SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'FUC'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1BDW_B_DVAB8_0
(GRAMICIDIN A)		 5uk5 NEUROGENIC LOCUS
NOTCH HOMOLOG
PROTEIN 1
(Rattus
norvegicus) 		3 / 3 VAL A 324
VAL A 322
TRP A 327
 FUC  A 604 ( 4.9A)
FUC  A 604 (-4.4A)
None
 0.70A 1bdwA-5uk5A:
undetectable
1bdwB-5uk5A:
undetectable		 1bdwA-5uk5A:
3.47
1bdwB-5uk5A:
3.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWK_A_117A2_1
(HMG-COA REDUCTASE)		 3lei PLATELET AGGREGATION
FACTOR SM-HPAF
(Streptococcus
mitis) 		4 / 8 ARG A 112
SER A 174
ASN A 116
ASP A 114
 FUC  A1186 (-3.0A)
None
None
None
 1.26A 1hwkA-3leiA:
undetectable		 1hwkA-3leiA:
15.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I9G_A_SAMA301_1
(HYPOTHETICAL PROTEIN
RV2118C)		 2wmh FUCOLECTIN-RELATED
PROTEIN
(Streptococcus
pneumoniae) 		3 / 3 GLU A  85
HIS A  87
ASP A 251
 None
FUC  A1591 (-4.0A)
None
 0.82A 1i9gA-2wmhA:
undetectable		 1i9gA-2wmhA:
16.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LIN_A_TFPA154_1
(CALMODULIN)		 1fuj PR3
(Homo
sapiens) 		4 / 7 LEU A 137
MET A 139
GLU A 157
LEU A 155
 FUC  A 245 (-4.0A)
None
None
None
 1.12A 1linA-1fujA:
undetectable		 1linA-1fujA:
18.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N49_D_RITD401_1
(PROTEASE)		 1fuj PR3
(Homo
sapiens) 		6 / 11 GLY A  44
VAL A 121
ILE A 200
GLY A 211
PRO A 124
ILE A  47
 None
None
FUC  A 245 (-4.3A)
None
None
None
 1.37A 1n49C-1fujA:
undetectable		 1n49C-1fujA:
19.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NBI_C_SAMC2293_0
(GLYCINE
N-METHYLTRANSFERASE)		 4jy4 PGT121 LIGHT CHAIN
PGT121 HEAVY CHAIN
(Homo
sapiens;
Homo
sapiens) 		5 / 12 GLY B 104
THR B 105
ALA B  93
GLY A  41
HIS A  38
 None
None
None
FUC  B 310 ( 4.5A)
None
 1.31A 1nbiC-4jy4B:
undetectable		 1nbiC-4jy4B:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NBI_D_SAMD3293_0
(GLYCINE
N-METHYLTRANSFERASE)		 4jy4 PGT121 LIGHT CHAIN
PGT121 HEAVY CHAIN
(Homo
sapiens;
Homo
sapiens) 		5 / 12 GLY B 104
THR B 105
ALA B  93
GLY A  41
HIS A  38
 None
None
None
FUC  B 310 ( 4.5A)
None
 1.30A 1nbiD-4jy4B:
undetectable		 1nbiD-4jy4B:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TCO_C_FK5C509_2
(FK506-BINDING
PROTEIN)		 1gpz COMPLEMENT C1R
COMPONENT
(Homo
sapiens) 		5 / 11 TYR A 568
PHE A 567
VAL A 643
ILE A 656
PHE A 621
 None
FUC  A2003 (-3.4A)
None
None
None
 1.27A 1tcoC-1gpzA:
undetectable		 1tcoC-1gpzA:
14.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UPF_A_URFA999_1
(URACIL
PHOSPHORIBOSYLTRANSF
ERASE)		 4d72 GLYCOSIDE HYDROLASE
(Streptococcus
pneumoniae) 		4 / 5 MET A 527
ALA A 524
ILE A 562
ASP A 566
 None
FUC  A2007 ( 4.0A)
None
None
 1.06A 1upfA-4d72A:
undetectable		 1upfA-4d72A:
