:
33.95
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4CPZ_B_ZMRB1471_2
(NEURAMINIDASE)		 4hzz NEURAMINIDASE
(Influenza
A
virus) 		4 / 4 ASP A 151
ARG A 152
ARG A 156
TRP A 178
 G39  A 509 (-3.6A)
G39  A 509 (-3.9A)
None
None
 0.19A 4cpzB-4hzzA:
52.1		 4cpzB-4hzzA:
30.42
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4CPZ_C_ZMRC1470_1
(NEURAMINIDASE)		 4b7j NEURAMINIDASE
(Influenza
A
virus) 		11 / 12 ARG A 118
GLU A 119
ASP A 151
ARG A 225
GLU A 228
GLU A 277
GLU A 278
ARG A 293
ASN A 295
ARG A 368
TYR A 402
 G39  A1470 (-3.1A)
G39  A1470 (-3.5A)
G39  A1470 (-3.7A)
G39  A1470 (-4.4A)
None
G39  A1470 (-3.7A)
G39  A1470 (-4.2A)
G39  A1470 (-2.9A)
G39  A1470 ( 3.7A)
G39  A1470 (-3.0A)
G39  A1470 (-4.5A)
 0.61A 4cpzC-4b7jA:
52.9		 4cpzC-4b7jA:
33.95
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4CPZ_C_ZMRC1470_1
(NEURAMINIDASE)		 4hzz NEURAMINIDASE
(Influenza
A
virus) 		8 / 12 ARG A 118
GLU A 119
ASP A 151
ARG A 224
GLU A 227
ALA A 246
GLU A 276
GLU A 277
 G39  A 509 (-3.0A)
G39  A 509 (-3.3A)
G39  A 509 (-3.6A)
G39  A 509 (-4.7A)
None
G39  A 509 ( 4.1A)
G39  A 509 ( 4.1A)
G39  A 509 ( 4.0A)
 0.64A 4cpzC-4hzzA:
52.2		 4cpzC-4hzzA:
30.42
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4CPZ_C_ZMRC1470_1
(NEURAMINIDASE)		 4hzz NEURAMINIDASE
(Influenza
A
virus) 		10 / 12 ARG A 118
GLU A 119
ASP A 151
ARG A 224
GLU A 227
ALA A 246
GLU A 277
ARG A 292
ARG A 371
TYR A 406
 G39  A 509 (-3.0A)
G39  A 509 (-3.3A)
G39  A 509 (-3.6A)
G39  A 509 (-4.7A)
None
G39  A 509 ( 4.1A)
G39  A 509 ( 4.0A)
G39  A 509 (-2.8A)
G39  A 509 (-2.9A)
G39  A 509 (-4.6A)
 0.48A 4cpzC-4hzzA:
52.2		 4cpzC-4hzzA:
30.42
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4CPZ_C_ZMRC1470_1
(NEURAMINIDASE)		 4hzz NEURAMINIDASE
(Influenza
A
virus) 		5 / 12 ARG A 371
ARG A 224
ALA A 246
GLU A 276
GLU A 277
 G39  A 509 (-2.9A)
G39  A 509 (-4.7A)
G39  A 509 ( 4.1A)
G39  A 509 ( 4.1A)
G39  A 509 ( 4.0A)
 1.29A 4cpzC-4hzzA:
52.2		 4cpzC-4hzzA:
30.42
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4CPZ_C_ZMRC1470_1
(NEURAMINIDASE)		 4hzz NEURAMINIDASE
(Influenza
A
virus) 		7 / 12 GLU A 119
ARG A 224
GLU A 227
ALA A 246
GLU A 276
GLU A 277
ASN A 294
 G39  A 509 (-3.3A)
G39  A 509 (-4.7A)
None
G39  A 509 ( 4.1A)
G39  A 509 ( 4.1A)
G39  A 509 ( 4.0A)
G39  A 509 ( 4.4A)
 1.04A 4cpzC-4hzzA:
52.2		 4cpzC-4hzzA:
30.42
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4CPZ_C_ZMRC1470_1
(NEURAMINIDASE)		 4hzz NEURAMINIDASE
(Influenza
A
virus) 		7 / 12 GLU A 119
ARG A 224
GLU A 227
ALA A 246
GLU A 277
ASN A 294
TYR A 406
 G39  A 509 (-3.3A)
G39  A 509 (-4.7A)
None
G39  A 509 ( 4.1A)
G39  A 509 ( 4.0A)
G39  A 509 ( 4.4A)
G39  A 509 (-4.6A)
 0.92A 4cpzC-4hzzA:
52.2		 4cpzC-4hzzA:
30.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CPZ_C_ZMRC1470_1
(NEURAMINIDASE)		 4yw5 NEURAMINIDASE C
(Streptococcus
pneumoniae) 		6 / 12 ARG A 290
ASP A 315
GLU A 584
ARG A 600
ARG A 662
TYR A 695
 G39  A 801 (-2.6A)
G39  A 801 (-3.2A)
G39  A 801 ( 4.7A)
G39  A 801 (-2.9A)
G39  A 801 (-2.9A)
G39  A 801 (-4.4A)
 0.79A 4cpzC-4yw5A:
7.3		 4cpzC-4yw5A:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CPZ_C_ZMRC1470_1
(NEURAMINIDASE)		 6eks SIALIDASE
(Vibrio
cholerae) 		6 / 12 ARG A 250
ASP A 276
GLU A 645
ARG A 661
ARG A 738
TYR A 766
 G39  A 908 (-2.8A)
G39  A 908 (-3.3A)
G39  A 908 (-4.0A)
G39  A 908 (-2.8A)
G39  A 908 (-3.0A)
G39  A 908 (-4.6A)
 0.49A 4cpzC-6eksA:
13.7		 4cpzC-6eksA:
20.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CPZ_C_ZMRC1470_1
(NEURAMINIDASE)		 6eks SIALIDASE
(Vibrio
cholerae) 		5 / 12 ARG A 738
GLU A 782
GLU A 269
ARG A 661
TYR A 766
 G39  A 908 (-3.0A)
None
G39  A 908 ( 4.7A)
G39  A 908 (-2.8A)
G39  A 908 (-4.6A)
 1.48A 4cpzC-6eksA:
13.7		 4cpzC-6eksA:
20.31
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4CPZ_C_ZMRC1470_2
(NEURAMINIDASE)		 4b7j NEURAMINIDASE
(Influenza
A
virus) 		3 / 3 ARG A 152
ARG A 156
TRP A 179
 G39  A1470 (-3.9A)
None
None
 0.18A 4cpzC-4b7jA:
52.9		 4cpzC-4b7jA:
33.95
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4CPZ_C_ZMRC1470_2
(NEURAMINIDASE)		 4hzz NEURAMINIDASE
(Influenza
A
virus) 		3 / 3 ARG A 152
ARG A 156
TRP A 178
 G39  A 509 (-3.9A)
None
None
 0.16A 4cpzC-4hzzA:
52.2		 4cpzC-4hzzA:
30.42
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4CPZ_D_ZMRD1471_1
(NEURAMINIDASE)		 4b7j NEURAMINIDASE
(Influenza
A
virus) 		8 / 12 ARG A 118
GLU A 119
ARG A 225
GLU A 228
GLU A 277
GLU A 278
ASN A 295
TYR A 402
 G39  A1470 (-3.1A)
G39  A1470 (-3.5A)
G39  A1470 (-4.4A)
None
G39  A1470 (-3.7A)
G39  A1470 (-4.2A)
G39  A1470 ( 3.7A)
G39  A1470 (-4.5A)
 0.71A 4cpzD-4b7jA:
52.7		 4cpzD-4b7jA:
33.95
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4CPZ_D_ZMRD1471_1
(NEURAMINIDASE)		 4b7j NEURAMINIDASE
(Influenza
A
virus) 		9 / 12 ARG A 118
GLU A 119
ARG A 225
GLU A 228
GLU A 278
ARG A 293
ASN A 295
ARG A 368
TYR A 402
 G39  A1470 (-3.1A)
G39  A1470 (-3.5A)
G39  A1470 (-4.4A)
None
G39  A1470 (-4.2A)
G39  A1470 (-2.9A)
G39  A1470 ( 3.7A)
G39  A1470 (-3.0A)
G39  A1470 (-4.5A)
 0.51A 4cpzD-4b7jA:
52.7		 4cpzD-4b7jA:
33.95
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4CPZ_D_ZMRD1471_1
(NEURAMINIDASE)		 4hzz NEURAMINIDASE
(Influenza
A
virus) 		8 / 12 ARG A 118
GLU A 119
ARG A 224
GLU A 227
ALA A 246
GLU A 276
GLU A 277
TYR A 406
 G39  A 509 (-3.0A)
G39  A 509 (-3.3A)
G39  A 509 (-4.7A)
None
G39  A 509 ( 4.1A)
G39  A 509 ( 4.1A)
G39  A 509 ( 4.0A)
G39  A 509 (-4.6A)
 0.67A 4cpzD-4hzzA:
52.1		 4cpzD-4hzzA:
30.42
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4CPZ_D_ZMRD1471_1
(NEURAMINIDASE)		 4hzz NEURAMINIDASE
(Influenza
A
virus) 		9 / 12 ARG A 118
GLU A 119
ARG A 224
GLU A 227
ALA A 246
GLU A 277
ARG A 292
ARG A 371
TYR A 406
 G39  A 509 (-3.0A)
G39  A 509 (-3.3A)
G39  A 509 (-4.7A)
None
G39  A 509 ( 4.1A)
G39  A 509 ( 4.0A)
G39  A 509 (-2.8A)
G39  A 509 (-2.9A)
G39  A 509 (-4.6A)
 0.49A 4cpzD-4hzzA:
52.1		 4cpzD-4hzzA:
30.42
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4CPZ_D_ZMRD1471_1
(NEURAMINIDASE)		 4hzz NEURAMINIDASE
(Influenza
A
virus) 		8 / 12 GLU A 119
ARG A 224
GLU A 227
ALA A 246
GLU A 276
GLU A 277
ASN A 294
TYR A 406
 G39  A 509 (-3.3A)
G39  A 509 (-4.7A)
None
G39  A 509 ( 4.1A)
G39  A 509 ( 4.1A)
G39  A 509 ( 4.0A)
G39  A 509 ( 4.4A)
G39  A 509 (-4.6A)
 1.00A 4cpzD-4hzzA:
52.1		 4cpzD-4hzzA:
30.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CPZ_D_ZMRD1471_1
(NEURAMINIDASE)		 4yw5 NEURAMINIDASE C
(Streptococcus
pneumoniae) 		5 / 12 ARG A 290
GLU A 584
ARG A 600
ARG A 662
TYR A 695
 G39  A 801 (-2.6A)
G39  A 801 ( 4.7A)
G39  A 801 (-2.9A)
G39  A 801 (-2.9A)
G39  A 801 (-4.4A)
 0.35A 4cpzD-4yw5A:
24.0		 4cpzD-4yw5A:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CPZ_D_ZMRD1471_1
(NEURAMINIDASE)		 6eks SIALIDASE
(Vibrio
cholerae) 		5 / 12 ARG A 250
