SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'G2P'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DSC_C_DVAC2_0
(ACTINOMYCIN D)		 1w5f CELL DIVISION
PROTEIN FTSZ
(Thermotoga
maritima) 		3 / 3 THR A 119
PRO A  85
THR A 121
 G2P  A 500 (-3.6A)
None
None
 0.97A 1dscC-1w5fA:
undetectable		 1dscC-1w5fA:
3.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JGS_A_SALA256_1
(MULTIPLE ANTIBIOTIC
RESISTANCE PROTEIN
MARR)		 2bz0 GTP CYCLOHYDROLASE
II
(Escherichia
coli) 		4 / 7 VAL A  50
LEU A 147
THR A 149
LEU A 171
 None
None
G2P  A1176 (-3.7A)
None
 0.88A 1jgsA-2bz0A:
undetectable		 1jgsA-2bz0A:
23.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P91_A_SAMA1401_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE A)		 5n5n TUBULIN BETA CHAIN
(Homo
sapiens) 		5 / 11 LEU B 141
GLY B 148
GLY B 146
ILE B 154
LEU B 428
 None
None
G2P  B 501 (-3.5A)
None
None
 1.01A 1p91A-5n5nB:
2.3		 1p91A-5n5nB:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RJD_A_SAMA801_0
(CARBOXY METHYL
TRANSFERASE FOR
PROTEIN PHOSPHATASE
2A CATALYTIC SUBUNIT)		 5n5n TUBULIN BETA CHAIN
(Homo
sapiens) 		5 / 12 ALA B  99
GLY B 150
GLY B 148
SER B 190
LEU B 137
 G2P  B 501 ( 4.6A)
None
None
None
None
 1.01A 1rjdA-5n5nB:
3.5		 1rjdA-5n5nB:
22.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RJD_B_SAMB802_0
(CARBOXY METHYL
TRANSFERASE FOR
PROTEIN PHOSPHATASE
2A CATALYTIC SUBUNIT)		 5n5n TUBULIN BETA CHAIN
(Homo
sapiens) 		5 / 12 ALA B  99
GLY B 150
GLY B 148
SER B 190
LEU B 137
 G2P  B 501 ( 4.6A)
None
None
None
None
 1.02A 1rjdB-5n5nB:
undetectable		 1rjdB-5n5nB:
22.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RJD_C_SAMC803_0
(CARBOXY METHYL
TRANSFERASE FOR
PROTEIN PHOSPHATASE
2A CATALYTIC SUBUNIT)		 5n5n TUBULIN BETA CHAIN
(Homo
sapiens) 		5 / 12 ALA B  99
GLY B 150
GLY B 148
SER B 190
LEU B 137
 G2P  B 501 ( 4.6A)
None
None
None
None
 0.97A 1rjdC-5n5nB:
undetectable		 1rjdC-5n5nB:
22.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T7I_A_017A200_1
(POL POLYPROTEIN)		 5n5n TUBULIN BETA CHAIN
(Homo
sapiens) 		5 / 10 GLY B  10
ALA B   9
GLY B  17
ILE B  16
THR B 168
 G2P  B 501 ( 3.7A)
None
None
None
None
 1.01A 1t7iA-5n5nB:
undetectable		 1t7iA-5n5nB:
12.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AOJ_C_FRDC305_1
(POL POLYPROTEIN
PEPTIDE INHIBITOR)		 1w5f CELL DIVISION
PROTEIN FTSZ
(Thermotoga
maritima) 		4 / 5 LEU A  93
GLY A 118
PRO A 125
VAL A 126
 None
G2P  A 500 (-3.4A)
None
None
 0.82A 2aojA-1w5fA:
undetectable		 2aojA-1w5fA:
16.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AOJ_C_FRDC305_2
(POL POLYPROTEIN
PEPTIDE INHIBITOR)		 1w5f CELL DIVISION
