SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'FUM'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HRK_B_CHDB2503_0
(FERROCHELATASE)		 5xnz CRED
(Streptomyces
cremeus) 		4 / 4 LEU A 188
PRO A 189
LEU A 229
ARG A 121
 None
None
None
FUM  A 502 (-3.9A)
 1.39A 1hrkB-5xnzA:
undetectable		 1hrkB-5xnzA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1L7F_A_BCZA801_1
(NEURAMINIDASE)		 5xmj FUMARATE REDUCTASE
FLAVOPROTEIN SUBUNIT
(Desulfovibrio
gigas) 		3 / 3 ARG A 301
ARG A 139
ARG A 405
 FUM  A 702 (-2.9A)
None
FUM  A 702 ( 3.0A)
 1.10A 1l7fA-5xmjA:
undetectable		 1l7fA-5xmjA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1L7H_A_BCZA801_1
(NEURAMINIDASE)		 5xmj FUMARATE REDUCTASE
FLAVOPROTEIN SUBUNIT
(Desulfovibrio
gigas) 		3 / 3 ARG A 301
ARG A 139
ARG A 405
 FUM  A 702 (-2.9A)
None
FUM  A 702 ( 3.0A)
 1.07A 1l7hA-5xmjA:
undetectable		 1l7hA-5xmjA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NX9_A_AICA5001_1
(ALPHA-AMINO ACID
ESTER HYDROLASE)		 3sn0 PUTATIVE
L-ALANINE-DL-GLUTAMA
TE EPIMERASE
(Paraburkholderia
xenovorans) 		4 / 8 TYR A 227
GLU A 243
HIS A 123
SER A 122
 None
MG  A 408 (-3.2A)
FUM  A 500 (-4.0A)
None
 1.27A 1nx9A-3sn0A:
undetectable		 1nx9A-3sn0A:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NX9_B_AICB5002_1
(ALPHA-AMINO ACID
ESTER HYDROLASE)		 3sn0 PUTATIVE
L-ALANINE-DL-GLUTAMA
TE EPIMERASE
(Paraburkholderia
xenovorans) 		4 / 8 TYR A 227
GLU A 243
HIS A 123
SER A 122
 None
MG  A 408 (-3.2A)
FUM  A 500 (-4.0A)
None
 1.27A 1nx9B-3sn0A:
undetectable		 1nx9B-3sn0A:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NX9_C_AICC5003_1
(ALPHA-AMINO ACID
ESTER HYDROLASE)		 3sn0 PUTATIVE
L-ALANINE-DL-GLUTAMA
TE EPIMERASE
(Paraburkholderia
xenovorans) 		4 / 8 TYR A 227
GLU A 243
HIS A 123
SER A 122
 None
MG  A 408 (-3.2A)
FUM  A 500 (-4.0A)
None
 1.28A 1nx9C-3sn0A:
undetectable		 1nx9C-3sn0A:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NX9_D_AICD5004_1
(ALPHA-AMINO ACID
ESTER HYDROLASE)		 3sn0 PUTATIVE
L-ALANINE-DL-GLUTAMA
TE EPIMERASE
(Paraburkholderia
xenovorans) 		4 / 8 TYR A 227
GLU A 243
HIS A 123
SER A 122
 None
MG  A 408 (-3.2A)
FUM  A 500 (-4.0A)
None
 1.28A 1nx9D-3sn0A:
undetectable		 1nx9D-3sn0A:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RXC_C_URFC2081_1
(URIDINE
PHOSPHORYLASE)		 1uxi MALATE DEHYDROGENASE
(Chloroflexus
aurantiacus) 		4 / 7 GLY A 214
ARG A  88
ILE A 216
VAL A 217
 FUM  A1311 ( 4.8A)
FUM  A1311 (-4.0A)
None
None
 0.88A 1rxcC-1uxiA:
undetectable		 1rxcC-1uxiA:
24.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T87_B_CAMB2422_0
(CYTOCHROME P450-CAM)		 2eeo ASPARTATE
1-DECARBOXYLASE
(Thermus
thermophilus) 		4 / 7 THR B  57
LEU B  55
VAL B  79
ILE B  69
 FUM  B 501 ( 3.6A)
None
None
None
 0.94A 1t87B-2eeoB:
undetectable		 1t87B-2eeoB:
12.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WOP_A_FFOA2887_1
(AMINOMETHYLTRANSFERA
SE)		 1uxi MALATE DEHYDROGENASE
(Chloroflexus
aurantiacus) 		3 / 3 ASP A  90