GLU A 645
ARG A 661
ARG A 738
TYR A 766
 G39  A 908 (-2.8A)
G39  A 908 (-4.0A)
G39  A 908 (-2.8A)
G39  A 908 (-3.0A)
G39  A 908 (-4.6A)
 0.34A 4cpzD-6eksA:
13.8		 4cpzD-6eksA:
20.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CPZ_D_ZMRD1471_1
(NEURAMINIDASE)		 6eks SIALIDASE
(Vibrio
cholerae) 		5 / 12 ARG A 250
LEU A 606
GLU A 645
ARG A 738
TYR A 766
 G39  A 908 (-2.8A)
None
G39  A 908 (-4.0A)
G39  A 908 (-3.0A)
G39  A 908 (-4.6A)
 1.24A 4cpzD-6eksA:
13.8		 4cpzD-6eksA:
20.31
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4CPZ_D_ZMRD1471_2
(NEURAMINIDASE)		 4b7j NEURAMINIDASE
(Influenza
A
virus) 		4 / 4 ASP A 151
ARG A 152
ARG A 156
TRP A 179
 G39  A1470 (-3.7A)
G39  A1470 (-3.9A)
None
None
 0.16A 4cpzD-4b7jA:
52.7		 4cpzD-4b7jA:
33.95
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4CPZ_D_ZMRD1471_2
(NEURAMINIDASE)		 4hzz NEURAMINIDASE
(Influenza
A
virus) 		4 / 4 ASP A 151
ARG A 152
ARG A 156
TRP A 178
 G39  A 509 (-3.6A)
G39  A 509 (-3.9A)
None
None
 0.15A 4cpzD-4hzzA:
52.0		 4cpzD-4hzzA:
30.42
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4CPZ_E_ZMRE1471_1
(NEURAMINIDASE)		 4b7j NEURAMINIDASE
(Influenza
A
virus) 		8 / 12 ARG A 118
GLU A 119
ASP A 151
ARG A 225
GLU A 228
GLU A 277
GLU A 278
TYR A 402
 G39  A1470 (-3.1A)
G39  A1470 (-3.5A)
G39  A1470 (-3.7A)
G39  A1470 (-4.4A)
None
G39  A1470 (-3.7A)
G39  A1470 (-4.2A)
G39  A1470 (-4.5A)
 0.72A 4cpzE-4b7jA:
52.7		 4cpzE-4b7jA:
33.95
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4CPZ_E_ZMRE1471_1
(NEURAMINIDASE)		 4b7j NEURAMINIDASE
(Influenza
A
virus) 		9 / 12 ARG A 118
GLU A 119
ASP A 151
ARG A 225
GLU A 228
GLU A 278
ARG A 293
ARG A 368
TYR A 402
 G39  A1470 (-3.1A)
G39  A1470 (-3.5A)
G39  A1470 (-3.7A)
G39  A1470 (-4.4A)
None
G39  A1470 (-4.2A)
G39  A1470 (-2.9A)
G39  A1470 (-3.0A)
G39  A1470 (-4.5A)
 0.50A 4cpzE-4b7jA:
52.7		 4cpzE-4b7jA:
33.95
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4CPZ_E_ZMRE1471_1
(NEURAMINIDASE)		 4hzz NEURAMINIDASE
(Influenza
A
virus) 		10 / 12 ARG A 118
GLU A 119
ASP A 151
ARG A 224
GLU A 227
ALA A 246
GLU A 277
ARG A 292
ARG A 371
TYR A 406
 G39  A 509 (-3.0A)
G39  A 509 (-3.3A)
G39  A 509 (-3.6A)
G39  A 509 (-4.7A)
None
G39  A 509 ( 4.1A)
G39  A 509 ( 4.0A)
G39  A 509 (-2.8A)
G39  A 509 (-2.9A)
G39  A 509 (-4.6A)
 0.55A 4cpzE-4hzzA:
52.1		 4cpzE-4hzzA:
30.42
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4CPZ_E_ZMRE1471_1
(NEURAMINIDASE)		 4hzz NEURAMINIDASE
(Influenza
A
virus) 		5 / 12 ARG A 371
ARG A 224
ALA A 246
GLU A 276
GLU A 277
 G39  A 509 (-2.9A)
G39  A 509 (-4.7A)
G39  A 509 ( 4.1A)
G39  A 509 ( 4.1A)
G39  A 509 ( 4.0A)
 1.29A 4cpzE-4hzzA:
52.1		 4cpzE-4hzzA:
30.42
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4CPZ_E_ZMRE1471_1
(NEURAMINIDASE)		 4hzz NEURAMINIDASE
(Influenza
A
virus) 		7 / 12 GLU A 119
ASP A 151
ARG A 224
GLU A 227
ALA A 246
GLU A 276
GLU A 277
 G39  A 509 (-3.3A)
G39  A 509 (-3.6A)
G39  A 509 (-4.7A)
None
G39  A 509 ( 4.1A)
G39  A 509 ( 4.1A)
G39  A 509 ( 4.0A)
 0.72A 4cpzE-4hzzA:
52.1		 4cpzE-4hzzA:
30.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CPZ_E_ZMRE1471_1
(NEURAMINIDASE)		 4yw5 NEURAMINIDASE C
(Streptococcus
pneumoniae) 		6 / 12 ARG A 290
ASP A 315
GLU A 584
ARG A 600
ARG A 662
TYR A 695
 G39  A 801 (-2.6A)
G39  A 801 (-3.2A)
G39  A 801 ( 4.7A)
G39  A 801 (-2.9A)
G39  A 801 (-2.9A)
G39  A 801 (-4.4A)
 0.81A 4cpzE-4yw5A:
8.3		 4cpzE-4yw5A:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CPZ_E_ZMRE1471_1
(NEURAMINIDASE)		 6eks SIALIDASE
(Vibrio
cholerae) 		6 / 12 ARG A 250
ASP A 276
GLU A 645
ARG A 661
ARG A 738
TYR A 766
 G39  A 908 (-2.8A)
G39  A 908 (-3.3A)
G39  A 908 (-4.0A)
G39  A 908 (-2.8A)
G39  A 908 (-3.0A)
G39  A 908 (-4.6A)
 0.56A 4cpzE-6eksA:
13.8		 4cpzE-6eksA:
20.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CPZ_E_ZMRE1471_1
(NEURAMINIDASE)		 6eks SIALIDASE
(Vibrio
cholerae) 		5 / 12 ARG A 250
LEU A 606
GLU A 645
ARG A 738
TYR A 766
 G39  A 908 (-2.8A)
None
G39  A 908 (-4.0A)
G39  A 908 (-3.0A)
G39  A 908 (-4.6A)
 1.24A 4cpzE-6eksA:
13.8		 4cpzE-6eksA:
20.31
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4CPZ_E_ZMRE1471_2
(NEURAMINIDASE)		 4b7j NEURAMINIDASE
(Influenza
A
virus) 		3 / 3 ARG A 152
ARG A 156
TRP A 179
 G39  A1470 (-3.9A)
None
None
 0.12A 4cpzE-4b7jA:
52.7		 4cpzE-4b7jA:
33.95
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4CPZ_E_ZMRE1471_2
(NEURAMINIDASE)		 4hzz NEURAMINIDASE
(Influenza
A
virus) 		3 / 3 ARG A 152
ARG A 156
TRP A 178
 G39  A 509 (-3.9A)
None
None
 0.16A 4cpzE-4hzzA:
52.1		 4cpzE-4hzzA:
30.42
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4CPZ_F_ZMRF1470_1
(NEURAMINIDASE)		 4b7j NEURAMINIDASE
(Influenza
A
virus) 		9 / 12 ARG A 118
GLU A 119
ASP A 151
ARG A 225
GLU A 228
GLU A 277
GLU A 278
ASN A 295
TYR A 402
 G39  A1470 (-3.1A)
G39  A1470 (-3.5A)
G39  A1470 (-3.7A)
G39  A1470 (-4.4A)
None
G39  A1470 (-3.7A)
G39  A1470 (-4.2A)
G39  A1470 ( 3.7A)
G39  A1470 (-4.5A)
 0.73A 4cpzF-4b7jA:
52.8		 4cpzF-4b7jA:
33.95
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4CPZ_F_ZMRF1470_1
(NEURAMINIDASE)		 4b7j NEURAMINIDASE
(Influenza
A
virus) 		10 / 12 ARG A 118
GLU A 119
ASP A 151
ARG A 225
GLU A 228
GLU A 278
ARG A 293
ASN A 295
ARG A 368
TYR A 402
 G39  A1470 (-3.1A)
G39  A1470 (-3.5A)
G39  A1470 (-3.7A)
G39  A1470 (-4.4A)
None
G39  A1470 (-4.2A)
G39  A1470 (-2.9A)
G39  A1470 ( 3.7A)
G39  A1470 (-3.0A)
G39  A1470 (-4.5A)
 0.50A 4cpzF-4b7jA:
52.8		 4cpzF-4b7jA:
33.95
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4CPZ_F_ZMRF1470_1
(NEURAMINIDASE)		 4hzz NEURAMINIDASE
(Influenza
A
virus) 		8 / 12 ARG A 118
GLU A 119
ASP A 151
ARG A 224
GLU A 227
ALA A 246
GLU A 276
GLU A 277
 G39  A 509 (-3.0A)
G39  A 509 (-3.3A)
G39  A 509 (-3.6A)
G39  A 509 (-4.7A)
None
G39  A 509 ( 4.1A)
G39  A 509 ( 4.1A)
G39  A 509 ( 4.0A)
 0.71A 4cpzF-4hzzA:
52.0		 4cpzF-4hzzA:
30.42
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4CPZ_F_ZMRF1470_1
(NEURAMINIDASE)		 4hzz NEURAMINIDASE
(Influenza
A
virus) 		10 / 12 ARG A 118
GLU A 119
ASP A 151
ARG A 224
GLU A 227
ALA A 246
GLU A 277
ARG A 292
ARG A 371
TYR A 406
 G39  A 509 (-3.0A)
G39  A 509 (-3.3A)
G39  A 509 (-3.6A)
G39  A 509 (-4.7A)
None
G39  A 509 ( 4.1A)
G39  A 509 ( 4.0A)
G39  A 509 (-2.8A)
G39  A 509 (-2.9A)
G39  A 509 (-4.6A)
 0.52A 4cpzF-4hzzA:
52.0		 4cpzF-4hzzA:
30.42
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4CPZ_F_ZMRF1470_1
(NEURAMINIDASE)		 4hzz NEURAMINIDASE
(Influenza
A
virus) 		5 / 12 ARG A 371
ARG A 224
ALA A 246
GLU A 276
GLU A 277
 G39  A 509 (-2.9A)
G39  A 509 (-4.7A)
G39  A 509 ( 4.1A)
G39  A 509 ( 4.1A)
G39  A 509 ( 4.0A)
 1.31A 4cpzF-4hzzA:
52.0		 4cpzF-4hzzA:
30.42
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4CPZ_F_ZMRF1470_1
(NEURAMINIDASE)		 4hzz NEURAMINIDASE