16.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UPF_C_URFC999_1
(URACIL
PHOSPHORIBOSYLTRANSF
ERASE)		 4d72 GLYCOSIDE HYDROLASE
(Streptococcus
pneumoniae) 		4 / 5 MET A 527
ALA A 524
ILE A 562
ASP A 566
 None
FUC  A2007 ( 4.0A)
None
None
 1.09A 1upfC-4d72A:
undetectable		 1upfC-4d72A:
16.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DPM_A_SAMA300_0
(PROTEIN
(ADENINE-SPECIFIC
METHYLTRANSFERASE
DPNII 1))		 1qot CHITIN BINDING
LECTIN, UEA-II
(Ulex
europaeus) 		5 / 12 GLY A 106
PHE A 127
GLY A 216
GLY A 217
PHE A  90
 FUC  A 501 (-3.7A)
None
None
None
None
 1.16A 2dpmA-1qotA:
undetectable		 2dpmA-1qotA:
22.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OMB_D_IPHD2002_0
(BENCE JONES KWR
PROTEIN -
IMMUNOGLOBULIN LIGHT
CHAIN)		 1lq2 BETA-D-GLUCAN
GLUCOHYDROLASE
ISOENZYME EXO1
(Hordeum
vulgare) 		4 / 7 TYR A 489
PRO A 488
PRO A 502
TYR A 425
 None
None
FUC  A 614 ( 3.8A)
NAG  A 616 (-4.8A)
 1.20A 2ombC-1lq2A:
undetectable
2ombD-1lq2A:
undetectable		 2ombC-1lq2A:
16.61
2ombD-1lq2A:
16.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OXT_A_SAMA300_1
(NUCLEOSIDE-2'-O-METH
YLTRANSFERASE)		 5bo6 SIA-ALPHA-2,3-GAL-BE
TA-1,4-GLCNAC-R:ALPH
A
2,8-SIALYLTRANSFERAS
E
(Homo
sapiens) 		3 / 3 SER A 174
HIS A 317
ASP A 184
 None
FUC  A 408 (-4.7A)
None
 0.82A 2oxtA-5bo6A:
undetectable		 2oxtA-5bo6A:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q9R_A_BEZA203_0
(PROTEIN OF UNKNOWN
FUNCTION)		 4gdj NEURAMINIDASE
(Influenza
A
virus) 		4 / 5 LEU A 303
GLY A 291
PRO A 301
ILE A 273
 None
None
None
FUC  A 503 ( 4.2A)
 0.84A 2q9rA-4gdjA:
undetectable		 2q9rA-4gdjA:
17.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VQY_A_PARA1201_2
(AAC(6')-IB)		 4wrl MACROPHAGE
COLONY-STIMULATING
FACTOR 1 RECEPTOR
(Homo
sapiens) 		3 / 3 TRP A  58
GLN A  77
TRP A 159
 None
FUC  A 402 (-4.0A)
None
 1.08A 2vqyA-4wrlA:
undetectable		 2vqyA-4wrlA:
19.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BWM_A_SAMA301_0
(CATECHOL
O-METHYLTRANSFERASE)		 5i8o HMM5 ANTIBODY HEAVY
CHAIN
HMM5 ANTIBODY LIGHT
CHAIN
(Homo
sapiens;
Homo
sapiens) 		5 / 12 VAL L 100
GLY H  48
TYR L  94
ILE H  33
ASN H  32
 None
None
None
None
FUC  H 301 (-3.2A)
 1.38A 3bwmA-5i8oL:
undetectable		 3bwmA-5i8oL:
25.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BWM_A_SAMA301_0
(CATECHOL
O-METHYLTRANSFERASE)		 5i8o HMM5 ANTIBODY HEAVY
CHAIN
HMM5 ANTIBODY LIGHT
CHAIN
(Homo
sapiens;
Homo
sapiens) 		5 / 12 VAL L 100
GLY H  48
TYR L  94
ILE H  50
ASN H  32
 None
None
None
None
FUC  H 301 (-3.2A)
 1.37A 3bwmA-5i8oL:
undetectable		 3bwmA-5i8oL:
25.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EL0_A_1UNA201_2
(PROTEASE)		 1fuj PR3
(Homo
sapiens) 		5 / 9 VAL A 121
ILE A 200
GLY A 211
PRO A 124
ILE A  47