GLU A 178
ARG A 151
 None
None
FUM  A1311 (-2.8A)
 0.68A 1wopA-1uxiA:
0.0		 1wopA-1uxiA:
23.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AOU_A_CQAA403_0
(HISTAMINE
N-METHYLTRANSFERASE)		 5xmj FUMARATE REDUCTASE
FLAVOPROTEIN SUBUNIT
(Desulfovibrio
gigas) 		4 / 8 ASP A 302
GLY A 142
PHE A 141
THR A 269
 None
None
FUM  A 702 (-4.3A)
FUM  A 702 (-3.4A)
 0.90A 2aouA-5xmjA:
undetectable		 2aouA-5xmjA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EJ3_C_GBNC1414_1
(BRANCHED-CHAIN AMINO
ACID
AMINOTRANSFERASE)		 1d4e FLAVOCYTOCHROME C
FUMARATE REDUCTASE
(Shewanella
oneidensis) 		5 / 8 TYR A 434
GLY A 169
GLY A 251
ALA A 430
ALA A 250
 HEM  A 601 (-4.3A)
FUM  A 700 ( 3.0A)
None
HEM  A 601 ( 3.8A)
None
 1.31A 2ej3C-1d4eA:
undetectable		 2ej3C-1d4eA:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HRC_B_CHDB1604_0
(FERROCHELATASE)		 5xnz CRED
(Streptomyces
cremeus) 		4 / 4 LEU A 188
PRO A 189
LEU A 229
ARG A 121
 None
None
None
FUM  A 502 (-3.9A)
 1.36A 2hrcB-5xnzA:
undetectable		 2hrcB-5xnzA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2L8M_A_CAMA415_0
(CAMPHOR
5-MONOOXYGENASE)		 2eeo ASPARTATE
1-DECARBOXYLASE
ASPARTATE
1-DECARBOXYLASE
(Thermus
thermophilus;
Thermus
thermophilus) 		5 / 9 THR B  57
LEU B  55
VAL B  79
ILE B  69
VAL A  15
 FUM  B 501 ( 3.6A)
None
None
None
None
 1.46A 2l8mA-2eeoB:
undetectable		 2l8mA-2eeoB:
12.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VXA_G_RBFG200_1
(DODECIN)		 3vrb FLAVOPROTEIN SUBUNIT
OF COMPLEX II
(Ascaris
suum) 		4 / 8 ARG A 320
HIS A 428
THR A 169
GLN A 156
 FUM  A 701 (-3.2A)
None
None
None
 1.31A 2vxaF-3vrbA:
undetectable
2vxaG-3vrbA:
undetectable
2vxaI-3vrbA:
undetectable		 2vxaF-3vrbA:
9.31
2vxaG-3vrbA:
9.31
2vxaI-3vrbA:
9.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ABK_B_CHDB1085_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 2
CYTOCHROME C OXIDASE
SUBUNIT 6A2)		 3vrb FLAVOPROTEIN SUBUNIT
OF COMPLEX II
IRON-SULFUR SUBUNIT
OF SUCCINATE
DEHYDROGENASE
(Ascaris
suum;
Ascaris
suum) 		5 / 11 GLN A  84
GLU B  91
THR A 366
ARG A 320
GLY A 279
 None
FAD  A 702 ( 4.4A)
None
FUM  A 701 (-3.2A)
None
 1.39A 3abkA-3vrbA:
1.6
3abkB-3vrbA:
undetectable
3abkT-3vrbA:
undetectable		 3abkA-3vrbA:
22.27
3abkB-3vrbA:
15.62
3abkT-3vrbA:
8.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ABL_B_CHDB1086_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 2
CYTOCHROME C OXIDASE
SUBUNIT 6A2)		 3vrb FLAVOPROTEIN SUBUNIT
OF COMPLEX II
IRON-SULFUR SUBUNIT
OF SUCCINATE
DEHYDROGENASE
(Ascaris
suum;
Ascaris
suum) 		5 / 11 GLN A  84
GLU B  91
THR A 366
ARG A 320
GLY A 279
 None
FAD  A 702 ( 4.4A)
None
FUM  A 701 (-3.2A)
None
 1.44A 3ablA-3vrbA:
1.2
3ablB-3vrbA:
undetectable
3ablT-3vrbA:
undetectable		 3ablA-3vrbA:
22.27
3ablB-3vrbA:
15.62
3ablT-3vrbA:
8.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG3_B_CHDB1085_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 2
CYTOCHROME C OXIDASE
SUBUNIT 6A2)		 3vrb FLAVOPROTEIN SUBUNIT
