SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'G24'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1BRP_A_RTLA183_0
(RETINOL BINDING
PROTEIN)		 1q4x THYROID HORMONE
RECEPTOR BETA-1
(Homo
sapiens) 		5 / 12 LEU A 341
PHE A 455
PHE A 459
MET A 310
HIS A 435
 None
G24  A 462 (-3.8A)
None
G24  A 462 ( 3.8A)
G24  A 462 (-3.9A)
 1.38A 1brpA-1q4xA:
undetectable		 1brpA-1q4xA:
18.97
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1BSX_A_T3A1_1
(PROTEIN (THYROID
HORMONE RECEPTOR
BETA))		 1q4x THYROID HORMONE
RECEPTOR BETA-1
(Homo
sapiens) 		11 / 12 ILE A 275
ILE A 276
ARG A 282
MET A 310
MET A 313
ALA A 317
LEU A 330
LEU A 346
ILE A 353
HIS A 435
PHE A 455
 None
G24  A 462 ( 4.3A)
G24  A 462 ( 3.9A)
G24  A 462 ( 3.8A)
G24  A 462 ( 4.6A)
G24  A 462 ( 4.1A)
G24  A 462 ( 3.9A)
G24  A 462 (-4.0A)
None
G24  A 462 (-3.9A)
G24  A 462 (-3.8A)
 0.60A 1bsxA-1q4xA:
36.7		 1bsxA-1q4xA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1BSX_B_T3B2_1
(PROTEIN (THYROID
HORMONE RECEPTOR
BETA))		 1q4x THYROID HORMONE
RECEPTOR BETA-1
(Homo
sapiens) 		11 / 12 ILE A 275
ILE A 276
ARG A 282
MET A 310
MET A 313
ALA A 317
LEU A 330
LEU A 346
ILE A 353
HIS A 435
PHE A 455
 None
G24  A 462 ( 4.3A)
G24  A 462 ( 3.9A)
G24  A 462 ( 3.8A)
G24  A 462 ( 4.6A)
G24  A 462 ( 4.1A)
G24  A 462 ( 3.9A)
G24  A 462 (-4.0A)
None
G24  A 462 (-3.9A)
G24  A 462 (-3.8A)
 0.60A 1bsxB-1q4xA:
36.8		 1bsxB-1q4xA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1XZX_X_T3X500_1
(THYROID HORMONE
RECEPTOR BETA-1)		 1q4x THYROID HORMONE
RECEPTOR BETA-1
(Homo
sapiens) 		11 / 12 ILE A 275
ILE A 276
ALA A 279
ARG A 282
MET A 310
MET A 313
LEU A 330
LEU A 346
ILE A 353
HIS A 435
PHE A 455
 None
G24  A 462 ( 4.3A)
G24  A 462 (-3.5A)
G24  A 462 ( 3.9A)
G24  A 462 ( 3.8A)
G24  A 462 ( 4.6A)
G24  A 462 ( 3.9A)
G24  A 462 (-4.0A)
None
G24  A 462 (-3.9A)
G24  A 462 (-3.8A)
 0.57A 1xzxX-1q4xA:
37.5		 1xzxX-1q4xA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1XZX_X_T3X500_1
(THYROID HORMONE
RECEPTOR BETA-1)		 1q4x THYROID HORMONE
RECEPTOR BETA-1
(Homo
sapiens) 		7 / 12 ILE A 275
ILE A 276
ALA A 279
ARG A 282
MET A 313
LEU A 341
ILE A 353
 None
G24  A 462 ( 4.3A)
G24  A 462 (-3.5A)
G24  A 462 ( 3.9A)
G24  A 462 ( 4.6A)
None
None
 1.34A 1xzxX-1q4xA:
37.5		 1xzxX-1q4xA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1XZX_X_T3X500_2
(THYROID HORMONE
RECEPTOR BETA-1)		 1q4x THYROID HORMONE
RECEPTOR BETA-1
(Homo
sapiens) 		3 / 3 PHE A 272
ARG A 316
ASN A 331
 G24  A 462 (-4.9A)
None
None
 0.56A 1xzxX-1q4xA:
37.5		 1xzxX-1q4xA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1Y0X_X_T44X500_1
(THYROID HORMONE
RECEPTOR BETA-1)		 1q4x THYROID HORMONE
RECEPTOR BETA-1
(Homo
sapiens) 		11 / 12 ILE A 276
ALA A 279
ARG A 282
MET A 310
MET A 313
ARG A 320
LEU A 346
ILE A 353
HIS A 435
PHE A 455
PHE A 459
 G24  A 462 ( 4.3A)
G24  A 462 (-3.5A)
G24  A 462 ( 3.9A)
G24  A 462 ( 3.8A)
G24  A 462 ( 4.6A)
G24  A 462 (-4.2A)
G24  A 462 (-4.0A)
None
G24  A 462 (-3.9A)