(Influenza
A
virus) 		6 / 12 GLU A 119
ARG A 224
GLU A 227
GLU A 276
GLU A 277
ASN A 294
 G39  A 509 (-3.3A)
G39  A 509 (-4.7A)
None
G39  A 509 ( 4.1A)
G39  A 509 ( 4.0A)
G39  A 509 ( 4.4A)
 1.14A 4cpzF-4hzzA:
52.0		 4cpzF-4hzzA:
30.42
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4CPZ_F_ZMRF1470_1
(NEURAMINIDASE)		 4hzz NEURAMINIDASE
(Influenza
A
virus) 		7 / 12 GLU A 119
ARG A 224
GLU A 227
GLU A 277
ARG A 292
ASN A 294
TYR A 406
 G39  A 509 (-3.3A)
G39  A 509 (-4.7A)
None
G39  A 509 ( 4.0A)
G39  A 509 (-2.8A)
G39  A 509 ( 4.4A)
G39  A 509 (-4.6A)
 0.95A 4cpzF-4hzzA:
52.0		 4cpzF-4hzzA:
30.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CPZ_F_ZMRF1470_1
(NEURAMINIDASE)		 4yw5 NEURAMINIDASE C
(Streptococcus
pneumoniae) 		6 / 12 ARG A 290
ASP A 315
GLU A 584
ARG A 600
ARG A 662
TYR A 695
 G39  A 801 (-2.6A)
G39  A 801 (-3.2A)
G39  A 801 ( 4.7A)
G39  A 801 (-2.9A)
G39  A 801 (-2.9A)
G39  A 801 (-4.4A)
 0.84A 4cpzF-4yw5A:
7.1		 4cpzF-4yw5A:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CPZ_F_ZMRF1470_1
(NEURAMINIDASE)		 6eks SIALIDASE
(Vibrio
cholerae) 		6 / 12 ARG A 250
ASP A 276
GLU A 645
ARG A 661
ARG A 738
TYR A 766
 G39  A 908 (-2.8A)
G39  A 908 (-3.3A)
G39  A 908 (-4.0A)
G39  A 908 (-2.8A)
G39  A 908 (-3.0A)
G39  A 908 (-4.6A)
 0.55A 4cpzF-6eksA:
25.0		 4cpzF-6eksA:
20.31
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4CPZ_F_ZMRF1470_2
(NEURAMINIDASE)		 4b7j NEURAMINIDASE
(Influenza
A
virus) 		3 / 3 ARG A 152
ARG A 156
TRP A 179
 G39  A1470 (-3.9A)
None
None
 0.16A 4cpzF-4b7jA:
52.8		 4cpzF-4b7jA:
33.95
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4CPZ_F_ZMRF1470_2
(NEURAMINIDASE)		 4hzz NEURAMINIDASE
(Influenza
A
virus) 		3 / 3 ARG A 152
ARG A 156
TRP A 178
 G39  A 509 (-3.9A)
None
None
 0.09A 4cpzF-4hzzA:
52.0		 4cpzF-4hzzA:
30.42
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4CPZ_G_ZMRG1471_1
(NEURAMINIDASE)		 4b7j NEURAMINIDASE
(Influenza
A
virus) 		9 / 12 ARG A 118
GLU A 119
ASP A 151
ARG A 225
GLU A 228
GLU A 277
GLU A 278
ASN A 295
TYR A 402
 G39  A1470 (-3.1A)
G39  A1470 (-3.5A)
G39  A1470 (-3.7A)
G39  A1470 (-4.4A)
None
G39  A1470 (-3.7A)
G39  A1470 (-4.2A)
G39  A1470 ( 3.7A)
G39  A1470 (-4.5A)
 0.68A 4cpzG-4b7jA:
52.5		 4cpzG-4b7jA:
33.95
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4CPZ_G_ZMRG1471_1
(NEURAMINIDASE)		 4b7j NEURAMINIDASE
(Influenza
A
virus) 		10 / 12 ARG A 118
GLU A 119
ASP A 151
ARG A 225
GLU A 228
GLU A 278
ARG A 293
ASN A 295
ARG A 368
TYR A 402
 G39  A1470 (-3.1A)
G39  A1470 (-3.5A)
G39  A1470 (-3.7A)
G39  A1470 (-4.4A)
None
G39  A1470 (-4.2A)
G39  A1470 (-2.9A)
G39  A1470 ( 3.7A)
G39  A1470 (-3.0A)
G39  A1470 (-4.5A)
 0.44A 4cpzG-4b7jA:
52.5		 4cpzG-4b7jA:
33.95
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4CPZ_G_ZMRG1471_1
(NEURAMINIDASE)		 4hzz NEURAMINIDASE
(Influenza
A
virus) 		8 / 12 ARG A 118
GLU A 119
ASP A 151
ARG A 224
GLU A 227
ALA A 246
GLU A 276
GLU A 277
 G39  A 509 (-3.0A)
G39  A 509 (-3.3A)
G39  A 509 (-3.6A)
G39  A 509 (-4.7A)
None
G39  A 509 ( 4.1A)
G39  A 509 ( 4.1A)
G39  A 509 ( 4.0A)
 0.69A 4cpzG-4hzzA:
52.0		 4cpzG-4hzzA:
30.42
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4CPZ_G_ZMRG1471_1
(NEURAMINIDASE)		 4hzz NEURAMINIDASE
(Influenza
A
virus) 		10 / 12 ARG A 118
GLU A 119
ASP A 151
ARG A 224
GLU A 227
ALA A 246
GLU A 277
ARG A 292
ARG A 371
TYR A 406
 G39  A 509 (-3.0A)
G39  A 509 (-3.3A)
G39  A 509 (-3.6A)
G39  A 509 (-4.7A)
None
G39  A 509 ( 4.1A)
G39  A 509 ( 4.0A)
G39  A 509 (-2.8A)
G39  A 509 (-2.9A)
G39  A 509 (-4.6A)
 0.46A 4cpzG-4hzzA:
52.0		 4cpzG-4hzzA:
30.42
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4CPZ_G_ZMRG1471_1
(NEURAMINIDASE)		 4hzz NEURAMINIDASE
(Influenza
A
virus) 		5 / 12 ARG A 371
ARG A 224
ALA A 246
GLU A 276
GLU A 277
 G39  A 509 (-2.9A)
G39  A 509 (-4.7A)
G39  A 509 ( 4.1A)
G39  A 509 ( 4.1A)
G39  A 509 ( 4.0A)
 1.37A 4cpzG-4hzzA:
52.0		 4cpzG-4hzzA:
30.42
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4CPZ_G_ZMRG1471_1
(NEURAMINIDASE)		 4hzz NEURAMINIDASE
(Influenza
A
virus) 		7 / 12 GLU A 119
ARG A 224
GLU A 227
ALA A 246
GLU A 276
GLU A 277
ASN A 294
 G39  A 509 (-3.3A)
G39  A 509 (-4.7A)
None
G39  A 509 ( 4.1A)
G39  A 509 ( 4.1A)
G39  A 509 ( 4.0A)
G39  A 509 ( 4.4A)
 1.06A 4cpzG-4hzzA:
52.0		 4cpzG-4hzzA:
30.42
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4CPZ_G_ZMRG1471_1
(NEURAMINIDASE)		 4hzz NEURAMINIDASE
(Influenza
A
virus) 		7 / 12 GLU A 119
ARG A 224
GLU A 227
ALA A 246
GLU A 277
ASN A 294
TYR A 406
 G39  A 509 (-3.3A)
G39  A 509 (-4.7A)
None
G39  A 509 ( 4.1A)
G39  A 509 ( 4.0A)
G39  A 509 ( 4.4A)
G39  A 509 (-4.6A)
 0.89A 4cpzG-4hzzA:
52.0		 4cpzG-4hzzA:
30.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CPZ_G_ZMRG1471_1
(NEURAMINIDASE)		 4yw5 NEURAMINIDASE C
(Streptococcus
pneumoniae) 		6 / 12 ARG A 290
ASP A 315
GLU A 584
ARG A 600
ARG A 662
TYR A 695
 G39  A 801 (-2.6A)
G39  A 801 (-3.2A)
G39  A 801 ( 4.7A)
G39  A 801 (-2.9A)
G39  A 801 (-2.9A)
G39  A 801 (-4.4A)
 0.74A 4cpzG-4yw5A:
23.9		 4cpzG-4yw5A:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CPZ_G_ZMRG1471_1
(NEURAMINIDASE)		 6eks SIALIDASE
(Vibrio
cholerae) 		6 / 12 ARG A 250
ASP A 276
GLU A 645
ARG A 661
ARG A 738
TYR A 766
 G39  A 908 (-2.8A)
G39  A 908 (-3.3A)
G39  A 908 (-4.0A)
G39  A 908 (-2.8A)
G39  A 908 (-3.0A)
G39  A 908 (-4.6A)
 0.46A 4cpzG-6eksA:
13.8		 4cpzG-6eksA:
20.31
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4CPZ_G_ZMRG1471_2
(NEURAMINIDASE)		 4b7j NEURAMINIDASE
(Influenza
A
virus) 		3 / 3 ARG A 152
ARG A 156
TRP A 179
 G39  A1470 (-3.9A)
None
None
 0.18A 4cpzG-4b7jA:
52.5		 4cpzG-4b7jA:
33.95
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4CPZ_G_ZMRG1471_2
(NEURAMINIDASE)		 4hzz NEURAMINIDASE
(Influenza
A
virus) 		3 / 3 ARG A 152
ARG A 156
TRP A 178
 G39  A 509 (-3.9A)
None
None
 0.12A 4cpzG-4hzzA:
52.0		 4cpzG-4hzzA:
30.42
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4CPZ_H_ZMRH1470_1
(NEURAMINIDASE)		 4b7j NEURAMINIDASE
(Influenza
A
virus) 		9 / 12 ARG A 118
GLU A 119
ASP A 151
ARG A 225
GLU A 228
GLU A 277
GLU A 278
ASN A 295
TYR A 402
 G39  A1470 (-3.1A)
G39  A1470 (-3.5A)
G39  A1470 (-3.7A)
G39  A1470 (-4.4A)
None
G39  A1470 (-3.7A)
G39  A1470 (-4.2A)
G39  A1470 ( 3.7A)
G39  A1470 (-4.5A)
 0.76A 4cpzH-4b7jA:
52.7		 4cpzH-4b7jA:
33.95
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4CPZ_H_ZMRH1470_1
(NEURAMINIDASE)		 4b7j NEURAMINIDASE
(Influenza
A
virus) 		10 / 12 ARG A 118
GLU A 119
ASP A 151
ARG A 225
GLU A 228
GLU A 278
ARG A 293
ASN A 295
ARG A 368
TYR A 402
 G39  A1470 (-3.1A)
G39  A1470 (-3.5A)
G39  A1470 (-3.7A)
G39  A1470 (-4.4A)
None
G39  A1470 (-4.2A)
G39  A1470 (-2.9A)
G39  A1470 ( 3.7A)
G39  A1470 (-3.0A)
G39  A1470 (-4.5A)
 0.57A 4cpzH-4b7jA:
52.7		 4cpzH-4b7jA:
33.95