OF COMPLEX II
IRON-SULFUR SUBUNIT
OF SUCCINATE
DEHYDROGENASE
(Ascaris
suum;
Ascaris
suum) 		5 / 11 GLN A  84
GLU B  91
THR A 366
ARG A 320
GLY A 279
 None
FAD  A 702 ( 4.4A)
None
FUM  A 701 (-3.2A)
None
 1.39A 3ag3A-3vrbA:
1.2
3ag3B-3vrbA:
undetectable
3ag3T-3vrbA:
undetectable		 3ag3A-3vrbA:
22.27
3ag3B-3vrbA:
15.62
3ag3T-3vrbA:
8.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AOD_C_RFPC2002_1
(ACRIFLAVINE
RESISTANCE PROTEIN B)		 5xmj FUMARATE REDUCTASE
FLAVOPROTEIN SUBUNIT
(Desulfovibrio
gigas) 		5 / 12 GLN A 297
PHE A 141
ALA A 140
GLY A 120
LEU A 333
 None
FUM  A 702 (-4.3A)
None
None
None
 1.26A 3aodC-5xmjA:
undetectable		 3aodC-5xmjA:
5.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EIG_A_MTXA200_2
(DIHYDROFOLATE
REDUCTASE)		 5xnz CRED
(Streptomyces
cremeus) 		4 / 5 ASP A 131
ARG A 185
ILE A 126
VAL A 249
 None
FUM  A 502 (-3.2A)
None
None
 1.23A 3eigA-5xnzA:
undetectable		 3eigA-5xnzA:
17.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EL9_A_DR7A100_1
(PROTEASE)		 1d4e FLAVOCYTOCHROME C
FUMARATE REDUCTASE
(Shewanella
oneidensis) 		4 / 8 ALA A 168
GLY A 546
PRO A 365
THR A 366
 FUM  A 700 (-3.8A)
FUM  A 700 (-3.6A)
None
None
 0.75A 3el9A-1d4eA:
undetectable		 3el9A-1d4eA:
10.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EL9_A_DR7A100_1
(PROTEASE)		 1m64 FLAVOCYTOCHROME C3
(Shewanella
frigidimarina) 		4 / 8 ALA A 169
GLY A 546
PRO A 366
THR A 367
 FUM  A3001 (-4.0A)
FUM  A3001 (-3.3A)
None
None
 0.71A 3el9A-1m64A:
undetectable		 3el9A-1m64A:
11.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GGU_B_017B201_2
(PROTEASE)		 1m64 FLAVOCYTOCHROME C3
(Shewanella
frigidimarina) 		5 / 9 GLY A 234
ALA A 244
GLY A 237
ILE A 399
THR A 377
 None
None
None
None
FUM  A3001 (-3.7A)
 0.99A 3gguB-1m64A:
undetectable		 3gguB-1m64A:
10.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HCN_A_CHDA3_0
(FERROCHELATASE,
MITOCHONDRIAL)		 1d4e FLAVOCYTOCHROME C
FUMARATE REDUCTASE
(Shewanella
oneidensis) 		4 / 7 LEU A 418
ARG A 401
SER A 427
GLY A 169
 None
FUM  A 700 (-3.2A)
None
FUM  A 700 ( 3.0A)
 0.98A 3hcnA-1d4eA:
undetectable		 3hcnA-1d4eA:
18.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JUS_B_ECLB600_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 1qlb FUMARATE REDUCTASE
FLAVOPROTEIN SUBUNIT
FUMARATE REDUCTASE
IRON-SULFUR PROTEIN
(Wolinella
succinogenes) 		4 / 8 LEU A 268
THR A 269
ALA A  47
ILE B  61
 None
FUM  A1657 (-4.5A)
FAD  A1656 (-3.6A)
None
 0.81A 3jusB-1qlbA:
undetectable		 3jusB-1qlbA:
22.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MIH_A_CUA358_0
(PEPTIDYL-GLYCINE
ALPHA-AMIDATING
MONOOXYGENASE)		 1m64 FLAVOCYTOCHROME C3
(Shewanella
frigidimarina) 		3 / 3 HIS A 504
HIS A 365
MET A 375
 FUM  A3001 ( 4.1A)
FUM  A3001 (-4.2A)
FAD  A3000 ( 3.5A)
 1.03A 3mihA-1m64A:
0.0		 3mihA-1m64A:
20.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NDV_A_AICA375_1
(BETA-PEPTIDYL
AMINOPEPTIDASE)		 1d4e FLAVOCYTOCHROME C
FUMARATE REDUCTASE