G24  A 462 (-3.8A)
None
 0.57A 1y0xX-1q4xA:
37.5		 1y0xX-1q4xA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1Y0X_X_T44X500_1
(THYROID HORMONE
RECEPTOR BETA-1)		 1q4x THYROID HORMONE
RECEPTOR BETA-1
(Homo
sapiens) 		6 / 12 ILE A 276
ALA A 279
ARG A 282
MET A 313
LEU A 341
ILE A 353
 G24  A 462 ( 4.3A)
G24  A 462 (-3.5A)
G24  A 462 ( 3.9A)
G24  A 462 ( 4.6A)
None
None
 1.37A 1y0xX-1q4xA:
37.5		 1y0xX-1q4xA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1Y0X_X_T44X500_2
(THYROID HORMONE
RECEPTOR BETA-1)		 1q4x THYROID HORMONE
RECEPTOR BETA-1
(Homo
sapiens) 		5 / 5 ILE A 275
SER A 314
ARG A 316
LEU A 330
ASN A 331
 None
G24  A 462 ( 4.7A)
None
G24  A 462 ( 3.9A)
None
 0.53A 1y0xX-1q4xA:
37.5		 1y0xX-1q4xA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2H77_A_T3A1_1
(THRA PROTEIN)		 1q4x THYROID HORMONE
RECEPTOR BETA-1
(Homo
sapiens) 		11 / 12 ILE A 276
ALA A 279
ARG A 282
MET A 310
MET A 313
ALA A 317
LEU A 330
LEU A 346
ILE A 353
HIS A 435
PHE A 455
 G24  A 462 ( 4.3A)
G24  A 462 (-3.5A)
G24  A 462 ( 3.9A)
G24  A 462 ( 3.8A)
G24  A 462 ( 4.6A)
G24  A 462 ( 4.1A)
G24  A 462 ( 3.9A)
G24  A 462 (-4.0A)
None
G24  A 462 (-3.9A)
G24  A 462 (-3.8A)
 0.47A 2h77A-1q4xA:
37.1		 2h77A-1q4xA:
81.06
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2H77_A_T3A1_1
(THRA PROTEIN)		 1q4x THYROID HORMONE
RECEPTOR BETA-1
(Homo
sapiens) 		7 / 12 ILE A 276
ALA A 279
ARG A 282
MET A 313
ALA A 317
LEU A 341
ILE A 353
 G24  A 462 ( 4.3A)
G24  A 462 (-3.5A)
G24  A 462 ( 3.9A)
G24  A 462 ( 4.6A)
G24  A 462 ( 4.1A)
None
None
 1.41A 2h77A-1q4xA:
37.1		 2h77A-1q4xA:
81.06
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2H79_A_T3A1_1
(THRA PROTEIN)		 1q4x THYROID HORMONE
RECEPTOR BETA-1
(Homo
sapiens) 		11 / 12 ILE A 275
ILE A 276
ALA A 279
ARG A 282
MET A 310
ALA A 317
LEU A 330
LEU A 346
ILE A 353
HIS A 435
PHE A 455
 None
G24  A 462 ( 4.3A)
G24  A 462 (-3.5A)
G24  A 462 ( 3.9A)
G24  A 462 ( 3.8A)
G24  A 462 ( 4.1A)
G24  A 462 ( 3.9A)
G24  A 462 (-4.0A)
None
G24  A 462 (-3.9A)
G24  A 462 (-3.8A)
 0.56A 2h79A-1q4xA:
36.5		 2h79A-1q4xA:
81.06
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2H79_A_T3A1_1
(THRA PROTEIN)		 1q4x THYROID HORMONE
RECEPTOR BETA-1
(Homo
sapiens) 		6 / 12 ILE A 276
ALA A 279
ARG A 282
ALA A 317
LEU A 341
ILE A 353
 G24  A 462 ( 4.3A)
G24  A 462 (-3.5A)
G24  A 462 ( 3.9A)
G24  A 462 ( 4.1A)
None
None
 1.42A 2h79A-1q4xA:
36.5		 2h79A-1q4xA:
81.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ADX_B_IMNB3_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 1q4x THYROID HORMONE
RECEPTOR BETA-1
(Homo
sapiens) 		5 / 12 SER A 314
ALA A 317
ILE A 353
LEU A 346
ILE A 276
 G24  A 462 ( 4.7A)
G24  A 462 ( 4.1A)
None
G24  A 462 (-4.0A)
G24  A 462 ( 4.3A)
 0.91A 3adxB-1q4xA:
21.4		 3adxB-1q4xA:
27.53
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3GWS_X_T3X500_1
(THYROID HORMONE
RECEPTOR BETA)		 1q4x THYROID HORMONE
RECEPTOR BETA-1
(Homo
sapiens) 		12 / 12 ILE A 275
ILE A 276
ALA A 279