 None
FUC  A 245 (-4.3A)
None
None
None
 0.93A 3el0B-1fujA:
undetectable		 3el0B-1fujA:
19.31
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3GAL_A_1GNA998_1
(GALECTIN-7)		 3vv1 PROTEIN LEC-6
(Caenorhabditis
elegans) 		6 / 6 HIS A  60
ASN A  62
ARG A  64
ASN A  73
TRP A  80
GLU A  83
 GAL  A 201 (-3.8A)
GAL  A 201 (-3.9A)
FUC  A 202 (-2.7A)
GAL  A 201 (-3.8A)
GAL  A 201 ( 3.8A)
FUC  A 202 (-2.7A)
 0.17A 3galA-3vv1A:
21.1		 3galA-3vv1A:
30.91
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3GAL_B_1GNB999_1
(GALECTIN-7)		 3vv1 PROTEIN LEC-6
(Caenorhabditis
elegans) 		6 / 6 HIS A  60
ASN A  62
ARG A  64
ASN A  73
TRP A  80
GLU A  83
 GAL  A 201 (-3.8A)
GAL  A 201 (-3.9A)
FUC  A 202 (-2.7A)
GAL  A 201 (-3.8A)
GAL  A 201 ( 3.8A)
FUC  A 202 (-2.7A)
 0.30A 3galB-3vv1A:
21.0		 3galB-3vv1A:
30.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GWU_A_SREA801_1
(TRANSPORTER)		 4d72 GLYCOSIDE HYDROLASE
(Streptococcus
pneumoniae) 		5 / 12 LEU A 478
LEU A 439
LEU A 483
ASP A 482
THR A 523
 None
None
None
None
FUC  A2007 (-2.8A)
 1.35A 3gwuA-4d72A:
undetectable		 3gwuA-4d72A:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HS4_A_AZMA702_1
(CARBONIC ANHYDRASE 2)		 2h6o MAJOR OUTER ENVELOPE
GLYCOPROTEIN GP350
(Human
gammaherpesvirus
4) 		4 / 7 VAL A 393
TYR A 324
TRP A 352
LYS A 401
 None
None
None
FUC  A1364 ( 4.3A)
 1.20A 3hs4A-2h6oA:
undetectable		 3hs4A-2h6oA:
17.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KPB_D_SAMD1000_0
(UNCHARACTERIZED
PROTEIN MJ0100)		 3e0g LEUKEMIA INHIBITORY
FACTOR RECEPTOR
(Homo
sapiens) 		5 / 10 THR A 261
VAL A 209
ILE A 210
ILE A 253
SER A 254
 None
None
None
None
FUC  A 492 ( 3.8A)
 1.27A 3kpbD-3e0gA:
undetectable		 3kpbD-3e0gA:
13.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KVR_B_URFB2011_1
(URIDINE
PHOSPHORYLASE)		 4fom POLIOVIRUS
RECEPTOR-RELATED
PROTEIN 3
(Homo
sapiens) 		5 / 10 THR A 188
GLU A 187
LEU A 181
LEU A 263
ILE A 265
 FUC  A 411 ( 4.9A)
None
None
None
None
 1.35A 3kvrB-4fomA:
undetectable		 3kvrB-4fomA:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NBQ_A_URFA400_1
(URIDINE
PHOSPHORYLASE 1)		 4fom POLIOVIRUS
RECEPTOR-RELATED
PROTEIN 3
(Homo
sapiens) 		5 / 9 THR A 188
GLU A 187
LEU A 181
LEU A 263
ILE A 265
 FUC  A 411 ( 4.9A)
None
None
None
None
 1.33A 3nbqA-4fomA:
undetectable		 3nbqA-4fomA:
19.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3O5R_A_FK5A1001_1
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP5)		 1gpz COMPLEMENT C1R
COMPONENT
(Homo
sapiens) 		5 / 11 TYR A 568
PHE A 567
VAL A 643
ILE A 656
PHE A 621
 None
FUC  A2003 (-3.4A)
None
None
None
 1.12A 3o5rA-1gpzA:
undetectable		 3o5rA-1gpzA:
16.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R24_A_SAMA302_0