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4CPZ_H_ZMRH1470_1
(NEURAMINIDASE)		 4hzz NEURAMINIDASE
(Influenza
A
virus) 		8 / 12 ARG A 118
GLU A 119
ASP A 151
ARG A 224
GLU A 227
ALA A 246
GLU A 276
GLU A 277
 G39  A 509 (-3.0A)
G39  A 509 (-3.3A)
G39  A 509 (-3.6A)
G39  A 509 (-4.7A)
None
G39  A 509 ( 4.1A)
G39  A 509 ( 4.1A)
G39  A 509 ( 4.0A)
 0.71A 4cpzH-4hzzA:
52.0		 4cpzH-4hzzA:
30.42
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4CPZ_H_ZMRH1470_1
(NEURAMINIDASE)		 4hzz NEURAMINIDASE
(Influenza
A
virus) 		10 / 12 ARG A 118
GLU A 119
ASP A 151
ARG A 224
GLU A 227
ALA A 246
GLU A 277
ARG A 292
ARG A 371
TYR A 406
 G39  A 509 (-3.0A)
G39  A 509 (-3.3A)
G39  A 509 (-3.6A)
G39  A 509 (-4.7A)
None
G39  A 509 ( 4.1A)
G39  A 509 ( 4.0A)
G39  A 509 (-2.8A)
G39  A 509 (-2.9A)
G39  A 509 (-4.6A)
 0.53A 4cpzH-4hzzA:
52.0		 4cpzH-4hzzA:
30.42
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4CPZ_H_ZMRH1470_1
(NEURAMINIDASE)		 4hzz NEURAMINIDASE
(Influenza
A
virus) 		5 / 12 ARG A 371
ARG A 224
ALA A 246
GLU A 276
GLU A 277
 G39  A 509 (-2.9A)
G39  A 509 (-4.7A)
G39  A 509 ( 4.1A)
G39  A 509 ( 4.1A)
G39  A 509 ( 4.0A)
 1.35A 4cpzH-4hzzA:
52.0		 4cpzH-4hzzA:
30.42
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4CPZ_H_ZMRH1470_1
(NEURAMINIDASE)		 4hzz NEURAMINIDASE
(Influenza
A
virus) 		7 / 12 GLU A 119
ARG A 224
GLU A 227
ALA A 246
GLU A 276
GLU A 277
ASN A 294
 G39  A 509 (-3.3A)
G39  A 509 (-4.7A)
None
G39  A 509 ( 4.1A)
G39  A 509 ( 4.1A)
G39  A 509 ( 4.0A)
G39  A 509 ( 4.4A)
 1.09A 4cpzH-4hzzA:
52.0		 4cpzH-4hzzA:
30.42
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4CPZ_H_ZMRH1470_1
(NEURAMINIDASE)		 4hzz NEURAMINIDASE
(Influenza
A
virus) 		7 / 12 GLU A 119
ARG A 224
GLU A 227
ALA A 246
GLU A 277
ASN A 294
TYR A 406
 G39  A 509 (-3.3A)
G39  A 509 (-4.7A)
None
G39  A 509 ( 4.1A)
G39  A 509 ( 4.0A)
G39  A 509 ( 4.4A)
G39  A 509 (-4.6A)
 0.96A 4cpzH-4hzzA:
52.0		 4cpzH-4hzzA:
30.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CPZ_H_ZMRH1470_1
(NEURAMINIDASE)		 4yw5 NEURAMINIDASE C
(Streptococcus
pneumoniae) 		6 / 12 ARG A 290
ASP A 315
GLU A 584
ARG A 600
ARG A 662
TYR A 695
 G39  A 801 (-2.6A)
G39  A 801 (-3.2A)
G39  A 801 ( 4.7A)
G39  A 801 (-2.9A)
G39  A 801 (-2.9A)
G39  A 801 (-4.4A)
 0.81A 4cpzH-4yw5A:
23.8		 4cpzH-4yw5A:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CPZ_H_ZMRH1470_1
(NEURAMINIDASE)		 6eks SIALIDASE
(Vibrio
cholerae) 		6 / 12 ARG A 250
ASP A 276
GLU A 645
ARG A 661
ARG A 738
TYR A 766
 G39  A 908 (-2.8A)
G39  A 908 (-3.3A)
G39  A 908 (-4.0A)
G39  A 908 (-2.8A)
G39  A 908 (-3.0A)
G39  A 908 (-4.6A)
 0.56A 4cpzH-6eksA:
24.9		 4cpzH-6eksA:
20.31
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4CPZ_H_ZMRH1470_2
(NEURAMINIDASE)		 4b7j NEURAMINIDASE
(Influenza
A
virus) 		3 / 3 ARG A 152
ARG A 156
TRP A 179
 G39  A1470 (-3.9A)
None
None
 0.20A 4cpzH-4b7jA:
52.7		 4cpzH-4b7jA:
33.95
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4CPZ_H_ZMRH1470_2
(NEURAMINIDASE)		 4hzz NEURAMINIDASE
(Influenza
A
virus) 		3 / 3 ARG A 152
ARG A 156
TRP A 178
 G39  A 509 (-3.9A)
None
None
 0.16A 4cpzH-4hzzA:
52.0		 4cpzH-4hzzA:
30.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FEW_D_KAND301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 4yw5 NEURAMINIDASE C
(Streptococcus
pneumoniae) 		4 / 8 ASP A 388
ASP A 315
GLU A 584
ASP A 307
 G39  A 801 ( 4.8A)
G39  A 801 (-3.2A)
G39  A 801 ( 4.7A)
None
 1.21A 4fewD-4yw5A:
undetectable		 4fewD-4yw5A:
18.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GKI_A_KANA301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 4yw5 NEURAMINIDASE C
(Streptococcus
pneumoniae) 		4 / 8 ASP A 388
ASP A 315
GLU A 584
ASP A 307
 G39  A 801 ( 4.8A)
G39  A 801 (-3.2A)
G39  A 801 ( 4.7A)
None
 1.22A 4gkiA-4yw5A:
undetectable		 4gkiA-4yw5A:
18.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4I00_A_ZMRA509_1
(NEURAMINIDASE)		 4b7j NEURAMINIDASE
(Influenza
A
virus) 		8 / 12 ARG A 118
ASP A 151
ARG A 152
ARG A 225
GLU A 228
GLU A 277
GLU A 278
TYR A 402
 G39  A1470 (-3.1A)
G39  A1470 (-3.7A)
G39  A1470 (-3.9A)
G39  A1470 (-4.4A)
None
G39  A1470 (-3.7A)
G39  A1470 (-4.2A)
G39  A1470 (-4.5A)
 0.59A 4i00A-4b7jA:
64.0		 4i00A-4b7jA:
40.42
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4I00_A_ZMRA509_1
(NEURAMINIDASE)		 4b7j NEURAMINIDASE
(Influenza
A
virus) 		10 / 12 ARG A 118
GLU A 119
ASP A 151
ARG A 152
ARG A 225
GLU A 228
GLU A 278
ARG A 293
ARG A 368
TYR A 402
 G39  A1470 (-3.1A)
G39  A1470 (-3.5A)
G39  A1470 (-3.7A)
G39  A1470 (-3.9A)
G39  A1470 (-4.4A)
None
G39  A1470 (-4.2A)
G39  A1470 (-2.9A)
G39  A1470 (-3.0A)
G39  A1470 (-4.5A)
 0.42A 4i00A-4b7jA:
64.0		 4i00A-4b7jA:
40.42
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4I00_A_ZMRA509_1
(NEURAMINIDASE)		 4b7j NEURAMINIDASE
(Influenza
A
virus) 		5 / 12 ARG A 223
GLU A 278
ARG A 293
ARG A 368
TYR A 402
 G39  A1470 (-4.0A)
G39  A1470 (-4.2A)
G39  A1470 (-2.9A)
G39  A1470 (-3.0A)
G39  A1470 (-4.5A)
 1.08A 4i00A-4b7jA:
64.0		 4i00A-4b7jA:
40.42
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4I00_A_ZMRA509_1
(NEURAMINIDASE)		 4hzz NEURAMINIDASE
(Influenza
A
virus) 		11 / 12 ARG A 118
GLU A 119
ASP A 151
ARG A 152
ARG A 224
GLU A 227
ALA A 246
GLU A 277
ARG A 292
ARG A 371
TYR A 406
 G39  A 509 (-3.0A)
G39  A 509 (-3.3A)
G39  A 509 (-3.6A)
G39  A 509 (-3.9A)
G39  A 509 (-4.7A)
None
G39  A 509 ( 4.1A)
G39  A 509 ( 4.0A)
G39  A 509 (-2.8A)
G39  A 509 (-2.9A)
G39  A 509 (-4.6A)
 0.45A 4i00A-4hzzA:
75.2		 4i00A-4hzzA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4I00_A_ZMRA509_1
(NEURAMINIDASE)		 4hzz NEURAMINIDASE
(Influenza
A
virus) 		8 / 12 GLU A 119
ASP A 151
ARG A 152
ARG A 224
GLU A 227
ALA A 246
GLU A 276
GLU A 277
 G39  A 509 (-3.3A)
G39  A 509 (-3.6A)
G39  A 509 (-3.9A)
G39  A 509 (-4.7A)
None
G39  A 509 ( 4.1A)
G39  A 509 ( 4.1A)
G39  A 509 ( 4.0A)
 0.72A 4i00A-4hzzA:
75.2		 4i00A-4hzzA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4I00_A_ZMRA509_1
(NEURAMINIDASE)		 4yw5 NEURAMINIDASE C
(Streptococcus
pneumoniae) 		6 / 12 ARG A 290
ASP A 315
GLU A 584
ARG A 600
ARG A 662
TYR A 695
 G39  A 801 (-2.6A)
G39  A 801 (-3.2A)
G39  A 801 ( 4.7A)
G39  A 801 (-2.9A)
G39  A 801 (-2.9A)
G39  A 801 (-4.4A)
 0.74A 4i00A-4yw5A:
20.6		 4i00A-4yw5A:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4I00_A_ZMRA509_1
(NEURAMINIDASE)		 6eks SIALIDASE
(Vibrio
cholerae) 		6 / 12 ARG A 250
ASP A 276
GLU A 645
ARG A 661
ARG A 738
TYR A 766
 G39  A 908 (-2.8A)
G39  A 908 (-3.3A)
G39  A 908 (-4.0A)
G39  A 908 (-2.8A)
G39  A 908 (-3.0A)
G39  A 908 (-4.6A)
 0.45A 4i00A-6eksA:
12.3		 4i00A-6eksA:
19.66
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4I00_A_ZMRA509_2
(NEURAMINIDASE)		 4b7j NEURAMINIDASE
(Influenza
A
virus) 		4 / 5 LEU A 134
ARG A 156
TRP A 179
ASN A 295