ARG A 282
MET A 310
MET A 313
ALA A 317
LEU A 330
LEU A 346
ILE A 353
HIS A 435
PHE A 455
 None
G24  A 462 ( 4.3A)
G24  A 462 (-3.5A)
G24  A 462 ( 3.9A)
G24  A 462 ( 3.8A)
G24  A 462 ( 4.6A)
G24  A 462 ( 4.1A)
G24  A 462 ( 3.9A)
G24  A 462 (-4.0A)
None
G24  A 462 (-3.9A)
G24  A 462 (-3.8A)
 0.49A 3gwsX-1q4xA:
37.5		 3gwsX-1q4xA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3GWS_X_T3X500_1
(THYROID HORMONE
RECEPTOR BETA)		 1q4x THYROID HORMONE
RECEPTOR BETA-1
(Homo
sapiens) 		8 / 12 ILE A 275
ILE A 276
ALA A 279
ARG A 282
MET A 313
ALA A 317
LEU A 341
ILE A 353
 None
G24  A 462 ( 4.3A)
G24  A 462 (-3.5A)
G24  A 462 ( 3.9A)
G24  A 462 ( 4.6A)
G24  A 462 ( 4.1A)
None
None
 1.30A 3gwsX-1q4xA:
37.5		 3gwsX-1q4xA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R2C_A_ACTA153_0
(N UTILIZATION
SUBSTANCE PROTEIN B)		 1q4x THYROID HORMONE
RECEPTOR BETA-1
(Homo
sapiens) 		4 / 4 ASN A 331
GLY A 332
GLU A 333
LYS A 242
 None
G24  A 462 (-4.8A)
None
None
 1.27A 3r2cA-1q4xA:
1.9		 3r2cA-1q4xA:
20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TZF_B_08DB280_1
(7,8-DIHYDROPTEROATE
SYNTHASE)		 1q4x THYROID HORMONE
RECEPTOR BETA-1
(Homo
sapiens) 		4 / 8 PHE A 455
THR A 273
GLY A 345
PHE A 269
 G24  A 462 (-3.8A)
G24  A 462 (-4.5A)
G24  A 462 ( 4.1A)
G24  A 462 (-4.2A)
 1.05A 3tzfB-1q4xA:
undetectable		 3tzfB-1q4xA:
21.93
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3UVV_A_T3A501_1
(THYROID HORMONE
RECEPTOR ALPHA)		 1q4x THYROID HORMONE
RECEPTOR BETA-1
(Homo
sapiens) 		11 / 12 ILE A 275
ILE A 276
ALA A 279
MET A 310
ALA A 317
LEU A 330
LEU A 341
LEU A 346
ILE A 353
HIS A 435
PHE A 455
 None
G24  A 462 ( 4.3A)
G24  A 462 (-3.5A)
G24  A 462 ( 3.8A)
G24  A 462 ( 4.1A)
G24  A 462 ( 3.9A)
None
G24  A 462 (-4.0A)
None
G24  A 462 (-3.9A)
G24  A 462 (-3.8A)
 0.42A 3uvvA-1q4xA:
36.8		 3uvvA-1q4xA:
83.97
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4LNW_A_T3A501_1
(THYROID HORMONE
RECEPTOR ALPHA)		 1q4x THYROID HORMONE
RECEPTOR BETA-1
(Homo
sapiens) 		6 / 12 ILE A 276
ALA A 279
ARG A 282
ALA A 317
LEU A 341
ILE A 353
 G24  A 462 ( 4.3A)
G24  A 462 (-3.5A)
G24  A 462 ( 3.9A)
G24  A 462 ( 4.1A)
None
None
 1.35A 4lnwA-1q4xA:
36.7		 4lnwA-1q4xA:
81.44
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4LNW_A_T3A501_1
(THYROID HORMONE
RECEPTOR ALPHA)		 1q4x THYROID HORMONE
RECEPTOR BETA-1
(Homo
sapiens) 		10 / 12 ILE A 276
ALA A 279
ARG A 282
MET A 310
ALA A 317
LEU A 330
LEU A 346
ILE A 353
HIS A 435
PHE A 455
 G24  A 462 ( 4.3A)
G24  A 462 (-3.5A)
G24  A 462 ( 3.9A)
G24  A 462 ( 3.8A)
G24  A 462 ( 4.1A)
G24  A 462 ( 3.9A)
G24  A 462 (-4.0A)
None
G24  A 462 (-3.9A)
G24  A 462 (-3.8A)
 0.52A 4lnwA-1q4xA:
36.7		 4lnwA-1q4xA:
81.44
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4LNW_A_T3A501_2
(THYROID HORMONE
RECEPTOR ALPHA)		 1q4x THYROID HORMONE
RECEPTOR BETA-1
(Homo
sapiens) 		3 / 3 ILE A 275
MET A 313
ARG A 316
 None
G24  A 462 ( 4.6A)
None
 0.39A 4lnwA-1q4xA:
36.7		 4lnwA-1q4xA:
81.44