(Shewanella
oneidensis) 		5 / 11 THR A 195
LEU A 545
ARG A 401
ASN A 543
LEU A 211
 None
None
FUM  A 700 (-3.2A)
None
None
 1.32A 3ndvA-1d4eA:
0.0
3ndvB-1d4eA:
0.0		 3ndvA-1d4eA:
21.61
3ndvB-1d4eA:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NDV_A_AICA375_1
(BETA-PEPTIDYL
AMINOPEPTIDASE)		 3vrb FLAVOPROTEIN SUBUNIT
OF COMPLEX II
(Ascaris
suum) 		5 / 11 THR A 106
LEU A 433
ARG A 320
ASN A 431
LEU A 122
 None
None
FUM  A 701 (-3.2A)
None
None
 1.27A 3ndvA-3vrbA:
undetectable
3ndvB-3vrbA:
undetectable		 3ndvA-3vrbA:
22.33
3ndvB-3vrbA:
22.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NDV_B_AICB376_1
(BETA-PEPTIDYL
AMINOPEPTIDASE)		 1d4e FLAVOCYTOCHROME C
FUMARATE REDUCTASE
(Shewanella
oneidensis) 		5 / 11 LEU A 211
THR A 195
LEU A 545
ARG A 401
ASN A 543
 None
None
None
FUM  A 700 (-3.2A)
None
 1.37A 3ndvA-1d4eA:
0.0
3ndvB-1d4eA:
0.0		 3ndvA-1d4eA:
21.61
3ndvB-1d4eA:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NDV_B_AICB376_1
(BETA-PEPTIDYL
AMINOPEPTIDASE)		 3vrb FLAVOPROTEIN SUBUNIT
OF COMPLEX II
(Ascaris
suum) 		5 / 11 LEU A 122
THR A 106
LEU A 433
ARG A 320
ASN A 431
 None
None
None
FUM  A 701 (-3.2A)
None
 1.31A 3ndvA-3vrbA:
undetectable
3ndvB-3vrbA:
undetectable		 3ndvA-3vrbA:
22.33
3ndvB-3vrbA:
22.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NDV_C_AICC375_1
(BETA-PEPTIDYL
AMINOPEPTIDASE)		 3vrb FLAVOPROTEIN SUBUNIT
OF COMPLEX II
(Ascaris
suum) 		5 / 11 THR A 106
LEU A 433
ARG A 320
ASN A 431
LEU A 122
 None
None
FUM  A 701 (-3.2A)
None
None
 1.28A 3ndvC-3vrbA:
undetectable
3ndvD-3vrbA:
undetectable		 3ndvC-3vrbA:
22.33
3ndvD-3vrbA:
22.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NDV_D_AICD374_1
(BETA-PEPTIDYL
AMINOPEPTIDASE)		 3vrb FLAVOPROTEIN SUBUNIT
OF COMPLEX II
(Ascaris
suum) 		5 / 11 LEU A 122
THR A 106
LEU A 433
ARG A 320
ASN A 431
 None
None
None
FUM  A 701 (-3.2A)
None
 1.28A 3ndvC-3vrbA:
undetectable
3ndvD-3vrbA:
undetectable		 3ndvC-3vrbA:
22.33
3ndvD-3vrbA:
22.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DT8_A_ADNA401_1
(APH(2'')-ID)		 3vrb FLAVOPROTEIN SUBUNIT
OF COMPLEX II
(Ascaris
suum) 		5 / 11 SER A 291
GLY A 290
ILE A 363
ILE A 280
HIS A 387
 None
None
None
None
FUM  A 701 ( 3.6A)
 1.01A 4dt8A-3vrbA:
undetectable		 4dt8A-3vrbA:
18.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E47_A_SAMA401_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD7)		 1d4e FLAVOCYTOCHROME C
FUMARATE REDUCTASE
(Shewanella
oneidensis) 		5 / 11 ILE A 424
GLY A 381
GLU A 377
ASN A 396
TYR A 467
 None
None
FUM  A 700 (-4.6A)
None
None
 1.20A 4e47A-1d4eA:
undetectable		 4e47A-1d4eA:
18.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E47_B_SAMB800_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD7)		 1d4e FLAVOCYTOCHROME C
FUMARATE REDUCTASE
(Shewanella
oneidensis) 		5 / 11 ILE A 424
GLY A 381
GLU A 377
ASN A 396
TYR A 467
 None
None
FUM  A 700 (-4.6A)
None
None
 1.22A 4e47B-1d4eA:
undetectable		 4e47B-1d4eA:
