SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'G1L'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MRL_A_DOLA300_1
(STREPTOGRAMIN A
ACETYLTRANSFERASE)		 2i80 D-ALANINE-D-ALANINE
LIGASE
(Staphylococcus
aureus) 		5 / 11 ILE A 105
LEU A 289
MET A 310
LEU A  94
ASN A 228
 None
G1L  A 400 (-4.0A)
G1L  A 400 (-4.0A)
G1L  A 400 (-4.3A)
None
 1.33A 1mrlA-2i80A:
undetectable
1mrlB-2i80A:
undetectable		 1mrlA-2i80A:
21.43
1mrlB-2i80A:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MRL_B_DOLB301_1
(STREPTOGRAMIN A
ACETYLTRANSFERASE)		 2i80 D-ALANINE-D-ALANINE
LIGASE
(Staphylococcus
aureus) 		5 / 12 ILE A 105
LEU A 289
MET A 310
LEU A  94
ASN A 228
 None
G1L  A 400 (-4.0A)
G1L  A 400 (-4.0A)
G1L  A 400 (-4.3A)
None
 1.44A 1mrlB-2i80A:
undetectable
1mrlC-2i80A:
undetectable		 1mrlB-2i80A:
21.43
1mrlC-2i80A:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ROX_B_T44B128_1
(TRANSTHYRETIN)		 2i80 D-ALANINE-D-ALANINE
LIGASE
(Staphylococcus
aureus) 		4 / 6 LEU A 289
ALA A 224
LEU A 226
THR A 234
 G1L  A 400 (-4.0A)
None
None
None
 1.01A 2roxB-2i80A:
undetectable		 2roxB-2i80A:
17.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VJ1_A_BEZA1303_0
(SARS CORONAVIRUS
MAIN PROTEINASE)		 2i80 D-ALANINE-D-ALANINE
LIGASE
(Staphylococcus
aureus) 		3 / 3 HIS A  96
MET A 128
MET A 310
 G1L  A 400 (-3.4A)
None
G1L  A 400 (-4.0A)
 1.02A 2vj1A-2i80A:
undetectable		 2vj1A-2i80A:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NQA_A_9CRA501_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 2i80 D-ALANINE-D-ALANINE
LIGASE
(Staphylococcus
aureus) 		5 / 11 ALA A 224
PHE A 281
ALA A 292
VAL A 117
LEU A 333
 None
None
None
G1L  A 400 (-4.0A)
None
 1.16A 4nqaA-2i80A:
undetectable		 4nqaA-2i80A:
23.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L8O_B_CHDB1001_0
(GASTROTROPIN)		 2i80 D-ALANINE-D-ALANINE
LIGASE
(Staphylococcus
aureus) 		5 / 12 ILE A 105
THR A 104
LEU A  94
VAL A   9
SER A  20
 None
None
G1L  A 400 (-4.3A)
None
G1L  A 400 (-4.2A)
 1.45A 5l8oB-2i80A:
0.0		 5l8oB-2i80A:
15.41