SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'FTG'


List of Similar Pattern of Amino Acids


Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID
Hit
Macromolecule
Res.
Matches
Interface HETATM RMSD Dali
Z-score
Seq.
Identity (%)
View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YVL_A_SAMA601_0
(HYPOTHETICAL PROTEIN)
6d2l HISTONE-ARGININE
METHYLTRANSFERASE
CARM1

(Homo
sapiens)
5 / 12 ILE A 197
GLY A 192
GLY A 194
SER A 195
ALA A 215
FTG  A 501 (-4.7A)
FTG  A 501 (-3.2A)
FTG  A 501 ( 3.9A)
None
FTG  A 501 (-3.4A)
1.11A 2yvlA-6d2lA:
10.7
2yvlA-6d2lA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EKT_B_017B200_2
(PROTEASE)
6d2l HISTONE-ARGININE
METHYLTRANSFERASE
CARM1

(Homo
sapiens)
5 / 9 ALA A 203
VAL A 188
ILE A 197
ALA A 212
ILE A 210
None
None
FTG  A 501 (-4.7A)
None
None
1.05A 3ektB-6d2lA:
undetectable
3ektB-6d2lA:
17.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G88_A_SAMA303_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE G)
6d2l HISTONE-ARGININE
METHYLTRANSFERASE
CARM1

(Homo
sapiens)
5 / 11 GLY A 192
GLY A 194
ALA A 215
GLU A 243
ARG A 168
FTG  A 501 (-3.2A)
FTG  A 501 ( 3.9A)
FTG  A 501 (-3.4A)
FTG  A 501 (-3.2A)
FTG  A 501 (-3.3A)
0.78A 3g88A-6d2lA:
9.1
3g88A-6d2lA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G88_B_SAMB303_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE G)
6d2l HISTONE-ARGININE
METHYLTRANSFERASE
CARM1

(Homo
sapiens)
5 / 11 GLY A 192
GLY A 194
ALA A 215
GLU A 243
ARG A 168
FTG  A 501 (-3.2A)
FTG  A 501 ( 3.9A)
FTG  A 501 (-3.4A)
FTG  A 501 (-3.2A)
FTG  A 501 (-3.3A)
0.80A 3g88B-6d2lA:
9.4
3g88B-6d2lA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G89_A_SAMA303_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE G)
6d2l HISTONE-ARGININE
METHYLTRANSFERASE
CARM1

(Homo
sapiens)
5 / 12 GLY A 192
GLY A 194
ALA A 215
GLU A 243
ARG A 168
FTG  A 501 (-3.2A)
FTG  A 501 ( 3.9A)
FTG  A 501 (-3.4A)
FTG  A 501 (-3.2A)
FTG  A 501 (-3.3A)
0.82A 3g89A-6d2lA:
9.8
3g89A-6d2lA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G89_B_SAMB303_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE G)
6d2l HISTONE-ARGININE
METHYLTRANSFERASE
CARM1

(Homo
sapiens)
5 / 11 GLY A 192
GLY A 194
ALA A 215
GLU A 243
ARG A 168
FTG  A 501 (-3.2A)
FTG  A 501 ( 3.9A)
FTG  A 501 (-3.4A)
FTG  A 501 (-3.2A)
FTG  A 501 (-3.3A)
0.83A 3g89B-6d2lA:
9.5
3g89B-6d2lA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G8B_A_SAMA303_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE G)
6d2l HISTONE-ARGININE
METHYLTRANSFERASE
CARM1

(Homo
sapiens)
5 / 12 GLY A 192
GLY A 194
ALA A 215
GLU A 243
ARG A 168
FTG  A 501 (-3.2A)
FTG  A 501 ( 3.9A)
FTG  A 501 (-3.4A)
FTG  A 501 (-3.2A)
FTG  A 501 (-3.3A)
0.83A 3g8bA-6d2lA:
9.6
3g8bA-6d2lA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G8B_B_SAMB303_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE G)
6d2l HISTONE-ARGININE
METHYLTRANSFERASE
CARM1

(Homo
sapiens)
5 / 12 GLY A 192
GLY A 194
ALA A 215
GLU A 243
ARG A 168
FTG  A 501 (-3.2A)
FTG  A 501 ( 3.9A)
FTG  A 501 (-3.4A)
FTG  A 501 (-3.2A)
FTG  A 501 (-3.3A)
0.84A 3g8bB-6d2lA:
9.2
3g8bB-6d2lA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VYW_C_SAMC401_1
(MNMC2)
6d2l HISTONE-ARGININE
METHYLTRANSFERASE
CARM1

(Homo
sapiens)
4 / 6 GLY A 194
GLU A 214
ASP A 190
GLU A 243
FTG  A 501 ( 3.9A)
FTG  A 501 (-2.5A)
None
FTG  A 501 (-3.2A)
0.78A 3vywC-6d2lA:
7.0
3vywC-6d2lA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BLV_A_SAMA1281_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE J)
6d2l HISTONE-ARGININE
METHYLTRANSFERASE
CARM1

(Homo
sapiens)
5 / 12 TYR A 355
GLY A 290
HIS A 293
ASP A 291
GLY A 260
None
None
SO4  A 502 ( 4.8A)
None
FTG  A 501 ( 4.3A)
1.14A 4blvA-6d2lA:
8.1
4blvA-6d2lA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5C0O_E_SAME301_0
(TRNA
(ADENINE(58)-N(1))-M
ETHYLTRANSFERASE
TRMI)
6d2l HISTONE-ARGININE
METHYLTRANSFERASE
CARM1

(Homo
sapiens)
5 / 12 GLY A 192
GLY A 194
LEU A 198
ALA A 215
GLU A 243
FTG  A 501 (-3.2A)
FTG  A 501 ( 3.9A)
None
FTG  A 501 (-3.4A)
FTG  A 501 (-3.2A)
0.84A 5c0oE-6d2lA:
10.4
5c0oE-6d2lA:
undetectable