18.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGL_C_CLQC303_0
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 5bwd BENZYLSUCCINATE
SYNTHASE ALPHA CHAIN
(Thauera
aromatica) 		4 / 5 GLY A 511
GLY A 512
ASN A 615
GLU A 510
 None
FUM  A 901 (-3.5A)
FUM  A 901 (-3.6A)
None
 1.25A 4fglC-5bwdA:
undetectable		 4fglC-5bwdA:
13.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G0V_D_MIXD101_1
(DNA TOPOISOMERASE
2-BETA)		 1uxi MALATE DEHYDROGENASE
(Chloroflexus
aurantiacus) 		4 / 6 ARG A  88
GLY A 174
GLN A 143
MET A 236
 FUM  A1311 (-4.0A)
None
NAD  A1310 (-3.7A)
None
 1.14A 4g0vB-1uxiA:
undetectable		 4g0vB-1uxiA:
17.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JVL_A_ESTA702_1
(ESTROGEN
SULFOTRANSFERASE)		 3sn0 PUTATIVE
L-ALANINE-DL-GLUTAMA
TE EPIMERASE
(Paraburkholderia
xenovorans) 		4 / 9 TYR A 319
LYS A 161
HIS A 123
PHE A  39
 None
FUM  A 500 (-3.3A)
FUM  A 500 (-4.0A)
None
 1.33A 4jvlA-3sn0A:
undetectable		 4jvlA-3sn0A:
19.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MK4_B_CHDB503_0
(FERROCHELATASE,
MITOCHONDRIAL)		 5xmj FUMARATE REDUCTASE
FLAVOPROTEIN SUBUNIT
(Desulfovibrio
gigas) 		5 / 11 LEU A 279
LEU A 328
CYH A 272
HIS A 257
VAL A 345
 None
None
None
FUM  A 702 (-3.9A)
None
 1.21A 4mk4B-5xmjA:
undetectable		 4mk4B-5xmjA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UIN_H_QI9H1226_0
(FAB 314.3)		 5xmj FUMARATE REDUCTASE
FLAVOPROTEIN SUBUNIT
(Desulfovibrio
gigas) 		5 / 12 HIS A 257
SER A 305
GLU A 270
GLY A 142
GLY A 277
 FUM  A 702 (-3.9A)
None
FUM  A 702 (-4.7A)
None
None
 1.49A 4uinH-5xmjA:
undetectable
4uinL-5xmjA:
undetectable		 4uinH-5xmjA:
undetectable
4uinL-5xmjA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UIN_H_QI9H1226_0
(FAB 314.3)		 5xmj FUMARATE REDUCTASE
FLAVOPROTEIN SUBUNIT
(Desulfovibrio
gigas) 		5 / 12 HIS A 257
THR A 259
GLU A 270
GLY A 142
GLY A  50
 FUM  A 702 (-3.9A)
None
FUM  A 702 (-4.7A)
None
FAD  A 701 (-4.8A)
 1.47A 4uinH-5xmjA:
undetectable
4uinL-5xmjA:
undetectable		 4uinH-5xmjA:
undetectable
4uinL-5xmjA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WQD_A_GAIA1005_0
(THIOSULFATE
DEHYDROGENASE)		 1uxi MALATE DEHYDROGENASE
(Chloroflexus
aurantiacus) 		4 / 4 ARG A  88
ARG A  82
GLY A 212
ARG A 151
 FUM  A1311 (-4.0A)
FUM  A1311 (-3.6A)
None
FUM  A1311 (-2.8A)
 0.99A 4wqdA-1uxiA:
0.0		 4wqdA-1uxiA:
24.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZVM_A_DM2A303_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 5bwd BENZYLSUCCINATE
SYNTHASE ALPHA CHAIN
(Thauera
aromatica) 		5 / 12 GLY A 511
GLY A 512
ASN A 615
GLU A 510
ILE A 570
 None
FUM  A 901 (-3.5A)
FUM  A 901 (-3.6A)
None
None
 1.25A 4zvmA-5bwdA:
undetectable
4zvmB-5bwdA:
undetectable		 4zvmA-5bwdA:
13.21
4zvmB-5bwdA:
13.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B1B_G_CHDG103_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 2
CYTOCHROME C OXIDASE
SUBUNIT 6A2,
MITOCHONDRIAL)		 3vrb FLAVOPROTEIN SUBUNIT
OF COMPLEX II
IRON-SULFUR SUBUNIT
OF SUCCINATE