(2'-O-METHYL
TRANSFERASE)		 1led WEST-CENTRAL AFRICAN
LEGUME LECTIN IV
(Griffonia
simplicifolia) 		5 / 12 GLY A 110
SER A 101
GLY A  26
ASP A 149
PHE A 108
 None
NAG  A 256 (-2.7A)
FUC  A 262 (-3.4A)
None
FUC  A 252 ( 4.6A)
 1.30A 3r24A-1ledA:
undetectable		 3r24A-1ledA:
20.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V4T_A_ACTA505_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)		 3mj9 JUNCTIONAL ADHESION
MOLECULE-LIKE
(Mus
musculus) 		3 / 3 THR A  30
ASN A  80
GLU A  32
 FUC  A 506 (-3.1A)
FUC  A 506 (-3.9A)
None
 0.81A 3v4tA-3mj9A:
undetectable
3v4tC-3mj9A:
undetectable		 3v4tA-3mj9A:
19.81
3v4tC-3mj9A:
19.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_A_ZPCA1318_2
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 5udy ECTONUCLEOTIDE
PYROPHOSPHATASE/PHOS
PHODIESTERASE FAMILY
MEMBER 7
(Homo
sapiens) 		4 / 7 TYR A 194
VAL A  36
ILE A 243
GLU A 171
 None
None
None
FUC  A 508 ( 4.3A)
 0.99A 4a97E-5udyA:
undetectable		 4a97E-5udyA:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_D_ZPCD1318_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 5udy ECTONUCLEOTIDE
PYROPHOSPHATASE/PHOS
PHODIESTERASE FAMILY
MEMBER 7
(Homo
sapiens) 		4 / 8 TYR A 194
VAL A  36
ILE A 243
GLU A 171
 None
None
None
FUC  A 508 ( 4.3A)
 0.93A 4a97C-5udyA:
undetectable		 4a97C-5udyA:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_H_ZPCH1318_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 5udy ECTONUCLEOTIDE
PYROPHOSPHATASE/PHOS
PHODIESTERASE FAMILY
MEMBER 7
(Homo
sapiens) 		4 / 8 TYR A 194
VAL A  36
ILE A 243
GLU A 171
 None
None
None
FUC  A 508 ( 4.3A)
 1.00A 4a97G-5udyA:
undetectable		 4a97G-5udyA:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FO4_A_MOAA502_1
(INOSINE
5'-MONOPHOSPHATE
DEHYDROGENASE)		 5dzv PROTEIN PCDHA7
(Mus
musculus) 		4 / 8 SER A 238
ASN A 236
CYH A 305
GLY A 303
 FUC  A 616 ( 4.2A)
NAG  A 615 (-1.9A)
None
None
 1.00A 4fo4A-5dzvA:
undetectable		 4fo4A-5dzvA:
22.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HTF_A_ACTA303_0
(S-ADENOSYLMETHIONINE
-DEPENDENT
METHYLTRANSFERASE)		 1k12 LECTIN
(Anguilla
anguilla) 		3 / 3 TYR A  46
HIS A  52
ARG A  79
 None
FUC  A 159 (-3.8A)
FUC  A 159 (-2.7A)
 1.10A 4htfA-1k12A:
undetectable		 4htfA-1k12A:
18.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MDA_A_RLTA403_1
(MARINER MOS1
TRANSPOSASE)		 3j0a TOLL-LIKE RECEPTOR 5
(Homo
sapiens) 		4 / 6 ASP A 390
ASP A 366
ALA A 320
TYR A 321
 None
None
FUC  A1343 (-3.3A)
None
 1.06A 4mdaA-3j0aA:
undetectable		 4mdaA-3j0aA:
12.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MDB_A_RLTA401_1
(MARINER MOS1
TRANSPOSASE)		 3j0a TOLL-LIKE RECEPTOR 5
(Homo
sapiens) 		4 / 6 ASP A 390
ASP A 366
ALA A 320
TYR A 321
 None
None
