SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'FUL'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AOH_C_FRDC305_1
(POL POLYPROTEIN
PEPTIDE INHIBITOR)		 6egt GLYCOPROTEIN
(Rift
Valley
fever
phlebovirus) 		4 / 5 LEU A1034
ASP A1081
GLY A1078
ALA A1032
 NAG  A1302 ( 4.4A)
NAG  A1302 (-3.5A)
FUL  A1304 ( 4.2A)
None
 0.97A 2aohA-6egtA:
undetectable		 2aohA-6egtA:
12.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E7C_A_ACTA504_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)		 5ege ECTONUCLEOTIDE
PYROPHOSPHATASE/PHOS
PHODIESTERASE FAMILY
MEMBER 6
(Mus
musculus) 		3 / 3 ARG A 346
TRP A 339
GLY A 348
 None
FUL  A 505 ( 4.4A)
NAG  A 503 ( 3.8A)
 1.02A 4e7cA-5egeA:
undetectable		 4e7cA-5egeA:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KLA_A_CHDA501_0
(FERROCHELATASE,
MITOCHONDRIAL)		 2eae ALPHA-FUCOSIDASE
(Bifidobacterium
bifidum) 		4 / 7 ARG A 677
SER A 580
VAL A 422
TRP A 509
 FUL  A 900 (-3.6A)
None
None
None
 1.50A 4klaA-2eaeA:
0.0		 4klaA-2eaeA:
16.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KM0_B_CP6B201_1
(DIHYDROFOLATE
REDUCTASE)		 4a34 RBSD/FUCU TRANSPORT
PROTEIN FAMILY
PROTEIN
(Streptococcus
pneumoniae) 		5 / 12 TRP A  86
ALA A 131
ILE A  50
ASP A  30
ILE A 134
 None
None
None
FUL  A1142 (-2.8A)
None
 1.10A 4km0B-4a34A:
undetectable		 4km0B-4a34A:
18.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NZ0_A_ZLDA301_0
(HTH-TYPE
TRANSCRIPTIONAL
REGULATOR ETHR)		 2eae ALPHA-FUCOSIDASE
(Bifidobacterium
bifidum) 		5 / 12 TRP A 722
GLY A 725
ILE A 724
VAL A 422
LEU A 716
 FUL  A 900 ( 3.9A)
None
None
None
None
 1.18A 5nz0A-2eaeA:
1.8		 5nz0A-2eaeA:
12.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ODQ_D_ACTD202_0
(METHYL-VIOLOGEN
REDUCING
HYDROGENASE, SUBUNIT
D)		 1odu PUTATIVE
ALPHA-L-FUCOSIDASE
(Thermotoga
maritima) 		3 / 3 HIS A 129
GLU A  66
TRP A  67
 FUL  A1448 (-4.0A)
FUL  A1448 (-3.3A)
FUL  A1448 (-4.1A)
 1.13A 5odqD-1oduA:
undetectable		 5odqD-1oduA:
15.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNF_A_QPSA602_1
(-)		 1odu PUTATIVE
ALPHA-L-FUCOSIDASE
(Thermotoga
maritima) 		5 / 12 ASN A  62
PHE A  59
ASN A 293
GLU A  66
GLY A 291
 None
None
None
FUL  A1448 (-3.3A)
None
 1.15A 6gnfA-1oduA:
2.0		 6gnfA-1oduA:
21.66