DEHYDROGENASE
(Ascaris
suum;
Ascaris
suum) 		5 / 11 ARG A 320
GLY A 279
GLN A  84
GLU B  91
THR A 366
 FUM  A 701 (-3.2A)
None
None
FAD  A 702 ( 4.4A)
None
 1.39A 5b1bG-3vrbA:
undetectable
5b1bN-3vrbA:
1.7
5b1bO-3vrbA:
undetectable		 5b1bG-3vrbA:
8.69
5b1bN-3vrbA:
22.27
5b1bO-3vrbA:
15.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E26_B_PAUB601_0
(PANTOTHENATE KINASE
2, MITOCHONDRIAL)		 1qlb FUMARATE REDUCTASE
FLAVOPROTEIN SUBUNIT
(Wolinella
succinogenes) 		5 / 7 ALA A  47
GLU A 393
SER A 409
ARG A 404
GLY A 407
 FAD  A1656 (-3.6A)
FAD  A1656 ( 3.6A)
FAD  A1656 (-2.7A)
FUM  A1657 ( 2.7A)
FAD  A1656 ( 3.0A)
 1.27A 5e26A-1qlbA:
undetectable
5e26B-1qlbA:
undetectable		 5e26A-1qlbA:
19.64
5e26B-1qlbA:
19.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E26_D_PAUD601_0
(PANTOTHENATE KINASE
2, MITOCHONDRIAL)		 5xmj FUMARATE REDUCTASE
FLAVOPROTEIN SUBUNIT
(Desulfovibrio
gigas) 		4 / 8 GLU A 394
SER A 410
ARG A 405
GLY A 408
 FAD  A 701 (-4.2A)
FAD  A 701 (-3.5A)
FUM  A 702 ( 3.0A)
FAD  A 701 ( 3.4A)
 0.76A 5e26C-5xmjA:
undetectable
5e26D-5xmjA:
undetectable		 5e26C-5xmjA:
undetectable
5e26D-5xmjA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEI_A_SHHA2004_1
(HDAC6 PROTEIN)		 1d4e FLAVOCYTOCHROME C
FUMARATE REDUCTASE
(Shewanella
oneidensis) 		5 / 12 HIS A 504
GLY A 546
HIS A 540
ASP A 552
LEU A 211
 FAD  A 600 (-3.8A)
FUM  A 700 (-3.6A)
None
None
None
 1.21A 5eeiA-1d4eA:
undetectable		 5eeiA-1d4eA:
19.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEI_B_SHHB801_1
(HDAC6 PROTEIN)		 1d4e FLAVOCYTOCHROME C
FUMARATE REDUCTASE
(Shewanella
oneidensis) 		5 / 12 HIS A 504
GLY A 546
HIS A 540
ASP A 552
LEU A 211
 FAD  A 600 (-3.8A)
FUM  A 700 (-3.6A)
None
None
None
 1.23A 5eeiB-1d4eA:
undetectable		 5eeiB-1d4eA:
19.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KKZ_A_ASCA1004_0
(CYTOCHROME B
UBIQUINOL-CYTOCHROME
C REDUCTASE
IRON-SULFUR SUBUNIT)		 1qlb FUMARATE REDUCTASE
FLAVOPROTEIN SUBUNIT
(Wolinella
succinogenes) 		4 / 6 VAL A 410
ARG A 404
GLN A  52
HIS A 400
 FAD  A1656 (-3.7A)
FUM  A1657 ( 2.7A)
None
None
 1.44A 5kkzA-1qlbA:
0.0
5kkzG-1qlbA:
0.0		 5kkzA-1qlbA:
21.67
5kkzG-1qlbA:
14.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KPR_A_PAUA404_0
(PANTOTHENATE KINASE
3)		 1qlb FUMARATE REDUCTASE
FLAVOPROTEIN SUBUNIT
(Wolinella
succinogenes) 		4 / 5 GLU A 393
SER A 409
ARG A 404
GLY A 407
 FAD  A1656 ( 3.6A)
FAD  A1656 (-2.7A)
FUM  A1657 ( 2.7A)
FAD  A1656 ( 3.0A)
 0.92A 5kprA-1qlbA:
undetectable		 5kprA-1qlbA:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KPR_A_PAUA404_0
(PANTOTHENATE KINASE
3)		 5xmj FUMARATE REDUCTASE
FLAVOPROTEIN SUBUNIT
(Desulfovibrio
gigas) 		4 / 5 GLU A 394
SER A 410
ARG A 405
GLY A 408
 FAD  A 701 (-4.2A)
FAD  A 701 (-3.5A)
FUM  A 702 ( 3.0A)
FAD  A 701 ( 3.4A)
 0.85A 5kprA-5xmjA:
undetectable		 5kprA-5xmjA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UC1_A_486A801_2
(GLUCOCORTICOID
RECEPTOR)		 5bwd BENZYLSUCCINATE
SYNTHASE ALPHA CHAIN
