SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'G16'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_H_SVRH511_3
(PHOSPHOLIPASE A2)		 5kl0 PHOSPHOGLUCOMUTASE
(Xanthomonas
citri) 		4 / 7 ILE A 393
GLY A 391
ARG A 302
LEU A 303
 None
None
G16  A 501 ( 3.6A)
None
 0.93A 3bjwH-5kl0A:
undetectable		 3bjwH-5kl0A:
13.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BXO_A_SAMA238_1
(N,N-DIMETHYLTRANSFER
ASE)		 5kl0 PHOSPHOGLUCOMUTASE
(Xanthomonas
citri) 		3 / 3 TYR A 102
GLU A 342
ASP A 422
 None
G16  A 501 (-2.8A)
None
 0.78A 3bxoA-5kl0A:
undetectable		 3bxoA-5kl0A:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KK6_B_CELB1701_1
(PROSTAGLANDIN G/H
SYNTHASE 1)		 5kl0 PHOSPHOGLUCOMUTASE
(Xanthomonas
citri) 		5 / 12 HIS A 325
VAL A 114
LEU A 130
SER A 139
GLY A 127
 G16  A 501 (-4.0A)
None
None
None
None
 1.19A 3kk6B-5kl0A:
undetectable		 3kk6B-5kl0A:
20.62
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3LS4_H_TCIH220_1
(HEAVY CHAIN OF
ANTIBODY FAB
FRAGMENT)		 5vgj VRC38.01 FAB HEAVY
CHAIN
(Homo
sapiens) 		5 / 10 TRP H  47
SER H  50
TYR H  58
GLY H  95
TRP H 103
 None
None
MAN  G1563 (-3.9A)
MAN  G1606 (-4.1A)
None
 0.69A 3ls4H-5vgjH:
26.4		 3ls4H-5vgjH:
60.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TBG_A_RTZA1_1
(CYTOCHROME P450 2D6)		 5vgj 1FD6-V1V2-WITO
(Human
immunodeficiency
virus
1) 		5 / 12 LEU G 193
GLY G 240
LEU G 241
GLU G 239
PHE G 159
 None
NAG  G1600 (-3.9A)
None
None
None
 1.34A 3tbgA-5vgjG:
undetectable		 3tbgA-5vgjG:
14.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TBG_C_RTZC1_1
(CYTOCHROME P450 2D6)		 5vgj 1FD6-V1V2-WITO
(Human
immunodeficiency
virus
1) 		5 / 12 LEU G 193
GLY G 240
LEU G 241
GLU G 239
PHE G 159
 None
NAG  G1600 (-3.9A)
None
None
None
 1.34A 3tbgC-5vgjG:
undetectable		 3tbgC-5vgjG:
14.09