PROTEIN FTSZ
(Thermotoga
maritima) 		4 / 7 LEU A  93
GLY A 118
PRO A 125
VAL A 126
 None
G2P  A 500 (-3.4A)
None
None
 0.78A 2aojB-1w5fA:
undetectable		 2aojB-1w5fA:
16.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2C49_A_ADNA1301_1
(SUGAR KINASE MJ0406)		 1w5f CELL DIVISION
PROTEIN FTSZ
(Thermotoga
maritima) 		5 / 12 ALA A  32
GLY A  30
GLY A  31
ASN A  54
ASP A  56
 G2P  A 500 (-3.3A)
G2P  A 500 (-3.5A)
G2P  A 500 (-3.1A)
MG  A 501 ( 4.5A)
None
 1.02A 2c49A-1w5fA:
7.9		 2c49A-1w5fA:
24.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DOU_A_SAMA1_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE J)		 1w5f CELL DIVISION
PROTEIN FTSZ
(Thermotoga
maritima) 		5 / 12 PRO A  85
GLY A 118
GLY A 117
LEU A  93
ILE A  99
 None
G2P  A 500 (-3.4A)
G2P  A 500 (-3.6A)
None
None
 0.97A 3douA-1w5fA:
4.8		 3douA-1w5fA:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FPJ_A_SAMA301_1
(PUTATIVE
UNCHARACTERIZED
PROTEIN)		 2bz0 GTP CYCLOHYDROLASE
II
(Escherichia
coli) 		4 / 6 GLY A  93
THR A 114
GLU A  92
GLU A  53
 G2P  A1176 (-3.4A)
G2P  A1176 (-2.9A)
G2P  A1176 (-4.3A)
None
 0.99A 3fpjA-2bz0A:
undetectable		 3fpjA-2bz0A:
23.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ONN_A_ACTA271_0
(PROTEIN SSM1)		 1w5f CELL DIVISION
PROTEIN FTSZ
(Thermotoga
maritima) 		4 / 5 GLY A 116
GLU A 149
GLY A 114
PRO A 145
 G2P  A 500 ( 4.4A)
G2P  A 500 (-2.7A)
G2P  A 500 (-3.5A)
G2P  A 500 (-4.3A)
 1.03A 3onnA-1w5fA:
6.6		 3onnA-1w5fA:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UBO_A_ADNA353_1
(ADENOSINE KINASE)		 1w5f CELL DIVISION
PROTEIN FTSZ
(Thermotoga
maritima) 		5 / 12 GLY A  30
GLY A  31
ASN A  54
GLY A  80
ASP A  56
 G2P  A 500 (-3.5A)
G2P  A 500 (-3.1A)
MG  A 501 ( 4.5A)
G2P  A 500 ( 3.7A)
None
 0.98A 3uboA-1w5fA:
8.1		 3uboA-1w5fA:
24.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AC9_C_DXCC1477_0
(MJ0495-LIKE PROTEIN)		 1w5f CELL DIVISION
PROTEIN FTSZ
(Thermotoga
maritima) 		4 / 6 THR A 119
GLY A  88
ILE A  75
LYS A  98
 G2P  A 500 (-3.6A)
None
None
None
 1.08A 4ac9C-1w5fA:
5.7		 4ac9C-1w5fA:
24.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ACA_C_DXCC1477_0
(TRANSLATION
ELONGATION FACTOR
SELB)		 1w5f CELL DIVISION
PROTEIN FTSZ
(Thermotoga
maritima) 		4 / 6 THR A 119
GLY A  88
ILE A  75
LYS A  98
 G2P  A 500 (-3.6A)
None
None
None
 1.05A 4acaC-1w5fA:
5.8		 4acaC-1w5fA:
24.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C5L_A_UEGA300_1
(PHOSPHOMETHYLPYRIMID
INE KINASE)		 1w5f CELL DIVISION
PROTEIN FTSZ
(Thermotoga
maritima) 		5 / 11 GLY A 120
ALA A  91
GLY A  88
VAL A  53
VAL A 126
 G2P  A 500 (-3.4A)