FUC  A1343 (-3.3A)
None
 1.06A 4mdbA-3j0aA:
undetectable		 4mdbA-3j0aA:
12.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MV7_A_PPFA501_1
(BIOTIN CARBOXYLASE)		 3vv1 PROTEIN LEC-6
(Caenorhabditis
elegans) 		4 / 7 ARG A  46
VAL A  71
GLU A  83
ARG A  85
 FUC  A 202 ( 4.7A)
None
FUC  A 202 (-2.7A)
FUC  A 202 ( 4.1A)
 1.26A 4mv7A-3vv1A:
undetectable		 4mv7A-3vv1A:
15.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RTM_A_SAMA301_0
(DNA ADENINE
METHYLASE)		 1led WEST-CENTRAL AFRICAN
LEGUME LECTIN IV
(Griffonia
simplicifolia) 		5 / 12 GLY A 107
GLY A 106
GLY A  90
ILE A 146
TYR A 143
 GAL  A 253 ( 3.4A)
FUC  A 254 ( 3.8A)
None
None
None
 0.96A 4rtmA-1ledA:
undetectable		 4rtmA-1ledA:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XUE_B_SAMB303_0
(CATECHOL
O-METHYLTRANSFERASE)		 5i8o HMM5 ANTIBODY HEAVY
CHAIN
HMM5 ANTIBODY LIGHT
CHAIN
(Homo
sapiens;
Homo
sapiens) 		5 / 12 VAL L 100
GLY H  48
TYR L  94
ILE H  33
ASN H  32
 None
None
None
None
FUC  H 301 (-3.2A)
 1.42A 4xueB-5i8oL:
undetectable		 4xueB-5i8oL:
25.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XUE_B_SAMB303_0
(CATECHOL
O-METHYLTRANSFERASE)		 5i8o HMM5 ANTIBODY HEAVY
CHAIN
HMM5 ANTIBODY LIGHT
CHAIN
(Homo
sapiens;
Homo
sapiens) 		5 / 12 VAL L 100
GLY H  48
TYR L  94
ILE H  50
ASN H  32
 None
None
None
None
FUC  H 301 (-3.2A)
 1.37A 4xueB-5i8oL:
undetectable		 4xueB-5i8oL:
25.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YSH_B_GLYB401_0
(GLYCINE OXIDASE)		 5yow GLYCOPROTEIN
POLYPROTEIN
(Heartland
virus) 		4 / 6 PHE A 328
LYS A  59
TYR A 202
ALA A 170
 None
FUC  A 504 (-2.9A)
None
None
 1.31A 4yshB-5yowA:
undetectable		 4yshB-5yowA:
20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A06_B_SORB1341_0
(ALDOSE-ALDOSE
OXIDOREDUCTASE)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		4 / 7 ARG A  28
ARG A 230
ASP A 234
ILE A 184
 FUC  A 505 ( 4.3A)
None
None
None
 1.13A 5a06B-5m8tA:
undetectable		 5a06B-5m8tA:
19.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B8I_C_FK5C201_1
(SERINE/THREONINE-PRO
TEIN PHOSPHATASE
PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE)		 4hq1 PROBABLE RECEPTOR
PROTEIN KINASE TMK1
(Arabidopsis
thaliana) 		4 / 6 LEU A 214
PRO A 182
PHE A 185
GLU A 184
 None
None
None
FUC  A 505 (-3.5A)
 1.23A 5b8iA-4hq1A:
undetectable		 5b8iA-4hq1A:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JH7_D_6K9D502_0
(TUBULIN BETA-2B
CHAIN)		 2eae ALPHA-FUCOSIDASE
(Bifidobacterium
bifidum) 		5 / 11 GLN A 764
ASN A 395
VAL A 402
SER A 401
TYR A  38
 FUC  A 899 (-4.3A)
None
None
None
None
 1.37A 5jh7D-2eaeA:
undetectable		 5jh7D-2eaeA:
19.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LRB_A_ACRA1003_1
(ALPHA-1,4 GLUCAN
PHOSPHORYLASE)		 2wmh FUCOLECTIN-RELATED