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4LNX_A_T3A502_1
(THYROID HORMONE
RECEPTOR ALPHA)		 1q4x THYROID HORMONE
RECEPTOR BETA-1
(Homo
sapiens) 		6 / 12 ILE A 276
ALA A 279
ARG A 282
ALA A 317
LEU A 341
ILE A 353
 G24  A 462 ( 4.3A)
G24  A 462 (-3.5A)
G24  A 462 ( 3.9A)
G24  A 462 ( 4.1A)
None
None
 1.39A 4lnxA-1q4xA:
36.8		 4lnxA-1q4xA:
81.44
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4LNX_A_T3A502_1
(THYROID HORMONE
RECEPTOR ALPHA)		 1q4x THYROID HORMONE
RECEPTOR BETA-1
(Homo
sapiens) 		10 / 12 ILE A 276
ALA A 279
ARG A 282
MET A 310
ALA A 317
LEU A 330
LEU A 346
ILE A 353
HIS A 435
PHE A 455
 G24  A 462 ( 4.3A)
G24  A 462 (-3.5A)
G24  A 462 ( 3.9A)
G24  A 462 ( 3.8A)
G24  A 462 ( 4.1A)
G24  A 462 ( 3.9A)
G24  A 462 (-4.0A)
None
G24  A 462 (-3.9A)
G24  A 462 (-3.8A)
 0.50A 4lnxA-1q4xA:
36.8		 4lnxA-1q4xA:
81.44
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4LNX_A_T3A502_2
(THYROID HORMONE
RECEPTOR ALPHA)		 1q4x THYROID HORMONE
RECEPTOR BETA-1
(Homo
sapiens) 		3 / 3 ILE A 275
MET A 313
ARG A 316
 None
G24  A 462 ( 4.6A)
None
 0.36A 4lnxA-1q4xA:
36.8		 4lnxA-1q4xA:
81.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RZV_A_032A801_2
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 1q4x THYROID HORMONE
RECEPTOR BETA-1
(Homo
sapiens) 		4 / 5 ILE A 431
VAL A 349
PHE A 451
CYH A 309
 None
None
G24  A 462 (-4.7A)
None
 1.27A 4rzvA-1q4xA:
undetectable		 4rzvA-1q4xA:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XTA_A_DIFA501_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 1q4x THYROID HORMONE
RECEPTOR BETA-1
(Homo
sapiens) 		4 / 9 SER A 314
ALA A 317
LEU A 341
ILE A 276
 G24  A 462 ( 4.7A)
G24  A 462 ( 4.1A)
None
G24  A 462 ( 4.3A)
 0.89A 4xtaA-1q4xA:
23.2		 4xtaA-1q4xA:
28.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XTA_A_DIFA501_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 1q4x THYROID HORMONE
RECEPTOR BETA-1
(Homo
sapiens) 		4 / 9 SER A 314
ALA A 317
LEU A 346
ILE A 276
 G24  A 462 ( 4.7A)
G24  A 462 ( 4.1A)
G24  A 462 (-4.0A)
G24  A 462 ( 4.3A)
 0.97A 4xtaA-1q4xA:
23.2		 4xtaA-1q4xA:
28.17
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ZO1_X_T3X500_1
(THYROID HORMONE
RECEPTOR BETA)		 1q4x THYROID HORMONE
RECEPTOR BETA-1
(Homo
sapiens) 		11 / 12 ILE A 276
ALA A 279
ARG A 282
MET A 310
MET A 313
ALA A 317
ARG A 320
LEU A 330
ASN A 331
HIS A 435
PHE A 455
 G24  A 462 ( 4.3A)
G24  A 462 (-3.5A)
G24  A 462 ( 3.9A)
G24  A 462 ( 3.8A)
G24  A 462 ( 4.6A)
G24  A 462 ( 4.1A)
G24  A 462 (-4.2A)
G24  A 462 ( 3.9A)
None
G24  A 462 (-3.9A)
G24  A 462 (-3.8A)
 0.59A 4zo1X-1q4xA:
37.5		 4zo1X-1q4xA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_U_BEZU801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2
BEZ-LEU-LEU)		 1q4x THYROID HORMONE
RECEPTOR BETA-1
(Homo
sapiens) 		4 / 6 PHE A 354
SER A 314
ALA A 317
LEU A 356
 None
G24  A 462 ( 4.7A)
G24  A 462 ( 4.1A)
None
 1.27A 5dzkg-1q4xA:
undetectable
5dzku-1q4xA:
undetectable		 5dzkg-1q4xA:
21.25
5dzku-1q4xA:
1.21