 None
None
None
G39  A1470 ( 3.7A)
 0.95A 4i00A-4b7jA:
64.0		 4i00A-4b7jA:
40.42
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4I00_A_ZMRA509_2
(NEURAMINIDASE)		 4hzz NEURAMINIDASE
(Influenza
A
virus) 		5 / 5 LEU A 134
ARG A 156
TRP A 178
ILE A 222
ASN A 294
 None
None
None
G39  A 509 ( 4.1A)
G39  A 509 ( 4.4A)
 0.19A 4i00A-4hzzA:
75.2		 4i00A-4hzzA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KR3_A_GLYA701_0
(GLYCINE--TRNA LIGASE)		 6eks SIALIDASE
(Vibrio
cholerae) 		4 / 6 ARG A 320
GLU A 645
ARG A 676
SER A 644
 None
G39  A 908 (-4.0A)
None
G39  A 908 ( 3.8A)
 1.35A 4kr3A-6eksA:
undetectable		 4kr3A-6eksA:
20.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LF7_A_PARA1817_1
(16S RRNA
RIBOSOMAL PROTEIN S9
RIBOSOMAL PROTEIN
S10)		 4yw5 NEURAMINIDASE C
(Streptococcus
pneumoniae) 		3 / 3 TYR A 695
ARG A 662
SER A 694
 G39  A 801 (-4.4A)
G39  A 801 (-2.9A)
None
 1.15A 4lf7I-4yw5A:
undetectable
4lf7J-4yw5A:
undetectable		 4lf7I-4yw5A:
11.95
4lf7J-4yw5A:
10.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LF8_A_PARA1817_1
(16S RRNA
RIBOSOMAL PROTEIN S9
RIBOSOMAL PROTEIN
S10)		 4yw5 NEURAMINIDASE C
(Streptococcus
pneumoniae) 		3 / 3 TYR A 695
ARG A 662
SER A 694
 G39  A 801 (-4.4A)
G39  A 801 (-2.9A)
None
 1.15A 4lf8I-4yw5A:
undetectable
4lf8J-4yw5A:
undetectable		 4lf8I-4yw5A:
11.95
4lf8J-4yw5A:
10.86
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4MWR_A_ZMRA513_1
(NEURAMINIDASE)		 4b7j NEURAMINIDASE
(Influenza
A
virus) 		10 / 12 ARG A 118
GLU A 119
ARG A 156
ARG A 225
GLU A 228
GLU A 277
GLU A 278
ARG A 293
ARG A 368
TYR A 402
 G39  A1470 (-3.1A)
G39  A1470 (-3.5A)
None
G39  A1470 (-4.4A)
None
G39  A1470 (-3.7A)
G39  A1470 (-4.2A)
G39  A1470 (-2.9A)
G39  A1470 (-3.0A)
G39  A1470 (-4.5A)
 0.61A 4mwrA-4b7jA:
64.3		 4mwrA-4b7jA:
40.76
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4MWR_A_ZMRA513_1
(NEURAMINIDASE)		 4b7j NEURAMINIDASE
(Influenza
A
virus) 		10 / 12 ARG A 118
GLU A 119
ARG A 156
ARG A 225
GLU A 228
GLU A 278
ARG A 293
ASN A 295
ARG A 368
TYR A 402
 G39  A1470 (-3.1A)
G39  A1470 (-3.5A)
None
G39  A1470 (-4.4A)
None
G39  A1470 (-4.2A)
G39  A1470 (-2.9A)
G39  A1470 ( 3.7A)
G39  A1470 (-3.0A)
G39  A1470 (-4.5A)
 0.43A 4mwrA-4b7jA:
64.3		 4mwrA-4b7jA:
40.76
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4MWR_A_ZMRA513_1
(NEURAMINIDASE)		 4hzz NEURAMINIDASE
(Influenza
A
virus) 		9 / 12 ARG A 118
GLU A 119
ARG A 156
ARG A 224
GLU A 227
ALA A 246
GLU A 276
GLU A 277
TYR A 406
 G39  A 509 (-3.0A)
G39  A 509 (-3.3A)
None
G39  A 509 (-4.7A)
None
G39  A 509 ( 4.1A)
G39  A 509 ( 4.1A)
G39  A 509 ( 4.0A)
G39  A 509 (-4.6A)
 0.59A 4mwrA-4hzzA:
63.0		 4mwrA-4hzzA:
48.61
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4MWR_A_ZMRA513_1
(NEURAMINIDASE)		 4hzz NEURAMINIDASE
(Influenza
A
virus) 		10 / 12 ARG A 118
GLU A 119
ARG A 156
ARG A 224
GLU A 227
ALA A 246
GLU A 277
ARG A 292
ARG A 371
TYR A 406
 G39  A 509 (-3.0A)
G39  A 509 (-3.3A)
None
G39  A 509 (-4.7A)
None
G39  A 509 ( 4.1A)
G39  A 509 ( 4.0A)
G39  A 509 (-2.8A)
G39  A 509 (-2.9A)
G39  A 509 (-4.6A)
 0.38A 4mwrA-4hzzA:
63.0		 4mwrA-4hzzA:
48.61
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4MWR_A_ZMRA513_1
(NEURAMINIDASE)		 4hzz NEURAMINIDASE
(Influenza
A
virus) 		9 / 12 GLU A 119
ARG A 156
ARG A 224
GLU A 227
ALA A 246
GLU A 276
GLU A 277
ASN A 294
TYR A 406
 G39  A 509 (-3.3A)
None
G39  A 509 (-4.7A)
None
G39  A 509 ( 4.1A)
G39  A 509 ( 4.1A)
G39  A 509 ( 4.0A)
G39  A 509 ( 4.4A)
G39  A 509 (-4.6A)
 0.89A 4mwrA-4hzzA:
63.0		 4mwrA-4hzzA:
48.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MWR_A_ZMRA513_1
(NEURAMINIDASE)		 4yw5 NEURAMINIDASE C
(Streptococcus
pneumoniae) 		5 / 12 ARG A 290
GLU A 584
ARG A 600
ARG A 662
TYR A 695
 G39  A 801 (-2.6A)
G39  A 801 ( 4.7A)
G39  A 801 (-2.9A)
G39  A 801 (-2.9A)
G39  A 801 (-4.4A)
 0.44A 4mwrA-4yw5A:
20.3		 4mwrA-4yw5A:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MWR_A_ZMRA513_1
(NEURAMINIDASE)		 6eks SIALIDASE
(Vibrio
cholerae) 		5 / 12 ARG A 250
GLU A 645
ARG A 661
ARG A 738
TYR A 766
 G39  A 908 (-2.8A)
G39  A 908 (-4.0A)
G39  A 908 (-2.8A)
G39  A 908 (-3.0A)
G39  A 908 (-4.6A)
 0.35A 4mwrA-6eksA:
20.7		 4mwrA-6eksA:
19.11
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4MWR_A_ZMRA513_2
(NEURAMINIDASE)		 4b7j NEURAMINIDASE
(Influenza
A
virus) 		4 / 5 LEU A 134
ASP A 151
ARG A 152
TRP A 179
 None
G39  A1470 (-3.7A)
G39  A1470 (-3.9A)
None
 0.26A 4mwrA-4b7jA:
64.3		 4mwrA-4b7jA:
40.76
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4MWR_A_ZMRA513_2
(NEURAMINIDASE)		 4hzz NEURAMINIDASE
(Influenza
A
virus) 		5 / 5 LEU A 134
ASP A 151
ARG A 152
TRP A 178
ILE A 222
 None
G39  A 509 (-3.6A)
G39  A 509 (-3.9A)
None
G39  A 509 ( 4.1A)
 0.19A 4mwrA-4hzzA:
63.0		 4mwrA-4hzzA:
48.61
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4MWV_A_BCZA513_0
(NEURAMINIDASE)		 4b7j NEURAMINIDASE
(Influenza
A
virus) 		11 / 12 GLU A 119
LEU A 134
ASP A 151
ARG A 152
ARG A 156
TRP A 179
ARG A 225
GLU A 277
GLU A 278
ARG A 293
TYR A 402
 G39  A1470 (-3.5A)
None
G39  A1470 (-3.7A)
G39  A1470 (-3.9A)
None
None
G39  A1470 (-4.4A)
G39  A1470 (-3.7A)
G39  A1470 (-4.2A)
G39  A1470 (-2.9A)
G39  A1470 (-4.5A)
 0.42A 4mwvA-4b7jA:
64.2		 4mwvA-4b7jA:
40.76
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4MWV_A_BCZA513_0
(NEURAMINIDASE)		 4hzz NEURAMINIDASE
(Influenza
A
virus) 		5 / 12 ASP A 151
ARG A 152
ILE A 222
ARG A 224
GLU A 227
 G39  A 509 (-3.6A)
G39  A 509 (-3.9A)
G39  A 509 ( 4.1A)
G39  A 509 (-4.7A)
None
 1.27A 4mwvA-4hzzA:
63.0		 4mwvA-4hzzA:
48.61
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4MWV_A_BCZA513_0
(NEURAMINIDASE)		 4hzz NEURAMINIDASE
(Influenza
A
virus) 		12 / 12 GLU A 119
LEU A 134
ASP A 151
ARG A 152
ARG A 156
TRP A 178
ILE A 222
ARG A 224
GLU A 276
GLU A 277
ARG A 292
TYR A 406
 G39  A 509 (-3.3A)
None
G39  A 509 (-3.6A)
G39  A 509 (-3.9A)
None
None
G39  A 509 ( 4.1A)
G39  A 509 (-4.7A)
G39  A 509 ( 4.1A)
G39  A 509 ( 4.0A)
G39  A 509 (-2.8A)
G39  A 509 (-4.6A)
 0.21A 4mwvA-4hzzA:
63.0		 4mwvA-4hzzA:
48.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MWV_A_BCZA513_0
(NEURAMINIDASE)		 6eks SIALIDASE
(Vibrio
cholerae) 		5 / 12 ASP A 276
TRP A 337
GLU A 645
ARG A 661
TYR A 766
 G39  A 908 (-3.3A)
None
G39  A 908 (-4.0A)
G39  A 908 (-2.8A)
G39  A 908 (-4.6A)
 0.58A 4mwvA-6eksA:
8.1		 4mwvA-6eksA:
19.11
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4MWV_A_BCZA513_1
(NEURAMINIDASE)		 4b7j NEURAMINIDASE
(Influenza
A
virus) 		3 / 3 ARG A 118
GLU A 228
ARG A 368
 G39  A1470 (-3.1A)
None
G39  A1470 (-3.0A)
 0.20A 4mwvA-4b7jA:
64.2		 4mwvA-4b7jA:
40.76
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4MWV_A_BCZA513_1
(NEURAMINIDASE)		 4hzz NEURAMINIDASE
(Influenza
A
virus) 		3 / 3 ARG A 118
GLU A 227
ARG A 371