PROTEIN
(Streptococcus
pneumoniae) 		4 / 6 GLU A 516
THR A 252
TYR A 275
TYR A  53
 None
None
None
FUC  A1591 (-4.6A)
 1.44A 5lrbA-2wmhA:
undetectable		 5lrbA-2wmhA:
20.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M54_E_TA1E502_1
(TUBULIN BETA-2B
CHAIN)		 1zhn CD1D1 ANTIGEN
(Mus
musculus) 		5 / 12 SER A 114
GLN A  55
ARG A 173
GLY A 174
LEU A 175
 FUC  A 287 (-4.4A)
None
None
None
None
 1.09A 5m54E-1zhnA:
undetectable		 5m54E-1zhnA:
19.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0X_B_SAMB501_1
(PEPTIDE
N-METHYLTRANSFERASE)		 4d72 GLYCOSIDE HYDROLASE
(Streptococcus
pneumoniae) 		3 / 3 SER A 559
ALA A 524
THR A 531
 None
FUC  A2007 ( 4.0A)
None
 0.65A 5n0xB-4d72A:
undetectable		 5n0xB-4d72A:
19.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NKN_A_LOCA201_1
(NEUTROPHIL
GELATINASE-ASSOCIATE
D LIPOCALIN)		 5a8z NEUTROPHIL ELASTASE
(Homo
sapiens) 		5 / 12 GLY A 207
LEU A 155
TRP A  27
PHE A  29
THR A  45
 FUC  A 402 (-3.7A)
None
None
None
None
 1.44A 5nknA-5a8zA:
undetectable		 5nknA-5a8zA:
18.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NNA_A_BZMA301_0
(ISATIN HYDROLASE A)		 1qot CHITIN BINDING
LECTIN, UEA-II
(Ulex
europaeus) 		5 / 12 ILE A 152
HIS A 144
SER A 103
GLY A 106
GLY A 109
 None
MN  A 301 (-3.3A)
None
FUC  A 501 (-3.7A)
None
 1.15A 5nnaA-1qotA:
undetectable		 5nnaA-1qotA:
22.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NNA_B_BZMB301_0
(ISATIN HYDROLASE A)		 1qot CHITIN BINDING
LECTIN, UEA-II
(Ulex
europaeus) 		5 / 12 ILE A 152
HIS A 144
SER A 103
GLY A 106
GLY A 109
 None
MN  A 301 (-3.3A)
None
FUC  A 501 (-3.7A)
None
 1.15A 5nnaB-1qotA:
undetectable		 5nnaB-1qotA:
22.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NNA_C_BZMC301_0
(ISATIN HYDROLASE A)		 1qot CHITIN BINDING
LECTIN, UEA-II
(Ulex
europaeus) 		5 / 12 ILE A 152
HIS A 144
SER A 103
GLY A 106
GLY A 109
 None
MN  A 301 (-3.3A)
None
FUC  A 501 (-3.7A)
None
 1.15A 5nnaC-1qotA:
undetectable		 5nnaC-1qotA:
22.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NNA_D_BZMD301_0
(ISATIN HYDROLASE A)		 1qot CHITIN BINDING
LECTIN, UEA-II
(Ulex
europaeus) 		5 / 12 ILE A 152
HIS A 144
SER A 103
GLY A 106
GLY A 109
 None
MN  A 301 (-3.3A)
None
FUC  A 501 (-3.7A)
None
 1.17A 5nnaD-1qotA:
undetectable		 5nnaD-1qotA:
22.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AWP_A_FVXA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		 5f9a ADHESIN BINDING
FUCOSYLATED
HISTO-BLOOD GROUP
ANTIGEN,ADHESIN,ADHE
SIN BINDING
FUCOSYLATED
HISTO-BLOOD GROUP
ANTIGEN
(Helicobacter
pylori) 		5 / 9 SER A 149
SER A 115
SER A 117
GLY A 193
THR A 188
 None
None
None
FUC  A1005 ( 4.9A)
None
 1.35A 6awpA-5f9aA:
0.1		 6awpA-5f9aA:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B8K_A_W9TA300_0