(Thauera
aromatica) 		3 / 3 TRP A 613
MET A 494
ASN A 490
 FUM  A 901 (-4.5A)
None
None
 1.48A 5uc1B-5bwdA:
undetectable		 5uc1B-5bwdA:
7.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UC1_B_486B801_1
(GLUCOCORTICOID
RECEPTOR)		 5bwd BENZYLSUCCINATE
SYNTHASE ALPHA CHAIN
(Thauera
aromatica) 		3 / 3 TRP A 613
MET A 494
ASN A 490
 FUM  A 901 (-4.5A)
None
None
 1.45A 5uc1A-5bwdA:
undetectable		 5uc1A-5bwdA:
7.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V96_A_ADNA502_2
(S-ADENOSYL-L-HOMOCYS
TEINE HYDROLASE)		 5xmj FUMARATE REDUCTASE
FLAVOPROTEIN SUBUNIT
(Desulfovibrio
gigas) 		4 / 4 GLU A 270
THR A 269
THR A 152
LEU A 411
 FUM  A 702 (-4.7A)
FUM  A 702 (-3.4A)
None
FAD  A 701 (-3.7A)
 1.40A 5v96A-5xmjA:
2.1		 5v96A-5xmjA:
9.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V96_B_ADNB502_2
(S-ADENOSYL-L-HOMOCYS
TEINE HYDROLASE)		 5xmj FUMARATE REDUCTASE
FLAVOPROTEIN SUBUNIT
(Desulfovibrio
gigas) 		4 / 4 GLU A 270
THR A 269
THR A 152
LEU A 411
 FUM  A 702 (-4.7A)
FUM  A 702 (-3.4A)
None
FAD  A 701 (-3.7A)
 1.39A 5v96B-5xmjA:
undetectable		 5v96B-5xmjA:
9.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V96_C_ADNC502_2
(S-ADENOSYL-L-HOMOCYS
TEINE HYDROLASE)		 5xmj FUMARATE REDUCTASE
FLAVOPROTEIN SUBUNIT
(Desulfovibrio
gigas) 		4 / 4 GLU A 270
THR A 269
THR A 152
LEU A 411
 FUM  A 702 (-4.7A)
FUM  A 702 (-3.4A)
None
FAD  A 701 (-3.7A)
 1.41A 5v96C-5xmjA:
2.0		 5v96C-5xmjA:
9.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V96_D_ADND502_2
(S-ADENOSYL-L-HOMOCYS
TEINE HYDROLASE)		 5xmj FUMARATE REDUCTASE
FLAVOPROTEIN SUBUNIT
(Desulfovibrio
gigas) 		4 / 4 GLU A 270
THR A 269
THR A 152
LEU A 411
 FUM  A 702 (-4.7A)
FUM  A 702 (-3.4A)
None
FAD  A 701 (-3.7A)
 1.41A 5v96D-5xmjA:
undetectable		 5v96D-5xmjA:
9.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X1F_G_CHDG104_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 2
CYTOCHROME C OXIDASE
SUBUNIT 6A2,
MITOCHONDRIAL)		 3vrb FLAVOPROTEIN SUBUNIT
OF COMPLEX II
IRON-SULFUR SUBUNIT
OF SUCCINATE
DEHYDROGENASE
(Ascaris
suum;
Ascaris
suum) 		5 / 11 ARG A 320
GLY A 279
GLN A  84
GLU B  91
THR A 366
 FUM  A 701 (-3.2A)
None
None
FAD  A 702 ( 4.4A)
None
 1.48A 5x1fG-3vrbA:
undetectable
5x1fN-3vrbA:
0.8
5x1fO-3vrbA:
undetectable		 5x1fG-3vrbA:
8.69
5x1fN-3vrbA:
22.27
5x1fO-3vrbA:
15.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X80_B_SALB203_1
(UNCHARACTERIZED
HTH-TYPE
TRANSCRIPTIONAL
REGULATOR RV2887)		 3vrb FLAVOPROTEIN SUBUNIT
OF COMPLEX II
(Ascaris
suum) 		4 / 6 PRO A 277
LEU A 317
ARG A 320
VAL A 323
 None
None
FUM  A 701 (-3.2A)
None
 0.98A 5x80A-3vrbA:
undetectable
5x80B-3vrbA:
undetectable		 5x80A-3vrbA:
13.58
5x80B-3vrbA:
13.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z84_B_CHDB301_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 2
CYTOCHROME C OXIDASE
SUBUNIT 6A2,
MITOCHONDRIAL)		 3vrb FLAVOPROTEIN SUBUNIT
OF COMPLEX II
IRON-SULFUR SUBUNIT
OF SUCCINATE
DEHYDROGENASE
(Ascaris
suum;
Ascaris
