SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'G1P'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MXF_D_MTXD4278_1
(PTERIDINE REDUCTASE
2)		 6gh2 LAMINARIBIOSE
PHOSPHORYLASE
(Paenibacillus
sp.
YM1) 		5 / 11 ARG A 374
TYR A 544
LEU A 519
THR A 671
TYR A 652
 G1P  A1002 (-3.9A)
None
None
None
None
 1.49A 1mxfD-6gh2A:
undetectable		 1mxfD-6gh2A:
12.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1R15_C_NCAC339_0
(ADP-RIBOSYL CYCLASE)		 6gh2 LAMINARIBIOSE
PHOSPHORYLASE
(Paenibacillus
sp.
YM1) 		3 / 3 GLU A 732
ASN A 525
TRP A 524
 G1P  A1002 (-3.7A)
None
G1P  A1002 (-3.3A)
 1.08A 1r15C-6gh2A:
undetectable		 1r15C-6gh2A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1R15_D_NCAD349_0
(ADP-RIBOSYL CYCLASE)		 6gh2 LAMINARIBIOSE
PHOSPHORYLASE
(Paenibacillus
sp.
YM1) 		3 / 3 GLU A 732
ASN A 525
TRP A 524
 G1P  A1002 (-3.7A)
None
G1P  A1002 (-3.3A)
 1.08A 1r15D-6gh2A:
undetectable		 1r15D-6gh2A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1R15_E_NCAE359_0
(ADP-RIBOSYL CYCLASE)		 6gh2 LAMINARIBIOSE
PHOSPHORYLASE
(Paenibacillus
sp.
YM1) 		3 / 3 GLU A 732
ASN A 525
TRP A 524
 G1P  A1002 (-3.7A)
None
G1P  A1002 (-3.3A)
 1.09A 1r15E-6gh2A:
undetectable		 1r15E-6gh2A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1R15_F_NCAF369_0
(ADP-RIBOSYL CYCLASE)		 6gh2 LAMINARIBIOSE
PHOSPHORYLASE
(Paenibacillus
sp.
YM1) 		3 / 3 GLU A 732
ASN A 525
TRP A 524
 G1P  A1002 (-3.7A)
None
G1P  A1002 (-3.3A)
 1.05A 1r15F-6gh2A:
undetectable		 1r15F-6gh2A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EJF_A_ADNA2001_1
(235AA LONG
HYPOTHETICAL
BIOTIN--[ACETYL-COA-
CARBOXYLASE] LIGASE)		 1uxt GLYCERALDEHYDE-3-PHO
SPHATE DEHYDROGENASE
(NADP+)
(Thermoproteus
tenax) 		4 / 7 ARG A  72
ALA A 187
PRO A 213
ALA A 216
 G1P  A1502 (-3.3A)
None
None
None
 0.95A 2ejfA-1uxtA:
undetectable		 2ejfA-1uxtA:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HZQ_A_STRA300_1
(APOLIPOPROTEIN D)		 4ho4 GLUCOSE-1-PHOSPHATE
THYMIDYLYLTRANSFERAS
E
(Aneurinibacillus
thermoaerophilus) 		4 / 7 THR A 224
TYR A 174
PHE A 111
LEU A  86
 None
None
None
G1P  A 301 ( 4.9A)
 1.03A 2hzqA-4ho4A:
undetectable		 2hzqA-4ho4A:
18.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OPX_A_DXCA1003_0
(ALDEHYDE
DEHYDROGENASE A)		 5h42 UNCHARACTERIZED
PROTEIN
(Lachnoclostridiu
m
phytofermentans) 		4 / 5 ILE A 850
LEU A 841
ASP A 759
ALA A 895
 None
None
G1P  A1201 (-4.5A)
None
 1.01A 2opxA-5h42A:
undetectable		 2opxA-5h42A:
17.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QEB_A_HSMA145_1
(D7R4 PROTEIN)		 1nt4 GLUCOSE-1-PHOSPHATAS
E
(Escherichia
coli) 		4 / 7 ILE A 293
ARG A  17
TYR A 305
GLU A 312
 None
G1P  A2000 (-4.0A)
None
None
 1.05A 2qebA-1nt4A:
undetectable		 2qebA-1nt4A:
16.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QEB_B_HSMB145_1
(D7R4 PROTEIN)		 1nt4 GLUCOSE-1-PHOSPHATAS
E
(Escherichia
coli) 		4 / 7 ILE A 293
ARG A  17
TYR A 305
GLU A 312
 None
G1P  A2000 (-4.0A)
None
None
 1.08A 2qebB-1nt4A:
undetectable		 2qebB-1nt4A:
16.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QEO_A_LNRA200_1
(D7R4 PROTEIN)		 2ux8 GLUCOSE-1-PHOSPHATE
URIDYLYLTRANSFERASE
(Sphingomonas
elodea) 		5 / 12 GLU A 161
ARG A 253
ILE A 158
TYR A 208
ASP A 255
 None
G1P  A1290 ( 4.4A)
None
None
G1P  A1290 ( 4.7A)
 1.40A 2qeoA-2ux8A:
undetectable		 2qeoA-2ux8A:
19.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QEO_B_LNRB200_1
(D7R4 PROTEIN)		 2ux8 GLUCOSE-1-PHOSPHATE
URIDYLYLTRANSFERASE
(Sphingomonas
elodea) 		5 / 10 GLU A 161
ARG A 253
ILE A 158
TYR A 208
ASP A 255
 None
G1P  A1290 ( 4.4A)
None
None
G1P  A1290 ( 4.7A)
 1.40A 2qeoB-2ux8A:
undetectable		 2qeoB-2ux8A:
19.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QO4_A_CHDA130_0
(LIVER-BASIC FATTY
ACID BINDING PROTEIN)		 5h42 UNCHARACTERIZED
PROTEIN
(Lachnoclostridiu
m
phytofermentans) 		5 / 12 LEU A 855
ALA A 925
THR A 761
HIS A 684
ARG A 630
 None
None
None
None
G1P  A1201 (-3.9A)
 1.31A 2qo4A-5h42A:
1.7		 2qo4A-5h42A:
8.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y05_A_RALA801_1
(PROSTAGLANDIN
REDUCTASE 1)		 6gh2 LAMINARIBIOSE
PHOSPHORYLASE
(Paenibacillus
sp.
YM1) 		4 / 8 ARG A 374
TYR A 544
VAL A 402
TYR A 399
 G1P  A1002 (-3.9A)
None
None
None
 1.33A 2y05A-6gh2A:
undetectable
2y05B-6gh2A:
undetectable		 2y05A-6gh2A:
13.46
2y05B-6gh2A:
13.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K37_A_BCZA468_1
(NEURAMINIDASE)		 2ux8 GLUCOSE-1-PHOSPHATE
URIDYLYLTRANSFERASE
(Sphingomonas
elodea) 		3 / 3 ASP A 134
ARG A 207
ARG A  19
 G1P  A1290 (-3.5A)
None
G1P  A1290 ( 4.9A)
 1.03A 3k37A-2ux8A:
undetectable		 3k37A-2ux8A:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RAE_H_LFXH101_1
(DNA TOPOISOMERASE 4
SUBUNIT A
DNA TOPOISOMERASE 4
SUBUNIT B)		 4ho4 GLUCOSE-1-PHOSPHATE
THYMIDYLYLTRANSFERAS
E
(Aneurinibacillus
thermoaerophilus) 		4 / 5 SER A  53
GLY A  85
GLU A 159
GLU A 196
 None
THM  A 302 (-3.6A)
G1P  A 301 (-2.8A)
None
 1.39A 3raeB-4ho4A:
undetectable
3raeD-4ho4A:
undetectable		 3raeB-4ho4A:
22.63
3raeD-4ho4A:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U7S_A_017A202_1
(POL POLYPROTEIN)		 4ho4 GLUCOSE-1-PHOSPHATE
THYMIDYLYLTRANSFERAS
E
(Aneurinibacillus
thermoaerophilus) 		5 / 9 ALA A 184
ILE A  97
GLY A  93
ILE A  92
LEU A  86
 None
None
None
None
G1P  A 301 ( 4.9A)
 1.08A 3u7sA-4ho4A:
undetectable		 3u7sA-4ho4A:
16.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WDM_C_ADNC301_1
(4-PHOSPHOPANTOATE--B
ETA-ALANINE LIGASE)		 4ho4 GLUCOSE-1-PHOSPHATE
THYMIDYLYLTRANSFERAS
E
(Aneurinibacillus
thermoaerophilus) 		5 / 9 GLY A 172
LEU A  41
ASP A 108
LEU A 106
ILE A   5
 G1P  A 301 ( 4.2A)
None
THM  A 302 (-3.5A)
THM  A 302 (-4.2A)
None
 1.22A 3wdmC-4ho4A:
undetectable		 3wdmC-4ho4A:
24.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WDM_D_ADND301_1
(4-PHOSPHOPANTOATE--B
ETA-ALANINE LIGASE)		 4ho4 GLUCOSE-1-PHOSPHATE
THYMIDYLYLTRANSFERAS
E
(Aneurinibacillus
thermoaerophilus) 		5 / 10 GLY A 172
LEU A  41
ASP A 108
LEU A 106
ILE A   5
 G1P  A 301 ( 4.2A)