 G39  A 509 (-3.0A)
None
G39  A 509 (-2.9A)
 0.20A 4mwvA-4hzzA:
63.0		 4mwvA-4hzzA:
48.61
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4MWX_A_ZMRA513_1
(NEURAMINIDASE)		 4b7j NEURAMINIDASE
(Influenza
A
virus) 		10 / 12 ARG A 118
GLU A 119
ASP A 151
ARG A 156
ARG A 225
GLU A 228
GLU A 277
GLU A 278
ARG A 368
TYR A 402
 G39  A1470 (-3.1A)
G39  A1470 (-3.5A)
G39  A1470 (-3.7A)
None
G39  A1470 (-4.4A)
None
G39  A1470 (-3.7A)
G39  A1470 (-4.2A)
G39  A1470 (-3.0A)
G39  A1470 (-4.5A)
 0.62A 4mwxA-4b7jA:
64.2		 4mwxA-4b7jA:
40.55
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4MWX_A_ZMRA513_1
(NEURAMINIDASE)		 4hzz NEURAMINIDASE
(Influenza
A
virus) 		11 / 12 ARG A 118
GLU A 119
ASP A 151
ARG A 156
ARG A 224
GLU A 227
ALA A 246
GLU A 276
GLU A 277
ARG A 371
TYR A 406
 G39  A 509 (-3.0A)
G39  A 509 (-3.3A)
G39  A 509 (-3.6A)
None
G39  A 509 (-4.7A)
None
G39  A 509 ( 4.1A)
G39  A 509 ( 4.1A)
G39  A 509 ( 4.0A)
G39  A 509 (-2.9A)
G39  A 509 (-4.6A)
 0.61A 4mwxA-4hzzA:
63.0		 4mwxA-4hzzA:
48.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MWX_A_ZMRA513_1
(NEURAMINIDASE)		 4yw5 NEURAMINIDASE C
(Streptococcus
pneumoniae) 		5 / 12 ARG A 290
ASP A 315
GLU A 584
ARG A 662
TYR A 695
 G39  A 801 (-2.6A)
G39  A 801 (-3.2A)
G39  A 801 ( 4.7A)
G39  A 801 (-2.9A)
G39  A 801 (-4.4A)
 0.76A 4mwxA-4yw5A:
7.6		 4mwxA-4yw5A:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MWX_A_ZMRA513_1
(NEURAMINIDASE)		 6eks SIALIDASE
(Vibrio
cholerae) 		5 / 12 ARG A 250
ASP A 276
GLU A 645
ARG A 738
TYR A 766
 G39  A 908 (-2.8A)
G39  A 908 (-3.3A)
G39  A 908 (-4.0A)
G39  A 908 (-3.0A)
G39  A 908 (-4.6A)
 0.47A 4mwxA-6eksA:
5.6		 4mwxA-6eksA:
18.98
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4MWX_A_ZMRA513_2
(NEURAMINIDASE)		 4hzz NEURAMINIDASE
(Influenza
A
virus) 		3 / 3 ARG A 152
TRP A 178
ILE A 222
 G39  A 509 (-3.9A)
None
G39  A 509 ( 4.1A)
 0.14A 4mwxA-4hzzA:
63.0		 4mwxA-4hzzA:
48.36
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4MX0_A_BCZA513_0
(NEURAMINIDASE)		 4b7j NEURAMINIDASE
(Influenza
A
virus) 		11 / 12 GLU A 119
LEU A 134
ARG A 152
ARG A 156
TRP A 179
SER A 180
ARG A 225
GLU A 228
GLU A 277
GLU A 278
TYR A 402
 G39  A1470 (-3.5A)
None
G39  A1470 (-3.9A)
None
None
G39  A1470 ( 4.5A)
G39  A1470 (-4.4A)
None
G39  A1470 (-3.7A)
G39  A1470 (-4.2A)
G39  A1470 (-4.5A)
 0.41A 4mx0A-4b7jA:
64.2		 4mx0A-4b7jA:
40.55
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4MX0_A_BCZA513_0
(NEURAMINIDASE)		 4hzz NEURAMINIDASE
(Influenza
A
virus) 		12 / 12 GLU A 119
LEU A 134
ARG A 152
ARG A 156
TRP A 178
SER A 179
ARG A 224
GLU A 227
ALA A 246
GLU A 276
GLU A 277
TYR A 406
 G39  A 509 (-3.3A)
None
G39  A 509 (-3.9A)
None
None
G39  A 509 ( 4.5A)
G39  A 509 (-4.7A)
None
G39  A 509 ( 4.1A)
G39  A 509 ( 4.1A)
G39  A 509 ( 4.0A)
G39  A 509 (-4.6A)
 0.39A 4mx0A-4hzzA:
62.9		 4mx0A-4hzzA:
48.36
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4MX0_A_BCZA513_1
(NEURAMINIDASE)		 4b7j NEURAMINIDASE
(Influenza
A
virus) 		3 / 3 ARG A 118
ASP A 151
ARG A 368
 G39  A1470 (-3.1A)
G39  A1470 (-3.7A)
G39  A1470 (-3.0A)
 0.23A 4mx0A-4b7jA:
64.2		 4mx0A-4b7jA:
40.55
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4MX0_A_BCZA513_1
(NEURAMINIDASE)		 4hzz NEURAMINIDASE
(Influenza
A
virus) 		3 / 3 ARG A 118
ASP A 151
ARG A 371
 G39  A 509 (-3.0A)
G39  A 509 (-3.6A)
G39  A 509 (-2.9A)
 0.19A 4mx0A-4hzzA:
62.9		 4mx0A-4hzzA:
48.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MX0_A_BCZA513_1
(NEURAMINIDASE)		 4yw5 NEURAMINIDASE C
(Streptococcus
pneumoniae) 		3 / 3 ARG A 290
ASP A 315
ARG A 662
 G39  A 801 (-2.6A)
G39  A 801 (-3.2A)
G39  A 801 (-2.9A)
 0.77A 4mx0A-4yw5A:
4.5		 4mx0A-4yw5A:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MX0_A_BCZA513_1
(NEURAMINIDASE)		 6eks SIALIDASE
(Vibrio
cholerae) 		3 / 3 ARG A 250
ASP A 276
ARG A 738
 G39  A 908 (-2.8A)
G39  A 908 (-3.3A)
G39  A 908 (-3.0A)
 0.37A 4mx0A-6eksA:
6.0		 4mx0A-6eksA:
18.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4URO_A_NOVA2000_1
(DNA GYRASE SUBUNIT B)		 6eks SIALIDASE
(Vibrio
cholerae) 		5 / 12 GLU A 269
PRO A 574
ASP A 647
ILE A 599
SER A 569
 G39  A 908 ( 4.7A)
CA  A 903 (-4.4A)
CA  A 903 (-2.1A)
None
None
 1.19A 4uroA-6eksA:
undetectable		 4uroA-6eksA:
15.06
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4WA5_A_ZMRA501_1
(NEURAMINIDASE)		 4b7j NEURAMINIDASE
(Influenza
A
virus) 		10 / 12 ARG A 118
GLU A 119
ASP A 151
GLU A 228
GLU A 277
GLU A 278
ARG A 293
ASN A 295
ARG A 368
TYR A 402
 G39  A1470 (-3.1A)
G39  A1470 (-3.5A)
G39  A1470 (-3.7A)
None
G39  A1470 (-3.7A)
G39  A1470 (-4.2A)
G39  A1470 (-2.9A)
G39  A1470 ( 3.7A)
G39  A1470 (-3.0A)
G39  A1470 (-4.5A)
 0.69A 4wa5A-4b7jA:
67.8		 4wa5A-4b7jA:
49.36
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4WA5_A_ZMRA501_1
(NEURAMINIDASE)		 4hzz NEURAMINIDASE
(Influenza
A
virus) 		10 / 12 ARG A 118
GLU A 119
ASP A 151
GLU A 227
ALA A 246
GLU A 276
GLU A 277
ARG A 292
ARG A 371
TYR A 406
 G39  A 509 (-3.0A)
G39  A 509 (-3.3A)
G39  A 509 (-3.6A)
None
G39  A 509 ( 4.1A)
G39  A 509 ( 4.1A)
G39  A 509 ( 4.0A)
G39  A 509 (-2.8A)
G39  A 509 (-2.9A)
G39  A 509 (-4.6A)
 0.66A 4wa5A-4hzzA:
62.1		 4wa5A-4hzzA:
47.46
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4WA5_A_ZMRA501_1
(NEURAMINIDASE)		 4hzz NEURAMINIDASE
(Influenza
A
virus) 		8 / 12 GLU A 119
ASP A 151
GLU A 227
ALA A 246
GLU A 276
GLU A 277
ASN A 294
TYR A 406
 G39  A 509 (-3.3A)
G39  A 509 (-3.6A)
None
G39  A 509 ( 4.1A)
G39  A 509 ( 4.1A)
G39  A 509 ( 4.0A)
G39  A 509 ( 4.4A)
G39  A 509 (-4.6A)
 0.95A 4wa5A-4hzzA:
62.1		 4wa5A-4hzzA:
47.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WA5_A_ZMRA501_1
(NEURAMINIDASE)		 4yw5 NEURAMINIDASE C
(Streptococcus
pneumoniae) 		5 / 12 ARG A 290
GLU A 584
ARG A 600
ARG A 662
TYR A 695
 G39  A 801 (-2.6A)
G39  A 801 ( 4.7A)
G39  A 801 (-2.9A)
G39  A 801 (-2.9A)
G39  A 801 (-4.4A)
 0.44A 4wa5A-4yw5A:
10.3		 4wa5A-4yw5A:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WA5_A_ZMRA501_1
(NEURAMINIDASE)		 6eks SIALIDASE
(Vibrio
cholerae) 		5 / 12 ARG A 250
ASP A 276
ARG A 661
ARG A 738
TYR A 766
 G39  A 908 (-2.8A)
G39  A 908 (-3.3A)
G39  A 908 (-2.8A)
G39  A 908 (-3.0A)
G39  A 908 (-4.6A)
 0.65A 4wa5A-6eksA:
3.7		 4wa5A-6eksA:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WA5_A_ZMRA501_1
(NEURAMINIDASE)		 6eks SIALIDASE
(Vibrio
cholerae) 		5 / 12 ARG A 250
GLU A 645
ARG A 661
ARG A 738
TYR A 766
 G39  A 908 (-2.8A)
G39  A 908 (-4.0A)
G39  A 908 (-2.8A)
G39  A 908 (-3.0A)
G39  A 908 (-4.6A)
 0.34A 4wa5A-6eksA:
3.7		 4wa5A-6eksA:
20.91
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4WA5_A_ZMRA501_2
(NEURAMINIDASE)		 4b7j NEURAMINIDASE
(Influenza
A
virus) 		4 / 5 ARG A 152
ARG A 156
TRP A 179
ARG A 225
 G39  A1470 (-3.9A)
None
None
G39  A1470 (-4.4A)
 0.65A 4wa5A-4b7jA:
