SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'FXP'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JX4_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3zse ENDO-1,4-BETA-XYLANA
SE
(Thermobifida
fusca) 		4 / 6 VAL A  88
ARG A 161
TRP A  60
TRP A 120
 FXP  A1207 (-4.7A)
FXP  A1207 (-4.1A)
FXP  A1207 (-3.9A)
FXP  A1207 (-4.6A)
 1.48A 3jx4A-3zseA:
undetectable
3jx4B-3zseA:
undetectable		 3jx4A-3zseA:
17.36
3jx4B-3zseA:
17.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KU9_B_SPMB700_1
(POLYAMINE OXIDASE)		 3zse ENDO-1,4-BETA-XYLANA
SE
(Thermobifida
fusca) 		4 / 7 TYR A 129
TYR A 118
TYR A 210
TYR A  77
 None
FXP  A1207 (-4.7A)
FXP  A1207 (-4.7A)
None
 1.26A 3ku9B-3zseA:
undetectable		 3ku9B-3zseA:
16.39
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5TZO_A_7V7A201_1
(ENDO-1,4-BETA-XYLANA
SE A)		 3zse ENDO-1,4-BETA-XYLANA
SE
(Thermobifida
fusca) 		4 / 8 THR A 140
THR A 159
ARG A 161
GLN A 175
 None
None
FXP  A1207 (-4.1A)
FXP  A1207 (-4.3A)
 0.78A 5tzoA-3zseA:
28.4		 5tzoA-3zseA:
55.94
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5TZO_A_7V7A201_1
(ENDO-1,4-BETA-XYLANA
SE A)		 3zse ENDO-1,4-BETA-XYLANA
SE
(Thermobifida
fusca) 		5 / 8 TYR A 157
THR A 159
ARG A 161
GLN A 175
TRP A 177
 None
None
FXP  A1207 (-4.1A)
FXP  A1207 (-4.3A)
None
 0.48A 5tzoA-3zseA:
28.4		 5tzoA-3zseA:
55.94
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5TZO_A_7V7A202_1
(ENDO-1,4-BETA-XYLANA
SE A)		 3zse ENDO-1,4-BETA-XYLANA
SE
(Thermobifida
fusca) 		7 / 12 VAL A  88
TRP A 120
TYR A 129
PRO A 165
TRP A 177
TYR A 210
GLY A 217
 FXP  A1207 (-4.7A)
FXP  A1207 (-4.6A)
None
FXP  A1207 (-3.7A)
None
FXP  A1207 (-4.7A)
None
 0.78A 5tzoA-3zseA:
28.4		 5tzoA-3zseA:
55.94
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5TZO_B_7V7B201_1
(ENDO-1,4-BETA-XYLANA
SE A)		 3zse ENDO-1,4-BETA-XYLANA
SE
(Thermobifida
fusca) 		6 / 12 VAL A  88
TRP A 120
TYR A 129
TRP A 177
TYR A 210
GLY A 217
 FXP  A1207 (-4.7A)
FXP  A1207 (-4.6A)
None
None
FXP  A1207 (-4.7A)
None
 0.79A 5tzoB-3zseA:
28.6		 5tzoB-3zseA:
55.94
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5TZO_B_7V7B201_2
(ENDO-1,4-BETA-XYLANA
SE A)		 3zse ENDO-1,4-BETA-XYLANA
SE
(Thermobifida
fusca) 		3 / 3 ARG A 161
PRO A 165
TYR A 218
 FXP  A1207 (-4.1A)
FXP  A1207 (-3.7A)
EDO  A1232 (-3.8A)
 0.53A 5tzoB-3zseA:
28.6		 5tzoB-3zseA:
55.94
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5TZO_B_7V7B202_1
(ENDO-1,4-BETA-XYLANA
SE A)		 3zse ENDO-1,4-BETA-XYLANA
SE
(Thermobifida
fusca) 		4 / 8 THR A 140
THR A 159
ARG A 161
GLN A 175
 None
None
FXP  A1207 (-4.1A)
FXP  A1207 (-4.3A)
 0.81A 5tzoB-3zseA:
28.6		 5tzoB-3zseA:
55.94
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5TZO_B_7V7B202_1
(ENDO-1,4-BETA-XYLANA
SE A)		 3zse ENDO-1,4-BETA-XYLANA
SE
(Thermobifida
fusca) 		5 / 8 TYR A 157
THR A 159
ARG A 161
GLN A 175
TRP A 177
 None
None
FXP  A1207 (-4.1A)
FXP  A1207 (-4.3A)
None
 0.33A 5tzoB-3zseA:
28.6		 5tzoB-3zseA:
55.94
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5TZO_C_7V7C201_1
(ENDO-1,4-BETA-XYLANA
SE A)		 3zse ENDO-1,4-BETA-XYLANA
SE
(Thermobifida
fusca) 		7 / 12 VAL A  88
TRP A 120
TYR A 129
PRO A 165
TRP A 177
TYR A 210
GLY A 217
 FXP  A1207 (-4.7A)
FXP  A1207 (-4.6A)
None
FXP  A1207 (-3.7A)
None
FXP  A1207 (-4.7A)
None
 0.86A 5tzoC-3zseA:
28.4		 5tzoC-3zseA:
55.94
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5TZO_C_7V7C202_1
(ENDO-1,4-BETA-XYLANA
SE A)		 3zse ENDO-1,4-BETA-XYLANA
SE
(Thermobifida
fusca) 		4 / 8 THR A 140
THR A 159
ARG A 161
GLN A 175
 None
None
FXP  A1207 (-4.1A)
FXP  A1207 (-4.3A)
 0.78A 5tzoC-3zseA:
28.4		 5tzoC-3zseA:
55.94
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5TZO_C_7V7C202_1
(ENDO-1,4-BETA-XYLANA
SE A)		 3zse ENDO-1,4-BETA-XYLANA
SE
(Thermobifida
fusca) 		5 / 8 TYR A 157
THR A 159
ARG A 161
GLN A 175
TRP A 177
 None
None
FXP  A1207 (-4.1A)
FXP  A1207 (-4.3A)
None
 0.43A 5tzoC-3zseA:
28.4		 5tzoC-3zseA:
55.94