suum) 		5 / 11 GLN A  84
GLU B  91
THR A 366
ARG A 320
GLY A 279
 None
FAD  A 702 ( 4.4A)
None
FUM  A 701 (-3.2A)
None
 1.44A 5z84A-3vrbA:
0.7
5z84B-3vrbA:
undetectable
5z84T-3vrbA:
undetectable		 5z84A-3vrbA:
22.27
5z84B-3vrbA:
15.62
5z84T-3vrbA:
8.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z86_B_CHDB302_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 2
CYTOCHROME C OXIDASE
SUBUNIT 6A2,
MITOCHONDRIAL)		 3vrb FLAVOPROTEIN SUBUNIT
OF COMPLEX II
IRON-SULFUR SUBUNIT
OF SUCCINATE
DEHYDROGENASE
(Ascaris
suum;
Ascaris
suum) 		5 / 11 GLN A  84
GLU B  91
THR A 366
ARG A 320
GLY A 279
 None
FAD  A 702 ( 4.4A)
None
FUM  A 701 (-3.2A)
None
 1.46A 5z86A-3vrbA:
undetectable
5z86B-3vrbA:
undetectable
5z86T-3vrbA:
undetectable		 5z86A-3vrbA:
22.27
5z86B-3vrbA:
15.62
5z86T-3vrbA:
8.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZCQ_B_CHDB301_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 2
CYTOCHROME C OXIDASE
SUBUNIT 6A2,
MITOCHONDRIAL)		 3vrb FLAVOPROTEIN SUBUNIT
OF COMPLEX II
IRON-SULFUR SUBUNIT
OF SUCCINATE
DEHYDROGENASE
(Ascaris
suum;
Ascaris
suum) 		5 / 11 GLN A  84
GLU B  91
THR A 366
ARG A 320
GLY A 279
 None
FAD  A 702 ( 4.4A)
None
FUM  A 701 (-3.2A)
None
 1.43A 5zcqA-3vrbA:
0.0
5zcqB-3vrbA:
undetectable
5zcqT-3vrbA:
undetectable		 5zcqA-3vrbA:
22.27
5zcqB-3vrbA:
15.62
5zcqT-3vrbA:
8.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B58_A_ACTA609_0
(FUMARATE REDUCTASE
FLAVOPROTEIN SUBUNIT)		 1d4e FLAVOCYTOCHROME C
FUMARATE REDUCTASE
(Shewanella
oneidensis) 		3 / 3 HIS A 364
HIS A 503
ARG A 544
 FUM  A 700 (-4.7A)
FUM  A 700 ( 4.1A)
FUM  A 700 ( 3.0A)
 0.47A 6b58A-1d4eA:
32.3		 6b58A-1d4eA:
22.93
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6B58_A_ACTA609_0
(FUMARATE REDUCTASE
FLAVOPROTEIN SUBUNIT)		 1qlb FUMARATE REDUCTASE
FLAVOPROTEIN SUBUNIT
(Wolinella
succinogenes) 		3 / 3 HIS A 257
HIS A 369
ARG A 404
 FUM  A1657 (-4.0A)
FUM  A1657 ( 3.7A)
FUM  A1657 ( 2.7A)
 0.37A 6b58A-1qlbA:
44.1		 6b58A-1qlbA:
35.10
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6B58_A_ACTA609_0
(FUMARATE REDUCTASE
FLAVOPROTEIN SUBUNIT)		 3vrb FLAVOPROTEIN SUBUNIT
OF COMPLEX II
(Ascaris
suum) 		3 / 3 HIS A 276
HIS A 387
ARG A 432
 FUM  A 701 (-4.3A)
FUM  A 701 ( 3.6A)
FUM  A 701 ( 2.3A)
 0.83A 6b58A-3vrbA:
50.4		 6b58A-3vrbA:
38.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B58_A_ACTA609_0
(FUMARATE REDUCTASE
FLAVOPROTEIN SUBUNIT)		 5xmj FUMARATE REDUCTASE
FLAVOPROTEIN SUBUNIT
(Desulfovibrio
gigas) 		3 / 3 HIS A 257
HIS A 369
ARG A 405
 FUM  A 702 (-3.9A)
FUM  A 702 ( 3.4A)
FUM  A 702 ( 3.0A)
 0.86A 6b58A-5xmjA:
53.8		 6b58A-5xmjA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DWD_D_GLYD713_0
(DEOXYNUCLEOSIDE
TRIPHOSPHATE
TRIPHOSPHOHYDROLASE
SAMHD1)		 1qlb FUMARATE REDUCTASE
FLAVOPROTEIN SUBUNIT
(Wolinella
succinogenes) 		3 / 3 ARG A 301
HIS A 369
ARG A 404
 FUM  A1657 (-2.6A)
FUM  A1657 ( 3.7A)
FUM  A1657 ( 2.7A)
 0.89A 6dwdD-1qlbA:
0.0		 6dwdD-1qlbA:
20.61