SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'FUD'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AZM_A_AZMA262_1
(CARBONIC ANHYDRASE I)		 3vnk XYLOSE ISOMERASE
DOMAIN PROTEIN TIM
BARREL
([Clostridium]
cellulolyticum) 		4 / 8 PHE A 246
HIS A 209
HIS A 207
THR A  63
 FUD  A 301 (-4.7A)
MN  A 302 ( 3.2A)
None
None
 1.03A 1azmA-3vnkA:
undetectable		 1azmA-3vnkA:
23.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DMA_B_NCAB700_0
(EXOTOXIN A)		 3vnk XYLOSE ISOMERASE
DOMAIN PROTEIN TIM
BARREL
([Clostridium]
cellulolyticum) 		4 / 6 HIS A  66
GLY A  67
ALA A  36
GLU A  15
 None
FUD  A 301 ( 4.2A)
None
None
 1.03A 1dmaB-3vnkA:
undetectable		 1dmaB-3vnkA:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LWE_A_NVPA999_1
(HIV-1 REVERSE
TRANSCRIPTASE)		 3vnk XYLOSE ISOMERASE
DOMAIN PROTEIN TIM
BARREL
([Clostridium]
cellulolyticum) 		4 / 7 VAL A 242
TYR A   7
TYR A   6
GLY A   4
 None
None
FUD  A 301 (-4.6A)
None
 1.01A 1lweA-3vnkA:
undetectable		 1lweA-3vnkA:
18.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HA2_B_SCKB951_1
(ACETYLCHOLINESTERASE)		 3vnk XYLOSE ISOMERASE
DOMAIN PROTEIN TIM
BARREL
([Clostridium]
cellulolyticum) 		4 / 8 TYR A 158
TRP A 112
TYR A 109
HIS A  66
 None
FUD  A 301 (-4.1A)
None
None
 1.48A 2ha2B-3vnkA:
undetectable		 2ha2B-3vnkA:
18.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BLV_B_SAMB1281_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE J)		 3vnk XYLOSE ISOMERASE
DOMAIN PROTEIN TIM
BARREL
([Clostridium]
cellulolyticum) 		5 / 12 GLY A 206
GLY A 239
SER A 240
LEU A 149
GLY A 106
 None
None
None
None
FUD  A 301 ( 4.0A)
 0.78A 4blvB-3vnkA:
undetectable		 4blvB-3vnkA:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JUO_F_LFXF101_1
(DNA TOPOISOMERASE 4
SUBUNIT A
DNA TOPOISOMERASE 4
SUBUNIT B
E-SITE DNA)		 3vnk XYLOSE ISOMERASE
DOMAIN PROTEIN TIM
BARREL
([Clostridium]
cellulolyticum) 		3 / 4 SER A 240
GLY A 106
GLU A 156
 None
FUD  A 301 ( 4.0A)
FUD  A 301 (-2.9A)
 0.61A 4juoA-3vnkA:
undetectable
4juoC-3vnkA:
undetectable		 4juoA-3vnkA:
20.97
4juoC-3vnkA:
18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QB9_D_PARD500_1
(ENHANCED
INTRACELLULAR
SURVIVAL PROTEIN)		 3vnk XYLOSE ISOMERASE
DOMAIN PROTEIN TIM
BARREL
([Clostridium]
cellulolyticum) 		4 / 8 PHE A  30
THR A 210
GLU A 150
ASP A 183
 None
None
FUD  A 301 ( 2.4A)
MN  A 302 ( 3.2A)
 1.41A 4qb9D-3vnkA:
undetectable		 4qb9D-3vnkA:
18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5PAH_A_LDPA600_1
(PHENYLALANINE
4-MONOOXYGENASE)		 3vnk XYLOSE ISOMERASE
DOMAIN PROTEIN TIM
BARREL
([Clostridium]
cellulolyticum) 		4 / 4 HIS A 207
HIS A 209
TYR A   6
GLU A  34
 None
MN  A 302 ( 3.2A)
FUD  A 301 (-4.6A)
None
 1.19A 5pahA-3vnkA:
undetectable		 5pahA-3vnkA:
22.49