SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'FUG'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HA4_A_ACHA546_0
(ACETYLCHOLINESTERASE)		 3fmq METHIONINE
AMINOPEPTIDASE 2
(Encephalitozoon
cuniculi) 		4 / 8 TYR A 324
GLU A 243
HIS A 210
GLY A 209
 FUG  A 481 (-3.9A)
FE  A 451 ( 2.7A)
FE  A 451 (-3.4A)
None
 0.80A 2ha4A-3fmqA:
undetectable		 2ha4A-3fmqA:
19.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HA4_B_ACHB603_0
(ACETYLCHOLINESTERASE)		 3fmq METHIONINE
AMINOPEPTIDASE 2
(Encephalitozoon
cuniculi) 		4 / 7 TYR A 324
GLU A 243
HIS A 210
GLY A 209
 FUG  A 481 (-3.9A)
FE  A 451 ( 2.7A)
FE  A 451 (-3.4A)
None
 0.78A 2ha4B-3fmqA:
undetectable		 2ha4B-3fmqA:
19.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVQ_K_BO2K301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 3fmq METHIONINE
AMINOPEPTIDASE 2
(Encephalitozoon
cuniculi) 		5 / 9 THR A 247
ALA A 107
ALA A 108
ILE A 330
GLY A 251
 None
None
FUG  A 481 ( 4.4A)
None
None
 1.01A 4qvqK-3fmqA:
undetectable
4qvqL-3fmqA:
undetectable		 4qvqK-3fmqA:
23.12
4qvqL-3fmqA:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVQ_Y_BO2Y301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 3fmq METHIONINE
AMINOPEPTIDASE 2
(Encephalitozoon
cuniculi) 		5 / 9 THR A 247
ALA A 107
ALA A 108
ILE A 330
GLY A 251
 None
None
FUG  A 481 ( 4.4A)
None
None
 1.00A 4qvqY-3fmqA:
undetectable
4qvqZ-3fmqA:
undetectable		 4qvqY-3fmqA:
23.12
4qvqZ-3fmqA:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DV4_A_NMYA601_1
(CCR4-NOT
TRANSCRIPTION
COMPLEX SUBUNIT
6-LIKE)		 3fmq METHIONINE
AMINOPEPTIDASE 2
(Encephalitozoon
cuniculi) 		5 / 12 LEU A 327
PRO A  98
ASP A 141
ILE A 217
HIS A 210
 None
None
FE  A 452 ( 2.2A)
FUG  A 481 (-4.5A)
FE  A 451 (-3.4A)
 1.45A 5dv4A-3fmqA:
undetectable		 5dv4A-3fmqA:
23.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M8R_B_MMSB514_1
(5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE)		 3fmq METHIONINE
AMINOPEPTIDASE 2
(Encephalitozoon
cuniculi) 		4 / 8 HIS A 261
SER A 308
HIS A 297
LEU A 298
 FUG  A 481 ( 4.9A)
None
None
None
 0.93A 5m8rB-3fmqA:
undetectable		 5m8rB-3fmqA:
20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M8R_D_MMSD509_1
(5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE)		 3fmq METHIONINE
AMINOPEPTIDASE 2
(Encephalitozoon
cuniculi) 		4 / 8 HIS A 261
SER A 308
HIS A 297
LEU A 298
 FUG  A 481 ( 4.9A)
None
None
None
 0.95A 5m8rD-3fmqA:
undetectable		 5m8rD-3fmqA:
20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NNW_D_GCSD302_1
(25 KDA PROTEIN
ELICITOR)		 3fmq METHIONINE
AMINOPEPTIDASE 2
(Encephalitozoon
cuniculi) 		4 / 7 GLY A 209
HIS A 210
ASP A 141
HIS A 109
 None
FE  A 451 (-3.4A)
FE  A 452 ( 2.2A)
FUG  A 481 (-2.7A)
 0.74A 5nnwD-3fmqA:
undetectable		 5nnwD-3fmqA:
13.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NO9_D_95ZD302_1
(25 KDA PROTEIN
ELICITOR)		 3fmq METHIONINE
AMINOPEPTIDASE 2
(Encephalitozoon
cuniculi) 		4 / 7 GLY A 209
HIS A 210
ASP A 141
HIS A 109
 None
FE  A 451 (-3.4A)
FE  A 452 ( 2.2A)
FUG  A 481 (-2.7A)
 0.76A 5no9D-3fmqA:
undetectable		 5no9D-3fmqA:
13.54