SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'FZ4'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4A6D_A_SAMA1350_0 (HYDROXYINDOLE O-METHYLTRANSFERASE)	6d7t	TRANSIENT RECEPTOR POTENTIAL CATION CHANNEL SUBFAMILY V MEMBER 6 (Homo sapiens)	5 / 12	PHE A 487 LEU A 428 GLY A 423 ILE A 420 ALA A 467	None None FZ4 A 801 ( 4.0A) None FZ4 A 801 ( 4.2A)	1.07A	4a6dA-6d7tA: undetectable	4a6dA-6d7tA: undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4WH5_A_3QBA204_1 (LINCOSAMIDE RESISTANCE PROTEIN)	6d7t	TRANSIENT RECEPTOR POTENTIAL CATION CHANNEL SUBFAMILY V MEMBER 6 (Homo sapiens)	5 / 12	GLY A 422 HIS A 426 PHE A 468 PHE A 329 GLN A 596	None FZ4 A 801 ( 2.5A) None None None	1.41A	4wh5A-6d7tA: undetectable	4wh5A-6d7tA: undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5VEU_H_RITH602_2 (CYTOCHROME P450 3A5)	6d7t	TRANSIENT RECEPTOR POTENTIAL CATION CHANNEL SUBFAMILY V MEMBER 6 (Homo sapiens)	4 / 5	ARG A 470 PHE A 478 LEU A 475 LEU A 592	FZ4 A 801 ( 3.7A) None None None	1.36A	5veuH-6d7tA: undetectable	5veuH-6d7tA: undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5VLM_A_CVIA301_0 (REGULATORY PROTEIN TETR)	6d7t	TRANSIENT RECEPTOR POTENTIAL CATION CHANNEL SUBFAMILY V MEMBER 6 (Homo sapiens)	5 / 12	MET A 603 SER A 291 GLU A 282 LEU A 293 ILE A 296	FZ4 A 801 ( 3.5A) None None None None	1.27A	5vlmA-6d7tA: undetectable	5vlmA-6d7tA: undetectable

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["4A6D_A_SAMA1350_0","HYDROXYINDOLE O-METHYLTRANSFERASE","6d7t","TRANSIENT RECEPTOR POTENTIAL CATION CHANNEL SUBFAMILY V MEMBER 6","Homo sapiens",5,"PHE A 487;LEU A 428;GLY A 423;ILE A 420;ALA A 467","None;None;FZ4 A 801 ( 4.0A);None;FZ4 A 801 ( 4.2A)","1.07A","4a6dA-6d7tA:undetectable",null],["4WH5_A_3QBA204_1","LINCOSAMIDE RESISTANCE PROTEIN","6d7t","TRANSIENT RECEPTOR POTENTIAL CATION CHANNEL SUBFAMILY V MEMBER 6","Homo sapiens",5,"GLY A 422;HIS A 426;PHE A 468;PHE A 329;GLN A 596","None;FZ4 A 801 ( 2.5A);None;None;None","1.41A","4wh5A-6d7tA:undetectable","4a6dA-6d7tA:undetectable"],["5VEU_H_RITH602_2","CYTOCHROME P450 3A5","6d7t","TRANSIENT RECEPTOR POTENTIAL CATION CHANNEL SUBFAMILY V MEMBER 6","Homo sapiens",4,"ARG A 470;PHE A 478;LEU A 475;LEU A 592","FZ4 A 801 ( 3.7A);None;None;None","1.36A","5veuH-6d7tA:undetectable","4wh5A-6d7tA:undetectable"],["5VLM_A_CVIA301_0","REGULATORY PROTEIN TETR","6d7t","TRANSIENT RECEPTOR POTENTIAL CATION CHANNEL SUBFAMILY V MEMBER 6","Homo sapiens",5,"MET A 603;SER A 291;GLU A 282;LEU A 293;ILE A 296","FZ4 A 801 ( 3.5A);None;None;None;None","1.27A","5vlmA-6d7tA:undetectable","5veuH-6d7tA:undetectable"]]