67.8		 4wa5A-4b7jA:
49.36
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4WA5_A_ZMRA501_2
(NEURAMINIDASE)		 4hzz NEURAMINIDASE
(Influenza
A
virus) 		5 / 5 ARG A 152
ARG A 156
TRP A 178
ILE A 222
ARG A 224
 G39  A 509 (-3.9A)
None
None
G39  A 509 ( 4.1A)
G39  A 509 (-4.7A)
 0.54A 4wa5A-4hzzA:
62.1		 4wa5A-4hzzA:
47.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IQB_A_KANA600_1
(BIFUNCTIONAL AAC/APH)		 4hzz NEURAMINIDASE
(Influenza
A
virus) 		5 / 12 SER A 179
ASP A 198
GLU A 119
GLU A 277
GLU A 227
 G39  A 509 ( 4.5A)
None
G39  A 509 (-3.3A)
G39  A 509 ( 4.0A)
None
 1.47A 5iqbA-4hzzA:
undetectable		 5iqbA-4hzzA:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IQB_B_KANB600_1
(BIFUNCTIONAL AAC/APH)		 4hzz NEURAMINIDASE
(Influenza
A
virus) 		5 / 11 SER A 179
ASP A 198
GLU A 119
GLU A 277
GLU A 227
 G39  A 509 ( 4.5A)
None
G39  A 509 (-3.3A)
G39  A 509 ( 4.0A)
None
 1.46A 5iqbB-4hzzA:
undetectable		 5iqbB-4hzzA:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IQB_C_KANC600_1
(BIFUNCTIONAL AAC/APH)		 4hzz NEURAMINIDASE
(Influenza
A
virus) 		5 / 11 SER A 179
ASP A 198
GLU A 119
GLU A 277
GLU A 227
 G39  A 509 ( 4.5A)
None
G39  A 509 (-3.3A)
G39  A 509 ( 4.0A)
None
 1.47A 5iqbC-4hzzA:
0.5		 5iqbC-4hzzA:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IQB_D_KAND600_1
(BIFUNCTIONAL AAC/APH)		 4hzz NEURAMINIDASE
(Influenza
A
virus) 		5 / 12 SER A 179
ASP A 198
GLU A 119
GLU A 277
GLU A 227
 G39  A 509 ( 4.5A)
None
G39  A 509 (-3.3A)
G39  A 509 ( 4.0A)
None
 1.47A 5iqbD-4hzzA:
undetectable		 5iqbD-4hzzA:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IQC_A_51GA600_1
(BIFUNCTIONAL AAC/APH)		 4hzz NEURAMINIDASE
(Influenza
A
virus) 		5 / 10 SER A 179
ASP A 198
GLU A 119
GLU A 277
GLU A 227
 G39  A 509 ( 4.5A)
None
G39  A 509 (-3.3A)
G39  A 509 ( 4.0A)
None
 1.46A 5iqcA-4hzzA:
0.5		 5iqcA-4hzzA:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IQC_B_51GB600_1
(BIFUNCTIONAL AAC/APH)		 4hzz NEURAMINIDASE
(Influenza
A
virus) 		5 / 10 SER A 179
ASP A 198
GLU A 119
GLU A 277
GLU A 227
 G39  A 509 ( 4.5A)
None
G39  A 509 (-3.3A)
G39  A 509 ( 4.0A)
None
 1.48A 5iqcB-4hzzA:
0.8		 5iqcB-4hzzA:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IQC_C_51GC600_1
(BIFUNCTIONAL AAC/APH)		 4hzz NEURAMINIDASE
(Influenza
A
virus) 		5 / 10 SER A 179
ASP A 198
GLU A 119
GLU A 277
GLU A 227
 G39  A 509 ( 4.5A)
None
G39  A 509 (-3.3A)
G39  A 509 ( 4.0A)
None
 1.48A 5iqcC-4hzzA:
0.8		 5iqcC-4hzzA:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IQC_D_51GD600_1
(BIFUNCTIONAL AAC/APH)		 4hzz NEURAMINIDASE
(Influenza
A
virus) 		5 / 10 SER A 179
ASP A 198
GLU A 119
GLU A 277
GLU A 227
 G39  A 509 ( 4.5A)
None
G39  A 509 (-3.3A)
G39  A 509 ( 4.0A)
None
 1.47A 5iqcD-4hzzA:
0.0		 5iqcD-4hzzA:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IQE_A_NMYA600_1
(BIFUNCTIONAL AAC/APH)		 4hzz NEURAMINIDASE
(Influenza
A
virus) 		5 / 11 SER A 179
ASP A 198
GLU A 119
GLU A 277
GLU A 227
 G39  A 509 ( 4.5A)
None
G39  A 509 (-3.3A)
G39  A 509 ( 4.0A)
None
 1.48A 5iqeA-4hzzA:
0.9		 5iqeA-4hzzA:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IQE_B_NMYB600_1
(BIFUNCTIONAL AAC/APH)		 4hzz NEURAMINIDASE
(Influenza
A
virus) 		5 / 10 SER A 179
ASP A 198
GLU A 119
GLU A 277
GLU A 227
 G39  A 509 ( 4.5A)
None
G39  A 509 (-3.3A)
G39  A 509 ( 4.0A)
None
 1.48A 5iqeB-4hzzA:
0.8		 5iqeB-4hzzA:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IQE_D_NMYD600_1
(BIFUNCTIONAL AAC/APH)		 4hzz NEURAMINIDASE
(Influenza
A
virus) 		5 / 12 SER A 179
ASP A 198
GLU A 119
GLU A 277
GLU A 227
 G39  A 509 ( 4.5A)
None
G39  A 509 (-3.3A)
G39  A 509 ( 4.0A)
None
 1.47A 5iqeD-4hzzA:
undetectable		 5iqeD-4hzzA:
22.03
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5L17_A_ZMRA512_1
(NEURAMINIDASE)		 4b7j NEURAMINIDASE
(Influenza
A
virus) 		11 / 12 ARG A 118
GLU A 119
ASP A 151
ARG A 156
ARG A 225
GLU A 228
GLU A 277
GLU A 278
ARG A 293
ARG A 368
TYR A 402
 G39  A1470 (-3.1A)
G39  A1470 (-3.5A)
G39  A1470 (-3.7A)
None
G39  A1470 (-4.4A)
None
G39  A1470 (-3.7A)
G39  A1470 (-4.2A)
G39  A1470 (-2.9A)
G39  A1470 (-3.0A)
G39  A1470 (-4.5A)
 0.54A 5l17A-4b7jA:
64.5		 5l17A-4b7jA:
42.52
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5L17_A_ZMRA512_1
(NEURAMINIDASE)		 4hzz NEURAMINIDASE
(Influenza
A
virus) 		11 / 12 ARG A 118
GLU A 119
ASP A 151
ARG A 156
ARG A 224
GLU A 227
ALA A 246
GLU A 276
GLU A 277
ARG A 371
TYR A 406
 G39  A 509 (-3.0A)
G39  A 509 (-3.3A)
G39  A 509 (-3.6A)
None
G39  A 509 (-4.7A)
None
G39  A 509 ( 4.1A)
G39  A 509 ( 4.1A)
G39  A 509 ( 4.0A)
G39  A 509 (-2.9A)
G39  A 509 (-4.6A)
 0.53A 5l17A-4hzzA:
63.0		 5l17A-4hzzA:
47.54
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5L17_A_ZMRA512_1
(NEURAMINIDASE)		 4hzz NEURAMINIDASE
(Influenza
A
virus) 		11 / 12 ARG A 118
GLU A 119
ASP A 151
ARG A 156
ARG A 224
GLU A 227
ALA A 246
GLU A 277
ARG A 292
ARG A 371
TYR A 406
 G39  A 509 (-3.0A)
G39  A 509 (-3.3A)
G39  A 509 (-3.6A)
None
G39  A 509 (-4.7A)
None
G39  A 509 ( 4.1A)
G39  A 509 ( 4.0A)
G39  A 509 (-2.8A)
G39  A 509 (-2.9A)
G39  A 509 (-4.6A)
 0.37A 5l17A-4hzzA:
63.0		 5l17A-4hzzA:
47.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L17_A_ZMRA512_1
(NEURAMINIDASE)		 4yw5 NEURAMINIDASE C
(Streptococcus
pneumoniae) 		6 / 12 ARG A 290
ASP A 315
GLU A 584
ARG A 600
ARG A 662
TYR A 695
 G39  A 801 (-2.6A)
G39  A 801 (-3.2A)
G39  A 801 ( 4.7A)
G39  A 801 (-2.9A)
G39  A 801 (-2.9A)
G39  A 801 (-4.4A)
 0.72A 5l17A-4yw5A:
7.7		 5l17A-4yw5A:
20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L17_A_ZMRA512_1
(NEURAMINIDASE)		 6eks SIALIDASE
(Vibrio
cholerae) 		6 / 12 ARG A 250
ASP A 276
GLU A 645
ARG A 661
ARG A 738
TYR A 766
 G39  A 908 (-2.8A)
G39  A 908 (-3.3A)
G39  A 908 (-4.0A)
G39  A 908 (-2.8A)
G39  A 908 (-3.0A)
G39  A 908 (-4.6A)
 0.44A 5l17A-6eksA:
20.6		 5l17A-6eksA:
19.24
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5L17_A_ZMRA512_2
(NEURAMINIDASE)		 4hzz NEURAMINIDASE
(Influenza
A
virus) 		4 / 4 LEU A 134
ARG A 152
TRP A 178
ILE A 222
 None
G39  A 509 (-3.9A)
None
G39  A 509 ( 4.1A)
 0.15A 5l17A-4hzzA:
63.0		 5l17A-4hzzA:
47.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L66_K_BO2K301_1
(PROTEASOME SUBUNIT
BETA
TYPE-8,PROTEASOME
SUBUNIT BETA TYPE-5
PROTEASOME SUBUNIT
BETA
TYPE-6,PROTEASOME
SUBUNIT BETA
TYPE-1,PROTEASOME
SUBUNIT BETA
TYPE-6,PROTEASOME
SUBUNIT BETA
TYPE-1,PROTEASOME
SUBUNIT BETA TYPE-6)		 6eks SIALIDASE
(Vibrio
cholerae) 		5 / 10 ALA A 342
GLY A 355
ALA A 335
ASP A 318
SER A 317
 None
None
None
G39  A 908 ( 4.2A)
G39  A 908 ( 4.6A)
 1.45A 5l66K-6eksA:
undetectable
5l66L-6eksA:
undetectable		 5l66K-6eksA:
14.44
5l66L-6eksA:
14.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L66_Y_BO2Y301_1
(PROTEASOME SUBUNIT
BETA
TYPE-8,PROTEASOME
SUBUNIT BETA TYPE-5
PROTEASOME SUBUNIT