(GALECTIN-3)		 3vv1 PROTEIN LEC-6
(Caenorhabditis
elegans) 		7 / 7 HIS A  60
ASN A  62
ARG A  64
ASN A  73
TRP A  80
GLU A  83
ARG A  85
 GAL  A 201 (-3.8A)
GAL  A 201 (-3.9A)
FUC  A 202 (-2.7A)
GAL  A 201 (-3.8A)
GAL  A 201 ( 3.8A)
FUC  A 202 (-2.7A)
FUC  A 202 ( 4.1A)
 0.32A 6b8kA-3vv1A:
21.6		 6b8kA-3vv1A:
19.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6B94_A_W9TA201_0
(GALECTIN-1)		 3vv1 PROTEIN LEC-6
(Caenorhabditis
elegans) 		7 / 8 HIS A  60
ASN A  62
ARG A  64
ASN A  73
TRP A  80
GLU A  83
ARG A  85
 GAL  A 201 (-3.8A)
GAL  A 201 (-3.9A)
FUC  A 202 (-2.7A)
GAL  A 201 (-3.8A)
GAL  A 201 ( 3.8A)
FUC  A 202 (-2.7A)
FUC  A 202 ( 4.1A)
 0.49A 6b94A-3vv1A:
18.2		 6b94A-3vv1A:
31.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6B94_B_W9TB201_0
(GALECTIN-1)		 3vv1 PROTEIN LEC-6
(Caenorhabditis
elegans) 		7 / 10 HIS A  60
ASN A  62
ARG A  64
ASN A  73
TRP A  80
GLU A  83
ARG A  85
 GAL  A 201 (-3.8A)
GAL  A 201 (-3.9A)
FUC  A 202 (-2.7A)
GAL  A 201 (-3.8A)
GAL  A 201 ( 3.8A)
FUC  A 202 (-2.7A)
FUC  A 202 ( 4.1A)
 0.41A 6b94A-3vv1A:
18.2
6b94B-3vv1A:
18.1		 6b94A-3vv1A:
31.00
6b94B-3vv1A:
31.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DJZ_A_GMJA301_1
(SIGMA NON-OPIOID
INTRACELLULAR
RECEPTOR 1)		 4d72 GLYCOSIDE HYDROLASE
(Streptococcus
pneumoniae) 		4 / 6 ASP A 657
GLN A 590
GLU A 710
THR A 520
 None
None
FUC  A2007 ( 2.9A)
None
 0.96A 6djzA-4d72A:
undetectable		 6djzA-4d72A:
15.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DK1_C_GM4C301_0
(SIGMA NON-OPIOID
INTRACELLULAR
RECEPTOR 1)		 4d72 GLYCOSIDE HYDROLASE
(Streptococcus
pneumoniae) 		5 / 11 ALA A 524
TYR A 440
ASP A 657
GLU A 710
THR A 520
 FUC  A2007 ( 4.0A)
FUC  A2007 (-4.4A)
None
FUC  A2007 ( 2.9A)
None
 1.22A 6dk1C-4d72A:
undetectable		 6dk1C-4d72A:
15.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FK2_A_SORA302_0
(GALECTIN-3)		 3vv1 PROTEIN LEC-6
(Caenorhabditis
elegans) 		4 / 4 ARG A  64
GLU A  67
GLU A  83
ARG A  85
 FUC  A 202 (-2.7A)
FUC  A 202 (-2.9A)
FUC  A 202 (-2.7A)
FUC  A 202 ( 4.1A)
 0.55A 6fk2A-3vv1A:
21.7		 6fk2A-3vv1A:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FK2_A_SORA302_0
(GALECTIN-3)		 3vv1 PROTEIN LEC-6
(Caenorhabditis
elegans) 		4 / 4 ARG A  85
GLU A  83
GLU A  67
ARG A  64
 FUC  A 202 ( 4.1A)
FUC  A 202 (-2.7A)
FUC  A 202 (-2.9A)
FUC  A 202 (-2.7A)
 1.00A 6fk2A-3vv1A:
21.7		 6fk2A-3vv1A:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNF_A_QPSA602_1
(-)		 1led WEST-CENTRAL AFRICAN
LEGUME LECTIN IV
(Griffonia
simplicifolia) 		5 / 12 ASP A  89
ASN A  82
ARG A  48
PRO A  86
GLY A  84
 GAL  A 253 ( 2.8A)
None
FUC  A 254 ( 4.2A)
None
None
 1.20A 6gnfA-1ledA:
undetectable		 6gnfA-1ledA:
19.13