None
THM  A 302 (-3.5A)
THM  A 302 (-4.2A)
None
 1.17A 3wdmD-4ho4A:
undetectable		 3wdmD-4ho4A:
24.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AZS_A_SAMA1475_1
(METHYLTRANSFERASE
WBDD)		 5h42 UNCHARACTERIZED
PROTEIN
(Lachnoclostridiu
m
phytofermentans) 		3 / 3 ARG A 907
ASP A 631
GLN A 634
 None
G1P  A1201 (-2.8A)
None
 0.75A 4azsA-5h42A:
undetectable		 4azsA-5h42A:
19.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FFW_A_715A801_1
(DIPEPTIDYL PEPTIDASE
4)		 5h42 UNCHARACTERIZED
PROTEIN
(Lachnoclostridiu
m
phytofermentans) 		5 / 12 ARG A 916
GLU A 917
GLY A 915
TYR A 969
SER A1005
 G1P  A1201 ( 4.0A)
G1P  A1201 (-3.6A)
None
None
G1P  A1201 (-2.5A)
 1.23A 4ffwA-5h42A:
undetectable		 4ffwA-5h42A:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FFW_B_715B801_1
(DIPEPTIDYL PEPTIDASE
4)		 5h42 UNCHARACTERIZED
PROTEIN
(Lachnoclostridiu
m
phytofermentans) 		5 / 12 ARG A 916
GLU A 917
GLY A 915
TYR A 969
SER A1005
 G1P  A1201 ( 4.0A)
G1P  A1201 (-3.6A)
None
None
G1P  A1201 (-2.5A)
 1.29A 4ffwB-5h42A:
undetectable		 4ffwB-5h42A:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IIL_A_RBFA401_1
(MEMBRANE LIPOPROTEIN
TPN38(B))		 5h42 UNCHARACTERIZED
PROTEIN
(Lachnoclostridiu
m
phytofermentans) 		5 / 12 SER A1005
GLN A 921
ILE A 601
GLY A1007
ASP A 608
 G1P  A1201 (-2.5A)
None
None
None
None
 0.96A 4iilA-5h42A:
undetectable		 4iilA-5h42A:
14.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IQB_A_KANA600_1
(BIFUNCTIONAL AAC/APH)		 2b0c PUTATIVE PHOSPHATASE
(Escherichia
coli) 		5 / 12 ASP A  13
SER A 114
ASP A 173
GLU A  55
GLU A 150
 G1P  A 496 (-2.2A)
G1P  A 496 (-2.6A)
G1P  A 496 (-2.4A)
None
None
 1.44A 5iqbA-2b0cA:
undetectable		 5iqbA-2b0cA:
20.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IQB_B_KANB600_1
(BIFUNCTIONAL AAC/APH)		 2b0c PUTATIVE PHOSPHATASE
(Escherichia
coli) 		5 / 11 ASP A  13
SER A 114
ASP A 173
GLU A  55
GLU A 150
 G1P  A 496 (-2.2A)
G1P  A 496 (-2.6A)
G1P  A 496 (-2.4A)
None
None
 1.44A 5iqbB-2b0cA:
0.0		 5iqbB-2b0cA:
20.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IQB_D_KAND600_1
(BIFUNCTIONAL AAC/APH)		 2b0c PUTATIVE PHOSPHATASE
(Escherichia
coli) 		5 / 12 ASP A  13
SER A 114
ASP A 173
GLU A  55
GLU A 150
 G1P  A 496 (-2.2A)
G1P  A 496 (-2.6A)
G1P  A 496 (-2.4A)
None
None
 1.44A 5iqbD-2b0cA:
undetectable		 5iqbD-2b0cA:
20.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5J7W_D_MTXD402_1
(THYMIDYLATE SYNTHASE)		 4ho4 GLUCOSE-1-PHOSPHATE
THYMIDYLYLTRANSFERAS
E
(Aneurinibacillus
thermoaerophilus) 		5 / 12 GLU A 159
LEU A 195
GLY A  85
ILE A 187
ALA A 184
 G1P  A 301 (-2.8A)
None
THM  A 302 (-3.6A)
None
None
 0.93A 5j7wD-4ho4A:
undetectable		 5j7wD-4ho4A:
23.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6D8F_A_ACTA803_0
(UNCHARACTERIZED
PROTEIN)		 5h42 UNCHARACTERIZED
PROTEIN
(Lachnoclostridiu
m
phytofermentans) 		3 / 3 GLU A 917
LEU A 890
ARG A 853
 G1P  A1201 (-3.6A)
None
None
 0.71A 6d8fA-5h42A:
undetectable		 6d8fA-5h42A:
21.37