SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'FTT'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MEI_A_MOAA600_1
(INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE)		 5w7a ACYLOXYACYL
HYDROLASE LARGE
SUBUNIT
(Oryctolagus
cuniculus) 		4 / 8 ASP B 296
ASN B 335
ILE B 336
GLY B 340
 None
None
None
FTT  B 609 ( 3.3A)
 0.88A 1meiA-5w7aB:
undetectable		 1meiA-5w7aB:
11.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MEI_A_MOAA600_1
(INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE)		 5w7c ACYLOXYACYL
HYDROLASE
(Homo
sapiens) 		4 / 8 ASP C 297
ASN C 336
ILE C 337
GLY C 341
 None
None
None
FTT  C 610 ( 3.1A)
 0.87A 1meiA-5w7cC:
undetectable		 1meiA-5w7cC:
10.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QD3_A_CHDA501_0
(FERROCHELATASE)		 5w7c ACYLOXYACYL
HYDROLASE
ACYLOXYACYL
HYDROLASE
(Homo
sapiens;
Homo
sapiens) 		5 / 11 LEU C 288
LEU A  73
ILE C 270
THR A  82
VAL A  50
 None
None
FTT  C 611 (-3.9A)
None
FTT  C 611 ( 4.3A)
 1.22A 2qd3A-5w7cC:
2.5		 2qd3A-5w7cC:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G2O_B_SAMB600_0
(PCZA361.24)		 5w7a ACYLOXYACYL
HYDROLASE LARGE
SUBUNIT
(Oryctolagus
cuniculus) 		5 / 12 GLY B 452
LEU B 447
ASP B 527
SER B 464
GLY B 461
 None
FTT  B 609 (-4.3A)
FTT  B 609 ( 4.8A)
None
None
 0.83A 3g2oB-5w7aB:
2.2		 3g2oB-5w7aB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SG9_B_KANB305_1
(APH(2'')-ID)		 5w7a ACYLOXYACYL
HYDROLASE LARGE
SUBUNIT
(Oryctolagus
cuniculus) 		4 / 8 HIS B 530
ASP B 296
GLU B 272
TRP B 273
 FTT  B 609 (-3.8A)
None
None
None
 0.89A 3sg9B-5w7aB:
undetectable		 3sg9B-5w7aB:
15.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SG9_B_KANB305_1
(APH(2'')-ID)		 5w7c ACYLOXYACYL
HYDROLASE
(Homo
sapiens) 		4 / 8 HIS C 530
ASP C 297
GLU C 273
TRP C 274
 DAO  C 609 ( 3.3A)
None
None
FTT  C 611 (-4.9A)
 0.93A 3sg9B-5w7cC:
undetectable		 3sg9B-5w7cC:
10.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F4D_A_CHDA504_0
(FERROCHELATASE,
MITOCHONDRIAL)		 5w7c ACYLOXYACYL
HYDROLASE
ACYLOXYACYL
HYDROLASE
(Homo
sapiens;
Homo
sapiens) 		5 / 12 LEU C 288
LEU A  73
ILE C 270
THR A  82
VAL A  50
 None
None
FTT  C 611 (-3.9A)
None
FTT  C 611 ( 4.3A)
 1.21A 4f4dA-5w7cC:
3.0		 4f4dA-5w7cC:
undetectable
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5W7B_A_PA1A206_1
(ACYLOXYACYL
HYDROLASE SMALL
SUBUNIT
ACYLOXYACYL
HYDROLASE LARGE
SUBUNIT)		 5w7a ACYLOXYACYL
HYDROLASE LARGE
SUBUNIT
ACYLOXYACYL
HYDROLASE SMALL
SUBUNIT
(Oryctolagus
cuniculus) 		4 / 4 TYR A  38
GLY B 340
ASN B 372
ARG B 378
 None
FTT  B 609 ( 3.3A)
FTT  B 609 (-3.1A)
PO4  B 607 (-3.3A)
 0.33A 5w7bA-5w7aA:
12.0
5w7bC-5w7aA:
undetectable		 5w7bA-5w7aA:
100.00
5w7bC-5w7aA:
14.29
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5W7B_B_PA1B204_1
(ACYLOXYACYL
HYDROLASE SMALL
SUBUNIT
ACYLOXYACYL
HYDROLASE LARGE
SUBUNIT)		 5w7a ACYLOXYACYL
HYDROLASE LARGE
SUBUNIT
(Oryctolagus
cuniculus) 		3 / 3 GLY B 340
ASN B 372
ARG B 378
 FTT  B 609 ( 3.3A)
FTT  B 609 (-3.1A)
PO4  B 607 (-3.3A)
 0.17A 5w7bD-5w7aB:
65.6		 5w7bD-5w7aB:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B0I_B_TA1B502_1
(TUBULIN BETA CHAIN)		 5w7c ACYLOXYACYL
HYDROLASE
(Homo
sapiens) 		5 / 12 VAL A  86
LEU C 288
LEU A  73
GLY A  43
LEU A  46
 None
None
None
FTT  A 202 ( 3.2A)
FTT  C 611 ( 4.5A)
 1.06A 6b0iB-5w7cA:
undetectable		 6b0iB-5w7cA:
20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B0I_B_TA1B502_1
(TUBULIN BETA CHAIN)		 5w7c ACYLOXYACYL
HYDROLASE
(Homo
sapiens) 		5 / 12 VAL A  86
LEU C 292
LEU A  79
GLY A  43
LEU A  46
 None
None
None
FTT  A 202 ( 3.2A)
FTT  C 611 ( 4.5A)
 0.92A 6b0iB-5w7cA:
undetectable		 6b0iB-5w7cA:
20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B0L_B_TA1B502_1
(TUBULIN BETA CHAIN)		 5w7c ACYLOXYACYL
HYDROLASE
(Homo
sapiens) 		5 / 12 VAL A  86
LEU C 288
LEU A  73
GLY A  43
LEU A  46
 None
None
None
FTT  A 202 ( 3.2A)
FTT  C 611 ( 4.5A)
 1.07A 6b0lB-5w7cA:
undetectable		 6b0lB-5w7cA:
20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B0L_B_TA1B502_1
(TUBULIN BETA CHAIN)		 5w7c ACYLOXYACYL
HYDROLASE
(Homo
sapiens) 		5 / 12 VAL A  86
LEU C 292
LEU A  79
GLY A  43
LEU A  46
 None
None
None
FTT  A 202 ( 3.2A)
FTT  C 611 ( 4.5A)
 0.82A 6b0lB-5w7cA:
undetectable		 6b0lB-5w7cA:
20.69