None
None
None
None
 1.32A 4c5lA-1w5fA:
2.9		 4c5lA-1w5fA:
24.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C5L_B_PXLB300_1
(PHOSPHOMETHYLPYRIMID
INE KINASE)		 1w5f CELL DIVISION
PROTEIN FTSZ
(Thermotoga
maritima) 		5 / 9 GLY A 120
ALA A  91
GLY A  88
VAL A  53
VAL A 126
 G2P  A 500 (-3.4A)
None
None
None
None
 1.27A 4c5lB-1w5fA:
3.0		 4c5lB-1w5fA:
24.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C5L_C_UEGC300_1
(PHOSPHOMETHYLPYRIMID
INE KINASE)		 1w5f CELL DIVISION
PROTEIN FTSZ
(Thermotoga
maritima) 		5 / 10 GLY A 120
ALA A  91
GLY A  88
VAL A  53
VAL A 126
 G2P  A 500 (-3.4A)
None
None
None
None
 1.30A 4c5lC-1w5fA:
3.1		 4c5lC-1w5fA:
24.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C5L_D_UEGD300_1
(PHOSPHOMETHYLPYRIMID
INE KINASE)		 1w5f CELL DIVISION
PROTEIN FTSZ
(Thermotoga
maritima) 		5 / 10 GLY A 120
ALA A  91
GLY A  88
VAL A  53
VAL A 126
 G2P  A 500 (-3.4A)
None
None
None
None
 1.30A 4c5lD-1w5fA:
3.0		 4c5lD-1w5fA:
24.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C5N_B_PXLB300_1
(PHOSPHOMETHYLPYRIMID
INE KINASE)		 1w5f CELL DIVISION
PROTEIN FTSZ
(Thermotoga
maritima) 		5 / 10 GLY A 120
ALA A  91
GLY A  88
VAL A  53
VAL A 126
 G2P  A 500 (-3.4A)
None
None
None
None
 1.28A 4c5nB-1w5fA:
3.2		 4c5nB-1w5fA:
24.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NJT_B_017B101_2
(PROTEASE)		 5n5n TUBULIN BETA CHAIN
(Homo
sapiens) 		5 / 10 GLY B  10
ALA B   9
GLY B  17
ILE B  16
THR B 168
 G2P  B 501 ( 3.7A)
None
None
None
None
 0.98A 4njtB-5n5nB:
undetectable		 4njtB-5n5nB:
14.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O3F_A_TZNA501_1
(PHOSPHOGLYCERATE
KINASE 1)		 1w5f CELL DIVISION
PROTEIN FTSZ
(Thermotoga
maritima) 		5 / 12 GLY A  33
ALA A  32
GLY A  30
GLY A  31
GLY A 120
 None
G2P  A 500 (-3.3A)
G2P  A 500 (-3.5A)
G2P  A 500 (-3.1A)
G2P  A 500 (-3.4A)
 0.86A 4o3fA-1w5fA:
5.0		 4o3fA-1w5fA:
25.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZJL_A_ERYA1101_0
(MULTIDRUG EFFLUX
PUMP SUBUNIT ACRB)		 5n5n TUBULIN BETA CHAIN
(Homo
sapiens) 		5 / 12 SER B 178
GLU B 183
GLU B  71
THR B 145
GLY B 144
 None
None
None
G2P  B 501 (-3.2A)
G2P  B 501 ( 4.6A)
 1.24A 4zjlA-5n5nB:
undetectable		 4zjlA-5n5nB:
17.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5D0X_K_BO2K301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 1w5f CELL DIVISION
PROTEIN FTSZ
(Thermotoga
maritima) 		5 / 9 SER A 124
GLY A  30
GLY A  31
ALA A  32
ASP A 197
 None
G2P  A 500 (-3.5A)
G2P  A 500 (-3.1A)
G2P  A 500 (-3.3A)
G2P  A 500 (-3.2A)
 1.03A 5d0xK-1w5fA:
undetectable
5d0xL-1w5fA:
undetectable		 5d0xK-1w5fA:
19.49
5d0xL-1w5fA:
20.34