BETA
TYPE-6,PROTEASOME
SUBUNIT BETA
TYPE-1,PROTEASOME
SUBUNIT BETA
TYPE-6,PROTEASOME
SUBUNIT BETA
TYPE-1,PROTEASOME
SUBUNIT BETA TYPE-6)		 6eks SIALIDASE
(Vibrio
cholerae) 		5 / 10 ALA A 342
GLY A 355
ALA A 335
ASP A 318
SER A 317
 None
None
None
G39  A 908 ( 4.2A)
G39  A 908 ( 4.6A)
 1.44A 5l66Y-6eksA:
undetectable
5l66Z-6eksA:
undetectable		 5l66Y-6eksA:
14.44
5l66Z-6eksA:
14.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M54_E_TA1E502_1
(TUBULIN BETA-2B
CHAIN)		 6eks SIALIDASE
(Vibrio
cholerae) 		5 / 12 ALA A 709
SER A 767
PHE A 725
ARG A 738
GLY A 705
 None
None
None
G39  A 908 (-3.0A)
None
 1.15A 5m54E-6eksA:
undetectable		 5m54E-6eksA:
20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X7P_A_ACRA1481_1
(GLYCOSIDE HYDROLASE
FAMILY 31
ALPHA-GLUCOSIDASE)		 4yw5 NEURAMINIDASE C
(Streptococcus
pneumoniae) 		4 / 6 SER A 696
ARG A 290
GLU A 711
TYR A 695
 None
G39  A 801 (-2.6A)
None
G39  A 801 (-4.4A)
 1.15A 5x7pA-4yw5A:
4.1		 5x7pA-4yw5A:
19.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X7P_B_ACRB1481_1
(GLYCOSIDE HYDROLASE
FAMILY 31
ALPHA-GLUCOSIDASE)		 4yw5 NEURAMINIDASE C
(Streptococcus
pneumoniae) 		4 / 6 SER A 696
ARG A 290
GLU A 711
TYR A 695
 None
G39  A 801 (-2.6A)
None
G39  A 801 (-4.4A)
 1.20A 5x7pB-4yw5A:
4.2		 5x7pB-4yw5A:
19.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X7Q_A_ACRA1481_1
(GLYCOSIDE HYDROLASE
FAMILY 31
ALPHA-GLUCOSIDASE)		 4yw5 NEURAMINIDASE C
(Streptococcus
pneumoniae) 		4 / 6 SER A 696
ARG A 290
GLU A 711
TYR A 695
 None
G39  A 801 (-2.6A)
None
G39  A 801 (-4.4A)
 1.19A 5x7qA-4yw5A:
4.0		 5x7qA-4yw5A:
19.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X7Q_B_ACRB1481_1
(GLYCOSIDE HYDROLASE
FAMILY 31
ALPHA-GLUCOSIDASE)		 4yw5 NEURAMINIDASE C
(Streptococcus
pneumoniae) 		4 / 6 SER A 696
ARG A 290
GLU A 711
TYR A 695
 None
G39  A 801 (-2.6A)
None
G39  A 801 (-4.4A)
 1.18A 5x7qB-4yw5A:
4.2		 5x7qB-4yw5A:
19.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X7R_A_ACRA1481_1
(GLYCOSIDE HYDROLASE
FAMILY 31
ALPHA-GLUCOSIDASE)		 4yw5 NEURAMINIDASE C
(Streptococcus
pneumoniae) 		4 / 6 SER A 696
ARG A 290
GLU A 711
TYR A 695
 None
G39  A 801 (-2.6A)
None
G39  A 801 (-4.4A)
 1.19A 5x7rA-4yw5A:
undetectable		 5x7rA-4yw5A:
19.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EKU_A_ZMRA901_1
(SIALIDASE)		 4b7j NEURAMINIDASE
(Influenza
A
virus) 		5 / 12 ARG A 118
GLU A 278
ARG A 293
ARG A 368
TYR A 402
 G39  A1470 (-3.1A)
G39  A1470 (-4.2A)
G39  A1470 (-2.9A)
G39  A1470 (-3.0A)
G39  A1470 (-4.5A)
 0.33A 6ekuA-4b7jA:
12.0		 6ekuA-4b7jA:
22.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EKU_A_ZMRA901_1
(SIALIDASE)		 4hzz NEURAMINIDASE
(Influenza
A
virus) 		5 / 12 ARG A 118
GLU A 277
ARG A 292
ARG A 371
TYR A 406
 G39  A 509 (-3.0A)
G39  A 509 ( 4.0A)
G39  A 509 (-2.8A)
G39  A 509 (-2.9A)
G39  A 509 (-4.6A)
 0.33A 6ekuA-4hzzA:
11.7		 6ekuA-4hzzA:
19.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EKU_A_ZMRA901_1
(SIALIDASE)		 4yw5 NEURAMINIDASE C
(Streptococcus
pneumoniae) 		7 / 12 ARG A 290
ILE A 291
ARG A 309
GLU A 584
ARG A 600
ARG A 662
TYR A 695
 G39  A 801 (-2.6A)
None
G39  A 801 (-4.3A)
G39  A 801 ( 4.7A)
G39  A 801 (-2.9A)
G39  A 801 (-2.9A)
G39  A 801 (-4.4A)
 0.48A 6ekuA-4yw5A:
37.1		 6ekuA-4yw5A:
25.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EKU_A_ZMRA901_1
(SIALIDASE)		 4yw5 NEURAMINIDASE C
(Streptococcus
pneumoniae) 		6 / 12 ILE A 291
ASP A 372
GLU A 584
ARG A 600
ARG A 662
TYR A 695
 None
G39  A 801 (-2.6A)
G39  A 801 ( 4.7A)
G39  A 801 (-2.9A)
G39  A 801 (-2.9A)
G39  A 801 (-4.4A)
 0.74A 6ekuA-4yw5A:
37.1		 6ekuA-4yw5A:
25.52
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6EKU_A_ZMRA901_1
(SIALIDASE)		 6eks SIALIDASE
(Vibrio
cholerae) 		12 / 12 ARG A 250
ILE A 251
GLU A 269
ARG A 271
PRO A 277
ASP A 318
ASN A 344
GLU A 645
ARG A 661
ASP A 663
ARG A 738
TYR A 766
 G39  A 908 (-2.8A)
G39  A 908 (-4.7A)
G39  A 908 ( 4.7A)
G39  A 908 (-4.2A)
G39  A 908 ( 4.4A)
G39  A 908 ( 4.2A)
G39  A 908 (-3.5A)
G39  A 908 (-4.0A)
G39  A 908 (-2.8A)
G39  A 908 (-3.8A)
G39  A 908 (-3.0A)
G39  A 908 (-4.6A)
 0.30A 6ekuA-6eksA:
71.0		 6ekuA-6eksA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6EKU_A_ZMRA901_2
(SIALIDASE)		 6eks SIALIDASE
(Vibrio
cholerae) 		6 / 6 ASP A 276
GLN A 343
ASN A 571
LEU A 606
SER A 644
PHE A 664
 G39  A 908 (-3.3A)
G39  A 908 (-3.8A)
G39  A 908 (-4.5A)
None
G39  A 908 ( 3.8A)
None
 0.34A 6ekuA-6eksA:
71.0		 6ekuA-6eksA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HCX_A_ZMRA519_0
(NEURAMINIDASE)		 4b7j NEURAMINIDASE
(Influenza
A
virus) 		11 / 12 ARG A 118
GLU A 119
ASP A 151
ARG A 152
ARG A 156
ARG A 225
GLU A 228
GLU A 277
ARG A 293
ARG A 368
TYR A 402
 G39  A1470 (-3.1A)
G39  A1470 (-3.5A)
G39  A1470 (-3.7A)
G39  A1470 (-3.9A)
None
G39  A1470 (-4.4A)
None
G39  A1470 (-3.7A)
G39  A1470 (-2.9A)
G39  A1470 (-3.0A)
G39  A1470 (-4.5A)
 0.59A 6hcxA-4b7jA:
64.4		 6hcxA-4b7jA:
10.72
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6HCX_A_ZMRA519_0
(NEURAMINIDASE)		 4hzz NEURAMINIDASE
(Influenza
A
virus) 		11 / 12 ARG A 118
GLU A 119
ASP A 151
ARG A 152
ARG A 156
ARG A 224
GLU A 227
ALA A 246
ARG A 292
ARG A 371
TYR A 406
 G39  A 509 (-3.0A)
G39  A 509 (-3.3A)
G39  A 509 (-3.6A)
G39  A 509 (-3.9A)
None
G39  A 509 (-4.7A)
None
G39  A 509 ( 4.1A)
G39  A 509 (-2.8A)
G39  A 509 (-2.9A)
G39  A 509 (-4.6A)
 0.42A 6hcxA-4hzzA:
63.1		 6hcxA-4hzzA:
31.88
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6HCX_A_ZMRA519_0
(NEURAMINIDASE)		 4hzz NEURAMINIDASE
(Influenza
A
virus) 		11 / 12 ARG A 118
GLU A 119
ASP A 151
ARG A 152
ARG A 156
ARG A 224
GLU A 227
ALA A 246
GLU A 276
ARG A 371
TYR A 406
 G39  A 509 (-3.0A)
G39  A 509 (-3.3A)
G39  A 509 (-3.6A)
G39  A 509 (-3.9A)
None
G39  A 509 (-4.7A)
None
G39  A 509 ( 4.1A)
G39  A 509 ( 4.1A)
G39  A 509 (-2.9A)
G39  A 509 (-4.6A)
 0.58A 6hcxA-4hzzA:
63.1		 6hcxA-4hzzA:
31.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HCX_A_ZMRA519_0
(NEURAMINIDASE)		 4yw5 NEURAMINIDASE C
(Streptococcus
pneumoniae) 		5 / 12 ARG A 290
ASP A 315
ARG A 600
ARG A 662
TYR A 695
 G39  A 801 (-2.6A)
G39  A 801 (-3.2A)
G39  A 801 (-2.9A)
G39  A 801 (-2.9A)
G39  A 801 (-4.4A)
 0.76A 6hcxA-4yw5A:
8.1		 6hcxA-4yw5A:
9.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HCX_A_ZMRA519_0
(NEURAMINIDASE)		 6eks SIALIDASE
(Vibrio
cholerae) 		5 / 12 ARG A 250
ASP A 276
ARG A 661
ARG A 738
TYR A 766
 G39  A 908 (-2.8A)
G39  A 908 (-3.3A)
G39  A 908 (-2.8A)
G39  A 908 (-3.0A)
G39  A 908 (-4.6A)
 0.42A 6hcxA-6eksA:
20.7		 6hcxA-6eksA:
7.54
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6HCX_A_ZMRA519_1
(NEURAMINIDASE)		 4hzz NEURAMINIDASE
(Influenza
A
virus) 		3 / 3 TRP A 178
ILE A 222
GLU A 277
 None
G39  A 509 ( 4.1A)
G39  A 509 ( 4.0A)
 0.19A 6hcxA-4hzzA:
63.1		 6hcxA-4hzzA:
31.88