SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'FZZ'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZQ9_A_SAMA4000_0
(PROBABLE
DIMETHYLADENOSINE
TRANSFERASE)		 4zaa FDC1
(Aspergillus
niger) 		5 / 12 ILE A 171
GLY A 155
LEU A 211
ILE A  66
SER A  72
 FZZ  A 602 ( 3.7A)
None
None
None
None
 1.23A 1zq9A-4zaaA:
undetectable		 1zq9A-4zaaA:
19.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XZ5_C_ACHC1211_0
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 4zaa FDC1
(Aspergillus
niger) 		4 / 8 THR A 323
ASP A 321
SER A 314
TYR A 150
 FZZ  A 602 (-4.7A)
None
FZZ  A 602 ( 3.9A)
None
 1.36A 2xz5A-4zaaA:
undetectable
2xz5C-4zaaA:
undetectable		 2xz5A-4zaaA:
18.76
2xz5C-4zaaA:
18.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DL9_B_V2HB602_0
(CYTOCHROME P450 2R1)		 4zaa FDC1
(Aspergillus
niger) 		5 / 12 PHE A  10
VAL A 215
ALA A 212
ALA A 309
ILE A 171
 None
None
None
None
FZZ  A 602 ( 3.7A)
 1.16A 3dl9B-4zaaA:
undetectable		 3dl9B-4zaaA:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VRM_A_VD3A502_1
(VITAMIN D(3)
25-HYDROXYLASE)		 4zaa FDC1
(Aspergillus
niger) 		5 / 12 ILE A 192
LEU A 182
LEU A 269
ALA A 296
ILE A 171
 None
None
None
None
FZZ  A 602 ( 3.7A)
 1.06A 3vrmA-4zaaA:
undetectable		 3vrmA-4zaaA:
23.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QZU_C_RTLC201_1
(RETINOL-BINDING
PROTEIN 2)		 4zaa FDC1
(Aspergillus
niger) 		3 / 3 LYS A 391
TRP A 166
GLN A 194
 FZZ  A 602 ( 2.6A)
None
None
 1.07A 4qzuC-4zaaA:
0.0		 4qzuC-4zaaA:
14.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5H8T_A_RTLA201_1
(RETINOL-BINDING
PROTEIN 1)		 4zaa FDC1
(Aspergillus
niger) 		4 / 6 LEU A 330
LYS A 391
TRP A 166
GLN A 194
 None
FZZ  A 602 ( 2.6A)
None
None
 1.36A 5h8tA-4zaaA:
undetectable		 5h8tA-4zaaA:
15.05